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How location and cellular signaling combine to activate the NLRP3 inflammasome
How location and cellular signaling combine to activate the NLRP3 inflammasome
NOD-, LRR-, and pyrin domain-containing 3 (NLRP3) is a cytosolic innate immune sensor of cellular stress signals, triggere...
Sphingosine kinase 1 promotes tumor immune evasion by regulating the MTA3-PD-L1 axis
Sphingosine kinase 1 promotes tumor immune evasion by regulating the MTA3-PD-L1 axis
Immune checkpoint blockade (ICB) exhibits considerable benefits in malignancies, but its overall response rate is limited....
Emerging roles of ILC2s in antitumor immunity
Emerging roles of ILC2s in antitumor immunity
Vivier E, Artis D, Colonna M, Diefenbach A, Di Santo JP, Eberl G, et al. Innate lymphoid cells: 10 years on.Cells. 2018;17...
Redox regulation of the immune response
Redox regulation of the immune response
The immune-inflammatory response is associated with increased nitro-oxidative stress. The aim of this mechanistic review i...
Cbf-β is required for the development, differentiation, and function of murine mucosal-associated invariant T cells
Cbf-β is required for the development, differentiation, and function of murine mucosal-associated invariant T cells
We would like to thank the NIH tetramer core for providing tetramers, Peter Dimitrion, Nirmal Parajuli for performing tamo...
S1P/S1PR1 signaling differentially regulates the allogeneic response of CD4 and CD8 T cells by modulating mitochondrial fission
S1P/S1PR1 signaling differentially regulates the allogeneic response of CD4 and CD8 T cells by modulating mitochondrial fission
Graft-versus-host disease (GVHD) significantly contributes to patient morbidity and mortality after allogeneic hematopoiet...
Immunopathogenesis of idiopathic nephrotic syndrome
Immunopathogenesis of idiopathic nephrotic syndrome
Lane BM, Cason R, Esezobor CI, Gbadegesin RA. Genetics of childhood steroid sensitive nephrotic syndrome: an update. Front...
Myc inhibition tips the immune balance to promote antitumor immunity
Myc inhibition tips the immune balance to promote antitumor immunity
Aberrant expression of Myc is one of the most common oncogenic events in human cancers. Scores of Myc inhibitors are curre...
Role of pyroptosis in inflammation and cancer
Role of pyroptosis in inflammation and cancer
Pyroptosis is a form of programmed cell death mediated by gasdermin and is a product of continuous cell expansion until th...
Virus-like particle vaccinology, from bench to bedside
Virus-like particle vaccinology, from bench to bedside
Virus-like particles (VLPs) have become key tools in biology, medicine and even engineering. After their initial use to re...
Tumor-associated macrophage (TAM)-derived CCL22 induces FAK addiction in esophageal squamous cell carcinoma (ESCC)
Tumor-associated macrophage (TAM)-derived CCL22 induces FAK addiction in esophageal squamous cell carcinoma (ESCC)
Tumor cell dependence on activated oncogenes is considered a therapeutic target, but protumorigenic microenvironment-media...
The unique role of innate lymphoid cells in cancer and the hepatic microenvironment
The unique role of innate lymphoid cells in cancer and the hepatic microenvironment
Cancer is a complex disease, and despite incredible progress over the last decade, it remains the leading cause of death w...
Revisiting the role of human memory CD8+ T cells in immune surveillance
Revisiting the role of human memory CD8+ T cells in immune surveillance
Haluszczak C, et al. The antigen-specific CD8+ T cell repertoire in unimmunized mice includes memory phenotype cells beari...
Aging induces severe SIV infection accompanied by an increase in follicular CD8+ T cells with overactive STAT3 signaling
Aging induces severe SIV infection accompanied by an increase in follicular CD8+ T cells with overactive STAT3 signaling
The number of elderly people living with HIV is increasing globally, and the condition of this population is relatively co...
Author Correction to: SARS-CoV-2 interaction with Siglec-1 mediates trans-infection by dendritic cells
Author Correction to: SARS-CoV-2 interaction with Siglec-1 mediates trans-infection by dendritic cells
Marc Noguera-JulianPresent address: University of Vic—Central University of Catalonia (UVic-UCC), Vic, 08500, SpainThese a...
Glucose metabolism controls human γδ T-cell-mediated tumor immunosurveillance in diabetes
Glucose metabolism controls human γδ T-cell-mediated tumor immunosurveillance in diabetes
Patients with type 2 diabetes mellitus (T2DM) have an increased risk of cancer. The effect of glucose metabolism on γ...
Vascular macrophages sense octanal and drive athero-inflammation
Vascular macrophages sense octanal and drive athero-inflammation
This work was supported by grants from the National Natural Science Foundation of China (Nos. 81970373, 31770977 and 81920...
Neutralizing antibodies and their cocktails against SARS-CoV-2 Omicron and other circulating variants
Neutralizing antibodies and their cocktails against SARS-CoV-2 Omicron and other circulating variants
Jiang S, Zhang X, Du L. Therapeutic antibodies and fusion inhibitors targeting the spike protein of SARS-CoV-2. Expert Opi...
ACPA-CD147 axis in the NLRP3 inflammasome of RA macrophages
ACPA-CD147 axis in the NLRP3 inflammasome of RA macrophages
Dong X, Zheng Z, Lin P, Fu X, Li F, Jiang J, et al. ACPAs promote IL-1beta production in rheumatoid arthritis by activatin...