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Evaluation of functional candidate biomarkers of non-genotoxic hepatocarcinogenicity in human liver spheroid co-cultures
Evaluation of functional candidate biomarkers of non-genotoxic hepatocarcinogenicity in human liver spheroid co-cultures
Validated in vitro assays for testing non-genotoxic carcinogenic potential of chemicals are currently not available. Conse...
Induction of clastogenesis and gene mutations by carbamazepine (at its therapeutically effective serum levels) in mammalian cells and the dependence on human CYP2B6 enzyme activity
Induction of clastogenesis and gene mutations by carbamazepine (at its therapeutically effective serum levels) in mammalian cells and the dependence on human CYP2B6 enzyme activity
Carbamazepine (CBZ, an antiepileptic) is metabolized by multiple CYP enzymes to its epoxide and hydroxides; however, wheth...
Organotin mixtures reveal interactions that modulate adipogenic differentiation in 3T3-L1 preadipocytes
Organotin mixtures reveal interactions that modulate adipogenic differentiation in 3T3-L1 preadipocytes
Organotin chemicals (butyltins and phenyltins) are the most widely used organometallic chemicals worldwide and are used in...
Effect of N-acetyltransferase 2 genetic polymorphism on 4,4′-methylenebis(2-chloroaniline)-induced genotoxicity and oxidative stress
Effect of N-acetyltransferase 2 genetic polymorphism on 4,4′-methylenebis(2-chloroaniline)-induced genotoxicity and oxidative stress
4,4′-Methylenebis(2-chloroaniline) or MOCA is an aromatic amine used primarily in polyurethane and rubber industry. ...
A new cell line based coculture system for skin sensitisation testing in one single assay using T cells, aryl hydrocarbon receptor knockout, and co-inhibitory blockage
A new cell line based coculture system for skin sensitisation testing in one single assay using T cells, aryl hydrocarbon receptor knockout, and co-inhibitory blockage
Established in vitro assays for regulatory testing of skin sensitisation partly suffer from only moderate sensitivity, spe...
Application of toxicology in silico methods for prediction of acute toxicity (LD50) for Novichoks
Application of toxicology in silico methods for prediction of acute toxicity (LD50) for Novichoks
Novichoks represent the fourth generation of chemical warfare agents with paralytic and convulsive effects, produced cland...
Pharmacogenetics in early drug development for non-alcoholic steatohepatitis: missed chances and future opportunities
Pharmacogenetics in early drug development for non-alcoholic steatohepatitis: missed chances and future opportunities
Amangurbanova M, Huang DQ, Loomba R (2023) Review article: the role of HSD17B13 on global epidemiology, natural history, p...
The tick saliva peptide HIDfsin2 promotes the tick-borne virus SFTSV replication in vitro by enhancing p38 signal pathway
The tick saliva peptide HIDfsin2 promotes the tick-borne virus SFTSV replication in vitro by enhancing p38 signal pathway
Pathogens co-evolved with ticks to facilitate blood collection and pathogen transmission. Although tick saliva was recentl...
Metabolic impact of genetic and chemical ADP/ATP carrier inhibition in renal proximal tubule epithelial cells
Metabolic impact of genetic and chemical ADP/ATP carrier inhibition in renal proximal tubule epithelial cells
Mitochondrial dysfunction is pivotal in drug-induced acute kidney injury (AKI), but the underlying mechanisms remain large...
Health risks associated with dietary cadmium exposure
Health risks associated with dietary cadmium exposure
Satarug et al. (2023) described the upper limit of tolerable cadmium (Cd) intake from die...
ROS-induced lipid peroxidation modulates cell death outcome: mechanisms behind apoptosis, autophagy, and ferroptosis
ROS-induced lipid peroxidation modulates cell death outcome: mechanisms behind apoptosis, autophagy, and ferroptosis
Reactive oxygen species (ROS) mediate lipid peroxidation and produce 4-hydroxynonenal and other related products, which pl...
Exposure to dietary fatty acids oleic and palmitic acid alters structure and mechanotransduction of intestinal cells in vitro
Exposure to dietary fatty acids oleic and palmitic acid alters structure and mechanotransduction of intestinal cells in vitro
Intestinal cells are continuously exposed to food constituents while adapting to peristaltic movement and fluid shear stre...
Dimeric oxyberberine CT4-1 targets LINC02331 to induce cytotoxicity and inhibit chemoresistance via suppressing Wnt/β-catenin signaling in hepatocellular carcinoma
Dimeric oxyberberine CT4-1 targets LINC02331 to induce cytotoxicity and inhibit chemoresistance via suppressing Wnt/β-catenin signaling in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a type of cancer characterized by high recurrence rates. Overcoming chemoresistance can ...
Is there a relationship between orthodontic treatment and DNA damage? The relevance of metal ion accumulation in oral mucosa cells
Is there a relationship between orthodontic treatment and DNA damage? The relevance of metal ion accumulation in oral mucosa cells
Bonassi S, Coskun E, Ceppi M, Lando C, Bolognesi C, Burgaz S, Holland N, Kirsh-Volders M, Knasmueller S, Zeiger E, Carneso...
