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Targeting Glutamine Metabolism as an Attractive Therapeutic Strategy for Acute Myeloid Leukemia
Targeting Glutamine Metabolism as an Attractive Therapeutic Strategy for Acute Myeloid Leukemia
Relapse after chemotherapy and hematopoietic stem cell transplantation leads to adverse prognosis for acute myeloid leukem...
Utility of Measurable Residual Disease (MRD) Assessment in Mantle Cell Lymphoma
Utility of Measurable Residual Disease (MRD) Assessment in Mantle Cell Lymphoma
Mantle cell lymphoma (MCL) treatment advances have significantly improved disease-free remission, with greater focus in cl...
Immunotherapy in Early-Stage Triple-Negative Breast Cancer: Where Are We Now and Where Are We Headed?
Immunotherapy in Early-Stage Triple-Negative Breast Cancer: Where Are We Now and Where Are We Headed?
Recently, the addition of PD-1 pathway targeting immune checkpoint inhibitors (ICI) to standard neoadjuvant chemotherapy f...
Critical Appraisal of Proton Therapy for Patients with Central Nervous System (CNS) Malignancies
Critical Appraisal of Proton Therapy for Patients with Central Nervous System (CNS) Malignancies
As more hospital-based proton treatment centres become operational, the indications for proton beam therapy (PBT) are bein...
New Developments in Treating RAS-Mutated Metastatic Colorectal Cancer
New Developments in Treating RAS-Mutated Metastatic Colorectal Cancer
One of the great challenges in digestive oncology is choosing the optimal therapy for RAS-mutated metastatic colorectal ca...
The Intersection of Prostate Cancer and Hypertension: a Call to Action
The Intersection of Prostate Cancer and Hypertension: a Call to Action
With improvements in treatment and survival from prostate cancer, comorbid cardiac conditions will significantly impact ov...
Measurable Residual Disease in Chronic Lymphocytic Leukemia: Current Understanding and Evolving Role in Clinical Practice
Measurable Residual Disease in Chronic Lymphocytic Leukemia: Current Understanding and Evolving Role in Clinical Practice
Treatment of chronic lymphocytic leukemia (CLL) has evolved dramatically during the last decade, from chemoimmunotherapy (...
Update on Small Molecule Targeted Therapies for Acute Myeloid Leukemia
Update on Small Molecule Targeted Therapies for Acute Myeloid Leukemia
The search for effective therapies for the highly heterogenous disease acute myeloid leukemia (AML) has remained elusive. ...
Essential Thrombocythemia in Adolescents and Young Adults: Clinical Aspects, Treatment Options and Unmet Medical Needs
Essential Thrombocythemia in Adolescents and Young Adults: Clinical Aspects, Treatment Options and Unmet Medical Needs
Current treatment of essential thrombocythemia (ET) should primarily prevent thrombo-hemorrhagic events, without increasin...
An Update on Appendiceal Neuroendocrine Tumors
An Update on Appendiceal Neuroendocrine Tumors
The mainstay of appendiceal neuroendocrine neoplasm (aNEN) treatment is surgery, based on simple appendectomy or right-sid...
Early Stage and Locally Advanced Nasopharyngeal Carcinoma Treatment from Present to Future: Where Are We and Where Are We Going?
Early Stage and Locally Advanced Nasopharyngeal Carcinoma Treatment from Present to Future: Where Are We and Where Are We Going?
Nasopharyngeal carcinoma (NPC) is a rare malignancy, endemic in China, that is commonly diagnosed in locally advanced scen...
Recognition and Management of the Long-term Effects of Cranial Radiation
Recognition and Management of the Long-term Effects of Cranial Radiation
Cranial radiation is ubiquitous in the treatment of primary malignant and benign brain tumors as well as brain metastases....
Effects of Opioids on Immune and Endocrine Function in Patients with Cancer Pain
Effects of Opioids on Immune and Endocrine Function in Patients with Cancer Pain
Opioids are an important treatment in managing cancer pain. Uncontrolled pain can be detrimental to function and quality o...
Novel Estrogen Receptor-Targeted Agents for Breast Cancer
Novel Estrogen Receptor-Targeted Agents for Breast Cancer
It has become clear that patients whose cancers have progressed post-CDK4/6 inhibitor therapy (CDK4/6i) are not deriving t...
Management of Functional Pancreatic Neuroendocrine Neoplasms
Management of Functional Pancreatic Neuroendocrine Neoplasms
Functional pancreatic neuroendocrine neoplasms (pNENs) are rare and heterogeneous diseases in terms of both clinical and p...
