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Dexmedetomidine alleviates acute kidney injury in a rat model of veno‐arterial extracorporeal membrane oxygenation
Dexmedetomidine alleviates acute kidney injury in a rat model of veno‐arterial extracorporeal membrane oxygenation
Although extracorporeal membrane oxygenation (ECMO) is an effective technique for life support, the incidence of acute kid...
Exploring timely and safe discharge from ICU: a comparative study of machine learning predictions and clinical practices
Exploring timely and safe discharge from ICU: a comparative study of machine learning predictions and clinical practices
The discharge practices from the intensive care unit exhibit heterogeneity and the recognition of eligible patients for di...
The effects of ultra-selective beta1-antagonism on the metabolic and cytokine profile in septic shock patients receiving noradrenaline: a sub-investigation from the STRESS-L Randomised Study
The effects of ultra-selective beta1-antagonism on the metabolic and cytokine profile in septic shock patients receiving noradrenaline: a sub-investigation from the STRESS-L Randomised Study
The landiolol and organ failure in patients with septic shock (STRESS-L study) included a pre-planned sub-study to assess ...
Impact of hemoadsorption with CytoSorb® on meropenem and piperacillin exposure in critically ill patients in a post-CKRT setup: a single-center, retrospective data analysis
Impact of hemoadsorption with CytoSorb® on meropenem and piperacillin exposure in critically ill patients in a post-CKRT setup: a single-center, retrospective data analysis
CytoSorb® (CS) adsorbent is a hemoadsorption filter for extracorporeal blood purification often integrated into conti...
Capillary refill time paradoxically decreases in a blood loss shock model
Capillary refill time paradoxically decreases in a blood loss shock model
This study aimed to investigate whether changes in capillary refill (CR) time precede macrovascular signs of deterioration...
A murine model of acute and prolonged abdominal sepsis, supported by intensive care, reveals time-dependent metabolic alterations in the heart
A murine model of acute and prolonged abdominal sepsis, supported by intensive care, reveals time-dependent metabolic alterations in the heart
Sepsis-induced cardiomyopathy (SICM) often occurs in the acute phase of sepsis and is associated with increased mortality ...
Translational approach to assess brain injury after cardiac arrest in preclinical models: a narrative review
Translational approach to assess brain injury after cardiac arrest in preclinical models: a narrative review
Our analysis reveals significant discrepancies between preclinical study designs and clinical practice, underscoring the u...
Investigation into the influence of mild hypothermia on regulating ferroptosis through the P53-SLC7A11/GPX4 signaling pathway in sepsis-induced acute lung injury
Investigation into the influence of mild hypothermia on regulating ferroptosis through the P53-SLC7A11/GPX4 signaling pathway in sepsis-induced acute lung injury
Sepsis-induced acute lung injury (S-ALI) significantly contributes to unfavorable clinical outcomes. Emerging evidence sug...
A hands-free carotid Doppler can identify spontaneous circulation without interrupting cardiopulmonary resuscitation: an animal study
A hands-free carotid Doppler can identify spontaneous circulation without interrupting cardiopulmonary resuscitation: an animal study
Identifying spontaneous circulation during cardiopulmonary resuscitation (CPR) is challenging. Current methods, which invo...
Modification in ICU design may influence circadian serum cholinesterase activities: a proof-of-concept pilot study
Modification in ICU design may influence circadian serum cholinesterase activities: a proof-of-concept pilot study
Deficits in cholinergic function are assumed to cause cognitive decline. Studies have demonstrated that changes in serum c...
Lung immune incompetency after mild peritoneal sepsis and its partial restoration by type 1 interferon: a mouse model study
Lung immune incompetency after mild peritoneal sepsis and its partial restoration by type 1 interferon: a mouse model study
Sepsis is commonly associated with acute respiratory distress syndrome (ARDS). Although the exaggerated inflammation may d...
β3-Adrenergic receptor antagonism improves cardiac and vascular functions but did not modulate survival in a murine resuscitated septic shock model
β3-Adrenergic receptor antagonism improves cardiac and vascular functions but did not modulate survival in a murine resuscitated septic shock model
Recent findings suggest that β3-adrenergic receptors (β3-AR) could play a role in the hemodynamic regulation, bu...
Safety of flow-controlled ventilation with positive and negative end-expiratory pressure in a swine model of intracranial hypertension
Safety of flow-controlled ventilation with positive and negative end-expiratory pressure in a swine model of intracranial hypertension
Patients with brain damage often require mechanical ventilation. Although lung-protective ventilation is recommended, the ...
Predictors of VILI risk: driving pressure, 4DPRR and mechanical power ratio—an experimental study
Predictors of VILI risk: driving pressure, 4DPRR and mechanical power ratio—an experimental study
Ventilator-induced lung injury (VILI) is one of the side effects of mechanical ventilation during ARDS; a prerequisite for...
