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Automating iPSC generation to enable autologous photoreceptor cell replacement therapy
Automating iPSC generation to enable autologous photoreceptor cell replacement therapy
Inherited retinal degeneration is a leading cause of incurable vision loss in the developed world. While autologous iPSC m...
Nanoscale, antigen encounter-dependent, IL-12 delivery by CAR T cells plus PD-L1 blockade for cancer treatment
Nanoscale, antigen encounter-dependent, IL-12 delivery by CAR T cells plus PD-L1 blockade for cancer treatment
Chimeric antigen receptor (CAR)-T cell therapies for the treatment of hematological malignancies experienced tremendous pr...
Identification of MET fusions as novel therapeutic targets sensitive to MET inhibitors in lung cancer
Identification of MET fusions as novel therapeutic targets sensitive to MET inhibitors in lung cancer
Alterations in the MET gene, including amplifications and exon 14 skipping mutations, have been identified as actionable o...
Modeling the enigma of complex disease etiology
Modeling the enigma of complex disease etiology
Complex diseases often present as a diagnosis riddle, further complicated by the combination of multiple phenotypes and di...
Metformin and long non-coding RNAs in breast cancer
Metformin and long non-coding RNAs in breast cancer
Breast cancer (BC) is the second most common cancer and cause of death in women. In recent years many studies investigated...
Precision information extraction for rare disease epidemiology at scale
Precision information extraction for rare disease epidemiology at scale
The United Nations recently made a call to address the challenges of an estimated 300 million persons worldwide living wit...
Lactoferrin suppresses the progression of colon cancer under hyperglycemia by targeting WTAP/m6A/NT5DC3/HKDC1 axis
Lactoferrin suppresses the progression of colon cancer under hyperglycemia by targeting WTAP/m6A/NT5DC3/HKDC1 axis
Although the relationship between type 2 diabetes (T2D) and the increased risk of colorectal carcinogenesis is widely defi...
Very low-calorie ketogenic diet (VLCKD): an antihypertensive nutritional approach
Very low-calorie ketogenic diet (VLCKD): an antihypertensive nutritional approach
Obesity is accompanied by hormonal, inflammatory and endothelial alterations. These alterations induce a stimulation of se...
Characterization of the intestinal fungal microbiome in patients with hepatocellular carcinoma
Characterization of the intestinal fungal microbiome in patients with hepatocellular carcinoma
Gut mycobiota plays a crucial role in benign liver diseases; however, its correlation with hepatocellular carcinoma (HCC) ...
Blockage of glycolysis by targeting PFKFB3 suppresses the development of infantile hemangioma
Blockage of glycolysis by targeting PFKFB3 suppresses the development of infantile hemangioma
Infantile hemangioma (IH) is the most common tumor among infants, but the exact pathogenesis of IH is largely unknown. Our...
Cancer functional states-based molecular subtypes of gastric cancer
Cancer functional states-based molecular subtypes of gastric cancer
The treatment of gastric cancer remains a challenge. We divided gastric cancer into three subtypes based on 14 cancer func...
Sirt3 restricts tumor initiation via promoting LONP1 deacetylation and K63 ubiquitination
Sirt3 restricts tumor initiation via promoting LONP1 deacetylation and K63 ubiquitination
Sirtuin 3 (Sirt3) is a controversial regulator of carcinogenesis. It residents in the mitochondria and gradually decays du...
Loss of miR-26b-5p promotes gastric cancer progression via miR-26b-5p-PDE4B/CDK8-STAT3 feedback loop
Loss of miR-26b-5p promotes gastric cancer progression via miR-26b-5p-PDE4B/CDK8-STAT3 feedback loop
Chronic inflammation is a well-known risk factor for the development of gastric cancer (GC). Nevertheless, the molecular m...
VEGF-A enhances the cytotoxic function of CD4+ cytotoxic T cells via the VEGF-receptor 1/VEGF-receptor 2/AKT/mTOR pathway
VEGF-A enhances the cytotoxic function of CD4+ cytotoxic T cells via the VEGF-receptor 1/VEGF-receptor 2/AKT/mTOR pathway
CD4+ cytotoxic T cells (CD4 CTLs) are CD4+ T cells with major histocompatibility complex-II-restricted cytotoxic function....
Prognostic value of genetic aberrations and tumor immune microenvironment in primary acral melanoma
Prognostic value of genetic aberrations and tumor immune microenvironment in primary acral melanoma
Acral melanoma (AM) is the most common subtype in Chinese melanoma patients with a very poor prognosis. However, our under...