SCI时时刷

search
+
Pathological mechanisms of kidney disease in ageing
Pathological mechanisms of kidney disease in ageing
The kidney is a metabolically active organ that requires energy to drive processes such as tubular reabsorption and secret...
Avenciguat reduces albuminuria in patients with chronic kidney disease
A new study reports a beneficial effect of avenciguat — a novel, nitric oxide (NO)-independent, soluble guanylate cyclase ...
Regulation of kidney fibrosis by ILC3s via a gut–kidney axis
Regulation of kidney fibrosis by ILC3s via a gut–kidney axis
Innate lymphoid cells (ILCs) are lymphocytes that regulate immune responses. Little is known about these cells in the kidn...
The role of antibody glycosylation in autoimmune and alloimmune kidney diseases
The role of antibody glycosylation in autoimmune and alloimmune kidney diseases
Immunoglobulin glycosylation is a pivotal mechanism that drives the diversification of antibody functions. The composition...
Application of spatial-omics to the classification of kidney biopsy samples in transplantation
Application of spatial-omics to the classification of kidney biopsy samples in transplantation
Improvement of long-term outcomes through targeted treatment is a primary concern in kidney transplant medicine. Currently...
Treatment of chronic kidney disease in older populations
Treatment of chronic kidney disease in older populations
As the world population ages, an expected increase in the prevalence of chronic kidney disease (CKD) among older individua...
Deep learning applications in digital pathology
Deep Learning (DL) holds great promise to improve patient outcomes by improving the precision and speed of disease diagnos...
The impact of population ageing on the burden of chronic kidney disease
The impact of population ageing on the burden of chronic kidney disease
The burden of chronic kidney disease (CKD) and its risk factors are projected to rise in parallel with the rapidly ageing ...
A pre-specified analysis of the SELECT trial suggests a kidney benefit of semaglutide in patients without diabetes
Recent data from a pre-specified analysis of the SELECT trial show a beneficial effect of the glucagon-like peptide-1 rece...
Natural killer cell-mediated innate microvascular rejection
Natural killer cell-mediated innate microvascular rejection
Graft rejection is traditionally attributed to adaptive immune cells that recognize donor-specific alloantigens, with inna...
Healthy ageing and the kidney — lessons from centenarians
Healthy ageing and the kidney — lessons from centenarians
Centenarians — who are a putative model of healthy longevity — often have a low risk of cardiovascular disease...
Unlocking the benefits of transplantation with kidneys from older donors
Kidneys from older donors might improve the quality of life and survival of patients with kidney failure, yet these organs...
Pulmonary hypertension and chronic kidney disease: prevalence, pathophysiology and outcomes
Pulmonary hypertension and chronic kidney disease: prevalence, pathophysiology and outcomes
Pulmonary hypertension (PH) is common in patients with chronic kidney disease (CKD) or kidney failure, with an estimated p...
Gene regulatory networks in disease and ageing
Gene regulatory networks in disease and ageing
The precise control of gene expression is required for the maintenance of cellular homeostasis and proper cellular functio...
Chronic kidney disease in American Indians and Alaska Natives
Chronic kidney disease in American Indians and Alaska Natives
American Indian and Alaska Native peoples have low life expectancy and a disproportionate disease burden (including of chr...
Home monitoring of patients with chronic kidney disease
Home monitoring of patients with chronic kidney disease
The increasing prevalence of chronic kidney disease (CKD) is placing a growing burden on healthcare systems, which results...
Cystatin C and the misdiagnosis of CKD in older adults
Cystatin C and the misdiagnosis of CKD in older adults
The use of cystatin C-inclusive equations will continue to propagate the unnecessary overdiagnosis of chronic kidney disea...
Remodelling by macula densa cells
Cells of the macula densa (MD) sense changes in tubular fluid to control functions such as renal blood flow and renin rele...
Mutational signatures of ccRCC vary between geographical regions
Known risk factors, such as smoking, obesity and hypertension, do not explain variations in the incidence of clear cell re...
VHL loss attracts immune cells to tumours
VHL loss attracts immune cells to tumours
VHL loss is common in clear cell renal cell carcinoma (ccRCC) and triggers a pseudohypoxic state in mutated cells. A study...
Sleep disorders in chronic kidney disease
Sleep disorders in chronic kidney disease
Sleep disorders are highly prevalent in chronic kidney disease (CKD) but are often under-recognized. Restless legs syndrom...
Kidney health within the broader non-communicable disease agenda
Kidney disease is strongly linked with cardiovascular diseases, hypertension, diabetes, infections and other health condit...
Podocyte-targeted therapies — progress and future directions
Podocyte-targeted therapies — progress and future directions
Podocytes are the key target cells for injury across the spectrum of primary and secondary proteinuric kidney disorders, w...
A patient perspective on kidney disease in the public health agenda
Chronic kidney disease is a life-changing diagnosis for millions of people worldwide, as the risk of disease progression a...
Spatial transcriptomics in health and disease
Spatial transcriptomics in health and disease
The ability to localize hundreds of macromolecules to discrete locations, structures and cell types in a tissue is a power...
Role of the gut microbiota in the pathogenesis of IgA nephropathy
Role of the gut microbiota in the pathogenesis of IgA nephropathy
The microbiome can modulate immune responses and has an important effect on human health, but its potential causal role in...
Progression and outcomes of rare kidney diseases
Progression and outcomes of rare kidney diseases
To describe kidney and patient outcomes for individuals with rare diseases in the UK, Gale and colleagues analysed data fr...
Applications of SGLT2 inhibitors beyond glycaemic control
Applications of SGLT2 inhibitors beyond glycaemic control
Sodium–glucose cotransporter 2 (SGLT2) inhibitors were initially developed for their glucose-lowering effects and ha...
Post-translational modifications in kidney diseases and associated cardiovascular risk
Post-translational modifications in kidney diseases and associated cardiovascular risk
Patients with chronic kidney disease (CKD) are at an increased cardiovascular risk compared with the general population, w...
Considerations of sex as a binary variable in clinical algorithms
Clinical algorithms that are used to guide medical decision-making often include sex as a variable. However, binary consid...
阅读更多
format_indent_increase