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Transcriptional silencing in Saccharomyces cerevisiae: known unknowns
Transcriptional silencing in Saccharomyces cerevisiae: known unknowns
Transcriptional silencing in Saccharomyces cerevisiae is a persistent and highly stable form of gene repression. It involv...
The role of hexokinases in epigenetic regulation: altered hexokinase expression and chromatin stability in yeast
The role of hexokinases in epigenetic regulation: altered hexokinase expression and chromatin stability in yeast
Human hexokinase 2 (HK2) plays an important role in regulating Warburg effect, which metabolizes glucose to lactate acid e...
Transcriptional regulation mechanism of PARP1 and its application in disease treatment
Transcriptional regulation mechanism of PARP1 and its application in disease treatment
Poly (ADP-ribose) polymerase 1 (PARP1) is a multifunctional nuclear enzyme that catalyzes poly-ADP ribosylation in eukaryo...
DNA methylation correlates of chronological age in diverse human tissue types
DNA methylation correlates of chronological age in diverse human tissue types
While the association of chronological age with DNA methylation (DNAm) in whole blood has been extensively studied, the ti...
Long-term exposure to diesel exhaust particles induces concordant changes in DNA methylation and transcriptome in human adenocarcinoma alveolar basal epithelial cells
Long-term exposure to diesel exhaust particles induces concordant changes in DNA methylation and transcriptome in human adenocarcinoma alveolar basal epithelial cells
Diesel exhaust particles (DEP), which contain hazardous compounds, are emitted during the combustion of diesel. As approxi...
The role of ribosomal DNA methylation in embryonic development, aging and diseases
The role of ribosomal DNA methylation in embryonic development, aging and diseases
The ribosomal DNA (rDNA) constitutes a remarkably conserved DNA sequence within species, located in the area of the nucleo...
CUT&Tag applied to zebrafish adult tail fins reveals a return of embryonic H3K4me3 patterns during regeneration
CUT&Tag applied to zebrafish adult tail fins reveals a return of embryonic H3K4me3 patterns during regeneration
Regenerative potential is governed by a complex process of transcriptional reprogramming, involving chromatin reorganizati...
CREdb: A comprehensive database of Cis-Regulatory Elements and their activity in human cells and tissues
CREdb: A comprehensive database of Cis-Regulatory Elements and their activity in human cells and tissues
Cis-regulatory elements (CREs) play a pivotal role in gene expression regulation, allowing cells to serve diverse function...
Imprinted DNA methylation of the H19 ICR is established and maintained in vivo in the absence of Kaiso
Imprinted DNA methylation of the H19 ICR is established and maintained in vivo in the absence of Kaiso
Paternal allele-specific DNA methylation of the imprinting control region (H19 ICR) controls genomic imprinting at the Igf...
Native and tagged CENP-A histones are functionally inequivalent
Native and tagged CENP-A histones are functionally inequivalent
Over the past several decades, the use of biochemical and fluorescent tags has elucidated mechanistic and cytological proc...
From compartments to loops: understanding the unique chromatin organization in neuronal cells
From compartments to loops: understanding the unique chromatin organization in neuronal cells
The three-dimensional organization of the genome plays a central role in the regulation of cellular functions, particularl...
Su(Hw) interacts with Combgap to establish long-range chromatin contacts
Su(Hw) interacts with Combgap to establish long-range chromatin contacts
Insulator-binding proteins (IBPs) play a critical role in genome architecture by forming and maintaining contact domains. ...
Chromatin profiling and state predictions reveal insights into epigenetic regulation during early porcine development
Chromatin profiling and state predictions reveal insights into epigenetic regulation during early porcine development
Given their physiological similarities to humans, pigs are increasingly used as model organisms in human-oriented biomedic...
Roles of post-translational modifications of UHRF1 in cancer
Roles of post-translational modifications of UHRF1 in cancer
UHRF1 as a member of RING-finger type E3 ubiquitin ligases family, is an epigenetic regulator with five structural domains...
Prenatal nicotine exposure leads to epigenetic alterations in peripheral nervous system signaling genes in the testis of the rat
Prenatal nicotine exposure leads to epigenetic alterations in peripheral nervous system signaling genes in the testis of the rat
Prenatal nicotine exposure (PNE) has been documented to cause numerous deleterious effects on fetal development. However, ...
The probability of chromatin to be at the nuclear lamina has no systematic effect on its transcription level in fruit flies
The probability of chromatin to be at the nuclear lamina has no systematic effect on its transcription level in fruit flies
Multiple studies have demonstrated a negative correlation between gene expression and positioning of genes at the nuclear ...
