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Engineering circular RNA for molecular and metabolic reprogramming
Engineering circular RNA for molecular and metabolic reprogramming
The role of messenger RNA (mRNA) in biological systems is extremely versatile. However, it’s extremely short half-li...
Integrated multi-omics analysis and machine learning to refine molecular subtypes, prognosis, and immunotherapy in lung adenocarcinoma
Integrated multi-omics analysis and machine learning to refine molecular subtypes, prognosis, and immunotherapy in lung adenocarcinoma
Lung adenocarcinoma (LUAD) has a malignant characteristic that is highly aggressive and prone to metastasis. There is stil...
RUNX3 exerts tumor-suppressive role through inhibiting EXOSC4 expression
RUNX3 exerts tumor-suppressive role through inhibiting EXOSC4 expression
Breast cancer severely affects women health. 70% of breast cancer are estrogen receptor positive. Breast cancer stem cells...
Reviving resilience: MEcPP-mediated ASK1-IMPα-9-TRP2 stress-responsive module
Reviving resilience: MEcPP-mediated ASK1-IMPα-9-TRP2 stress-responsive module
Chloroplasts are not only critical photosynthesis sites in plants, but they also participate in plastidial retrograde sign...
Navigating the intricacies of RT-qPCR data analysis in gene expression studies
Navigating the intricacies of RT-qPCR data analysis in gene expression studies
Arya M, Shergill IS, Williamson M et al (2005) Basic principles of real-time quantitative PCR. Expert Rev Mol Diagn 5:209–...
Pharmacological inhibition of RUNX1 reduces infarct size after acute myocardial infarction in rats and underlying mechanism revealed by proteomics implicates repressed cathepsin levels
Pharmacological inhibition of RUNX1 reduces infarct size after acute myocardial infarction in rats and underlying mechanism revealed by proteomics implicates repressed cathepsin levels
Myocardial infarction (MI) results in prolonged ischemia and the subsequent cell death leads to heart failure which is lin...
Iodine-125 seed inhibits proliferation and promotes apoptosis of cholangiocarcinoma cells by inducing the ROS/p53 axis
Iodine-125 seed inhibits proliferation and promotes apoptosis of cholangiocarcinoma cells by inducing the ROS/p53 axis
With advances in radioactive particle implantation in clinical practice, Iodine-125 (125I) seed brachytherapy has emerged ...
Multi-omics analysis reveals mechanism of Schisandra chinensis lignans and acteoside on EMT in hepatoma cells via ERK1/2 pathway
Multi-omics analysis reveals mechanism of Schisandra chinensis lignans and acteoside on EMT in hepatoma cells via ERK1/2 pathway
Hepatocellular carcinoma (HCC), a globally common cancer, often presents late and shows high resistance to chemotherapy, r...
The CRISPR/Cas system as an antimicrobial resistance strategy in aquatic ecosystems
The CRISPR/Cas system as an antimicrobial resistance strategy in aquatic ecosystems
With the growing population, demand for food has dramatically increased, and fisheries, including aquaculture, are expecte...
Analysis of chloroplast genome characteristics and codon usage bias in 14 species of Annonaceae
Analysis of chloroplast genome characteristics and codon usage bias in 14 species of Annonaceae
For the study of species evolution, chloroplast gene expression, and transformation, the chloroplast genome is an invaluab...
Whole blood transcriptome signature predicts severe forms of COVID-19: Results from the COVIDeF cohort study
Whole blood transcriptome signature predicts severe forms of COVID-19: Results from the COVIDeF cohort study
COVID-19 is associated with heterogeneous outcome. Early identification of a severe progression of the disease is essentia...
Genome-wide identification and expression-pattern analysis of sulfate transporter (SULTR) gene family in cotton under multiple abiotic stresses and fiber development
Genome-wide identification and expression-pattern analysis of sulfate transporter (SULTR) gene family in cotton under multiple abiotic stresses and fiber development
Sulfate transporter (SULTR) proteins are in charge of the transport and absorption on sulfate substances, and have been re...
Assisting the analysis of insertions and deletions using regional allele frequencies
Assisting the analysis of insertions and deletions using regional allele frequencies
Accurate estimation of population allele frequency (AF) is crucial for gene discovery and genetic diagnostics. However, de...
Circular RNAs: a small piece in the heart failure puzzle
Circular RNAs: a small piece in the heart failure puzzle
Cardiovascular disease, specifically heart failure (HF), remains a significant concern in the realm of healthcare, necessi...
Genetic diversity and evolution of G12P[6] DS-1-like and G12P[9] AU-1-like Rotavirus strains in Brazil
Genetic diversity and evolution of G12P[6] DS-1-like and G12P[9] AU-1-like Rotavirus strains in Brazil
In the early 2000s, the global emergence of rotavirus (RVA) G12P[8] genotype was noted, while G12P[6] and G12P[9] combinat...
