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Hetero-Oligomeric Protein Pores for Single-Molecule Sensing
Hetero-Oligomeric Protein Pores for Single-Molecule Sensing
Protein nanopores are emerging as versatile single-molecule sensors with broad applications in DNA and protein sequencing....
Interaction of an Oomycete Nep1-like Cytolysin with Natural and Plant Cell-Mimicking Membranes
Interaction of an Oomycete Nep1-like Cytolysin with Natural and Plant Cell-Mimicking Membranes
Plants are attacked by various pathogens that secrete a variety of effectors to damage host cells and facilitate infection...
Effect of Triterpenoids Betulin and Betulinic Acid on Pulmonary Surfactant Membranes
Effect of Triterpenoids Betulin and Betulinic Acid on Pulmonary Surfactant Membranes
The purpose of this work is to examine how triterpenoids betulin (BE) and betulinic acid (BA) affect the thermotropic phas...
The Role of the Swollen State in Cell Proliferation
The Role of the Swollen State in Cell Proliferation
Cell swelling is known to be involved in various stages of the growth of plant cells and microorganisms but in mammalian c...
Sphingomyelin Inhibits Hydrolytic Activity of Heterodimeric PLA2 in Model Myelin Membranes: Pharmacological Relevance
Sphingomyelin Inhibits Hydrolytic Activity of Heterodimeric PLA2 in Model Myelin Membranes: Pharmacological Relevance
In this work, the heterodimeric phospholipase A2, HDP-2, from viper venom was investigated for its hydrolytic activity in ...
Postsynaptic Density Proteins and Their Role in the Trafficking of Group I Metabotropic Glutamate Receptors
Postsynaptic Density Proteins and Their Role in the Trafficking of Group I Metabotropic Glutamate Receptors
Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system that regulates multiple differe...
Voltage Gated Ion Channels and Sleep
Voltage Gated Ion Channels and Sleep
Ion channels are integral components of the nervous system, playing a pivotal role in shaping membrane potential, neuronal...
Enhancing Anti-Cancer Immune Response by Acidosis-Sensitive Nanobody Display
Enhancing Anti-Cancer Immune Response by Acidosis-Sensitive Nanobody Display
One of the main challenges with many cancer immunotherapies is that biomarkers are needed for targeting. These biomarkers ...
Early Events in β2AR Dimer Dynamics Mediated by Activation-Related Microswitches
Early Events in β2AR Dimer Dynamics Mediated by Activation-Related Microswitches
G-Protein-Coupled Receptors (GPCRs) make up around 3–4% of the human genome and are the targets of one-third of FDA-...
Evolution of Bioelectric Membrane Potentials: Implications in Cancer Pathogenesis and Therapeutic Strategies
Evolution of Bioelectric Membrane Potentials: Implications in Cancer Pathogenesis and Therapeutic Strategies
Electrophysiology typically deals with the electrical properties of excitable cells like neurons and muscles. However, all...
Residues of TRPM8 at the Lipid-Water-Interface have Coevolved with Cholesterol Interaction and are Relevant for Diverse Health Disorders
Residues of TRPM8 at the Lipid-Water-Interface have Coevolved with Cholesterol Interaction and are Relevant for Diverse Health Disorders
TRPM8 is a non-selective cation channel that is expressed in several tissues and cells and also has a unique property to b...
Feasibility Study for the Use of Gene Electrotransfer and Cell Electrofusion as a Single-Step Technique for the Generation of Activated Cancer Cell Vaccines
Feasibility Study for the Use of Gene Electrotransfer and Cell Electrofusion as a Single-Step Technique for the Generation of Activated Cancer Cell Vaccines
Cell-based therapies hold great potential for cancer immunotherapy. This approach is based on manipulation of dendritic ce...
A Model for Reversible Electroporation to Deliver Drugs into Diseased Tissues
A Model for Reversible Electroporation to Deliver Drugs into Diseased Tissues
Drug delivery through electroporation could be highly beneficial for the treatment of different types of diseased tissues ...
Correlation Between Antimicrobial Structural Classes and Membrane Partitioning: Role of Emerging Lipid Packing Defects
Correlation Between Antimicrobial Structural Classes and Membrane Partitioning: Role of Emerging Lipid Packing Defects
In this study, a combination of bioinformatics and molecular dynamics simulations is employed to investigate the partition...
N-Glycosylation Deficiency in Transgene α7 nAChR and RIC3 Expressing CHO Cells Without NACHO
N-Glycosylation Deficiency in Transgene α7 nAChR and RIC3 Expressing CHO Cells Without NACHO
The human neuronal nicotinic acetylcholine receptor α7 (nAChR) is an important target implicated in diseases like Alz...
Sperm-Specific CatSper is Not Conserved in All Vertebrates and May Not be the Only Progesterone-Responsive Ion Channel Present in Sperm
Sperm-Specific CatSper is Not Conserved in All Vertebrates and May Not be the Only Progesterone-Responsive Ion Channel Present in Sperm
Progesterone (P4) acts as a key conserved signalling molecule in vertebrate reproduction. P4 is especially important for m...
