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Elevated nuclear PIGL disrupts the cMyc/BRD4 axis and improves PD-1 blockade therapy by dampening tumor immune evasion
Elevated nuclear PIGL disrupts the cMyc/BRD4 axis and improves PD-1 blockade therapy by dampening tumor immune evasion
To improve the efficacy of lenvatinib in combination with programmed death-1 (PD-1) blockade therapy for hepatoce...
PI4P STimulatING innate immune activation: beyond the Golgi
PI4P STimulatING innate immune activation: beyond the Golgi
Fang R, Jiang Q, Jia X, Jiang Z. ARMH3-mediated recruitment of PI4KB directs Golgi-to-endosome trafficking and activation ...
Biomechanical control of lymphatic vessel physiology and functions
Biomechanical control of lymphatic vessel physiology and functions
The ever-growing research on lymphatic biology has clearly identified lymphatic vessels as key players that maintain human...
Cullin 4B-RING E3 ligase complex in immune cell differentiation and function
Cullin 4B-RING E3 ligase complex in immune cell differentiation and function
Li Y, Wang X. The role of cullin4B in human cancers. Exp Hematol Oncol. 2017;6:17.Article  PubMed  PubMed Central ...
Macrophage phagocytosis of SARS-CoV-2-infected cells mediates potent plasmacytoid dendritic cell activation
Macrophage phagocytosis of SARS-CoV-2-infected cells mediates potent plasmacytoid dendritic cell activation
Early and strong interferon type I (IFN-I) responses are usually associated with mild COVID-19 disease, whereas persistent...
Mass cytometry uncovers a distinct peripheral immune profile and upregulated CD38 expression in patients with hidradenitis suppurativa
Mass cytometry uncovers a distinct peripheral immune profile and upregulated CD38 expression in patients with hidradenitis suppurativa
Competing interests IH has served as an investigator (grant to institution) for ...
Discovery of highly immunogenic spleen-resident FCGR3+CD103+ cDC1s differentiated by IL-33-primed ST2+ basophils
Discovery of highly immunogenic spleen-resident FCGR3+CD103+ cDC1s differentiated by IL-33-primed ST2+ basophils
Recombinant interleukin-33 (IL-33) inhibits tumor growth, but the detailed immunological mechanism is still unknown. IL-33...
Author Correction: Tumor-specific memory CD8+ T cells are strictly resident in draining lymph nodes during tumorigenesis
In this article, the affiliation details were incorrectly given as ‘1Institute of Immunology, Third Military Medical Unive...
Reciprocal costimulatory molecules control the activation of mucosal type 3 innate lymphoid cells during engagement with B cells
Reciprocal costimulatory molecules control the activation of mucosal type 3 innate lymphoid cells during engagement with B cells
Innate lymphoid cells (ILCs) are the counterpart of T helper cells in the innate immune system and share multiple phenotyp...
Author Correction: A crucial role of the PD-1H coinhibitory receptor in suppressing experimental asthma
Authors and AffiliationsLaboratory of Immunotherapy, Sun Yet-Sen University, Guangzhou, Guangdong, People’s Republic of Ch...
Vitamin B6 regulates IL-33 homeostasis to alleviate type 2 inflammation
Vitamin B6 regulates IL-33 homeostasis to alleviate type 2 inflammation
Interleukin-33 (IL-33) is a crucial nuclear cytokine that induces the type 2 immune response and maintains immune homeosta...
Intricacies of TGF-β signaling in Treg and Th17 cell biology
Intricacies of TGF-β signaling in Treg and Th17 cell biology
Balanced immunity is pivotal for health and homeostasis. CD4+ helper T (Th) cells are central to the balance between immun...
Mesenchymal stem/stromal cells (MSCs): origin, immune regulation, and clinical applications
Mesenchymal stem/stromal cells (MSCs): origin, immune regulation, and clinical applications
Dr. Yufang Shi Dr. Jun ZhouThe associations between inflam...
The chemokine monocyte chemoattractant protein-1/CCL2 is a promoter of breast cancer metastasis
The chemokine monocyte chemoattractant protein-1/CCL2 is a promoter of breast cancer metastasis
Breast cancer is the most prevalent cancer worldwide, and metastasis is the leading cause of death in cancer patients. Hum...
Hyaluronan as an immunological adjuvant: a novel application for an ancient molecule
Hyaluronan as an immunological adjuvant: a novel application for an ancient molecule
Vaccines are among the most important scientific breakthroughs in human history. However, both the recent...
