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Interactions between patterns of multimorbidity and functional status among hospitalized older patients: a novel approach using cluster analysis and association rule mining
Interactions between patterns of multimorbidity and functional status among hospitalized older patients: a novel approach using cluster analysis and association rule mining
Multimorbidity (MM) is generally defined as the presence of 2 or more chronic diseases in the same patient and seems to be...
Peripheral whole blood microRNA expression in relation to vascular function: a population-based study
Peripheral whole blood microRNA expression in relation to vascular function: a population-based study
As key regulators of gene expression, microRNAs affect many cardiovascular mechanisms and have been associated with severa...
Exploring lipin1 as a promising therapeutic target for the treatment of Duchenne muscular dystrophy
Exploring lipin1 as a promising therapeutic target for the treatment of Duchenne muscular dystrophy
Duchenne muscular dystrophy (DMD) is a progressive and devastating muscle disease, resulting from the absence of dystrophi...
Untargeted blood serum proteomics identifies novel proteins related to neurological recovery after human spinal cord injury
Untargeted blood serum proteomics identifies novel proteins related to neurological recovery after human spinal cord injury
The discovery of new prognostic biomarkers following spinal cord injury (SCI) is a rapidly growing field that could help u...
HER3 receptor and its role in the therapeutic management of metastatic breast cancer
HER3 receptor and its role in the therapeutic management of metastatic breast cancer
Metastatic breast cancer (mBC) poses a significant threat to women's health and is a major cause of malignant neoplasm...
Identification and experimental validation of KMO as a critical immune-associated mitochondrial gene in unstable atherosclerotic plaque
Identification and experimental validation of KMO as a critical immune-associated mitochondrial gene in unstable atherosclerotic plaque
The heightened risk of cardiovascular and cerebrovascular events is associated with the increased instability of atheroscl...
Chlorpromazine overcomes temozolomide resistance in glioblastoma by inhibiting Cx43 and essential DNA repair pathways
Chlorpromazine overcomes temozolomide resistance in glioblastoma by inhibiting Cx43 and essential DNA repair pathways
In the fight against GBM, drug repurposing emerges as a viable and time-saving approach to explore new treatment options. ...
An overview of CCN4 (WISP1) role in human diseases
An overview of CCN4 (WISP1) role in human diseases
CCN4 (cellular communication network factor 4), a highly conserved, secreted cysteine-rich matricellular protein is emergi...
Multiomic analysis of monocyte-derived alveolar macrophages in idiopathic pulmonary fibrosis
Multiomic analysis of monocyte-derived alveolar macrophages in idiopathic pulmonary fibrosis
Monocyte-derived alveolar macrophages (Mo_AMs) are increasingly recognised as potential pathogenic factors for idiopathic ...
Macrophages as determinants and regulators of systemic sclerosis-related interstitial lung disease
Macrophages as determinants and regulators of systemic sclerosis-related interstitial lung disease
Interstitial lung disease (ILD) is the primary cause of mortality in systemic sclerosis (SSc), an autoimmune disease chara...
Cancer-associated fibroblasts (CAFs) gene signatures predict outcomes in breast and prostate tumor patients
Cancer-associated fibroblasts (CAFs) gene signatures predict outcomes in breast and prostate tumor patients
Over the last two decades, tumor-derived RNA expression signatures have been developed for the two most commonly diagnosed...
Exploring the oncogenic potential of circSOD2 in clear cell renal cell carcinoma: a novel positive feedback loop
Exploring the oncogenic potential of circSOD2 in clear cell renal cell carcinoma: a novel positive feedback loop
Existing studies have found that circular RNAs (circRNAs) act as sponges for micro RNAs (miRNAs) to control downstream gen...
circSORBS1 inhibits lung cancer progression by sponging miR-6779-5p and directly binding RUFY3 mRNA
circSORBS1 inhibits lung cancer progression by sponging miR-6779-5p and directly binding RUFY3 mRNA
Lung cancer is the primary cause of cancer-related death worldwide, and its global incidence and mortality rates remain hi...
Siderophore-harboring gut bacteria and fecal siderophore genes for predicting the responsiveness of fecal microbiota transplantation for active ulcerative colitis
Siderophore-harboring gut bacteria and fecal siderophore genes for predicting the responsiveness of fecal microbiota transplantation for active ulcerative colitis
Predictive markers for fecal microbiota transplantation (FMT) outcomes in patients with active ulcerative colitis (UC) are...
Mitochondrial GCN5L1 acts as a novel regulator for iron homeostasis to promote sorafenib sensitivity in hepatocellular carcinoma
Mitochondrial GCN5L1 acts as a novel regulator for iron homeostasis to promote sorafenib sensitivity in hepatocellular carcinoma
Sorafenib resistance is becoming increasingly common and disadvantageous for hepatocellular carcinoma (HCC) treatment. Fer...
