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Fedratinib for the treatment of myelofibrosis: a critical appraisal of clinical trial and “real-world” data
Fedratinib is a predominantly JAK2 inhibitor that has shown efficacy in untreated and ruxolitinib-exposed patients with my...
Post-transplant TKIs for Ph+ ALL: practices to date and clinical significance
Post-transplant TKIs for Ph+ ALL: practices to date and clinical significance
Post-transplant tyrosine kinase inhibitors (TKIs) show promise in preventing relapse after allogeneic hematopoietic cell t...
Role of Population Based Studies in Advancing our Knowledge of Myelodysplastic Syndromes
Role of Population Based Studies in Advancing our Knowledge of Myelodysplastic Syndromes
Myelodysplastic syndromes (MDS) are myeloid neoplasms characterized by high molecular and genomic heterogeneity. According...
Construction and characterization of chimeric FcγR T cells for universal T cell therapy
Construction and characterization of chimeric FcγR T cells for universal T cell therapy
Several approaches are being explored for engineering off-the-shelf chimeric antigen receptor (CAR) T cells. In this study...
Exploring the impact of interferon-gamma single nucleotide polymorphisms on HTLV-1 infection: Unraveling genetic influences in viral pathogenesis
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The emerging landscape and future perspective of SCLC transformation: From molecular mechanisms to therapeutic strategies
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JSH practical guidelines for hematological malignancies, 2023: leukemia-6. Myelodysplastic syndromes (MDS)
JSH practical guidelines for hematological malignancies, 2023: leukemia-6. Myelodysplastic syndromes (MDS)
Conflict of interest YM has received per diem, including speaking f...
Current advances and future prospects of blood-based techniques for identifying benign and malignant pulmonary nodules
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Efficacy and safety of polatuzumab-vedotin plus bendamustine and rituximab in patients with relapsed/refractory diffuse large B-cell lymphoma: A systematic review and meta-analysis
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Correlates and Consequences of Clonal Hematopoiesis Expansion Rate: A 15-Year Longitudinal Study of 6,986 Women
Correlates and Consequences of Clonal Hematopoiesis Expansion Rate: A 15-Year Longitudinal Study of 6,986 Women
medRxiv - The Preprint Server for Health Sciences
Biomechanics in the tumor microenvironment: from biological functions to potential clinical applications
Biomechanics in the tumor microenvironment: from biological functions to potential clinical applications
Immune checkpoint therapies have spearheaded drug innovation over the last decade, propelling cancer treatments toward a n...
Combinatorial functionomics identifies HDAC6-dependent molecular vulnerability of radioresistant head and neck cancer
Combinatorial functionomics identifies HDAC6-dependent molecular vulnerability of radioresistant head and neck cancer
Radiotherapy is the primary treatment modality for most head and neck cancers (HNCs). Despite the addition of chemotherapy...
Tunneling nanotubes between bone marrow stromal cells support transmitophagy and resistance to apoptosis in myeloma
Tunneling nanotubes between bone marrow stromal cells support transmitophagy and resistance to apoptosis in myeloma
Multiple myeloma (MM) flourishes within the bone marrow (BM), a metabolicall...
Diverse real-life outcomes after intensive risk-adapted therapy for 1034 AML patients from the CETLAM Group
Diverse real-life outcomes after intensive risk-adapted therapy for 1034 AML patients from the CETLAM Group
Given the heterogeneity of acute myeloid leukemia patients, it is necessary to identify patients considered fit for intens...
Whole genome sequencing and the genetics of extramedullary disease in multiple myeloma
Whole genome sequencing and the genetics of extramedullary disease in multiple myeloma
Extramedullary disease (EMD) in multiple myeloma (MM) affects up to 20% of p...
Treatment with obinutuzumab plus venetoclax reshapes the TRB repertoire of CLL patients
Treatment with obinutuzumab plus venetoclax reshapes the TRB repertoire of CLL patients
The TRB repertoire was characterized in 137 samples, representing 59 patients from the HOVON-139/GIVE trial at trial entry...