Reinforcement of repressive marks in the chicken primordial germ cell epigenetic signature: divergence from basal state resetting in mammals
Reinforcement of repressive marks in the chicken primordial germ cell epigenetic signature: divergence from basal state resetting in mammals
In mammals, primordial germ cells (PGCs), the embryonic precursors of the germline, arise from embryonic or extra-embryoni...
Histone proteoform analysis reveals epigenetic changes in adult mouse brown adipose tissue in response to cold stress
Histone proteoform analysis reveals epigenetic changes in adult mouse brown adipose tissue in response to cold stress
Regulation of the thermogenic response by brown adipose tissue (BAT) is an important component of energy homeostasis with ...
Analysis of long-range chromatin contacts, compartments and looping between mouse embryonic stem cells, lens epithelium and lens fibers
Analysis of long-range chromatin contacts, compartments and looping between mouse embryonic stem cells, lens epithelium and lens fibers
Nuclear organization of interphase chromosomes involves individual chromosome territories, “open” and “c...
The N-terminal dimerization domains of human and Drosophila CTCF have similar functionality
The N-terminal dimerization domains of human and Drosophila CTCF have similar functionality
CTCF is highly likely to be the ancestor of proteins that contain large clusters of C2H2 zinc finger domains, and its cons...
Transcriptionally active chromatin loops contain both ‘active’ and ‘inactive’ histone modifications that exhibit exclusivity at the level of nucleosome clusters
Transcriptionally active chromatin loops contain both ‘active’ and ‘inactive’ histone modifications that exhibit exclusivity at the level of nucleosome clusters
Chromatin state is thought to impart regulatory function to the underlying DNA sequence. This can be established through h...
Incorporation of the histone variant H2A.Z counteracts gene silencing mediated by H3K27 trimethylation in Fusarium fujikuroi
Incorporation of the histone variant H2A.Z counteracts gene silencing mediated by H3K27 trimethylation in Fusarium fujikuroi
Fusarium fujikuroi is a pathogen of rice causing diverse disease symptoms such as ‘bakanae’ or stunting, most ...
TP63–TRIM29 axis regulates enhancer methylation and chromosomal instability in prostate cancer
TP63–TRIM29 axis regulates enhancer methylation and chromosomal instability in prostate cancer
Prostate adenocarcinoma (PRAD) is the second leading cause of cancer-related deaths in men. High variability in DNA methyl...
Intrafamily heterooligomerization as an emerging mechanism of methyltransferase regulation
Intrafamily heterooligomerization as an emerging mechanism of methyltransferase regulation
Protein and nucleic acid methylation are important biochemical modifications. In addition to their well-established roles ...
Research progress of SWI/SNF complex in breast cancer
Research progress of SWI/SNF complex in breast cancer
In the past decade, numerous epigenetic mechanisms have been discovered to be associated with cancer. The mammalian SWI/SN...
A low-input high resolution sequential chromatin immunoprecipitation method captures genome-wide dynamics of bivalent chromatin
A low-input high resolution sequential chromatin immunoprecipitation method captures genome-wide dynamics of bivalent chromatin
Bivalent chromatin is an exemplar of epigenetic plasticity. This co-occurrence of active-associated H3K4me3 and inactive-a...
Role of sex in immune response and epigenetic mechanisms
Role of sex in immune response and epigenetic mechanisms
The functioning of the human immune system is highly dependent on the sex of the individual, which comes by virtue of sex ...
Chromatin accessibility and cell cycle progression are controlled by the HDAC-associated Sin3B protein in murine hematopoietic stem cells
Chromatin accessibility and cell cycle progression are controlled by the HDAC-associated Sin3B protein in murine hematopoietic stem cells
Blood homeostasis requires the daily production of millions of terminally differentiated effector cells that all originate...
Folate deficiency reduced aberrant level of DOT1L-mediated histone H3K79 methylation causes disruptive SHH gene expression involved in neural tube defects
Folate deficiency reduced aberrant level of DOT1L-mediated histone H3K79 methylation causes disruptive SHH gene expression involved in neural tube defects
Neural tube defects (NTDs) are one of the most severe congenital abnormalities characterized by failures of the neural tub...
O-GlcNAcylation: the sweet side of epigenetics
O-GlcNAcylation: the sweet side of epigenetics
Histones display a wide variety of post-translational modifications, including acetylation, methylation, and phosphorylati...
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