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In vitro assessment of emerging mycotoxins co-occurring in cheese: a potential health hazard
In vitro assessment of emerging mycotoxins co-occurring in cheese: a potential health hazard
Some Penicillium strains used in cheese ripening produce emerging mycotoxins, notably roquefortine C (ROQC) and cyclopiazo...
An integrated multi-omics analysis of the effects of the food processing-induced contaminant 2-monochloropropane-1,3-diol (2-MCPD) in rat heart
An integrated multi-omics analysis of the effects of the food processing-induced contaminant 2-monochloropropane-1,3-diol (2-MCPD) in rat heart
Many foods including edible oils contain 2-monochloropropane-1,3-diol (2-MCPD), a processing-induced chemical contaminant....
Towards characterization of cell culture conditions for reliable proteomic analysis: in vitro studies on A549, differentiated THP-1, and NR8383 cell lines
Towards characterization of cell culture conditions for reliable proteomic analysis: in vitro studies on A549, differentiated THP-1, and NR8383 cell lines
Proteomic investigations result in high dimensional datasets, but integration or comparison of different studies is hamper...
Research advances on CaMKs-mediated neurodevelopmental injury
Research advances on CaMKs-mediated neurodevelopmental injury
Calcium/calmodulin-dependent protein kinases (CaMKs) are important proteins in the calcium signaling cascade response path...
MicroRNAs in fluorosis pathogenesis: impact on dental, skeletal, and soft tissues
MicroRNAs in fluorosis pathogenesis: impact on dental, skeletal, and soft tissues
Fluoride-induced toxicity (fluorosis) poses a significant health concern globally, affecting millions of individuals. Unde...
Fullerene and fullerene whisker are not carcinogenic to the lungs and pleura in rat long-term study after 2-week intra-tracheal intrapulmonary administration
Fullerene and fullerene whisker are not carcinogenic to the lungs and pleura in rat long-term study after 2-week intra-tracheal intrapulmonary administration
Fullerene whiskers (FLW)s are thin rod-like structures composed of C60 and C70 fullerene (FL). The shape of FLWs suggests ...
Interactions between polycyclic aromatic hydrocarbons and genetic variants in the cGAS–STING pathway affect the risk of colorectal cancer
Interactions between polycyclic aromatic hydrocarbons and genetic variants in the cGAS–STING pathway affect the risk of colorectal cancer
The cGAS–STING pathway plays an essential role in the activation of tumor immune cells. Polycyclic aromatic hydrocar...
FGTN: Fragment-based graph transformer network for predicting reproductive toxicity
FGTN: Fragment-based graph transformer network for predicting reproductive toxicity
Reproductive toxicity is one of the important issues in chemical safety. Traditional laboratory testing methods are costly...
Neutralizing chimeric heavy-chain antibody targeting the L-HN domain of Clostridium botulinum neurotoxin type F
Neutralizing chimeric heavy-chain antibody targeting the L-HN domain of Clostridium botulinum neurotoxin type F
Botulinum toxin (BoNT) from Clostridium botulinum is the most toxic biotoxin known and is also an important bioterrorism a...
Development of two ultra-sensitive UHPLC–QqQ-MS/MS methods for the simultaneous determination of hydroxyzine and its active metabolite (cetirizine) in human blood: applications to real cases of forensic toxicology
Development of two ultra-sensitive UHPLC–QqQ-MS/MS methods for the simultaneous determination of hydroxyzine and its active metabolite (cetirizine) in human blood: applications to real cases of forensic toxicology
Both postmortem toxicological and medical-forensic examinations are very important in the case of analyzing various types ...
Comparative case study on NAMs: towards enhancing specific target organ toxicity analysis
Comparative case study on NAMs: towards enhancing specific target organ toxicity analysis
Traditional risk assessment methodologies in toxicology have relied upon animal testing, despite concerns regarding inters...
How contaminated is flatfish living near World Wars’ munition dumping sites with energetic compounds?
How contaminated is flatfish living near World Wars’ munition dumping sites with energetic compounds?
Seas worldwide are threatened by an emerging source of pollution as millions of tons of warfare materials were dumped afte...
Optimized methods for measuring competitive binding of chemical substances to thyroid hormone distributor proteins transthyretin and thyroxine binding globulin
Optimized methods for measuring competitive binding of chemical substances to thyroid hormone distributor proteins transthyretin and thyroxine binding globulin
Transthyretin (TTR) and thyroxine-binding globulin (TBG) are two major thyroid hormone (TH) distributor proteins in human ...
Hepatic and metabolic outcomes induced by sub-chronic exposure to polystyrene microplastics in mice
Hepatic and metabolic outcomes induced by sub-chronic exposure to polystyrene microplastics in mice
Microplastics (MPs) have attracted significant attention due to their global distribution in living environments. Although...
Effects of chronic insecticide exposure on neuronal network development in vitro in rat cortical cultures
Effects of chronic insecticide exposure on neuronal network development in vitro in rat cortical cultures
Developmental exposure to carbamates, organophosphates, and pyrethroids has been associated with impaired neurodevelopment...
