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BCL-2 overexpression exosomes promote the proliferation and migration of mesenchymal stem cells in hypoxic environment for skin injury in rats
BCL-2 overexpression exosomes promote the proliferation and migration of mesenchymal stem cells in hypoxic environment for skin injury in rats
The direction of this study was to detect and analyze the specific mechanism of anti-apoptosis in mesenchymal stem cells (...
Bioprocess exploitation of microaerobic auto-induction using the example of rhamnolipid biosynthesis in Pseudomonas putida KT2440
Bioprocess exploitation of microaerobic auto-induction using the example of rhamnolipid biosynthesis in Pseudomonas putida KT2440
In biomanufacturing of surface-active agents, such as rhamnolipids, excessive foaming is a significant obstacle for the de...
Engineering Yarrowia lipolytica for the production of β-carotene by carbon and redox rebalancing
Engineering Yarrowia lipolytica for the production of β-carotene by carbon and redox rebalancing
β-Carotene is a natural product that has garnered significant commercial interest. Considerable efforts have been mad...
Scale-up of CHO cell cultures: from 96-well-microtiter plates to stirred tank reactors across three orders of magnitude
Scale-up of CHO cell cultures: from 96-well-microtiter plates to stirred tank reactors across three orders of magnitude
For process development in mammalian cell cultivations, scale-up approaches are essential. A lot of studies concern the sc...
Stabilizing milk-derived extracellular vesicles (mEVs) through lyophilization: a novel trehalose and tryptophan formulation for maintaining structure and Bioactivity during long-term storage
Stabilizing milk-derived extracellular vesicles (mEVs) through lyophilization: a novel trehalose and tryptophan formulation for maintaining structure and Bioactivity during long-term storage
Extracellular vesicles (EVs) are widely investigated for their implications in cell-cell signaling, immune modulation, dis...
Lithium-doped calcium silicate cement regulates the immune microenvironment and promotes M2 macrophage polarization for enhancing bone regeneration
Lithium-doped calcium silicate cement regulates the immune microenvironment and promotes M2 macrophage polarization for enhancing bone regeneration
Bone defects present a significant challenge in orthopedics and trauma surgery, necessitating innovative approaches to sti...
Synthesizing hybrid copper phosphate (Cu3(PO4)2) nanoflowers using Cu+2 and shed snakeskin: antioxidant, antibacterial, anticancer, guaiacol, anionic, and cationic dye degradation properties
Synthesizing hybrid copper phosphate (Cu3(PO4)2) nanoflowers using Cu+2 and shed snakeskin: antioxidant, antibacterial, anticancer, guaiacol, anionic, and cationic dye degradation properties
Synthesis of organic@inorganic hNFs is achieved by the coordination of organic compounds containing amine, amide, and diol...
Advanced metabolic Engineering strategies for the sustainable production of free fatty acids and their derivatives using yeast
Advanced metabolic Engineering strategies for the sustainable production of free fatty acids and their derivatives using yeast
The biological production of lipids presents a sustainable method for generating fuels and chemicals. Recognized as safe a...
Glutathione peroxidase 4 overexpression induces anomalous subdiffusion and impairs glioblastoma cell growth
Glutathione peroxidase 4 overexpression induces anomalous subdiffusion and impairs glioblastoma cell growth
Glioblastoma tumors are the most common and aggressive adult central nervous system malignancy. Nearly all patients experi...
Dynamic control of the plasmid copy number maintained without antibiotics in Escherichia coli
Dynamic control of the plasmid copy number maintained without antibiotics in Escherichia coli
Manipulating the gene expression is the key strategy to optimize the metabolic flux. Not only transcription, translation, ...
Identification and verification of diagnostic biomarkers for deep infiltrating endometriosis based on machine learning algorithms
Identification and verification of diagnostic biomarkers for deep infiltrating endometriosis based on machine learning algorithms
This study addresses the challenges in the early diagnosis of deep infiltrating endometriosis (DIE) by exploring the poten...
Engineering Saccharomyces cerevisiae for the production of natural osmolyte glucosyl glycerol from sucrose and glycerol through Ccw12-based surface display of sucrose phosphorylase
Engineering Saccharomyces cerevisiae for the production of natural osmolyte glucosyl glycerol from sucrose and glycerol through Ccw12-based surface display of sucrose phosphorylase
Yeast Saccharomyces cerevisiae is widely recognised as a versatile chassis for constructing microbial cell factories. Howe...
A dual-inducible control system for multistep biosynthetic pathways
A dual-inducible control system for multistep biosynthetic pathways
The successful production of industrially relevant natural products hinges on two key factors: the cultivation of robust m...
Thermo-amplifier circuit in probiotic E. coli for stringently temperature-controlled release of a novel antibiotic
Thermo-amplifier circuit in probiotic E. coli for stringently temperature-controlled release of a novel antibiotic
Peptide drugs have seen rapid advancement in biopharmaceutical development, with over 80 candidates approved globally. Des...
A rotenone organotypic whole hemisphere slice model of mitochondrial abnormalities in the neonatal brain
A rotenone organotypic whole hemisphere slice model of mitochondrial abnormalities in the neonatal brain
Mitochondrial abnormalities underscore a variety of neurologic injuries and diseases and are well-studied in adult populat...
