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Is trofinetide a future treatment for Rett syndrome? A comprehensive systematic review and meta-analysis of randomized controlled trials
Is trofinetide a future treatment for Rett syndrome? A comprehensive systematic review and meta-analysis of randomized controlled trials
Rett syndrome (RTT) is a rare, life-threatening, genetic neurodevelopmental disorder. Treatment in RTT encounters many cha...
Estimating the relative importance of epidemiological and behavioural parameters for epidemic mpox transmission: a modelling study
Estimating the relative importance of epidemiological and behavioural parameters for epidemic mpox transmission: a modelling study
Many European countries experienced outbreaks of mpox in 2022, and there was an mpox outbreak in 2023 in the Democratic Re...
Gut microbiome in endometriosis: a cohort study on 1000 individuals
Gut microbiome in endometriosis: a cohort study on 1000 individuals
Endometriosis, defined as the presence of endometrial-like tissue outside of the uterus, is one of the most prevalent gyne...
Comparative analysis of atherosclerotic cardiovascular disease burden between ages 20–54 and over 55 years: insights from the Global Burden of Disease Study 2019
Comparative analysis of atherosclerotic cardiovascular disease burden between ages 20–54 and over 55 years: insights from the Global Burden of Disease Study 2019
To systematically analyze differences in atherosclerotic cardiovascular disease (ASCVD) burden between young and older adu...
The clinical value of artificial intelligence in assisting junior radiologists in thyroid ultrasound: a multicenter prospective study from real clinical practice
The clinical value of artificial intelligence in assisting junior radiologists in thyroid ultrasound: a multicenter prospective study from real clinical practice
This study is to propose a clinically applicable 2-echelon (2e) diagnostic criteria for the analysis of thyroid nodules su...
Multimodal neuroimaging exploration of the mechanisms of sleep quality deterioration after SARS-CoV-2 Omicron infection
Multimodal neuroimaging exploration of the mechanisms of sleep quality deterioration after SARS-CoV-2 Omicron infection
To evaluate the neurological alterations induced by Omicron infection, to compare brain changes in chronic insomnia with t...
Metformin use correlated with lower risk of cardiometabolic diseases and related mortality among US cancer survivors: evidence from a nationally representative cohort study
Metformin use correlated with lower risk of cardiometabolic diseases and related mortality among US cancer survivors: evidence from a nationally representative cohort study
In the USA, the prolonged effective survival of cancer population has brought significant attention to the rising risk of ...
Temporal trends in population attributable fractions of modifiable risk factors for dementia: a time-series study of the English Longitudinal Study of Ageing (2004–2019)
Temporal trends in population attributable fractions of modifiable risk factors for dementia: a time-series study of the English Longitudinal Study of Ageing (2004–2019)
Interest in modifiable risk factors (MRFs) for dementia is high, given the personal, social, and economic impact of the di...
Assessing the efficiency of eligibility criteria for low-dose computed tomography lung screening in China according to current guidelines
Assessing the efficiency of eligibility criteria for low-dose computed tomography lung screening in China according to current guidelines
Evidence from observational studies indicates that lung cancer screening (LCS) guidelines with high rates of lung cancer (...
Effects of non-pharmacological interventions for adults with subjective cognitive decline: a network meta-analysis and component network meta-analysis
Effects of non-pharmacological interventions for adults with subjective cognitive decline: a network meta-analysis and component network meta-analysis
Non-pharmacological interventions have a myriad of available intervention options and contain multiple components. Whether...
Long-term health outcomes by cancer diagnosed age among adolescent and young adult: multinational representative database
Long-term health outcomes by cancer diagnosed age among adolescent and young adult: multinational representative database
The cancer experienced in adolescent and young adult (AYA) could disturb developmental changes and long-term life. The cur...
Impact of baseline cardiovascular risk on the outcomes of intensive blood pressure intervention: a post hoc analysis of the China rural hypertension control project
Impact of baseline cardiovascular risk on the outcomes of intensive blood pressure intervention: a post hoc analysis of the China rural hypertension control project
The 2018/2023 ESC/ESH Guidelines underlined a gap how baseline cardiovascular disease (CVD) risk predicted blood pressure ...
EEG signatures of cognitive decline after mild SARS-CoV-2 infection: an age-dependent study
EEG signatures of cognitive decline after mild SARS-CoV-2 infection: an age-dependent study
Current research on the neurological impact of SARS-CoV-2 primarily focuses on the elderly or severely ill individuals. Th...
Circulating small extracellular vesicles in Alzheimer’s disease: a case–control study of neuro-inflammation and synaptic dysfunction
Circulating small extracellular vesicles in Alzheimer’s disease: a case–control study of neuro-inflammation and synaptic dysfunction
Alzheimer’s disease (AD) is a neurodegenerative disease characterized by Aβ plaques and neurofibrillary tangles...
Cognitive enhancing effect of rTMS combined with tDCS in patients with major depressive disorder: a double-blind, randomized, sham-controlled study
Cognitive enhancing effect of rTMS combined with tDCS in patients with major depressive disorder: a double-blind, randomized, sham-controlled study
Cognitive dysfunction is one of the common symptoms in patients with major depressive disorder (MDD). Repetitive transcran...
