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Does preeclampsia impact the gut microbiota of preterm offspring during early infancy?
Does preeclampsia impact the gut microbiota of preterm offspring during early infancy?
Preeclampsia (PE) is a pregnancy complication characterized by high blood pressure and organ damage. This study investigat...
The role of laminins in cancer pathobiology: a comprehensive review
The role of laminins in cancer pathobiology: a comprehensive review
Laminins (LMs) are a family of heterotrimeric glycoproteins that form the structural foundation of basement membranes (BM)...
PRDX2 induces tumor immune evasion by modulating the HDAC3-Galectin-9 axis in lung adenocarcinoma cells
PRDX2 induces tumor immune evasion by modulating the HDAC3-Galectin-9 axis in lung adenocarcinoma cells
PRDX2 is significantly expressed in various cancers and is associated with the proliferation of tumor cells. Nonetheless, ...
KEAP1 mutations as key crucial prognostic biomarkers for resistance to KRAS-G12C inhibitors
KEAP1 mutations as key crucial prognostic biomarkers for resistance to KRAS-G12C inhibitors
KRAS-G12C inhibitors mark a notable advancement in targeted cancer therapies, yet identifying predictive biomarkers for tr...
Single-cell transcriptomic analysis reveals characteristic feature of macrophage reprogramming in liver Mallory-Denk bodies pathogenesis
Single-cell transcriptomic analysis reveals characteristic feature of macrophage reprogramming in liver Mallory-Denk bodies pathogenesis
Chronic liver diseases are highly linked with mitochondrial dysfunction and macrophage infiltration. Mallory-Denk bodies (...
Increased pro-SFTPB in HDL promotes the pro-inflammatory transition of HDL and represents a sign of poor prognosis in ARDS patients
Increased pro-SFTPB in HDL promotes the pro-inflammatory transition of HDL and represents a sign of poor prognosis in ARDS patients
Acute respiratory distress syndrome (ARDS) is causatively associated with excessive alveolar inflammation involving deregu...
The molecular prognostic scoring system for normal karyotype myelodysplastic syndromes
The molecular prognostic scoring system for normal karyotype myelodysplastic syndromes
Molecular-clinical prognostic models for Myelodysplastic syndromes (MDS) offer more accurate prognosis predictions, yet ex...
PRMT6 promotes colorectal cancer progress via activating MYC signaling
PRMT6 promotes colorectal cancer progress via activating MYC signaling
Colorectal cancer (CRC) remains a major global health challenge, with high rates of incidence and mortality. This study in...
Diagnosis of Parkinson’s disease by eliciting trait-specific eye movements in multi-visual tasks
Diagnosis of Parkinson’s disease by eliciting trait-specific eye movements in multi-visual tasks
Parkinson’s Disease (PD) is a neurodegenerative disorder, and eye movement abnormalities are a significant symptom o...
Development of autonomic innervation at the venous pole of the heart: bridging the gap from mice to human
Development of autonomic innervation at the venous pole of the heart: bridging the gap from mice to human
Prenatal development of autonomic innervation of sinus venosus-related structures might be related to atrial arrhythmias l...
From bench to bedside: future prospects in stem cell therapy for diabetes
From bench to bedside: future prospects in stem cell therapy for diabetes
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4....
A review of the pathogenesis of mitochondria in breast cancer and progress of targeting mitochondria for breast cancer treatment
A review of the pathogenesis of mitochondria in breast cancer and progress of targeting mitochondria for breast cancer treatment
With breast cancer being the most common tumor among women in the world today, it is also the leading cause of cancer-rela...
Amantadine modulates novel macrophage phenotypes to enhance neural repair following spinal cord injury
Amantadine modulates novel macrophage phenotypes to enhance neural repair following spinal cord injury
Spinal cord injury (SCI) triggers a complex inflammatory response that impedes neural repair and functional recovery. The ...
Mfsd2a suppresses colorectal cancer progression and liver metastasis via the S100A14/STAT3 axis
Mfsd2a suppresses colorectal cancer progression and liver metastasis via the S100A14/STAT3 axis
Colorectal cancer (CRC) exhibits a high incidence globally, with the liver being the most common site of distant metastasi...
Engineered T cells secreting αB7-H3-αCD3 bispecific engagers for enhanced anti-tumor activity against B7-H3 positive multiple myeloma: a novel therapeutic approach
Engineered T cells secreting αB7-H3-αCD3 bispecific engagers for enhanced anti-tumor activity against B7-H3 positive multiple myeloma: a novel therapeutic approach
Multiple myeloma (MM) is an incurable plasma cell malignancy with increasing global incidence. Chimeric antigen receptor (...
