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Natural killer cell-mediated innate microvascular rejection
Natural killer cell-mediated innate microvascular rejection
Graft rejection is traditionally attributed to adaptive immune cells that recognize donor-specific alloantigens, with inna...
Healthy ageing and the kidney — lessons from centenarians
Healthy ageing and the kidney — lessons from centenarians
Centenarians — who are a putative model of healthy longevity — often have a low risk of cardiovascular disease...
Unlocking the benefits of transplantation with kidneys from older donors
Kidneys from older donors might improve the quality of life and survival of patients with kidney failure, yet these organs...
Pulmonary hypertension and chronic kidney disease: prevalence, pathophysiology and outcomes
Pulmonary hypertension and chronic kidney disease: prevalence, pathophysiology and outcomes
Pulmonary hypertension (PH) is common in patients with chronic kidney disease (CKD) or kidney failure, with an estimated p...
Gene regulatory networks in disease and ageing
Gene regulatory networks in disease and ageing
The precise control of gene expression is required for the maintenance of cellular homeostasis and proper cellular functio...
Chronic kidney disease in American Indians and Alaska Natives
Chronic kidney disease in American Indians and Alaska Natives
American Indian and Alaska Native peoples have low life expectancy and a disproportionate disease burden (including of chr...
Home monitoring of patients with chronic kidney disease
Home monitoring of patients with chronic kidney disease
The increasing prevalence of chronic kidney disease (CKD) is placing a growing burden on healthcare systems, which results...
Cystatin C and the misdiagnosis of CKD in older adults
Cystatin C and the misdiagnosis of CKD in older adults
The use of cystatin C-inclusive equations will continue to propagate the unnecessary overdiagnosis of chronic kidney disea...
Remodelling by macula densa cells
Cells of the macula densa (MD) sense changes in tubular fluid to control functions such as renal blood flow and renin rele...
Mutational signatures of ccRCC vary between geographical regions
Known risk factors, such as smoking, obesity and hypertension, do not explain variations in the incidence of clear cell re...
VHL loss attracts immune cells to tumours
VHL loss attracts immune cells to tumours
VHL loss is common in clear cell renal cell carcinoma (ccRCC) and triggers a pseudohypoxic state in mutated cells. A study...
Sleep disorders in chronic kidney disease
Sleep disorders in chronic kidney disease
Sleep disorders are highly prevalent in chronic kidney disease (CKD) but are often under-recognized. Restless legs syndrom...
Kidney health within the broader non-communicable disease agenda
Kidney disease is strongly linked with cardiovascular diseases, hypertension, diabetes, infections and other health condit...
Podocyte-targeted therapies — progress and future directions
Podocyte-targeted therapies — progress and future directions
Podocytes are the key target cells for injury across the spectrum of primary and secondary proteinuric kidney disorders, w...
A patient perspective on kidney disease in the public health agenda
Chronic kidney disease is a life-changing diagnosis for millions of people worldwide, as the risk of disease progression a...
Spatial transcriptomics in health and disease
Spatial transcriptomics in health and disease
The ability to localize hundreds of macromolecules to discrete locations, structures and cell types in a tissue is a power...
Role of the gut microbiota in the pathogenesis of IgA nephropathy
Role of the gut microbiota in the pathogenesis of IgA nephropathy
The microbiome can modulate immune responses and has an important effect on human health, but its potential causal role in...
Progression and outcomes of rare kidney diseases
Progression and outcomes of rare kidney diseases
To describe kidney and patient outcomes for individuals with rare diseases in the UK, Gale and colleagues analysed data fr...
Applications of SGLT2 inhibitors beyond glycaemic control
Applications of SGLT2 inhibitors beyond glycaemic control
Sodium–glucose cotransporter 2 (SGLT2) inhibitors were initially developed for their glucose-lowering effects and ha...
Post-translational modifications in kidney diseases and associated cardiovascular risk
Post-translational modifications in kidney diseases and associated cardiovascular risk
Patients with chronic kidney disease (CKD) are at an increased cardiovascular risk compared with the general population, w...
Considerations of sex as a binary variable in clinical algorithms
Clinical algorithms that are used to guide medical decision-making often include sex as a variable. However, binary consid...
Not every organ ticks the same
Not every organ ticks the same
A new study describes the development of proteomics-based ageing clocks that calculate the biological age of specific orga...
Immune mechanisms in the pathophysiology of hypertension
Immune mechanisms in the pathophysiology of hypertension
Hypertension is a leading risk factor for morbidity and mortality worldwide. Despite current anti-hypertensive therapies, ...
Calcium signalling and transport in the kidney
Calcium signalling and transport in the kidney
The kidney plays a pivotal role in regulating calcium levels within the body. Approximately 98% of the filtered calcium is...
Thiazides in kidney transplant recipients: skin in the game
Thiazides in kidney transplant recipients: skin in the game
Clinical trial data suggest that thiazides and thiazide-like drugs could be beneficial for blood-pressure lowering in pati...
Epithelial cell states associated with kidney and allograft injury
Epithelial cell states associated with kidney and allograft injury
The kidney epithelium, with its intricate arrangement of highly specialized cell types, constitutes the functional core of...
A new era in the science and care of kidney diseases
A new era in the science and care of kidney diseases
Notable progress in basic, translational and clinical nephrology research has been made over the past five decades. Noneth...
The global landscape of kidney registries: immense challenges and unique opportunities
The global landscape of kidney registries: immense challenges and unique opportunities
Kidney registries are essential to understanding the burden of kidney disease and facilitating the development of sustaina...
Kidney disease: a global health priority
Kidney disease: a global health priority
The prevalence of kidney disease and its associated morbidity and mortality continue to rise. This crisis cannot be tackle...
Combination therapy for kidney disease in people with diabetes mellitus
Combination therapy for kidney disease in people with diabetes mellitus
Diabetic kidney disease (DKD), defined as co-existing diabetes and chronic kidney disease in the absence of other clear ca...
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