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Considerations of sex as a binary variable in clinical algorithms
Clinical algorithms that are used to guide medical decision-making often include sex as a variable. However, binary consid...
Not every organ ticks the same
Not every organ ticks the same
A new study describes the development of proteomics-based ageing clocks that calculate the biological age of specific orga...
Immune mechanisms in the pathophysiology of hypertension
Immune mechanisms in the pathophysiology of hypertension
Hypertension is a leading risk factor for morbidity and mortality worldwide. Despite current anti-hypertensive therapies, ...
Calcium signalling and transport in the kidney
Calcium signalling and transport in the kidney
The kidney plays a pivotal role in regulating calcium levels within the body. Approximately 98% of the filtered calcium is...
Thiazides in kidney transplant recipients: skin in the game
Thiazides in kidney transplant recipients: skin in the game
Clinical trial data suggest that thiazides and thiazide-like drugs could be beneficial for blood-pressure lowering in pati...
Epithelial cell states associated with kidney and allograft injury
Epithelial cell states associated with kidney and allograft injury
The kidney epithelium, with its intricate arrangement of highly specialized cell types, constitutes the functional core of...
A new era in the science and care of kidney diseases
A new era in the science and care of kidney diseases
Notable progress in basic, translational and clinical nephrology research has been made over the past five decades. Noneth...
The global landscape of kidney registries: immense challenges and unique opportunities
The global landscape of kidney registries: immense challenges and unique opportunities
Kidney registries are essential to understanding the burden of kidney disease and facilitating the development of sustaina...
Kidney disease: a global health priority
Kidney disease: a global health priority
The prevalence of kidney disease and its associated morbidity and mortality continue to rise. This crisis cannot be tackle...
Combination therapy for kidney disease in people with diabetes mellitus
Combination therapy for kidney disease in people with diabetes mellitus
Diabetic kidney disease (DKD), defined as co-existing diabetes and chronic kidney disease in the absence of other clear ca...
Chronic kidney disease and the global public health agenda: an international consensus
Chronic kidney disease and the global public health agenda: an international consensus
Early detection is a key strategy to prevent kidney disease, its progression and related complications, but numerous studi...
Sex differences in kidney metabolism and DKD
Sex differences in kidney metabolism and DKD
The epidemiology of diabetic kidney disease (DKD) differs by sex, with a greater risk of kidney failure in men. New data s...
Clonal haematopoiesis and AKI
Clonal haematopoiesis of indeterminate potential (CHIP) arises from the clonal expansion of a mutated haematopoietic stem ...
Switching off SOX9 for epithelial recovery after AKI
Switching off SOX9 for epithelial recovery after AKI
In acute kidney injury (AKI), dysregulated tissue regeneration can promote fibrosis and chronic kidney disease. Sustained ...
Drug stewardship in chronic kidney disease to achieve effective and safe medication use
Drug stewardship in chronic kidney disease to achieve effective and safe medication use
People living with chronic kidney disease (CKD) often experience multimorbidity and require polypharmacy. Kidney dysfuncti...
Role of biophysics and mechanobiology in podocyte physiology
Role of biophysics and mechanobiology in podocyte physiology
Podocytes form the backbone of the glomerular filtration barrier and are exposed to various mechanical forces throughout t...
Clinical practice recommendations for kidney involvement in tuberous sclerosis complex: a consensus statement by the ERKNet Working Group for Autosomal Dominant Structural Kidney Disorders and the ERA Genes & Kidney Working Group
Clinical practice recommendations for kidney involvement in tuberous sclerosis complex: a consensus statement by the ERKNet Working Group for Autosomal Dominant Structural Kidney Disorders and the ERA Genes & Kidney Working Group
Tuberous sclerosis complex (TSC) is an autosomal dominant disorder characterized by the presence of proliferative lesions ...
Innovating dialysis through computational modelling of hollow-fibre haemodialysers
Haemodialyser technology has not advanced much in decades, despite its unresolved shortcomings. Sophisticated new computat...
The renal glucagon receptor is essential to kidney metabolic and homeostatic functions
Kidney glucagon receptors (GCGRs) are expressed along the nephron and downregulated in chronic kidney disease (CKD); howev...
A CAAR NK cell approach to eliminate pathogenic autoantibody-secreting cells
A CAAR NK cell approach to eliminate pathogenic autoantibody-secreting cells
Binding of autoantibodies to autoantigens expressed on podocytes causes membranous nephropathy. New findings suggest that ...
Pericyte–stem cell crosstalk in ccRCC
The cells that surround tumours can influence tumour growth and response to therapy. In new research, ChuanJie Zhang and c...
Organ trafficking — a continuing challenge
Global inequities and inequalities, human and health-care crises, transplantation successes in the face of limited organ a...
Physiological principles underlying the kidney targeting of renal nanomedicines
Physiological principles underlying the kidney targeting of renal nanomedicines
Kidney disease affects more than 10% of the global population and is associated with considerable morbidity and mortality,...
Long-term health outcomes associated with hydration status
Long-term health outcomes associated with hydration status
Body water balance is determined by fundamental homeostatic mechanisms that maintain stable volume, osmolality and the com...
Sirtuins in kidney health and disease
Sirtuins in kidney health and disease
Sirtuins (SIRTs) are putative regulators of lifespan in model organisms. Since the initial discovery that SIRTs could prom...
Macrophages clean out the tubules
Macrophages clean out the tubules
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obta...
Effects of SGLT2 inhibitors on the metabolic environment and uraemic toxins
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obta...
Design of a renal-sparing antifungal
Design of a renal-sparing antifungal
AmB kills fungi through the formation of large sponge-like aggregates that remove ergosterol from the cell membrane of fun...
A united vision for cardiovascular–kidney–metabolic health
Improved understanding of the interrelated nature of cardiovascular, kidney and metabolic (CKM) health, the development of...
The multifaceted links between hearing loss and chronic kidney disease
The multifaceted links between hearing loss and chronic kidney disease
Hearing loss affects nearly 1.6 billion people and is the third-leading cause of disability worldwide. Chronic kidney dise...
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