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Spatial- and Fourier-domain ptychography for high-throughput bio-imaging
Spatial- and Fourier-domain ptychography for high-throughput bio-imaging
First envisioned for determining crystalline structures, ptychography has become a useful imaging tool for microscopists. ...
Self-assembled ultraflexible probes for long-term neural recordings and neuromodulation
Self-assembled ultraflexible probes for long-term neural recordings and neuromodulation
Ultraflexible microelectrode arrays (MEAs) that can stably record from a large number of neurons after their chronic impla...
Medulloblastoma and high-grade glioma organoids for drug screening, lineage tracing, co-culture and in vivo assay
Medulloblastoma and high-grade glioma organoids for drug screening, lineage tracing, co-culture and in vivo assay
Medulloblastoma and high-grade glioma represent the most aggressive and frequent lethal solid tumors affecting individuals...
Solution-state nuclear magnetic resonance spectroscopy of crystalline cellulosic materials using a direct dissolution ionic liquid electrolyte
Solution-state nuclear magnetic resonance spectroscopy of crystalline cellulosic materials using a direct dissolution ionic liquid electrolyte
Owing to its high sustainable production capacity, cellulose represents a valuable feedstock for the development of more s...
Spiral volumetric optoacoustic tomography for imaging whole-body biodynamics in small animals
Spiral volumetric optoacoustic tomography for imaging whole-body biodynamics in small animals
Fast tracking of biological dynamics across multiple murine organs using the currently commercially available whole-body p...
Molecular-electromechanical system for unamplified detection of trace analytes in biofluids
Molecular-electromechanical system for unamplified detection of trace analytes in biofluids
Biological research and diagnostic applications normally require analysis of trace analytes in biofluids. Although conside...
Encapsulating and stabilizing enzymes using hydrogen-bonded organic frameworks
Encapsulating and stabilizing enzymes using hydrogen-bonded organic frameworks
Enzymes are outstanding natural catalysts with exquisite 3D structures, initiating countless life-sustaining biotransforma...
Generation of iPSC-derived human forebrain organoids assembling bilateral eye primordia
Generation of iPSC-derived human forebrain organoids assembling bilateral eye primordia
Induced pluripotent stem cell-derived brain organoids enable the developmental complexities of the human brain to be decon...
A distal lung organoid model to study interstitial lung disease, viral infection and human lung development
A distal lung organoid model to study interstitial lung disease, viral infection and human lung development
Organoids have been an exciting advancement in stem cell research. Here we describe a strategy for directed differentiatio...
The ClusPro AbEMap web server for the prediction of antibody epitopes
The ClusPro AbEMap web server for the prediction of antibody epitopes
Antibodies play an important role in the immune system by binding to molecules called antigens at their respective epitope...
Click chemistry: a transformative technology in nuclear medicine
Click chemistry: a transformative technology in nuclear medicine
The 2022 Nobel Prize in Chemistry was awarded to Professors K. Barry Sharpless, Morten Meldal and Carolyn Bertozzi for the...
Addendum: Micro-CT acquisition and image processing to track and characterize pulmonary nodules in mice
Author notesThese authors contributed equally: May Zaw Thin, Christopher Moore.Authors and AffiliationsCancer Stem Cell La...
CRISPR-Combo–mediated orthogonal genome editing and transcriptional activation for plant breeding
CRISPR-Combo–mediated orthogonal genome editing and transcriptional activation for plant breeding
CRISPR–Cas nuclease systems, base editors, and CRISPR activation have greatly advanced plant genome engineering. How...
Large-scale F0 CRISPR screens in vivo using MIC-Drop
Large-scale F0 CRISPR screens in vivo using MIC-Drop
The zebrafish is a powerful model system for studying animal development, for modeling genetic diseases, and for large-sca...
Temporally resolved transcriptional recording in E. coli DNA using a Retro-Cascorder
Temporally resolved transcriptional recording in E. coli DNA using a Retro-Cascorder
Biological signals occur over time in living cells. Yet most current approaches to interrogate biology, particularly gene ...
