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Recent chemical synthesis of plant polysaccharides
Recent chemical synthesis of plant polysaccharides
As the essential and most abundant biomolecules, carbohydrates are involved in the numerous biological processes with a va...
Navigating the terrain of protein aggregation and phase separation - A chemical biology perspective
Navigating the terrain of protein aggregation and phase separation - A chemical biology perspective
Cong Liu received his Ph.D. in Biochemistry from the Peking University, followed by a postdoc training at UCLA. He started...
Recent advances in Zn2+ imaging: From organelles to in vivo applications
Recent advances in Zn2+ imaging: From organelles to in vivo applications
Zinc (Zn2+) is an important component of various proteins and plays important roles in many biological processes. It is bu...
A translational blueprint for developing intraoperative imaging agents via radiopharmaceutical-guided drug design
A translational blueprint for developing intraoperative imaging agents via radiopharmaceutical-guided drug design
Curative oncologic surgery successfully removes all cancerous tissues from the body and is the most effective treatment mo...
Virus-assisted directed evolution of biomolecules
Billions of years of natural evolution has created an astounding variety of biomolecules with diverse structures and funct...
Advanced imaging techniques for studying protein phase separation in living cells and at single-molecule level
Proteins and nucleic acids undergo countless encounters in the cell. While some interactions exhibit well-defined stoichio...
Luminescent lanthanide probes for cations and anions: Promises, compromises, and caveats
Luminescent lanthanide probes, including those emitting in the visible (EuIII, TbIII, DyIII, and SmIII) and the infrared r...
Peptide-based molecules for the disruption of bacterial Hsp70 chaperones
The heat shock protein 70 (Hsp70) family aids in the maintenance of protein homeostasis, or proteostasis, across species. ...
Multimodal and multiscale correlative elemental imaging: From whole tissues down to organelles
‘Nature loves to hide’. These elegant words, written by Heraclitus of Ephesus about 2500 years ago, can be interpreted in ...
The redox riddle of selenium sulfide
There are quite a few movies which besides being highly entertaining also touch on real science. Apart from classics such ...
The influence of alkylating agents on sulfur–sulfur bonds in per- and polysulfides
Per- and polysulfides are sulfane sulfur species produced inside living cells, in organisms as diverse as bacteria, plants...
Highlights of bioinformatic tools and methods for validating bioinformatics derived hypotheses for microbial natural products research
Natural products (NPs) encompass various bioactive compounds originating from secondary metabolism in diverse organisms [1...
Recent advances towards mass spectrometry-based clinical lipidomics
The objective of this review is to provide a comprehensive summary of the latest methodological advancements and emerging ...
Characteristics of genetic tags for correlative light and electron microscopy
There are many genetic tags available for fluorescence microscopy (FM), enabling proteins to be labeled with fluorescent r...
Improving precision surgery: A review of current intraoperative nerve tissue fluorescence imaging
Iatrogenic nerve injury represents one of the most feared surgical complications and remains a major morbidity across many...
The many facets of sulfur incorporation in natural product biosynthesis
Sulfur-containing natural products (S-containing NPs) encompass virtually every class of NP discovered to date. Nature has...
The role of metals in the next generation of anticancer therapeutics
Justin Wilson is an associate professor of chemistry and chemical biology at Cornell University. His research program focu...
Analytical techniques in chemical biology
RuijunTianis a Professor in the Department of Chemistry, Southern University of Science and Technology (SUSTech). He recei...
Activity-based protein profiling in microbes and the gut microbiome
Bacteria are the most abundant microorganisms on our planet, existing ubiquitously in the environment and colonizing numer...
Spatial metabolomics principles and application to cancer research
Metabolic rewiring is an important modulator of cancer progression [1,2], which may contribute to treatment resistance [3]...
Activity-based probes in pathogenic bacteria: Investigating drug targets and molecule specificity
It is well known that bacterial infections are a significant risk to global public health. This is grossly exacerbated by ...
New advances in cross-linking mass spectrometry toward structural systems biology
Protein–protein interactions (PPIs) are central to the structure and function of protein complexes. These modular assembli...
Sensing and regulation of reactive sulfur species (RSS) in bacteria
The innate immune system of the vertebrate host has many antibacterial weapons in a comprehensive arsenal of strategies de...
How do metabolic processes age: Evidence from human metabolomic studies
Metabolomics, the global profiling of small molecules in the body, has emerged as a promising analytical approach for asse...
The multifaceted nature of peroxiredoxins in chemical biology
Peroxiredoxins (Prx) are a family of peroxidases that reduce the peroxide substrate at the expense of a particular cystein...
Recent advances in developing degraders & inhibitors of lysine methyltransferases
Epigenetic regulation plays a crucial role in human diseases such as cancer, inspiring a generation of novel therapeutic i...
Emergence of (hydro)persulfides as suppressors of lipid peroxidation and ferroptotic cell death
Since the turn of the millennium, hydrogen sulfide (H2S) has become recognized as one of the key “gasotransmitters”—alongs...
Small molecule fluorescent probes for the study of protein phase separation
Cells consist of a complex mixture of biomolecules. Precise regulation of spatial and temporal distribution for these biom...
Chemical biology approaches to uncovering nuclear ROS control
Metabolic compartmentalization is an essential feature of eukaryotic cells, providing a mechanism for resource allocation,...
Cysteine and methionine oxidation in thrombotic disorders
Oxidative stress is characteristic of many systemic and metabolic disorders. Oxidants generated during oxidative stress pr...
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