SCI时时刷

search
+
Alternative mRNA polyadenylation regulates macrophage hyperactivation via the autophagy pathway
Alternative mRNA polyadenylation regulates macrophage hyperactivation via the autophagy pathway
Macrophage hyperactivation is a hallmark of inflammatory diseases, yet the role of alternative polyadenylation (APA) of mR...
Metabolic rewiring controlled by HIF-1α tunes IgA-producing B-cell differentiation and intestinal inflammation
Metabolic rewiring controlled by HIF-1α tunes IgA-producing B-cell differentiation and intestinal inflammation
Germinal centers where B cells undergo clonal expansion and antibody affinity maturation are hypoxic microenvironments. Ho...
Critical and differential roles of eIF4A1 and eIF4A2 in B-cell development and function
Critical and differential roles of eIF4A1 and eIF4A2 in B-cell development and function
Eukaryotic initiation factor 4 A (eIF4A) plays critical roles during translation initiation of cellular mRNAs by for...
Targeting of TAMs: can we be more clever than cancer cells?
Targeting of TAMs: can we be more clever than cancer cells?
With increasing incidence and geography, cancer is one of the leading causes of death, reduced quality of life and disabil...
Targeting GSDME-mediated macrophage polarization for enhanced antitumor immunity in hepatocellular carcinoma
Targeting GSDME-mediated macrophage polarization for enhanced antitumor immunity in hepatocellular carcinoma
Despite the notable efficacy of anti-PD1 therapy in the management of hepatocellular carcinoma (HCC) patients, resistance ...
Glut3 promotes cellular O-GlcNAcylation as a distinctive tumor-supportive feature in Treg cells
Glut3 promotes cellular O-GlcNAcylation as a distinctive tumor-supportive feature in Treg cells
Regulatory T cells (Tregs) establish dominant immune tolerance but obstruct tumor immune surveillance, warranting context-...
Specific ECM degradation potentiates the antitumor activity of CAR-T cells in solid tumors
Specific ECM degradation potentiates the antitumor activity of CAR-T cells in solid tumors
Although major progress has been made in the use of chimeric antigen receptor (CAR)-T-cell therapy for hematological malig...
Ubiquitin regulatory X (UBX) domain-containing protein 6 is essential for autophagy induction and inflammation control in macrophages
Ubiquitin regulatory X (UBX) domain-containing protein 6 is essential for autophagy induction and inflammation control in macrophages
Ubiquitin regulatory X (UBX) domain-containing protein 6 (UBXN6) is an essential cofactor for the activity of the valosin-...
Age-associated imbalance in immune cell regeneration varies across individuals and arises from a distinct subset of stem cells
Age-associated imbalance in immune cell regeneration varies across individuals and arises from a distinct subset of stem cells
The age-associated decline in immunity manifests as imbalanced adaptive and innate immune cells, which originate from the ...
Kynurenine-AhR reduces T-cell infiltration and induces a delayed T-cell immune response by suppressing the STAT1-CXCL9/CXCL10 axis in tuberculosis
Kynurenine-AhR reduces T-cell infiltration and induces a delayed T-cell immune response by suppressing the STAT1-CXCL9/CXCL10 axis in tuberculosis
Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), is a critical global health issue that is complicated by the abi...
No more LAGging behind PD-1: uncovering the unique role of LAG-3 in T-cell exhaustion
No more LAGging behind PD-1: uncovering the unique role of LAG-3 in T-cell exhaustion
Zander R, Cui W. Exhausted CD8(+) T cells face a developmental fork in the road. Trends Immunol. 2023;44:276–86.Article  ...
CD30 influences germinal center B-cell dynamics and the expansion of IgG1-switched B cells
CD30 influences germinal center B-cell dynamics and the expansion of IgG1-switched B cells
Initially, identified as a Hodgkin lymphoma marker, CD30 was subsequently detected on a subset of human B cells within and...
Regulation of CD8+ T cells by lipid metabolism in cancer progression
Regulation of CD8+ T cells by lipid metabolism in cancer progression
Dysregulation of lipid metabolism is a key characteristic of the tumor microenvironment, where tumor cells utilize lipids ...
Macrophage diversity in cancer dissemination and metastasis
Macrophage diversity in cancer dissemination and metastasis
Invasion and metastasis are hallmarks of cancer. In addition to the well-recognized hematogenous and lymphatic pathways of...
Immunotherapy for glioblastoma: current state, challenges, and future perspectives
Immunotherapy for glioblastoma: current state, challenges, and future perspectives
Glioblastoma (GBM) is an aggressive and lethal type of brain tumor in human adults. The standard of care offers minimal cl...
