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Excavatolide C/cisplatin combination induces antiproliferation and drives apoptosis and DNA damage in bladder cancer cells
Excavatolide C/cisplatin combination induces antiproliferation and drives apoptosis and DNA damage in bladder cancer cells
Excavatolide C (EXCC), a marine coral-derived compound, exhibits an antiproliferation effect on bladder cancer cells. The ...
Effects of marine biotoxins on drug-metabolizing cytochrome P450 enzymes and their regulation in mammalian cells
Effects of marine biotoxins on drug-metabolizing cytochrome P450 enzymes and their regulation in mammalian cells
Marine biotoxins are a heterogenous group of natural toxins, which are able to trigger different types of toxicological re...
PBTK model-based analysis of CYP3A4 induction and the toxicokinetics of the pyrrolizidine alkaloid retrorsine in man
PBTK model-based analysis of CYP3A4 induction and the toxicokinetics of the pyrrolizidine alkaloid retrorsine in man
Cytochrome P450 (CYP)3A4 induction by drugs and pesticides plays a critical role in the enhancement of pyrrolizidine alkal...
Formation of potentially toxic metabolites of drugs in reactions catalyzed by human drug-metabolizing enzymes
Formation of potentially toxic metabolites of drugs in reactions catalyzed by human drug-metabolizing enzymes
Data are presented on the formation of potentially toxic metabolites of drugs that are substrates of human drug metabolizi...
CircRNA: a rising therapeutic strategy for lung injury induced by pulmonary toxicants
CircRNA: a rising therapeutic strategy for lung injury induced by pulmonary toxicants
Lung injury has been a serious medical problem that requires new therapeutic approaches and biomarkers. Circular RNAs (cir...
Role of the complement system in kidney cell death induced by Loxosceles venom Sphingomyelinases D
Role of the complement system in kidney cell death induced by Loxosceles venom Sphingomyelinases D
Envenomation by Loxosceles spiders can result in local and systemic pathologies. Systemic loxoscelism, which can lead to d...
Cytogenotoxicity and inflammatory response in liver of rats exposed to different doses of cannabis nano emulsions
Cytogenotoxicity and inflammatory response in liver of rats exposed to different doses of cannabis nano emulsions
Cannabis is the most used illicit substance for recreational purposes around the world. However, it has become increasingl...
Prediction of cytochrome P450-mediated bioactivation using machine learning models and in vitro validation
Prediction of cytochrome P450-mediated bioactivation using machine learning models and in vitro validation
Cytochrome P450 (P450)-mediated bioactivation, which can lead to the hepatotoxicity through the formation of reactive meta...
Characterization of pathological changes in the olfactory system of mice exposed to methylmercury
Characterization of pathological changes in the olfactory system of mice exposed to methylmercury
Methylmercury (MeHg) is a well-known environmental neurotoxicant that causes severe brain disorders such as Minamata disea...
Demonstrating the reliability of in vivo metabolomics based chemical grouping: towards best practice
Demonstrating the reliability of in vivo metabolomics based chemical grouping: towards best practice
While grouping/read-across is widely used to fill data gaps, chemical registration dossiers are often rejected due to weak...
Flavonoids commonly induce hormetic responses
Flavonoids commonly induce hormetic responses
The present paper provides a new perspective of previously published findings by Siwak (Food Chem 141:1227–1241, 201...
ATF4 in cellular stress, ferroptosis, and cancer
ATF4 in cellular stress, ferroptosis, and cancer
Activating transcription factor 4 (ATF4), a member of the ATF/cAMP response element-binding (CREB) family, plays a critica...
In vitro and in vivo metabolic activation and hepatotoxicity of chlorzoxazone mediated by CYP3A
In vitro and in vivo metabolic activation and hepatotoxicity of chlorzoxazone mediated by CYP3A
Chlorzoxazone (CZX), a benzoxazolone derivative, has been approved for the treatment of musculoskeletal disorders to relie...
Recent advances and current challenges of new approach methodologies in developmental and adult neurotoxicity testing
Recent advances and current challenges of new approach methodologies in developmental and adult neurotoxicity testing
Adult neurotoxicity (ANT) and developmental neurotoxicity (DNT) assessments aim to understand the adverse effects and unde...
Involvement of per- and polyfluoroalkyl compounds in tumor development
Involvement of per- and polyfluoroalkyl compounds in tumor development
Per- and polyfluoroalkyl substances (PFAS) are a large group of synthetic persistent chemicals, which are used in many ind...
Elevated aerobic glycolysis driven by p62-mTOR axis promotes arsenic-induced oncogenic phenotypes in human mammary epithelial cells
Elevated aerobic glycolysis driven by p62-mTOR axis promotes arsenic-induced oncogenic phenotypes in human mammary epithelial cells
Chronic arsenic exposure is considered to increase the risk of breast cancer. p62 is a multifunctional adaptor protein tha...
Cellular senescence gene TACC3 associated with colorectal cancer risk via genetic and DNA methylated alteration
Cellular senescence gene TACC3 associated with colorectal cancer risk via genetic and DNA methylated alteration
Cell senescence genes play a vital role in the pathogenesis of colorectal cancer, a process that may involve the triggerin...
Use of human predictive patch test (HPPT) data for the classification of skin sensitization hazard and potency
Use of human predictive patch test (HPPT) data for the classification of skin sensitization hazard and potency
Since the 1940s, patch tests in healthy volunteers (Human Predictive Patch Tests, HPPTs) have been used to identify chemic...
Combined use of multiparametric high-content-screening and in vitro circadian reporter assays in neurotoxicity evaluation
Combined use of multiparametric high-content-screening and in vitro circadian reporter assays in neurotoxicity evaluation
Accumulating evidence indicates that chronic circadian rhythm disruption is associated with the development of neurodegene...
Future in the past: paternal reprogramming of offspring phenotype and the epigenetic mechanisms
Future in the past: paternal reprogramming of offspring phenotype and the epigenetic mechanisms
That certain preconceptual paternal exposures reprogram the developmental phenotypic plasticity in future generation(s) ha...
Acetaminophen overdose causes a breach of the blood–bile barrier in mice but not in rats
Acetaminophen overdose causes a breach of the blood–bile barrier in mice but not in rats
Acetaminophen (APAP) is known to cause a breach of the blood–bile barrier in mice that, via a mechanism called futil...
The acute toxicity of Novichok's degradation products using quantitative and qualitative toxicology in silico methods
The emergence of Novichok agents, potent organophosphorus nerve agents, has spurred the demand for advanced analytical met...
YES1 as a potential target to overcome drug resistance in EGFR-deregulated non-small cell lung cancer
YES1 as a potential target to overcome drug resistance in EGFR-deregulated non-small cell lung cancer
Epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) such as gefitinib and osimertinib have primarily...