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A digital application and augmented physician rounds reduce postoperative pain and opioid consumption after primary total knee replacement (TKR): a randomized clinical trial
Severe postoperative pain not only is a considerable burden for patients but also leads to overprescription of opioids, re...
Short stature and language development in the United Kingdom: a longitudinal analysis of children from the Millennium Cohort Study
In low- and middle-income countries, poverty and impaired growth prevent children from meeting their cognitive development...
Spatiotemporal trends and ecological determinants of cardiovascular mortality among 2844 counties in mainland China, 2006–2020: a Bayesian modeling study of national mortality registries
Cardiovascular disease (CVD) is the leading cause of death in China. No previous study has reported CVD mortality at count...
Retinal age gap as a predictive biomarker of stroke risk
The aim of this study is to investigate the association of retinal age gap with the risk of incident stroke and its predic...
Bidirectional genetic overlap between bipolar disorder and intelligence
Bipolar disorder (BD) is a highly heritable psychiatric illness exhibiting substantial correlation with intelligence. To i...
Predictive model for long COVID in children 3 months after a SARS-CoV-2 PCR test
To update and internally validate a model to predict children and young people (CYP) most likely to experience long COVID ...
A genome-wide association study identifies a novel association between SDC3 and apparent treatment-resistant hypertension
Compared with patients who require fewer antihypertensive agents, those with apparent treatment-resistant hypertension (aT...
Interim analysis from a phase 2 randomized trial of EuCorVac-19: a recombinant protein SARS-CoV-2 RBD nanoliposome vaccine
Numerous vaccine strategies are being advanced to control SARS-CoV-2, the cause of the COVID-19 pandemic. EuCorVac-19 (ECV...
Identifying susceptibility of children and adolescents to the Omicron variant (B.1.1.529)
The Omicron variant (B.1.1.529) is estimated to be more transmissible than previous strains of SARS-CoV-2 especially among...
Risk factors affecting COVID-19 vaccine effectiveness identified from 290 cross-country observational studies until February 2022: a meta-analysis and meta-regression
Observational studies made it possible to assess the impact of risk factors on the long-term effectiveness of mRNA and ade...
Implementation and delivery of group consultations for young people with diabetes in socioeconomically deprived, ethnically diverse settings
Young people with diabetes experience poor clinical and psychosocial outcomes, and consider the health service ill-equippe...
Prevalence and trend of smokeless tobacco use and its associated factors among adolescents aged 12–16 years in 138 countries/territories, 1999–2019
Smokeless tobacco use is popular in some regions worldwide, but it receives less attention compared to cigarette smoking. ...
Noninvasive detection of pancreatic ductal adenocarcinoma using the methylation signature of circulating tumour DNA
Pancreatic ductal adenocarcinoma (PDAC) has the lowest overall survival rate primarily due to the late onset of symptoms a...
Prognostic models for COVID-19 needed updating to warrant transportability over time and space
Supporting decisions for patients who present to the emergency department (ED) with COVID-19 requires accurate prognostica...
Economic evaluation of COVID-19 rapid antigen screening programs in the workplace
Diagnostic testing has been pivotal in detecting SARS-CoV-2 infections and reducing transmission through the isolation of ...
Longitudinal risk of maternal hospitalization for mental illness following preterm birth
Preterm birth may affect maternal mental health, yet most studies focus on postpartum mental disorders only. We explored t...
Longitudinal evolution of motor and non-motor symptoms in early-stage multiple system atrophy: a 2-year prospective cohort study
The progression of motor and non-motor symptoms (NMS) and the sensitivity of each item of the Unified Multiple System Atro...
Consumption of coffee and tea with all-cause and cause-specific mortality: a prospective cohort study
Previous studies suggested that moderate coffee and tea consumption are associated with lower risk of mortality. However, ...
Impact of parasite genomic dynamics on the sensitivity of Plasmodium falciparum isolates to piperaquine and other antimalarial drugs
Dihydroartemisinin-piperaquine (DHA-PPQ) is an alternative first-line antimalarial to artemether-lumefantrine in Kenya. Ho...
Risk for newly diagnosed diabetes after COVID-19: a systematic review and meta-analysis
There is growing evidence that patients recovering after a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in...
Association between gut microbiota and preeclampsia-eclampsia: a two-sample Mendelian randomization study
Several recent observational studies have reported that gut microbiota composition is associated with preeclampsia. Howeve...
Assessing the feasibility of sustaining SARS-CoV-2 local containment in China in the era of highly transmissible variants
The SARS-CoV-2 containment strategy has been successful in mainland China prior to the emergence of Omicron. However, in t...
Prednisolone does not improve olfactory function after COVID-19: a randomized, double-blind, placebo-controlled trial
Prednisolone has been suggested as a treatment for olfactory disorders after COVID-19, but evidence is scarce. Hence, we a...
Optimal target of LDL cholesterol level for statin treatment: challenges to monotonic relationship with cardiovascular events
Aggressive lipid lowering by high-dose statin treatment has been established for the secondary prevention of coronary arte...
Inequalities in the impact of COVID-19-associated disruptions on tuberculosis diagnosis by age and sex in 45 high TB burden countries
Tuberculosis remains a major public health priority and is the second leading cause of mortality from infectious disease w...
Dynamic monitoring of cerebrospinal fluid circulating tumor DNA to identify unique genetic profiles of brain metastatic tumors and better predict intracranial tumor responses in non-small cell lung cancer patients with brain metastases: a prospective cohort study (GASTO 1028)
Due to the blood-brain barrier, plasma is not an ideal source to evaluate the genetic characteristics of central nervous s...
Gravidity and malaria trends interact to modify P. falciparum densities and detectability in pregnancy: a 3-year prospective multi-site observational study
Low-density Plasmodium falciparum infections prevail in low transmission settings, where immunity is expected to be minima...
Intestinal gluconeogenesis is downregulated in pediatric patients with celiac disease
Untreated celiac disease (CD) patients have increased levels of blood glutamine and a lower duodenal expression of glutami...
Turning the tide towards cardiovascular prevention
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whic...
Proguanil and atovaquone use is associated with lower colorectal cancer risk: a nationwide cohort study
Individuals with a family history of colorectal cancer (CRC) are at a high risk of developing CRC. Preclinical studies sug...
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