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Adjuvant Immunotherapy in Patients with Early-Stage Non-small Cell Lung Cancer and Future Directions
Adjuvant Immunotherapy in Patients with Early-Stage Non-small Cell Lung Cancer and Future Directions
While cisplatin-based adjuvant chemotherapy has been the standard of care for the past two decades, the recent introductio...
Targeted Therapies in the Treatment of Uterine Serous Carcinoma
Targeted Therapies in the Treatment of Uterine Serous Carcinoma
Despite the dismal prognosis of uterine serous carcinoma (USC), recent advances in molecular classification and targeted t...
Current Practice in Carcinoid Heart Disease and Burgeoning Opportunities
Current Practice in Carcinoid Heart Disease and Burgeoning Opportunities
Cardiac surgery with tricuspid valve and potentially pulmonic valve replacement at an experienced center is currently the ...
Contemporary Use of Hormonal Therapy in Endometrial Cancer: a Literature Review
Contemporary Use of Hormonal Therapy in Endometrial Cancer: a Literature Review
Most endometrial cancers are estrogen receptor and progesterone receptor positive. Hormonal therapy in endometrial cancer ...
Targeting KRASp.G12C Mutation in Advanced Non-Small Cell Lung Cancer: a New Era Has Begun
Targeting KRASp.G12C Mutation in Advanced Non-Small Cell Lung Cancer: a New Era Has Begun
KRASp.G12C mutation occurs in 12% of newly diagnosed advanced NSCLC and has recently emerged as a positive predictive biom...
Combinations of Chemotherapy and PD-1/PD-L1 Inhibitors in Sarcoma
Combinations of Chemotherapy and PD-1/PD-L1 Inhibitors in Sarcoma
While no PD-1 inhibitor has been FDA approved for use in sarcoma or proven efficacious in a randomized trial, the use of s...
Understanding Cancer Cachexia and Its Implications in Upper Gastrointestinal Cancers
Understanding Cancer Cachexia and Its Implications in Upper Gastrointestinal Cancers
Considerable advances in the investigation and management of oesophagogastric cancer have occurred over the last few decad...
Management and Treatment of Non-small Cell Lung Cancer with MET Alteration and Mechanisms of Resistance
Management and Treatment of Non-small Cell Lung Cancer with MET Alteration and Mechanisms of Resistance
MET-driven tumors are a heterogenous group of non-small cell lung cancers (NSCLC) with activating mutations. Pathologic ac...
Cancer Immunotherapy: Fecal Microbiota Transplantation Brings Light
Cancer Immunotherapy: Fecal Microbiota Transplantation Brings Light
Immunotherapy is revolutionizing tumor treatment by activating the immune response to tumors. Among them, immunotherapy re...
Surgical Principles in the Management of Lung Neuroendocrine Tumors: Open Questions and Controversial Technical Issues
Surgical Principles in the Management of Lung Neuroendocrine Tumors: Open Questions and Controversial Technical Issues
Primary neuroendocrine tumors (NETs) of the lung represent a heterogeneous group of malignancies arising from the endocrin...
Optimal First-Line Therapy for Metastatic Adenocarcinoma of the Esophagus
Optimal First-Line Therapy for Metastatic Adenocarcinoma of the Esophagus
Treatment strategies for esophageal adenocarcinoma patients continue to advance with the generation of more data from clin...
Therapeutic Options for Brain Metastases in Gynecologic Cancers
Therapeutic Options for Brain Metastases in Gynecologic Cancers
Brain metastases (BM) are rare in gynecologic cancers. Overall BM confers a poor prognosis but other factors such as numbe...
Is There Still a Role for Transplant for Patients with Mantle Cell Lymphoma (MCL) in the Era of CAR-T Cell Therapy?
Is There Still a Role for Transplant for Patients with Mantle Cell Lymphoma (MCL) in the Era of CAR-T Cell Therapy?
For years, upfront autologous hematopoietic cell transplant (auto-HCT) has been the standard of care for younger and physi...
New Strategies and Novel Combinations in EGFR TKI-Resistant Non-small Cell Lung Cancer
New Strategies and Novel Combinations in EGFR TKI-Resistant Non-small Cell Lung Cancer
Osimertinib is the current standard-of-care for the first-line treatment of Epidermal Growth Factor Receptor (EGFR)-mutant...
The Role of PARP Inhibitors in Patients with Primary Malignant Central Nervous System Tumors
The Role of PARP Inhibitors in Patients with Primary Malignant Central Nervous System Tumors
Primary malignant central nervous (CNS) tumors are a devastating group of diseases with urgent need for improved treatment...
Beyond Serous: Treatment Options for Rare Endometrial Cancers
Beyond Serous: Treatment Options for Rare Endometrial Cancers
Rare endometrial cancers are high-grade, aggressive malignancies which are often diagnosed at an advanced stage, and accou...
Pathogenic Mechanisms in Acute Myeloid Leukemia
Pathogenic Mechanisms in Acute Myeloid Leukemia
Acute myeloid leukemia (AML) is the most common form of leukemia in adults, leading to the highest number of annual leukem...
The Role of Autophagy in Childhood Central Nervous System Tumors
The Role of Autophagy in Childhood Central Nervous System Tumors
Autophagy is a physiological process that occurs in normal tissues. Under external environmental pressure or internal envi...
Treatment Options for Recurrent Primary CNS Lymphoma
Treatment Options for Recurrent Primary CNS Lymphoma
Primary CNS lymphoma (PCNSL) constitutes a rare extranodal variant of non-Hodgkin lymphoma (NHL) with an annual incidence ...
Regorafenib for the Treatment of Sarcoma
Regorafenib for the Treatment of Sarcoma
Sarcomas are a rare group of tumors with many subtypes, conventionally classified into soft-tissue sarcomas and bone sarco...
BRAF Inhibitor Resistance in Melanoma: Mechanisms and Alternative Therapeutic Strategies
BRAF Inhibitor Resistance in Melanoma: Mechanisms and Alternative Therapeutic Strategies
Melanoma is caused by a variety of somatic mutations, and among these mutations, BRAF mutation occurs most frequently and ...
Antibody-Drug Conjugates for Melanoma and Other Skin Malignancies
Antibody-Drug Conjugates for Melanoma and Other Skin Malignancies
While most skin malignancies are successfully treated with surgical excision, advanced and metastatic skin malignancies st...
Advanced Acral Melanoma Therapies: Current Status and Future Directions
Advanced Acral Melanoma Therapies: Current Status and Future Directions
Melanoma is one of the deadliest malignancies. Its incidence has been significantly increasing in most countries in recent...
Secondary Central Nervous System Lymphoma: Updates in Treatment and Prophylaxis Strategies
Secondary Central Nervous System Lymphoma: Updates in Treatment and Prophylaxis Strategies
Referring to any central nervous system (CNS) involvement with preceding or concurrent systemic disease, secondary CNS lym...
Systemic Therapy Approaches for Breast Cancer Brain and Leptomeningeal Metastases
Systemic Therapy Approaches for Breast Cancer Brain and Leptomeningeal Metastases
Brain metastasis arising from breast cancer is associated with a poor prognosis. Various systemic chemotherapy and targete...
Radiation-Induced Cardiovascular Toxicities
Radiation-Induced Cardiovascular Toxicities
Several seminal papers over the last decade have furthered our recognition of radiation-induced heart disease (RIHD) as an...
Approach to Localized Squamous Cell Cancer of the Esophagus
Approach to Localized Squamous Cell Cancer of the Esophagus
Esophageal cancer is a leading cause of cancer deaths worldwide, with an increasing incidence in recent decades. The major...