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Circadian rhythm disruption modulates enteric neural precursor cells differentiation leading to gastrointestinal motility dysfunction via the NR1D1/NF-κB axis
Circadian rhythm disruption modulates enteric neural precursor cells differentiation leading to gastrointestinal motility dysfunction via the NR1D1/NF-κB axis
Circadian rhythm disruption (CRD) is implicated with numerous gastrointestinal motility diseases, with the enteric nervous...
Genetic susceptibility to caffeine intake and metabolism: a systematic review
Genetic susceptibility to caffeine intake and metabolism: a systematic review
Coffee and tea consumption account for most caffeine intake and 2–3 billion cups are taken daily around the world. C...
Microplastics: an often-overlooked issue in the transition from chronic inflammation to cancer
Microplastics: an often-overlooked issue in the transition from chronic inflammation to cancer
The presence of microplastics within the human body has raised significant concerns about their potential health implicati...
Low PD-L1 expression, MAP2K2 alterations, and enriched HPV gene signatures characterize brain metastases in head and neck squamous cell carcinoma
Low PD-L1 expression, MAP2K2 alterations, and enriched HPV gene signatures characterize brain metastases in head and neck squamous cell carcinoma
Brain metastasis (BM) is a rare but severe complication of head and neck squamous cell carcinoma (HNSCC), with limited kno...
Weight loss, changes in body composition and inflammatory status after a very low-energy ketogenic therapy (VLEKT): does gender matter?
Weight loss, changes in body composition and inflammatory status after a very low-energy ketogenic therapy (VLEKT): does gender matter?
Considering differences in body composition and inflammatory status between sexes, as well as recent recommendations advoc...
Integrative multi-omics analysis reveals the role of tumor-associated endothelial cells and their signature in prognosis of intrahepatic cholangiocarcinoma
Integrative multi-omics analysis reveals the role of tumor-associated endothelial cells and their signature in prognosis of intrahepatic cholangiocarcinoma
This study aims to investigate the interplay between tumor-associated endothelial cells (TECs) and immune cells within the...
Endothelial extracellular vesicles: their possible function and clinical significance in diabetic vascular complications
Endothelial extracellular vesicles: their possible function and clinical significance in diabetic vascular complications
Diabetic vascular complications attract increased attention due to their high morbidity, mortality and disability rate. Co...
STYK1 mediates NK cell anti-tumor response through regulating CCR2 and trafficking
STYK1 mediates NK cell anti-tumor response through regulating CCR2 and trafficking
The serine/threonine/tyrosine kinase 1 (STYK1) is a receptor protein-tyrosine kinase (RPTK)-like molecule that is detected...
Parvimonas micra forms a distinct bacterial network with oral pathobionts in colorectal cancer patients
Parvimonas micra forms a distinct bacterial network with oral pathobionts in colorectal cancer patients
Mounting evidence suggests a significant role of the gut microbiota in the development and progression of colorectal cance...
Multi-omics insights into the microbiota-gut-brain axis and cognitive improvement post-bariatric surgery
Multi-omics insights into the microbiota-gut-brain axis and cognitive improvement post-bariatric surgery
Although numerous studies have shown that bariatric surgery results in sustained weight loss and modifications in gut micr...
3D biological scaffold delivers Bergenin to reduce neuroinflammation in rats with cerebral hemorrhage
3D biological scaffold delivers Bergenin to reduce neuroinflammation in rats with cerebral hemorrhage
Intracerebral hemorrhage (ICH) is a severe form of stroke characterized by high incidence and mortality rates. Currently, ...
Comprehensive biomarker and modeling approach to support dose finding for BI 836880, a VEGF/Ang-2 inhibitor
Comprehensive biomarker and modeling approach to support dose finding for BI 836880, a VEGF/Ang-2 inhibitor
BI 836880 is a humanized bispecific nanobody® that binds to and blocks vascular endothelial growth factor (VEGF) and ...
Mitochondrial transplantation: a promising strategy for treating degenerative joint diseases
Mitochondrial transplantation: a promising strategy for treating degenerative joint diseases
The prevalence of age-related degenerative joint diseases, particularly intervertebral disc degeneration and osteoarthriti...
Influence of the gut microbiota on immune cell interactions and cancer treatment
Influence of the gut microbiota on immune cell interactions and cancer treatment
The tumour microenvironment represents a novel frontier in oncological research. Over the past decade, accumulating eviden...
Dual-labeled anti-GD2 targeted probe for intraoperative molecular imaging of neuroblastoma
Dual-labeled anti-GD2 targeted probe for intraoperative molecular imaging of neuroblastoma
Surgical resection is integral for the treatment of neuroblastoma, the most common extracranial solid malignancy in childr...
