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Premature ovarian insufficiency is associated with global alterations in the regulatory landscape and gene expression in balanced X-autosome translocations
Premature ovarian insufficiency is associated with global alterations in the regulatory landscape and gene expression in balanced X-autosome translocations
Patients with balanced X-autosome translocations and premature ovarian insufficiency (POI) constitute an interesting parad...
The MMP-2 histone H3 N-terminal tail protease is selectively targeted to the transcription start sites of active genes
The MMP-2 histone H3 N-terminal tail protease is selectively targeted to the transcription start sites of active genes
Proteolysis of the histone H3 N-terminal tail (H3NT) is an evolutionarily conserved epigenomic feature of nearly all eukar...
Loss of CpG island immunity to DNA methylation induced by mutation
Loss of CpG island immunity to DNA methylation induced by mutation
The inheritance of acquired traits in mammals is a highly controversial topic in biology. Recently, Takahashi et al. (Cell...
The pattern of histone H3 epigenetic posttranslational modifications is regulated by the VRK1 chromatin kinase
The pattern of histone H3 epigenetic posttranslational modifications is regulated by the VRK1 chromatin kinase
Dynamic chromatin remodeling is associated with changes in the epigenetic pattern of histone acetylations and methylations...
Caf1 regulates the histone methyltransferase activity of Ash1 by sensing unmodified histone H3
Caf1 regulates the histone methyltransferase activity of Ash1 by sensing unmodified histone H3
Histone modifications are one of the many key mechanisms that regulate gene expression. Ash1 is a histone H3K36 methyltran...
Epigenetic modifier alpha-ketoglutarate modulates aberrant gene body methylation and hydroxymethylation marks in diabetic heart
Epigenetic modifier alpha-ketoglutarate modulates aberrant gene body methylation and hydroxymethylation marks in diabetic heart
Diabetic cardiomyopathy (DCM) is a leading cause of death in diabetic patients. Hyperglycemic myocardial microenvironment ...
An optimized approach for multiplexing single-nuclear ATAC-seq using oligonucleotide-conjugated antibodies
An optimized approach for multiplexing single-nuclear ATAC-seq using oligonucleotide-conjugated antibodies
Single-cell technologies to analyze transcription and chromatin structure have been widely used in many research areas to ...
Partial erosion on under-methylated regions and chromatin reprogramming contribute to oncogene activation in IDH mutant gliomas
Partial erosion on under-methylated regions and chromatin reprogramming contribute to oncogene activation in IDH mutant gliomas
IDH1/2 hotspot mutations are well known to drive oncogenic mutations in gliomas and are well-defined in the WHO 2021 class...
Ovulatory signal-triggered chromatin remodeling in ovarian granulosa cells by HDAC2 phosphorylation activation-mediated histone deacetylation
Ovulatory signal-triggered chromatin remodeling in ovarian granulosa cells by HDAC2 phosphorylation activation-mediated histone deacetylation
Epigenetic reprogramming is involved in luteinizing hormone (LH)-induced ovulation; however, the underlying mechanisms are...
Multilevel interrogation of H3.3 reveals a primordial role in transcription regulation
Multilevel interrogation of H3.3 reveals a primordial role in transcription regulation
Eukaryotic cells can rapidly adjust their transcriptional profile in response to molecular needs. Such dynamic regulation ...
PCGF6/MAX/KDM5D facilitates MAZ/CDK4 axis expression and pRCC progression by hypomethylation of the DNA promoter
PCGF6/MAX/KDM5D facilitates MAZ/CDK4 axis expression and pRCC progression by hypomethylation of the DNA promoter
Polycomb group RING finger protein 6 (PCGF6) plays an important role as a regulator of transcription in a variety of cellu...
The transgenic IG-DMR sequence of the mouse Dlk1-Dio3 domain acquired imprinted DNA methylation during the post-fertilization period
The transgenic IG-DMR sequence of the mouse Dlk1-Dio3 domain acquired imprinted DNA methylation during the post-fertilization period
Allele-specific methylation of the imprinting control region (ICR) is the molecular basis for the genomic imprinting pheno...
Proximity labeling reveals a new in vivo network of interactors for the histone demethylase KDM5
Proximity labeling reveals a new in vivo network of interactors for the histone demethylase KDM5
KDM5 family proteins are multi-domain regulators of transcription that when dysregulated contribute to cancer and intellec...
The SAGA histone acetyltransferase module targets SMC5/6 to specific genes
The SAGA histone acetyltransferase module targets SMC5/6 to specific genes
Structural Maintenance of Chromosomes (SMC) complexes are molecular machines driving chromatin organization at higher leve...
