SCI时时刷

search
+
BMP6 participates in the molecular mechanisms involved in APAP hepatotoxicity
BMP6 participates in the molecular mechanisms involved in APAP hepatotoxicity
Given the lack of accurate diagnostic methods of acetaminophen (APAP)-induced acute liver failure (ALF), the search for ne...
Establishment of a human 3D in vitro liver-bone model as a potential system for drug toxicity screening
Establishment of a human 3D in vitro liver-bone model as a potential system for drug toxicity screening
Drug toxicity is an important cause of chronic liver damage, which in the long term can lead to impaired bone homeostasis ...
Exploring the potential of MRM-IDA-EPI method in mass spectrometry for exposomic analysis: a commentary
Exploring the potential of MRM-IDA-EPI method in mass spectrometry for exposomic analysis: a commentary
Exposomics is a field that studies environmental exposures and their impact on human health. The MRM-IDA-EPI method, which...
Toxicological problems of tattoo removal: characterization of femtosecond laser-induced fragments of Pigment Green 7 and Green Concentrate tattoo ink
Toxicological problems of tattoo removal: characterization of femtosecond laser-induced fragments of Pigment Green 7 and Green Concentrate tattoo ink
Femtosecond lasers represent a novel tool for tattoo removal as sources that can be operated at high power, potentially le...
Insight into the structure, oligomerization, and the role in drug resistance of human UDP-glucuronosyltransferases
Insight into the structure, oligomerization, and the role in drug resistance of human UDP-glucuronosyltransferases
Human UDP-glucuronosyltransferases (UGTs) are pivotal phase II metabolic enzymes facilitating the transfer of glucuronic a...
Re-thinking the link between exposure to mercury and blood pressure
Re-thinking the link between exposure to mercury and blood pressure
Hypertension or high blood pressure (BP) is a prevalent and manageable chronic condition which is a significant c...
Accumulation of chlorinated paraffins in adipocytes is determined by cellular lipid content and chlorination level
Accumulation of chlorinated paraffins in adipocytes is determined by cellular lipid content and chlorination level
Chlorinated paraffins (CPs) are environmental pollutants extensively used in industries. While the use of short-chain chlo...
Kinetically-derived maximal dose (KMD) confirms lack of human relevance for high-dose effects of octamethylcyclotetrasiloxane (D4)
Kinetically-derived maximal dose (KMD) confirms lack of human relevance for high-dose effects of octamethylcyclotetrasiloxane (D4)
The kinetically-derived maximal dose (KMD) is defined as the maximum external dose at which kinetics are unchanged relativ...
Serum levels of thyroxine, thyroid-stimulating hormone, and anti-thyroid peroxidase antibodies and their association with anxiety in environmentally exposed populations in Kazakhstan
Serum levels of thyroxine, thyroid-stimulating hormone, and anti-thyroid peroxidase antibodies and their association with anxiety in environmentally exposed populations in Kazakhstan
Little is known about the impact of environmental pollution on thyroid function in the non-occupationally exposed populati...
Non-invasive in vitro NAM for the detection of reversible and irreversible eye damage after chemical exposure for GHS classification purposes (ImAi)
Non-invasive in vitro NAM for the detection of reversible and irreversible eye damage after chemical exposure for GHS classification purposes (ImAi)
The potential risk of chemicals to the human eye is assessed by adopted test guidelines (TGs) for regulatory purposes to e...
E-cigarettes increase the risk of adenoma formation in murine colorectal cancer model
E-cigarettes increase the risk of adenoma formation in murine colorectal cancer model
E-cigarettes (E.cigs) cause inflammation and damage to human organs, including the lungs and heart. In the gut, E.cig vapi...
Dynamics in zebrafish development define transcriptomic specificity after angiogenesis inhibitor exposure
Dynamics in zebrafish development define transcriptomic specificity after angiogenesis inhibitor exposure
Testing for developmental toxicity is an integral part of chemical regulations. The applied tests are laborious a...
Grouping of chemicals for safety assessment: the importance of toxicokinetic properties of salicylate esters
Grouping of chemicals for safety assessment: the importance of toxicokinetic properties of salicylate esters
Grouping of chemicals has been proposed as a strategy to speed up the screening and identification of potential substances...
Metabolomics and proteomics: synergistic tools for understanding snake venom inhibition
Metabolomics and proteomics: synergistic tools for understanding snake venom inhibition
Snake envenomation presents a significant global health challenge, especially in rural areas of tropical and subtropical r...
In vitro metabolism of seven arolyl-derived fentanyl-type new psychoactive substances
In vitro metabolism of seven arolyl-derived fentanyl-type new psychoactive substances
Over the past decade, fentanyl-type new psychoactive substances (F-NPS) have emerged as the most representative synthetic ...