New genetic and epigenetic insights into the chemokine system: the latest discoveries aiding progression toward precision medicine
New genetic and epigenetic insights into the chemokine system: the latest discoveries aiding progression toward precision medicine
Over the past thirty years, the importance of chemokines and their seven-transmembrane G protein-coupled receptors (GPCRs)...
Invariant natural killer T cells and iron metabolism orchestrate skin development and homeostasis
Invariant natural killer T cells and iron metabolism orchestrate skin development and homeostasis
We thank Edanz (https://jp.edanz.com/ac) for editing a draft of this manuscript. Funding This ...
Host cell entry and neutralisation sensitivity of the SARS-CoV-2 XBB.1.16 lineage
Host cell entry and neutralisation sensitivity of the SARS-CoV-2 XBB.1.16 lineage
We gratefully acknowledge the originating laboratories responsible for obtaining the specimens, as well as the submitting ...
Tempering of exhausted T cells to comprehend their adaptive response for suitable clinical translation
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
CTLA4 protects against maladaptive cytotoxicity during the differentiation of effector and follicular CD4+ T cells
CTLA4 protects against maladaptive cytotoxicity during the differentiation of effector and follicular CD4+ T cells
As chronic antigenic stimulation from infection and autoimmunity is a feature of primary antibody deficiency (PAD), analys...
The immune hunger games: the effects of fasting on monocytes
The immune hunger games: the effects of fasting on monocytes
Currently, different types of fasting are becoming increasingly popular for their potential health benefi...
Current perspectives on mesenchymal stromal cell therapy for graft versus host disease
Current perspectives on mesenchymal stromal cell therapy for graft versus host disease
Graft versus host disease (GvHD) is the clinical condition in which bone marrow-derived mesenchymal stromal cells (MSCs) h...
Revisiting the role of mesenchymal stem cells in tuberculosis and other infectious diseases
Revisiting the role of mesenchymal stem cells in tuberculosis and other infectious diseases
Mesenchymal stem cells (MSCs) play diverse roles ranging from regeneration and wound healing to immune signaling. Recent i...
Author Correction: Mesenchymal stromal cells in hepatic fibrosis/cirrhosis: from pathogenesis to treatment
Author Correction: Mesenchymal stromal cells in hepatic fibrosis/cirrhosis: from pathogenesis to treatment
These authors contributed equally: Xue Yang, Qing Li, Wenting Liu.Department of Tumor Immunology and Gene Therapy Center, ...
Author Correction: SARS-CoV-2 ORF10 suppresses the antiviral innate immune response by degrading MAVS through mitophagy
Author Correction: SARS-CoV-2 ORF10 suppresses the antiviral innate immune response by degrading MAVS through mitophagy
These authors contributed equally: Xingyu Li, Peili Hou, Wenqing Ma, Xuefeng Wang.Ruminant Diseases Research Center, Colle...
Emerging roles of bile acids in chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma
Emerging roles of bile acids in chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma
Chronic hepatitis leads to cirrhosis and liver cancer, which are the final stages of the liver disease process. Hepatitis ...
Culture-expanded mesenchymal stromal cell therapy: does it work in knee osteoarthritis? A pathway to clinical success
Culture-expanded mesenchymal stromal cell therapy: does it work in knee osteoarthritis? A pathway to clinical success
Osteoarthritis (OA) is a degenerative multifactorial disease with concomitant structural, inflammatory, and metabolic chan...
The critical role of apoptosis in mesenchymal stromal cell therapeutics and implications in homeostasis and normal tissue repair
The critical role of apoptosis in mesenchymal stromal cell therapeutics and implications in homeostasis and normal tissue repair
Mesenchymal stromal cells (MSCs) have been extensively tested for the treatment of numerous clinical conditions and have d...
Revealing the identity of regulatory T-cell-suppressed self-reactive CD4+ T cells
Revealing the identity of regulatory T-cell-suppressed self-reactive CD4+ T cells
Lee V, Rodriguez DM, Ganci NK, Zeng S, Ai J, Chao JL, et al. The endogenous repertoire harbors self-reactive CD4+ T cell c...
A novel role for mitochondrial fission in macrophages: trained innate immunity induced by beta-glucan
A novel role for mitochondrial fission in macrophages: trained innate immunity induced by beta-glucan
In a recent paper published in Nature Immunology, Ding et al. provided new insights into the mechanism of...
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