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Advancing gender equity to improve kidney care for women: a patient perspective
Women living with kidney disease are exposed to several sex and gender gaps in the clinical practice of standard hemodialy...
Collagen formation, function and role in kidney disease
Collagen formation, function and role in kidney disease
Highly abundant in mammals, collagens define the organization of tissues and participate in cell signalling. Most...
Kidney disease and reproductive health
Kidney disease and reproductive health
Understanding the relationship between reproductive health and kidney function is important to provide holistic care for p...
ECM remodelling by ADAMTS12 in fibrosis
Fibrosis results from the continuous deposition of extracellular matrix (ECM) by fibroblasts in response to injurious stim...
Treating AAV by targeting T cell responses
Treating AAV by targeting T cell responses
Glucocorticoids are currently used to induce remission in patients with antineutrophil cytoplasmic antibody glomerulonephr...
Bacteria caught in neutrophil and UMOD traps in urine
Bacteria caught in neutrophil and UMOD traps in urine
Several mechanisms prevent the ascent of uropathogenic bacteria from the bladder to the kidney, which can lead to pyelonep...
International expert consensus statement on the diagnosis and management of congenital nephrogenic diabetes insipidus (arginine vasopressin resistance)
International expert consensus statement on the diagnosis and management of congenital nephrogenic diabetes insipidus (arginine vasopressin resistance)
Congenital nephrogenic diabetes insipidus (NDI; also known as arginine vasopressin resistance) is a rare inherited disorde...
A guide to gene–disease relationships in nephrology
A guide to gene–disease relationships in nephrology
The use of next-generation sequencing technologies such as exome and genome sequencing in research and clinical care has t...
A guide to studying 3D genome structure and dynamics in the kidney
A guide to studying 3D genome structure and dynamics in the kidney
The human genome is tightly packed into the 3D environment of the cell nucleus. Rapidly evolving and sophisticated methods...
Multidisciplinary collaboration to improve neonatal kidney health
Multidisciplinary collaboration to improve neonatal kidney health
The Neonatal Kidney Collaborative is a multidisciplinary initiative that aims to improve neonatal kidney health. By unitin...
Renal nerves in physiology, pathophysiology and interoception
Renal nerves in physiology, pathophysiology and interoception
Sympathetic efferent renal nerves have key roles in the regulation of kidney function and blood pressure. Increased renal ...
New AAV vector targets glomerular endothelial cells
New AAV vector targets glomerular endothelial cells
Gene therapy is increasingly used in the clinic, but specific delivery to kidney cells remains an important obstacle to br...
Risk of kidney failure among patients with genetic kidney diseases
Monogenic alterations cause a variety of paediatric kidney diseases; however, insights into their association with clinica...
Spatial transcriptomics of acute kidney injury
Improved understanding of the cellular changes and interactions that occur in the kidney following injury may help to eluc...
Metabolism at the crossroads of inflammation and fibrosis in chronic kidney disease
Metabolism at the crossroads of inflammation and fibrosis in chronic kidney disease
Chronic kidney disease (CKD), defined as persistent (>3 months) kidney functional loss, has a growing prevalence (&...
Polygenic scores and their applications in kidney disease
Polygenic scores and their applications in kidney disease
Genome-wide association studies (GWAS) have uncovered thousands of risk variants that individually have small effects on t...
The pathogenesis of IgA nephropathy and implications for treatment
The pathogenesis of IgA nephropathy and implications for treatment
IgA nephropathy (IgAN) is a common form of primary glomerulonephritis and represents an important cause of chronic kidney ...
Reference-trial-informed design to explore treatment effects in trial-underrepresented subgroups
Randomized controlled trials (RCT) are often regarded as the ‘gold standard’ of clinical evidence. However, their strict e...
A novel mechanism of sodium and fluid retention in liver disease
A novel mechanism of sodium and fluid retention in liver disease
In patients with liver disease, sodium and fluid retention is often attributed to reduced effective blood volume, which st...
Towards an effective obstetric nephrology care: the Mansoura experience
Towards an effective obstetric nephrology care: the Mansoura experience
For women with kidney disease of childbearing age, kidney care should feature discussions of pregnancy, including informed...
Amino acid metabolism in kidney health and disease
Amino acid metabolism in kidney health and disease
Amino acids form peptides and proteins and are therefore considered the main building blocks of life. The kidney has an im...
NOX2 dampens TLR7 to protect the kidneys in SLE
NOX2 dampens TLR7 to protect the kidneys in SLE
Lupus nephritis (LN) is a common clinical complication in patients with systemic lupus erythematosus (SLE). A report by Ma...
Microglial activation in CKD-associated cognitive decline
Microglial activation in CKD-associated cognitive decline
Cognitive decline is common in patients with chronic kidney disease (CKD); however, the mechanisms linking these two condi...
The roles of hyaluronan in kidney development, physiology and disease
The roles of hyaluronan in kidney development, physiology and disease
The hyaluronan (HA) matrix in the tissue microenvironment is crucial for maintaining homeostasis by regulating inflammator...
Advances in uromodulin biology and potential clinical applications
Advances in uromodulin biology and potential clinical applications
Uromodulin (also known as Tamm–Horsfall protein) is a kidney-specific glycoprotein secreted bidirectionally into uri...
A focus on kidney ageing
Population ageing will exacerbate the burden of ageing-related diseases, including chronic kidney disease. Mitigating the ...
Improving the quality of pharmacoepidemiological studies using the target trial emulation framework
Improving the quality of pharmacoepidemiological studies using the target trial emulation framework
Randomized controlled trials (RCTs) remain the gold standard for assessing the efficacy or safety of a given medication or...
From improbable to possible: pregnancy with advanced chronic kidney disease
From improbable to possible: pregnancy with advanced chronic kidney disease
Reproductive health is an acknowledged right, yet women with chronic kidney disease (CKD) not only face reduced fertility ...
Lymphocytes and innate immune cells in acute kidney injury and repair
Lymphocytes and innate immune cells in acute kidney injury and repair
Acute kidney injury (AKI) is a common and serious disease entity that affects native kidneys and allografts but for which ...
CD38 — a new target in renal immune disease
CD38 — a new target in renal immune disease
Targeting of CD38 has been posited as a potential therapeutic avenue for the treatment of immune-mediated conditions. A ph...
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