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In vitro assessment of thyroid peroxidase inhibition by chemical exposure: comparison of cell models and detection methods
In vitro assessment of thyroid peroxidase inhibition by chemical exposure: comparison of cell models and detection methods
Disruption of the thyroid hormone (TH) system is connected with diverse adverse health outcomes in wildlife and humans. It...
Applications of 3D organoids in toxicological studies: a comprehensive analysis based on bibliometrics and advances in toxicological mechanisms
Applications of 3D organoids in toxicological studies: a comprehensive analysis based on bibliometrics and advances in toxicological mechanisms
A mechanism exploration is an important part of toxicological studies. However, traditional cell and animal models can no ...
Mechanistic screening of reproductive toxicity in a novel 3D testicular co-culture model shows significant impairments following exposure to low-dibutyl phthalate concentrations
Mechanistic screening of reproductive toxicity in a novel 3D testicular co-culture model shows significant impairments following exposure to low-dibutyl phthalate concentrations
To improve the mechanistic screening of reproductive toxicants in  chemical-risk assessment and drug development,...
Bisphenol A and its analogues: from their occurrence in foodstuffs marketed in Europe to improved monitoring strategies—a review of published literature from 2018 to 2023
Bisphenol A and its analogues: from their occurrence in foodstuffs marketed in Europe to improved monitoring strategies—a review of published literature from 2018 to 2023
In this review article, the research works covering the analytical determination of bisphenol A (BPA) and its structural a...
First report of X-ray induced somatic mutation by Muller’s department chair fails to support Muller’s linearity hypothesis
First report of X-ray induced somatic mutation by Muller’s department chair fails to support Muller’s linearity hypothesis
This paper reevaluates the first report of X-ray-induced somatic gene mutations. It was undertaken by John Patterson, Depa...
Harnessing machine learning to predict cytochrome P450 inhibition through molecular properties
Harnessing machine learning to predict cytochrome P450 inhibition through molecular properties
Cytochrome P450 enzymes are a superfamily of enzymes responsible for the metabolism of a variety of medicines and xenobiot...
Correction to: Screening for ferroptosis genes related to endometrial carcinoma and predicting of targeted drugs based on bioinformatics
Correction to: Screening for ferroptosis genes related to endometrial carcinoma and predicting of targeted drugs based on bioinformatics
Diagnostic and prognostic ROC curves based on the validated obtained hub genes. A–C Diagnostic ROC curves for CDKN2A, NRAS...
Identification of phase-I and phase-II metabolites and the metabolic pathway of the novel synthetic cannabinoid 5F-EDMB-PICA in vitro
Identification of phase-I and phase-II metabolites and the metabolic pathway of the novel synthetic cannabinoid 5F-EDMB-PICA in vitro
5F-EDMB-PICA is a newly emerged synthetic cannabinoid which has been characterized in relevant literature in recent years....
In vitro screening of understudied PFAS with a focus on lipid metabolism disruption
In vitro screening of understudied PFAS with a focus on lipid metabolism disruption
Per- and polyfluoroalkyl substances (PFAS) are man-made chemicals used in many industrial applications. Exposure to PFAS i...
Does a postmortem redistribution affect the concentrations of the 7 azaindole-derived synthetic cannabinoid 5F-MDMB-P7AICA in tissues and body fluids following pulmonary administration to pigs?
Does a postmortem redistribution affect the concentrations of the 7 azaindole-derived synthetic cannabinoid 5F-MDMB-P7AICA in tissues and body fluids following pulmonary administration to pigs?
Many fatal intoxications have been reported in connection with the consumption of newer, highly potent synthetic cannabino...
Atorvastatin exerts a preventive effect against steroid-induced necrosis of the femoral head by modulating Wnt5a release
Atorvastatin exerts a preventive effect against steroid-induced necrosis of the femoral head by modulating Wnt5a release
Steroid-induced osteonecrosis of the femoral head (SONFH) is a prevalent form of osteonecrosis in young individuals. More ...
Targeting ferroptosis by natural products in pathophysiological conditions
Targeting ferroptosis by natural products in pathophysiological conditions
Ferroptosis is a form of cell death that is induced by iron-mediated accumulation of lipid peroxidation. The involvement o...
A genetic variant in the TAPBP gene enhances cervical cancer susceptibility by increasing m6A modification
A genetic variant in the TAPBP gene enhances cervical cancer susceptibility by increasing m6A modification
Genetic variants can affect gene expression by altering the level of N6-methyladenosine (m6A) modifications. A better unde...
A multi-biomarker micronucleus assay using imaging flow cytometry
A multi-biomarker micronucleus assay using imaging flow cytometry
Genetic toxicity testing assesses the potential of compounds to cause DNA damage. There are many genetic toxicology screen...
Synthesis and in vitro assessment of the reactivation profile of clinically available oximes on the acetylcholinesterase model inhibited by A-230 nerve agent surrogate
Synthesis and in vitro assessment of the reactivation profile of clinically available oximes on the acetylcholinesterase model inhibited by A-230 nerve agent surrogate
The risk of the use of toxic chemicals for unlawful acts has been a matter of concern for different governments and multil...