Genome editing: An insight into disease resistance, production efficiency, and biomedical applications in livestock
Genome editing: An insight into disease resistance, production efficiency, and biomedical applications in livestock
One of the primary concerns for the survival of the human species is the growing demand for food brought on by an increasi...
Unveiling the role of HIST2H2AC in stroke through single-cell and transcriptome analysis
Unveiling the role of HIST2H2AC in stroke through single-cell and transcriptome analysis
Stroke is a leading cause of death and disability, and genetic risk factors play a significant role in its development. Un...
Epidemiology, pathogenesis, immune evasion mechanism and vaccine development of porcine Deltacoronavirus
Epidemiology, pathogenesis, immune evasion mechanism and vaccine development of porcine Deltacoronavirus
Coronaviruses have been identified as pathogens of gastrointestinal and respiratory diseases in humans and various animal ...
Amlodipine inhibits Synaptotagmin-4’s oncogenic activity on gastric cancer proliferation by targeting calcium signaling
Amlodipine inhibits Synaptotagmin-4’s oncogenic activity on gastric cancer proliferation by targeting calcium signaling
Background: Gastric cancer (GC) remains a leading cause of cancer mortality globally. Synaptotagmin-4 (SYT4), a calcium-se...
HOXB9 promotes laryngeal squamous cell carcinoma progression by upregulating MMP12
HOXB9 promotes laryngeal squamous cell carcinoma progression by upregulating MMP12
Transcriptional factor HOXB9, a part of the HOX gene family, plays a crucial role in the development of diverse cancer typ...
Genetics aspect of vitamin C (Ascorbic Acid) biosynthesis and signaling pathways in fruits and vegetables crops
Genetics aspect of vitamin C (Ascorbic Acid) biosynthesis and signaling pathways in fruits and vegetables crops
Vitamin C, also known as ascorbic acid, is an essential nutrient that plays a critical role in many physiological processe...
Targeting nucleotide metabolic pathways in colorectal cancer by integrating scRNA-seq, spatial transcriptome, and bulk RNA-seq data
Targeting nucleotide metabolic pathways in colorectal cancer by integrating scRNA-seq, spatial transcriptome, and bulk RNA-seq data
Colorectal cancer is a malignant tumor of the digestive system originating from abnormal cell proliferation in the colon o...
Psilostachyin C reduces malignant properties of hepatocellular carcinoma cells by blocking CREBBP-mediated transcription of GATAD2B
Psilostachyin C reduces malignant properties of hepatocellular carcinoma cells by blocking CREBBP-mediated transcription of GATAD2B
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality globally. Many herbal medicines and their bi...
A review of the potential involvement of small RNAs in transgenerational abiotic stress memory in plants
A review of the potential involvement of small RNAs in transgenerational abiotic stress memory in plants
Crop production is increasingly threatened by the escalating weather events and rising temperatures associated with global...
CRISPR/Cas9 targeted mutations of OsDSG1 gene enhanced salt tolerance in rice
CRISPR/Cas9 targeted mutations of OsDSG1 gene enhanced salt tolerance in rice
Salinization is one of the leading causes of arable land shrinkage and rice yield decline, recently. Therefore, developing...
MATN2 overexpression suppresses tumor growth in ovarian cancer via PTEN/PI3K/AKT pathway
MATN2 overexpression suppresses tumor growth in ovarian cancer via PTEN/PI3K/AKT pathway
The incidence rate of developing ovarian cancer decreases over the years; however, mortality ranks top among malignancies ...
Exploring transient global transcriptional changes induced by ascorbic acid revealed via atKAS-seq profiling
Exploring transient global transcriptional changes induced by ascorbic acid revealed via atKAS-seq profiling
Transcription initiates the formation of single-stranded DNA (ssDNA) regions within the genome, delineating transcription ...
ASAPA: a bioinformatic pipeline based on Iso-Seq that identifies the links among alternative splicing, alternative transcription initiation and alternative polyadenylation
ASAPA: a bioinformatic pipeline based on Iso-Seq that identifies the links among alternative splicing, alternative transcription initiation and alternative polyadenylation
Background: Although the events associated with alternative splicing (AS), alternative polyadenylation (APA) and alternati...
TRIM5 as a promising diagnostic biomarker of hepatocellular carcinoma: integrated analysis and experimental validation
TRIM5 as a promising diagnostic biomarker of hepatocellular carcinoma: integrated analysis and experimental validation
The TRIM family is associated with the membrane, and its involvement in the progression, growth, and development of variou...
Comparative and phylogenetic analysis of the complete chloroplast genomes of ten Pittosporum species from East Asia
Comparative and phylogenetic analysis of the complete chloroplast genomes of ten Pittosporum species from East Asia
Pittosporum (Pittosporaceae) is famous as the ornamental and medical values, which is distributed tropical and subtropical...
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