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Food restriction heals darkness-related second brain inflammation
Food restriction heals darkness-related second brain inflammation
Koronowski KB, Kinouchi K, Welz PS, Smith JG, Zinna VM, Shi J, et al. Defining the Independence of the Liver Circadian Clo...
Extramedullary neutrophil progenitors: Quo Vadis?
Extramedullary neutrophil progenitors: Quo Vadis?
Billard MJ, Gruver AL, Sempowski GD. Acute endotoxin-induced thymic atrophy is characterized by intrathymic inflammatory a...
Targeting pro-fibrotic macrophages with bioactive self-assembly peptides to retard kidney fibrosis – know thyself
Targeting pro-fibrotic macrophages with bioactive self-assembly peptides to retard kidney fibrosis – know thyself
Ouyang Q, Wang C, Sang T, Tong Y, Zhang J, Chen Y, et al. Depleting profibrotic macrophages using bioactivated in vivo ass...
Orchestration of antiviral responses within the infected central nervous system
Orchestration of antiviral responses within the infected central nervous system
Many newly emerging and re-emerging viruses have neuroinvasive potential, underscoring viral encephalitis as a global rese...
GPR34 senses demyelination to promote neuroinflammation and pathologies
GPR34 senses demyelination to promote neuroinflammation and pathologies
Sterile neuroinflammation is a major driver of multiple neurological diseases. Myelin debris can act as an inflammatory st...
Tissue-resident memory T cells break tolerance to renal autoantigens and orchestrate immune-mediated nephritis
Tissue-resident memory T cells break tolerance to renal autoantigens and orchestrate immune-mediated nephritis
Immune-mediated nephritis is a leading cause of acute kidney injury and chronic kidney disease. While the role of B cells ...
4-1BB-encoding CAR causes cell death via sequestration of the ubiquitin-modifying enzyme A20
4-1BB-encoding CAR causes cell death via sequestration of the ubiquitin-modifying enzyme A20
CD28 and 4-1BB costimulatory endodomains included in chimeric antigen receptor (CAR) molecules play a critical role in pro...
Lipid droplet accumulation mediates macrophage survival and Treg recruitment via the CCL20/CCR6 axis in human hepatocellular carcinoma
Lipid droplet accumulation mediates macrophage survival and Treg recruitment via the CCL20/CCR6 axis in human hepatocellular carcinoma
Metabolic changes play a crucial role in determining the status and function of macrophages, but how lipid reprogramming i...
BAG6 restricts pancreatic cancer progression by suppressing the release of IL33-presenting extracellular vesicles and the activation of mast cells
BAG6 restricts pancreatic cancer progression by suppressing the release of IL33-presenting extracellular vesicles and the activation of mast cells
Recent studies reveal a critical role of tumor cell-released extracellular vesicles (EVs) in pancreatic cancer (PC) progre...
Targeting the intestinal circadian clock by meal timing ameliorates gastrointestinal inflammation
Targeting the intestinal circadian clock by meal timing ameliorates gastrointestinal inflammation
The expression of clock genes has been observed to be impaired in biopsies from patients with inflammatory bowel disease (...
Innate and adaptive immune responses that control lymph-borne viruses in the draining lymph node
Innate and adaptive immune responses that control lymph-borne viruses in the draining lymph node
The interstitial fluids in tissues are constantly drained into the lymph nodes (LNs) as lymph through afferent lymphatic v...
Exportin 1 governs the immunosuppressive functions of myeloid-derived suppressor cells in tumors through ERK1/2 nuclear export
Exportin 1 governs the immunosuppressive functions of myeloid-derived suppressor cells in tumors through ERK1/2 nuclear export
Myeloid-derived suppressor cells (MDSCs) are a main driver of immunosuppression in tumors. Understanding the mechanisms th...
SENP6 restricts the IFN-I-induced signaling pathway and antiviral activity by deSUMOylating USP8
SENP6 restricts the IFN-I-induced signaling pathway and antiviral activity by deSUMOylating USP8
Type I interferon (IFN-I) exhibits broad-spectrum antiviral properties and is commonly employed in clinical for the treatm...
Depleting profibrotic macrophages using bioactivated in vivo assembly peptides ameliorates kidney fibrosis
Depleting profibrotic macrophages using bioactivated in vivo assembly peptides ameliorates kidney fibrosis
Managing renal fibrosis is challenging owing to the complex cell signaling redundancy in diseased kidneys. Renal fibrosis ...
Chaperone- and PTM-mediated activation of IRF1 tames radiation-induced cell death and the inflammatory response
Chaperone- and PTM-mediated activation of IRF1 tames radiation-induced cell death and the inflammatory response
The key role of structural cells in immune modulation has been revealed with the advent of single-cell multiomics, but the...
