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MPC-n (IgG) improves long-term cognitive impairment in the mouse model of repetitive mild traumatic brain injury
Contact sports athletes and military personnel who suffered a repetitive mild traumatic brain injury (rmTBI) are at high r...
Multimodal-based machine learning strategy for accurate and non-invasive prediction of intramedullary glioma grade and mutation status of molecular markers: a retrospective study
Determining the grade and molecular marker status of intramedullary gliomas is important for assessing treatment outcomes ...
Adipsin alleviates cardiac microvascular injury in diabetic cardiomyopathy through Csk-dependent signaling mechanism
Microvascular complications are associated with an overtly increased risk of adverse outcomes in patients with diabetes in...
Cancer risk following surgical removal of tonsils and adenoids — a population-based, sibling-controlled cohort study in Sweden
Removal of tonsils and adenoids is among the most common surgical procedures worldwide. Evidence of increased risk of canc...
A combination of genetically engineered oncolytic virus and melittin-CpG for cancer viro-chemo-immunotherapy
Immunotherapy has emerged as an efficient therapeutic approach for cancer management. However, stimulation of host immune ...
The effect of dietary carbohydrate and calorie restriction on weight and metabolic health in overweight/obese individuals: a multi-center randomized controlled trial
Both low‐carbohydrate (LC) and calorie-restricted (CR) diets have been shown to have metabolic benefits. However, th...
Effects of ketogenic diet on health outcomes: an umbrella review of meta-analyses of randomized clinical trials
Systematic reviews and meta-analyses of randomized clinical trials (RCTs) have reported the benefits of ketogenic diets (K...
The effects of coagulation factors on the risk of endometriosis: a Mendelian randomization study
Endometriosis is recognized as a complex gynecological disorder that can cause severe pain and infertility, affecting 6...
Putting Chagas disease on the global health agenda
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Autophagy-related genes analysis reveals potential biomarkers for prediction of the impaired walking capacity of peripheral arterial disease
The role of autophagy and autophagy-related genes in peripheral arterial disease (PAD) remains unknown and may be of diagn...
Standardizing the reporting of Mendelian randomization studies
Reporting of MR studies has been variable, hence limiting potential for appraisal . Consequently, the STROBE-MR checkli...
The impact of non-alcoholic fatty liver disease and liver fibrosis on adverse clinical outcomes and mortality in patients with chronic kidney disease: a prospective cohort study using the UK Biobank
Chronic kidney disease (CKD) and non-alcoholic fatty liver disease (NAFLD) frequently co-exist. We assess the impact of ha...
Statistical analysis of high-dimensional biomedical data: a gentle introduction to analytical goals, common approaches and challenges
In high-dimensional data (HDD) settings, the number of variables associated with each observation is very large. Prominent...
New respiratory syncytial virus immunization products in low- and middle-income countries: potential for cost-effective impact on a high burden of disease in young infants
As new, efficacious respiratory syncytial virus (RSV) immunization products reach the market, affordable pricing as well a...
Increasing emergency number utilisation is not driven by low-acuity calls: an observational study of 1.5 million emergency calls (2018–2021) from Berlin
The Emergency Medical Service (EMS) in Germany is increasingly challenged by strongly rising demand. Speculations about a ...
Unexpectedly higher levels of anti-orthopoxvirus neutralizing antibodies are observed among gay men than general adult population
The confirmed cases in the current outbreak of Monkeypox are predominantly identified in the networks of men who have sex ...
Saving time and money in biomedical publishing: the case for free-format submissions with minimal requirements
Manuscript preparation and the (re)submission of articles can create a significant workload in academic jobs. In this expl...
Oxidative stress gene expression, DNA methylation, and gut microbiota interaction trigger Crohn’s disease: a multi-omics Mendelian randomization study
Oxidative stress (OS) is a key pathophysiological mechanism in Crohn’s disease (CD). OS-related genes can be affecte...
Chemotherapy-induced weight gain in early-stage breast cancer: a prospective matched cohort study reveals associations with inflammation and gut dysbiosis
Early-stage breast cancer patients treated with chemotherapy risk the development of metabolic disease and weight gain, wh...
Change in habitual intakes of flavonoid-rich foods and mortality in US males and females
Higher baseline intakes of flavonoid-rich foods and beverages are associated with a lower risk of chronic disease and mort...
Accuracy of minimal residual disease detection by circulating tumor DNA profiling in lung cancer: a meta-analysis
The sensitivity and specificity of minimal residual disease detected by circulating tumor DNA profiling (ctDNA MRD) in lun...
Safety and efficacy of apatinib in patients with advanced gastric or gastroesophageal junction adenocarcinoma after the failure of two or more lines of chemotherapy (AHEAD): a prospective, single-arm, multicenter, phase IV study
Apatinib, a highly selective VEGFR2 inhibitor, significantly improved efficacy versus placebo as a third- and later-line t...
Gut taste receptor type 1 member 3 is an intrinsic regulator of Western diet-induced intestinal inflammation
Long-term intake of a Western diet (WD), characterized by a high-fat content and sugary drinks, is hypothesized to contrib...
Single-cell sequencing reveals the immune microenvironment landscape related to anti-PD-1 resistance in metastatic colorectal cancer with high microsatellite instability
The objective response rate of microsatellite instability-high (MSI-H) metastatic colorectal cancer (mCRC) patients with f...
Real-world effectiveness and factors associated with effectiveness of inactivated SARS-CoV-2 vaccines: a systematic review and meta-regression analysis
The two inactivated SARS-CoV-2 vaccines, CoronaVac and BBIBP-CorV, have been widely used to control the COVID-19 pandemic....
Central nervous system efficacy of furmonertinib (AST2818) in patients with EGFR T790M mutated non-small cell lung cancer: a pooled analysis from two phase 2 studies
Furmonertinib (AST2818) is a brain penetrant pan-epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) t...
Impact of oral intervention on the oral and overall health of children living with HIV in Cambodia: a randomized controlled trial
Maintaining oral health is essential for improving overall health of children living with HIV. Therefore, we evaluated the...
Cross-talks between gut microbiota and tobacco smoking: a two-sample Mendelian randomization study
Considerable evidence has been reported that tobacco use could cause alterations in gut microbiota composition. The microb...
MECP2 germline mosaicism plays an important part in the inheritance of Rett syndrome: a study of MECP2 germline mosaicism in males
Germline mosaicisms could be inherited to offspring, which considered as “de novo” in most cases. Paternal ger...
Three tyrosine kinase inhibitors cause cardiotoxicity by inducing endoplasmic reticulum stress and inflammation in cardiomyocytes
Tyrosine kinase inhibitors (TKIs) are anti-cancer therapeutics often prescribed for long-term treatment. Many of these tre...
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