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A special RELationship between sugar and tumor-infiltrating regulatory T cells
A special RELationship between sugar and tumor-infiltrating regulatory T cells
In this context of Cellular and Molecular Immunology, Sharma and coworkers r...
Effective immunosurveillance of clonally expanded mammary aneuploid cells
Effective immunosurveillance of clonally expanded mammary aneuploid cells
The LG lab is/has been supported (as a PI unless otherwise indicated) by one NIH R01 grant (#CA271915), by two Breakthroug...
MYO1F regulates T-cell activation and glycolytic metabolism by promoting the acetylation of GAPDH
MYO1F regulates T-cell activation and glycolytic metabolism by promoting the acetylation of GAPDH
Proper cellular metabolism in T cells is critical for a productive immune response. However, when dysregulated by intrinsi...
The antitumor activity of TGFβ-specific T cells is dependent on IL-6 signaling
The antitumor activity of TGFβ-specific T cells is dependent on IL-6 signaling
Although interleukin (IL)-6 is considered immunosuppressive and tumor-promoting, emerging evidence suggests that it may su...
Neutrophils in cancer: from biology to therapy
Neutrophils in cancer: from biology to therapy
The view of neutrophils has shifted from simple phagocytic cells, whose main function is to kill pathogens, to very comple...
Esophageal ILC2s mediate abnormal epithelial remodeling in eosinophilic esophagitis via Areg-EGFR signaling
Esophageal ILC2s mediate abnormal epithelial remodeling in eosinophilic esophagitis via Areg-EGFR signaling
Eosinophilic esophagitis (EoE) is a chronic allergic disorder characterized by eosinophilia and epithelial thickening, res...
Immunogenicity of cell death and cancer immunotherapy with immune checkpoint inhibitors
Immunogenicity of cell death and cancer immunotherapy with immune checkpoint inhibitors
While immunotherapy with immune checkpoint inhibitors (ICIs) has revolutionized the clinical management of various maligna...
Children exhibit a robust B-cell response to Omicron BA.2 after breakthrough infection with limited influence from the original antigenic sin
Children exhibit a robust B-cell response to Omicron BA.2 after breakthrough infection with limited influence from the original antigenic sin
Dowell AC, Lancaster T, Bruton R, Ireland G, Bentley C, Sylla P, et al. Immunological imprinting of humoral immunity to SA...
Dysregulation in keratinocytes drives systemic lupus erythematosus onset
Dysregulation in keratinocytes drives systemic lupus erythematosus onset
Systemic lupus erythematosus (SLE) is a complex, multiorgan autoimmune disorder. Although it is widely believed that SLE o...
Dynamic O-GlcNAcylation governs long-range chromatin interactions in V(D)J recombination during early B-cell development
Dynamic O-GlcNAcylation governs long-range chromatin interactions in V(D)J recombination during early B-cell development
V(D)J recombination secures the production of functional immunoglobulin (Ig) genes and antibody diversity during the early...
Gasdermin D unlocks metabolic pathways to enhance tissue regeneration
Gasdermin D unlocks metabolic pathways to enhance tissue regeneration
Chi Z, Chen S, Yang D, Cui W, Lu Y, Wang Z, et al. Gasdermin D-mediated metabolic crosstalk promotes tissue repair. Nature...
Alternative mRNA polyadenylation regulates macrophage hyperactivation via the autophagy pathway
Alternative mRNA polyadenylation regulates macrophage hyperactivation via the autophagy pathway
Macrophage hyperactivation is a hallmark of inflammatory diseases, yet the role of alternative polyadenylation (APA) of mR...
Metabolic rewiring controlled by HIF-1α tunes IgA-producing B-cell differentiation and intestinal inflammation
Metabolic rewiring controlled by HIF-1α tunes IgA-producing B-cell differentiation and intestinal inflammation
Germinal centers where B cells undergo clonal expansion and antibody affinity maturation are hypoxic microenvironments. Ho...
Critical and differential roles of eIF4A1 and eIF4A2 in B-cell development and function
Critical and differential roles of eIF4A1 and eIF4A2 in B-cell development and function
Eukaryotic initiation factor 4 A (eIF4A) plays critical roles during translation initiation of cellular mRNAs by for...
Targeting of TAMs: can we be more clever than cancer cells?
Targeting of TAMs: can we be more clever than cancer cells?
With increasing incidence and geography, cancer is one of the leading causes of death, reduced quality of life and disabil...
