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DEK regulates B-cell proliferative capacity and is associated with aggressive disease in low-grade B-cell lymphomas
DEK regulates B-cell proliferative capacity and is associated with aggressive disease in low-grade B-cell lymphomas
This study sheds light on the pivotal role of the oncoprotein DEK in B-cell lymphoma. We reveal DEK expression correlates ...
Phase II study of novel CXCR2 agonist and Plerixafor for rapid stem cell mobilization in patients with multiple myeloma
Phase II study of novel CXCR2 agonist and Plerixafor for rapid stem cell mobilization in patients with multiple myeloma
MGTA-145 or GROβT, a CXCR2 agonist, has shown promising activity for hematopoietic stem cell (HSC) mobilization with ...
MYC-rearranged mature B-cell lymphomas in children and young adults are molecularly Burkitt Lymphoma
MYC-rearranged mature B-cell lymphomas in children and young adults are molecularly Burkitt Lymphoma
Aggressive B-cell non-Hodgkin lymphomas (NHL) in children, adolescents, and young adults (CAYA) include Burkitt lymphoma (...
Discontinuation of maintenance therapy in multiple myeloma guided by multimodal measurable residual disease negativity (MRD2STOP)
Discontinuation of maintenance therapy in multiple myeloma guided by multimodal measurable residual disease negativity (MRD2STOP)
MRD2STOP is a pragmatic trial evaluating maintenance therapy cessation guided by measurable residual disease (MRD) negativ...
AXL as immune regulator and therapeutic target in Acute Myeloid Leukemia: from current progress to novel strategies
AXL as immune regulator and therapeutic target in Acute Myeloid Leukemia: from current progress to novel strategies
Until recently, treatment options for patients diagnosed with Acute Myeloid Leukemia (AML) were limited and predominantly ...
Ruxolitinib for steroid-refractory chronic graft-versus-host disease: Japanese subgroup analysis of REACH3 study
Ruxolitinib for steroid-refractory chronic graft-versus-host disease: Japanese subgroup analysis of REACH3 study
Ruxolitinib, a Janus kinase (JAK1–JAK2) inhibitor, has demonstrated safety and efficacy in patients with graft-versu...
Long-term safety and efficacy of ropeginterferon alfa-2b in Japanese patients with polycythemia vera
Long-term safety and efficacy of ropeginterferon alfa-2b in Japanese patients with polycythemia vera
Ropeginterferon alfa-2b (ropegIFN), a new-generation interferon-based agent, has been approved in Japan for patients with ...
The triple A (AAA) model globally recapitulates adverse outcomes in essential thrombocythemia
The triple A (AAA) model globally recapitulates adverse outcomes in essential thrombocythemia
Essential thrombocythemia (ET) is a myeloproliferative neoplasm (MPN) whose clinical course is often ...
Therapeutic targets of armored chimeric antigen receptor T cells navigating the tumor microenvironment
Therapeutic targets of armored chimeric antigen receptor T cells navigating the tumor microenvironment
Chimeric antigen receptor (CAR) T cell therapy, which targets tumors with high specificity through the recognition of part...
DLL3 as a potential diagnostic and therapeutic target in neuroendocrine neoplasms: A narrative review
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Current management of cervical cancer in women living with HIV
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Long-term safety and effectiveness of romiplostim for chronic idiopathic thrombocytopenic purpura in real-world settings
Long-term safety and effectiveness of romiplostim for chronic idiopathic thrombocytopenic purpura in real-world settings
Idiopathic thrombocytopenic purpura (ITP), an autoimmune hematologic disorder characterized by severe platelet count reduc...
Silent inactivation of asparaginase in Japan: results of the prospective ALL-ASP19 trial
Silent inactivation of asparaginase in Japan: results of the prospective ALL-ASP19 trial
Silent inactivation (SI) of L-asparaginase (ASP) is a phenomenon by which a neutralizing antibody for ASP (AAA) decreases ...
Relationship between hemoglobinopathies and male infertility: a scoping review
Relationship between hemoglobinopathies and male infertility: a scoping review
Infertility is a common issue that threatens couples worldwide. Infertility can result from the male or female partner alo...
Targeting hepcidin in colorectal cancer triggers a TNF-dependent-gasdermin E-driven immunogenic cell death response
Targeting hepcidin in colorectal cancer triggers a TNF-dependent-gasdermin E-driven immunogenic cell death response
Interactions between colorectal cancer (CRC) cells and the noncancerous cells in the tumor microenvironment (TME) induce m...