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Integrating single-nucleus sequence profiling to reveal the transcriptional dynamics of Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis
Integrating single-nucleus sequence profiling to reveal the transcriptional dynamics of Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis
Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS) are three nervous system diseases ...
Proteome-wide mendelian randomization study implicates therapeutic targets in common cancers
Proteome-wide mendelian randomization study implicates therapeutic targets in common cancers
The interest in targeted cancer therapies has been growing rapidly. While numerous cancer biomarkers and targeted treatmen...
Identification of memory B-cell-associated miRNA signature to establish a prognostic model in gastric adenocarcinoma
Identification of memory B-cell-associated miRNA signature to establish a prognostic model in gastric adenocarcinoma
Memory B cells and microRNAs (miRNAs) play important roles in the progression of gastric adenocarcinoma (GAC), also known ...
Neoadjuvant chemotherapy remodels the tumor immune microenvironment by increasing activated and cytotoxic T cell, decreasing B cells and macrophages in small cell lung cancer
Neoadjuvant chemotherapy remodels the tumor immune microenvironment by increasing activated and cytotoxic T cell, decreasing B cells and macrophages in small cell lung cancer
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Sirtuin1, not NAMPT, possesses anti-inflammatory effects in epicardial, pericardial and subcutaneous adipose tissue in patients with CHD
Sirtuin1, not NAMPT, possesses anti-inflammatory effects in epicardial, pericardial and subcutaneous adipose tissue in patients with CHD
Inflammation in cardiac adipose tissue (AT) is associated with atherosclerosis. We investigated whether the epicardial-, p...
SIRT1 activation promotes energy homeostasis and reprograms liver cancer metabolism
SIRT1 activation promotes energy homeostasis and reprograms liver cancer metabolism
Cancer cells are characterized by uncontrolled cell proliferation and impaired bioenergetics. Sirtuins are a family of hig...
Deep dissection of stemness-related hierarchies in hepatocellular carcinoma
Deep dissection of stemness-related hierarchies in hepatocellular carcinoma
Increasing evidence suggests that hepatocellular carcinoma (HCC) stem cells (LCSCs) play an essential part in HCC recurren...
Association of serum 25-hydroxyvitamin D levels with all-cause and cause-specific mortality among postmenopausal females: results from NHANES
Association of serum 25-hydroxyvitamin D levels with all-cause and cause-specific mortality among postmenopausal females: results from NHANES
Vitamin D deficiency is common among the population, but its relationship with mortality of postmenopausal females is uncl...
A novel NET-related gene signature for predicting DLBCL prognosis
A novel NET-related gene signature for predicting DLBCL prognosis
Diffuse large B-cell lymphoma (DLBCL) is an aggressive malignancy. Neutrophil extracellular traps (NETs) are pathogen-trap...
A diagnostic model for sepsis-induced acute lung injury using a consensus machine learning approach and its therapeutic implications
A diagnostic model for sepsis-induced acute lung injury using a consensus machine learning approach and its therapeutic implications
A significant proportion of septic patients with acute lung injury (ALI) are recognized late due to the absence of an effi...
Non-coding RNAs/DNMT3B axis in human cancers: from pathogenesis to clinical significance
Non-coding RNAs/DNMT3B axis in human cancers: from pathogenesis to clinical significance
Cancer is a complex disease with many contributing factors, and researchers have gained extensive knowledge that has helpe...
Association between life’s essential 8 and biological ageing among US adults
Association between life’s essential 8 and biological ageing among US adults
Biological ageing is tightly linked to cardiovascular disease (CVD). We aimed to investigate the relationship between Life...
Predictive performance of triglyceride glucose index (TyG index) to identify glucose status conversion: a 5-year longitudinal cohort study in Chinese pre-diabetes people
Predictive performance of triglyceride glucose index (TyG index) to identify glucose status conversion: a 5-year longitudinal cohort study in Chinese pre-diabetes people
Triglyceride glucose index (TyG index) has been recommended as an alternative indicator of insulin resistance. However, th...
Establishment of a high-fidelity patient-derived xenograft model for cervical cancer enables the evaluation of patient’s response to conventional and novel therapies
Establishment of a high-fidelity patient-derived xenograft model for cervical cancer enables the evaluation of patient’s response to conventional and novel therapies
Recurrent or metastatic cervical cancer (r/m CC) often has poor prognosis owing to its limited treatment options. The deve...
Metastasis organotropism in colorectal cancer: advancing toward innovative therapies
Metastasis organotropism in colorectal cancer: advancing toward innovative therapies
Distant metastasis remains a leading cause of mortality among patients with colorectal cancer (CRC). Organotropism, referr...
CUDC-907, a dual PI3K/histone deacetylase inhibitor, increases meta-iodobenzylguanidine uptake (123/131I-mIBG) in vitro and in vivo: a promising candidate for advancing theranostics in neuroendocrine tumors
CUDC-907, a dual PI3K/histone deacetylase inhibitor, increases meta-iodobenzylguanidine uptake (123/131I-mIBG) in vitro and in vivo: a promising candidate for advancing theranostics in neuroendocrine tumors
Neuroblastoma (NB) and pheochromocytoma/paraganglioma (PHEO/PGL) are neuroendocrine tumors. Imaging of these neoplasms is ...