Neural cell isolation from adult macaques for high-throughput analyses and neurosphere cultures
Neural cell isolation from adult macaques for high-throughput analyses and neurosphere cultures
The low number of neural progenitor cells (NPCs) present in the adult and aged primate brains represents a challenge for g...
Full-length circular RNA profiling by nanopore sequencing with CIRI-long
Full-length circular RNA profiling by nanopore sequencing with CIRI-long
Circular RNAs (circRNAs) have important roles in regulating developmental processes and disease progression. As most circR...
Graphene–molecule–graphene single-molecule junctions to detect electronic reactions at the molecular scale
Graphene–molecule–graphene single-molecule junctions to detect electronic reactions at the molecular scale
The ability to measure the behavior of a single molecule during a reaction implies the detection of inherent dynamic and s...
Determining chromatin architecture with Micro Capture-C
Determining chromatin architecture with Micro Capture-C
Micro Capture-C (MCC) is a chromatin conformation capture (3C) method for visualizing reproducible three-dimensional conta...
Z-REX: shepherding reactive electrophiles to specific proteins expressed tissue specifically or ubiquitously, and recording the resultant functional electrophile-induced redox responses in larval fish
Z-REX: shepherding reactive electrophiles to specific proteins expressed tissue specifically or ubiquitously, and recording the resultant functional electrophile-induced redox responses in larval fish
This Protocol Extension describes the adaptation of an existing Protocol detailing the use of targetable reactive electrop...
An operant social self-administration and choice model in mice
An operant social self-administration and choice model in mice
Little is known about how social factors contribute to neurobiology or neuropsychiatric disorders. The use of mice allows ...
Comprehensive isolation of extracellular vesicles and nanoparticles
Comprehensive isolation of extracellular vesicles and nanoparticles
There is an increasing appreciation for the heterogeneous nature of extracellular vesicles (EVs). In addition, two nonvesi...
Addendum: A ‘print–pause–print’ protocol for 3D printing microfluidics using multimaterial stereolithography
Authors and AffiliationsDepartment of Chemical Engineering & Biotechnology, Tech University of Korea, Siheung-si, Repu...
iBEAT V2.0: a multisite-applicable, deep learning-based pipeline for infant cerebral cortical surface reconstruction
iBEAT V2.0: a multisite-applicable, deep learning-based pipeline for infant cerebral cortical surface reconstruction
The human cerebral cortex undergoes dramatic and critical development during early postnatal stages. Benefiting from advan...
Author Correction: Reliable detection of somatic mutations in solid tissues by laser-capture microdissection and low-input DNA sequencing
Author notesPeter Ellis & Robert OsbornePresent address: Inivata Limited, The Glenn Berge Building, Babraham Research ...
cfSNV: a software tool for the sensitive detection of somatic mutations from cell-free DNA
cfSNV: a software tool for the sensitive detection of somatic mutations from cell-free DNA
Cell-free DNA (cfDNA) in blood, viewed as a surrogate for tumor biopsy, has many clinical applications, including diagnosi...
Preparation and quantitative analysis of multicenter luminescence materials for sensing function
Preparation and quantitative analysis of multicenter luminescence materials for sensing function
Luminescent sensing materials are attractive for environmental analysis due to their potential for high selectivity, excel...
Preparation of large biological samples for high-resolution, hierarchical, synchrotron phase-contrast tomography with multimodal imaging compatibility
Preparation of large biological samples for high-resolution, hierarchical, synchrotron phase-contrast tomography with multimodal imaging compatibility
Imaging across different scales is essential for understanding healthy organ morphology and pathophysiological changes. Th...
A flow cytometry-based protocol for syngenic isolation of neurovascular unit cells from mouse and human tissues
A flow cytometry-based protocol for syngenic isolation of neurovascular unit cells from mouse and human tissues
The neurovascular unit (NVU), composed of endothelial cells, pericytes, juxtaposed astrocytes and microglia together with ...
Isocyanide-based multi-component reactions for carrier-free and carrier-bound covalent immobilization of enzymes
Isocyanide-based multi-component reactions for carrier-free and carrier-bound covalent immobilization of enzymes
Strategies for the covalent immobilization of enzymes depend on the type of functional group selected to perform the coupl...
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