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Clinical outcomes of autologous adipose-derived mesenchymal stem cell combined with high tibial osteotomy for knee osteoarthritis are correlated with stem cell stemness and senescence
Clinical outcomes of autologous adipose-derived mesenchymal stem cell combined with high tibial osteotomy for knee osteoarthritis are correlated with stem cell stemness and senescence
Mesenchymal stem cells (MSCs) have been proposed to treat osteoarthritis (OA) for many years. However, clinical outcomes h...
Tumor microenvironment remodeling after neoadjuvant chemoradiotherapy in local advanced rectal cancer revealed by single-cell RNA sequencing
Tumor microenvironment remodeling after neoadjuvant chemoradiotherapy in local advanced rectal cancer revealed by single-cell RNA sequencing
The use of neoadjuvant chemoradiotherapy (neoCRT) followed by surgery has markedly enhanced the quality of survival in pat...
Microbiome modulators in the treatment of infectious diseases: insights from clinical trials
Microbiome modulators in the treatment of infectious diseases: insights from clinical trials
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4....
Isolation and identification of patient-derived liver cancer stem cells and development of personalized treatment strategies
Isolation and identification of patient-derived liver cancer stem cells and development of personalized treatment strategies
Liver cancer stem cells (LCSCs) are thought to drive the metastasis and recurrence, however, the heterogeneity of molecula...
Correlation between benign prostatic hyperplasia and comorbidities: a systematic analysis integrating global burden of disease and mendelian randomization study
Correlation between benign prostatic hyperplasia and comorbidities: a systematic analysis integrating global burden of disease and mendelian randomization study
Benign prostatic hyperplasia (BPH) is a common chronic condition in elderly men. Observational studies have identified sev...
LRRC8A drives NADPH oxidase-mediated mitochondrial dysfunction and inflammation in allergic rhinitis
LRRC8A drives NADPH oxidase-mediated mitochondrial dysfunction and inflammation in allergic rhinitis
Allergic rhinitis (AR) is a complex disorder with variable pathogenesis. Increasing evidence suggests that the LRRC8A is i...
Towards precision medicine: design considerations for nanozymes in tumor treatment
Towards precision medicine: design considerations for nanozymes in tumor treatment
Since the discovery of Fe3O4 nanoparticles with enzyme-like activity in 2007, nanozymes have emerged as a promising class ...
Multi-omics-driven discovery of invasive patterns and treatment strategies in CA19-9 positive intrahepatic cholangiocarcinoma
Multi-omics-driven discovery of invasive patterns and treatment strategies in CA19-9 positive intrahepatic cholangiocarcinoma
Intrahepatic cholangiocarcinoma (ICC) is a malignant tumor with a poor prognosis, predominantly CA19-9 positive. High CA19...
Modulation of SRC by SNTB1 activates the Hippo-YAP pathway during colon adenocarcinoma metastasis
Modulation of SRC by SNTB1 activates the Hippo-YAP pathway during colon adenocarcinoma metastasis
Colon adenocarcinoma (COAD) ranks as the third most prevalent and lethal cancer in 2020, with metastasis being the primary...
Gut microbial and metabolomics profiles reveal the potential mechanism of fecal microbiota transplantation in modulating the progression of colitis-associated colorectal cancer in mice
Gut microbial and metabolomics profiles reveal the potential mechanism of fecal microbiota transplantation in modulating the progression of colitis-associated colorectal cancer in mice
Intestinal flora promotes the pathogenesis of colorectal cancer (CRC) through microorganisms and their metabolites. This s...
Single-cell transcriptomics link gene expression signatures to clinicopathological features of gonadotroph and lactotroph PitNET
Single-cell transcriptomics link gene expression signatures to clinicopathological features of gonadotroph and lactotroph PitNET
Pituitary neuroendocrine tumors (PitNET) are among the most common intracranial tumors. Despite a frequent benign course, ...
Mendelian randomization analyses support causal relationships between gut microbiome and longevity
Mendelian randomization analyses support causal relationships between gut microbiome and longevity
Gut microbiome plays a significant role in longevity, and dysbiosis is indeed one of the hallmarks of aging. However, the ...
Immunoglobulin-coating patterns reveal altered humoral responses to gut bacteria in pediatric cow milk allergies
Immunoglobulin-coating patterns reveal altered humoral responses to gut bacteria in pediatric cow milk allergies
Pediatric cow milk allergies (CMA) can occur in immunoglobulin (Ig) E and non-IgE-mediated forms. Unlike IgE-mediated alle...
Innovative pan-tumor target strategy for CAR-T therapy: cancer-specific exons as novel targets for pediatric solid and brain tumors
Innovative pan-tumor target strategy for CAR-T therapy: cancer-specific exons as novel targets for pediatric solid and brain tumors
Chimeric antigen receptor T-cell (CAR-T) immunotherapy has achieved remarkable success in treating chemotherapy-refractory...
