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Peptide Nucleic Acids: Recent Developments in the Synthesis and Backbone Modifications
Peptide Nucleic Acids: Recent Developments in the Synthesis and Backbone Modifications
Nucleic acids (DNA/RNA) are the biopolymers that provide the fundamental basis for life's intricate cellular processes. Th...
Discovery of a minimalistic DIE-based fluorescent probe for detection of parallel G-quadruplex forms
Discovery of a minimalistic DIE-based fluorescent probe for detection of parallel G-quadruplex forms
Volume 141, December 2023, 106879Author links open overlay panel, AbstractG-quadruplexes (G4s) are considered to be involv...
13C NMR-based dereplication using MixONat software to decipher potent anti-cholinesterase compounds in Mesua lepidota bark
13C NMR-based dereplication using MixONat software to decipher potent anti-cholinesterase compounds in Mesua lepidota bark
Alzheimer’s disease (AD) is a devastating neurodegenerative disorder that accounts for more than 80% of age-related dement...
Pyrimidine-morpholine hybrids as potent druggable therapeutics for Alzheimer’s disease: Synthesis, biochemical and in silico analyses
Pyrimidine-morpholine hybrids as potent druggable therapeutics for Alzheimer’s disease: Synthesis, biochemical and in silico analyses
Alzheimer’s disease (AD) is a chronic neurological disorder that influence many parts of the body including central nervou...
A near-infrared fluorescent probe with remarkably large stokes shift for specifical imaging of peroxynitrite fluctuations in Hela cells
A near-infrared fluorescent probe with remarkably large stokes shift for specifical imaging of peroxynitrite fluctuations in Hela cells
Alzheimer’s disease, a common neurodegenerative disease, involves the progressive and gradual decline in cognitive functio...
Derivative of cinnamic acid inhibits T3SS of Xanthomonas oryzae pv. oryzae through the HrpG-HrpX regulatory cascade
Derivative of cinnamic acid inhibits T3SS of Xanthomonas oryzae pv. oryzae through the HrpG-HrpX regulatory cascade
Bacterial leaf blight (BLB) is a devastating worldwide rice disease caused by the pathogen Xanthomonas oryzae pv. oryzae (...
Indoloquinazoline alkaloids suppress angiogenesis and inhibit metastasis of melanoma cells
Indoloquinazoline alkaloids suppress angiogenesis and inhibit metastasis of melanoma cells
Angiogenesis plays a crucial role to provide oxygen and nutrients by multistep process for the development and growth of s...
In vitro and in vivo anticancer activity of novel Rh(III) and Pd(II) complexes with pyrazolopyrimidine derivatives
In vitro and in vivo anticancer activity of novel Rh(III) and Pd(II) complexes with pyrazolopyrimidine derivatives
Cancer has become one of the main causes of disease death, which is caused by the abnormal proliferation of cells that gro...
Fluoroalkoxylated C-3 and C-9 (S)-12-bromostepholidine analogues with D1R antagonist activity
Fluoroalkoxylated C-3 and C-9 (S)-12-bromostepholidine analogues with D1R antagonist activity
There are 5 dopamine (DA) receptor subtypes (D1R-D5R) and these are broadly divided into two main families: D1-like (compr...
Structural diversity and biological activities of indole-diterpenoids from Penicillium janthinellum by co-culture with Paecilomyces formosus
Structural diversity and biological activities of indole-diterpenoids from Penicillium janthinellum by co-culture with Paecilomyces formosus
Fungi, with a conservative estimate of over 2.2 million species, are widely distributed in nature, only 7% of which have b...
Combination of quinoxaline with pentamethinium system: Mitochondrial staining and targeting
Combination of quinoxaline with pentamethinium system: Mitochondrial staining and targeting
Dedicated to Dr. Tomáš Bříza, who first prepared both pentamethinium salts with quinoxaline substitutionKeywordsPentamethi...
Protecting-group free synthesis of glycoconjugates displaying dual fungicidal and plant defense-eliciting activities
Protecting-group free synthesis of glycoconjugates displaying dual fungicidal and plant defense-eliciting activities
Carbohydrates and their conjugates play key roles in many vital functions. They not only represent chemical scaffolds for ...
Design, synthesis, biological evaluation, and docking study of new triazole-phenylacetamide derivatives as α-glucosidase inhibitors
Design, synthesis, biological evaluation, and docking study of new triazole-phenylacetamide derivatives as α-glucosidase inhibitors
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease that is represented by persistent high blood glucose levels...
Exploration of the novel phthalimide-hydroxypyridinone derivatives as multifunctional drug candidates against Alzheimer’s disease
Exploration of the novel phthalimide-hydroxypyridinone derivatives as multifunctional drug candidates against Alzheimer’s disease
Alzheimer's disease (AD) is a neurodegenerative disease that occurs more commonly in the elderly, often manifesting sympto...
Potential natural product 3,4-seco-schitriterpenoids from Kadsura japonica L. as anti-neuroinflammatory agents
Potential natural product 3,4-seco-schitriterpenoids from Kadsura japonica L. as anti-neuroinflammatory agents
Kadsura japonica L., a flowering evergreen tropic and sub-tropic climbing plant, is native to Japan and can be found in Ta...
Peripheral substitution effects on unnatural base pairs: A case of brominated TPT3 to enhance replication fidelity
Peripheral substitution effects on unnatural base pairs: A case of brominated TPT3 to enhance replication fidelity
In most organisms on earth, from bacteria to humans, they share four natural genetic alphabets A/T/G/C. However, the limit...
Selective degradation of BRD4 suppresses lung cancer cell proliferation using GSH-responsive PROTAC precursors
Selective degradation of BRD4 suppresses lung cancer cell proliferation using GSH-responsive PROTAC precursors
Bromodomain containing protein 4 (BRD4), a transcriptional and epigenetic regulator, plays an essential role in cell survi...
Cyclometalated iridium(III) complexes induce immunogenic cell death in HepG2 cells via paraptosis
Cyclometalated iridium(III) complexes induce immunogenic cell death in HepG2 cells via paraptosis
In the field of cancer therapy, the harnessing of the immune system to combat cancer is increasingly being evaluated as a ...
11,12-seco-Abietane-type diterpene lactones with potential antiplatelet activity from Salvia prattii
11,12-seco-Abietane-type diterpene lactones with potential antiplatelet activity from Salvia prattii
Platelets are an essential cell fragment in physiological hemostasis [1]. However, platelet activation and aggregation in ...