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Dare to HOPE: a step closer to HIV+-to-HIV+ kidney transplantation as standard of care
New data demonstrate that in people with HIV infection, transplantation outcomes with HIV-positive donor kidneys are not i...
Steps forward in the treatment of IgA nephropathy
A turning point in the treatment of IgA nephropathy has been marked by several new publications that describe promising ou...
Long-term lessons from EMPA-KIDNEY
Sodium–glucose co-transporter 2 inhibitors have revolutionized the management of chronic kidney disease. Ho...
Mitochondrial dysfunction has a central role in diabetic kidney disease
Mitochondrial dysfunction has a central role in diabetic kidney disease
Diabetic kidney disease (DKD), the most common cause of chronic kidney disease, is primarily caused by metabolic dysfuncti...
Publisher Correction: Glycosylation in health and disease
Author notesThese authors contributed equally: Colin Reily, Tyler J. Stewart.Authors and AffiliationsDepartment of Medicin...
New insights into kidney crosstalk with distant organs
New insights into kidney crosstalk with distant organs
Inter-organ interactions are critical for homeostasis and proper organ functioning. Several studies published in 2024 have...
Interplay between periodontitis and chronic kidney disease
Interplay between periodontitis and chronic kidney disease
Periodontitis is a ubiquitous chronic inflammatory disease affecting the supporting tissues of the teeth and is a major ca...
Crosstalk between glomeruli and tubules
Crosstalk between glomeruli and tubules
Models of kidney injury have classically concentrated on glomeruli as the primary site of injury leading to glomeruloscler...
Endothelin receptor antagonists in chronic kidney disease
Endothelin receptor antagonists in chronic kidney disease
Endothelin-1 is a potent vasoconstrictor that has diverse physiological functions in the kidney, including in the regulati...
Integrins in the kidney — beyond the matrix
Integrins in the kidney — beyond the matrix
The development and proper functioning of the kidney is dependent on the interaction of kidney cells with the surrounding ...
Immune–stromal interplay shapes kidney function in health and disease
Immune–stromal interplay shapes kidney function in health and disease
New studies have revealed a novel homeostatic clearance function for medullary macrophages, unveiled roles for innate lymp...
Contribution of APOL1 variants to CKD risk in West Africans
The G1 and G2 APOL1 risk alleles are important risk factors for chronic kidney disease (CKD) among Black Americans; howeve...
Consequence of microvascular inflammation in transplantation
Consequence of microvascular inflammation in transplantation
Recognition that allograft microvascular inflammation can occur in the absence of circulating donor-specific anti-HLA anti...
Advancing gender equity to improve kidney care for women: a patient perspective
Women living with kidney disease are exposed to several sex and gender gaps in the clinical practice of standard hemodialy...
Collagen formation, function and role in kidney disease
Collagen formation, function and role in kidney disease
Highly abundant in mammals, collagens define the organization of tissues and participate in cell signalling. Most...
Kidney disease and reproductive health
Kidney disease and reproductive health
Understanding the relationship between reproductive health and kidney function is important to provide holistic care for p...
ECM remodelling by ADAMTS12 in fibrosis
Fibrosis results from the continuous deposition of extracellular matrix (ECM) by fibroblasts in response to injurious stim...
Treating AAV by targeting T cell responses
Treating AAV by targeting T cell responses
Glucocorticoids are currently used to induce remission in patients with antineutrophil cytoplasmic antibody glomerulonephr...
Bacteria caught in neutrophil and UMOD traps in urine
Bacteria caught in neutrophil and UMOD traps in urine
Several mechanisms prevent the ascent of uropathogenic bacteria from the bladder to the kidney, which can lead to pyelonep...
International expert consensus statement on the diagnosis and management of congenital nephrogenic diabetes insipidus (arginine vasopressin resistance)
International expert consensus statement on the diagnosis and management of congenital nephrogenic diabetes insipidus (arginine vasopressin resistance)
Congenital nephrogenic diabetes insipidus (NDI; also known as arginine vasopressin resistance) is a rare inherited disorde...
A guide to gene–disease relationships in nephrology
A guide to gene–disease relationships in nephrology
The use of next-generation sequencing technologies such as exome and genome sequencing in research and clinical care has t...
A guide to studying 3D genome structure and dynamics in the kidney
A guide to studying 3D genome structure and dynamics in the kidney
The human genome is tightly packed into the 3D environment of the cell nucleus. Rapidly evolving and sophisticated methods...
Multidisciplinary collaboration to improve neonatal kidney health
Multidisciplinary collaboration to improve neonatal kidney health
The Neonatal Kidney Collaborative is a multidisciplinary initiative that aims to improve neonatal kidney health. By unitin...
Renal nerves in physiology, pathophysiology and interoception
Renal nerves in physiology, pathophysiology and interoception
Sympathetic efferent renal nerves have key roles in the regulation of kidney function and blood pressure. Increased renal ...
New AAV vector targets glomerular endothelial cells
New AAV vector targets glomerular endothelial cells
Gene therapy is increasingly used in the clinic, but specific delivery to kidney cells remains an important obstacle to br...
Risk of kidney failure among patients with genetic kidney diseases
Monogenic alterations cause a variety of paediatric kidney diseases; however, insights into their association with clinica...
Spatial transcriptomics of acute kidney injury
Improved understanding of the cellular changes and interactions that occur in the kidney following injury may help to eluc...
Metabolism at the crossroads of inflammation and fibrosis in chronic kidney disease
Metabolism at the crossroads of inflammation and fibrosis in chronic kidney disease
Chronic kidney disease (CKD), defined as persistent (>3 months) kidney functional loss, has a growing prevalence (&...
Polygenic scores and their applications in kidney disease
Polygenic scores and their applications in kidney disease
Genome-wide association studies (GWAS) have uncovered thousands of risk variants that individually have small effects on t...
The pathogenesis of IgA nephropathy and implications for treatment
The pathogenesis of IgA nephropathy and implications for treatment
IgA nephropathy (IgAN) is a common form of primary glomerulonephritis and represents an important cause of chronic kidney ...
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