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Epigene functional diversity: isoform usage, disordered domain content, and variable binding partners
Epigene functional diversity: isoform usage, disordered domain content, and variable binding partners
Epigenes are defined as proteins that perform post-translational modification of histones or DNA, reading of post-translat...
Assessment of relationships between epigenetic age acceleration and multiple sclerosis: a bidirectional mendelian randomization study
Assessment of relationships between epigenetic age acceleration and multiple sclerosis: a bidirectional mendelian randomization study
The DNA methylation-based epigenetic clocks are increasingly recognized for their precision in predicting aging and its he...
Comprehensive analysis of H3K27me3 LOCKs under different DNA methylation contexts reveal epigenetic redistribution in tumorigenesis
Comprehensive analysis of H3K27me3 LOCKs under different DNA methylation contexts reveal epigenetic redistribution in tumorigenesis
Histone modification H3K27me3 plays a critical role in normal development and is associated with various diseases, includi...
Acquired sperm hypomethylation by gestational arsenic exposure is re-established in both the paternal and maternal genomes of post-epigenetic reprogramming embryos
Acquired sperm hypomethylation by gestational arsenic exposure is re-established in both the paternal and maternal genomes of post-epigenetic reprogramming embryos
DNA methylation plays a crucial role in mammalian development. While methylome changes acquired in the parental genomes ar...
Crosstalk between non-coding RNAs and programmed cell death in colorectal cancer: implications for targeted therapy
Crosstalk between non-coding RNAs and programmed cell death in colorectal cancer: implications for targeted therapy
Colorectal cancer (CRC) remains one of the most common causes of cancer-related mortality worldwide. Its progression is in...
Tissue-specific roles of de novo DNA methyltransferases
Tissue-specific roles of de novo DNA methyltransferases
DNA methylation, catalyzed by DNA methyltransferases (DNMT), plays pivotal role in regulating embryonic development, gene ...
H3K9 post-translational modifications regulate epiblast/primitive endoderm specification in rabbit blastocysts
H3K9 post-translational modifications regulate epiblast/primitive endoderm specification in rabbit blastocysts
Post-translational modifications of histone H3 on lysine 9, specifically acetylation (H3K9ac) and tri-methylation (H3K9me3...
Shedding light on DNA methylation and its clinical implications: the impact of long-read-based nanopore technology
Shedding light on DNA methylation and its clinical implications: the impact of long-read-based nanopore technology
DNA methylation is an essential epigenetic mechanism for regulation of gene expression, through which many physiological (...
Dissecting the Kaiso binding profile in clear renal cancer cells
Dissecting the Kaiso binding profile in clear renal cancer cells
There has been a notable increase in interest in the transcriptional regulator Kaiso, which has been linked to the regulat...
Epigenetic control of dental stem cells: progress and prospects in multidirectional differentiation
Epigenetic control of dental stem cells: progress and prospects in multidirectional differentiation
Dental stem cells, with their exceptional proliferative capacity and multidirectional differentiation potential, hold sign...
A polycomb group protein EED epigenetically regulates responses in lipopolysaccharide tolerized macrophages
A polycomb group protein EED epigenetically regulates responses in lipopolysaccharide tolerized macrophages
To avoid exaggerated inflammation, innate immune cells adapt to become hypo-responsive or “tolerance” in respo...
VprBP regulates osteoclast differentiation via an epigenetic mechanism involving histone H2A phosphorylation
VprBP regulates osteoclast differentiation via an epigenetic mechanism involving histone H2A phosphorylation
Bone remodeling is a continuous and balanced process which relies on the dynamic equilibrium between osteoclastic bone res...
FOSL1 is a key regulator of a super-enhancer driving TCOF1 expression in triple-negative breast cancer
FOSL1 is a key regulator of a super-enhancer driving TCOF1 expression in triple-negative breast cancer
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with an unmet clinical need, but its epigen...
Chromatin structure and 3D architecture define the differential functions of PU.1 regulatory elements in blood cell lineages
Chromatin structure and 3D architecture define the differential functions of PU.1 regulatory elements in blood cell lineages
The precise spatiotemporal expression of the hematopoietic ETS transcription factor PU.1, a key determinant of hematopoiet...
H3.3K122A results in a neomorphic phenotype in mouse embryonic stem cells
H3.3K122A results in a neomorphic phenotype in mouse embryonic stem cells
Canonical histone H3 and histone variant H3.3 are posttranslationally modified with the genomic distribution of these mark...
