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Assessment of cephalometric parameters and correlation with the severity of the obstructive sleep apnea syndrome
Assessment of cephalometric parameters and correlation with the severity of the obstructive sleep apnea syndrome
In individuals diagnosed with obstructive sleep apnea syndrome (OSAS), variations in craniofacial structure have been inco...
The redox-active defensive Selenoprotein T as a novel stress sensor protein playing a key role in the pathophysiology of heart failure
The redox-active defensive Selenoprotein T as a novel stress sensor protein playing a key role in the pathophysiology of heart failure
Maladaptive cardiac hypertrophy contributes to the development of heart failure (HF). The oxidoreductase Selenoprotein T (...
Mutational landscape of inflammatory breast cancer
Mutational landscape of inflammatory breast cancer
Inflammatory breast cancer (IBC) is the most pro-metastatic form of BC. Better understanding of its enigmatic pathophysiol...
Dissecting the shared genetic landscape of anxiety, depression, and schizophrenia
Dissecting the shared genetic landscape of anxiety, depression, and schizophrenia
Numerous studies highlight the genetic underpinnings of mental disorders comorbidity, particularly in anxiety, depression,...
Short-chain fatty acid-producing bacterial strains attenuate experimental ulcerative colitis by promoting M2 macrophage polarization via JAK/STAT3/FOXO3 axis inactivation
Short-chain fatty acid-producing bacterial strains attenuate experimental ulcerative colitis by promoting M2 macrophage polarization via JAK/STAT3/FOXO3 axis inactivation
Patients with inflammatory bowel disease (IBD), dysbiosis, and immunosuppression who receive fecal microbiota transplantat...
Implications of ZNF334 gene in lymph node metastasis of lung SCC: potential bypassing of cellular senescence
Implications of ZNF334 gene in lymph node metastasis of lung SCC: potential bypassing of cellular senescence
The primary goal of this work is to identify biomarkers associated with lung squamous cell carcinoma and assess their pote...
The development of chimeric antigen receptor T-cells against CD70 for renal cell carcinoma treatment
The development of chimeric antigen receptor T-cells against CD70 for renal cell carcinoma treatment
In this study, we investigated CD70 as a promising target for renal cell carcinoma (RCC) therapy and developed a potent ch...
Mesothelin-based CAR-T cells exhibit potent antitumor activity against ovarian cancer
Mesothelin-based CAR-T cells exhibit potent antitumor activity against ovarian cancer
Ovarian cancer (OC) is characterized by its rapid growth and spread which, accompanied by a low 5-year survival rate, nece...
Application of high-precision 3D scanner in keloids evaluation to improve patients’ compliance: a questionnaire-based study
Application of high-precision 3D scanner in keloids evaluation to improve patients’ compliance: a questionnaire-based study
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Machine learning and optical coherence tomography-derived radiomics analysis to predict persistent diabetic macular edema in patients undergoing anti-VEGF intravitreal therapy
Machine learning and optical coherence tomography-derived radiomics analysis to predict persistent diabetic macular edema in patients undergoing anti-VEGF intravitreal therapy
Diabetic macular edema (DME) is a leading cause of vision loss in patients with diabetes. This study aimed to develop and ...
Enhancing prediction accuracy of coronary artery disease through machine learning-driven genomic variant selection
Enhancing prediction accuracy of coronary artery disease through machine learning-driven genomic variant selection
Machine learning (ML) methods are increasingly becoming crucial in genome-wide association studies for identifying key gen...
Stromal cartilage oligomeric matrix protein as a tumorigenic driver in ovarian cancer via Notch3 signaling and epithelial-to-mesenchymal transition
Stromal cartilage oligomeric matrix protein as a tumorigenic driver in ovarian cancer via Notch3 signaling and epithelial-to-mesenchymal transition
Cartilage oligomeric matrix protein (COMP), an extracellular matrix glycoprotein, is vital in preserving cartilage integri...
Nicotine restores olfactory function by activation of prok2R/Akt/FoxO3a axis in Parkinson’s disease
Nicotine restores olfactory function by activation of prok2R/Akt/FoxO3a axis in Parkinson’s disease
Olfactory dysfunction occurs frequently in Parkinson’s disease (PD). In this study, we aimed to explore the potentia...
Immersed in a reservoir of potential: amniotic fluid-derived extracellular vesicles
Immersed in a reservoir of potential: amniotic fluid-derived extracellular vesicles
This review aims to encapsulate the current knowledge in extracellular vesicles extracted from amniotic fluid and amniotic...
Development of nanobodies targeting hepatocellular carcinoma and application of nanobody-based CAR-T technology
Development of nanobodies targeting hepatocellular carcinoma and application of nanobody-based CAR-T technology
Chimeric antigen receptor T (CAR-T) cell therapy, as an emerging anti-tumor treatment, has garnered extensive attention in...
