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Xuanhong Dingchuan Tang suppresses bronchial asthma inflammation via the microRNA-107-3p/PTGS2/MAPK axis
Xuanhong Dingchuan Tang suppresses bronchial asthma inflammation via the microRNA-107-3p/PTGS2/MAPK axis
This study aimed to investigate the mechanism of Xuanhong Dingchuan Tang (XHDCT) in delaying bronchial asthma inflammation...
Integration of osimertinib-targeted EGFR gene-associated differential gene expression in constructing a prognostic model for lung adenocarcinoma
Integration of osimertinib-targeted EGFR gene-associated differential gene expression in constructing a prognostic model for lung adenocarcinoma
Lung adenocarcinoma (LUAD) is one of the deadliest cancers. Epidermal growth factor receptor-tyrosine kinase inhibitor (EG...
Serine related gene CCT6A promotes metastasis of hepatocellular carcinoma via interacting with RPS3
Serine related gene CCT6A promotes metastasis of hepatocellular carcinoma via interacting with RPS3
Metastasis is responsible for approximately 90% of lethality from solid tumors. Metabolic abnormalities are one of the key...
Gene clusters-based pathway enrichment analysis identifies four pan-cancer subtypes with distinct molecular and clinical features
Gene clusters-based pathway enrichment analysis identifies four pan-cancer subtypes with distinct molecular and clinical features
Pathways-based clustering methods have been proposed to explore tumor heterogeneity. However, such methods are currently d...
Decoding the role of durum wheat ascorbate peroxidase TdAPX7B-2 in abiotic stress response
Decoding the role of durum wheat ascorbate peroxidase TdAPX7B-2 in abiotic stress response
APX proteins are H2O2-scavenging enzymes induced during oxidative stress. In the first part of this study, we provided an ...
TBP activates DCBLD1 transcription to promote cell cycle progression in cervical cancer
TBP activates DCBLD1 transcription to promote cell cycle progression in cervical cancer
Discoidin, CUB, and LCCL domain-containing (DCBLD) proteins have been associated with poor prognosis of human cancers. Thi...
Tracing the intraspecies expansion of glyoxalase genes and their expanding roles across the genus Oryza
Tracing the intraspecies expansion of glyoxalase genes and their expanding roles across the genus Oryza
The genus Oryza is of utmost importance to human civilization as two of its species became agronomically productive and wi...
Transcriptome-wide investigation and functional characterization reveal a terpene synthase involved in γ-terpinene biosynthesis in Monarda citriodora
Transcriptome-wide investigation and functional characterization reveal a terpene synthase involved in γ-terpinene biosynthesis in Monarda citriodora
Monarda citriodora Cerv. ex Lag. is a rich source of industrially important compounds like γ-terpinene, carvacrol, th...
The role of disulfidptosis-associated LncRNA-LINC01137 in Osteosarcoma Biology and its regulatory effects on macrophage polarization
The role of disulfidptosis-associated LncRNA-LINC01137 in Osteosarcoma Biology and its regulatory effects on macrophage polarization
The objective of this research is to investigate the function of long non-coding RNA (lncRNA) associated with disulfidptos...
Breaking the yield-quality tradeoff: OsNLP3 in rice
Breaking the yield-quality tradeoff: OsNLP3 in rice
A recent study by Sun et al. OsNLP3 enhances grain weight and reduces grain chalkiness in rice sheds new insight on the cr...
Can nanotechnology and genomics innovations trigger agricultural revolution and sustainable development?
Can nanotechnology and genomics innovations trigger agricultural revolution and sustainable development?
At the dawn of new millennium, policy makers and researchers focused on sustainable agricultural growth, aiming for food s...
Time-course RNA sequencing reveals high similarity in mRNAome between hepatic stellate cells activated by agalactosyl IgG and TGF-β1
Time-course RNA sequencing reveals high similarity in mRNAome between hepatic stellate cells activated by agalactosyl IgG and TGF-β1
Previous studies have demonstrated the clinical relevance of aberrant serum immunoglobulin G (IgG) N-glycomic profiles in ...
Non-coding RNA notations, regulations and interactive resources
Non-coding RNA notations, regulations and interactive resources
An increasing number of non-coding RNAs (ncRNAs) are found to have roles in gene expression and cellular regulations. Howe...
BHLHE40-mediated transcriptional activation of GRIN2D in gastric cancer is involved in metabolic reprogramming
BHLHE40-mediated transcriptional activation of GRIN2D in gastric cancer is involved in metabolic reprogramming
Gastric cancer (GC) is the third leading cause of death in developed countries. The reprogramming of energy metabolism rep...
pSATdb 2.0: a database of organellar common, polymorphic, and unique microsatellites
pSATdb 2.0: a database of organellar common, polymorphic, and unique microsatellites
Microsatellites, or simple sequence repeats (SSRs), are repetitive DNA sequences typically composed of 1–6 nucleotid...
