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Clinical manifestations associated with the domain-containing protein 2 (DDHD2) gene mutation in an Iranian family with Spastic Paraplegia 54
Clinical manifestations associated with the domain-containing protein 2 (DDHD2) gene mutation in an Iranian family with Spastic Paraplegia 54
Introduction: Spastic paraplegia type 54 (SPG54) is an autosomal recessive disorder, caused by bi-allelic mutations in the...
Age of Onset and Length of Survival of Queensland Patients with Amyotrophic Lateral Sclerosis: Details of Subjects with Early Onset and Subjects with Long Survival
Age of Onset and Length of Survival of Queensland Patients with Amyotrophic Lateral Sclerosis: Details of Subjects with Early Onset and Subjects with Long Survival
<b><i>Introduction:</i></b> The aims of the study were to document the characteristics of amyotrop...
Age of onset and length of survival of Queensland patients with amyotrophic lateral sclerosis: with details of subjects with early onset and subjects with long survival.
Age of onset and length of survival of Queensland patients with amyotrophic lateral sclerosis: with details of subjects with early onset and subjects with long survival.
Introduction: To document the characteristics of ALS patients in Queensland, to examine factors influencing age of onset a...
The Immunomodulatory Potential Role of Mesenchymal Stem Cells in Diseases of the Central Nervous System
The Immunomodulatory Potential Role of Mesenchymal Stem Cells in Diseases of the Central Nervous System
Introduction: Several studies indicate the role of mesenchymal stem cells (MSCs) as an important tool in regenerative medi...
Natural age-related slow-wave sleep alterations onset prematurely in the Tg2576 mouse model of Alzheimer’s disease
Natural age-related slow-wave sleep alterations onset prematurely in the Tg2576 mouse model of Alzheimer’s disease
Introduction: Sleep insufficiency or decreased quality have been associated with Alzheimer’s disease (AD) already in its p...
CSF Aβ40 and P-Tau181 Might Differentiate Atypical from Typical AD Phenotypes: Preliminary Evidence
CSF Aβ40 and P-Tau181 Might Differentiate Atypical from Typical AD Phenotypes: Preliminary Evidence
<b><i>Objectives:</i></b> This study aimed at testing whether CSF levels of amyloid β42 (Aβ42), Aβ...
Clinical and Molecular Findings of Intermediate Allele Carriers in the HTT Gene from the Mexican Mestizo Population
Clinical and Molecular Findings of Intermediate Allele Carriers in the HTT Gene from the Mexican Mestizo Population
<b><i>Introduction:</i></b> There are reports of different clinical statuses in carriers of interm...
CSF Aβ40 and P-tau181 might differentiate atypical from typical AD phenotypes: preliminary evidence
CSF Aβ40 and P-tau181 might differentiate atypical from typical AD phenotypes: preliminary evidence
Objectives. This study aimed at testing whether CSF levels of amyloid β42 (Aβ42), Aβ40, total tau and phosphorylated tau (...
Synaptic Neurofilaments and GluN1-Neurofilament Light Chain Interaction in Experimental Models of α-Synucleinopathies
Synaptic Neurofilaments and GluN1-Neurofilament Light Chain Interaction in Experimental Models of α-Synucleinopathies
<b><i>Introduction:</i></b> Although neurofilaments are mainly expressed in large caliber myelinat...
Association between Gut Microbiota with Mild Cognitive Impairment and Alzheimer’s Disease in a Thai Population
Association between Gut Microbiota with Mild Cognitive Impairment and Alzheimer’s Disease in a Thai Population
Background: Mild cognitive impairment (MCI) and Alzheimer's disease (AD) are common in older adults. Much recent work ...
Frontostriatal circuits alterations associated with cognitive flexibility deterioration in Huntington's disease
Frontostriatal circuits alterations associated with cognitive flexibility deterioration in Huntington's disease
Background: Recent resting-state functional magnetic resonance imaging studies have reported abnormal functional connectiv...
Hippocampal Functional Connectivity in Parkinson’s Disease
Hippocampal Functional Connectivity in Parkinson’s Disease
Background: While the hippocampus is not part of the nigrostriatal dopaminergic pathway, influence of Parkinson’s Disease ...
Synaptic neurofilaments and GluN1-NfL interaction in experimental models of α-synucleinopathies
Synaptic neurofilaments and GluN1-NfL interaction in experimental models of α-synucleinopathies
Introduction: despite neurofilaments are mainly expressed in large caliber myelinated axons, recent evidence supports the ...
Clinical and molecular findings of intermediate allele carriers in the HTT gene from the Mexican Mestizo population
Clinical and molecular findings of intermediate allele carriers in the HTT gene from the Mexican Mestizo population
Introduction: There are reports of different clinical statuses in carriers of intermediate alleles (IAs) of CAG trinucleot...
