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A novel selenium nanocomposite modified by AANL inhibits tumor growth by upregulating CLK2 in lung cancer
A novel selenium nanocomposite modified by AANL inhibits tumor growth by upregulating CLK2 in lung cancer
Lung cancer is a primary malignant tumor originating from the bronchial mucosal epithelium with high mortality, accounting...
Design, synthesis and evaluation of thieno[3,2-d]pyrimidine derivatives as novel potent CDK7 inhibitors
Design, synthesis and evaluation of thieno[3,2-d]pyrimidine derivatives as novel potent CDK7 inhibitors
The constitutive activation of mitogenic signaling and cell cycle progression, as well as the addiction to oncogenic trans...
Novel trifluoromethyl ketone derivatives as oral cPLA2/COX-2 dual inhibitors for resolution of inflammation in rheumatoid arthritis
Novel trifluoromethyl ketone derivatives as oral cPLA2/COX-2 dual inhibitors for resolution of inflammation in rheumatoid arthritis
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disorder influenced by genetic and environmental risk facto...
Synthesis, evaluation of biological activity and SAR of new thioalkyl derivatives of pyridine
Synthesis, evaluation of biological activity and SAR of new thioalkyl derivatives of pyridine
One of the most important goal of synthetic organic chemistry is to develop methods for the synthesis of multifunctional c...
Synthesis of triazole AD-1 derivatives and its mechanism of mediating DNA damage of ROS in lung cancer cells
Synthesis of triazole AD-1 derivatives and its mechanism of mediating DNA damage of ROS in lung cancer cells
In recent years, due to the influence of many factors such as environment, eating habits, stress and so on, cancer may exc...
Diaminocyclopentane – l-Lysine Adducts: Potent and selective inhibitors of human O-GlcNAcase
Diaminocyclopentane – l-Lysine Adducts: Potent and selective inhibitors of human O-GlcNAcase
A new class of compounds, namely highly substituted diaminocyclopentane-l-lysine adducts, have been discovered as potent i...
A review of chemical signaling mechanisms underlying quorum sensing and its inhibition in Staphylococcus aureus
A review of chemical signaling mechanisms underlying quorum sensing and its inhibition in Staphylococcus aureus
Staphylococcus aureus is a prominent worldwide infectious agent that leads to a significant and complicated in assessing t...
Discovery of novel biphenyl derivatives as androgen receptor degraders for the treatment of enzalutamide-resistant prostate cancer
Discovery of novel biphenyl derivatives as androgen receptor degraders for the treatment of enzalutamide-resistant prostate cancer
Prostate cancer (PCa) is the second most common cancer and the fifth leading cause of cancer-related deaths in men worldwi...
Discovery of a first-in-class degrader for the protein arginine methyltransferase 6 (PRMT6)
Discovery of a first-in-class degrader for the protein arginine methyltransferase 6 (PRMT6)
Epigenetic events include DNA methylation, histone modifications, chromatin remodeling, and the influence of noncoding RNA...
Unique aminothiazolyl coumarins as potential DNA and membrane disruptors towards Enterococcus faecalis
Unique aminothiazolyl coumarins as potential DNA and membrane disruptors towards Enterococcus faecalis
The serious antibiotic-resistance crisis has penetrated the consciousness of medicinal researchers and clinicians [1], [2]...
Novel quinazolin-2-yl 1,2,3-triazole hybrids as promising multi-target anticancer agents: Design, synthesis, and molecular docking study
Novel quinazolin-2-yl 1,2,3-triazole hybrids as promising multi-target anticancer agents: Design, synthesis, and molecular docking study
The global burden of cancer is substantial and growing, with an estimated 20 million new cases and 10 million deaths from ...
Synthesis, kinetic studies, and QSAR of dinucleoside polyphosphate derivatives as human AK1 inhibitors
Synthesis, kinetic studies, and QSAR of dinucleoside polyphosphate derivatives as human AK1 inhibitors
Adenylate kinase (AK) plays a crucial role in the metabolic monitoring of cellular adenine nucleotide homeostasis by catal...
