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Fluorogenic polymethine dyes by intramolecular cyclization
Fluorogenic polymethine dyes by intramolecular cyclization
KeywordsFluorogenicityCarbocyaninesPolymethine dyesTurn-on probesIntramolecular cyclizationsSelf-labeling protein tagsSmal...
Sortase-mediated labeling: Expanding frontiers in site-specific protein functionalization opens new research avenues
Sortase-mediated labeling: Expanding frontiers in site-specific protein functionalization opens new research avenues
Many modern pursuits of molecular biology and biochemistry are built on precise and selective protein labeling techniques....
Site-specific protein labeling strategies for super-resolution microscopy
Site-specific protein labeling strategies for super-resolution microscopy
KeywordsSite-specific labelingSuper-resolution microscopyPeptide-tagPeptide-PAINTUnnatural amino acidNon-canonical amino a...
Recent advances in ratiometric fluorescence imaging of enzyme activity in vivo
Recent advances in ratiometric fluorescence imaging of enzyme activity in vivo
Functional imaging of enzyme activity in living systems provides valuable insights into biological processes and disease s...
Advancing mass spectrometry–based glycoproteomic software tools for comprehensive site-specific glycoproteome analysis
Advancing mass spectrometry–based glycoproteomic software tools for comprehensive site-specific glycoproteome analysis
Protein glycosylation, as one of the most widespread and complex post-translational modifications (PTMs), plays an importa...
Lumos maxima – How robust fluorophores resist photobleaching?
Lumos maxima – How robust fluorophores resist photobleaching?
Advanced fluorescence imaging technology, jointly enabled by microscopes and cutting-edge fluorescent labels, promises to ...
D-Amino acid oxidase-derived chemogenetic oxidative stress: Unraveling the multi-omic responses to in vivo redox stress
D-Amino acid oxidase-derived chemogenetic oxidative stress: Unraveling the multi-omic responses to in vivo redox stress
The dynamic equilibrium between the generation of reactive oxygen species (ROS) and the antioxidative defense mechanisms w...
Versatile roles of cysteine persulfides in tumor biology
Versatile roles of cysteine persulfides in tumor biology
Rewiring the transsulfuration pathway is recognized as a rapid adaptive metabolic response to environmental conditions in ...
A new era of cysteine proteomics – Technological advances in thiol biology
A new era of cysteine proteomics – Technological advances in thiol biology
Protein cysteines garner interest for their distinct chemical properties, rendering them amenable to a diverse range of mo...
Biochemistry of the hypoxia-inducible factor hydroxylases
Biochemistry of the hypoxia-inducible factor hydroxylases
KeywordsHypoxia-inducible factor (HIF)HIF prolyl-hydroxylases (PHDs/EGLNs)JmjC demethylasesFactor inhibiting HIF (FIH)Aspa...
Metabolomics-guided utilization of beneficial microbes for climate-resilient crops
Metabolomics-guided utilization of beneficial microbes for climate-resilient crops
In the rhizosphere, plants and microbes communicate chemically, especially under environmental stress. Over millions of ye...
New frontiers in sulfur and selenium chemical biology
New frontiers in sulfur and selenium chemical biology
Kate S. Carroll is a Professor in the Department of Chemistry at the Herbert Werthheim UF Scripps Institute for Biomedical...
Peroxisomal hydrogen peroxide signaling: A new chapter in intracellular communication research
Peroxisomal hydrogen peroxide signaling: A new chapter in intracellular communication research
KeywordsPeroxisomesHydrogen peroxideSulfenomeThiol-based redox signalingPeroxiredoxinsRedox relayCalciumProtein phosphoryl...
Electrophilic metabolites targeting the KEAP1/NRF2 partnership
Electrophilic metabolites targeting the KEAP1/NRF2 partnership
Numerous electrophilic metabolites are formed during cellular activity, particularly under conditions of oxidative, inflam...
Recent antibacterial carbohydrate-based prodrugs, drugs and delivery systems to overcome antimicrobial resistance
Recent antibacterial carbohydrate-based prodrugs, drugs and delivery systems to overcome antimicrobial resistance
Antimicrobial resistance is an increasing phenomenon that is threatening global health. Tuberculosis causative bacteria an...
Recent progress in the synthesis of glycosphingolipids
Recent progress in the synthesis of glycosphingolipids
To accelerate the biological study and application of the diverse functions of glycosphingolipids (GSLs), the production o...
Recent advances in antibody glycoengineering for the gain of functions
Recent advances in antibody glycoengineering for the gain of functions
Glycans play important roles in antibody functions, and antibody glycoengineering has long been an important research fiel...
Recent chemical synthesis and immunological evaluation of glycans related to bacterial lipopolysaccharides
Recent chemical synthesis and immunological evaluation of glycans related to bacterial lipopolysaccharides
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Recent advances in enzymatic and chemoenzymatic synthesis of N- and O-glycans
Recent advances in enzymatic and chemoenzymatic synthesis of N- and O-glycans
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Synthesis and application of bacterial exopolysaccharides
Synthesis and application of bacterial exopolysaccharides
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Blurred lines: Crossing the boundaries between the chemical exposome and the metabolome
Blurred lines: Crossing the boundaries between the chemical exposome and the metabolome
The aetiology of every human disease lies in a combination of genetic and environmental factors, each contributing in vary...
Small-molecule tools for YEATS domain proteins
Small-molecule tools for YEATS domain proteins
Transcriptional co-regulatory proteins act on and through chromatin to control RNA polymerase activity [1]. These proteins...
Editorial overview: Glycobiology (2023)
Editorial overview: Glycobiology (2023)
Matthew Macauley is an associate professor within the Department of Chemistry at the University of Alberta and currently h...
Strategies for quantifying the enzymatic activities of glycoside hydrolases within cells and in vivo
Strategies for quantifying the enzymatic activities of glycoside hydrolases within cells and in vivo
Enzymes mediate a great diversity of reactions that enable a wide range of cellular processes. The activities of enzymes w...
Nutritional metabolomics: Recent developments and future needs
Nutritional metabolomics: Recent developments and future needs
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Metabolic interventions to enhance immunotherapy and targeted therapy efficacy in advanced colorectal cancer
Metabolic interventions to enhance immunotherapy and targeted therapy efficacy in advanced colorectal cancer
Current standard-of-care for metastatic colorectal cancer patients includes chemotherapy and anti-angiogenic or anti-epide...
Immunomodulatory roles of PARPs: Shaping the tumor microenvironment, one ADP-ribose at a time
Immunomodulatory roles of PARPs: Shaping the tumor microenvironment, one ADP-ribose at a time
PARPs encompass a small yet pervasive group of 17 enzymes that catalyze a post-translational modification known as ADP-rib...
Global approaches for protein thiol redox state detection
Global approaches for protein thiol redox state detection
Due to its nucleophilicity, the thiol group of cysteine is chemically very versatile. Hence, cysteine often has important ...