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Role of periodontal ligament fibroblasts in periodontitis: pathological mechanisms and therapeutic potential
Role of periodontal ligament fibroblasts in periodontitis: pathological mechanisms and therapeutic potential
Periodontal ligament fibroblasts (PDLFs) play a crucial role in the etiology of periodontitis and periodontal tissue regen...
Disruption of gamete fusion alters the sperm-egg ratio at gamete interaction
Disruption of gamete fusion alters the sperm-egg ratio at gamete interaction
The mechanisms enabling sperm to locate unfertilized eggs within the fallopian tubes remain a subject of debate in reprodu...
Unraveling the interplay of CD8 + T cells and microRNA signaling in cancer: implications for immune dysfunction and therapeutic approaches
Unraveling the interplay of CD8 + T cells and microRNA signaling in cancer: implications for immune dysfunction and therapeutic approaches
MicroRNAs (miRNAs) emerge as critical regulators of CD8 + T cell function within the complex tumor microenviro...
Microbial and proteomic signatures of type 2 diabetes in an Arab population
Microbial and proteomic signatures of type 2 diabetes in an Arab population
The rising prevalence of Type 2 diabetes mellitus (T2D) in the Qatari population presents a significant public health chal...
Accurate and cost-effective generation of a genetic risk score direct from blood lysates
Accurate and cost-effective generation of a genetic risk score direct from blood lysates
Ethics approval and consent to participate This study was c...
Denosumab in osteoporosis management for diabetes patients: insights from clinical trials and explorations for dual benefit
Denosumab in osteoporosis management for diabetes patients: insights from clinical trials and explorations for dual benefit
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4....
EBV-induced upregulation of CD55 reduces the efficacy of cetuximab treatment in nasopharyngeal carcinoma
EBV-induced upregulation of CD55 reduces the efficacy of cetuximab treatment in nasopharyngeal carcinoma
Cetuximab, an anti-epidermal growth factor receptor (EGFR) antibody, has been shown to improve survival in nasopharyngeal ...
Gender differences in dietary patterns and physical activity: an insight with principal component analysis (PCA)
Gender differences in dietary patterns and physical activity: an insight with principal component analysis (PCA)
Gender differences in dietary patterns and physical activity are known to influence metabolic health, but research explori...
A CT-based subregional radiomics nomogram for predicting local recurrence-free survival in esophageal squamous cell cancer patients treated by definitive chemoradiotherapy: a multicenter study
A CT-based subregional radiomics nomogram for predicting local recurrence-free survival in esophageal squamous cell cancer patients treated by definitive chemoradiotherapy: a multicenter study
To develop and validate an online individualized model for predicting local recurrence-free survival (LRFS) in esophageal ...
A review of the complex interplay between chemoresistance and lncRNAs in lung cancer
A review of the complex interplay between chemoresistance and lncRNAs in lung cancer
Lung Cancer (LC) is characterized by chemoresistance, which poses a significant clinical challenge and results in a poor p...
High tumor mutational burden assessed through next-generation sequencing predicts favorable survival in microsatellite stable metastatic colon cancer patients
High tumor mutational burden assessed through next-generation sequencing predicts favorable survival in microsatellite stable metastatic colon cancer patients
Microsatellite instability (MSI) is a well-established predictive biomarker for immune checkpoint inhibitor (ICI) response...
Integrative analysis of multi-omics data identified PLG as key gene related to Anoikis resistance and immune phenotypes in hepatocellular carcinoma
Integrative analysis of multi-omics data identified PLG as key gene related to Anoikis resistance and immune phenotypes in hepatocellular carcinoma
The extracellular matrix (ECM) plays a pivotal role in the initiation and progression of hepatocellular carcinoma (HCC) by...
A decade of incremental advances in radiopharmaceuticals: a promising future ahead
A decade of incremental advances in radiopharmaceuticals: a promising future ahead
To evaluate global trends, we analyzed RDC-related clinical trials using the Informa Database (https://pharma.id.informa.c...
Early introduction of IL-10 weakens BCG revaccination’s protection by suppressing CD4+Th1 cell responses
Early introduction of IL-10 weakens BCG revaccination’s protection by suppressing CD4+Th1 cell responses
The Bacillus Calmette-Guérin (BCG) vaccine, currently the sole authorized vaccine against tuberculosis (TB), demonstr...
Genomic and clinical characterization of pediatric lymphoepithelioma-like carcinoma
Genomic and clinical characterization of pediatric lymphoepithelioma-like carcinoma
Pediatric lymphoepithelioma-like carcinoma (pLELC) is a rare neoplasm with unclear prognosis, genome, and tumor microenvir...