Drought-tolerant wheat for enhancing global food security
Drought-tolerant wheat for enhancing global food security
Wheat is among the most produced grain crops of the world and alone provides a fifth of the world’s calories and pro...
Multi-omics analysis of the biological function of the VEGF family in colon adenocarcinoma
Multi-omics analysis of the biological function of the VEGF family in colon adenocarcinoma
The vascular endothelial growth factor (VEGF) family plays a crucial role in cancer progression, but the prognostic signif...
Harnessing natural compounds to modulate miRNAs in breast cancer therapy
Harnessing natural compounds to modulate miRNAs in breast cancer therapy
Breast cancer’s complexity and heterogeneity continue to present significant challenges in its treatment and managem...
Exploring the clinical potential of circulating LncRNAs in breast cancer: insights into primary signaling pathways and therapeutic interventions
Exploring the clinical potential of circulating LncRNAs in breast cancer: insights into primary signaling pathways and therapeutic interventions
Breast cancer (BC) occupies the top spot among women on a global scale. The tumor has a significant degree of heterogeneit...
CRISPR/Cas technology: fueling the future of Biofuel production with sugarcane
CRISPR/Cas technology: fueling the future of Biofuel production with sugarcane
The objective of present review is to provide a scientific overview of sugarcane as a potential feedstock for biofuel and ...
Integration of CRISPR/Cas9 with multi-omics technologies to engineer secondary metabolite productions in medicinal plant: Challenges and Prospects
Integration of CRISPR/Cas9 with multi-omics technologies to engineer secondary metabolite productions in medicinal plant: Challenges and Prospects
Plants acts as living chemical factories that may create a large variety of secondary metabolites, most of which ...
Breast cancer genomic analyses reveal genes, mutations, and signaling networks
Breast cancer genomic analyses reveal genes, mutations, and signaling networks
Breast cancer (BC) is the most commonly diagnosed cancer and the predominant cause of death in women. BC is a complex diso...
Circular RNA circ_0022707 impedes the progression of preeclampsia via the miR-3135b/GHR/PI3K/Akt axis
Circular RNA circ_0022707 impedes the progression of preeclampsia via the miR-3135b/GHR/PI3K/Akt axis
Preeclampsia (PE) is a severe pregnancy complication linked to maternal and fetal health, yet its underlying causes and pa...
GWAS for identification of genomic regions and candidate genes in vegetable crops
GWAS for identification of genomic regions and candidate genes in vegetable crops
Genome-wide association Studies (GWAS), initially developed for human genetics, have been highly effective in plant resear...
Upregulation of Cullin1 neddylation promotes glycolysis and M1 polarization of macrophage via NF-κB p65 pathway in sepsis
Upregulation of Cullin1 neddylation promotes glycolysis and M1 polarization of macrophage via NF-κB p65 pathway in sepsis
This study aimed to explore the underlying mechanism of neddylation in macrophage polarization during sepsis. A mouse mode...
Natural compounds targeting miRNAs: a novel approach in oral cancer therapy
Natural compounds targeting miRNAs: a novel approach in oral cancer therapy
Oral cancer (OC) is a significant global health issue, with high rates of both mortality and morbidity. Conventional treat...
Genome-wide association study reveals effect of nsSNPs on candidate genes in rice during iron deficiency
Genome-wide association study reveals effect of nsSNPs on candidate genes in rice during iron deficiency
Resource-poor areas with moisture deficit lands following aerobic and direct seeded rice (DSR) methods of cultivation face...
CRISPR/Cas9 mediated genome editing for crop improvement against Abiotic stresses: current trends and prospects
CRISPR/Cas9 mediated genome editing for crop improvement against Abiotic stresses: current trends and prospects
Abiotic stresses associated with climate change, such as heat, cold, salinity, and drought, represent a serious threat to ...
PTP1B inhibitor alleviates deleterious septic lung injury through Src signaling
PTP1B inhibitor alleviates deleterious septic lung injury through Src signaling
Septic lung injury is an unmet clinical challenge due to its high mortality, and there is a lack of effective treatment. A...
ANPS: machine learning based server for identification of anti-nutritional proteins in plants
ANPS: machine learning based server for identification of anti-nutritional proteins in plants
Anti-nutrient factors are inherently present in almost all major crops, which impede the absorption of crucial vitamins an...
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