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Author Correction: Tissue-resident macrophages exacerbate lung injury after remote sterile damage
Author Correction: Tissue-resident macrophages exacerbate lung injury after remote sterile damage
Author notesThese authors contributed equally: Hanhui Zhong, Jingjing Ji, Jinling Zhuang.Authors and AffiliationsThe Depar...
Two distinct subpopulations of marginal zone B cells exhibit differential antibody-producing capacities and radioresistance
Two distinct subpopulations of marginal zone B cells exhibit differential antibody-producing capacities and radioresistance
Marginal zone (MZ) B cells, which are splenic innate-like B cells that rapidly secrete antibodies (Abs) against b...
Inactivation of TGF-β signaling in CAR-T cells
Inactivation of TGF-β signaling in CAR-T cells
Chong EA, Melenhorst JJ, Lacey SF, Ambrose DE, Gonzalez V, Levine BL, et al. PD-1 blockade modulates chimeric antigen rece...
Coming of age: the formation and function of age-associated B cells
Coming of age: the formation and function of age-associated B cells
This work was supported by the National Natural Science Foundation of China (82071817, 82171793, 82371803), the Shenzhen S...
Unsynchronized butyrophilin molecules dictate cancer cell evasion of Vγ9Vδ2 T-cell killing
Unsynchronized butyrophilin molecules dictate cancer cell evasion of Vγ9Vδ2 T-cell killing
Vγ9Vδ2 T cells are specialized effector cells that have gained prominence as immunotherapy agents due to their a...
CD4+ T cells produce IFN-I to license cDC1s for induction of cytotoxic T-cell activity in human tumors
CD4+ T cells produce IFN-I to license cDC1s for induction of cytotoxic T-cell activity in human tumors
CD4+ T cells can "help” or "license” conventional type 1 dendritic cells (cDC1s) to induce CD8+ cyto...
CD200Rhigh neutrophils with dysfunctional autophagy establish systemic immunosuppression by increasing regulatory T cells
CD200Rhigh neutrophils with dysfunctional autophagy establish systemic immunosuppression by increasing regulatory T cells
Distinct neutrophil populations arise during certain pathological conditions. The generation of dysfunctional neutrophils ...
Activation of leukotriene B4 receptor 1 is a prerequisite for complement receptor 3-mediated antifungal responses of neutrophils
Activation of leukotriene B4 receptor 1 is a prerequisite for complement receptor 3-mediated antifungal responses of neutrophils
Invasive fungal infections are life-threatening, and neutrophils are vital cells of the innate immune system that defend a...
Id2 epigenetically controls CD8+ T-cell exhaustion by disrupting the assembly of the Tcf3-LSD1 complex
Id2 epigenetically controls CD8+ T-cell exhaustion by disrupting the assembly of the Tcf3-LSD1 complex
CD8+ T-cell exhaustion is a state of dysfunction that promotes tumor progression and is marked by the generation of Slamf6...
COVID-19 vaccines and beyond
COVID-19 vaccines and beyond
Khoury DS, Cromer D, Reynaldi A, Schlub TE, Wheatley AK, Juno JA, et al. Neutralizing antibody levels are highly predictiv...
Disulfiram ameliorates STING/MITA-dependent inflammation and autoimmunity by targeting RNF115
Disulfiram ameliorates STING/MITA-dependent inflammation and autoimmunity by targeting RNF115
STING (also known as MITA) is an adaptor protein that mediates cytoplasmic DNA-triggered signaling, and aberrant activatio...
SARS-CoV-2 immunity
SARS-CoV-2 immunity
Dr. Antonio BertolettiFour years have swiftly passed since the identification of a novel coronavirus ...
SARS-CoV-2 immunity in animal models
SARS-CoV-2 immunity in animal models
The COVID-19 pandemic, which was caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a worl...