Clinical practice guidelines for management of disseminated intravascular coagulation in Japan 2024. Part 3: solid cancers and vascular abnormalities
Clinical practice guidelines for management of disseminated intravascular coagulation in Japan 2024. Part 3: solid cancers and vascular abnormalities
This study discusses disseminated intravascular coagulation (DIC) associated with solid cancers and various vascular abnor...
A cohort-based multi-omics identifies nuclear translocation of eIF5B /PD-L1/CD44 complex as the target to overcome Osimertinib resistance of ARID1A-deficient lung adenocarcinoma
A cohort-based multi-omics identifies nuclear translocation of eIF5B /PD-L1/CD44 complex as the target to overcome Osimertinib resistance of ARID1A-deficient lung adenocarcinoma
Osimertinib has emerged as a critical element in the treatment landscape following recent clinical trials. Further investi...
Liquid biopsy entering clinical practice: Past discoveries, current insights, and future innovations
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131I-mIBG therapy in relapsed/refractory neuroblastoma: A weapon from the future past
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Efficacy and safety of PARP inhibitors in prostate cancer: An umbrella review of systematic reviews and meta-analyses
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Circular RNAs as key regulators in cancer hallmarks: New progress and therapeutic opportunities
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Evaluating MicroRNAs as diagnostic tools for lymph node metastasis in breast cancer: Findings from a systematic review and meta-analysis
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Variations in iron profile among dialysis adherent chronic kidney disease patients and compare with the non-adherence chronic kidney disease patients
Variations in iron profile among dialysis adherent chronic kidney disease patients and compare with the non-adherence chronic kidney disease patients
medRxiv - The Preprint Server for Health Sciences
Role of Inflammation in the Pathogenesis of Anemia in Chronic Kidney Disease: Exploring the Impact of Inflammatory Biomarkers on Erythropoiesis and Erythropoietin Response.
Role of Inflammation in the Pathogenesis of Anemia in Chronic Kidney Disease: Exploring the Impact of Inflammatory Biomarkers on Erythropoiesis and Erythropoietin Response.
medRxiv - The Preprint Server for Health Sciences
Mutant Calreticulin in MPN: Mechanistic Insights and Therapeutic Implications
Mutant Calreticulin in MPN: Mechanistic Insights and Therapeutic Implications
More than a decade following the discovery of Calreticulin (CALR) mutations as drivers of myeloproliferative neoplasms (MP...
A case of late-onset sinusoidal obstruction syndrome diagnosed histologically before meeting diagnostic criteria
A case of late-onset sinusoidal obstruction syndrome diagnosed histologically before meeting diagnostic criteria
Sinusoidal obstruction syndrome (SOS), also known as hepatic veno-occlusive disease (VOD), is a life-threatening complicat...
AI-Powered Exploration of IGF2BP3 as a Prognostic Biomarker in Chronic Myeloid Leukemia Progression and Disease Stratification.
AI-Powered Exploration of IGF2BP3 as a Prognostic Biomarker in Chronic Myeloid Leukemia Progression and Disease Stratification.
medRxiv - The Preprint Server for Health Sciences
Navigating the Economic Burden of Multiple Myeloma: Insights into Cost-effectiveness of CAR-T and Bispecific Antibody Therapies
Navigating the Economic Burden of Multiple Myeloma: Insights into Cost-effectiveness of CAR-T and Bispecific Antibody Therapies
Multiple myeloma is a chronic malignancy and with evolving treatment options, understanding the economic burden and cost-e...
Prominent efficacy and good safety of sequential CD19 and CD22 CAR-T therapy in relapsed/refractory adult B-cell acute lymphoblastic leukemia
Prominent efficacy and good safety of sequential CD19 and CD22 CAR-T therapy in relapsed/refractory adult B-cell acute lymphoblastic leukemia
Sequential CD19 and CD22 chimeric antigen receptor (CAR)-T cell therapy offers a promising approach to antigen-loss relaps...
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