Interplay of Mediterranean-diet adherence, genetic factors, and metabolic dysfunction-associated steatotic liver disease risk in Korea
Interplay of Mediterranean-diet adherence, genetic factors, and metabolic dysfunction-associated steatotic liver disease risk in Korea
Metabolic dysfunction-associated steatotic liver disease (MASLD) has gained attention owing to its severe complications. T...
Cross-species transcriptomics identifies obesity associated genes between human and mouse studies
Cross-species transcriptomics identifies obesity associated genes between human and mouse studies
Fundamentally defined by an imbalance in energy consumption and energy expenditure, obesity is a significant risk factor o...
Novel hypoxia- and lactate metabolism-related molecular subtyping and prognostic signature for colorectal cancer
Novel hypoxia- and lactate metabolism-related molecular subtyping and prognostic signature for colorectal cancer
Colorectal cancer (CRC) is a serious global health burden because of its high morbidity and mortality rates. Hypoxia and m...
Circ_0004851 regulates the molecular mechanism of miR-296-3p/FGF11 in the influence of high iodine on PTC
Circ_0004851 regulates the molecular mechanism of miR-296-3p/FGF11 in the influence of high iodine on PTC
The prevalence of papillary thyroid cancer (PTC) has been rising in recent years. Despite its relatively low mortality, PT...
Integrating DNA/RNA microbe detection and host response for accurate diagnosis, treatment and prognosis of childhood infectious meningitis and encephalitis
Integrating DNA/RNA microbe detection and host response for accurate diagnosis, treatment and prognosis of childhood infectious meningitis and encephalitis
Infectious meningitis/encephalitis (IM) is a severe neurological disease that can be caused by bacterial, viral, and funga...
Regulation of vascular endothelial integrity by mesenchymal stem cell extracellular vesicles after hemorrhagic shock and trauma
Regulation of vascular endothelial integrity by mesenchymal stem cell extracellular vesicles after hemorrhagic shock and trauma
Patients with hemorrhagic shock and trauma (HS/T) are vulnerable to the endotheliopathy of trauma (EOT), characterized by ...
Functional genetic variants of GEN1 predict overall survival of Chinese epithelial ovarian cancer patients
Functional genetic variants of GEN1 predict overall survival of Chinese epithelial ovarian cancer patients
Inherited variations in DNA double-strand break (DSB) repair pathway are known to influence ovarian cancer occurrence, pro...
Mutational variant allele frequency profile as a biomarker of response to immune checkpoint blockade in non-small cell lung Cancer
Mutational variant allele frequency profile as a biomarker of response to immune checkpoint blockade in non-small cell lung Cancer
Identifying new biomarkers for predicting immune checkpoint inhibitors (ICIs) response in non-small cell lung cancer (NSCL...
Genetic perturbation of IL-6 receptor signaling pathway and risk of multiple respiratory diseases
Genetic perturbation of IL-6 receptor signaling pathway and risk of multiple respiratory diseases
Dysregulation of inflammation can lead to multiple chronic respiratory diseases, such as chronic obstructive pulmonary dis...
IFIT1 + neutrophil is a causative factor of immunosuppressive features of poorly cohesive carcinoma (PCC)
IFIT1 + neutrophil is a causative factor of immunosuppressive features of poorly cohesive carcinoma (PCC)
The importance of the immune microenvironment in poorly cohesive carcinoma (PCC) has been highlighted due to its limited r...
Exosomes multiplex profiling, a promising strategy for early diagnosis of laryngeal cancer
Exosomes multiplex profiling, a promising strategy for early diagnosis of laryngeal cancer
Exosomes are nanosized vesicles released from all cells into surrounding biofluids, including cancer cells, and represent ...
Vaginal microbial profile of cervical cancer patients receiving chemoradiotherapy: the potential involvement of Lactobacillus iners in recurrence
Vaginal microbial profile of cervical cancer patients receiving chemoradiotherapy: the potential involvement of Lactobacillus iners in recurrence
The vaginal microbiome is an immune defense against reproductive diseases and can serve as an important biomarker for cerv...
Unveiling divergent treatment prognoses in IDHwt-GBM subtypes through multiomics clustering: a swift dual MRI-mRNA model for precise subtype prediction
Unveiling divergent treatment prognoses in IDHwt-GBM subtypes through multiomics clustering: a swift dual MRI-mRNA model for precise subtype prediction
IDH1-wildtype glioblastoma multiforme (IDHwt-GBM) is a highly heterogeneous and aggressive brain tumour characterised by a...
Gut microbiota-derived acetate attenuates lung injury induced by influenza infection via protecting airway tight junctions
Gut microbiota-derived acetate attenuates lung injury induced by influenza infection via protecting airway tight junctions
Gut microbiota (GM) have been implicated as important regulators of gastrointestinal symptom which is commonly occurred al...
Accurate prediction of drug combination risk levels based on relational graph convolutional network and multi-head attention
Accurate prediction of drug combination risk levels based on relational graph convolutional network and multi-head attention
Accurately identifying the risk level of drug combinations is of great significance in investigating the mechanisms of com...
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