CD8+ T cell metabolic flexibility elicited by CD28-ARS2 axis-driven alternative splicing of PKM supports antitumor immunity
CD8+ T cell metabolic flexibility elicited by CD28-ARS2 axis-driven alternative splicing of PKM supports antitumor immunity
Metabolic flexibility has emerged as a critical determinant of CD8+ T-cell antitumor activity, yet the mechanisms driving ...
Tissue-resident macrophages exacerbate lung injury after remote sterile damage
Tissue-resident macrophages exacerbate lung injury after remote sterile damage
Remote organ injury, which is a common secondary complication of sterile tissue damage, is a major cause of poor prognosis...
Not to be and how not to be: the questions of Tregs controlled by RIPK1
Not to be and how not to be: the questions of Tregs controlled by RIPK1
The authors apologize to colleagues whose work inspired this review but could not be cited owing to space limitations. Thi...
Silent battles: immune responses in asymptomatic SARS-CoV-2 infection
Silent battles: immune responses in asymptomatic SARS-CoV-2 infection
SARS-CoV-2 infections manifest with a broad spectrum of presentations, ranging from asymptomatic infections to severe pneu...
Nuclear receptor coactivator 6 is a critical regulator of NLRP3 inflammasome activation and gouty arthritis
Nuclear receptor coactivator 6 is a critical regulator of NLRP3 inflammasome activation and gouty arthritis
Transcriptional coactivators regulate the rate of gene expression in the nucleus. Nuclear receptor coactivator 6 (NCOA6), ...
SMAD7 expression in CAR-T cells improves persistence and safety for solid tumors
SMAD7 expression in CAR-T cells improves persistence and safety for solid tumors
Despite the tremendous progress of chimeric antigen receptor T (CAR-T) cell therapy in hematological malignancies, their a...
In search of a pan-coronavirus vaccine: next-generation vaccine design and immune mechanisms
In search of a pan-coronavirus vaccine: next-generation vaccine design and immune mechanisms
Members of the coronaviridae family are endemic to human populations and have caused several epidemics and pandemics in re...
Olfactory immune response to SARS-CoV-2
Olfactory immune response to SARS-CoV-2
Numerous pathogens can infect the olfactory tract, yet the pandemic caused by SARS-CoV-2 has strongly emphasized the impor...
The RNA m6A demethylase ALKBH5 drives emergency granulopoiesis and neutrophil mobilization by upregulating G-CSFR expression
The RNA m6A demethylase ALKBH5 drives emergency granulopoiesis and neutrophil mobilization by upregulating G-CSFR expression
Emergency granulopoiesis and neutrophil mobilization that can be triggered by granulocyte colony-stimulating factor (G-CSF...
Thirteen years to get from b to a: one of the neglected isoforms of IL-37 enters the stage
Rudloff I, Cho SX, Lao JC, Ngo D, McKenzie M, Nold-Petry CA, et al. Monocytes and dendritic cells are the primary sources ...
Metabolic reprogramming by Syntenin-1 directs RA FLS and endothelial cell-mediated inflammation and angiogenesis
Metabolic reprogramming by Syntenin-1 directs RA FLS and endothelial cell-mediated inflammation and angiogenesis
A novel rheumatoid arthritis (RA) synovial fluid protein, Syntenin-1, and its receptor, Syndecan-1 (SDC-1), are colocalize...
The E3 ubiquitin ligase TRAF6 controls CTLA-4 turnover and promotes T-cell-mediated antitumor immunity
The E3 ubiquitin ligase TRAF6 controls CTLA-4 turnover and promotes T-cell-mediated antitumor immunity
Work in the Zhou Lab is funded by the Key Project of the National Natural Science Foundation of China (81830093), the Non-...
RIPK1 plays a crucial role in maintaining regulatory T-Cell homeostasis by inhibiting both RIPK3- and FADD-mediated cell death
RIPK1 plays a crucial role in maintaining regulatory T-Cell homeostasis by inhibiting both RIPK3- and FADD-mediated cell death
Regulatory T (Treg) cells play an essential role in maintaining immune balance across various physiological and pathologic...