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Vasoactive Intestinal Peptide (VIP) and its Receptors in Adipose Tissue: Implications for Cold Stress Adaptation
Vasoactive Intestinal Peptide (VIP) and its Receptors in Adipose Tissue: Implications for Cold Stress Adaptation
Adipose tissue represents an organ that is highly dynamic and contributes toward vital survival events such as immune resp...
Numerical Simulations and Bifurcation of Ca2+ Oscillatory Behaviour in the Connection of Neurons and Astrocytes
Numerical Simulations and Bifurcation of Ca2+ Oscillatory Behaviour in the Connection of Neurons and Astrocytes
Extensive research has demonstrated that astrocytes actively participate in the regulation of synaptic communication. To e...
Impairing Ferroptosis Through the PI3K/Akt/Nrf2 Pathway: The Way for Nerve Growth Factor to Mitigate Hypoxia-induced Cardiomyocyte Damage
Impairing Ferroptosis Through the PI3K/Akt/Nrf2 Pathway: The Way for Nerve Growth Factor to Mitigate Hypoxia-induced Cardiomyocyte Damage
Myocardial infarction (MI) is an acute cardiovascular diseases, distinguished primarily by cardiomyocyte damage due to isc...
Phytochemicals in Parkinson’s Disease: a Pathway to Neuroprotection and Personalized Medicine
Phytochemicals in Parkinson’s Disease: a Pathway to Neuroprotection and Personalized Medicine
Parkinson’s disease (PD) is a complex neurodegenerative disorder marked by the progressive loss of dopaminergic neur...
Exploring the Updated Roles of Ferroptosis in Liver Diseases: Mechanisms, Regulators, and Therapeutic Implications
Exploring the Updated Roles of Ferroptosis in Liver Diseases: Mechanisms, Regulators, and Therapeutic Implications
Ferroptosis, a newly discovered mode of cell death, is a type of iron-dependent regulated cell death characterized by intr...
MicroRNA 223 Enhances ABCA1 Protein Stability and Supports Efflux in Cholesterol-Burdened Macrophages
MicroRNA 223 Enhances ABCA1 Protein Stability and Supports Efflux in Cholesterol-Burdened Macrophages
Macrophages are present in all vertebrates as part of the innate immune system, which protects from pathogens and scavenge...
Autophagy in Acute Lung Injury
Autophagy in Acute Lung Injury
Acute lung injury (ALI) is a critical condition marked by rapid-onset respiratory failure due to extensive inflammation an...
A Computational Approach to Characterize the Protein S-Mer Tyrosine Kinase (PROS1-MERTK) Protein-Protein Interaction Dynamics
A Computational Approach to Characterize the Protein S-Mer Tyrosine Kinase (PROS1-MERTK) Protein-Protein Interaction Dynamics
Protein S (PROS1) has recently been identified as a ligand for the TAM receptor MERTK, influencing immune response and cel...
Flavonoids of Euphorbia hirta inhibit inflammatory mechanisms via Nrf2 and NF-κB pathways
Flavonoids of Euphorbia hirta inhibit inflammatory mechanisms via Nrf2 and NF-κB pathways
Euphorbia hirta has anti-inflammatory effects in traditional medicine, but its anti-inflammatory mechanism has not been ex...
Mechanism of the KIAA1429/KLF1/PD-L1 Axis in Regulating Immune Escape in Non-small Cell Lung Cancer
Mechanism of the KIAA1429/KLF1/PD-L1 Axis in Regulating Immune Escape in Non-small Cell Lung Cancer
Non-small cell lung cancer (NSCLC), accounting for approximately 80% of lung cancer cases, remains the leading cause of ca...
Biochanin A Attenuates Psoriasiform Inflammation by Regulating Nrf2/HO-1 Pathway Activation and Attenuating Inflammatory Signalling
Biochanin A Attenuates Psoriasiform Inflammation by Regulating Nrf2/HO-1 Pathway Activation and Attenuating Inflammatory Signalling
Psoriasis is a long-term inflammatory skin condition marked by an overabundance of keratinocytes and the release of pro-in...
Non-coding RNAs as a Critical Player in the Regulation of Inflammasome in Inflammatory Bowel Diseases; Emphasize on lncRNAs
Non-coding RNAs as a Critical Player in the Regulation of Inflammasome in Inflammatory Bowel Diseases; Emphasize on lncRNAs
Inflammatory bowel disease (IBD) is an idiopathic disease caused by a dysregulated immune response to host intestinal micr...
Advanced Bio-sensing Technologies for Sickle Cell Disease Diagnosis
Advanced Bio-sensing Technologies for Sickle Cell Disease Diagnosis
Sickle cell diseases are widespread in regions encompassing the Mediterranean, Middle East, sub-Saharan Africa, and specif...
Immune Effect of Co-Culture of Dendritic Cells and Cytokine-Induced Killer Cells on Prostate Cancer Cells
Immune Effect of Co-Culture of Dendritic Cells and Cytokine-Induced Killer Cells on Prostate Cancer Cells
It was to explore the immune outcome of co-culture of dendritic cells (DC) and cytokine-induced killer cells (CIK) on pros...
Allicin Ameliorated High-glucose Peritoneal Dialysis Solution-induced Peritoneal Fibrosis in Rats via the JAK2/STAT3 Signaling Pathway
Allicin Ameliorated High-glucose Peritoneal Dialysis Solution-induced Peritoneal Fibrosis in Rats via the JAK2/STAT3 Signaling Pathway
Peritoneal fibrosis (PF) is one of the most serious complications of peritoneal dialysis (PD) and is the greatest obstacle...