Depleting parenchymal border macrophages alleviates cerebral edema and neuroinflammation following status epilepticus
Depleting parenchymal border macrophages alleviates cerebral edema and neuroinflammation following status epilepticus
Status epilepticus (SE) is a common severe neurological emergency. Cerebral edema caused by SE is unavoidable and may exac...
Study on the application of microfluidic-based in vitro diagnostic technology in pathogenic detection of respiratory tract infections
Study on the application of microfluidic-based in vitro diagnostic technology in pathogenic detection of respiratory tract infections
To investigate the clinical application value of microfluidic-based in vitro diagnostic (IVD) technology in pathogenic det...
SULT2B1: a novel therapeutic target in colorectal cancer via modulation of AKT/PKM2-mediated glycolysis and proliferation
SULT2B1: a novel therapeutic target in colorectal cancer via modulation of AKT/PKM2-mediated glycolysis and proliferation
Sulfotransferase family 2B member 1 (SULT2B1) is involved in regulating cell proliferation, migration and metabolism. Howe...
Safety and therapeutic potential of allogeneic adipose-derived stem cell spray transplantation in ischemic cardiomyopathy: a phase I clinical trial
Safety and therapeutic potential of allogeneic adipose-derived stem cell spray transplantation in ischemic cardiomyopathy: a phase I clinical trial
Ischemic cardiomyopathy, characterized by coronary artery atherosclerosis, impairs the myocardial tissue. Coronary artery ...
Combining immunoscore and tumor budding in colon cancer: an insightful prognostication based on the tumor-host interface
Combining immunoscore and tumor budding in colon cancer: an insightful prognostication based on the tumor-host interface
Tumor Budding (TB) and Immunoscore are independent prognostic markers in colon cancer (CC). Given their respective represe...
Impact of daily fasting duration on body composition and cardiometabolic risk factors during a time-restricted eating protocol: a randomized controlled trial
Impact of daily fasting duration on body composition and cardiometabolic risk factors during a time-restricted eating protocol: a randomized controlled trial
Time-restricted eating (TRE) is a dietary regimen that limits food intake for at least 12 h daily. Unlike other f...
Cholesterol overload in macrophages drives metabolic dysfunction-associated steatohepatitis via inhibiting 7-dehydrocholesterol reductase in mice
Cholesterol overload in macrophages drives metabolic dysfunction-associated steatohepatitis via inhibiting 7-dehydrocholesterol reductase in mice
Dietary cholesterol promotes metabolic dysfunction-associated steatohepatitis (MASH), with hepatic macrophages central to ...
Use of phase angle as an indicator of overtraining in sport and physical training
Use of phase angle as an indicator of overtraining in sport and physical training
The use of bioelectrical impedance analysis (BIA) is now well established in healthcare as an essential support tool for p...
Association of radiomic features with genomic signatures in thyroid cancer: a systematic review
Association of radiomic features with genomic signatures in thyroid cancer: a systematic review
There is a growing interest on the association of radiomic features with genomic signatures in oncology. Using computation...
Clinical trial landscape for histone deacetylation inhibitors in breast cancer: a dawn in the darkness?
Clinical trial landscape for histone deacetylation inhibitors in breast cancer: a dawn in the darkness?
Breast cancer (BRCA) is a highly malignant solid tumor with poor prognosis and a high mortality rate among woman worldwide...
CAR-armored-cell therapy in solid tumor treatment
CAR-armored-cell therapy in solid tumor treatment
Over the past decade, chimeric antigen receptor (CAR)-T cell therapy has emerged as a revolutionary immunotherapeutic appr...
Inhibition of the E3 ligase UBR5 stabilizes TERT and protects vascular organoids from oxidative stress
Inhibition of the E3 ligase UBR5 stabilizes TERT and protects vascular organoids from oxidative stress
Excessive oxidative stress is known to cause endothelial dysfunction and drive cardiovascular diseases (CVD). While telome...
Right ventricular volume overload reboots cardiomyocyte proliferation via immune responses
Right ventricular volume overload reboots cardiomyocyte proliferation via immune responses
Right ventricular volume overload (RVVO) is one of the most important hemodynamic characteristics in children with congeni...
Monitoring circulating tumor DNA liquid biopsy in stage III BRAF-mutant melanoma patients undergoing adjuvant treatment
Monitoring circulating tumor DNA liquid biopsy in stage III BRAF-mutant melanoma patients undergoing adjuvant treatment
The introduction of adjuvant therapies for patients with resected cutaneous melanoma (CM) has increased the need for sensi...
Ion channels research in hPSC-RPE cells: bridging benchwork to clinical applications
Ion channels research in hPSC-RPE cells: bridging benchwork to clinical applications
Ion channels in retinal pigment epithelial (RPE) cells are crucial for retinal health and vision functions. Defects in suc...
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