Single-cell and bulk transcriptome analysis reveals tumor cell heterogeneity and underlying molecular program in uveal melanoma
Single-cell and bulk transcriptome analysis reveals tumor cell heterogeneity and underlying molecular program in uveal melanoma
Uveal melanoma (UM) is a rare and deadly eye cancer with high metastatic potential. Despite the predominance of malignant ...
STAP2 promotes the progression of renal fibrosis via HSP27
STAP2 promotes the progression of renal fibrosis via HSP27
Renal fibrosis is a key process in the progression from acute kidney injury (AKI) to chronic kidney disease (CKD), while t...
Comprehensive analysis of the metabolomics and transcriptomics uncovers the dysregulated network and potential biomarkers of Triple Negative Breast Cancer
Comprehensive analysis of the metabolomics and transcriptomics uncovers the dysregulated network and potential biomarkers of Triple Negative Breast Cancer
Triple-negative breast cancer (TNBC) is known for its aggressive nature, lack of effective diagnostic tools and treatments...
Mitochondrial transplantation following cardiopulmonary resuscitation improves neurological function in rats by inducing M2-type MG/MΦ polarization
Mitochondrial transplantation following cardiopulmonary resuscitation improves neurological function in rats by inducing M2-type MG/MΦ polarization
Explore the effects of mitochondrial transplantation (MT) after cardiopulmonary resuscitation (CPR) on the polarization of...
The Lachnospiraceae-butyric acid axis and its role in glucocorticoid-associated osteonecrosis
The Lachnospiraceae-butyric acid axis and its role in glucocorticoid-associated osteonecrosis
Glucocorticoids (GCs) are key inducers of osteonecrosis, yet not all patients treated with GCs develop glucocorticoid-asso...
From dysfunction to healing: advances in mitochondrial therapy for Osteoarthritis
From dysfunction to healing: advances in mitochondrial therapy for Osteoarthritis
Osteoarthritis (OA) is a chronic degenerative joint condition characterised by cartilage deterioration and changes in bone...
Deletion of MAPL ameliorates septic cardiomyopathy by mitigating mitochondrial dysfunction
Deletion of MAPL ameliorates septic cardiomyopathy by mitigating mitochondrial dysfunction
Mitochondrial dysfunction is a critical factor in the pathogenesis of septic cardiomyopathy (SCM). Mitochondrial anchored ...
Shedding of membrane complement inhibitors CD59 and CD46 into the circulation is associated with poor prognosis in acute coronary syndrome patients: a cohort study
Shedding of membrane complement inhibitors CD59 and CD46 into the circulation is associated with poor prognosis in acute coronary syndrome patients: a cohort study
The role of the complement inhibitory proteins CD46 and CD59 in the immune response to an acute coronary syndrome (ACS) is...
Single cell analysis identified a basal cell transition state associated with the development and progression of bladder cancer
Single cell analysis identified a basal cell transition state associated with the development and progression of bladder cancer
Bladder cancer (BC) is a prevalent malignancy characterized by significant cellular heterogeneity. While single-cell multi...
Adipose-derived stem cell exosomal miR-21-5p enhances angiogenesis in endothelial progenitor cells to promote bone repair via the NOTCH1/DLL4/VEGFA signaling pathway
Adipose-derived stem cell exosomal miR-21-5p enhances angiogenesis in endothelial progenitor cells to promote bone repair via the NOTCH1/DLL4/VEGFA signaling pathway
Angiogenesis is essential for repairing critical-sized bone defects. Although adipose-derived stem cell (ADSC)-derived exo...
Advancing cancer research through organoid technology
Advancing cancer research through organoid technology
The complexity of tumors and the challenges associated with treatment often stem from the limitations of existing models i...
Clinical trial landscape for TIL therapy: emerging insights and future directions in oncology
Clinical trial landscape for TIL therapy: emerging insights and future directions in oncology
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4....
Cross-sectional study on the diagnostic significance of plasma exosomal miRNAs in HBV-related hepatocellular carcinoma
Cross-sectional study on the diagnostic significance of plasma exosomal miRNAs in HBV-related hepatocellular carcinoma
Hepatocellular carcinoma (HCC) associated with Hepatitis B Virus (HBV) is one of the most severe malignancies in East Asia...
Etrinabdione (VCE-004.8), a B55α activator, promotes angiogenesis and arteriogenesis in critical limb ischemia
Etrinabdione (VCE-004.8), a B55α activator, promotes angiogenesis and arteriogenesis in critical limb ischemia
Vasculogenic therapies explored for the treatment of peripheral artery disease (PAD) have encountered minimal success in c...
Letter: The risk-benefit balance of CRISPR-Cas screening systems in gene editing and targeted cancer therapy
Letter: The risk-benefit balance of CRISPR-Cas screening systems in gene editing and targeted cancer therapy
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4....
SLC38A5 suppresses ferroptosis through glutamine-mediated activation of the PI3K/AKT/mTOR signaling in osteosarcoma
SLC38A5 suppresses ferroptosis through glutamine-mediated activation of the PI3K/AKT/mTOR signaling in osteosarcoma
Solute carrier family 38 member 5 (SLC38A5) is an amino acid transporter that plays a significant role in various cellular...
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