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Transient regulation of RNA methylation in human hematopoietic stem cells promotes their homing and engraftment
Transient regulation of RNA methylation in human hematopoietic stem cells promotes their homing and engraftment
Enhancing the efficiency of hematopoietic stem cell (HSC) homing and engraftment is critical for cord blood (CB) hematopoi...
Mutations in spliceosome genes in myelodysplastic neoplasms and their association to ring sideroblasts
Mutations in spliceosome genes in myelodysplastic neoplasms and their association to ring sideroblasts
Two new proposals for the classification of myeloid malignancies have been presented: the 5th edition of the WHO Classific...
Analysis and therapeutic targeting of the EP300 and CREBBP acetyltransferases in anaplastic large cell lymphoma and Hodgkin lymphoma
Analysis and therapeutic targeting of the EP300 and CREBBP acetyltransferases in anaplastic large cell lymphoma and Hodgkin lymphoma
Anaplastic large cell lymphoma (ALCL) and classical Hodgkin lymphoma (HL) share a similar cytological and high surface exp...
A comparison of the International Consensus and 5th World Health Organization classifications of mature B-cell lymphomas
A comparison of the International Consensus and 5th World Health Organization classifications of mature B-cell lymphomas
Several editions of the World Health Organization (WHO) classifications of lympho-hemopoietic neoplasms in 2001, 2008 and ...
Retraction Note: Prognostic models for chronic lymphocytic leukemia (CLL): a systematic review and meta-analysis
Authors and AffiliationsDepartment Hematology–Oncology, Azienda Ospedaliera Pugliese-Ciaccio, Catanzaro, ItalyStefano Moli...
Sustained activation of non-canonical NF-κB signalling drives glycolytic reprogramming in doxorubicin-resistant DLBCL
Sustained activation of non-canonical NF-κB signalling drives glycolytic reprogramming in doxorubicin-resistant DLBCL
DLBCL is the most common lymphoma with high tumor heterogeneity. Treatment refractoriness and relapse from R-CHOP therapy ...
The ENL YEATS epigenetic reader domain critically links MLL-ENL to leukemic stem cell frequency in t(11;19) Leukemia
The ENL YEATS epigenetic reader domain critically links MLL-ENL to leukemic stem cell frequency in t(11;19) Leukemia
MLL (KMT2a) translocations are found in ~10% of acute leukemia patients, giving rise to oncogenic MLL-fusion proteins. A c...
Diagnostics in Waldenström’s macroglobulinemia: a consensus statement of the European Consortium for Waldenström’s Macroglobulinemia
The diagnosis of Waldenström’s macroglobulinemia (WM), an IgM-associated lymphoplasmacytic lymphoma, can be cha...
Biological drivers of clinical phenotype in myelofibrosis
Biological drivers of clinical phenotype in myelofibrosis
Myelofibrosis (MF) is a myeloproliferative disorder that exhibits considerable biological and clinical heterogeneity. At t...
Effect of ECOG performance status on outcomes in patients with acute myeloid leukemia and other high-grade myeloid neoplasms
Effect of ECOG performance status on outcomes in patients with acute myeloid leukemia and other high-grade myeloid neoplasms
Patient characteristicsAmong the 1252 patients included, 997 (79.6%) had PS 1; 46 patients (3.7%) had PS 0, and 209 patien...
P2X1 enhances leukemogenesis through PBX3-BCAT1 pathways
P2X1 enhances leukemogenesis through PBX3-BCAT1 pathways
How bone marrow niches regulate leukemogenic activities of leukemia-initiating cells (LICs) is unclear. The present study ...
Isocitrate dehydrogenase 1 mutation drives leukemogenesis by PDGFRA activation due to insulator disruption in acute myeloid leukemia (AML)
Isocitrate dehydrogenase 1 mutation drives leukemogenesis by PDGFRA activation due to insulator disruption in acute myeloid leukemia (AML)
Acute myeloid leukemia (AML) is characterized by complex molecular alterations and driver mutations. Elderly patients show...
Targeting cell cycle and apoptosis to overcome chemotherapy resistance in acute myeloid leukemia
Targeting cell cycle and apoptosis to overcome chemotherapy resistance in acute myeloid leukemia
Chemotherapy-resistant acute myeloid leukemia (AML), frequently driven by clonal evolution, has a dismal prognosis. A geno...