Comparison of DNA damage in fresh and frozen blood samples: implications for the comet assay in human biomonitoring studies
Comparison of DNA damage in fresh and frozen blood samples: implications for the comet assay in human biomonitoring studies
The use of the comet assay in large biomonitoring studies may present logistical and technical challenges because of the p...
A new 3D model of L929 fibroblasts microtissues uncovers the effects of Bothrops erythromelas venom and its antivenom
A new 3D model of L929 fibroblasts microtissues uncovers the effects of Bothrops erythromelas venom and its antivenom
In Brazil, around 80% of snakebites are caused by snakes of the genus Bothrops. A three-dimensional culture model was stan...
Sirtuin 3-activated superoxide dismutase 2 mediates fluoride-induced osteoblastic differentiation in vitro and in vivo by down-regulating reactive oxygen species
Sirtuin 3-activated superoxide dismutase 2 mediates fluoride-induced osteoblastic differentiation in vitro and in vivo by down-regulating reactive oxygen species
Skeletal fluorosis is a chronic metabolic bone disease caused by long-term excessive fluoride intake. Abnormal differentia...
Integrated systematic functional screen and fine-mapping decipher the role and genetic regulation of RPS19 in colorectal cancer development
Integrated systematic functional screen and fine-mapping decipher the role and genetic regulation of RPS19 in colorectal cancer development
Despite genome-wide association studies (GWAS) have identified more than 200 risk loci associated with colorectal cancer (...
The relative nature of the standards for proof of safety: a review of FDA’s safety standards for various consumer products
The relative nature of the standards for proof of safety: a review of FDA’s safety standards for various consumer products
Are all food ingredients, dietary supplement ingredients and even foods, required to meet the same safety standards? Are t...
Identification of reversible OATP1B1 and time-dependent CYP3A4 inhibition as the major risk factors for drug-induced cholestasis (DIC)
Identification of reversible OATP1B1 and time-dependent CYP3A4 inhibition as the major risk factors for drug-induced cholestasis (DIC)
Hepatic bile acid regulation is a multifaceted process modulated by several hepatic transporters and enzymes. Drug-induced...
Differences in endocrine and reproductive responses to substance exposure across generations: highlighting the importance of complementary findings
Differences in endocrine and reproductive responses to substance exposure across generations: highlighting the importance of complementary findings
This article analyzes the results from 112 Extended One-Generation Reproductive Toxicity studies. The objective was to det...
Human metabolism of four synthetic benzimidazole opioids: isotonitazene, metonitazene, etodesnitazene, and metodesnitazene
Human metabolism of four synthetic benzimidazole opioids: isotonitazene, metonitazene, etodesnitazene, and metodesnitazene
Following isotonitazene scheduling in 2019, the availability of alternative 2-benzylbenzimidazole opioids (nitazenes) on t...
The evaluation of skin sensitization potential of the UVCB substance diisopentyl phthalate by in silico and in vitro methods
The evaluation of skin sensitization potential of the UVCB substance diisopentyl phthalate by in silico and in vitro methods
Diisopentyl phthalate (DiPeP) is primarily used as a plasticizer or additive within the production of polyvinyl chloride (...
The role of genetic polymorphisms for inducing genotoxicity in workers occupationally exposed to benzene: a systematic review
The role of genetic polymorphisms for inducing genotoxicity in workers occupationally exposed to benzene: a systematic review
Benzene is used worldwide as a major raw material in a number of industrial processes and also a potent airborne pollutant...
Dissecting the networks underlying diverse brain disorders after prenatal glucocorticoid overexposure
Dissecting the networks underlying diverse brain disorders after prenatal glucocorticoid overexposure
New human life begins in the uterus in a period of both extreme plasticity and sensitivity to environmental disturbances. ...
The rat acute oral toxicity of trifluoromethyl compounds (TFMs): a computational toxicology study combining the 2D-QSTR, read-across and consensus modeling methods
The rat acute oral toxicity of trifluoromethyl compounds (TFMs): a computational toxicology study combining the 2D-QSTR, read-across and consensus modeling methods
All areas of the modern society are affected by fluorine chemistry. In particular, fluorine plays an important role in med...
Repeated-dose toxicity and toxicokinetic study of isobutylparaben in rats subcutaneously treated for 13 weeks
Repeated-dose toxicity and toxicokinetic study of isobutylparaben in rats subcutaneously treated for 13 weeks
Parabens have historically served as antimicrobial preservatives in a range of consumables such as food, beverages, medica...
Ochratoxin A induces hepatic and renal toxicity in mice through increased oxidative stress, mitochondrial damage, and multiple cell death mechanisms
Ochratoxin A induces hepatic and renal toxicity in mice through increased oxidative stress, mitochondrial damage, and multiple cell death mechanisms
Ochratoxin A (OTA) is a widespread food toxin produced by Aspergillus ochraceus and other molds. In this study, we develop...
Genotoxicity and safety pharmacology of the rVSVInd(GML)-mspSGtc vaccine against SARS-CoV-2 in Sprague–Dawley rats and Beagle dogs
Genotoxicity and safety pharmacology of the rVSVInd(GML)-mspSGtc vaccine against SARS-CoV-2 in Sprague–Dawley rats and Beagle dogs
The emergence of coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led...
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