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Genetic separation of chronic myeloid leukemia stem cells from normal hematopoietic stem cells at single-cell resolution
Genetic separation of chronic myeloid leukemia stem cells from normal hematopoietic stem cells at single-cell resolution
Chronic myeloid leukemia (CML) originates from hematopoietic stem cells (HSC), which is causally linked to a reciprocal tr...
Characterization of leukemia progression in the Cbfb-MYH11 knockin mice by single cell RNA sequencing
Characterization of leukemia progression in the Cbfb-MYH11 knockin mice by single cell RNA sequencing
Liu P, Tarle SA, Hajra A, Claxton DF, Marlton P, Freedman M, et al. Fusion between transcription factor CBF beta/PEBP2 bet...
Correction: Evaluation of bleeding events in patients receiving acalabrutinib therapy
The Ohio State University, Department of Pharmacy, Columbus, OH, USAPooja S. Kumar, Tracy Wiczer & Lindsay RosenThe Oh...
Does older age justify chlorambucil control arms for chronic lymphocytic leukemia clinical trials: a SEER-Medicare analysis
Does older age justify chlorambucil control arms for chronic lymphocytic leukemia clinical trials: a SEER-Medicare analysis
Ibrutinib has demonstrated prolonged responses in chronic lymphocytic leukemia (CLL) and changed the treatment paradigm fr...
Infectious complications after induction chemotherapy with FLAI(E) in newly diagnosed AML, omitting antibacterial prophylaxis
We recently read the very interesting paper by Walti et al. [1] in which they investigated infections occurred in Acute My...
UTX inactivation in germinal center B cells promotes the development of multiple myeloma with extramedullary disease
UTX inactivation in germinal center B cells promotes the development of multiple myeloma with extramedullary disease
UTX/KDM6A, a histone H3K27 demethylase and a key component of the COMPASS complex, is frequently lost or mutated in cancer...
Ibrutinib in combination with rituximab is highly effective in treatment of chronic lymphocytic leukemia patients with steroid refractory and relapsed autoimmune cytopenias
Ibrutinib in combination with rituximab is highly effective in treatment of chronic lymphocytic leukemia patients with steroid refractory and relapsed autoimmune cytopenias
Autoimmune hemolytic anemia (AIHA) and pure red cell aplasia (PRCA) are common complications of CLL. The optimal treatment...
Correction: Outstanding outcomes with two low intensity regimens in children with low-risk B-ALL: a report from COG AALL0932
Correction: Outstanding outcomes with two low intensity regimens in children with low-risk B-ALL: a report from COG AALL0932
Children’s National Health System, Washington, DC, USAReuven J. Schore & Anne L. AngiolilloGeorge Washington Universit...
Aberrant activation of TRIP13-EZH2 signaling axis promotes stemness and therapy resistance in multiple myeloma
Aberrant activation of TRIP13-EZH2 signaling axis promotes stemness and therapy resistance in multiple myeloma
Huang T, Song X, Xu D, Tiek D, Goenka A, Wu B, et al. Stem cell programs in cancer initiation, progression, and therapy re...
A novel lncRNA SNHG29 regulates EP300- related histone acetylation modification and inhibits FLT3-ITD AML development
A novel lncRNA SNHG29 regulates EP300- related histone acetylation modification and inhibits FLT3-ITD AML development
Internal tandem duplication (ITD) mutations within the FMS-like tyrosine kinase-3 (FLT3) occur in up to 25% of acute myelo...
Allogeneic hematopoietic stem cell transplantation for NK/T-cell lymphoma: an international collaborative analysis
Allogeneic hematopoietic stem cell transplantation for NK/T-cell lymphoma: an international collaborative analysis
Natural killer/T-cell lymphomas (NKTCL) represent rare and aggressive lymphoid malignancies. Patients (pts) with relapsed/...
Mast cell deficiency prevents BCR::ABL1 induced splenomegaly and cytokine elevation in a CML mouse model
Mast cell deficiency prevents BCR::ABL1 induced splenomegaly and cytokine elevation in a CML mouse model
The persistence of leukemic stem cells (LSCs) represents a problem in the therapy of chronic myeloid leukemia (CML). Hence...
Network analysis reveals a major role for 14q32 cluster miRNAs in determining transcriptional differences between IGHV-mutated and unmutated CLL
Network analysis reveals a major role for 14q32 cluster miRNAs in determining transcriptional differences between IGHV-mutated and unmutated CLL
Chronic lymphocytic leukaemia (CLL) cells can express unmutated (U-CLL) or mutated (M-CLL) immunoglobulin heavy chain (IGH...
RUNX1 mutation has no prognostic significance in paediatric AML: a retrospective study of the AML-BFM study group
RUNX1 mutation has no prognostic significance in paediatric AML: a retrospective study of the AML-BFM study group
In acute myeloid leukaemia (AML) RUNX1 mutation is characterised by certain clinicopathological features with poor prognos...