Author Correction: Fatty acid metabolism constrains Th9 cell differentiation and antitumor immunity via the modulation of retinoic acid receptor signaling
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Type 17 immunity: novel insights into intestinal homeostasis and autoimmune pathogenesis driven by gut-primed T cells 
Type 17 immunity: novel insights into intestinal homeostasis and autoimmune pathogenesis driven by gut-primed T cells 
The IL-23 signaling pathway in both innate and adaptive immune cells is vital for orchestrating type 17 immunity, which is...
Silencing of SIRPα enhances the antitumor efficacy of CAR-M in solid tumors
Silencing of SIRPα enhances the antitumor efficacy of CAR-M in solid tumors
The potential of macrophage-mediated phagocytosis as a cancer treatment is promising. Blocking the CD47–SIRPα i...
The TET3 inflammasome senses unique long HSV-1 proteins for virus particle budding from the nucleus
The TET3 inflammasome senses unique long HSV-1 proteins for virus particle budding from the nucleus
Inflammasomes play important roles in resisting infections caused by various pathogens. HSV-1 is a highly contagious virus...
MLKL-mediated endothelial necroptosis drives vascular damage and mortality in systemic inflammatory response syndrome
MLKL-mediated endothelial necroptosis drives vascular damage and mortality in systemic inflammatory response syndrome
The hypersecretion of cytokines triggers life-threatening systemic inflammatory response syndrome (SIRS), leading to multi...
Hepatocellular carcinoma-specific epigenetic checkpoints bidirectionally regulate the antitumor immunity of CD4 + T cells
Hepatocellular carcinoma-specific epigenetic checkpoints bidirectionally regulate the antitumor immunity of CD4 + T cells
Hepatocellular carcinoma (HCC) is a highly malignant tumor with significant global health implications. The role of CD4+ T...
Author Correction: Priming with FLO8-deficient Candida albicans induces Th1-biased protective immunity against lethal polymicrobial sepsis
Author Correction: Priming with FLO8-deficient Candida albicans induces Th1-biased protective immunity against lethal polymicrobial sepsis
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Rack1 regulates B-cell development and function by binding to and stabilizing the transcription factor Pax5
Rack1 regulates B-cell development and function by binding to and stabilizing the transcription factor Pax5
The transcription factor Pax5 activates genes essential for B-cell development and function. However, the regulation of Pa...
RBM25 is required to restrain inflammation via ACLY RNA splicing-dependent metabolism rewiring
RBM25 is required to restrain inflammation via ACLY RNA splicing-dependent metabolism rewiring
Spliceosome dysfunction and aberrant RNA splicing underline unresolved inflammation and immunopathogenesis. Here, we revea...
The emerging roles of B cells in cancer development
The emerging roles of B cells in cancer development
Liwei Lu dedicates this work to his mentor Dr Dennis G. Osmond at McGill University for his pioneering work in B cell immu...
Fatty acid metabolism constrains Th9 cell differentiation and antitumor immunity via the modulation of retinoic acid receptor signaling
Fatty acid metabolism constrains Th9 cell differentiation and antitumor immunity via the modulation of retinoic acid receptor signaling
T helper 9 (Th9) cells are interleukin 9 (IL-9)-producing cells that have diverse functions ranging from antitumor immune ...
SIRPα engagement regulates ILC2 effector function and alleviates airway hyperreactivity via modulating energy metabolism
SIRPα engagement regulates ILC2 effector function and alleviates airway hyperreactivity via modulating energy metabolism
Group-2 innate lymphoid cells (ILC2) are part of a growing family of innate lymphocytes known for their crucial role in bo...
Engineered mitochondria exert potent antitumor immunity as a cancer vaccine platform
Engineered mitochondria exert potent antitumor immunity as a cancer vaccine platform
The preferable antigen delivery profile accompanied by sufficient adjuvants favors vaccine efficiency. Mitochondria, which...
IL-33 released during challenge phase regulates allergic asthma in an age-dependent way
IL-33 released during challenge phase regulates allergic asthma in an age-dependent way
Epithelial-derived cytokines, especially type 2 alarmins (TSLP, IL-25, and IL-33), have emerged as critical mediators of t...
The influence of metabolic disorders on adaptive immunity
The influence of metabolic disorders on adaptive immunity
The immune system plays a crucial role in protecting the body from invading pathogens and maintaining tissue homoeostasis....
阅读更多
format_indent_increase