METTL14 Promotes Ischemic Stroke-induced Brain Injury by Stabilizing HDAC3 Expression in an m6A-IGF2BP3 Mechanism
METTL14 Promotes Ischemic Stroke-induced Brain Injury by Stabilizing HDAC3 Expression in an m6A-IGF2BP3 Mechanism
N6-methyladenosine (m6A) modification is the most abundant post-transcriptional modification of mRNAs and has been identif...
CKIP-1 inhibits M2 macrophage polarization to suppress the progression of gastric cancer by inactivating JAK/STAT3 signaling
CKIP-1 inhibits M2 macrophage polarization to suppress the progression of gastric cancer by inactivating JAK/STAT3 signaling
Gastric cancer (GC) is a frequently occurring malignancy with poor prognosis. Casein kinase 2 interacting protein-1 (CKIP-...
Nyctanthes arbor-tristis Improves Blood Pressure via Endothelial Pathway: In Silico, Ex Vivo, and In Vivo Evidence
Nyctanthes arbor-tristis Improves Blood Pressure via Endothelial Pathway: In Silico, Ex Vivo, and In Vivo Evidence
Systemic hypertension, a common metabolic disorder, poses significant health risks despite the availability of antihyperte...
Impact of ERG6 Gene Deletion on Membrane Composition and Properties in the Pathogenic Yeast Candida glabrata
Impact of ERG6 Gene Deletion on Membrane Composition and Properties in the Pathogenic Yeast Candida glabrata
The ERG6 gene is crucial for the biosynthesis of ergosterol, a key component of yeast cell membranes. Our study examines t...
In silico genome-wide analysis of the growth-regulating factor gene family and their expression profiling in Vitis vinifera under biotic stress
In silico genome-wide analysis of the growth-regulating factor gene family and their expression profiling in Vitis vinifera under biotic stress
Growth regulatory factors (GRFs) are transcription factors that encode the proteins involved in plant growth and developme...
CORO1C Regulates the Malignant Biological Behavior of Ovarian Cancer Cells and Modulates the mRNA Expression Profile through the PI3K/AKT Signaling Pathway
CORO1C Regulates the Malignant Biological Behavior of Ovarian Cancer Cells and Modulates the mRNA Expression Profile through the PI3K/AKT Signaling Pathway
Ovarian cancer (OC) is a frequently occurring gynecological tumor, and its global incidence has recently increased. Coroni...
The Protective Role of Baicalin in the Regulation of NLRP3 Inflammasome in Different Diseases
The Protective Role of Baicalin in the Regulation of NLRP3 Inflammasome in Different Diseases
The NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome consists of pro-caspase-1, NLRP3 and apoptosis-r...
Unveiling Stingless Bee Honey Anti-inflammatory Potential Through the Polarization of LPS-induced J774 Macrophages
Unveiling Stingless Bee Honey Anti-inflammatory Potential Through the Polarization of LPS-induced J774 Macrophages
Macrophages play an important role during the inflammatory process. These cells can adopt either the pro- or anti-inflamma...
Ensuring Clinical Excellence: The Mindray SAL9000 Biochemical Immunoassay System
Ensuring Clinical Excellence: The Mindray SAL9000 Biochemical Immunoassay System
This study aimed to evaluate the performance and clinical laboratory adaptability of the Mindray SAL9000 biochemical immun...
Ginsenoside 20(S)-Rg3 Hinders Esophageal Squamous Cell Carcinoma Cells Malignant Behaviors by miR-210-3p/B4GALT5 Axis
Ginsenoside 20(S)-Rg3 Hinders Esophageal Squamous Cell Carcinoma Cells Malignant Behaviors by miR-210-3p/B4GALT5 Axis
Ginsenoside 20(S)-Rg3 (20(S)-Rg3) belongs to a natural chemical with an anti-tumor function, but its potential function an...
Proteostasis and Its Role in Disease Development
Proteostasis and Its Role in Disease Development
Proteostasis (protein homeostasis) refers to the general biological process that maintains the proper balance between the ...
Histone Deacetylases (HDACs) Roles in Inflammation-mediated Diseases; Current Knowledge
Histone Deacetylases (HDACs) Roles in Inflammation-mediated Diseases; Current Knowledge
The histone acetyl transferases (HATs) and histone deacetylases (HDACs), which are mostly recognized for their involvement...
β-Sitosterol Mitigates Apoptosis, Oxidative Stress and Inflammatory Response by Inactivating TLR4/NF-кB Pathway in Cell Models of Diabetic Nephropathy
β-Sitosterol Mitigates Apoptosis, Oxidative Stress and Inflammatory Response by Inactivating TLR4/NF-кB Pathway in Cell Models of Diabetic Nephropathy
Podocyte injury plays a pivotal role in the pathogenesis of diabetic nephropathy (DN), leading to proteinuria formation. &...
Insights on the Characteristics and Therapeutic Potential of Mesenchymal Stem Cell-derived Exosomes for Mitigation of Alzheimer’s Disease’s Pathogenicity: A Systematic Review
Insights on the Characteristics and Therapeutic Potential of Mesenchymal Stem Cell-derived Exosomes for Mitigation of Alzheimer’s Disease’s Pathogenicity: A Systematic Review
Alzheimer’s disease (AD) remains a progressive neurodegenerative disease with no cure. Treatment of AD relies on adm...
The Anti-proliferative Effect, Apoptotic Induction, and Cell Cycle Arrest of Tetra Halo Ruthenate Nanocomposites in Different Human Cancer Cell Lines
The Anti-proliferative Effect, Apoptotic Induction, and Cell Cycle Arrest of Tetra Halo Ruthenate Nanocomposites in Different Human Cancer Cell Lines
Chemotherapy is the most common cancer treatment, and metallic anticancer compounds have generated increasing amounts of i...
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