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Inhibition of METTL3 in macrophages provides protection against intestinal inflammation
Inhibition of METTL3 in macrophages provides protection against intestinal inflammation
Inflammatory bowel disease (IBD) is prevalent, and no satisfactory therapeutic options are available because the mechanism...
Lkb1 orchestrates γδ T-cell metabolic and functional fitness to control IL-17-mediated autoimmune hepatitis
Lkb1 orchestrates γδ T-cell metabolic and functional fitness to control IL-17-mediated autoimmune hepatitis
γδ T cells play a crucial role in immune surveillance and serve as a bridge between innate and adaptive immunity...
Targeting macrophage metabolism to enhance tumor immunotherapy
Targeting macrophage metabolism to enhance tumor immunotherapy
This study was funded by the National Natural Science Foundation of China (NSFC) (82071771, 82271807 to PL), the Hubei Pro...
Bypassing PELO-mediated ATPase activation of the NLR is a common pathogenic cause of NLR-associated autoinflammatory diseases
Bypassing PELO-mediated ATPase activation of the NLR is a common pathogenic cause of NLR-associated autoinflammatory diseases
We thank Lu Zhou for help with proofreading the manuscript. This work was supported by the National Natural Science Founda...
Neuropilin-1high monocytes protect against neonatal inflammation
Neuropilin-1high monocytes protect against neonatal inflammation
Neonates are susceptible to inflammatory disorders such as necrotizing enterocolitis (NEC) due to their immature immune sy...
Synthetic biology approaches for improving the specificity and efficacy of cancer immunotherapy
Synthetic biology approaches for improving the specificity and efficacy of cancer immunotherapy
Immunotherapy has shown robust efficacy in treating a broad spectrum of hematological and solid cancers. Despite the trans...
Cellular metabolism regulates the differentiation and function of T-cell subsets
Cellular metabolism regulates the differentiation and function of T-cell subsets
T cells are an important component of adaptive immunity and protect the host from infectious diseases and cancers. However...
GSNOR negatively regulates the NLRP3 inflammasome via S-nitrosation of MAPK14
GSNOR negatively regulates the NLRP3 inflammasome via S-nitrosation of MAPK14
Hyperactivation of the NLRP3 inflammasome has been implicated in the pathogenesis of numerous diseases. However, the preci...
Novel insights into regulation of butyrophilin molecules: critical components of cancer immunosurveillance by γδ T cells
Novel insights into regulation of butyrophilin molecules: critical components of cancer immunosurveillance by γδ T cells
Members of the butyrophilin (BTN) family of transmembrane molecules play an important role in the act...
The chemerin-CMKLR1 axis in keratinocytes impairs innate host defense against cutaneous Staphylococcus aureus infection
The chemerin-CMKLR1 axis in keratinocytes impairs innate host defense against cutaneous Staphylococcus aureus infection
The skin is the most common site of Staphylococcus aureus infection, which can lead to various diseases, including invasiv...
Defining two subpopulations of marginal zone B cells
Defining two subpopulations of marginal zone B cells
Pillai S, Cariappa A. The follicular versus marginal zone B lymphocyte cell fate decision. Nat Rev Immunol. 2009;9:767–77....
Aerobic glycolysis enables the effector differentiation potential of stem-like CD4+ T cells to combat cancer
Aerobic glycolysis enables the effector differentiation potential of stem-like CD4+ T cells to combat cancer
In 1957, Macfarlane Burnet proposed the theory that harnessing the body’s immune system could be an effective method for c...
Insm1: orchestrating cellular mimicry in the thymus medulla
Insm1: orchestrating cellular mimicry in the thymus medulla
James KD, Cosway EJ, Parnell SM, White AJ, Jenkinson WE, Anderson G. Assembling the thymus medulla: Development and functi...
Neutrophil ALDH2 is a new therapeutic target for the effective treatment of sepsis-induced ARDS
Neutrophil ALDH2 is a new therapeutic target for the effective treatment of sepsis-induced ARDS
Acetaldehyde dehydrogenase 2 (ALDH2) mutations are commonly found in a subgroup of the Asian population. However, the role...
gp120-derived amyloidogenic peptides form amyloid fibrils that increase HIV-1 infectivity
gp120-derived amyloidogenic peptides form amyloid fibrils that increase HIV-1 infectivity
Apart from mediating viral entry, the function of the free HIV-1 envelope protein (gp120) has yet to be elucidated. Our gr...
Development of NK cell-based cancer immunotherapies through receptor engineering
Development of NK cell-based cancer immunotherapies through receptor engineering
Natural killer (NK) cell-based immunotherapies are attracting increasing interest in the field of cancer treatment. Early ...
