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Multi-omic analysis of chronic myelomonocytic leukemia monocytes reveals metabolic and immune dysregulation leading to altered macrophage polarization
Multi-omic analysis of chronic myelomonocytic leukemia monocytes reveals metabolic and immune dysregulation leading to altered macrophage polarization
Chronic myelomonocytic leukemia (CMML) is a clonal myelodysplastic/myeloproliferative neoplasm characterized by persistent...
Prognostic impact of expression of CD2, CD25, and/or CD30 in/on mast cells in systemic mastocytosis: a registry study of the European Competence Network on Mastocytosis
Prognostic impact of expression of CD2, CD25, and/or CD30 in/on mast cells in systemic mastocytosis: a registry study of the European Competence Network on Mastocytosis
Expression of CD2, CD25 and/or CD30 in extracutaneous mast cells (MC) is a minor diagnostic criterion for systemic mastocy...
Daratumumab plus lenalidomide/dexamethasone in untreated multiple myeloma: analysis of key subgroups of the MAIA study
Daratumumab plus lenalidomide/dexamethasone in untreated multiple myeloma: analysis of key subgroups of the MAIA study
In the MAIA study (median follow-up, 56.2 months), daratumumab plus lenalidomide and dexamethasone (D-Rd) significantly im...
Prognostic, biological, and structural implications of FLT3-JMD point mutations in acute myeloid leukemia: an analysis of Alliance studies
Prognostic, biological, and structural implications of FLT3-JMD point mutations in acute myeloid leukemia: an analysis of Alliance studies
The FLT3 gene frequently undergoes mutations in acute myeloid leukemia (AML), with internal tandem duplications (ITD) and ...
EZH2 modulates mRNA splicing and exerts part of its oncogenic function through repression of splicing factors in CML
EZH2 modulates mRNA splicing and exerts part of its oncogenic function through repression of splicing factors in CML
The polycomb protein EZH2 is up-regulated in Chronic Myeloid Leukaemia (CML) and associated with transcriptional reprogram...
Modeling GATA2 deficiency in mice: the R396Q mutation disrupts normal hematopoiesis
Modeling GATA2 deficiency in mice: the R396Q mutation disrupts normal hematopoiesis
GATA2 deficiency is an autosomal dominant germline disorder of immune dysfunction and bone marrow failure with a high prop...
A novel prognostic risk model for patients with refractory/relapsed acute myeloid leukemia receiving venetoclax plus hypomethylating agents
A novel prognostic risk model for patients with refractory/relapsed acute myeloid leukemia receiving venetoclax plus hypomethylating agents
Off-label hypomethylating agents and venetoclax (HMA/VEN) are often used for relapsed and refractory (R/R) AML patients. H...
Non canonical c-CBL mutations define a specific phenotype of myeloid neoplasia
Non canonical c-CBL mutations define a specific phenotype of myeloid neoplasia
CBL proteins are a family of RING finger E3 ubiquitin ligases that regulate proliferative signals via ubiquitination and d...
Genetic analysis of myeloid neoplasms with der(1;7)(q10;p10)
Genetic analysis of myeloid neoplasms with der(1;7)(q10;p10)
der(1;7)(q10;p10) is an unbalanced translocation recurrently found in a variety of myeloid neoplasms, where +1q and −7q ar...
HMGA2 overexpression with specific chromosomal abnormalities predominate in CALR and ASXL1 mutated myelofibrosis
HMGA2 overexpression with specific chromosomal abnormalities predominate in CALR and ASXL1 mutated myelofibrosis
Although multiple genetic events are thought to play a role in promoting progression of the myeloproliferative neoplasms (...
PAX5::AUTS2 childhood B-ALL: a relapse-prone genetic subtype with frequent central nervous system involvement and a poor outcome
PAX5::AUTS2 childhood B-ALL: a relapse-prone genetic subtype with frequent central nervous system involvement and a poor outcome
In childhood and young adolescent B-cell precursor acute lymphoblastic leukemia (B-ALL) PAX5 is one of the most frequent t...
ADAR1 is required for acute myeloid leukemia cell survival by modulating post-transcriptional Wnt signaling through impairing miRNA biogenesis
ADAR1 is required for acute myeloid leukemia cell survival by modulating post-transcriptional Wnt signaling through impairing miRNA biogenesis
Recent extensive studies on the genomic and molecular profiles of acute myeloid leukemia (AML) have expanded the treatment...
Genetic susceptibility of diffuse large B-cell lymphoma: a meta genome-wide association study in Asian population
Genetic susceptibility of diffuse large B-cell lymphoma: a meta genome-wide association study in Asian population
Diffuse large B-cell lymphoma (DLBCL) is an aggressive malignancy and the most common form of non-Hodgkin lymphoma (NHL) t...
Capillary leak phenotype as a major cause of death in patients with POEMS syndrome
Capillary leak phenotype as a major cause of death in patients with POEMS syndrome
Cause of death (COD) in POEMS (polyneuropathy, organomegaly, endocrinopathies, monoclonal protein and skin changes) syndro...
Functions of the native NPM1 protein and its leukemic mutant
Functions of the native NPM1 protein and its leukemic mutant
The nucleophosmin (NPM1) gene encodes for the most abundant nucleolar protein. Thanks to its property to act as histone ch...