Which Second-Line Tyrosine Kinase Inhibitor(s) for Chronic Myeloid Leukemia?
Which Second-Line Tyrosine Kinase Inhibitor(s) for Chronic Myeloid Leukemia?
In patients with chronic myeloid leukemia who require second-line tyrosine kinase inhibitor therapy, many options exist. T...
Thrombosis in Acute Myeloid Leukemia: Pathogenesis, Risk Factors and Therapeutic Challenges
Thrombosis in Acute Myeloid Leukemia: Pathogenesis, Risk Factors and Therapeutic Challenges
Prophylaxis and treatment of thrombosis in leukemic patients still represent a major challenge with several clinical quest...
Hepatocellular Carcinoma: a Narrative Review on Current Knowledge and Future Prospects
Hepatocellular Carcinoma: a Narrative Review on Current Knowledge and Future Prospects
Hepatocellular carcinoma is the fourth leading cause of cancer-related deaths worldwide and its associated mortality rate ...
Immunotherapy for Metastatic Triple Negative Breast Cancer: Current Paradigm and Future Approaches
Immunotherapy for Metastatic Triple Negative Breast Cancer: Current Paradigm and Future Approaches
In approximately 15–20% of the patients diagnosed with breast cancer, it comprises the triple negative (TN) subtype,...
New Molecular Insights, and the Role of Systemic Therapies and Collaboration for Treatment of Epithelioid Hemangioendothelioma (EHE)
New Molecular Insights, and the Role of Systemic Therapies and Collaboration for Treatment of Epithelioid Hemangioendothelioma (EHE)
Epithelioid hemangioendothelioma (EHE) is an ultra-rare, translocated vascular sarcoma. EHE can have different clinical pr...
New Developments in Systemic Management for High-Risk Early-Stage Hormone-Receptor-Positive, HER2-Negative Breast Cancer
New Developments in Systemic Management for High-Risk Early-Stage Hormone-Receptor-Positive, HER2-Negative Breast Cancer
For high-risk early-stage hormone-receptor-positive, HER2-negative breast cancer (HR + /HER2 −R...
Current State and Future Directions of EGFR-Directed Therapy in Head and Neck Cancer
Current State and Future Directions of EGFR-Directed Therapy in Head and Neck Cancer
Epidermal growth factor receptor (EGFR) is commonly overexpressed in many head and neck squamous cell carcinomas (HNSCC). ...
Correction to: Antibody–Drug Conjugate Revolution in Breast Cancer: The Road Ahead
Correction to: Antibody–Drug Conjugate Revolution in Breast Cancer: The Road Ahead
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which ...
Available Systemic Treatments and Emerging Therapies for Breast Cancer Brain Metastases
Available Systemic Treatments and Emerging Therapies for Breast Cancer Brain Metastases
In 2023, breast cancer brain metastases (BCBrM) remain a major clinical challenge gaining well-deserved attention. Histori...
Tailoring Treatment for Patients with Inflammatory Breast Cancer
Tailoring Treatment for Patients with Inflammatory Breast Cancer
Inflammatory breast cancer (IBC) is a rare but aggressive subtype of breast cancer that has a propensity for locoregional ...
Guidance for Treating the Older Adults with Colorectal Cancer
Guidance for Treating the Older Adults with Colorectal Cancer
The need for evidence-based data in the rapidly growing group of older patients is vast and more elderly-specific studies ...
Current Management Options for Dyspnea in Cancer Patients
Current Management Options for Dyspnea in Cancer Patients
Dyspnea is one of the most frequent and distressing symptoms in patients with advanced cancer. As dyspnea deteriorates pat...
“Off-the-Shelf” Allogeneic CAR Cell Therapy—Neglected HvG Effect
“Off-the-Shelf” Allogeneic CAR Cell Therapy—Neglected HvG Effect
Chimeric antigen receptor (CAR) cell therapy offers patients with hematological malignancies a new therapeutic option. Tra...
Osteogenic Sarcoma of the Head and Neck: Is Chemotherapy Needed?
Osteogenic Sarcoma of the Head and Neck: Is Chemotherapy Needed?
Head and neck osteosarcoma (HNOS) is a rare subtype of sarcoma that most commonly arises in the mandible or maxilla. Treat...
Advancing Palliative Care Integration in Hematology: Building Upon Existing Evidence
Advancing Palliative Care Integration in Hematology: Building Upon Existing Evidence
Patients with hematologic malignancies and their families are among the most distressed of all those with cancer. Despite ...
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