Substance abuse and neurodegenerative diseases: focus on ferroptosis
Substance abuse and neurodegenerative diseases: focus on ferroptosis
Psychostimulants and alcohol are widely abused substances with the adverse effects on global public health. Substance abus...
Systematic review of genotoxicity induced by occupational exposure to antineoplastic drugs
Systematic review of genotoxicity induced by occupational exposure to antineoplastic drugs
With increasing numbers of cancer cases, the use of antineoplastic agents is expected to rise. This will be accompanied by...
Effects of dose and human N-acetyltransferase 1 genetic polymorphism in benzidine metabolism and genotoxicity
Effects of dose and human N-acetyltransferase 1 genetic polymorphism in benzidine metabolism and genotoxicity
Benzidine undergoes N-acetylation and following CYP1A2-catalyzed N-hydroxylation undergoes O-acetylation catalyzed by N-ac...
Next generation risk assessment of human exposure to estrogens using safe comparator compound values based on in vitro bioactivity assays
Next generation risk assessment of human exposure to estrogens using safe comparator compound values based on in vitro bioactivity assays
In next generation risk assessment (NGRA), the Dietary Comparator Ratio (DCR) can be used to assess the safety of chemical...
Correction: In memoriam Thomas Gebel
Correction: In memoriam Thomas Gebel
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which ...
Understanding the molecular mechanisms of statin pleiotropic effects
Understanding the molecular mechanisms of statin pleiotropic effects
Statins represent the cornerstone of pharmacotherapy for the prevention of atherosclerotic cardiovascular disease. These m...
ECHA ARN documents: chemical grouping without a toxicological rationale
ECHA ARN documents: chemical grouping without a toxicological rationale
The EU chemical strategy for sustainability (CSS) plans to use chemical grouping to “prioritise (…) substances...
Off-target activity of NBOMes and NBOMe analogs at the µ opioid receptor
Off-target activity of NBOMes and NBOMe analogs at the µ opioid receptor
New psychoactive substances (NPS) are introduced on the illicit drug market at a rapid pace. Their molecular targets are o...
A review of cardiovascular effects and underlying mechanisms of legacy and emerging per- and polyfluoroalkyl substances (PFAS)
A review of cardiovascular effects and underlying mechanisms of legacy and emerging per- and polyfluoroalkyl substances (PFAS)
Cardiovascular disease (CVD) poses the leading threats to human health and life, and their occurrence and severity are ass...
Modernizing persistence–bioaccumulation–toxicity (PBT) assessment with high throughput animal-free methods
Modernizing persistence–bioaccumulation–toxicity (PBT) assessment with high throughput animal-free methods
The assessment of persistence (P), bioaccumulation (B), and toxicity (T) of a chemical is a crucial first step at ensuring...
Maternal exposure to multiple mycotoxins and adverse pregnancy outcomes: a prospective cohort study in rural Bangladesh
Maternal exposure to multiple mycotoxins and adverse pregnancy outcomes: a prospective cohort study in rural Bangladesh
There is limited and inconsistent evidence, primarily from cross-sectional studies, linking mycotoxins to adverse birth ou...
In vitro to in vivo extrapolation and high-content imaging for simultaneous characterization of chemically induced liver steatosis and markers of hepatotoxicity
In vitro to in vivo extrapolation and high-content imaging for simultaneous characterization of chemically induced liver steatosis and markers of hepatotoxicity
Chemically induced steatosis is characterized by lipid accumulation associated with mitochondrial dysfunction, oxidative s...
US regulations to curb alleged cancer causes are ineffectual and compromised by scientific, constitutional and ethical violations
US regulations to curb alleged cancer causes are ineffectual and compromised by scientific, constitutional and ethical violations
The 1958 Delaney amendment to the Federal Food Drug and Cosmetics Act prohibited food additives causing cancer in animals ...
Genetic variants of SOS2, MAP2K1 and RASGRF2 in the RAS pathway genes predict survival of HBV-related hepatocellular carcinoma patients
Genetic variants of SOS2, MAP2K1 and RASGRF2 in the RAS pathway genes predict survival of HBV-related hepatocellular carcinoma patients
The RAS pathway participates in the cascade of proliferation and cell division process, and the activated RAS pathway can ...
Metabolomics-based strategy to assess drug hepatotoxicity and uncover the mechanisms of hepatotoxicity involved
Metabolomics-based strategy to assess drug hepatotoxicity and uncover the mechanisms of hepatotoxicity involved
Toxicity studies, among them hepatotoxicity, are key throughout preclinical stages of drug development to minimise undesir...
A comparison of the chemo- and radiotoxicity of thorium and uranium at different enrichment grades
A comparison of the chemo- and radiotoxicity of thorium and uranium at different enrichment grades
Uranium and thorium are heavy metals, and all of their isotopes are radioactive, so it is impossible to study chemical eff...
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