Epigenetic frontiers: miRNAs, long non-coding RNAs and nanomaterials are pioneering to cancer therapy
Epigenetic frontiers: miRNAs, long non-coding RNAs and nanomaterials are pioneering to cancer therapy
Cancer has arisen from both genetic mutations and epigenetic changes, making epigenetics a crucial area of research for in...
Methylation patterns at the adjacent CpG sites within enhancers are a part of cell identity
Methylation patterns at the adjacent CpG sites within enhancers are a part of cell identity
It is generally accepted that methylation status of CpG sites spaced up to 50 bp apart is correlated, and accumul...
PRKACB is a novel imprinted gene in marsupials
PRKACB is a novel imprinted gene in marsupials
Genomic imprinting results in parent-of-origin-specific gene expression and, among vertebrates, is found only in therian m...
Transcriptional silencing in Saccharomyces cerevisiae: known unknowns
Transcriptional silencing in Saccharomyces cerevisiae: known unknowns
Transcriptional silencing in Saccharomyces cerevisiae is a persistent and highly stable form of gene repression. It involv...
The role of hexokinases in epigenetic regulation: altered hexokinase expression and chromatin stability in yeast
The role of hexokinases in epigenetic regulation: altered hexokinase expression and chromatin stability in yeast
Human hexokinase 2 (HK2) plays an important role in regulating Warburg effect, which metabolizes glucose to lactate acid e...
Transcriptional regulation mechanism of PARP1 and its application in disease treatment
Transcriptional regulation mechanism of PARP1 and its application in disease treatment
Poly (ADP-ribose) polymerase 1 (PARP1) is a multifunctional nuclear enzyme that catalyzes poly-ADP ribosylation in eukaryo...
DNA methylation correlates of chronological age in diverse human tissue types
DNA methylation correlates of chronological age in diverse human tissue types
While the association of chronological age with DNA methylation (DNAm) in whole blood has been extensively studied, the ti...
Long-term exposure to diesel exhaust particles induces concordant changes in DNA methylation and transcriptome in human adenocarcinoma alveolar basal epithelial cells
Long-term exposure to diesel exhaust particles induces concordant changes in DNA methylation and transcriptome in human adenocarcinoma alveolar basal epithelial cells
Diesel exhaust particles (DEP), which contain hazardous compounds, are emitted during the combustion of diesel. As approxi...
The role of ribosomal DNA methylation in embryonic development, aging and diseases
The role of ribosomal DNA methylation in embryonic development, aging and diseases
The ribosomal DNA (rDNA) constitutes a remarkably conserved DNA sequence within species, located in the area of the nucleo...
CUT&Tag applied to zebrafish adult tail fins reveals a return of embryonic H3K4me3 patterns during regeneration
CUT&Tag applied to zebrafish adult tail fins reveals a return of embryonic H3K4me3 patterns during regeneration
Regenerative potential is governed by a complex process of transcriptional reprogramming, involving chromatin reorganizati...
CREdb: A comprehensive database of Cis-Regulatory Elements and their activity in human cells and tissues
CREdb: A comprehensive database of Cis-Regulatory Elements and their activity in human cells and tissues
Cis-regulatory elements (CREs) play a pivotal role in gene expression regulation, allowing cells to serve diverse function...
Imprinted DNA methylation of the H19 ICR is established and maintained in vivo in the absence of Kaiso
Imprinted DNA methylation of the H19 ICR is established and maintained in vivo in the absence of Kaiso
Paternal allele-specific DNA methylation of the imprinting control region (H19 ICR) controls genomic imprinting at the Igf...
Native and tagged CENP-A histones are functionally inequivalent
Native and tagged CENP-A histones are functionally inequivalent
Over the past several decades, the use of biochemical and fluorescent tags has elucidated mechanistic and cytological proc...
From compartments to loops: understanding the unique chromatin organization in neuronal cells
From compartments to loops: understanding the unique chromatin organization in neuronal cells
The three-dimensional organization of the genome plays a central role in the regulation of cellular functions, particularl...
Su(Hw) interacts with Combgap to establish long-range chromatin contacts
Su(Hw) interacts with Combgap to establish long-range chromatin contacts
Insulator-binding proteins (IBPs) play a critical role in genome architecture by forming and maintaining contact domains. ...
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