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FOSL1 is a key regulator of a super-enhancer driving TCOF1 expression in triple-negative breast cancer
FOSL1 is a key regulator of a super-enhancer driving TCOF1 expression in triple-negative breast cancer
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with an unmet clinical need, but its epigen...
Chromatin structure and 3D architecture define the differential functions of PU.1 regulatory elements in blood cell lineages
Chromatin structure and 3D architecture define the differential functions of PU.1 regulatory elements in blood cell lineages
The precise spatiotemporal expression of the hematopoietic ETS transcription factor PU.1, a key determinant of hematopoiet...
H3.3K122A results in a neomorphic phenotype in mouse embryonic stem cells
H3.3K122A results in a neomorphic phenotype in mouse embryonic stem cells
Canonical histone H3 and histone variant H3.3 are posttranslationally modified with the genomic distribution of these mark...
Epigenetic frontiers: miRNAs, long non-coding RNAs and nanomaterials are pioneering to cancer therapy
Epigenetic frontiers: miRNAs, long non-coding RNAs and nanomaterials are pioneering to cancer therapy
Cancer has arisen from both genetic mutations and epigenetic changes, making epigenetics a crucial area of research for in...
Methylation patterns at the adjacent CpG sites within enhancers are a part of cell identity
Methylation patterns at the adjacent CpG sites within enhancers are a part of cell identity
It is generally accepted that methylation status of CpG sites spaced up to 50 bp apart is correlated, and accumul...
PRKACB is a novel imprinted gene in marsupials
PRKACB is a novel imprinted gene in marsupials
Genomic imprinting results in parent-of-origin-specific gene expression and, among vertebrates, is found only in therian m...
Transcriptional silencing in Saccharomyces cerevisiae: known unknowns
Transcriptional silencing in Saccharomyces cerevisiae: known unknowns
Transcriptional silencing in Saccharomyces cerevisiae is a persistent and highly stable form of gene repression. It involv...
The role of hexokinases in epigenetic regulation: altered hexokinase expression and chromatin stability in yeast
The role of hexokinases in epigenetic regulation: altered hexokinase expression and chromatin stability in yeast
Human hexokinase 2 (HK2) plays an important role in regulating Warburg effect, which metabolizes glucose to lactate acid e...
Transcriptional regulation mechanism of PARP1 and its application in disease treatment
Transcriptional regulation mechanism of PARP1 and its application in disease treatment
Poly (ADP-ribose) polymerase 1 (PARP1) is a multifunctional nuclear enzyme that catalyzes poly-ADP ribosylation in eukaryo...
DNA methylation correlates of chronological age in diverse human tissue types
DNA methylation correlates of chronological age in diverse human tissue types
While the association of chronological age with DNA methylation (DNAm) in whole blood has been extensively studied, the ti...
Long-term exposure to diesel exhaust particles induces concordant changes in DNA methylation and transcriptome in human adenocarcinoma alveolar basal epithelial cells
Long-term exposure to diesel exhaust particles induces concordant changes in DNA methylation and transcriptome in human adenocarcinoma alveolar basal epithelial cells
Diesel exhaust particles (DEP), which contain hazardous compounds, are emitted during the combustion of diesel. As approxi...
The role of ribosomal DNA methylation in embryonic development, aging and diseases
The role of ribosomal DNA methylation in embryonic development, aging and diseases
The ribosomal DNA (rDNA) constitutes a remarkably conserved DNA sequence within species, located in the area of the nucleo...
CUT&Tag applied to zebrafish adult tail fins reveals a return of embryonic H3K4me3 patterns during regeneration
CUT&Tag applied to zebrafish adult tail fins reveals a return of embryonic H3K4me3 patterns during regeneration
Regenerative potential is governed by a complex process of transcriptional reprogramming, involving chromatin reorganizati...
CREdb: A comprehensive database of Cis-Regulatory Elements and their activity in human cells and tissues
CREdb: A comprehensive database of Cis-Regulatory Elements and their activity in human cells and tissues
Cis-regulatory elements (CREs) play a pivotal role in gene expression regulation, allowing cells to serve diverse function...
Imprinted DNA methylation of the H19 ICR is established and maintained in vivo in the absence of Kaiso
Imprinted DNA methylation of the H19 ICR is established and maintained in vivo in the absence of Kaiso
Paternal allele-specific DNA methylation of the imprinting control region (H19 ICR) controls genomic imprinting at the Igf...
