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Emerging mechanisms of regulation for endoplasmic/sarcoplasmic reticulum Ca2+ stores by secretory pathway kinase FAM20C
Eukaryotes depend upon the proper localization, accumulation, and release of intracellular Ca2+. This is regulated through...
Recent advances in mass spectrometry-based computational metabolomics
KeywordsMetabolomicsMulti-omicsMachine learningMetabolite identificationCheminformaticsChemometricsVisualizationBenchmarki...
The chemical basis of cytotoxicity of silicon-phthalocyanine-based near infrared photoimmunotherapy (NIR-PIT) and its implications for treatment monitoring
Near infrared photoimmunotherapy (NIR-PIT) is a new cancer therapy based on the photo-induced ligand release reaction of a...
Chemical tools targeting readers of lysine methylation
KeywordsReader domainsChemical probesPost-translational modificationsLysine methylationPeptidomimetic ligandsSmall-molecul...
Metabolomic profiling reveals bacterial metabolic adaptation strategies and new metabolites
How has metabolomics helped our understanding of infectious diseases? With the threat of antimicrobial resistance to human...
Glycosidase mechanisms: Sugar conformations and reactivity in endo- and exo-acting enzymes
KeywordsGlycosidasesCarbohydratesSugar conformationsMolecular dynamicsQuantum mechanics/molecular mechanicsMetadynamicsDen...
Genetically encoded fluorescent sensors for metals in biology
Metal ions intersect a wide range of biological processes. Some metal ions are essential and hence absolutely required for...
Anti-glycan monoclonal antibodies: Basic research and clinical applications
Anti-glycan monoclonal antibodies have important applications in human health and basic research. Therapeutic antibodies t...
Residue selective crosslinking of proteins through photoactivatable or proximity-enabled reactivity
KeywordsPhoto-crosslinkingChemical crosslinkingChemical crosslinking mass spectrometryGenetic code expansionProximity-enab...
Editorial: Mechanistic biology
Philip Cole graduated from Yale College then spent 1 year as a Churchill Scholar at Cambridge before receiving MD and PhD ...
Structural biology of proteins involved in nitrogen cycling
Microbial metabolic processes drive the global nitrogen cycle through sophisticated and often unique metalloenzymes that f...
Supramolecular platinum complexes for cancer therapy
The rise of supramolecular chemistry offers new tools to design therapeutics and delivery platforms for biomedical applica...
Role of conformational dynamics in pathogenic protein aggregation
KeywordsAmyloid diseaseOligomeric intermediatesBiophysical characterizationTransthyretinAbetaHuntingtinAlpha-synucleinAβα-...
Immunogenic cell death-inducing metal complexes: From the benchtop to the clinic
The immune system presents a complex array of processes designed to maintain homeostasis in malignant cellular growth. Mal...
Tuning specificity and topology of lectins through synthetic biology
Lectins are non-immunoglobulin and non-catalytic glycan binding proteins that are able to decipher the structure and funct...
Editorial overview: Synthetic biomolecules for probing lipid membranes
Shinya Tsukiji is a professor in the Department of Life Science and Applied Chemistry and the Department of Nanopharmaceut...
Critical considerations in N-glycoproteomics
N-Glycoproteomics, the system-wide study of glycans asparagine-linked to protein carriers, holds a unique and still largel...
Recent advances on the synthesis of N-linked glycoprotein for the elucidation of glycan functions
Glycoproteins play roles in many biological events, while, the glycan structure-function relationship has remained to be s...
Chemo- and opto-genetic tools for dissecting the role of membrane contact sites in living cells: Recent advances and limitations
Membrane contact sites (MCSs) are morphologically defined intracellular structures where cellular membranes are closely ap...
Multi-omics approaches to study platelet mechanisms
Platelets are small anucleate cell fragments (2–4 μm in diameter) in the blood, which play an essential role in thrombosis...
Diverse strategies adopted by nature for regulating purine biosynthesis via fine-tuning of purine metabolic enzymes
Purine nucleotides, generated by de novo synthesis and salvage pathways, are essential for metabolism and act as building ...
Recent advances in kinase signaling network profiling by mass spectrometry
Mass spectrometry-based phosphoproteomics is currently the leading methodology for the study of global kinase signaling. T...
Identification and quantification of DNA N6-methyladenine modification in mammals: A challenge to modern analytical technologies
DNA N6-methyladenine modification (6mA) is a predominant epigenetic mark in prokaryotes but rarely present in multicellula...
Editorial overview - Exploring the diversity of polysaccharides
Martina Delbianco obtained her PhD from Durham University (UK) under the supervision of Prof. David Parker. She then moved...
The Ramifications of synthetic biology
Wilfried Weber is Professor of Synthetic Biology. His research is positioned at the intersection of synthetic biology and ...
Expanding the viewpoint: Leveraging sequence information in enzymology
KeywordsGenomic enzymologySequence similarity networkEnzyme evolutionGenome neighborhoodMetabolic pathwaysAbbreviationsddh...
Methods to identify protein targets of metal-based drugs
Metal-based anticancer agents occupy a distinct chemical space due to their particular coordination geometry and reactivit...
KATs off: Biomedical insights from lysine acetyltransferase inhibitors
Lysine acetyltransferase (KAT) enzymes including the p300, MYST, and GCN5 families play major roles in modulating the stru...
Lipidomics analysis in drug discovery and development
Despite being a relatively new addition to the Omics' landscape, lipidomics is increasingly being recognized as an importa...
Editorial overview: Modality, discovery, and class
Luke Lairson is an Associate Professor in the Department of Chemistry at Scripps Research (La Jolla, CA). He obtained his ...
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