Engagement of sialylated glycans with Siglec receptors on suppressive myeloid cells inhibits anticancer immunity via CCL2
Engagement of sialylated glycans with Siglec receptors on suppressive myeloid cells inhibits anticancer immunity via CCL2
The overexpression of sialic acids on glycans, called hypersialylation, is a common alteration found in cancer cells. Sial...
Neutrophils in the tumor microenvironment – when a company becomes a crowd
Neutrophils in the tumor microenvironment – when a company becomes a crowd
Traditionally, neutrophils are perceived as terminally differentiated cells with defined functions an...
Mucosal T-cell responses to chronic viral infections: Implications for vaccine design
Mucosal T-cell responses to chronic viral infections: Implications for vaccine design
Mucosal surfaces that line the respiratory, gastrointestinal and genitourinary tracts are the major interfaces between the...
Author Correction: Tissue-resident macrophages exacerbate lung injury after remote sterile damage
Author Correction: Tissue-resident macrophages exacerbate lung injury after remote sterile damage
Author notesThese authors contributed equally: Hanhui Zhong, Jingjing Ji, Jinling Zhuang.Authors and AffiliationsThe Depar...
Two distinct subpopulations of marginal zone B cells exhibit differential antibody-producing capacities and radioresistance
Two distinct subpopulations of marginal zone B cells exhibit differential antibody-producing capacities and radioresistance
Marginal zone (MZ) B cells, which are splenic innate-like B cells that rapidly secrete antibodies (Abs) against b...
Targeting PHGDH reverses the immunosuppressive phenotype of tumor-associated macrophages through α-ketoglutarate and mTORC1 signaling
Targeting PHGDH reverses the immunosuppressive phenotype of tumor-associated macrophages through α-ketoglutarate and mTORC1 signaling
Phosphoglycerate dehydrogenase (PHGDH) has emerged as a crucial factor in macromolecule synthesis, neutralizing oxidative ...
Inactivation of TGF-β signaling in CAR-T cells
Inactivation of TGF-β signaling in CAR-T cells
Chong EA, Melenhorst JJ, Lacey SF, Ambrose DE, Gonzalez V, Levine BL, et al. PD-1 blockade modulates chimeric antigen rece...
Coming of age: the formation and function of age-associated B cells
Coming of age: the formation and function of age-associated B cells
This work was supported by the National Natural Science Foundation of China (82071817, 82171793, 82371803), the Shenzhen S...
NLRP3 inflammasome activation and NETosis positively regulate each other and exacerbate proinflammatory responses: implications of NETosis inhibition for acne skin inflammation treatment
NLRP3 inflammasome activation and NETosis positively regulate each other and exacerbate proinflammatory responses: implications of NETosis inhibition for acne skin inflammation treatment
Inflammasomes are multiprotein complexes involved in the host immune response to pathogen infections. Thus, inflammasomes ...
Unsynchronized butyrophilin molecules dictate cancer cell evasion of Vγ9Vδ2 T-cell killing
Unsynchronized butyrophilin molecules dictate cancer cell evasion of Vγ9Vδ2 T-cell killing
Vγ9Vδ2 T cells are specialized effector cells that have gained prominence as immunotherapy agents due to their a...
CD4+ T cells produce IFN-I to license cDC1s for induction of cytotoxic T-cell activity in human tumors
CD4+ T cells produce IFN-I to license cDC1s for induction of cytotoxic T-cell activity in human tumors
CD4+ T cells can "help” or "license” conventional type 1 dendritic cells (cDC1s) to induce CD8+ cyto...
CD200Rhigh neutrophils with dysfunctional autophagy establish systemic immunosuppression by increasing regulatory T cells
CD200Rhigh neutrophils with dysfunctional autophagy establish systemic immunosuppression by increasing regulatory T cells
Distinct neutrophil populations arise during certain pathological conditions. The generation of dysfunctional neutrophils ...
Activation of leukotriene B4 receptor 1 is a prerequisite for complement receptor 3-mediated antifungal responses of neutrophils
Activation of leukotriene B4 receptor 1 is a prerequisite for complement receptor 3-mediated antifungal responses of neutrophils
Invasive fungal infections are life-threatening, and neutrophils are vital cells of the innate immune system that defend a...
Id2 epigenetically controls CD8+ T-cell exhaustion by disrupting the assembly of the Tcf3-LSD1 complex
Id2 epigenetically controls CD8+ T-cell exhaustion by disrupting the assembly of the Tcf3-LSD1 complex
CD8+ T-cell exhaustion is a state of dysfunction that promotes tumor progression and is marked by the generation of Slamf6...
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