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Shionone Relieves LPS-Induced Acute Lung Injury by Regulating the TNIP2/NF-kB Pathway
Shionone Relieves LPS-Induced Acute Lung Injury by Regulating the TNIP2/NF-kB Pathway
Acute lung injury, a diffuse inflammatory injury caused by various factors, is characterized by respiratory distress and p...
Insights into the Composition of Breu Canauaru, an Enigmatic Medicinal “Resin” from Amazonia
Insights into the Composition of Breu Canauaru, an Enigmatic Medicinal “Resin” from Amazonia
Breu canauaru is well-known in the Brazilian Amazon for its purported medicinal and magical properties, but its origin has...
Baicalein: Multiple Pharmacological Activities, Pharmacokinetics, and Clinical Trials
Baicalein: Multiple Pharmacological Activities, Pharmacokinetics, and Clinical Trials
Baicalein, a flavone present in various plants, has gained widespread recognition for its variety of health benefits. It e...
Detecting Phytoestrogens and Mammalian Estrogens in Blackcurrants (Ribes nigrum)
Detecting Phytoestrogens and Mammalian Estrogens in Blackcurrants (Ribes nigrum)
Phytoestrogens are estrogen-like compounds found in various plants. Menopausal women experience various menopausal symptom...
α-Pyrones: Natural Occurrence, Chemistry, and Biological Approaches—An Update
α-Pyrones: Natural Occurrence, Chemistry, and Biological Approaches—An Update
α-Pyrones are naturally occurring unsaturated lactones with promising bioactivities, such as antimicrobial, cytotoxic...
Safety and Efficacy of Geraniol in Gastrointestinal System
Safety and Efficacy of Geraniol in Gastrointestinal System
Geraniol, a naturally occurring acyclic isoprenoid, is found in the volatile oils of plants like lemongrass and rose. It i...
Gastroprotective and Ulcer Healing Effects of Lonchocarpus sericeus Seed Extract in Rodents
Gastroprotective and Ulcer Healing Effects of Lonchocarpus sericeus Seed Extract in Rodents
Lonchocarpus sericeus (Poir.) Kunth ex DC., Fabaceae, is traditionally used to treat stomach disorders and constipation. P...
Encapsulating Epigallocatechin-3-Gallate (EGCG) in Chitosan Nanoparticles Influenced Multiple Genes Controlling Oncostatic Signaling Pathways in HepG2 Cells
Encapsulating Epigallocatechin-3-Gallate (EGCG) in Chitosan Nanoparticles Influenced Multiple Genes Controlling Oncostatic Signaling Pathways in HepG2 Cells
The primary polyphenol in green tea, epigallocatechin-3-gallate (EGCG), is the primary active polyphenol in green tea that...
Matricin Modulates Carbamazepine-Induced Acute Tubulointerstitial Nephritis in Rat Models of Alzheimer’s Disease via MEK-JAK2-STAT3 Signaling
Matricin Modulates Carbamazepine-Induced Acute Tubulointerstitial Nephritis in Rat Models of Alzheimer’s Disease via MEK-JAK2-STAT3 Signaling
Carbamazepine is a first-choice anticonvulsant, and its medication is typically well tolerated when compared to lithium an...
Chemical Profiling and Antioxidant Activity of Extracts from Kalanchoe Medicinal Species: Intraspecific Sources of Variation in Kalanchoe crenata and K. pinnata
Chemical Profiling and Antioxidant Activity of Extracts from Kalanchoe Medicinal Species: Intraspecific Sources of Variation in Kalanchoe crenata and K. pinnata
Kalanchoe crenata (Andrews) Haw., and K. pinnata (Lam.) Pers., Crassulaceae, both popularly known as saião or courama...
The Use of Natural Products in the Treatment of Sickle Cell Disease
The Use of Natural Products in the Treatment of Sickle Cell Disease
Sickle cell disease is the world's leading inherited genetic hemoglobinopathy, originating from African peoples, chara...
Comparative Plant Metabolomics of Momordica charantia Seeds and Fruits
Comparative Plant Metabolomics of Momordica charantia Seeds and Fruits
Momordica charantia L., Cucurbitaceae, known mainly as karela, bitter gourd or bitter melon, and balsam pear, is used for ...
Chemical and Biological Aspects of Solanum paniculatum Roots
Chemical and Biological Aspects of Solanum paniculatum Roots
Here we report the most complete study of a plant used for culinary and medicinal purposes. This study was conducted with ...
Investigation of the Antinociceptive and Gastroprotective Potential of the Flavonoid Tricin and its Possible Mechanism of Action
Investigation of the Antinociceptive and Gastroprotective Potential of the Flavonoid Tricin and its Possible Mechanism of Action
Tricin is a flavonoid that occurs in monocotyledonous plants and exhibits a broad pharmacological spectrum, including anti...
Anti-elastase, Anti-tyrosinase, and Anti-inflammatory Activities of Three Compounds Isolated from Psorospermum aurantiacum: In Silico and In Vitro Assays
Anti-elastase, Anti-tyrosinase, and Anti-inflammatory Activities of Three Compounds Isolated from Psorospermum aurantiacum: In Silico and In Vitro Assays
The hexane fraction of Psorospermum aurantiacum Engl., Hypericaceae, was found to prevent photo aging in skin cells lines....
Chemodiversity and Trypanocidal Activity of the Volatile Oils of Tropical Black Sage
Chemodiversity and Trypanocidal Activity of the Volatile Oils of Tropical Black Sage
Tropical black sage (Varronia curassavica Jacq., Cordiaceae) is a species native to ecosystems subject to strong anthropic...
