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p21-activated kinase 1 (PAK1) as a therapeutic target for cardiotoxicity
p21-activated kinase 1 (PAK1) as a therapeutic target for cardiotoxicity
The p21-activated kinase 1 (PAK1), an effector protein of the small G protein Rac and cell division cycle protein 42 (Cdc4...
Ecstasy metabolites and monoamine neurotransmitters upshift the Na+/K+ ATPase activity in mouse brain synaptosomes
Ecstasy metabolites and monoamine neurotransmitters upshift the Na+/K+ ATPase activity in mouse brain synaptosomes
3,4-Methylenedioximethamphetamine (MDMA; “ecstasy”) is a psychotropic drug with well-known neurotoxic effects ...
Colchicine overdose impairs the capacity of Kupffer cells to clear foreign particles and endotoxins
Colchicine overdose impairs the capacity of Kupffer cells to clear foreign particles and endotoxins
Colchicine is an anti-inflammatory drug with a narrow therapeutic index. Its binding to tubulin prevents microtubule polym...
In vitro models to detect in vivo bile acid changes induced by antibiotics
In vitro models to detect in vivo bile acid changes induced by antibiotics
Bile acid homeostasis plays an important role in many biological activities through the bile–liver–gut axis. I...
Study of the roles of cytochrome P450 (CYPs) in the metabolism and cytotoxicity of perhexiline
Study of the roles of cytochrome P450 (CYPs) in the metabolism and cytotoxicity of perhexiline
Perhexiline is a prophylactic antianginal agent developed in the 1970s. Although, therapeutically, it remained a success, ...
Predictive assays for craniofacial malformations: evaluation in Xenopus laevis embryos exposed to triadimefon
Predictive assays for craniofacial malformations: evaluation in Xenopus laevis embryos exposed to triadimefon
Craniofacial defects are one of the most frequent abnormalities at birth, but their experimental evaluation in animal mode...
An artificial intelligence approach for predicting cardiotoxicity in breast cancer patients receiving anthracycline
An artificial intelligence approach for predicting cardiotoxicity in breast cancer patients receiving anthracycline
Although anti-cancer therapy-induced cardiotoxicity is known, until now it lacks a reliable risk predictive model of the s...
Toxicokinetics and metabolism of deoxynivalenol in animals and humans
Toxicokinetics and metabolism of deoxynivalenol in animals and humans
Deoxynivalenol (DON) is the most widespread mycotoxin in food and feedstuffs, posing a persistent health threat to humans ...
Proteomic analysis of hepatic effects of phenobarbital in mice with humanized liver
Proteomic analysis of hepatic effects of phenobarbital in mice with humanized liver
Activation of the constitutive androstane receptor (CAR) may induce adaptive but also adverse effects in rodent liver, inc...
Ingestion of titanium dioxide nanoparticles: a definite health risk for consumers and their progeny
Ingestion of titanium dioxide nanoparticles: a definite health risk for consumers and their progeny
Titanium dioxide (TiO2) is one of the most commonly used nanomaterials in the world. Additive E171, which is used in the f...
How to avoid misinterpretation of dual reporter gene assay data affected by cell damage
How to avoid misinterpretation of dual reporter gene assay data affected by cell damage
The activity of nuclear receptors (e.g., pregnane x receptor, PXR) can be assessed by luminescence-based dual reporter gen...
Anti-epileptic Kunitz-like peptides discovered in the branching coral Acropora digitifera through transcriptomic analysis
Anti-epileptic Kunitz-like peptides discovered in the branching coral Acropora digitifera through transcriptomic analysis
Approximately 50 million people are suffering from epilepsy worldwide. Corals have been used for treating epilepsy in trad...
Are the current commercially available oximes capable of reactivating acetylcholinesterase inhibited by the nerve agents of the A-series?
Are the current commercially available oximes capable of reactivating acetylcholinesterase inhibited by the nerve agents of the A-series?
The misuse of novichok agents in assassination attempts has been reported in the international media since 2018. These rel...
Mouse precision-cut liver slices as an ex vivo model to study drug-induced cholestasis
Mouse precision-cut liver slices as an ex vivo model to study drug-induced cholestasis
Drugs are often withdrawn from the market due to the manifestation of drug-induced liver injury (DILI) in patients. Drug-i...
A new approach to the classification of carcinogenicity
A new approach to the classification of carcinogenicity
Concern over substances that may cause cancer has led to various classification schemes to recognize carcinogenic threats ...
Ferroptosis as a mechanism of non-ferrous metal toxicity
Ferroptosis as a mechanism of non-ferrous metal toxicity
Ferroptosis is a recently discovered form of regulated cell death, implicated in multiple pathologies. Given that the toxi...
Excretion time courses of lambda-cyhalothrin metabolites in the urine of strawberry farmworkers and effect of coexposure with captan
Excretion time courses of lambda-cyhalothrin metabolites in the urine of strawberry farmworkers and effect of coexposure with captan
There are limited literature data on the impact of coexposure on the toxicokinetics of pesticides in agricultural workers....
Genotoxicity of methyl acrylate and ethyl acrylate and its relationship with glutathione
Genotoxicity of methyl acrylate and ethyl acrylate and its relationship with glutathione
Methyl acrylate (MA) and ethyl acrylate (EA) had previously tested positive for mutagenicity in vitro, but in vivo studies...
Exposure of intestinal explants to NX, but not to DON, enriches the secretome in mitochondrial proteins
Exposure of intestinal explants to NX, but not to DON, enriches the secretome in mitochondrial proteins
NX is a type A trichothecene produced by Fusarium graminearum with limited information on its toxicity. NX is structurally...