Targeting GSDME-mediated macrophage polarization for enhanced antitumor immunity in hepatocellular carcinoma
Targeting GSDME-mediated macrophage polarization for enhanced antitumor immunity in hepatocellular carcinoma
Despite the notable efficacy of anti-PD1 therapy in the management of hepatocellular carcinoma (HCC) patients, resistance ...
Glut3 promotes cellular O-GlcNAcylation as a distinctive tumor-supportive feature in Treg cells
Glut3 promotes cellular O-GlcNAcylation as a distinctive tumor-supportive feature in Treg cells
Regulatory T cells (Tregs) establish dominant immune tolerance but obstruct tumor immune surveillance, warranting context-...
Specific ECM degradation potentiates the antitumor activity of CAR-T cells in solid tumors
Specific ECM degradation potentiates the antitumor activity of CAR-T cells in solid tumors
Although major progress has been made in the use of chimeric antigen receptor (CAR)-T-cell therapy for hematological malig...
Ubiquitin regulatory X (UBX) domain-containing protein 6 is essential for autophagy induction and inflammation control in macrophages
Ubiquitin regulatory X (UBX) domain-containing protein 6 is essential for autophagy induction and inflammation control in macrophages
Ubiquitin regulatory X (UBX) domain-containing protein 6 (UBXN6) is an essential cofactor for the activity of the valosin-...
Age-associated imbalance in immune cell regeneration varies across individuals and arises from a distinct subset of stem cells
Age-associated imbalance in immune cell regeneration varies across individuals and arises from a distinct subset of stem cells
The age-associated decline in immunity manifests as imbalanced adaptive and innate immune cells, which originate from the ...
Kynurenine-AhR reduces T-cell infiltration and induces a delayed T-cell immune response by suppressing the STAT1-CXCL9/CXCL10 axis in tuberculosis
Kynurenine-AhR reduces T-cell infiltration and induces a delayed T-cell immune response by suppressing the STAT1-CXCL9/CXCL10 axis in tuberculosis
Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), is a critical global health issue that is complicated by the abi...
No more LAGging behind PD-1: uncovering the unique role of LAG-3 in T-cell exhaustion
No more LAGging behind PD-1: uncovering the unique role of LAG-3 in T-cell exhaustion
Zander R, Cui W. Exhausted CD8(+) T cells face a developmental fork in the road. Trends Immunol. 2023;44:276–86.Article  ...
CD30 influences germinal center B-cell dynamics and the expansion of IgG1-switched B cells
CD30 influences germinal center B-cell dynamics and the expansion of IgG1-switched B cells
Initially, identified as a Hodgkin lymphoma marker, CD30 was subsequently detected on a subset of human B cells within and...
Regulation of CD8+ T cells by lipid metabolism in cancer progression
Regulation of CD8+ T cells by lipid metabolism in cancer progression
Dysregulation of lipid metabolism is a key characteristic of the tumor microenvironment, where tumor cells utilize lipids ...
Macrophage diversity in cancer dissemination and metastasis
Macrophage diversity in cancer dissemination and metastasis
Invasion and metastasis are hallmarks of cancer. In addition to the well-recognized hematogenous and lymphatic pathways of...
Immunotherapy for glioblastoma: current state, challenges, and future perspectives
Immunotherapy for glioblastoma: current state, challenges, and future perspectives
Glioblastoma (GBM) is an aggressive and lethal type of brain tumor in human adults. The standard of care offers minimal cl...
Author Correction: Fatty acid metabolism constrains Th9 cell differentiation and antitumor immunity via the modulation of retinoic acid receptor signaling
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Type 17 immunity: novel insights into intestinal homeostasis and autoimmune pathogenesis driven by gut-primed T cells 
Type 17 immunity: novel insights into intestinal homeostasis and autoimmune pathogenesis driven by gut-primed T cells 
The IL-23 signaling pathway in both innate and adaptive immune cells is vital for orchestrating type 17 immunity, which is...
Silencing of SIRPα enhances the antitumor efficacy of CAR-M in solid tumors
Silencing of SIRPα enhances the antitumor efficacy of CAR-M in solid tumors
The potential of macrophage-mediated phagocytosis as a cancer treatment is promising. Blocking the CD47–SIRPα i...
The TET3 inflammasome senses unique long HSV-1 proteins for virus particle budding from the nucleus
The TET3 inflammasome senses unique long HSV-1 proteins for virus particle budding from the nucleus
Inflammasomes play important roles in resisting infections caused by various pathogens. HSV-1 is a highly contagious virus...
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