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CN1699 Our Business - Guide for Agents
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Correction to: Screening for ferroptosis genes related to endometrial carcinoma and predicting of targeted drugs based on bioinformatics
Diagnostic and prognostic ROC curves based on the validated obtained hub genes. A–C Diagnostic ROC curves for CDKN2A, NRAS...
Archives Of Toxicology
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Identification of phase-I and phase-II metabolites and the metabolic pathway of the novel synthetic cannabinoid 5F-EDMB-PICA in vitro
5F-EDMB-PICA is a newly emerged synthetic cannabinoid which has been characterized in relevant literature in recent years....
Archives Of Toxicology
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In vitro screening of understudied PFAS with a focus on lipid metabolism disruption
Per- and polyfluoroalkyl substances (PFAS) are man-made chemicals used in many industrial applications. Exposure to PFAS i...
Archives Of Toxicology
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Does a postmortem redistribution affect the concentrations of the 7 azaindole-derived synthetic cannabinoid 5F-MDMB-P7AICA in tissues and body fluids following pulmonary administration to pigs?
Many fatal intoxications have been reported in connection with the consumption of newer, highly potent synthetic cannabino...
Archives Of Toxicology
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Atorvastatin exerts a preventive effect against steroid-induced necrosis of the femoral head by modulating Wnt5a release
Steroid-induced osteonecrosis of the femoral head (SONFH) is a prevalent form of osteonecrosis in young individuals. More ...
Archives Of Toxicology
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Targeting ferroptosis by natural products in pathophysiological conditions
Ferroptosis is a form of cell death that is induced by iron-mediated accumulation of lipid peroxidation. The involvement o...
Archives Of Toxicology
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A genetic variant in the TAPBP gene enhances cervical cancer susceptibility by increasing m6A modification
Genetic variants can affect gene expression by altering the level of N6-methyladenosine (m6A) modifications. A better unde...
Archives Of Toxicology
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A multi-biomarker micronucleus assay using imaging flow cytometry
Genetic toxicity testing assesses the potential of compounds to cause DNA damage. There are many genetic toxicology screen...
Archives Of Toxicology
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Synthesis and in vitro assessment of the reactivation profile of clinically available oximes on the acetylcholinesterase model inhibited by A-230 nerve agent surrogate
The risk of the use of toxic chemicals for unlawful acts has been a matter of concern for different governments and multil...
Archives Of Toxicology
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Comparison of DNA damage in fresh and frozen blood samples: implications for the comet assay in human biomonitoring studies
The use of the comet assay in large biomonitoring studies may present logistical and technical challenges because of the p...
Archives Of Toxicology
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A new 3D model of L929 fibroblasts microtissues uncovers the effects of Bothrops erythromelas venom and its antivenom
In Brazil, around 80% of snakebites are caused by snakes of the genus Bothrops. A three-dimensional culture model was stan...
Archives Of Toxicology
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Sirtuin 3-activated superoxide dismutase 2 mediates fluoride-induced osteoblastic differentiation in vitro and in vivo by down-regulating reactive oxygen species
Skeletal fluorosis is a chronic metabolic bone disease caused by long-term excessive fluoride intake. Abnormal differentia...
Archives Of Toxicology
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Integrated systematic functional screen and fine-mapping decipher the role and genetic regulation of RPS19 in colorectal cancer development
Despite genome-wide association studies (GWAS) have identified more than 200 risk loci associated with colorectal cancer (...
Archives Of Toxicology
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The relative nature of the standards for proof of safety: a review of FDA’s safety standards for various consumer products
Are all food ingredients, dietary supplement ingredients and even foods, required to meet the same safety standards? Are t...
Archives Of Toxicology
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Identification of reversible OATP1B1 and time-dependent CYP3A4 inhibition as the major risk factors for drug-induced cholestasis (DIC)
Hepatic bile acid regulation is a multifaceted process modulated by several hepatic transporters and enzymes. Drug-induced...