THOC7-AS1/OCT1/FSTL1 axis promotes EMT and serves as a therapeutic target in cutaneous squamous cell carcinoma
THOC7-AS1/OCT1/FSTL1 axis promotes EMT and serves as a therapeutic target in cutaneous squamous cell carcinoma
THOC7-AS1 and FSTL1 expression are frequently upregulated in cutaneous squamous cell carcinoma (cSCC). However, their mole...
The integration of single-cell and bulk RNA-seq atlas reveals ERS-mediated acinar cell damage in acute pancreatitis
The integration of single-cell and bulk RNA-seq atlas reveals ERS-mediated acinar cell damage in acute pancreatitis
Acute pancreatitis (AP) is a clinically common acute abdominal disease, whose pathogenesis remains unclear. The severe pat...
Longitudinal study of the impact of the COVID-19 pandemic on diet and physical activity among Latinos of Mexican ancestry
Longitudinal study of the impact of the COVID-19 pandemic on diet and physical activity among Latinos of Mexican ancestry
The COVID-19 pandemic caused societal disruption in the United States and most of the world, affecting many aspects of lif...
Liposomes, transfersomes and niosomes: production methods and their applications in the vaccinal field
Liposomes, transfersomes and niosomes: production methods and their applications in the vaccinal field
One of the most effective strategies to fight viruses and handle health diseases is vaccination. Recent studies and curren...
Increased risk of psychiatric disorder in patients with hearing loss: a nationwide population-based cohort study
Increased risk of psychiatric disorder in patients with hearing loss: a nationwide population-based cohort study
Hearing loss has been shown to be a risk factor for psychiatric disorders. In addition, long-term hearing loss is associat...
Association of circulating biomarkers with illness severity measures differentiates myalgic encephalomyelitis/chronic fatigue syndrome and post-COVID-19 condition: a prospective pilot cohort study
Association of circulating biomarkers with illness severity measures differentiates myalgic encephalomyelitis/chronic fatigue syndrome and post-COVID-19 condition: a prospective pilot cohort study
Accumulating evidence suggests that autonomic dysfunction and persistent systemic inflammation are common clinical feature...
Lack of shared neoantigens in prevalent mutations in cancer
Lack of shared neoantigens in prevalent mutations in cancer
Tumors are mostly characterized by genetic instability, as result of mutations in surveillance mechanisms, such as DNA dam...
CDC45 promotes the stemness and metastasis in lung adenocarcinoma by affecting the cell cycle
CDC45 promotes the stemness and metastasis in lung adenocarcinoma by affecting the cell cycle
This study aimed to assess the functions of cell division cycle protein 45 (CDC45) in Non-small cell lung cancer (NSCLC) c...
CD137+ and regulatory T cells as independent prognostic factors of survival in advanced non-oncogene addicted NSCLC patients treated with immunotherapy as first-line
CD137+ and regulatory T cells as independent prognostic factors of survival in advanced non-oncogene addicted NSCLC patients treated with immunotherapy as first-line
Immune checkpoint inhibitors (ICIs), administered alone or combined with chemotherapy, are the standard of care in advance...
Edge-based relative entropy as a sensitive indicator of critical transitions in biological systems
Edge-based relative entropy as a sensitive indicator of critical transitions in biological systems
Disease progression in biosystems is not always a steady process but is occasionally abrupt. It is important but challengi...
Development and validation of a model and nomogram for breast cancer diagnosis based on quantitative analysis of serum disease-specific haptoglobin N-glycosylation
Development and validation of a model and nomogram for breast cancer diagnosis based on quantitative analysis of serum disease-specific haptoglobin N-glycosylation
A better diagnostic marker is in need to distinguish breast cancer from suspicious breast lesions. The abnormal glycosylat...
Intestinal Piezo1 aggravates intestinal barrier dysfunction during sepsis by mediating Ca2+ influx
Intestinal Piezo1 aggravates intestinal barrier dysfunction during sepsis by mediating Ca2+ influx
Intestinal barrier dysfunction is a pivotal factor in sepsis progression. The mechanosensitive ion channel Piezo1 is assoc...
Systematic proteome-wide Mendelian randomization using the human plasma proteome to identify therapeutic targets for lung adenocarcinoma
Systematic proteome-wide Mendelian randomization using the human plasma proteome to identify therapeutic targets for lung adenocarcinoma
Lung adenocarcinoma (LUAD) is the predominant histological subtype of lung cancer and the leading cause of cancer-related ...
Double-negative T cells ameliorate psoriasis by selectively inhibiting IL-17A-producing γδlow T cells
Double-negative T cells ameliorate psoriasis by selectively inhibiting IL-17A-producing γδlow T cells
Psoriasis is a chronic immune-mediated skin condition. Although biologic treatments are effective in controlling psoriasis...
Regulatory role of PI16 in autoimmune arthritis and intestinal inflammation: implications for Treg cell differentiation and function
Regulatory role of PI16 in autoimmune arthritis and intestinal inflammation: implications for Treg cell differentiation and function
Regulatory T cells (Tregs) are crucial in maintaining immune homeostasis and preventing autoimmunity and inflammation. A p...
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