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Toxicity of particles derived from combustion of Ethiopian traditional biomass fuels in human bronchial and macrophage-like cells
Toxicity of particles derived from combustion of Ethiopian traditional biomass fuels in human bronchial and macrophage-like cells
The combustion of traditional fuels in low-income countries, including those in sub-Saharan Africa, leads to extensive ind...
Effect of cell treatment procedures on in vitro genotoxicity assessment
Effect of cell treatment procedures on in vitro genotoxicity assessment
So far, the majority of in vitro toxicological experiments are conducted after an acute 24 h treatment that does ...
Investigating the applicability domain of the hiPSC-based PluriLum assay: an embryotoxicity assessment of chemicals and drugs
Investigating the applicability domain of the hiPSC-based PluriLum assay: an embryotoxicity assessment of chemicals and drugs
To meet the growing demand for developmental toxicity assessment of chemicals, New Approach Methodologies (NAMs) are neede...
Distinct concentration-dependent oxidative stress profiles by cadmium in a rat kidney proximal tubule cell line
Distinct concentration-dependent oxidative stress profiles by cadmium in a rat kidney proximal tubule cell line
Levels and chemical species of reactive oxygen/nitrogen species (ROS/RNS) determine oxidative eustress and distress. Abund...
Molecular signatures of angiogenesis inhibitors: a single-embryo untargeted metabolomics approach in zebrafish
Molecular signatures of angiogenesis inhibitors: a single-embryo untargeted metabolomics approach in zebrafish
Angiogenesis is a key process in embryonic development, a disruption of this process can lead to severe developmental defe...
Ferroptosis regulation through Nrf2 and implications for neurodegenerative diseases
Ferroptosis regulation through Nrf2 and implications for neurodegenerative diseases
This article provides an overview of the background knowledge of ferroptosis in the nervous system, as well as the key rol...
Utility of in vivo metabolomics to support read-across for UVCB substances under REACH
Utility of in vivo metabolomics to support read-across for UVCB substances under REACH
Structure-based grouping of chemicals for targeted testing and read-across is an efficient way to reduce resources and ani...
Sex differences in the tumor promoting effects of tobacco smoke in a cRaf transgenic lung cancer disease model
Sex differences in the tumor promoting effects of tobacco smoke in a cRaf transgenic lung cancer disease model
Tobacco smoke (TS) is the leading cause for lung cancer (LC), and female smokers are at a greater risk for LC. Yet, the un...
The cytotoxicity of microcystin-LR: ultrastructural and functional damage of cells
The cytotoxicity of microcystin-LR: ultrastructural and functional damage of cells
Microcystin-LR (MC-LR) is a toxin produced by cyanobacteria, which is widely distributed in eutrophic water bodies and has...
Artificial intelligence (AI)—it’s the end of the tox as we know it (and I feel fine)*
Artificial intelligence (AI)—it’s the end of the tox as we know it (and I feel fine)*
The rapid progress of AI impacts diverse scientific disciplines, including toxicology, and has the potential to transform ...
Sex-related differences in delayed doxorubicin-induced cardiac dysfunction in C57BL/6 mice
Sex-related differences in delayed doxorubicin-induced cardiac dysfunction in C57BL/6 mice
Cancer survivors may experience long-term cardiovascular complications due to chemotherapeutic drugs such as doxorubicin (...
Evolution of hormesis research: a bibliometric analysis
Evolution of hormesis research: a bibliometric analysis
In recognition of the rapid progress and transformation of the research landscape of ...
Development of an adverse outcome pathway network for nephrotoxicity
Development of an adverse outcome pathway network for nephrotoxicity
Adverse outcome pathways (AOPs) were introduced in modern toxicology to provide evidence-based representations of the even...
TH-4000, a hypoxia-activated pan-HER inhibitor, shows excellent preclinical efficacy for the treatment of HER2+ breast cancer
TH-4000, a hypoxia-activated pan-HER inhibitor, shows excellent preclinical efficacy for the treatment of HER2+ breast cancer
Human epidermal growth factor receptor 2-positive (HER2+) breast cancer is correlated with poor prognosis, the current tre...
Genome-wide functional integration identified MAZ-controlled RPS14 dysregulation in hepatocellular carcinoma
Genome-wide functional integration identified MAZ-controlled RPS14 dysregulation in hepatocellular carcinoma
Chronic infection with Hepatitis B virus (HBV) significantly increases the risk of hepatocellular carcinoma (HCC), particu...
The role of ferroptosis in cardio-oncology
The role of ferroptosis in cardio-oncology
With the rapid development of new generations of antitumor therapies, the average survival time of cancer patients is expe...
Metabolic effects of nuclear receptor activation in vivo after 28-day oral exposure to three endocrine-disrupting chemicals
Metabolic effects of nuclear receptor activation in vivo after 28-day oral exposure to three endocrine-disrupting chemicals
Environmental exposure to endocrine-disrupting chemicals (EDCs) can lead to metabolic disruption, resulting in metabolic c...
27-Hydroxycholesterol inhibits trophoblast fusion during placenta development by activating PI3K/AKT/mTOR signaling pathway
27-Hydroxycholesterol inhibits trophoblast fusion during placenta development by activating PI3K/AKT/mTOR signaling pathway
Trophoblast cell syncytialization is essential for placental and fetal development. Abnormal trophoblast cell fusion leads...
Elucidating the toxicity mechanisms of organophosphate esters by adverse outcome pathway network
Elucidating the toxicity mechanisms of organophosphate esters by adverse outcome pathway network
With the widespread use of organophosphate esters (OPEs), the accumulation and toxicity effect of OPEs in biota are attrac...