Archives Of Toxicology
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Differences in endocrine and reproductive responses to substance exposure across generations: highlighting the importance of complementary findings
This article analyzes the results from 112 Extended One-Generation Reproductive Toxicity studies. The objective was to det...
Archives Of Toxicology
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Human metabolism of four synthetic benzimidazole opioids: isotonitazene, metonitazene, etodesnitazene, and metodesnitazene
Following isotonitazene scheduling in 2019, the availability of alternative 2-benzylbenzimidazole opioids (nitazenes) on t...
Archives Of Toxicology
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The evaluation of skin sensitization potential of the UVCB substance diisopentyl phthalate by in silico and in vitro methods
Diisopentyl phthalate (DiPeP) is primarily used as a plasticizer or additive within the production of polyvinyl chloride (...
Archives Of Toxicology
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The role of genetic polymorphisms for inducing genotoxicity in workers occupationally exposed to benzene: a systematic review
Benzene is used worldwide as a major raw material in a number of industrial processes and also a potent airborne pollutant...
Archives Of Toxicology
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Dissecting the networks underlying diverse brain disorders after prenatal glucocorticoid overexposure
New human life begins in the uterus in a period of both extreme plasticity and sensitivity to environmental disturbances. ...
Archives Of Toxicology
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The rat acute oral toxicity of trifluoromethyl compounds (TFMs): a computational toxicology study combining the 2D-QSTR, read-across and consensus modeling methods
All areas of the modern society are affected by fluorine chemistry. In particular, fluorine plays an important role in med...
Archives Of Toxicology
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Repeated-dose toxicity and toxicokinetic study of isobutylparaben in rats subcutaneously treated for 13 weeks
Parabens have historically served as antimicrobial preservatives in a range of consumables such as food, beverages, medica...
Archives Of Toxicology
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Ochratoxin A induces hepatic and renal toxicity in mice through increased oxidative stress, mitochondrial damage, and multiple cell death mechanisms
Ochratoxin A (OTA) is a widespread food toxin produced by Aspergillus ochraceus and other molds. In this study, we develop...
Archives Of Toxicology
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Genotoxicity and safety pharmacology of the rVSVInd(GML)-mspSGtc vaccine against SARS-CoV-2 in Sprague–Dawley rats and Beagle dogs
The emergence of coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led...
Archives Of Toxicology
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AKR1C2 genetic variants mediate tobacco carcinogens metabolism involving bladder cancer susceptibility
Tobacco carcinogens metabolism-related genes (TCMGs) could generate reactive metabolites of tobacco carcinogens, which sub...
Archives Of Toxicology
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Vascular endothelial dysfunction induced by 3-bromofluoranthene via MAPK-mediated-NFκB pro-inflammatory pathway and intracellular ROS generation
3-Bromofluoranthene (3-BrFlu) is the secondary metabolite of fluoranthene, which is classified as a polycyclic aromatic hy...
Archives Of Toxicology
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Integration of apaQTL and eQTL analysis reveals novel SNPs associated with occupational pulmonary fibrosis risk
To explore the association between apaQTL/eQTL-SNPs and the susceptibility to silicosis. A silicosis-related GWAS was init...
Archives Of Toxicology
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Sub-acute oral exposure to lowest observed adverse effect level of nivalenol exacerbates atopic dermatitis in mice via direct activation of mitogen-activated protein kinase signal in antigen-presenting cells
This study investigated the immunotoxic effects of the mycotoxin nivalenol (NIV) using antigen-presenting cells and a mous...
Archives Of Toxicology
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Interaction of the chemotherapeutic agent oxaliplatin and the tyrosine kinase inhibitor dasatinib with the organic cation transporter 2
Oxaliplatin (OHP) is effective in colorectal cancer treatment but induces peripheral neurotoxicity (OHP-induced peripheral...
Archives Of Toxicology
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In vitro to in vivo extrapolation to derive a metabolism factor for estimating the aggregate exposure to salicylic acid after dermal exposure of its esters
As part of the safety assessment of salicylate esters in cosmetics, we developed a metabolism factor based on in vitro to ...
Archives Of Toxicology
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