T-cell diversity and exclusion of blood-derived T-cells in the tumor microenvironment of classical Hodgkin Lymphoma
T-cell diversity and exclusion of blood-derived T-cells in the tumor microenvironment of classical Hodgkin Lymphoma
The Tumor Microenvironment (TME) in classical Hodgkin Lymphoma (HL) contains abundant immune cells and only few neoplastic...
Immunoglobulin light chain mutational status refines IGHV prognostic value in identifying chronic lymphocytic leukemia patients with early treatment requirement
Immunoglobulin light chain mutational status refines IGHV prognostic value in identifying chronic lymphocytic leukemia patients with early treatment requirement
The mutational status of immunoglobulin (IG) light chain genes in chronic lymphocytic leukemia (CLL) and its clinical impa...
Co-targeting of the thymic stromal lymphopoietin receptor to decrease immunotherapeutic resistance in CRLF2-rearranged Ph-like and Down syndrome acute lymphoblastic leukemia
Co-targeting of the thymic stromal lymphopoietin receptor to decrease immunotherapeutic resistance in CRLF2-rearranged Ph-like and Down syndrome acute lymphoblastic leukemia
CRLF2 rearrangements occur in >50% of Ph-like and Down syndrome (DS)-associated B-acute lymphoblastic leukemia (ALL...
Allogeneic hematopoietic stem cell transplantation in adult acute myeloid leukemia with t(16;21)(p11;q22)/FUS::ERG
Allogeneic hematopoietic stem cell transplantation in adult acute myeloid leukemia with t(16;21)(p11;q22)/FUS::ERG
Department of Hematology, Kobe City Medical Center General Hospital, Kobe, JapanSatoshi Mitsuyuki & Yoshimitsu Shimomu...
Prognostic relevance of treatment deviations in children with relapsed acute lymphoblastic leukemia who were treated in the ALL-REZ BFM 2002 study
Prognostic relevance of treatment deviations in children with relapsed acute lymphoblastic leukemia who were treated in the ALL-REZ BFM 2002 study
Relapsed Acute Lymphoblastic Leukemia (ALL) is among the most common causes of cancer-associated deaths in children. Howev...
Growth retardation and adult height in pediatric patients with chronic-phase chronic myeloid leukemia treated with tyrosine kinase inhibitors
Growth retardation and adult height in pediatric patients with chronic-phase chronic myeloid leukemia treated with tyrosine kinase inhibitors
Roy Moulik N, Keerthivasagam S, Pandey A, Agiwale J, Hegde K, Chatterjee G, et al. Treatment and follow-up of children wit...
Acute myeloid leukemia associated RUNX1 variants induce aberrant expression of transcription factor TCF4
Acute myeloid leukemia associated RUNX1 variants induce aberrant expression of transcription factor TCF4
Bullinger L, Dohner K, Dohner H. Genomics of Acute Myeloid Leukemia Diagnosis and Pathways. J Clin Oncol Off J Am Soc Clin...
Relationship between donor source, pre-transplant measurable residual disease, and outcome after allografting for adults with acute myeloid leukemia
Relationship between donor source, pre-transplant measurable residual disease, and outcome after allografting for adults with acute myeloid leukemia
Lack of HLA-matched related/unrelated donor remains a barrier to allogeneic hematopoietic cell transplantation (HCT) for a...
Mpox in people with haematological cancers
Competing interests RPG is a consultant to Antengene Biotech LLC; Medical Direct...
Incidence of Richter transformation of chronic lymphocytic leukemia/small lymphocytic lymphoma in the targeted therapy era
Incidence of Richter transformation of chronic lymphocytic leukemia/small lymphocytic lymphoma in the targeted therapy era
Competing interests The authors declare no competing financial interests in dire...
Surrogate endpoints in mature B-cell neoplasms – meaningful or misleading?
Surrogate endpoints in mature B-cell neoplasms – meaningful or misleading?
Indolent mature B-cell neoplasms are a group of diseases in which recent therapeutic advances have led to an improved over...
Is there really an accelerated phase of chronic myeloid leukaemia at presentation?
Is there really an accelerated phase of chronic myeloid leukaemia at presentation?
Whether there is really a distinct accelerated phase (AP) at diagnosis in chronic myeloid leukaemia (CML) in the context o...
HMX3 is a critical vulnerability in MECOM-negative KMT2A::MLLT3 acute myelomonocytic leukemia
HMX3 is a critical vulnerability in MECOM-negative KMT2A::MLLT3 acute myelomonocytic leukemia
KMT2A::MLLT3 acute myelomonocytic leukemia (AML) comes in two clinically and biologically different subtypes. One is chara...
Correction: Efficacy and safety in a 4-year follow-up of the ELEVATE-TN study comparing acalabrutinib with or without obinutuzumab versus obinutuzumab plus chlorambucil in treatment-naïve chronic lymphocytic leukemia
Willamette Valley Cancer Institute and Research Center, Eugene, OR, USAJeff P. SharmanSomogy County Mór Kaposi General Hos...
Spatial transcriptomic approaches for characterising the bone marrow landscape: pitfalls and potential
Spatial transcriptomic approaches for characterising the bone marrow landscape: pitfalls and potential
Zeira R, Land M, Strzalkowski A, Raphael BJ. Alignment and integration of spatial transcriptomics data. Nat Methods. 2022;...
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