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Valproic acid inhibits cell growth in both MCF-7 and MDA-MB231 cells by triggering different responses in a cell type-specific manner
Valproic acid inhibits cell growth in both MCF-7 and MDA-MB231 cells by triggering different responses in a cell type-specific manner
Breast cancer is the second leading cause of death among women after lung cancer. Despite the improvement in prevention an...
CD206+ tumor-associated macrophages interact with CD4+ tumor-infiltrating lymphocytes and predict adverse patient outcome in human laryngeal squamous cell carcinoma
CD206+ tumor-associated macrophages interact with CD4+ tumor-infiltrating lymphocytes and predict adverse patient outcome in human laryngeal squamous cell carcinoma
Tumor-associated macrophages (TAMs) are major component in the tumor microenvironment (TME) and play regulatory role in tu...
Automating iPSC generation to enable autologous photoreceptor cell replacement therapy
Automating iPSC generation to enable autologous photoreceptor cell replacement therapy
Inherited retinal degeneration is a leading cause of incurable vision loss in the developed world. While autologous iPSC m...
Nanoscale, antigen encounter-dependent, IL-12 delivery by CAR T cells plus PD-L1 blockade for cancer treatment
Nanoscale, antigen encounter-dependent, IL-12 delivery by CAR T cells plus PD-L1 blockade for cancer treatment
Chimeric antigen receptor (CAR)-T cell therapies for the treatment of hematological malignancies experienced tremendous pr...
Expanding the phenome and variome of the ROBO-SLIT pathway in congenital heart defects: toward improving the genetic testing yield of CHD
Expanding the phenome and variome of the ROBO-SLIT pathway in congenital heart defects: toward improving the genetic testing yield of CHD
Recent studies have shown the implication of the ROBO-SLIT pathway in heart development. Within this study, we aimed to fu...
Identification of MET fusions as novel therapeutic targets sensitive to MET inhibitors in lung cancer
Identification of MET fusions as novel therapeutic targets sensitive to MET inhibitors in lung cancer
Alterations in the MET gene, including amplifications and exon 14 skipping mutations, have been identified as actionable o...
Modeling the enigma of complex disease etiology
Modeling the enigma of complex disease etiology
Complex diseases often present as a diagnosis riddle, further complicated by the combination of multiple phenotypes and di...
Metformin and long non-coding RNAs in breast cancer
Metformin and long non-coding RNAs in breast cancer
Breast cancer (BC) is the second most common cancer and cause of death in women. In recent years many studies investigated...
Precision information extraction for rare disease epidemiology at scale
Precision information extraction for rare disease epidemiology at scale
The United Nations recently made a call to address the challenges of an estimated 300 million persons worldwide living wit...
Lactoferrin suppresses the progression of colon cancer under hyperglycemia by targeting WTAP/m6A/NT5DC3/HKDC1 axis
Lactoferrin suppresses the progression of colon cancer under hyperglycemia by targeting WTAP/m6A/NT5DC3/HKDC1 axis
Although the relationship between type 2 diabetes (T2D) and the increased risk of colorectal carcinogenesis is widely defi...
Very low-calorie ketogenic diet (VLCKD): an antihypertensive nutritional approach
Very low-calorie ketogenic diet (VLCKD): an antihypertensive nutritional approach
Obesity is accompanied by hormonal, inflammatory and endothelial alterations. These alterations induce a stimulation of se...
Association of milk consumption with all-cause mortality and cardiovascular outcomes: a UK Biobank based large population cohort study
Association of milk consumption with all-cause mortality and cardiovascular outcomes: a UK Biobank based large population cohort study
The association of milk consumption with mortality and cardiovascular disease (CVD) outcomes was unclear. The present stud...
Anti-oncogenic effects of dutasteride, a dual 5-alpha reductase inhibitor and a drug for benign prostate hyperplasia, in bladder cancer
Anti-oncogenic effects of dutasteride, a dual 5-alpha reductase inhibitor and a drug for benign prostate hyperplasia, in bladder cancer
The incidence of bladder cancer (BCa) is approximately four times higher in men than in women. To develop effective BCa tr...
Safety and efficacy of first-in-man intrathecal injection of human astrocytes (AstroRx®) in ALS patients: phase I/IIa clinical trial results
Safety and efficacy of first-in-man intrathecal injection of human astrocytes (AstroRx®) in ALS patients: phase I/IIa clinical trial results
Malfunction of astrocytes is implicated as one of the pathological factors of ALS. Thus, intrathecal injection of healthy ...
Characterization of the intestinal fungal microbiome in patients with hepatocellular carcinoma
Characterization of the intestinal fungal microbiome in patients with hepatocellular carcinoma
Gut mycobiota plays a crucial role in benign liver diseases; however, its correlation with hepatocellular carcinoma (HCC) ...
HDAC inhibitor ITF2357 reduces resistance of mutant-KRAS non-small cell lung cancer to pemetrexed through a HDAC2/miR-130a-3p-dependent mechanism
HDAC inhibitor ITF2357 reduces resistance of mutant-KRAS non-small cell lung cancer to pemetrexed through a HDAC2/miR-130a-3p-dependent mechanism
Histone deacetylases (HDAC) contribute to oncogenic program, pointing to their inhibitors as a potential strategy against ...