Differential methylation of circulating free DNA assessed through cfMeDiP as a new tool for breast cancer diagnosis and detection of BRCA1/2 mutation
Differential methylation of circulating free DNA assessed through cfMeDiP as a new tool for breast cancer diagnosis and detection of BRCA1/2 mutation
Recent studies have highlighted the importance of the cell-free DNA (cfDNA) methylation profile in detecting breast cancer...
Radiotherapy enhances the anti-tumor effect of CAR-NK cells for hepatocellular carcinoma
Radiotherapy enhances the anti-tumor effect of CAR-NK cells for hepatocellular carcinoma
Chimeric antigen receptor (CAR)-NK cell therapy has shown remarkable clinical efficacy and safety in the treatment of hema...
Cancer cell-selective induction of mitochondrial stress and immunogenic cell death by PT-112 in human prostate cell lines
Cancer cell-selective induction of mitochondrial stress and immunogenic cell death by PT-112 in human prostate cell lines
PT-112 is a novel immunogenic cell death (ICD)-inducing small molecule currently under Phase 2 clinical development, inclu...
Immunometabolic changes and potential biomarkers in CFS peripheral immune cells revealed by single-cell RNA sequencing
Immunometabolic changes and potential biomarkers in CFS peripheral immune cells revealed by single-cell RNA sequencing
The pathogenesis of Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) remains unclear, though increasing evidenc...
Letter to the Editor: Is Omeprazole a contributing risk factor for osteoarthritis (OA)?
Letter to the Editor: Is Omeprazole a contributing risk factor for osteoarthritis (OA)?
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4....
KLF4 regulates trophoblast function and associates with unexplained recurrent spontaneous abortion
KLF4 regulates trophoblast function and associates with unexplained recurrent spontaneous abortion
Recurrent spontaneous abortion (RSA) is defined as two or more consecutive spontaneous abortions before 20 weeks ...
KLF14 directly downregulates the expression of GPX4 to exert antitumor effects by promoting ferroptosis in cervical cancer
KLF14 directly downregulates the expression of GPX4 to exert antitumor effects by promoting ferroptosis in cervical cancer
Cervical cancer is the fourth leading cause of cancer-related death among women worldwide, and effective therapeutic strat...
Is adjuvant immunotherapy necessary after neoadjuvant chemoimmunotherapy in NSCLC? A propensity score matching analysis
Is adjuvant immunotherapy necessary after neoadjuvant chemoimmunotherapy in NSCLC? A propensity score matching analysis
Before matching, no significant differences were observed between the two groups regarding gender, smoking history, BMI, p...
Homeobox B9 promotes the invasion and metastasis of hepatocellular carcinoma cells via the EZH2–MIR203A–SNAI2 axis
Homeobox B9 promotes the invasion and metastasis of hepatocellular carcinoma cells via the EZH2–MIR203A–SNAI2 axis
Research has elucidated that homeobox B9 (HOXB9), an important transcriptional activator, plays a pivotal role in promotin...
A genetically informed study reveals modifiable pathways in skin cancer
A genetically informed study reveals modifiable pathways in skin cancer
Identifying modifiable risk factors is essential for the prevention of skin cancer; however, establishing causality can be...
Targeting the gut microbiota: a new strategy for colorectal cancer treatment
Targeting the gut microbiota: a new strategy for colorectal cancer treatment
How to reduce the high incidence rate and mortality of colorectal cancer (CRC) effectively is the focus of current researc...
HNRNPC modulates PKM alternative splicing via m6A methylation, upregulating PKM2 expression to promote aerobic glycolysis in papillary thyroid carcinoma and drive malignant progression
HNRNPC modulates PKM alternative splicing via m6A methylation, upregulating PKM2 expression to promote aerobic glycolysis in papillary thyroid carcinoma and drive malignant progression
The heterogeneous nuclear ribonucleoprotein C (HNRNPC) plays a crucial role in tumorigenesis, yet its role in papillary th...
Monocyte subsets in breast cancer patients under treatment with aromatase inhibitor and mucin-1 cancer vaccine
Monocyte subsets in breast cancer patients under treatment with aromatase inhibitor and mucin-1 cancer vaccine
Monocytes comprise subsets of classical, intermediate and non-classical monocytes with distinct anti- or pro-tumor effects...
Spatial analyses revealed S100P + TFF1 + tumor cells in spread through air spaces samples correlated with undesirable therapy response in non-small cell lung cancer
Spatial analyses revealed S100P + TFF1 + tumor cells in spread through air spaces samples correlated with undesirable therapy response in non-small cell lung cancer
Spread through air spaces (STAS) is a recognized aggressive pattern in lung cancer, serving as a crucial risk factor for p...
Interferon regulatory factor 7 alleviates the experimental colitis through enhancing IL-28A-mediated intestinal epithelial integrity
Interferon regulatory factor 7 alleviates the experimental colitis through enhancing IL-28A-mediated intestinal epithelial integrity
The incidence of inflammatory bowel disease (IBD) is on the rise in developing countries, and investigating the underlying...
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