High-throughput proliferation and activation of NK-92MI cell spheroids via a homemade one-step closed bioreactor in pseudostatic cultures for immunocellular therapy
High-throughput proliferation and activation of NK-92MI cell spheroids via a homemade one-step closed bioreactor in pseudostatic cultures for immunocellular therapy
The NK-92MI cell line has displayed significant promise in clinical trials for cancer treatment. However, challenges persi...
Construction of multilayered gene circuits using de-novo-designed synthetic transcriptional regulators in cell-free systems
Construction of multilayered gene circuits using de-novo-designed synthetic transcriptional regulators in cell-free systems
De-novo-designed synthetic transcriptional regulators have great potential as the genetic parts for constructing complex m...
Evaluating ATP testing for distribution system monitoring: comparison to HPC, impact of chlorine quenching, and hold time dependency
Evaluating ATP testing for distribution system monitoring: comparison to HPC, impact of chlorine quenching, and hold time dependency
Adenosine triphosphate (ATP) assays have a faster turnaround time and higher sensitivity than traditional cultivation meth...
Biovalorization of whey waste as economic nutriment for mycogenic production of single cell oils with promising antibiofilm and anticancer potentiality
Biovalorization of whey waste as economic nutriment for mycogenic production of single cell oils with promising antibiofilm and anticancer potentiality
The production of value-added bio-compounds from rejuvenated sources and their recruitment for healthcare services are par...
Integrative analysis of gene expression, protein abundance, and metabolomic profiling elucidates complex relationships in chronic hyperglycemia-induced changes in human aortic smooth muscle cells
Integrative analysis of gene expression, protein abundance, and metabolomic profiling elucidates complex relationships in chronic hyperglycemia-induced changes in human aortic smooth muscle cells
Type 2 diabetes mellitus (T2DM) is a major public health concern with significant cardiovascular complications (CVD). Desp...
Phytoconstituents of Withania somnifera (L.) Dunal (Ashwagandha) unveiled potential cerebroside sulfotransferase inhibitors: insight through virtual screening, molecular dynamics, toxicity, and reverse pharmacophore analysis
Phytoconstituents of Withania somnifera (L.) Dunal (Ashwagandha) unveiled potential cerebroside sulfotransferase inhibitors: insight through virtual screening, molecular dynamics, toxicity, and reverse pharmacophore analysis
Cerebroside sulfotransferase (CST) is considered as therapeutic target for substrate reduction therapy (SRT) for metachrom...
Chitosan biomineralized with ions-doped nano-hydroxyapatite tunes osteoblasts metabolism and DNA damage
Chitosan biomineralized with ions-doped nano-hydroxyapatite tunes osteoblasts metabolism and DNA damage
Hydroxyapatite (HA) is a bioceramic material widely used as a bone biomimetic substitute and can be synthesized by biomine...
Microglia morphological response to mesenchymal stromal cell extracellular vesicles demonstrates EV therapeutic potential for modulating neuroinflammation
Microglia morphological response to mesenchymal stromal cell extracellular vesicles demonstrates EV therapeutic potential for modulating neuroinflammation
Mesenchymal stromal cell derived extracellular vesicles (MSC-EVs) are a promising therapeutic for neuroinflammation. MSC-E...
Construction of bispecific antibodies by specific pairing between the heavy chain and the light chain using removable SpyCatcher/SnoopCatcher units
Construction of bispecific antibodies by specific pairing between the heavy chain and the light chain using removable SpyCatcher/SnoopCatcher units
During the production of bispecific antibodies (bsAbs), nonspecific pairing results in low yields of target bsAb molecules...
Enhancing fatty acid and omega-3 production in Schizochytrium sp. using developed safe-harboring expression system
Enhancing fatty acid and omega-3 production in Schizochytrium sp. using developed safe-harboring expression system
Schizochytrium, a group of eukaryotic marine protists, is an oleaginous strain, making it a highly promising candidate for...
Probing the orthogonality and robustness of the mammalian RNA-binding protein Musashi-1 in Escherichia coli
Probing the orthogonality and robustness of the mammalian RNA-binding protein Musashi-1 in Escherichia coli
RNA recognition motifs (RRMs) are widespread RNA-binding protein domains in eukaryotes, which represent promising syntheti...
Integrating allele-specific PCR with CRISPR-Cas13a for sensitive KRAS mutation detection in pancreatic cancer
Integrating allele-specific PCR with CRISPR-Cas13a for sensitive KRAS mutation detection in pancreatic cancer
The clustered regulatory interspaced short palindromic repeats (CRISPR)-Cas13a system has strong potential for highly sens...
Avoiding overflow metabolite formation in Komagataella phaffii fermentations to enhance recombinant protein production
Avoiding overflow metabolite formation in Komagataella phaffii fermentations to enhance recombinant protein production
Komagataella phaffii (K. phaffii), formerly known as Pichia pastoris, is a widely utilized yeast for recombinant protein p...
Investigation of pH-dependent Paclitaxel delivery mechanism employing Chitosan-Eudragit bioresponsive nanocarriers: a molecular dynamics simulation
Investigation of pH-dependent Paclitaxel delivery mechanism employing Chitosan-Eudragit bioresponsive nanocarriers: a molecular dynamics simulation
Before embarking on any experimental research endeavor, it is advisable to do a mathematical computation and thoroughly ex...
Current advances in Hepatitis C diagnostics
Current advances in Hepatitis C diagnostics
Nearly 60 million people worldwide are infected with Hepatitis C Virus (HCV), a bloodborne pathogen which leads to liver c...
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