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Intradialytic acute brain injury
Intradialytic acute brain injury
The researchers used intradialytic brain MRI, diffusion tensor imaging and proton magnetic resonance spectroscopy to inves...
Ferroptotic mechanisms and therapeutic targeting of iron metabolism and lipid peroxidation in the kidney
Ferroptotic mechanisms and therapeutic targeting of iron metabolism and lipid peroxidation in the kidney
Ferroptosis is a mechanism of regulated necrotic cell death characterized by iron-dependent, lipid peroxidation-driven mem...
The cilia mechanosensation debate gets (bio)physical
The cilia mechanosensation debate gets (bio)physical
Two studies have applied a mechanical stimulus directly to a cilium, independent of a chemical signal, and demonstrated th...
The role of lysosomes in metabolic and autoimmune diseases
The role of lysosomes in metabolic and autoimmune diseases
Lysosomes are catabolic organelles that contribute to the degradation of intracellular constituents through autophagy and ...
Mechanism of B cell survival in lupus nephritis
Mechanism of B cell survival in lupus nephritis
Kidney infiltration of immune cells is associated with disease severity in patients with lupus nephritis; however, the eff...
Experimental evidence for a pathogenic role of anti-PLA2R1 antibodies in membranous nephropathy
Experimental evidence for a pathogenic role of anti-PLA2R1 antibodies in membranous nephropathy
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SGLT2 inhibitors attenuate alterations of kidney metabolic pathways in youth-onset T2DM
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Reply to ‘Use of convalescent plasma in the treatment of COVID-19’
Competing interests H.A.-S. disclosures include consultancy (Agios, Dova/Sobi, a...
Use of convalescent plasma in the treatment of COVID-19
We read with interest the Review “Therapeutic advances in COVID-19” by Murakami et al.1 and congratulate ...
Bridging the gap of referral to nephrology care
Optimal referral of patients who are at risk of kidney failure to nephrologists could improve their long-term outcomes. Va...
Targeting iron uptake to correct T cell dysfunction
Targeting iron uptake to correct T cell dysfunction
The researchers used lupus-prone SLE1.2.3 mice that, like patients with SLE, harbour T cells with high levels of intracell...
Sepsis-associated acute kidney injury: consensus report of the 28th Acute Disease Quality Initiative workgroup
Sepsis-associated acute kidney injury: consensus report of the 28th Acute Disease Quality Initiative workgroup
Sepsis-associated acute kidney injury (SA-AKI) is common in critically ill patients and is strongly associated with advers...
Author Correction: Therapeutic advances in COVID-19
Division of Renal Medicine, Brigham and Women’s Hospital, Boston, MA, USANaoka Murakami, Robert Hayden & David E. Leaf...
Disaster preparedness for patients with kidney disease
Access to essential medical care can be compromised by social disruptions (such as riots and labour strikes), armed confli...
Fasting induces structural and functional changes in the peritoneal membrane
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VPS34 functions in the proximal tubule
VPS34 functions in the proximal tubule
VPS34 is a PI3K that is involved in endolysosomal and cellular processes, such as vesicle trafficking and...
Pathological consequences of DNA damage in the kidney
Pathological consequences of DNA damage in the kidney
DNA lesions that evade repair can lead to mutations that drive the development of cancer, and cellular responses to DNA da...
Targeting glutamine use in RCC
Targeting glutamine use in RCC
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Hope for resistant hypertension through BrigHTN and PRECISION
Hope for resistant hypertension through BrigHTN and PRECISION
An estimated 10–15% of individuals with hypertension are resistant to available antihypertensive therapies. Findings...
Consequences of famine and malnourishment on kidney health
Adequate nutrition is essential for kidney health; however, attempts to improve nutrition and food security have been hind...
Climate change-fuelled natural disasters and chronic kidney disease: a call for action
Climate change-fuelled natural disasters and chronic kidney disease: a call for action
People with kidney disease are particularly vulnerable to the impacts of natural disasters and extreme weather events. As ...
Environmental pollution, heat stress and kidney health: a need for integrated assessment
Thousands of environmental chemicals are used globally. However, despite clear evidence of their adverse effects on the ki...
Heat and health inequity: acting on determinants of health to promote heat justice
Climate change is increasing global temperatures and causing more frequent and severe extreme heat events. The resulting a...
Exercise and chronic kidney disease: potential mechanisms underlying the physiological benefits
Exercise and chronic kidney disease: potential mechanisms underlying the physiological benefits
Increasing evidence indicates that exercise has beneficial effects on chronic inflammation, cardiorespiratory function, mu...
Informing clinical decision making during a pandemic — a call for better preparedness
The COVID-19 pandemic exposed flaws in the ability of the nephrology community to efficiently inform clinical decision mak...
The impact of intrauterine growth restriction and prematurity on nephron endowment
The impact of intrauterine growth restriction and prematurity on nephron endowment
In humans born at term, maximal nephron number is reached by the time nephrogenesis is completed — at approximately ...
The role of immune cells and mediators in preeclampsia
The role of immune cells and mediators in preeclampsia
Preeclampsia is a hypertensive disorder of major concern in pregnancy than can lead to intrauterine growth restriction, pl...
The gut microbiome and hypertension
The gut microbiome and hypertension
A large body of evidence has emerged in the past decade supporting a role for the gut microbiome in the regulation of bloo...
Clinical practice recommendations for primary hyperoxaluria: an expert consensus statement from ERKNet and OxalEurope
Clinical practice recommendations for primary hyperoxaluria: an expert consensus statement from ERKNet and OxalEurope
Primary hyperoxaluria (PH) is an inherited disorder that results from the overproduction of endogenous oxalate, leading to...
Regulation of FGF23 production and phosphate metabolism by bone–kidney interactions
Regulation of FGF23 production and phosphate metabolism by bone–kidney interactions
The bone-derived hormone fibroblast growth factor 23 (FGF23) functions in concert with parathyroid hormone (PTH) and the a...
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