Synthesis and in vitro antitumor evaluation of new thieno[2,3-d]pyrimidine derivatives as EGFR and DHFR inhibitors
Synthesis and in vitro antitumor evaluation of new thieno[2,3-d]pyrimidine derivatives as EGFR and DHFR inhibitors
Cancer is ranked as the second cause of death globally [1]. The incidence of cancer cases is predicted to reach 37 million...
Design, synthesis and biological evaluation of new RNF126-based p300/CBP degraders
Design, synthesis and biological evaluation of new RNF126-based p300/CBP degraders
The histone acetyltransferase CREB-binding protein (CBP) and its cognate protein p300 are key activators of transcription ...
Synthesis, design, and antiproliferative evaluation of 6-(N-Substituted-methyl)pyrazolo[3,4-d]pyrimidines as the potent anti-leukemia agents
Synthesis, design, and antiproliferative evaluation of 6-(N-Substituted-methyl)pyrazolo[3,4-d]pyrimidines as the potent anti-leukemia agents
Cancer is characterized by abnormal cell proliferation and has become an important global health issue in recent years [1]...
Discovery of selective TYK2 inhibitors: Design, synthesis, in vitro and in silico studies of promising hits with triazolopyrimidinone scaffold
Discovery of selective TYK2 inhibitors: Design, synthesis, in vitro and in silico studies of promising hits with triazolopyrimidinone scaffold
The JAK enzyme family is a member of the JAK-STAT (Janus Kinase − Signal Transducer and Activator Transcription) signaling...
Dauresorcinols A and B, two pairs of merosesquiterpenoid enantiomers with new carbon skeletons from Rhododendron dauricum
Dauresorcinols A and B, two pairs of merosesquiterpenoid enantiomers with new carbon skeletons from Rhododendron dauricum
With the development of society and changes in human lifestyles and eating patterns, type 2 diabetes mellitus (T2DM) has b...
Spectroscopic, biochemical and computational studies of bioactive DNA minor groove binders targeting 5′-WGWWCW-3′ motif
Spectroscopic, biochemical and computational studies of bioactive DNA minor groove binders targeting 5′-WGWWCW-3′ motif
Sequence-specific molecular recognition of the minor groove in double-helical DNA by low molecular weight, aromatic peptid...
Taking advantage of the interaction between the sulfoxide and heme cofactor to develop indoleamine 2, 3-dioxygenase 1 inhibitors
Taking advantage of the interaction between the sulfoxide and heme cofactor to develop indoleamine 2, 3-dioxygenase 1 inhibitors
Tryptophan-kynurenine metabolism plays an important role in the regulation of immune response, neuronal function and intes...
Utility of sulfachloropyridazine in the synthesis of novel anticancer agents as antiangiogenic and apoptotic inducers
Utility of sulfachloropyridazine in the synthesis of novel anticancer agents as antiangiogenic and apoptotic inducers
Renal cell carcinoma (RCC) is considered an aggressive malignancy of the genitourinary tract with poor prognosis particula...
A FRET-based multifunctional fluorescence probe for the simultaneous detection of sulfite and viscosity in living cells
A FRET-based multifunctional fluorescence probe for the simultaneous detection of sulfite and viscosity in living cells
Endoplasmic reticulum (ER), a organelle with the largest membrane structure in the organism, is the main site of protein s...
Synthesis of obovatol and related neolignan analogues as α-glucosidase and α-amylase inhibitors
Synthesis of obovatol and related neolignan analogues as α-glucosidase and α-amylase inhibitors
Diabetes mellitus is a metabolic disease characterized by hyperglycemia, which can be counteracted by the inhibition of α-...
Synthesis of novel indol-3-acetamido analogues as potent anticancer agents, biological evaluation and molecular modeling studies
Synthesis of novel indol-3-acetamido analogues as potent anticancer agents, biological evaluation and molecular modeling studies
Synthetic cannabinoids are part of a group of drugs called new psychoactive substances (NPS) exhibiting their pharmacologi...