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Approaches to raise awareness of CKD among patients and the general population
Approaches to raise awareness of CKD among patients and the general population
Improved awareness of chronic kidney disease (CKD) is vital to enable at-risk individuals to benefit from new therapies. I...
Clinical practice recommendations for the diagnosis and management of X-linked hypophosphataemia
Clinical practice recommendations for the diagnosis and management of X-linked hypophosphataemia
X-linked hypophosphataemia (XLH) is a rare metabolic bone disorder caused by pathogenic variants in the PHEX gene, which i...
Managing risk factors and early intervention for chronic kidney disease
The high global burden of kidney disease highlights an urgent need for early diagnosis and the implementation of intervent...
Chronic kidney disease screening in LMICs: benefits and challenges
Chronic kidney disease (CKD) satisfies established criteria for screening. Although the economic burden of screening is su...
Multifaceted innovations needed to advance transplant nephrology
Multifaceted innovations needed to advance transplant nephrology
Over the past year, several new research insights and policy changes have advanced the field of kidney transplantation: ki...
Diuretics in patients with chronic kidney disease
Diuretics in patients with chronic kidney disease
Diuretic drugs act on electrolyte transporters in the kidney to induce diuresis and are often used in chronic kidney disea...
Trained immunity: from kidney failure to organ transplantation
Trained immunity: from kidney failure to organ transplantation
Innate immune memory represents a barrier to successful kidney transplantation. The discovery that uraemic toxins in peopl...
Protein handling in kidney tubules
Protein handling in kidney tubules
The kidney proximal tubule reabsorbs and degrades filtered plasma proteins to reclaim valuable nutrients and maintain body...
A golden year of innovative kidney disease therapeutics
A golden year of innovative kidney disease therapeutics
In 2024, a plethora of novel therapeutic strategies for kidney disease progressed to clinical trials, including an RNA int...
Insights into the mechanisms of fibrosis and progressive kidney injury
Insights into the mechanisms of fibrosis and progressive kidney injury
Progression of chronic kidney disease to kidney fibrosis is a key challenge in nephrology. Several contributions from the ...
Roles of sensory receptors in non-sensory organs: the kidney and beyond
Roles of sensory receptors in non-sensory organs: the kidney and beyond
Olfactory receptors (ORs), taste receptors and opsins are well-known for their pivotal roles in mediating the senses of sm...
Dare to HOPE: a step closer to HIV+-to-HIV+ kidney transplantation as standard of care
New data demonstrate that in people with HIV infection, transplantation outcomes with HIV-positive donor kidneys are not i...
Steps forward in the treatment of IgA nephropathy
A turning point in the treatment of IgA nephropathy has been marked by several new publications that describe promising ou...
Long-term lessons from EMPA-KIDNEY
Sodium–glucose co-transporter 2 inhibitors have revolutionized the management of chronic kidney disease. Ho...
Mitochondrial dysfunction has a central role in diabetic kidney disease
Mitochondrial dysfunction has a central role in diabetic kidney disease
Diabetic kidney disease (DKD), the most common cause of chronic kidney disease, is primarily caused by metabolic dysfuncti...
Publisher Correction: Glycosylation in health and disease
Author notesThese authors contributed equally: Colin Reily, Tyler J. Stewart.Authors and AffiliationsDepartment of Medicin...
New insights into kidney crosstalk with distant organs
New insights into kidney crosstalk with distant organs
Inter-organ interactions are critical for homeostasis and proper organ functioning. Several studies published in 2024 have...
Interplay between periodontitis and chronic kidney disease
Interplay between periodontitis and chronic kidney disease
Periodontitis is a ubiquitous chronic inflammatory disease affecting the supporting tissues of the teeth and is a major ca...
Crosstalk between glomeruli and tubules
Crosstalk between glomeruli and tubules
Models of kidney injury have classically concentrated on glomeruli as the primary site of injury leading to glomeruloscler...
Endothelin receptor antagonists in chronic kidney disease
Endothelin receptor antagonists in chronic kidney disease
Endothelin-1 is a potent vasoconstrictor that has diverse physiological functions in the kidney, including in the regulati...
Integrins in the kidney — beyond the matrix
Integrins in the kidney — beyond the matrix
The development and proper functioning of the kidney is dependent on the interaction of kidney cells with the surrounding ...
Immune–stromal interplay shapes kidney function in health and disease
Immune–stromal interplay shapes kidney function in health and disease
New studies have revealed a novel homeostatic clearance function for medullary macrophages, unveiled roles for innate lymp...
Contribution of APOL1 variants to CKD risk in West Africans
The G1 and G2 APOL1 risk alleles are important risk factors for chronic kidney disease (CKD) among Black Americans; howeve...
Consequence of microvascular inflammation in transplantation
Consequence of microvascular inflammation in transplantation
Recognition that allograft microvascular inflammation can occur in the absence of circulating donor-specific anti-HLA anti...
Advancing gender equity to improve kidney care for women: a patient perspective
Women living with kidney disease are exposed to several sex and gender gaps in the clinical practice of standard hemodialy...
Collagen formation, function and role in kidney disease
Collagen formation, function and role in kidney disease
Highly abundant in mammals, collagens define the organization of tissues and participate in cell signalling. Most...
Kidney disease and reproductive health
Kidney disease and reproductive health
Understanding the relationship between reproductive health and kidney function is important to provide holistic care for p...
ECM remodelling by ADAMTS12 in fibrosis
Fibrosis results from the continuous deposition of extracellular matrix (ECM) by fibroblasts in response to injurious stim...
Treating AAV by targeting T cell responses
Treating AAV by targeting T cell responses
Glucocorticoids are currently used to induce remission in patients with antineutrophil cytoplasmic antibody glomerulonephr...
Bacteria caught in neutrophil and UMOD traps in urine
Bacteria caught in neutrophil and UMOD traps in urine
Several mechanisms prevent the ascent of uropathogenic bacteria from the bladder to the kidney, which can lead to pyelonep...
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