Contents Vol. 21, 2021
Contents Vol. 21, 2021
Neurodegenera...
Early Autonomic Symptoms Predict Functional Decline in Parkinson’s Disease Independent of Dopaminergic Therapy
Early Autonomic Symptoms Predict Functional Decline in Parkinson’s Disease Independent of Dopaminergic Therapy
Introduction: Parkinson’s disease (PD) has variable progression; identifying determinants of functional decline in PD is n...
Heart Rate Variability in Huntington Disease. A Long Term Longitudinal Study
Heart Rate Variability in Huntington Disease. A Long Term Longitudinal Study
Introduction: The aim of the study was to follow tonic and phasic autonomic nervous activity in Huntington disease (HD) mu...
Diagnostic accuracy of noun- and verb-naming tasks in detecting cognitive impairment in Parkinson’s disease
Diagnostic accuracy of noun- and verb-naming tasks in detecting cognitive impairment in Parkinson’s disease
Background. In Parkinson’s disease (PD), verb-naming tasks have been proposed as superior to noun-naming ones in detecting...
Juvenile-Onset Kufs Disease in a Chinese Consanguineous Family due to CLN6 Mutation
Juvenile-Onset Kufs Disease in a Chinese Consanguineous Family due to CLN6 Mutation
Objective: To identify the genetic cause of two cases of Kufs disease in the same family. The two affected individuals exh...
Distribution Changes of Neural Precursor Cells in the Brain Stem of Tg(SOD1*G93A)1Gur Mice
Distribution Changes of Neural Precursor Cells in the Brain Stem of Tg(SOD1*G93A)1Gur Mice
Objectives: The alteration of vimentin-containing cells (VCCs) proliferation, differentiation and migration in the brain s...
Neuroprotective and Therapeutic Effects of Tocovid and Twendee-X on Aβ Oligomer-Induced Damage in the SH-SY5Y Cell Line
Neuroprotective and Therapeutic Effects of Tocovid and Twendee-X on Aβ Oligomer-Induced Damage in the SH-SY5Y Cell Line
<b><i>Background:</i></b> Alzheimer’s disease (AD) is the most frequent cause of dementia among th...
Plasma Cystatin C correlates with plasma NfL levels and predicts disease progression in Parkinson’s disease
Plasma Cystatin C correlates with plasma NfL levels and predicts disease progression in Parkinson’s disease
Introduction: Previous studies reported increased plasma levels of Cystatin C (Cys-C) in Parkinson’s disease (PD) and clai...
Sexuality and Neurodegenerative Disease: An Unmet Challenge for Patients, Caregivers, and Treatment
Sexuality and Neurodegenerative Disease: An Unmet Challenge for Patients, Caregivers, and Treatment
<b><i>Background:</i></b> Many factors affect sexuality in the elderly such as dementia which is a...
Neuroprotective and therapeutic effects of Tocovid and Twendee-X on Aβ oligomers-induced damage in the SH-SY5Y cell line
Neuroprotective and therapeutic effects of Tocovid and Twendee-X on Aβ oligomers-induced damage in the SH-SY5Y cell line
Background: Alzheimer’s disease (AD) is the most frequent cause of dementia among the elderly. The accumulation of amyloid...
Inflammatory cytokine levels in patients with sporadic amyotrophic lateral sclerosis
Inflammatory cytokine levels in patients with sporadic amyotrophic lateral sclerosis
Objectives In the present study, inflammatory factors, including interleukin (IL) and tumor necrosis factor-α (TNF-α) in ...
Sexuality and neurodegenerative disease: An unmet challenge for patients, care-givers and treatment.
Sexuality and neurodegenerative disease: An unmet challenge for patients, care-givers and treatment.
Background: Many factors affect sexuality in the elderly such as dementia which is a common cause of inappropriate sexual...
Cancer in Parkinson’s Disease: An Approximation to the Main Risk Factors
Cancer in Parkinson’s Disease: An Approximation to the Main Risk Factors
<b><i>Background:</i></b> Many evidences suggest a pathological link between neurodegenerative dis...
Homoharringtonine inhibits Alzheimer’s disease progression by reducing neuroinflammation via STAT3 signaling in APP/PS1 mice
Homoharringtonine inhibits Alzheimer’s disease progression by reducing neuroinflammation via STAT3 signaling in APP/PS1 mice
Neurodegenera...
Contents Vol. 20, 2020
Contents Vol. 20, 2020
Neurodegenera...
Increased intake of fast acting carbohydrates in patients with Parkinson’s Disease
Increased intake of fast acting carbohydrates in patients with Parkinson’s Disease
Background: Patients with Parkinson’s Disease (PD) regularly report an increased desire for food or beverages with high su...
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