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Orthopedic Surgery in Osteogenesis Imperfecta in Adults
Orthopedic Surgery in Osteogenesis Imperfecta in Adults
Osteogenesis imperfecta is a genetic disorder, mainly characterized by bone fragility. In adult with osteogenesis imperfec...
Adapting to Adulthood: A Review of Transition Strategies for Osteogenesis Imperfecta
Adapting to Adulthood: A Review of Transition Strategies for Osteogenesis Imperfecta
Osteogenesis Imperfecta (OI), known as “brittle bone disease,” presents a rare genetic disorder characterized ...
The Role of the European Reference Network for Rare Bone Diseases (ERN BOND) and European Registries for Rare Bone and Mineral Conditions (EuRR-Bone) in the Governance of the Management of Rare Bone and Mineral Diseases
The Role of the European Reference Network for Rare Bone Diseases (ERN BOND) and European Registries for Rare Bone and Mineral Conditions (EuRR-Bone) in the Governance of the Management of Rare Bone and Mineral Diseases
Rare diseases (RDs) bear a significant challenge to individuals, healthcare systems, and societies. The European reference...
The Lacunocanalicular Network is Denser in C57BL/6 Compared to BALB/c Mice
The Lacunocanalicular Network is Denser in C57BL/6 Compared to BALB/c Mice
The lacunocanalicular network (LCN) is an intricate arrangement of cavities (lacunae) and channels (canaliculi), which per...
Influence of Ethnicity and Deprivation on Occurrence of Paget’S Disease in Greater Manchester, UK
Influence of Ethnicity and Deprivation on Occurrence of Paget’S Disease in Greater Manchester, UK
There is important variation in the occurrence of Paget’s disease in different regions and populations. There are th...
Long-Term Reproducibility of BMD-Measurements with Clinical QCT Using Simultaneous and Asynchronous Calibration Methods and Different Measurement and Reconstruction Protocols
Long-Term Reproducibility of BMD-Measurements with Clinical QCT Using Simultaneous and Asynchronous Calibration Methods and Different Measurement and Reconstruction Protocols
Osteoporosis is underdiagnosed and undertreated. To improve timely fracture risk assessment optimized densitometry methods...
High SHBG and Low Bioavailable Testosterone are Strongly Causally Associated with Increased Forearm Fracture Risk in Women: An MR Study Leveraging Novel Female-Specific Data
High SHBG and Low Bioavailable Testosterone are Strongly Causally Associated with Increased Forearm Fracture Risk in Women: An MR Study Leveraging Novel Female-Specific Data
The effects of androgens on women’s bone health are not fully understood. Mendelian randomization (MR) studies using...
Sex-Specific Association Patterns of Bone Microstructure and Lower Leg Arterial Calcification
Sex-Specific Association Patterns of Bone Microstructure and Lower Leg Arterial Calcification
In conversations about bone loss and the importance of calcium homeostasis, patients frequently inquire about the associat...
Long-Term Follow-up After Ovariectomy Reveals Correlations Between Bone Marrow Adiposity and Trabecular Bone Quality in the Proximal Metaphysis of Tibiae in Rats
Long-Term Follow-up After Ovariectomy Reveals Correlations Between Bone Marrow Adiposity and Trabecular Bone Quality in the Proximal Metaphysis of Tibiae in Rats
This study aimed to evaluate the correlation between BMAT and bone quality, describe the long-term effects of ovariectomy ...
Short-Term Changes in Bone Metabolism Among Transgender Men Starting Gender-Affirming Hormone Therapy: A Systematic Review and Meta-analysis
Short-Term Changes in Bone Metabolism Among Transgender Men Starting Gender-Affirming Hormone Therapy: A Systematic Review and Meta-analysis
Transgender and gender diverse individuals experience a gender identity that differs from the sex assigned at birth. Some ...
Causes of Musculoskeletal Pain in Paget’s Disease of Bone
Causes of Musculoskeletal Pain in Paget’s Disease of Bone
Paget’s disease of bone (PDB) is characterised by increased and disorganised bone remodelling leading to various com...
Effect of Fibroblast Growth Factor (FGF) 19 and 21 on Hip Geometry and Strength in Post-menopausal Osteoporosis (PMO)
Effect of Fibroblast Growth Factor (FGF) 19 and 21 on Hip Geometry and Strength in Post-menopausal Osteoporosis (PMO)
Fibroblast Growth Factor (FGF) receptor signalling is important for skeletal development. The FGF19 subfamily which includ...
Zebrafish Models for Skeletal and Extraskeletal Osteogenesis Imperfecta Features: Unveiling Pathophysiology and Paving the Way for Drug Discovery
Zebrafish Models for Skeletal and Extraskeletal Osteogenesis Imperfecta Features: Unveiling Pathophysiology and Paving the Way for Drug Discovery
In the last decades, the easy genetic manipulation, the external fertilization, the high percentage of homology with human...
MTX Osteopathy Versus Osteoporosis Including Response to Treatment Data—A Retrospective Single Center Study Including 172 Patients
MTX Osteopathy Versus Osteoporosis Including Response to Treatment Data—A Retrospective Single Center Study Including 172 Patients
MTX is an effective and widely used immunomodulatory drug for rheumatoid diseases. MTX osteopathy is a very rare and speci...
Preventing OsteoPorosis in Spinal Cord Injury (POPSCI) Study—Early Zoledronic Acid Infusion in Patients with Acute Spinal Cord Injury
Preventing OsteoPorosis in Spinal Cord Injury (POPSCI) Study—Early Zoledronic Acid Infusion in Patients with Acute Spinal Cord Injury
Accelerated sub-lesional bone loss is common in the first 2–3 years after traumatic spinal cord injury (TSC...