CD39 and LDHA affects the prognostic role of NLR in metastatic melanoma patients treated with immunotherapy
CD39 and LDHA affects the prognostic role of NLR in metastatic melanoma patients treated with immunotherapy
Identifying response markers is highly needed to guide the treatment strategy in patients with metastatic melanoma. A retr...
Long-term outcomes of offspring from multiple gestations: a two-sample Mendelian randomization study on multi-system diseases using UK Biobank and FinnGen databases
Long-term outcomes of offspring from multiple gestations: a two-sample Mendelian randomization study on multi-system diseases using UK Biobank and FinnGen databases
Assisted reproductive technologies (ART) have increased the incidence of multiple births, which can have a negative impact...
Methods of ex vivo analysis of tissue status in vascularized composite allografts
Methods of ex vivo analysis of tissue status in vascularized composite allografts
Vascularized composite allotransplantation can improve quality of life and restore functionality. However, the complex tis...
Sildenafil, a phosphodiesterase-5 inhibitor, stimulates angiogenesis and bone regeneration in an atrophic non-union model in mice
Sildenafil, a phosphodiesterase-5 inhibitor, stimulates angiogenesis and bone regeneration in an atrophic non-union model in mice
Non-union formation represents a major complication in trauma and orthopedic surgery. The phosphodiesterase-5 (PDE-5) inhi...
Application of radiomics-based multiomics combinations in the tumor microenvironment and cancer prognosis
Application of radiomics-based multiomics combinations in the tumor microenvironment and cancer prognosis
The advent of immunotherapy, a groundbreaking advancement in cancer treatment, has given rise to the prominence of the tum...
Cantharidin induces apoptosis of human triple negative breast cancer cells through mir-607-mediated downregulation of EGFR
Cantharidin induces apoptosis of human triple negative breast cancer cells through mir-607-mediated downregulation of EGFR
Triple negative breast cancer (TNBC) is a major subtype of breast cancer, with limited therapeutic drugs in clinical. Epid...
RAS signaling and immune cells: a sinister crosstalk in the tumor microenvironment
RAS signaling and immune cells: a sinister crosstalk in the tumor microenvironment
The rat sarcoma virus (RAS) gene is the most commonly mutated oncogene in cancer, with about 19% of cancer patients carryi...
Ligand-based adoptive T cell targeting CA125 in ovarian cancer
Ligand-based adoptive T cell targeting CA125 in ovarian cancer
Ovarian cancer (OC) is a highly aggressive gynecological malignancy prevalent worldwide. Most OC cases are typically diagn...
BM-MSCs display altered gene expression profiles in B-cell acute lymphoblastic leukemia niches and exert pro-proliferative effects via overexpression of IFI6
BM-MSCs display altered gene expression profiles in B-cell acute lymphoblastic leukemia niches and exert pro-proliferative effects via overexpression of IFI6
The tumor microenvironment (TME) is a supportive environment responsible for promoting the growth and proliferation of tum...
Osteonecrosis of the jaw induced by immune checkpoint inhibitors: an urgent need for attention
Osteonecrosis of the jaw induced by immune checkpoint inhibitors: an urgent need for attention
Author notesXinya Li and Zaiwei Song contributed equally to this work.Authors and AffiliationsDepartment of Pharmacy, Peki...
Association between 5-year change in cardiovascular risk and the incidence of atherosclerotic cardiovascular diseases: a multi-cohort study
Association between 5-year change in cardiovascular risk and the incidence of atherosclerotic cardiovascular diseases: a multi-cohort study
The influence of the historical cardiovascular risk status on future risk of atherosclerotic cardiovascular disease (ASCVD...
Integrated machine learning survival framework develops a prognostic model based on inter-crosstalk definition of mitochondrial function and cell death patterns in a large multicenter cohort for lower-grade glioma
Integrated machine learning survival framework develops a prognostic model based on inter-crosstalk definition of mitochondrial function and cell death patterns in a large multicenter cohort for lower-grade glioma
Lower-grade glioma (LGG) is a highly heterogeneous disease that presents challenges in accurately predicting patient progn...
STING signaling activation modulates macrophage polarization via CCL2 in radiation-induced lung injury
STING signaling activation modulates macrophage polarization via CCL2 in radiation-induced lung injury
Radiation-induced lung injury (RILI) is a prevalent complication of thoracic radiotherapy in cancer patients. A comprehens...
Interplay of chronic obstructive pulmonary disease and colorectal cancer development: unravelling the mediating role of fatty acids through a comprehensive multi-omics analysis
Interplay of chronic obstructive pulmonary disease and colorectal cancer development: unravelling the mediating role of fatty acids through a comprehensive multi-omics analysis
Chronic obstructive pulmonary disease (COPD) patients often exhibit gastrointestinal symptoms, A potential association bet...
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