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A new human autologous hepatocyte/macrophage co-culture system that mimics drug-induced liver injury–like inflammation
A new human autologous hepatocyte/macrophage co-culture system that mimics drug-induced liver injury–like inflammation
The development of in vitro hepatocyte cell culture systems is crucial for investigating drug-induced liver injury (DILI)....
Immunology and treatments of fatty liver disease
Immunology and treatments of fatty liver disease
Alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD) are two major chronic liver diseases worldwide...
The ETS domain-containing hematopoietic transcription factor PU.1 mediates the induction of arachidonate 5-lipoxygenase by multi-walled carbon nanotubes in macrophages in vitro
The ETS domain-containing hematopoietic transcription factor PU.1 mediates the induction of arachidonate 5-lipoxygenase by multi-walled carbon nanotubes in macrophages in vitro
Exposure to fibrogenic multi-walled carbon nanotubes (MWCNTs) induces the production of proinflammatory lipid mediators (L...
Cellular mechanisms of copper neurotoxicity in human, differentiated neurons
Cellular mechanisms of copper neurotoxicity in human, differentiated neurons
Copper (Cu) is an essential trace element involved in fundamental physiological processes in the human body. Even slight d...
A transcriptome-wide association study integrating multi-omics bioinformatics and Mendelian randomization reveals the prognostic value of ADAMDEC1 in colon cancer
A transcriptome-wide association study integrating multi-omics bioinformatics and Mendelian randomization reveals the prognostic value of ADAMDEC1 in colon cancer
An abundant amount of colon cancers is diagnosed every year, accounting for 9% of malignant tumors. Even with the progress...
Polybrominated diphenyl ether flame retardants inhibit growth factor-induced activation of EGFR by binding to its extracellular domain
Polybrominated diphenyl ether flame retardants inhibit growth factor-induced activation of EGFR by binding to its extracellular domain
For many years, polybrominated diphenyl ethers (PBDEs) were used as flame retardants in a large number of consumer product...
miR-451a and miR-486-5p: biomarkers for benzene-induced hematotoxicity
miR-451a and miR-486-5p: biomarkers for benzene-induced hematotoxicity
The hematopoietic system is the primary target of benzene exposure. Whether peripheral blood miRNA can serve as sensitive ...
In silico structural and mechanistic sights into the N-glycosidase mechanism of Shiga toxin
In silico structural and mechanistic sights into the N-glycosidase mechanism of Shiga toxin
Shiga toxin is the leading cause of food poisoning in the world. It is structurally similar to the plant type II ribosome-...
Impact of administration routes and dose frequency on the toxicology of SARS-CoV-2 mRNA vaccines in mice model
Impact of administration routes and dose frequency on the toxicology of SARS-CoV-2 mRNA vaccines in mice model
The increasing use of SARS-CoV-2 mRNA vaccines has raised concerns about their potential toxicological effects, necessitat...
Development of a novel in vitro respiratory sensitization assay and its application in an integrated testing strategy (ITS)
Development of a novel in vitro respiratory sensitization assay and its application in an integrated testing strategy (ITS)
Currently, evaluating respiratory sensitization is challenging with a lack of mechanistic understanding and appropriate te...
Canagliflozin differentially modulates carfilzomib-induced endoplasmic reticulum stress in multiple myeloma and endothelial cells
Canagliflozin differentially modulates carfilzomib-induced endoplasmic reticulum stress in multiple myeloma and endothelial cells
Carfilzomib (CFZ), a second-generation proteasome inhibitor, is a key treatment for multiple myeloma (MM), but its use is ...
Does a carboxamide moiety alter the toxicokinetics of synthetic cannabinoids? A study after pulmonary and intravenous administration of cumyl-5F-P7AICA to pigs
Does a carboxamide moiety alter the toxicokinetics of synthetic cannabinoids? A study after pulmonary and intravenous administration of cumyl-5F-P7AICA to pigs
Synthetic cannabinoids (SCs) are consumed as an alternative to cannabis. Novel compounds are developed by minor modificati...
Short-term repeated oral intake of low dose cannabidiol: effects on liver enzyme activity and creatinine concentration during intense exercise
Short-term repeated oral intake of low dose cannabidiol: effects on liver enzyme activity and creatinine concentration during intense exercise
The side effects and safety of cannabidiol (CBD) products are currently discussed in different contexts. Of all adverse ef...
Alterations in the proteomes of HepG2 and IHKE cells inflicted by six selected mycotoxins
Alterations in the proteomes of HepG2 and IHKE cells inflicted by six selected mycotoxins
Toxic fungal secondary metabolites, referred to as mycotoxins, emerge in moldy food and feed and constitute a potent but o...
In vitro assessment of emerging mycotoxins co-occurring in cheese: a potential health hazard
In vitro assessment of emerging mycotoxins co-occurring in cheese: a potential health hazard
Some Penicillium strains used in cheese ripening produce emerging mycotoxins, notably roquefortine C (ROQC) and cyclopiazo...