Early-Onset Osteoporosis: Molecular Analysis in Large Cohort and Focus on the PLS3 Gene
Early-Onset Osteoporosis: Molecular Analysis in Large Cohort and Focus on the PLS3 Gene
Osteoporosis is a skeletal disorder characterized by abnormal bone microarchitecture and low bone mineral density (BMD), r...
Fermented Dairy Products, Musculoskeletal and Mental Health in Older Adults: is There Evidence to Support Benefits that go Beyond Those of Non-Fermented Dairy Products?
Fermented Dairy Products, Musculoskeletal and Mental Health in Older Adults: is There Evidence to Support Benefits that go Beyond Those of Non-Fermented Dairy Products?
Fermented dairy products have recently gained popularity due to their purported health benefits, nevertheless, their role ...
Irisin Ameliorates Muscle Atrophy by Inhibiting the Upregulation of the Ubiquitin‒Proteasome System in Chronic Kidney Disease
Irisin Ameliorates Muscle Atrophy by Inhibiting the Upregulation of the Ubiquitin‒Proteasome System in Chronic Kidney Disease
Muscle atrophy is a common complication of chronic kidney disease (CKD). Irisin, a novel muscle cytokine, protects against...
Dental Abnormalities in Osteogenesis Imperfecta: A Systematic Review
Dental Abnormalities in Osteogenesis Imperfecta: A Systematic Review
Osteogenesis imperfecta (OI) is a rare genetic disorder characterized by fragile bones and skeletal deformities. Individua...
Association Between Dietary Acid Load and Grip Strength in Adults 50 Years and Older: A Cross-Sectional Study
Association Between Dietary Acid Load and Grip Strength in Adults 50 Years and Older: A Cross-Sectional Study
Minimal data exist on whether the acid–base balance of the diet is linked to muscle strength. The aim of th...
Exogenous Angiotensin-(1–7) Provides Protection Against Inflammatory Bone Resorption and Osteoclastogenesis by Inhibition of TNF-α Expression in Macrophages
Exogenous Angiotensin-(1–7) Provides Protection Against Inflammatory Bone Resorption and Osteoclastogenesis by Inhibition of TNF-α Expression in Macrophages
Renin–angiotensin–aldosterone system plays a crucial role in the regulation of blood pressure and fluid homeos...
Osteocyte Sptbn1 Deficiency Alters Cell Survival and Mechanotransduction Following Formation of Plasma Membrane Disruptions (PMD) from Mechanical Loading
Osteocyte Sptbn1 Deficiency Alters Cell Survival and Mechanotransduction Following Formation of Plasma Membrane Disruptions (PMD) from Mechanical Loading
We and others have shown that application of high-level mechanical loading promotes the formation of transient plasma memb...
Sex-Specific Association of Clinical Parameters and Components of Femoral Bone Quality in Patients Undergoing Total Hip Arthroplasty
Sex-Specific Association of Clinical Parameters and Components of Femoral Bone Quality in Patients Undergoing Total Hip Arthroplasty
Poor bone quality is a critical factor associated with an increased risk of complications after total hip arthroplasty (TH...
Effects of Cannabidiol on Bone Quality in Ovariectomized Rats
Effects of Cannabidiol on Bone Quality in Ovariectomized Rats
The incidence of osteoporosis and related fractures increases significantly with age, impacting public health and associat...
Saturation Effect of Lipid Accumulation Product (LAP) Index on Spinal Bone Mineral Density: A Population-Based Study
Saturation Effect of Lipid Accumulation Product (LAP) Index on Spinal Bone Mineral Density: A Population-Based Study
Lipid accumulation product (LAP) has a positive effect on spinal bone mineral density (BMD). However, once LAP levels exce...
Bone Quality and Mineralization and Effects of Treatment in Osteogenesis Imperfecta
Bone Quality and Mineralization and Effects of Treatment in Osteogenesis Imperfecta
Osteogenesis imperfecta (OI) is a rare congenital bone dysplasia characterized by high fracture rates and broad variations...
Morinda Officinalis Polysaccharides Inhibit Osteoclast Differentiation by Regulating miR-214-3p/NEDD4L in Postmenopausal Osteoporosis Mice
Morinda Officinalis Polysaccharides Inhibit Osteoclast Differentiation by Regulating miR-214-3p/NEDD4L in Postmenopausal Osteoporosis Mice
To investigate the potential mechanism of Morinda officinalis F. C. How polysaccharides (MOPs) in regulating osteoclast di...
Deficiency of Trps1 in Cementoblasts Impairs Cementogenesis and Tooth Root Formation
Deficiency of Trps1 in Cementoblasts Impairs Cementogenesis and Tooth Root Formation
Cementum is the least studied of all mineralized tissues and little is known about mechanisms regulating its formation. Th...
Cardiac Biomarkers are Associated with Incident Fracture Risk in Advanced Chronic Kidney Disease
Cardiac Biomarkers are Associated with Incident Fracture Risk in Advanced Chronic Kidney Disease
Cardiovascular disease is associated with increased fracture risk in the general population. Few data exist on the associa...
Skeletal and Non-skeletal Phenotypes in Children with Osteogenesis Imperfecta
Skeletal and Non-skeletal Phenotypes in Children with Osteogenesis Imperfecta
Although fractures are the defining characteristic of osteogenesis imperfecta (OI), the disorder affects many tissues. Her...
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