Critical comparison of BMD and TD50 methods for the calculation of acceptable intakes for N-nitroso compounds
Critical comparison of BMD and TD50 methods for the calculation of acceptable intakes for N-nitroso compounds
The tumorigenic dose 50 (TD50) is a widely used measure of carcinogenic potency which has historically been used to determ...
Elucidating the Phase I metabolism of psilocin in vitro
Elucidating the Phase I metabolism of psilocin in vitro
Psilocin is a well-studied controlled substance with potential psychotherapeutic applications. However, research gaps rema...
Pulmonary exposure to renewable diesel exhaust particles alters protein expression and toxicity profiles in bronchoalveolar lavage fluid and plasma of mice
Pulmonary exposure to renewable diesel exhaust particles alters protein expression and toxicity profiles in bronchoalveolar lavage fluid and plasma of mice
Exposure to diesel exhaust is associated with increased risk of cardiovascular and lung disease. Substituting petroleum di...
Application of physiologically based (PBK) modeling to quantify the effect of the antibiotic tobramycin on bile acid levels in human plasma
Application of physiologically based (PBK) modeling to quantify the effect of the antibiotic tobramycin on bile acid levels in human plasma
Systemic bile acid homeostasis plays an important role in human health. In this study, a physiologically based kinetic (PB...
Drug protection against radiation-induced neurological injury: mechanisms and developments
Drug protection against radiation-induced neurological injury: mechanisms and developments
In daily life, individuals are frequently exposed to various forms of radiation, which, when adhering to safety standards,...
Mitigation of depleted uranium-induced mitochondrial damage by ethylmalonic encephalopathy 1 protein via modulation of hydrogen sulfide and glutathione pathways
Mitigation of depleted uranium-induced mitochondrial damage by ethylmalonic encephalopathy 1 protein via modulation of hydrogen sulfide and glutathione pathways
Depleted uranium (DU) is a byproduct of uranium enrichment, which can cause heavy-metal toxicity and radiation toxicity as...
Hepatoprotective effects of phytochemicals and plant extracts against chemotherapy-induced liver damage in animal models: a systematic review
Hepatoprotective effects of phytochemicals and plant extracts against chemotherapy-induced liver damage in animal models: a systematic review
Chemotherapy, a cornerstone of cancer treatment, is frequently marred by its hepatotoxic effects, which can significantly ...
Molecular mechanisms behind the inhibitory effects of ginsenoside Rg3 on hepatic fibrosis: a review
Molecular mechanisms behind the inhibitory effects of ginsenoside Rg3 on hepatic fibrosis: a review
Hepatitis is a chronic inflammatory liver disease and an important cause of liver fibrosis, which can progress to cirrhosi...
Accelerating antiviral drug discovery: early hazard detection with a dual zebrafish and cell culture screen of a 403 compound library
Accelerating antiviral drug discovery: early hazard detection with a dual zebrafish and cell culture screen of a 403 compound library
The constant emergence of new viral pathogens underscores the need for continually evolving, effective antiviral drugs. A ...
Dermal penetration of 2-phenoxyethanol in humans: in vivo metabolism and toxicokinetics
Dermal penetration of 2-phenoxyethanol in humans: in vivo metabolism and toxicokinetics
2-Phenoxyethanol (PhE) is an amphiphilic organic compound frequently used as a broad-spectrum preservative in cosmetic pro...
Evaluation of the cyto- and genotoxicity of two types of cellulose nanomaterials using human intestinal cells and in vitro digestion simulation
Evaluation of the cyto- and genotoxicity of two types of cellulose nanomaterials using human intestinal cells and in vitro digestion simulation
Emerging cellulose nanomaterials (CNMs) may have commercial impacts in multiple sectors, being their application particula...
Involvement of gut microbiota in chlorpyrifos-induced subchronic toxicity in mice
Involvement of gut microbiota in chlorpyrifos-induced subchronic toxicity in mice
Chlorpyrifos (CPF) is one of the most widely used organophosphorus pesticides all over the world. Unfortunately, long-term...
Impact of Hedgehog modulators on signaling pathways in primary murine and human hepatocytes in vitro: insights into liver metabolism
Impact of Hedgehog modulators on signaling pathways in primary murine and human hepatocytes in vitro: insights into liver metabolism
The Hedgehog (Hh) signaling pathway is essential for maintaining homeostasis during embryogenesis and in adult tissues. In...
The fungicide propiconazole induces hepatic steatosis and activates PXR in a mouse model of diet-induced obesity
The fungicide propiconazole induces hepatic steatosis and activates PXR in a mouse model of diet-induced obesity
Propiconazole is a triazole fungicide previously shown to induce triglyceride accumulation in human liver HepaRG cells, po...
A new human autologous hepatocyte/macrophage co-culture system that mimics drug-induced liver injury–like inflammation
A new human autologous hepatocyte/macrophage co-culture system that mimics drug-induced liver injury–like inflammation
The development of in vitro hepatocyte cell culture systems is crucial for investigating drug-induced liver injury (DILI)....
阅读更多
format_indent_increase