Recycling Preparative Liquid Chromatography, the Overlooked Methodology for the Purification of Natural Products
Recycling Preparative Liquid Chromatography, the Overlooked Methodology for the Purification of Natural Products
Frequently, preparative high-performance liquid chromatography separations of complex natural product mixtures by adsorpti...
Anti-inflammatory and Antioxidant Activity of Eugenial D from Eugenia astringens
Anti-inflammatory and Antioxidant Activity of Eugenial D from Eugenia astringens
Eugenia astringens Cambess. (syn. Eugenia umbelliflora O.Berg), Myrtaceae, is a plant widely used in the Brazilian traditi...
Antibacterial Activity and AbFtsZ Binding Properties of Fungal Metabolites Isolated from Mexican Mangroves
Antibacterial Activity and AbFtsZ Binding Properties of Fungal Metabolites Isolated from Mexican Mangroves
Antimicrobial resistance is emerging as a global health challenge that requires immediate and concerted attention. Accordi...
Molluscicidal Activity of Piper anisum Volatile Oil and of its Major Chemical Marker, 1-Butyl-3,4-methylenedioxybenzene
Molluscicidal Activity of Piper anisum Volatile Oil and of its Major Chemical Marker, 1-Butyl-3,4-methylenedioxybenzene
Schistosomiasis, a disease endemic to Brazil, is caused by the trematode Schistosoma mansoni, which uses Biomphalaria glab...
Aqueous Extract and Solvent Fractions of Hancornia speciosa Fruits, Rutin, and Chlorogenic Acid Attenuate the Edema, Inflammation, and Myonecrosis Caused by Bothrops jararaca Snake Venom in Mice
Aqueous Extract and Solvent Fractions of Hancornia speciosa Fruits, Rutin, and Chlorogenic Acid Attenuate the Edema, Inflammation, and Myonecrosis Caused by Bothrops jararaca Snake Venom in Mice
Snakebites are considered a neglected tropical disease in Brazil and 70% of cases of envenomation are attributed to the ge...
Protective Effects of Paeoniflorin Against Inflammation and Oxidative Stress in Rats with Gestational Diabetes Mellitus via Inhibiting the RhoA/ROCK Signaling Pathway
Protective Effects of Paeoniflorin Against Inflammation and Oxidative Stress in Rats with Gestational Diabetes Mellitus via Inhibiting the RhoA/ROCK Signaling Pathway
Gestational diabetes mellitus is a condition of glucose intolerance that occurs only in pregnant women. Paeoniflorin was r...
Resveratrol Improves Mechanical Allodynia and Inflammation: Focus on Sex Differences in Rats
Resveratrol Improves Mechanical Allodynia and Inflammation: Focus on Sex Differences in Rats
Inflammatory pain is a complex phenomenon arising from various etiological factors, resulting in diverse symptoms that can...
Anti HSV-1 Activity of Cistus laurifolius and Development of Antiviral Herbal Lip Balm
Anti HSV-1 Activity of Cistus laurifolius and Development of Antiviral Herbal Lip Balm
Cistus laurifolius L., Cistaceae, has long been used for traditional treatments against various skin diseases in Turkey. T...
Nitric Oxide Inhibitors from the Stem Bark of Biancaea decapetala: An In Vitro and In Silico Study
Nitric Oxide Inhibitors from the Stem Bark of Biancaea decapetala: An In Vitro and In Silico Study
This study presents the anti-inflammatory potential of compounds isolated from the stem bark of Biancaea decapetala (Roth)...
Anti-inflammatory, Radical-Scavenging, and Chelating Activities of Nor-Triterpenes from Galphimia Species
Anti-inflammatory, Radical-Scavenging, and Chelating Activities of Nor-Triterpenes from Galphimia Species
Anti-inflammatory and radical-scavenging activities of the methanolic extract from the leaves of Galphimia spp. collected ...
Antiviral Activity of Withanolide A Against Different Infectivity Phases of Dengue Virus Serotype 2 in Vero Cell Line
Antiviral Activity of Withanolide A Against Different Infectivity Phases of Dengue Virus Serotype 2 in Vero Cell Line
Dengue fever is caused by the Aedes mosquito-borne dengue virus, which is a global threat with 400 million cases reported ...
Synthesis of Myrtucommulone D: A Selective Inhibitor of Tyrosyl-DNA Phosphodiesterase 2 Promoting Drug Resistance Reversal in Lung Cancer Cells
Synthesis of Myrtucommulone D: A Selective Inhibitor of Tyrosyl-DNA Phosphodiesterase 2 Promoting Drug Resistance Reversal in Lung Cancer Cells
Chemoresistance has emerged as a critical barrier in the treatment of lung cancer. The recently discovered DNA repair enzy...
Isoflavone-Rich Extract of Trifolium resupinatum: Anti-obesity Attributes with In Silico Investigation of Its Constituents
Isoflavone-Rich Extract of Trifolium resupinatum: Anti-obesity Attributes with In Silico Investigation of Its Constituents
Trifolium resupinatum L., Fabaceae, aqueous methanol leaf extract was selected to mitigate some obesity-associated risk fa...
Deciphering the Antidiarrheal Mechanisms of Macleaya cordata by Combining Network Pharmacology, Molecular Docking, and Experimental Evaluations
Deciphering the Antidiarrheal Mechanisms of Macleaya cordata by Combining Network Pharmacology, Molecular Docking, and Experimental Evaluations
Diarrhea continues to be a major public health problem and is thought to be the cause of 525,000 child fatalities annually...
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