First-in-human, double-blind, randomized phase 1b study of peptide immunotherapy IMCY-0098 in new-onset type 1 diabetes: an exploratory analysis of immune biomarkers
First-in-human, double-blind, randomized phase 1b study of peptide immunotherapy IMCY-0098 in new-onset type 1 diabetes: an exploratory analysis of immune biomarkers
IMCY-0098, a synthetic peptide developed to halt disease progression via elimination of key immune cells in the autoimmune...
Taxane combined with lobaplatin or anthracycline for neoadjuvant chemotherapy of triple-negative breast cancer: a randomized, controlled, phase II study
Taxane combined with lobaplatin or anthracycline for neoadjuvant chemotherapy of triple-negative breast cancer: a randomized, controlled, phase II study
Previous studies have shown that the addition of platinum to neoadjuvant chemotherapy (NAC) improved outcomes for patients...
Perceived barriers and facilitators for model-informed dosing in pregnancy: a qualitative study across healthcare practitioners and pregnant women
Perceived barriers and facilitators for model-informed dosing in pregnancy: a qualitative study across healthcare practitioners and pregnant women
Most women use medication during pregnancy. Pregnancy-induced changes in physiology may require antenatal dose alterations...
Distance-related functional reorganization predicts motor outcome in stroke patients
Distance-related functional reorganization predicts motor outcome in stroke patients
Analyzing distance-dependent functional connectivity density (FCD) yields valuable insights into patterns of brain activit...
“The dream is that there’s one place you go”: a qualitative study of women’s experiences seeking care from Long COVID clinics in the USA
“The dream is that there’s one place you go”: a qualitative study of women’s experiences seeking care from Long COVID clinics in the USA
Seeking and obtaining effective health care for Long COVID remains a challenge in the USA. Women have particularly been im...
Minimally invasive surgeries for spontaneous hypertensive intracerebral hemorrhage (MISICH): a multicenter randomized controlled trial
Minimally invasive surgeries for spontaneous hypertensive intracerebral hemorrhage (MISICH): a multicenter randomized controlled trial
Intracerebral hemorrhage (ICH) is a common stroke type with high morbidity and mortality. There are mainly three surgical ...
Endothelial dysfunction and persistent inflammation in severe post-COVID-19 patients: implications for gas exchange
Endothelial dysfunction and persistent inflammation in severe post-COVID-19 patients: implications for gas exchange
Understanding the enduring respiratory consequences of severe COVID-19 is crucial for comprehensive patient care. This stu...
Effectiveness of home treatment in children and adolescents with psychiatric disorders—systematic review and meta-analysis
Effectiveness of home treatment in children and adolescents with psychiatric disorders—systematic review and meta-analysis
Home treatment in child and adolescent psychiatry offers an alternative to conventional inpatient treatment by involving t...
Utility of shaking chills as a diagnostic sign for bacteremia in adults: a systematic review and meta-analysis
Utility of shaking chills as a diagnostic sign for bacteremia in adults: a systematic review and meta-analysis
Accurate prediction of bacteremia is essential for guiding blood culture collection and optimal antibiotic treatment. Shak...
Uptake, effectiveness and safety of COVID-19 vaccines in individuals at clinical risk due to immunosuppressive drug therapy or transplantation procedures: a population-based cohort study in England
Uptake, effectiveness and safety of COVID-19 vaccines in individuals at clinical risk due to immunosuppressive drug therapy or transplantation procedures: a population-based cohort study in England
Immunocompromised individuals are at increased risk of severe COVID-19 outcomes, underscoring the importance of COVID-19 v...
Validation of the Health Assessment Tool (HAT) based on four aging cohorts from the Swedish National study on Aging and Care
Validation of the Health Assessment Tool (HAT) based on four aging cohorts from the Swedish National study on Aging and Care
As global aging accelerates, routinely assessing the functional status and morbidity burden of older patients becomes para...
Examining the impact of substance use on hospital length of stay in schizophrenia spectrum disorder: a retrospective analysis
Examining the impact of substance use on hospital length of stay in schizophrenia spectrum disorder: a retrospective analysis
Among patients diagnosed with schizophrenia, the presence of substance use poses an aggravating comorbidity, exerting a ne...
How effective is the BNT162b2 mRNA vaccine against SARS-CoV-2 transmission and infection? A national programme analysis in Monaco, July 2021 to September 2022
How effective is the BNT162b2 mRNA vaccine against SARS-CoV-2 transmission and infection? A national programme analysis in Monaco, July 2021 to September 2022
We quantified SARS-CoV-2 dynamics in different community settings and the direct and indirect effect of the BNT162b2 mRNA ...
Association of depressive symptoms and sleep disturbances with survival among US adult cancer survivors
Association of depressive symptoms and sleep disturbances with survival among US adult cancer survivors
Depression and sleep disturbances are associated with increased risks of various diseases and mortality, but their impacts...
Sex-specific associations of adolescent motherhood with cognitive function, behavioral problems, and autistic-like traits in offspring and the mediating roles of family conflict and altered brain structure
Sex-specific associations of adolescent motherhood with cognitive function, behavioral problems, and autistic-like traits in offspring and the mediating roles of family conflict and altered brain structure
Previous studies have linked adolescent motherhood to adverse neurodevelopmental outcomes in offspring, yet the sex-specif...
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