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Small-angle X-ray scattering studies of enzymes
Enzyme function requires conformational changes to achieve substrate binding, domain rearrangements, and interactions with...
Substrate-selective small-molecule modulators of enzymes: Mechanisms and opportunities
Small-molecule inhibitors of enzymes are widely used tools in reverse chemical genetics to probe biology and explore thera...
Inhibition of p53 protein aggregation as a cancer treatment strategy
The p53 protein plays a critical role in the prevention of genome mutations in the body, however, this protein is frequent...
Engineering Rieske oxygenase activity one piece at a time
Enzyme engineering plays a central role in the development of biocatalysts for biotechnology, chemical and pharmaceutical ...
Realgar and arsenene nanomaterials as arsenic-based anticancer agents
Arsenic trioxide (ATO) is an approved therapy for the treatment of acute promyelocytic leukemia, but the extension of arse...
Dynamics and mechanistic interpretations of nonribosomal peptide synthetase cyclization domains
Ox-/thiazoline groups in nonribosomal peptides are formed by a variant of peptide-forming condensation domains called hete...
Recent progress in mass spectrometry for single-cell metabolomics
Metabolites are the end products of cellular vital activities and can reflect the state of cellular to a certain extent. R...
Thermal proteome profiling: Insights into protein modifications, associations, and functions
Tracking proteins’ biophysical characteristics on a proteome-wide scale can provide valuable information on their function...
Study of spatiotemporal regulation of kinase signaling using genetically encodable molecular tools
Precise spatiotemporal organization and regulation of signal transduction networks are essential for cellular response to ...
Recent advances in the structural biology of modular polyketide synthases and nonribosomal peptide synthetases
Polyketides and nonribosomal peptides are an important class of natural products with useful bioactivities. These compound...
Emerging chemistry and biology in protein glutathionylation
Protein S-glutathionylation serves a regulatory role in proteins and modulates distinct biological processes implicated in...
Fluorescent sterol probes for intracellular transport, imaging, and therapeutics
Volume 71, December 2022, 102222AbstractSterols play a significant role in many physiological processes affecting membrane...
Convergent and divergent biosynthetic strategies towards phosphonic acid natural products
Volume 71, December 2022, 102214AbstractThe phosphonate class of natural products have received significant interests in t...
Taming glutathione potentiates metallodrug action
Volume 71, December 2022, 102213AbstractMetallodrugs that are redox sensitive or have labile coordination sites are partic...
Structures and functions of algal glycans shape their capacity to sequester carbon in the ocean
Volume 71, December 2022, 102204AbstractAlgae synthesise structurally complex glycans to build a protective barrier, the e...
Recent advances in the structural analysis of adenylation domains in natural product biosynthesis
Volume 71, December 2022, 102212Highlights•Adenylation domain is a core domain in nonribosomal peptide synthetases.•Adenyl...
In situ synthesis of artificial lipids
Volume 71, December 2022, 102210AbstractLipids constitute one of the most enigmatic family of biological molecules. Althou...
Lipid mimetics: A versatile toolbox for lipid biology and beyond
Volume 71, December 2022, 102209AbstractBeing the principal component of biological membranes lipids are essential buildin...
Insights into SACS pathological attributes in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS)☆
Volume 71, December 2022, 102211Highlights•ARSACS is an early-onset neurodegenerative disease caused by SACS loss-of-funct...
Network analysis of genome-wide association studies for drug target prioritisation
Volume 71, December 2022, 102206AbstractOver the past decades, genome-wide association studies (GWAS) have led to a dramat...
The bright frontiers of microbial metabolic optogenetics
Volume 71, December 2022, 102207AbstractIn recent years, light-responsive systems from the field of optogenetics have been...
Synthetic fragments of plant polysaccharides as tools for cell wall biology
Volume 71, December 2022, 102208AbstractA sustainable bioeconomy that includes increased agricultural productivity and new...
Mechanism and inhibition of BRAF kinase
Volume 71, December 2022, 102205AbstractThe role of BRAF in tumor initiation has been established, however, the precise me...
Fluorescent indicators for imaging membrane potential of organelles
Volume 71, December 2022, 102203AbstractPlasma membrane potential is a key driver of the physiology of excitable cells lik...
Recent advances on human milk oligosaccharide antimicrobial activity
Volume 71, December 2022, 102202AbstractOver the past century, human health has been enhanced by antimicrobial development...
Promoting remyelination: A case study in regenerative medicine
Volume 70, October 2022, 102201Highlights•Remyelination is a spontaneous regenerative response to demyelination.•New oligo...
Molecular network strategy in multi-omics and mass spectrometry imaging
Volume 70, October 2022, 102199Highlights•Network analysis is an approach for acquiring feature and interaction of molecul...
Shedding light on current trends in molecular optogenetics
Volume 70, October 2022, 102196AbstractMolecular optogenetics is a highly dynamic research field. In the past two years, t...
Recent advances in polysaccharide-based in situ forming hydrogels
Volume 70, October 2022, 102200AbstractPolysaccharides comprise an important class of natural polymers; they are abundant,...
Engineered living materials (ELMs) design: From function allocation to dynamic behavior modulation
Volume 70, October 2022, 102188Highlights•Introduction of endogenous or exogenous functional modules endows ELMs with emer...