Tumor-associated macrophages and Tregs influence and represent immune cell infiltration of muscle-invasive bladder cancer and predict prognosis
Tumor-associated macrophages and Tregs influence and represent immune cell infiltration of muscle-invasive bladder cancer and predict prognosis
Muscle-invasive urothelial bladder cancer (MIBC) is associated with limited response rates to systemic therapy, risk of re...
Genome-wide polygenic risk score for major osteoporotic fractures in postmenopausal women using associated single nucleotide polymorphisms
Genome-wide polygenic risk score for major osteoporotic fractures in postmenopausal women using associated single nucleotide polymorphisms
Osteoporosis is highly polygenic and heritable, with heritability ranging from 50 to 80%; most inherited susceptibility is...
Young and undamaged recombinant albumin alleviates T2DM by improving hepatic glycolysis through EGFR and protecting islet β cells in mice
Young and undamaged recombinant albumin alleviates T2DM by improving hepatic glycolysis through EGFR and protecting islet β cells in mice
Albumin is the most abundant protein in serum and serves as a transporter of free fatty acids (FFA) in blood vessels. In t...
Bi-anti therapy for SARS-CoV-2 infection among mild/moderate patients to prevent coronavirus disease 2019 from progressing to severe disease
Bi-anti therapy for SARS-CoV-2 infection among mild/moderate patients to prevent coronavirus disease 2019 from progressing to severe disease
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whic...
Associations of types of grains and lifestyle with all-cause mortality among Chinese adults aged 65 years or older: a prospective cohort study
Associations of types of grains and lifestyle with all-cause mortality among Chinese adults aged 65 years or older: a prospective cohort study
Little is known on the association of types of grains with mortality and the moderating effect of lifestyle on this associ...
Transcriptomics-proteomics Integration reveals alternative polyadenylation driving inflammation-related protein translation in patients with diabetic nephropathy
Transcriptomics-proteomics Integration reveals alternative polyadenylation driving inflammation-related protein translation in patients with diabetic nephropathy
Diabetic nephropathy (DN) is a complex disease involving the upregulation of many inflammation-related proteins. Alternati...
Blockage of glycolysis by targeting PFKFB3 suppresses the development of infantile hemangioma
Blockage of glycolysis by targeting PFKFB3 suppresses the development of infantile hemangioma
Infantile hemangioma (IH) is the most common tumor among infants, but the exact pathogenesis of IH is largely unknown. Our...
Cancer functional states-based molecular subtypes of gastric cancer
Cancer functional states-based molecular subtypes of gastric cancer
The treatment of gastric cancer remains a challenge. We divided gastric cancer into three subtypes based on 14 cancer func...
Sirt3 restricts tumor initiation via promoting LONP1 deacetylation and K63 ubiquitination
Sirt3 restricts tumor initiation via promoting LONP1 deacetylation and K63 ubiquitination
Sirtuin 3 (Sirt3) is a controversial regulator of carcinogenesis. It residents in the mitochondria and gradually decays du...
Loss of miR-26b-5p promotes gastric cancer progression via miR-26b-5p-PDE4B/CDK8-STAT3 feedback loop
Loss of miR-26b-5p promotes gastric cancer progression via miR-26b-5p-PDE4B/CDK8-STAT3 feedback loop
Chronic inflammation is a well-known risk factor for the development of gastric cancer (GC). Nevertheless, the molecular m...
Clinical impact of volume of disease and time of metastatic disease presentation on patients receiving enzalutamide or abiraterone acetate plus prednisone as first-line therapy for metastatic castration-resistant prostate cancer
Clinical impact of volume of disease and time of metastatic disease presentation on patients receiving enzalutamide or abiraterone acetate plus prednisone as first-line therapy for metastatic castration-resistant prostate cancer
Metastatic castration-resistant prostate cancer remains a challenging condition to treat. Among the available therapeutic ...
VEGF-A enhances the cytotoxic function of CD4+ cytotoxic T cells via the VEGF-receptor 1/VEGF-receptor 2/AKT/mTOR pathway
VEGF-A enhances the cytotoxic function of CD4+ cytotoxic T cells via the VEGF-receptor 1/VEGF-receptor 2/AKT/mTOR pathway
CD4+ cytotoxic T cells (CD4 CTLs) are CD4+ T cells with major histocompatibility complex-II-restricted cytotoxic function....
Prognostic value of the pretreatment systemic immune-inflammation index in patients with prostate cancer: a systematic review and meta-analysis
Prognostic value of the pretreatment systemic immune-inflammation index in patients with prostate cancer: a systematic review and meta-analysis
The systemic immune-inflammation index (SII) is a novel biomarker to predict the prognosis of some malignant tumors based ...
Prognostic value of genetic aberrations and tumor immune microenvironment in primary acral melanoma
Prognostic value of genetic aberrations and tumor immune microenvironment in primary acral melanoma
Acral melanoma (AM) is the most common subtype in Chinese melanoma patients with a very poor prognosis. However, our under...
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