Managing Waldenström’s macroglobulinemia with BTK inhibitors
Managing Waldenström’s macroglobulinemia with BTK inhibitors
Bruton’s tyrosine kinase (BTK) inhibition is one of the treatment standards for patients with relapsed/refractory Wa...
Preclinical efficacy of azacitidine and venetoclax for infant KMT2A-rearranged acute lymphoblastic leukemia reveals a new therapeutic strategy
Preclinical efficacy of azacitidine and venetoclax for infant KMT2A-rearranged acute lymphoblastic leukemia reveals a new therapeutic strategy
Infants with KMT2A-rearranged B-cell acute lymphoblastic leukemia (ALL) have a dismal prognosis. Survival outcomes have re...
Should we give oligomonocytic chronic myelomonocytic leukemia a higher prominence in the next WHO Classification of Haematolymphoid Tumors?
Khoury JD, Solary E, Abla O, Akkari Y, Alaggio R, Apperley JF, et al. The 5th edition of the World Health Organization cla...
VIP152 is a selective CDK9 inhibitor with pre-clinical in vitro and in vivo efficacy in chronic lymphocytic leukemia
VIP152 is a selective CDK9 inhibitor with pre-clinical in vitro and in vivo efficacy in chronic lymphocytic leukemia
Chronic lymphocytic leukemia (CLL) is effectively treated with targeted therapies including Bruton tyrosine kinase inhibit...
Frequency and prognostic implications of KMT2A rearrangements in children with precursor B-cell lymphoma
Frequency and prognostic implications of KMT2A rearrangements in children with precursor B-cell lymphoma
Precursor B-cell lymphoma (BCP-L) and leukemia (BCP-ALL), also known as B-lymphoblastic lymphoma/leukemia, are neoplasms o...
Genetic deletion and pharmacologic inhibition of E3 ubiquitin ligase HOIP impairs the propagation of myeloid leukemia
Genetic deletion and pharmacologic inhibition of E3 ubiquitin ligase HOIP impairs the propagation of myeloid leukemia
We investigated the role of Hoip, a catalytic subunit of linear ubiquitin chain assembly complex (LUBAC), in adult hematop...
mTOR inhibition amplifies the anti-lymphoma effect of PI3Kβ/δ blockage in diffuse large B-cell lymphoma
mTOR inhibition amplifies the anti-lymphoma effect of PI3Kβ/δ blockage in diffuse large B-cell lymphoma
Diffuse large B-cell lymphoma (DLBCL) is an aggressive disease that exhibits constitutive activation of phosphoinositide 3...
Inhibition of USP1 reverses the chemotherapy resistance through destabilization of MAX in the relapsed/refractory B-cell lymphoma
Inhibition of USP1 reverses the chemotherapy resistance through destabilization of MAX in the relapsed/refractory B-cell lymphoma
The patients with relapsed and refractory diffuse large B-cell lymphoma (DLBCL) have poor prognosis, and a novel and effec...
Correction: Translatome proteomics identifies autophagy as a resistance mechanism to on-target FLT3 inhibitors in acute myeloid leukemia
These authors contributed equally: Christian Münch, Christian H. Brandts.Department of Medicine, Hematology/Oncology, Univ...
Discriminating activities of DEAD-Box Helicase 41 from myeloid malignancy-associated germline variants by genetic rescue
Discriminating activities of DEAD-Box Helicase 41 from myeloid malignancy-associated germline variants by genetic rescue
Tawana K, Brown AL, Churpek JE. Integrating germline variant assessment into routine clinical practice for myelodysplastic...
Impact of pre-transplant induction and consolidation cycles on AML allogeneic transplant outcomes: a CIBMTR analysis in 3113 AML patients
Impact of pre-transplant induction and consolidation cycles on AML allogeneic transplant outcomes: a CIBMTR analysis in 3113 AML patients
We investigated the impact of the number of induction/consolidation cycles on outcomes of 3113 adult AML patients who rece...
Identification and interrogation of the gene regulatory network of CEBPA-double mutant acute myeloid leukemia
Identification and interrogation of the gene regulatory network of CEBPA-double mutant acute myeloid leukemia
Acute myeloid leukemia (AML) is a heterogeneous hematological malignancy caused by mutations in genes encoding transcripti...