Autophagy in brain tumors: molecular mechanisms, challenges, and therapeutic opportunities
Autophagy in brain tumors: molecular mechanisms, challenges, and therapeutic opportunities
Autophagy is responsible for maintaining cellular balance and ensuring survival. Autophagy plays a crucial role in the dev...
Possible linking and treatment between Parkinson’s disease and inflammatory bowel disease: a study of Mendelian randomization based on gut–brain axis
Possible linking and treatment between Parkinson’s disease and inflammatory bowel disease: a study of Mendelian randomization based on gut–brain axis
Mounting evidence suggests that Parkinson’s disease (PD) and inflammatory bowel disease (IBD) are closely associated...
Ferroptosis-related genes participate in the microglia-induced neuroinflammation of spinal cord injury via NF-κB signaling: evidence from integrated single-cell and spatial transcriptomic analysis
Ferroptosis-related genes participate in the microglia-induced neuroinflammation of spinal cord injury via NF-κB signaling: evidence from integrated single-cell and spatial transcriptomic analysis
Ferroptosis and immune responses are critical pathological events in spinal cord injury (SCI), whereas relative molecular ...
Molecule interacting with CasL-2 enhances tumor progression and alters radiosensitivity in cervical cancer
Molecule interacting with CasL-2 enhances tumor progression and alters radiosensitivity in cervical cancer
Cervical cancer is a common malignancy among women, and radiotherapy remains a primary treatment modality across all disea...
Hypoxic BMSC-derived exosomal miR-210-3p promotes progression of triple-negative breast cancer cells via NFIX-Wnt/β-catenin signaling axis
Hypoxic BMSC-derived exosomal miR-210-3p promotes progression of triple-negative breast cancer cells via NFIX-Wnt/β-catenin signaling axis
Bone marrow mesenchymal stem cells (BMSCs) are a crucial component of the tumor microenvironment (TME), with hypoxic condi...
Cancer-associated fibroblasts induce almonertinib resistance in non-small cell lung cancer
Cancer-associated fibroblasts induce almonertinib resistance in non-small cell lung cancer
Almonertinib is the initial third-generation EGFR-TKI in China, but its resistance mechanism is unknown. Cancer-associated...
Validity between dual-energy x-ray absorptiometry and bioelectrical impedance for segmental fat analysis and a novel low-cost model developed using anthropometry in young adults
Validity between dual-energy x-ray absorptiometry and bioelectrical impedance for segmental fat analysis and a novel low-cost model developed using anthropometry in young adults
Accurate body fat distribution assessment is essential for managing cardiovascular disease and metabolic disorders. Althou...
Development and validation of a novel coronary artery disease risk prediction model
Development and validation of a novel coronary artery disease risk prediction model
This study aims to develop a novel risk assessment tool for coronary artery disease (CAD) based on data of patients with c...
Deep learning-based prediction of HER2 status and trastuzumab treatment efficacy of gastric adenocarcinoma based on morphological features
Deep learning-based prediction of HER2 status and trastuzumab treatment efficacy of gastric adenocarcinoma based on morphological features
First-line treatment for advanced gastric adenocarcinoma (GAC) with human epidermal growth factor receptor 2 (HER2) is tra...
Safety and efficacy of mesenchymal stromal cells mitochondria transplantation as a cell-free therapy for osteoarthritis
Safety and efficacy of mesenchymal stromal cells mitochondria transplantation as a cell-free therapy for osteoarthritis
The inflammatory responses from synovial fibroblasts and macrophages and the mitochondrial dysfunction in chondrocytes lea...
Unlocking new potential: the evolving landscape of metformin repurposing trials
Unlocking new potential: the evolving landscape of metformin repurposing trials
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4....
Reversal gene expression assessment for drug repurposing, a case study of glioblastoma
Reversal gene expression assessment for drug repurposing, a case study of glioblastoma
Glioblastoma (GBM) is a rare brain cancer with an exceptionally high mortality rate, which illustrates the pressing demand...
Associations between heavy metal exposure and vascular age: a large cross-sectional study
Associations between heavy metal exposure and vascular age: a large cross-sectional study
Heavy metal exposure is an emerging environmental risk factor linked to cardiovascular disease (CVD) through its effects o...
From ex vivo to in vivo chimeric antigen T cells manufacturing: new horizons for CAR T-cell based therapy
From ex vivo to in vivo chimeric antigen T cells manufacturing: new horizons for CAR T-cell based therapy
In the past decades, Chimeric Antigen Receptor (CAR)-T cell therapy has achieved remarkable success, leading to the approv...
Risk analysis of cardiovascular toxicity in patients with lymphoma treated with CD19 CAR T cells
Risk analysis of cardiovascular toxicity in patients with lymphoma treated with CD19 CAR T cells
Anti-CD19 chimeric antigen receptor (CAR) T cell therapy is a common, yet highly efficient, cellular immunotherapy for lym...
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