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Chronotherapeutic intervention targeting emotion regulation brain circuitry, symptoms, and suicide risk in adolescents and young adults with bipolar disorder: a pilot randomised trial
BackgroundBipolar disorder (BD) is characterised by pronounced emotion dysregulation associated with depressive and (hypo)...
A qualitative study exploring the feasibility and acceptability of computerised adaptive testing to assess and monitor children and young peoples mental health in primary care settings in the UK
WHAT IS ALREADY KNOWN ON THIS TOPICAn increasing number of children and young people (CYP) are struggling with mental heal...
Will things feel better in the morning? A time-of-day analysis of mental health and wellbeing from nearly 1 million observations
IntroductionMental health and well-being (MHW) is dynamic in nature. A large and growing body of research has shown that M...
Digital sleep phenotype and wrist actigraphy in individuals at clinical high risk for psychosis and people with schizophrenia spectrum disorders: a systematic review and meta-analysis
WHAT IS ALREADY KNOWN ON THIS TOPICSleep abnormalities are common in individuals at clinical high risk for psychosis (CHR-...
Minimally important change on the Columbia Impairment Scale and Strengths and Difficulties Questionnaire in youths seeking mental healthcare
WHAT IS ALREADY KNOWN ON THIS TOPICMinimally important change (MIC) thresholds determine the smallest amount of change cap...
Comparing apples and oranges in youth depression treatments? A quantitative critique of the evidence base and guidelines
WHAT IS ALREADY KNOWN ON THIS TOPICPsychotherapy is recommended before medication for most cases of depression in children...
Cost-utility of behavioural activation for mitigating psychological impacts of COVID-19 on socially isolated older adults with depression and multiple long-term conditions compared with usual care: results from a pragmatic randomised controlled trial
BackgroundDepression comorbid with multiple (two or more) long-term conditions (MLTCs) is a pressing public health challen...
Multigenerational family coaggregation study of obsessive-compulsive disorder and cardiometabolic disorders
WHAT IS ALREADY KNOWN ON THIS TOPICObsessive-compulsive disorder (OCD) is associated with an increased risk of morbidity a...
Prognostic models for depression and post-traumatic stress disorder symptoms following traumatic brain injury: a CENTER-TBI study
WHAT IS ALREADY KNOWN ON THIS TOPICHOW THIS STUDY MIGHT AFFECT RESEARCH, PRACTICE OR POLICYIntroductionTraumatic brain inj...
Eco-anxiety, climate change and the 'bottom billion: a plea for better understanding
How common is eco-anxiety in the Global South?Anthropogenic (human-caused) climate change poses an enormous, rapidly incre...
Maternal perinatal anxiety and infant primary care use in 1998-2016: a UK cohort study
WHAT IS ALREADY KNOWN ON THIS TOPICTo date, there has been no large UK study assessing/identifying the relationship direct...
Ethnic disparities in rapid tranquillisation use and justifications in adult mental health inpatient settings: a systematic review and meta-analysis
BackgroundEthnicity is frequently reported as a risk factor associated with rapid tranquillisation (RT) use in mental heal...
Do coping mechanisms moderate the effect of stressful life events on depression and anxiety in young people? A case-control study from Latin America
WHAT IS ALREADY KNOWN ON THIS TOPICStressful life events can increase the risk of experiencing mental health problems. By ...
Exploring the minimal important difference in the treatment of paediatric obsessive-compulsive disorder using selective serotonin reuptake inhibitors
BackgroundThe Children’s Yale-Brown Obsessive-Compulsive Scale (CYBOCS) is a clinician rated instrument developed to quant...
Acceptability, use and safety of the BlueIce self-harm prevention app: qualitative findings from the Beating Adolescent Self-Harm (BASH) randomised controlled trial
WHAT IS ALREADY KNOWN ON THIS TOPICAround one in four children and young people under the age of 18 will self-harm.Most se...
Exploring early discontinuation of mental health outpatient treatment: language, demographics and clinical characteristics among migrant populations in Japan
IntroductionAs the rate of migrant population in Japan and globally is growing, so are the needs of mental health treatmen...
Prioritised research questions in serious mental illness: a priority setting based on evidence gaps
BackgroundIn 2021, the Swedish Agency for Health Technology Assessment and Assessment of Social Services (SBU) published a...
Parkinsons disease psychosis associated with accelerated multidomain cognitive decline
WHAT IS ALREADY KNOWN ON THIS TOPICCognitive impairments in patients with Parkinson’s disease (PD) psychosis are associate...
Brighter future for light therapy: harmonising the reporting of light interventions in psychiatry
The use of light for therapeutic purposes dates back millennia. Light therapy, as a possible treatment for seasonal affect...
Chronotype and emotion processing: a pilot study testing timing of online cognitive bias modification training
WHAT IS ALREADY KNOWN ON THE TOPICSynchrony effects (better performance at a time-of-day that is aligned to individual chr...
Efficacy, acceptability and tolerability of second-generation antipsychotics for behavioural and psychological symptoms of dementia: a systematic review and network meta-analysis
WHAT IS ALREADY KNOWN ON THIS TOPICWHAT THIS STUDY ADDSThe present study provides the first updated evidence to determine ...
Potential dopaminergic deficit in patients with geriatric psychiatric disorders as revealed by DAT-SPECT: a cross-sectional study
WHAT IS ALREADY KNOWN ON THIS TOPICIt has been reported that patients with geriatric psychiatric disorders include cases i...
'Theres more to life than staring at a small screen: a mixed methods cohort study of problematic smartphone use and the relationship to anxiety, depression and sleep in students aged 13-16 years old in the UK
Theme 1: effects on relationshipsTwenty-one respondents mentioned that smartphone use had an impact on their relationships...
Psychological well-being and needs of parents and carers of children and young people with mental health difficulties: a quantitative systematic review with meta-analyses
BackgroundMany mental health difficulties, including anxiety disorders, obsessive compulsive disorder (OCD), eating disord...
Severe psychiatric disorders are associated with increased risk of dementia
WHAT IS ALREADY KNOWN ON THIS TOPICSevere mental illness has been shown to increase the risk of dementia in later life. Th...
Paediatric traumatic brain injury and attention-deficit/hyperactivity disorder medication in Finland: a nationwide register-based cohort study
BackgroundA traumatic brain injury (TBI) is characterised by a disruption of normal brain function or structure caused by ...
Changes in the prevalence of mental health problems during the first year of the pandemic: a systematic review and dose-response meta-analysis
IntroductionMental health is a major public health concern.1 Mental health conditions have long been and still are underdi...
Hypersexuality in neurological disorders: A systematic review
WHAT IS ALREADY KNOWN ON THIS TOPICHypersexuality is an understudied behavioural complication across neurological conditio...
Mortality and adverse events associated with statin use in primary care patients with depression: a real-world, population-based cohort study
BackgroundStatins are a class of cholesterol-lowering drugs licensed for the prevention and treatment of cardiovascular an...
Experiences and impact of psychiatric inpatient admissions far away from home: a qualitative study with young people, parents/carers and healthcare professionals
WHAT IS ALREADY KNOWN ON THIS TOPICService demand for inpatient care sometimes results in young people (YP) being admitted...
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