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Repurposing of Plasmodium falciparum var genes beyond the blood stage
Volume 70, December 2022, 102207Highlights•Plasmodium genomes harbor variant multigene families with diverse functions.•Im...
Escherichia coli bacteria associated with Crohn’s disease persist within phagolysosomes
Crohn’s disease (CD) is characterized by an imbalance of intestinal microbiota and a colonization of subepithelial tissues...
Targeting Helicobacter pylori for antibacterial drug discovery with novel therapeutics
Volume 70, December 2022, 102203Helicobacter pylori is an important human pathogen with increasing antimicrobial resistanc...
Beyond splicing: serine–arginine proteins as emerging multifaceted regulators of RNA metabolism in malaria parasites
Volume 70, December 2022, 102201The serine–arginine-rich (SR) proteins play an exceptionally important role in eukaryotic ...
Ubiquitin and ubiquitin-like conjugation systems in trypanosomatids
Volume 70, December 2022, 102202Highlights•Ubiquitination and ubiquitin-like modification regulates trypanosomatid differe...
Diversity, detection and exploitation: linking soil fungi and plant disease
Volume 70, December 2022, 102199Highlights•Plant-associated fungi in the rhizosphere are incredibly diverse.•High plant di...
Use of pharmacokinetic/pharmacodynamic approaches for dose optimization: a case study of plazomicin
Volume 70, December 2022, 102204Highlights•Pharmacokinetics/pharmacodynamics of plazomicin has been characterized across a...
Editorial overview: current state and future of the microbiome field: why context matters
Prof Lindsay Hall is Chair of Intestinal Microbiome at the Technical University of Munich since 2020. She also holds a Gro...
Progress and opportunities in microbial community metabolomics
Volume 70, December 2022, 102195Highlights•Microbiome-associated metabolite pools aid discovery of novel functions.•Guilt-...
Within-host evolution of bacterial pathogens during persistent infection of humans
Volume 70, December 2022, 102197Highlights•Some persistent infections are linked to drug resistance and adverse outcomes s...
From genome structure to function: insights into structural variation in microbiology
Volume 69, October 2022, 102192Highlights•Bacteria can adapt to environmental fluctuations through genome rearrangement.•I...
Antifungal discovery
Volume 69, October 2022, 102198Highlights•Fungi have a serious impact on human health, causing millions of deaths worldwid...
Post-translational lipid modifications in Plasmodium parasites
Volume 69, October 2022, 102196Highlights•Lipidation can modulate protein function by increasing affinity to membranes.•Ma...
Plasmodium falciparum resistance to artemisinin-based combination therapies
Volume 69, October 2022, 102193Highlights•Mutant K13-mediated artemisinin resistance involves reduced hemoglobin endocytos...
Culturomics, a potential approach paving the way toward bacteriotherapy
Volume 69, October 2022, 102194The human microbiota has been extensively studied over the past decade to describe its role...
Bottlenecks and opportunities in antibiotic discovery against Mycobacterium tuberculosis
Volume 69, October 2022, 102191Highlights•“Old” molecules and targets represent attractive start points.•Modern medicinal ...
A brief guide to machine learning for antibiotic discovery
Volume 69, October 2022, 102190Highlights•Rising antibiotic resistance requires novel approaches to antibiotic discovery.•...
How did we get here? Insights into mechanisms of immunity-related GTPase targeting to intracellular pathogens
Volume 69, October 2022, 102189Highlights•Immunity-related GTPases (IRGs) specifically localize to and destroy pathogen-co...
Making sense of drug-efflux transporters in the physiological environment
Volume 69, October 2022, 102179Highlights•RND pumps of P. aeruginosa and A. baumannii, fall into three different categorie...
A genomic journey in the secondary metabolite diversity of fungal plant and insect pathogens: from functional to population genomics
Volume 69, October 2022, 102178Highlights•Pathogenic fungi produce secondary metabolites (SMs) to control the host and its...
Fungal endophytes in plants and their relationship to plant disease
Volume 69, October 2022, 102177Highlights•True endophytic fungi (EF) are organisms inside plants never causing disease.•Fu...
Metarhizium: an opportunistic middleman for multitrophic lifestyles
Volume 69, October 2022, 102176Highlights•Metarhizium are major models for studying virulence evolution (host switching an...
Bacterial photosynthesis: state-of-the-art in light-driven carbon fixation in engineered bacteria
Volume 69, October 2022, 102174Highlights•Light-driven carbon fixation shows great potential in reducing carbon emissions....
Mother–infant transmission of human microbiota
Volume 69, October 2022, 102173Humans are colonised by a highly adapted microbiota with coevolved functions that promote h...
Toward merging bottom–up and top–down model-based designing of synthetic microbial communities
Volume 69, October 2022, 102169Highlights•Analysis and designing of microbiomes have become a new paradigm in microbiology...
Editorial overview: Eco-evolutionary dynamics in microbiology comes of age
John Bruce is a postdoctoral researcher in the Hoskisson lab at the University of Strathclyde. His work has previously foc...
Microbiome engineering for sustainable agriculture: using synthetic biology to enhance nitrogen metabolism in plant-associated microbes
Volume 68, August 2022, 102172Highlights•Plant–microbe interactions are central to sustainable agriculture.•Nitrogen metab...
Advances in constraint-based models: methods for improved predictive power based on resource allocation constraints
Volume 68, August 2022, 102168The concept of metabolic models with resource allocation constraints has been around for ove...
Synthetic microbiology applications powered by light
Volume 68, August 2022, 102158Highlights•Synthetic biological devices can help solve societal issues.•Optogenetics combine...