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Sperm DNA methylation alterations from cannabis extract exposure are evident in offspring
Sperm DNA methylation alterations from cannabis extract exposure are evident in offspring
Cannabis legalization is expanding and men are the predominant users. We have limited knowledge about how cannabis impacts...
PDS5A and PDS5B differentially affect gene expression without altering cohesin localization across the genome
PDS5A and PDS5B differentially affect gene expression without altering cohesin localization across the genome
Cohesin is an important structural regulator of the genome, regulating both three-dimensional genome organization and gene...
An epigenetically inherited UV hyper-resistance phenotype in Saccharomyces cerevisiae
An epigenetically inherited UV hyper-resistance phenotype in Saccharomyces cerevisiae
Epigenetics refers to inheritable phenotypic changes that occur in the absence of genetic alteration. Such adaptations can...
Placental imprinting of SLC22A3 in the IGF2R imprinted domain is conserved in therian mammals
Placental imprinting of SLC22A3 in the IGF2R imprinted domain is conserved in therian mammals
The eutherian IGF2R imprinted domain is regulated by an antisense long non-coding RNA, Airn, which is expressed from a dif...
The mismatch-repair proteins MSH2 and MSH6 interact with the imprinting control regions through the ZFP57-KAP1 complex
The mismatch-repair proteins MSH2 and MSH6 interact with the imprinting control regions through the ZFP57-KAP1 complex
Imprinting Control Regions (ICRs) are CpG-rich sequences acquiring differential methylation in the female and male germlin...
Maternal SMCHD1 controls both imprinted Xist expression and imprinted X chromosome inactivation
Maternal SMCHD1 controls both imprinted Xist expression and imprinted X chromosome inactivation
Embryonic development is dependent on the maternal supply of proteins through the oocyte, including factors setting up the...
3DFAACTS-SNP: using regulatory T cell-specific epigenomics data to uncover candidate mechanisms of type 1 diabetes (T1D) risk
3DFAACTS-SNP: using regulatory T cell-specific epigenomics data to uncover candidate mechanisms of type 1 diabetes (T1D) risk
Genome-wide association studies (GWAS) have enabled the discovery of single nucleotide polymorphisms (SNPs) that are signi...
Multiple epigenetic factors co-localize with HMGN proteins in A-compartment chromatin
Multiple epigenetic factors co-localize with HMGN proteins in A-compartment chromatin
Nucleosomal binding proteins, HMGN, is a family of chromatin architectural proteins that are expressed in all vertebrate n...
Viral histones: pickpocket’s prize or primordial progenitor?
Viral histones: pickpocket’s prize or primordial progenitor?
The common histones H2A, H2B, H3, and H4 are the characteristic components of eukaryotic nucleosomes, which function to wr...
Structural comparisons reveal diverse binding modes between nucleosome assembly proteins and histones
Structural comparisons reveal diverse binding modes between nucleosome assembly proteins and histones
Nucleosome assembly proteins (NAPs) are histone chaperones that play a central role in facilitating chromatin assembly/dis...
Heterosis of growth trait regulated by DNA methylation and miRNA in allotriploid fish
Heterosis of growth trait regulated by DNA methylation and miRNA in allotriploid fish
Heterosis of growth traits in allotriploid fish has benefited the production of aquaculture for many years, yet its geneti...
Structural and functional specificity of H3K36 methylation
Structural and functional specificity of H3K36 methylation
The methylation of histone H3 at lysine 36 (H3K36me) is essential for maintaining genomic stability. Indeed, this methylat...
Histone H3.3 K27M chromatin functions implicate a network of neurodevelopmental factors including ASCL1 and NEUROD1 in DIPG
Histone H3.3 K27M chromatin functions implicate a network of neurodevelopmental factors including ASCL1 and NEUROD1 in DIPG
The histone variant H3.3 K27M mutation is a defining characteristic of diffuse intrinsic pontine glioma (DIPG)/diffuse mid...