PARP7 and nucleic acid-driven oncosuppression
PARP7 and nucleic acid-driven oncosuppression
The LG lab is/has been supported (as a PI, unless otherwise indicated) by one NIH R01 grant (#CA271915), by two Breakthrou...
TL1A and IL-18 synergy promotes GM-CSF-dependent thymic granulopoiesis in mice
TL1A and IL-18 synergy promotes GM-CSF-dependent thymic granulopoiesis in mice
Acute systemic inflammation critically alters the function of the immune system, often promoting myelopoiesis at the expen...
HIF-1α and MIF enhance neutrophil-driven type 3 immunity and chondrogenesis in a murine spondyloarthritis model
HIF-1α and MIF enhance neutrophil-driven type 3 immunity and chondrogenesis in a murine spondyloarthritis model
The hallmarks of spondyloarthritis (SpA) are type 3 immunity-driven inflammation and new bone formation (NBF). Macrophage ...
8th Sino-German symposium on immunology: fostering mutual trust and collaborative endeavors for advancing immunological science
8th Sino-German symposium on immunology: fostering mutual trust and collaborative endeavors for advancing immunological science
Wang L, Wen M, Cao X. Nuclear hnRNPA2B1 initiates and amplifies the innate immune response to DNA viruses. Science. 2019;3...
UDPG: Maintaining the true nature of sugar
UDPG: Maintaining the true nature of sugar
Glucose is an essential source of energy in human diets. After ingestion, blood glucose levels rapidly increase but soon r...
Vitamin D-dependent microbiota-enhancing tumor immunotherapy
Vitamin D-dependent microbiota-enhancing tumor immunotherapy
Research in the author’s laboratory is supported by the Ministry of Science and Innovation and the Spanish Research Agency...
Legacy of the discovery of the T-cell receptor: 40 years of shaping basic immunology and translational work to develop novel therapies
Legacy of the discovery of the T-cell receptor: 40 years of shaping basic immunology and translational work to develop novel therapies
Hedrick SM, Cohen DI, Nielsen EA, Davis MM. Isolation of cDNA clones encoding T cell-specific membrane-associated proteins...
TRIM33 plays a critical role in regulating dendritic cell differentiation and homeostasis by modulating Irf8 and Bcl2l11 transcription
TRIM33 plays a critical role in regulating dendritic cell differentiation and homeostasis by modulating Irf8 and Bcl2l11 transcription
The development of distinct dendritic cell (DC) subsets, namely, plasmacytoid DCs (pDCs) and conventional DC subsets (cDC1...
Correction: Defining two subpopulations of marginal zone B cells
Reference 5 has been corrected from “YKS Lee, HW Lee, WJ Oh, HG Hong, D Ariyaratne, SJ Im, et al. Two Distinct Subpopulati...
Targeting STING in dendritic cells alleviates psoriatic inflammation by suppressing IL-17A production
Targeting STING in dendritic cells alleviates psoriatic inflammation by suppressing IL-17A production
Psoriasis is a common chronic inflammatory skin disease driven by the aberrant activation of dendritic cells (DCs) and T c...
The protective roles of integrin α4β7 and Amphiregulin-expressing innate lymphoid cells in lupus nephritis
The protective roles of integrin α4β7 and Amphiregulin-expressing innate lymphoid cells in lupus nephritis
Type 2 innate lymphoid cells (ILC2s) have emerged as key regulators of the immune response in renal inflammatory diseases ...
Neutrophils disrupt B-1a cell homeostasis by targeting Siglec-G to exacerbate sepsis
Neutrophils disrupt B-1a cell homeostasis by targeting Siglec-G to exacerbate sepsis
B-1a cells, an innate-like cell population, are crucial for pathogen defense and the regulation of inflammation through th...
Bridging the gap with multispecific immune cell engagers in cancer and infectious diseases
Bridging the gap with multispecific immune cell engagers in cancer and infectious diseases
By binding to multiple antigens simultaneously, multispecific antibodies are expected to substantially improve both the ac...
The role of plasmacytoid dendritic cells (pDCs) in immunity during viral infections and beyond
The role of plasmacytoid dendritic cells (pDCs) in immunity during viral infections and beyond
Type I and III interferons (IFNs) are essential for antiviral immunity and act through two different but complimentary pat...
Liver kinase B1 (LKB1) staves off γδ T-cell-mediated autoimmune liver disease
Liver kinase B1 (LKB1) staves off γδ T-cell-mediated autoimmune liver disease
Xiao Z, Wang S, Luo L, Lv W, Feng P, Sun Y, et al. Lkb1 orchestrates gd T cell metabolic and functional fitness to control...
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