Effects of novel flame retardants tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) and triphenyl phosphate (TPhP) on function and homeostasis in human and rat pancreatic beta-cell lines
Effects of novel flame retardants tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) and triphenyl phosphate (TPhP) on function and homeostasis in human and rat pancreatic beta-cell lines
Despite the fact that environmental pollution has been implicated in the global rise of diabetes, the research on the impa...
Revisiting cadmium-induced toxicity in the male reproductive system: an update
Revisiting cadmium-induced toxicity in the male reproductive system: an update
Heavy metals like cadmium (Cd) are one of the main environmental pollutants, with no biological role in the human body. Cd...
Effects of metal oxide nanoparticles on healthy and psoriasis-like human epidermal keratinocytes in vitro
Effects of metal oxide nanoparticles on healthy and psoriasis-like human epidermal keratinocytes in vitro
The use of metal oxide nanoparticles (NPs) in skincare products has significantly increased human skin exposure, raising s...
Monitoring of per- and polyfluoroalkyl substances (PFAS) in human blood samples collected in three regions with known PFAS releases in the environment and three control regions in South Germany
Monitoring of per- and polyfluoroalkyl substances (PFAS) in human blood samples collected in three regions with known PFAS releases in the environment and three control regions in South Germany
Per- and polyfluoroalkyl substances (PFAS) are known as persistent and bioaccumulative chemicals. The present paper descri...
Unrevealing the mechanisms behind the cardioprotective effect of wheat polyphenolics
Unrevealing the mechanisms behind the cardioprotective effect of wheat polyphenolics
Cardiovascular diseases pose a major threat to both life expectancy and quality of life worldwide, and a concerning level ...
In vivo pharmacokinetic, pharmacodynamic and brain concentration comparison of fentanyl and para-fluorofentanyl in rats
In vivo pharmacokinetic, pharmacodynamic and brain concentration comparison of fentanyl and para-fluorofentanyl in rats
In 2022, para-fluorofentanyl (pFF) rose to the 6th most reported drug and the most reported fentanyl analog in the United ...
Thiopurine S‑methyltransferase- and indolethylamine N‑methyltransferase-mediated formation of methylated tellurium compounds from tellurite
Thiopurine S‑methyltransferase- and indolethylamine N‑methyltransferase-mediated formation of methylated tellurium compounds from tellurite
Tellurium (Te) is a metalloid widely used in various industries. However, its toxicological impact on humans is poorly und...
Innate immune regulation in inflammation resolution and liver regeneration in drug-induced liver injury
Innate immune regulation in inflammation resolution and liver regeneration in drug-induced liver injury
Drug-induced liver injury (DILI) is an acute liver injury that poses a significant threat to human health. In severe cases...
Mechanistic insight of neurodegeneration due to micro/nano-plastic-induced gut dysbiosis
Mechanistic insight of neurodegeneration due to micro/nano-plastic-induced gut dysbiosis
Despite offering significant conveniences, plastic materials contribute substantially in developing environmental hazards ...
Standardization and optimization of the hiPSC-based PluriLum assay for detection of embryonic and developmental toxicants
Standardization and optimization of the hiPSC-based PluriLum assay for detection of embryonic and developmental toxicants
New approach methodologies (NAMs) for predicting embryotoxicity and developmental toxicity are urgently needed for generat...
Animal-free safety assessment of chemicals: an innovation system perspective
Animal-free safety assessment of chemicals: an innovation system perspective
This perspective paper, which is the result of a collaborative effort between toxicologists and scholars in innovation and...
Minimum information for reporting on the TEER (trans-epithelial/endothelial electrical resistance) assay (MIRTA)
Minimum information for reporting on the TEER (trans-epithelial/endothelial electrical resistance) assay (MIRTA)
Standard information reporting helps to ensure that assay conditions and data are consistently reported and to facilitate ...
Arylacetamide deacetylase regulates hepatic iron homeostasis to protect against carbon tetrachloride-induced ferroptosis
Arylacetamide deacetylase regulates hepatic iron homeostasis to protect against carbon tetrachloride-induced ferroptosis
Arylacetamide deacetylase (AADAC) catalyzes the hydrolysis of small molecules containing ester and amide bonds. Recently, ...
Internal exposure to heat-induced food contaminants in omnivores, vegans and strict raw food eaters: biomarkers of exposure to 2- and 3-monochloropropanediol (urinary excretion) and glycidol (hemoglobin adduct N-2,3-dihydroxypropyl-Val)
Internal exposure to heat-induced food contaminants in omnivores, vegans and strict raw food eaters: biomarkers of exposure to 2- and 3-monochloropropanediol (urinary excretion) and glycidol (hemoglobin adduct N-2,3-dihydroxypropyl-Val)
Fatty acid esters of 2/3-monochloropropanediol (2/3-MCPD) and glycidol are formed mainly during heat processing (deodoriza...
Discovery of the Alternaria mycotoxins alterperylenol and altertoxin I as novel immunosuppressive and antiestrogenic compounds in vitro
Discovery of the Alternaria mycotoxins alterperylenol and altertoxin I as novel immunosuppressive and antiestrogenic compounds in vitro
Alternaria mycotoxins may pose significant challenges to food safety and public health due to the wide spectrum of reporte...
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