DNA methylation may affect beef tenderness through signal transduction in Bos indicus
DNA methylation may affect beef tenderness through signal transduction in Bos indicus
Beef tenderness is a complex trait of economic importance for the beef industry. Understanding the epigenetic mechanisms u...
Mouse Chd4-NURD is required for neonatal spermatogonia survival and normal gonad development
Mouse Chd4-NURD is required for neonatal spermatogonia survival and normal gonad development
Testis development and sustained germ cell production in adults rely on the establishment and maintenance of spermatogonia...
Functions of HP1 proteins in transcriptional regulation
Functions of HP1 proteins in transcriptional regulation
In eukaryotes, DNA is packaged into chromatin, which presents significant barriers to transcription. Non-histone chromatin...
Pioneer transcription factors are associated with the modulation of DNA methylation patterns across cancers
Pioneer transcription factors are associated with the modulation of DNA methylation patterns across cancers
Methylation of cytosines on DNA is a prominent modification associated with gene expression regulation. Aberrant DNA methy...
Mitochondrial supplementation of Sus scrofa metaphase II oocytes alters DNA methylation and gene expression profiles of blastocysts
Mitochondrial supplementation of Sus scrofa metaphase II oocytes alters DNA methylation and gene expression profiles of blastocysts
Mitochondrial DNA (mtDNA) copy number in oocytes correlates with oocyte quality and fertilisation outcome. The introductio...
TET-mediated DNA hydroxymethylation is negatively influenced by the PARP-dependent PARylation
TET-mediated DNA hydroxymethylation is negatively influenced by the PARP-dependent PARylation
Poly(ADP-ribosyl)ation (PARylation), a posttranslational modification introduced by PARP-1 and PARP-2, has first been impl...
Pan-cancer predictions of transcription factors mediating aberrant DNA methylation
Pan-cancer predictions of transcription factors mediating aberrant DNA methylation
Aberrant DNA methylation is a hallmark of cancer cells. However, the mechanisms underlying changes in DNA methylation rema...
Deconvolution of the epigenetic age discloses distinct inter-personal variability in epigenetic aging patterns
Deconvolution of the epigenetic age discloses distinct inter-personal variability in epigenetic aging patterns
The epigenetic age can now be extrapolated from one of several epigenetic clocks, which are based on age-related changes i...
Changes in DNA methylation hallmark alterations in chromatin accessibility and gene expression for eye lens differentiation
Changes in DNA methylation hallmark alterations in chromatin accessibility and gene expression for eye lens differentiation
Methylation at cytosines (mCG) is a well-known regulator of gene expression, but its requirements for cellular differentia...
Evolutionary adaptation of the Polycomb repressive complex 2
Evolutionary adaptation of the Polycomb repressive complex 2
The Polycomb repressive complex 2 (PRC2) is an essential chromatin regulatory complex involved in repressing the transcrip...
Multiple distinct domains of human XIST are required to coordinate gene silencing and subsequent heterochromatin formation
Multiple distinct domains of human XIST are required to coordinate gene silencing and subsequent heterochromatin formation
Mammalian dosage compensation is achieved by the inactivation of one X chromosome in XX individuals. In eutheria this proc...
The regional sequestration of heterochromatin structural proteins is critical to form and maintain silent chromatin
The regional sequestration of heterochromatin structural proteins is critical to form and maintain silent chromatin
Budding yeast Saccharomyces cerevisiae and fission yeast Schizosaccharomyces pombe are good models for heterochromatin stu...
Making sense of the linear genome, gene function and TADs
Making sense of the linear genome, gene function and TADs
Topologically associating domains (TADs) are thought to act as functional units in the genome. TADs co-localise genes and ...
Effects of paternal exposure to cigarette smoke on sperm DNA methylation and long-term metabolic syndrome in offspring
Effects of paternal exposure to cigarette smoke on sperm DNA methylation and long-term metabolic syndrome in offspring
Although paternal exposure to cigarette smoke may contribute to obesity and metabolic syndrome in offspring, the underlyin...