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A UMOD variant with intermediate effects
Researchers have identified a p.Thr62Pro missense variant in UMOD that has intermediate biological effects. UMOD encodes u...
De-repression of Pkd1 or Pkd2 attenuates ADPKD
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Diagnosis and management of immune checkpoint inhibitor-associated acute kidney injury
Diagnosis and management of immune checkpoint inhibitor-associated acute kidney injury
Since their introduction into clinical practice a decade ago, immune checkpoint inhibitors (ICIs) have had an overwhelming...
Removal of small, asymptomatic kidney stones
A clinical trial reports that removal of small, asymptomatic kidney stones during surgery to remove ureteral or contralate...
Increased PD1 signalling in kidney ageing
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Author Correction: Impact of the COVID-19 pandemic on the kidney community: lessons learned and future directions
Department of Medicine, Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USADuvur...
Targeting perivascular S1P attenuates inflammation
Targeting perivascular S1P attenuates inflammation
Sphingosine 1-phosphate (S1P) contributes to inflammation, and drugs targeting its receptors are protective against kidney...
Nephrology and women’s health post-Roe v. Wade: we must do better
In the wake of the Supreme Court’s decision to abolish the right of American women to a pregnancy termination, the m...
Regulation of nephron progenitor cell lifespan and nephron endowment
Regulation of nephron progenitor cell lifespan and nephron endowment
Low nephron number — resulting, for example, from prematurity or developmental anomalies ...
Epidemiology and risk of cardiovascular disease in populations with chronic kidney disease
Epidemiology and risk of cardiovascular disease in populations with chronic kidney disease
Chronic kidney disease (CKD) is defined by a low glomerular filtration rate or high albuminuria, and affects 15–20% ...
Epidemiology of peritoneal dialysis outcomes
Epidemiology of peritoneal dialysis outcomes
Peritoneal dialysis (PD) is an important home-based treatment for kidney failure and accounts for 11% of all dialysis and ...
Targeting innate immunity-driven inflammation in CKD and cardiovascular disease
Targeting innate immunity-driven inflammation in CKD and cardiovascular disease
Mortality among patients with chronic kidney disease (CKD) is largely a consequence of cardiovascular disease (CVD) and is...
Cellular recovery after prolonged warm ischaemia
Cellular recovery after prolonged warm ischaemia
The donation potential of organs obtained following circulatory death is often limited as a consequence of ischaemic injur...
Impact of the COVID-19 pandemic on the kidney community: lessons learned and future directions
Impact of the COVID-19 pandemic on the kidney community: lessons learned and future directions
The coronavirus disease 2019 (COVID-19) pandemic has disproportionately affected patients with kidney disease, causing sig...
NCKs are essential to podocyte–GBM interactions
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In vivo slit diaphragm dynamics in Drosophila
Endocytosis is crucial role to the maintenance of the slit diaphragm. Now, an in vivo study of podocyte-like Drosophila ne...
Vaccination in patients with kidney failure: lessons from COVID-19
Vaccination in patients with kidney failure: lessons from COVID-19
Infection is the second leading cause of death in patients with chronic kidney disease (CKD). Adequate humoral (antibody) ...
Leveraging lysine metabolism for renoprotection
Altered lysine metabolism in the kidney has been implicated in disease processes. In a new study, tracking lysine metaboli...
YAP and TAZ regulate stromal cell development
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Electronic patient-reported outcomes in chronic kidney disease
Considerable research and investment have focused on the use of electronic patient-reported outcomes (ePROs) in nephrology...
MicroRNAs in kidney injury and disease
MicroRNAs in kidney injury and disease
MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression by degrading or repressing the translation of t...
A polygenic score predicts CKD across ancestries
A polygenic score predicts CKD across ancestries
Chronic kidney disease (CKD) is often well advanced before it is detected. Although polygenic scores may enable the early ...
Kidney disease as a medical complication of eating disorders
Kidney disease is an underappreciated medical complication of anorexia nervosa. Further research is needed to clarify the ...
Cellular senescence: the good, the bad and the unknown
Cellular senescence: the good, the bad and the unknown
Cellular senescence is a ubiquitous process with roles in tissue remodelling, including wound repair and embryogenesis. Ho...
Pervasive kidney health inequities for Māori require multi-level attention
Indigenous Māori experience inequitably high rates of kidney failure and lower rates of kidney transplant, pre-emptiv...
Restrictive fluid therapy and high-dose vitamin C in sepsis
Two recent randomized trials provide evidence to guide the management of sepsis. The CLASSIC trial reports that restrictiv...
A pathway of osmotic stress-induced necroptosis
A pathway of osmotic stress-induced necroptosis
Necroptosis is a form of regulated necrosis in which RIPK3 is activated by binding to RIP homotypic interaction motif (RHI...
Quantifying access to transplantation
Disparities in access to kidney transplantation are known to exist. Using data from the United States Renal Data System an...
Activation and regulation of alloreactive T cell immunity in solid organ transplantation
Activation and regulation of alloreactive T cell immunity in solid organ transplantation
Transplantation is the only curative treatment for patients with kidney failure but it poses unique immunological challeng...
Unmet care needs of minority groups on dialysis
Many patients on dialysis report unmet existential and supportive care needs. New findings from a survey of patients in tw...