An integrated multi-omics analysis of the effects of the food processing-induced contaminant 2-monochloropropane-1,3-diol (2-MCPD) in rat heart
An integrated multi-omics analysis of the effects of the food processing-induced contaminant 2-monochloropropane-1,3-diol (2-MCPD) in rat heart
Many foods including edible oils contain 2-monochloropropane-1,3-diol (2-MCPD), a processing-induced chemical contaminant....
Towards characterization of cell culture conditions for reliable proteomic analysis: in vitro studies on A549, differentiated THP-1, and NR8383 cell lines
Towards characterization of cell culture conditions for reliable proteomic analysis: in vitro studies on A549, differentiated THP-1, and NR8383 cell lines
Proteomic investigations result in high dimensional datasets, but integration or comparison of different studies is hamper...
Research advances on CaMKs-mediated neurodevelopmental injury
Research advances on CaMKs-mediated neurodevelopmental injury
Calcium/calmodulin-dependent protein kinases (CaMKs) are important proteins in the calcium signaling cascade response path...
MicroRNAs in fluorosis pathogenesis: impact on dental, skeletal, and soft tissues
MicroRNAs in fluorosis pathogenesis: impact on dental, skeletal, and soft tissues
Fluoride-induced toxicity (fluorosis) poses a significant health concern globally, affecting millions of individuals. Unde...
Fullerene and fullerene whisker are not carcinogenic to the lungs and pleura in rat long-term study after 2-week intra-tracheal intrapulmonary administration
Fullerene and fullerene whisker are not carcinogenic to the lungs and pleura in rat long-term study after 2-week intra-tracheal intrapulmonary administration
Fullerene whiskers (FLW)s are thin rod-like structures composed of C60 and C70 fullerene (FL). The shape of FLWs suggests ...
Interactions between polycyclic aromatic hydrocarbons and genetic variants in the cGAS–STING pathway affect the risk of colorectal cancer
Interactions between polycyclic aromatic hydrocarbons and genetic variants in the cGAS–STING pathway affect the risk of colorectal cancer
The cGAS–STING pathway plays an essential role in the activation of tumor immune cells. Polycyclic aromatic hydrocar...
FGTN: Fragment-based graph transformer network for predicting reproductive toxicity
FGTN: Fragment-based graph transformer network for predicting reproductive toxicity
Reproductive toxicity is one of the important issues in chemical safety. Traditional laboratory testing methods are costly...
Neutralizing chimeric heavy-chain antibody targeting the L-HN domain of Clostridium botulinum neurotoxin type F
Neutralizing chimeric heavy-chain antibody targeting the L-HN domain of Clostridium botulinum neurotoxin type F
Botulinum toxin (BoNT) from Clostridium botulinum is the most toxic biotoxin known and is also an important bioterrorism a...
Development of two ultra-sensitive UHPLC–QqQ-MS/MS methods for the simultaneous determination of hydroxyzine and its active metabolite (cetirizine) in human blood: applications to real cases of forensic toxicology
Development of two ultra-sensitive UHPLC–QqQ-MS/MS methods for the simultaneous determination of hydroxyzine and its active metabolite (cetirizine) in human blood: applications to real cases of forensic toxicology
Both postmortem toxicological and medical-forensic examinations are very important in the case of analyzing various types ...
Comparative case study on NAMs: towards enhancing specific target organ toxicity analysis
Comparative case study on NAMs: towards enhancing specific target organ toxicity analysis
Traditional risk assessment methodologies in toxicology have relied upon animal testing, despite concerns regarding inters...
How contaminated is flatfish living near World Wars’ munition dumping sites with energetic compounds?
How contaminated is flatfish living near World Wars’ munition dumping sites with energetic compounds?
Seas worldwide are threatened by an emerging source of pollution as millions of tons of warfare materials were dumped afte...
Optimized methods for measuring competitive binding of chemical substances to thyroid hormone distributor proteins transthyretin and thyroxine binding globulin
Optimized methods for measuring competitive binding of chemical substances to thyroid hormone distributor proteins transthyretin and thyroxine binding globulin
Transthyretin (TTR) and thyroxine-binding globulin (TBG) are two major thyroid hormone (TH) distributor proteins in human ...
Hepatic and metabolic outcomes induced by sub-chronic exposure to polystyrene microplastics in mice
Hepatic and metabolic outcomes induced by sub-chronic exposure to polystyrene microplastics in mice
Microplastics (MPs) have attracted significant attention due to their global distribution in living environments. Although...
Effects of chronic insecticide exposure on neuronal network development in vitro in rat cortical cultures
Effects of chronic insecticide exposure on neuronal network development in vitro in rat cortical cultures
Developmental exposure to carbamates, organophosphates, and pyrethroids has been associated with impaired neurodevelopment...
Effects of novel flame retardants tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) and triphenyl phosphate (TPhP) on function and homeostasis in human and rat pancreatic beta-cell lines
Effects of novel flame retardants tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) and triphenyl phosphate (TPhP) on function and homeostasis in human and rat pancreatic beta-cell lines
Despite the fact that environmental pollution has been implicated in the global rise of diabetes, the research on the impa...
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