Renal venous flow in different regions of the kidney are different and reflecting different etiologies of venous reflux disorders in septic acute kidney injury: a prospective cohort study
Renal venous flow in different regions of the kidney are different and reflecting different etiologies of venous reflux disorders in septic acute kidney injury: a prospective cohort study
Acute kidney injury (AKI) is a frequent complication of sepsis. While impaired renal venous reflux indicates renal congest...
Human liver stem cells and derived extracellular vesicles protect from sepsis-induced acute lung injury and restore bone marrow myelopoiesis in a murine model of sepsis
Human liver stem cells and derived extracellular vesicles protect from sepsis-induced acute lung injury and restore bone marrow myelopoiesis in a murine model of sepsis
Sepsis is a condition with high mortality and morbidity, characterized by deregulation of the immune response against the ...
Effect of fluid and driving pressure on cyclical “on–off” flow of pulmonary microcirculation during mechanical ventilation
Effect of fluid and driving pressure on cyclical “on–off” flow of pulmonary microcirculation during mechanical ventilation
This study aimed to identify the cyclical “on–off” flow of pulmonary microcirculation during inspiration...
Reply to: The pressure gradient for venous return and its derivatives are ambiguous measures
Reply to: The pressure gradient for venous return and its derivatives are ambiguous measures
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Target-controlled dialysis for antibiotics (TCD-ABx)
Target-controlled dialysis for antibiotics (TCD-ABx)
Effective antimicrobial therapy is an essential part of intensive care medicine and renal replacement therapy is an import...
Open-lung ventilation versus no ventilation during cardiopulmonary bypass in an innovative animal model of heart transplantation
Open-lung ventilation versus no ventilation during cardiopulmonary bypass in an innovative animal model of heart transplantation
Open-lung ventilation during cardiopulmonary bypass (CPB) in patients undergoing heart transplantation (HTx) is a potentia...
Cerebral capillary oxygen diffusion: exploring the concept of intracapillary hemoglobin conformational changes
Cerebral capillary oxygen diffusion: exploring the concept of intracapillary hemoglobin conformational changes
The mechanisms of oxygen diffusion in brain capillaries have not been fully clarified to date. According to the laws of ph...
Assessment of mitochondrial function and its prognostic role in sepsis: a literature review
Assessment of mitochondrial function and its prognostic role in sepsis: a literature review
Sepsis is characterized by a dysregulated and excessive systemic inflammatory response to infection, associated with vascu...
Predictors of intradialytic hypotension in critically ill patients undergoing kidney replacement therapy: a systematic review
Predictors of intradialytic hypotension in critically ill patients undergoing kidney replacement therapy: a systematic review
This systematic review aims to identify predictors of intradialytic hypotension (IDH) in critically ill patients undergoin...
The development of a C5.0 machine learning model in a limited data set to predict early mortality in patients with ARDS undergoing an initial session of prone positioning
The development of a C5.0 machine learning model in a limited data set to predict early mortality in patients with ARDS undergoing an initial session of prone positioning
Acute Respiratory Distress Syndrome (ARDS) has a high morbidity and mortality. One therapy that can decrease mortality is ...
Thermoregulation and survival during sepsis: insights from the cecal ligation and puncture experimental model
Thermoregulation and survival during sepsis: insights from the cecal ligation and puncture experimental model
Sepsis remains a major global health concern due to its high prevalence and mortality. Changes in body temperature (Tb), s...
A new method to predict return of spontaneous circulation by peripheral intravenous analysis during cardiopulmonary resuscitation: a rat model pilot study
A new method to predict return of spontaneous circulation by peripheral intravenous analysis during cardiopulmonary resuscitation: a rat model pilot study
Enhancing venous return during cardiopulmonary resuscitation (CPR) can lead to better hemodynamics and improved outcome af...
The pressure gradient for venous return and its derivatives are ambiguous measures
The pressure gradient for venous return and its derivatives are ambiguous measures
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Lethal versus surviving sepsis phenotypes displayed a partly differential regional expression of neurotransmitters and inflammation and did not modify the blood–brain barrier permeability in female CLP mice
Lethal versus surviving sepsis phenotypes displayed a partly differential regional expression of neurotransmitters and inflammation and did not modify the blood–brain barrier permeability in female CLP mice
Septic encephalopathy is frequent but its pathophysiology is enigmatic. We studied expression of neurotransmitters, inflam...
Mitochondrial DNA in plasma and long-term physical recovery of critically ill patients: an observational study
Mitochondrial DNA in plasma and long-term physical recovery of critically ill patients: an observational study
Post-intensive care syndrome (PICS) poses a notable public health concern, with survivors of critical illness experiencing...
Quantification of pulmonary edema using automated lung segmentation on computed tomography in mechanically ventilated patients with acute respiratory distress syndrome
Quantification of pulmonary edema using automated lung segmentation on computed tomography in mechanically ventilated patients with acute respiratory distress syndrome
Quantification of pulmonary edema in patients with acute respiratory distress syndrome (ARDS) by chest computed tomography...
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