The impact of spatial correlation on methylation entropy with application to mouse brain methylome
The impact of spatial correlation on methylation entropy with application to mouse brain methylome
With the advance of bisulfite sequencing technologies, massive amount of methylation data have been generated, which provi...
Phthalates impact on the epigenetic factors contributed specifically by the father at fertilization
Phthalates impact on the epigenetic factors contributed specifically by the father at fertilization
Preconception exposure to phthalates such as the anti-androgenic dibutyl-phthalate (DBP) impacts both male and female repr...
Dynamic changes in whole genome DNA methylation, chromatin and gene expression during mouse lens differentiation
Dynamic changes in whole genome DNA methylation, chromatin and gene expression during mouse lens differentiation
Cellular differentiation is marked by temporally and spatially coordinated gene expression regulated at multiple levels. D...
ATAC-seq and RNA-seq analysis unravel the mechanism of sex differentiation and infertility in sex reversal chicken
ATAC-seq and RNA-seq analysis unravel the mechanism of sex differentiation and infertility in sex reversal chicken
Sex determination and differentiation are complex and delicate processes. In female chickens, the process of sex different...
Who’s afraid of the X? Incorporating the X and Y chromosomes into the analysis of DNA methylation array data
Who’s afraid of the X? Incorporating the X and Y chromosomes into the analysis of DNA methylation array data
Many human disease phenotypes manifest differently by sex, making the development of methods for incorporating X and Y-chr...
Characterizing chromatin interactions of regulatory elements and nucleosome positions, using Hi-C, Micro-C, and promoter capture Micro-C
Characterizing chromatin interactions of regulatory elements and nucleosome positions, using Hi-C, Micro-C, and promoter capture Micro-C
Regulatory elements such as promoters, enhancers, and insulators interact each other to mediate molecular processes. To ca...
Efficient generation of epigenetic disease model mice by epigenome editing using the piggyBac transposon system
Efficient generation of epigenetic disease model mice by epigenome editing using the piggyBac transposon system
Epigenome-edited animal models enable direct demonstration of disease causing epigenetic mutations. Transgenic (TG) mice s...
Shaking up the silence: consequences of HMGN1 antagonizing PRC2 in the Down syndrome brain
Shaking up the silence: consequences of HMGN1 antagonizing PRC2 in the Down syndrome brain
Intellectual disability is a well-known hallmark of Down Syndrome (DS) that results from the triplication of the critical ...
Manipulating chromatin architecture in C. elegans
Manipulating chromatin architecture in C. elegans
Nucleosome-mediated chromatin compaction has a direct effect on the accessibility of trans-acting activators and repressor...
Contribution of variant subunits and associated factors to genome-wide distribution and dynamics of cohesin
Contribution of variant subunits and associated factors to genome-wide distribution and dynamics of cohesin
The cohesin complex organizes the genome-forming dynamic chromatin loops that impact on all DNA-mediated processes. There ...
De novo methylation of histone H3K23 by the methyltransferases EHMT1/GLP and EHMT2/G9a
De novo methylation of histone H3K23 by the methyltransferases EHMT1/GLP and EHMT2/G9a
Epigenetic modifications to histone proteins serve an important role in regulating permissive and repressive chromatin sta...
Investigation of reversible histone acetylation and dynamics in gene expression regulation using 3D liver spheroid model
Investigation of reversible histone acetylation and dynamics in gene expression regulation using 3D liver spheroid model
Three-dimensional (3D) cell culture has emerged as an alternative approach to 2D flat culture to model more accurately the...
A standardized nomenclature for mammalian histone genes
A standardized nomenclature for mammalian histone genes
Histones have a long history of research in a wide range of species, leaving a legacy of complex nomenclature in the liter...
Sperm DNA methylation alterations from cannabis extract exposure are evident in offspring
Sperm DNA methylation alterations from cannabis extract exposure are evident in offspring
Cannabis legalization is expanding and men are the predominant users. We have limited knowledge about how cannabis impacts...
PDS5A and PDS5B differentially affect gene expression without altering cohesin localization across the genome
PDS5A and PDS5B differentially affect gene expression without altering cohesin localization across the genome
Cohesin is an important structural regulator of the genome, regulating both three-dimensional genome organization and gene...
An epigenetically inherited UV hyper-resistance phenotype in Saccharomyces cerevisiae
An epigenetically inherited UV hyper-resistance phenotype in Saccharomyces cerevisiae
Epigenetics refers to inheritable phenotypic changes that occur in the absence of genetic alteration. Such adaptations can...
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