Native and tagged CENP-A histones are functionally inequivalent
Native and tagged CENP-A histones are functionally inequivalent
Over the past several decades, the use of biochemical and fluorescent tags has elucidated mechanistic and cytological proc...
From compartments to loops: understanding the unique chromatin organization in neuronal cells
From compartments to loops: understanding the unique chromatin organization in neuronal cells
The three-dimensional organization of the genome plays a central role in the regulation of cellular functions, particularl...
Su(Hw) interacts with Combgap to establish long-range chromatin contacts
Su(Hw) interacts with Combgap to establish long-range chromatin contacts
Insulator-binding proteins (IBPs) play a critical role in genome architecture by forming and maintaining contact domains. ...
Chromatin profiling and state predictions reveal insights into epigenetic regulation during early porcine development
Chromatin profiling and state predictions reveal insights into epigenetic regulation during early porcine development
Given their physiological similarities to humans, pigs are increasingly used as model organisms in human-oriented biomedic...
Roles of post-translational modifications of UHRF1 in cancer
Roles of post-translational modifications of UHRF1 in cancer
UHRF1 as a member of RING-finger type E3 ubiquitin ligases family, is an epigenetic regulator with five structural domains...
Prenatal nicotine exposure leads to epigenetic alterations in peripheral nervous system signaling genes in the testis of the rat
Prenatal nicotine exposure leads to epigenetic alterations in peripheral nervous system signaling genes in the testis of the rat
Prenatal nicotine exposure (PNE) has been documented to cause numerous deleterious effects on fetal development. However, ...
The probability of chromatin to be at the nuclear lamina has no systematic effect on its transcription level in fruit flies
The probability of chromatin to be at the nuclear lamina has no systematic effect on its transcription level in fruit flies
Multiple studies have demonstrated a negative correlation between gene expression and positioning of genes at the nuclear ...
Reinforcement of repressive marks in the chicken primordial germ cell epigenetic signature: divergence from basal state resetting in mammals
Reinforcement of repressive marks in the chicken primordial germ cell epigenetic signature: divergence from basal state resetting in mammals
In mammals, primordial germ cells (PGCs), the embryonic precursors of the germline, arise from embryonic or extra-embryoni...
Histone proteoform analysis reveals epigenetic changes in adult mouse brown adipose tissue in response to cold stress
Histone proteoform analysis reveals epigenetic changes in adult mouse brown adipose tissue in response to cold stress
Regulation of the thermogenic response by brown adipose tissue (BAT) is an important component of energy homeostasis with ...
Analysis of long-range chromatin contacts, compartments and looping between mouse embryonic stem cells, lens epithelium and lens fibers
Analysis of long-range chromatin contacts, compartments and looping between mouse embryonic stem cells, lens epithelium and lens fibers
Nuclear organization of interphase chromosomes involves individual chromosome territories, “open” and “c...
The N-terminal dimerization domains of human and Drosophila CTCF have similar functionality
The N-terminal dimerization domains of human and Drosophila CTCF have similar functionality
CTCF is highly likely to be the ancestor of proteins that contain large clusters of C2H2 zinc finger domains, and its cons...
Transcriptionally active chromatin loops contain both ‘active’ and ‘inactive’ histone modifications that exhibit exclusivity at the level of nucleosome clusters
Transcriptionally active chromatin loops contain both ‘active’ and ‘inactive’ histone modifications that exhibit exclusivity at the level of nucleosome clusters
Chromatin state is thought to impart regulatory function to the underlying DNA sequence. This can be established through h...
Incorporation of the histone variant H2A.Z counteracts gene silencing mediated by H3K27 trimethylation in Fusarium fujikuroi
Incorporation of the histone variant H2A.Z counteracts gene silencing mediated by H3K27 trimethylation in Fusarium fujikuroi
Fusarium fujikuroi is a pathogen of rice causing diverse disease symptoms such as ‘bakanae’ or stunting, most ...
TP63–TRIM29 axis regulates enhancer methylation and chromosomal instability in prostate cancer
TP63–TRIM29 axis regulates enhancer methylation and chromosomal instability in prostate cancer
Prostate adenocarcinoma (PRAD) is the second leading cause of cancer-related deaths in men. High variability in DNA methyl...
Intrafamily heterooligomerization as an emerging mechanism of methyltransferase regulation
Intrafamily heterooligomerization as an emerging mechanism of methyltransferase regulation
Protein and nucleic acid methylation are important biochemical modifications. In addition to their well-established roles ...
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