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Proteome-wide mendelian randomization study implicates therapeutic targets in common cancers
Proteome-wide mendelian randomization study implicates therapeutic targets in common cancers
The interest in targeted cancer therapies has been growing rapidly. While numerous cancer biomarkers and targeted treatmen...
Identification of memory B-cell-associated miRNA signature to establish a prognostic model in gastric adenocarcinoma
Identification of memory B-cell-associated miRNA signature to establish a prognostic model in gastric adenocarcinoma
Memory B cells and microRNAs (miRNAs) play important roles in the progression of gastric adenocarcinoma (GAC), also known ...
SIRT1 activation promotes energy homeostasis and reprograms liver cancer metabolism
SIRT1 activation promotes energy homeostasis and reprograms liver cancer metabolism
Cancer cells are characterized by uncontrolled cell proliferation and impaired bioenergetics. Sirtuins are a family of hig...
Deep dissection of stemness-related hierarchies in hepatocellular carcinoma
Deep dissection of stemness-related hierarchies in hepatocellular carcinoma
Increasing evidence suggests that hepatocellular carcinoma (HCC) stem cells (LCSCs) play an essential part in HCC recurren...
A novel NET-related gene signature for predicting DLBCL prognosis
A novel NET-related gene signature for predicting DLBCL prognosis
Diffuse large B-cell lymphoma (DLBCL) is an aggressive malignancy. Neutrophil extracellular traps (NETs) are pathogen-trap...
Non-coding RNAs/DNMT3B axis in human cancers: from pathogenesis to clinical significance
Non-coding RNAs/DNMT3B axis in human cancers: from pathogenesis to clinical significance
Cancer is a complex disease with many contributing factors, and researchers have gained extensive knowledge that has helpe...
Association between life’s essential 8 and biological ageing among US adults
Association between life’s essential 8 and biological ageing among US adults
Biological ageing is tightly linked to cardiovascular disease (CVD). We aimed to investigate the relationship between Life...
Metastasis organotropism in colorectal cancer: advancing toward innovative therapies
Metastasis organotropism in colorectal cancer: advancing toward innovative therapies
Distant metastasis remains a leading cause of mortality among patients with colorectal cancer (CRC). Organotropism, referr...
CD39 and LDHA affects the prognostic role of NLR in metastatic melanoma patients treated with immunotherapy
CD39 and LDHA affects the prognostic role of NLR in metastatic melanoma patients treated with immunotherapy
Identifying response markers is highly needed to guide the treatment strategy in patients with metastatic melanoma. A retr...
Methods of ex vivo analysis of tissue status in vascularized composite allografts
Methods of ex vivo analysis of tissue status in vascularized composite allografts
Vascularized composite allotransplantation can improve quality of life and restore functionality. However, the complex tis...
Application of radiomics-based multiomics combinations in the tumor microenvironment and cancer prognosis
Application of radiomics-based multiomics combinations in the tumor microenvironment and cancer prognosis
The advent of immunotherapy, a groundbreaking advancement in cancer treatment, has given rise to the prominence of the tum...
Cantharidin induces apoptosis of human triple negative breast cancer cells through mir-607-mediated downregulation of EGFR
Cantharidin induces apoptosis of human triple negative breast cancer cells through mir-607-mediated downregulation of EGFR
Triple negative breast cancer (TNBC) is a major subtype of breast cancer, with limited therapeutic drugs in clinical. Epid...
RAS signaling and immune cells: a sinister crosstalk in the tumor microenvironment
RAS signaling and immune cells: a sinister crosstalk in the tumor microenvironment
The rat sarcoma virus (RAS) gene is the most commonly mutated oncogene in cancer, with about 19% of cancer patients carryi...
Ligand-based adoptive T cell targeting CA125 in ovarian cancer
Ligand-based adoptive T cell targeting CA125 in ovarian cancer
Ovarian cancer (OC) is a highly aggressive gynecological malignancy prevalent worldwide. Most OC cases are typically diagn...
Osteonecrosis of the jaw induced by immune checkpoint inhibitors: an urgent need for attention
Osteonecrosis of the jaw induced by immune checkpoint inhibitors: an urgent need for attention
Author notesXinya Li and Zaiwei Song contributed equally to this work.Authors and AffiliationsDepartment of Pharmacy, Peki...
STING signaling activation modulates macrophage polarization via CCL2 in radiation-induced lung injury
STING signaling activation modulates macrophage polarization via CCL2 in radiation-induced lung injury
Radiation-induced lung injury (RILI) is a prevalent complication of thoracic radiotherapy in cancer patients. A comprehens...