Relationship among three common hematological premalignant conditions
Relationship among three common hematological premalignant conditions
In total, 1630 individuals were screened for MBL and MGUS; 1151 (70.6%) were negative for both, 275 (16.9%) identified to ...
Assessment and validation of the molecular international prognostic scoring system for myelodysplastic syndromes
Assessment and validation of the molecular international prognostic scoring system for myelodysplastic syndromes
The Molecular International Prognostic Scoring System (IPSS-M) is a novel risk stratification model for myelodysplastic sy...
Lactate—a new player in G-CSF-induced mobilization of hematopoietic stem/progenitor cells
Lactate—a new player in G-CSF-induced mobilization of hematopoietic stem/progenitor cells
Adamiak M, Bujko K, Cymer M, Plonka M, Glaser T, Kucia M, et al. Novel evidence that extracellular nucleotides and puriner...
Venetoclax consolidation in high-risk CLL treated with ibrutinib for ≥1 year achieves a high rate of undetectable MRD
Venetoclax consolidation in high-risk CLL treated with ibrutinib for ≥1 year achieves a high rate of undetectable MRD
Patients receiving ibrutinib for CLL rarely achieve undetectable measurable residual disease (U-MRD), necessitating indefi...
Molecular mechanisms underlying transformation of large granular lymphocytic leukemia to high-grade T-cell lymphoma
Molecular mechanisms underlying transformation of large granular lymphocytic leukemia to high-grade T-cell lymphoma
Alaggio R, Amador C, Anagnostopoulos I, Attygalle AD, Araujo IBO, Berti E, et al. The 5th edition of the World Health Orga...
Management of patients with multiple myeloma and COVID-19 in the post pandemic era: a consensus paper from the European Myeloma Network (EMN)
In the post-pandemic COVID-19 period, human activities have returned to normal and COVID-19 cases are usually mild. Howeve...
Characterization of immune exhaustion and suppression in the tumor microenvironment of splenic marginal zone lymphoma
Characterization of immune exhaustion and suppression in the tumor microenvironment of splenic marginal zone lymphoma
The role of the tumor microenvironment (TME) and intratumoral T cells in splenic marginal zone lymphoma (sMZL) is largely ...
Glucose partitioning in the bone marrow micro-environment in acute myeloid leukaemia
Glucose partitioning in the bone marrow micro-environment in acute myeloid leukaemia
Acute myeloid leukaemia (AML) cells metabolise glucose by glycolysis-based re-programming. However, how glucose uptake is ...
Spatial single cell analysis of tumor microenvironment remodeling pattern in primary central nervous system lymphoma
Spatial single cell analysis of tumor microenvironment remodeling pattern in primary central nervous system lymphoma
To determine the overall tumor microenvironment (TME), characteristics, and transition mechanisms in primary central nervo...
AML classification in the year 2023: How to avoid a Babylonian confusion of languages
AML classification in the year 2023: How to avoid a Babylonian confusion of languages
In parallel to the 5th edition of the World Health Organization Classification of Haematolymphoid Tumours (WHO 2022), an a...
What causes aplastic anaemia?
Young NS. Aplastic anemia. N Engl J Med. 2018;379:1643–56. https://doi.org/10.1056/NEJMra1413485.Article  CAS  Pub...
Adapter CAR T cells to counteract T-cell exhaustion and enable flexible targeting in AML
Adapter CAR T cells to counteract T-cell exhaustion and enable flexible targeting in AML
Although the landscape for treating acute myeloid leukemia (AML) patients has changed substantially in recent years, the m...
HIF1α-mediated transactivation of WTAP promotes AML cell proliferation via m6A-dependent stabilization of KDM4B mRNA
HIF1α-mediated transactivation of WTAP promotes AML cell proliferation via m6A-dependent stabilization of KDM4B mRNA
Hypoxia inducible factor 1α (HIF1α) is abnormally overexpressed in t(8;21) acute myeloid leukemia (AML) and func...
Targeting DNA polymerase β elicits synthetic lethality with mismatch repair deficiency in acute lymphoblastic leukemia
Targeting DNA polymerase β elicits synthetic lethality with mismatch repair deficiency in acute lymphoblastic leukemia
Mismatch repair (MMR) deficiency has been linked to thiopurine resistance and hypermutation in relapsed acute lymphoblasti...
Transcription factor Nkx2-3 maintains the self-renewal of hematopoietic stem cells by regulating mitophagy
Transcription factor Nkx2-3 maintains the self-renewal of hematopoietic stem cells by regulating mitophagy
Hematopoietic stem cells (HSCs) reside at the top of the hematopoietic hierarchy, exhibiting a unique capacity to self-ren...
Blocking the CD47-SIRPα interaction reverses the disease phenotype in a polycythemia vera mouse model
Blocking the CD47-SIRPα interaction reverses the disease phenotype in a polycythemia vera mouse model
Polycythemia vera (PV) is a hematopoietic stem cell neoplasm driven by somatic mutations in JAK2, leading to increased red...
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