A Critical Review of Short Antimicrobial Peptides from Scorpion Venoms, Their Physicochemical Attributes, and Potential for the Development of New Drugs
A Critical Review of Short Antimicrobial Peptides from Scorpion Venoms, Their Physicochemical Attributes, and Potential for the Development of New Drugs
Scorpion venoms have proven to be excellent sources of antimicrobial agents. However, although many of them have been func...
Aggregation Behavior of Amyloid Beta Peptide Depends Upon the Membrane Lipid Composition
Aggregation Behavior of Amyloid Beta Peptide Depends Upon the Membrane Lipid Composition
Protein aggregation plays a crucial role in the development of several neurodegenerative diseases. It is important to unde...
Abundance of the Membrane Proteome in Yeast Cells Lacking Spc1, a Non-catalytic Subunit of the Signal Peptidase Complex
Abundance of the Membrane Proteome in Yeast Cells Lacking Spc1, a Non-catalytic Subunit of the Signal Peptidase Complex
The signal peptidase complex (SPC) mediates processing of signal peptides of secretory precursors. But, recent studies sho...
Beyond Hormones: Investigating the Impact of Progesterone Receptor Membrane Component 1 in Lung Adenocarcinoma
Beyond Hormones: Investigating the Impact of Progesterone Receptor Membrane Component 1 in Lung Adenocarcinoma
Progesterone Receptor Membrane Component 1 (PGRMC1) is a candidate oncogene with a prominent involvement in the pathogenes...
Quantal Properties of Voltage-Dependent Ca2+ Release in Frog Skeletal Muscle Persist After Reduction of [Ca2+] in the Sarcoplasmic Reticulum
Quantal Properties of Voltage-Dependent Ca2+ Release in Frog Skeletal Muscle Persist After Reduction of [Ca2+] in the Sarcoplasmic Reticulum
In skeletal muscle, the Ca2+ release flux elicited by a voltage clamp pulse rises to an early peak that inactivates rapidl...
Construction and Analysis of a Mitochondrial Metabolism-Related Prognostic Model for Breast Cancer to Evaluate Survival and Immunotherapy
Construction and Analysis of a Mitochondrial Metabolism-Related Prognostic Model for Breast Cancer to Evaluate Survival and Immunotherapy
As one of the most prevalent malignancies among women, breast cancer (BC) is tightly linked to metabolic dysfunction. Howe...
Bioinformatic Study of Possible Acute Regulation of Acid Secretion in the Stomach
Bioinformatic Study of Possible Acute Regulation of Acid Secretion in the Stomach
The gastric H+,K+-ATPase is an integral membrane protein which derives energy from the hydrolysis of ATP to transport H+ i...
Potential Role of Nrf2, HER2, and ALDH in Cancer Stem Cells: A Narrative Review
Potential Role of Nrf2, HER2, and ALDH in Cancer Stem Cells: A Narrative Review
Cancer is one of the main causes of death among humans, second only to cardiovascular diseases. In recent years, numerous ...
Study of the Membrane Activity of the Synthetic Peptide ∆M3 Against Extended-Spectrum β-lactamase Escherichia coli Isolates
Study of the Membrane Activity of the Synthetic Peptide ∆M3 Against Extended-Spectrum β-lactamase Escherichia coli Isolates
Escherichia coli is the most common microorganism causing nosocomial or community-acquired bacteremia, and extended-spectr...
Streamlined Biotinylation, Enrichment and Analysis for Enhanced Plasma Membrane Protein Identification Using TurboID and TurboID-Start Biotin Ligases
Streamlined Biotinylation, Enrichment and Analysis for Enhanced Plasma Membrane Protein Identification Using TurboID and TurboID-Start Biotin Ligases
Plasma membrane proteins (PMPs) play pivotal roles in various cellular events and are crucial in disease pathogenesis, mak...
Isolated Cardiac Ryanodine Receptor Function Varies Between Mammals
Isolated Cardiac Ryanodine Receptor Function Varies Between Mammals
Concerted robust opening of cardiac ryanodine receptors’ (RyR2) Ca2+ release 1oplasmic reticulum (SR) is fundamental...
Schisandrin B Alleviates LPS Induced Mitochondrial Damage in C28I2 Cells
Schisandrin B Alleviates LPS Induced Mitochondrial Damage in C28I2 Cells
Osteoarthritis is a common joint disease characterized by damage to the joint cartilage that occurs throughout the entire ...
Correction: Role of Hydrophobic Amino-Acid Side-Chains in the Narrow Selectivity Filter of the CFTR Chloride Channel Pore in Conductance and Selectivity
Correction: Role of Hydrophobic Amino-Acid Side-Chains in the Narrow Selectivity Filter of the CFTR Chloride Channel Pore in Conductance and Selectivity
Relationships between amino-acid side-chain volume at position 337, single channel conductance, and SCN– permeability. a C...
Effects of Chemical Fixatives on Kinetic Measurements of Biomolecular Interaction on Cell Membrane
Effects of Chemical Fixatives on Kinetic Measurements of Biomolecular Interaction on Cell Membrane
Understanding the interaction between ligands and membrane proteins is important for drug design and optimization. Althoug...
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