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Thermo-amplifier circuit in probiotic E. coli for stringently temperature-controlled release of a novel antibiotic
Thermo-amplifier circuit in probiotic E. coli for stringently temperature-controlled release of a novel antibiotic
Peptide drugs have seen rapid advancement in biopharmaceutical development, with over 80 candidates approved globally. Des...
A rotenone organotypic whole hemisphere slice model of mitochondrial abnormalities in the neonatal brain
A rotenone organotypic whole hemisphere slice model of mitochondrial abnormalities in the neonatal brain
Mitochondrial abnormalities underscore a variety of neurologic injuries and diseases and are well-studied in adult populat...
High-throughput proliferation and activation of NK-92MI cell spheroids via a homemade one-step closed bioreactor in pseudostatic cultures for immunocellular therapy
High-throughput proliferation and activation of NK-92MI cell spheroids via a homemade one-step closed bioreactor in pseudostatic cultures for immunocellular therapy
The NK-92MI cell line has displayed significant promise in clinical trials for cancer treatment. However, challenges persi...
Construction of multilayered gene circuits using de-novo-designed synthetic transcriptional regulators in cell-free systems
Construction of multilayered gene circuits using de-novo-designed synthetic transcriptional regulators in cell-free systems
De-novo-designed synthetic transcriptional regulators have great potential as the genetic parts for constructing complex m...
Evaluating ATP testing for distribution system monitoring: comparison to HPC, impact of chlorine quenching, and hold time dependency
Evaluating ATP testing for distribution system monitoring: comparison to HPC, impact of chlorine quenching, and hold time dependency
Adenosine triphosphate (ATP) assays have a faster turnaround time and higher sensitivity than traditional cultivation meth...
Biovalorization of whey waste as economic nutriment for mycogenic production of single cell oils with promising antibiofilm and anticancer potentiality
Biovalorization of whey waste as economic nutriment for mycogenic production of single cell oils with promising antibiofilm and anticancer potentiality
The production of value-added bio-compounds from rejuvenated sources and their recruitment for healthcare services are par...
Integrative analysis of gene expression, protein abundance, and metabolomic profiling elucidates complex relationships in chronic hyperglycemia-induced changes in human aortic smooth muscle cells
Integrative analysis of gene expression, protein abundance, and metabolomic profiling elucidates complex relationships in chronic hyperglycemia-induced changes in human aortic smooth muscle cells
Type 2 diabetes mellitus (T2DM) is a major public health concern with significant cardiovascular complications (CVD). Desp...
Phytoconstituents of Withania somnifera (L.) Dunal (Ashwagandha) unveiled potential cerebroside sulfotransferase inhibitors: insight through virtual screening, molecular dynamics, toxicity, and reverse pharmacophore analysis
Phytoconstituents of Withania somnifera (L.) Dunal (Ashwagandha) unveiled potential cerebroside sulfotransferase inhibitors: insight through virtual screening, molecular dynamics, toxicity, and reverse pharmacophore analysis
Cerebroside sulfotransferase (CST) is considered as therapeutic target for substrate reduction therapy (SRT) for metachrom...
Chitosan biomineralized with ions-doped nano-hydroxyapatite tunes osteoblasts metabolism and DNA damage
Chitosan biomineralized with ions-doped nano-hydroxyapatite tunes osteoblasts metabolism and DNA damage
Hydroxyapatite (HA) is a bioceramic material widely used as a bone biomimetic substitute and can be synthesized by biomine...
Microglia morphological response to mesenchymal stromal cell extracellular vesicles demonstrates EV therapeutic potential for modulating neuroinflammation
Microglia morphological response to mesenchymal stromal cell extracellular vesicles demonstrates EV therapeutic potential for modulating neuroinflammation
Mesenchymal stromal cell derived extracellular vesicles (MSC-EVs) are a promising therapeutic for neuroinflammation. MSC-E...
Construction of bispecific antibodies by specific pairing between the heavy chain and the light chain using removable SpyCatcher/SnoopCatcher units
Construction of bispecific antibodies by specific pairing between the heavy chain and the light chain using removable SpyCatcher/SnoopCatcher units
During the production of bispecific antibodies (bsAbs), nonspecific pairing results in low yields of target bsAb molecules...
Enhancing fatty acid and omega-3 production in Schizochytrium sp. using developed safe-harboring expression system
Enhancing fatty acid and omega-3 production in Schizochytrium sp. using developed safe-harboring expression system
Schizochytrium, a group of eukaryotic marine protists, is an oleaginous strain, making it a highly promising candidate for...
Probing the orthogonality and robustness of the mammalian RNA-binding protein Musashi-1 in Escherichia coli
Probing the orthogonality and robustness of the mammalian RNA-binding protein Musashi-1 in Escherichia coli
RNA recognition motifs (RRMs) are widespread RNA-binding protein domains in eukaryotes, which represent promising syntheti...
Integrating allele-specific PCR with CRISPR-Cas13a for sensitive KRAS mutation detection in pancreatic cancer
Integrating allele-specific PCR with CRISPR-Cas13a for sensitive KRAS mutation detection in pancreatic cancer
The clustered regulatory interspaced short palindromic repeats (CRISPR)-Cas13a system has strong potential for highly sens...
Avoiding overflow metabolite formation in Komagataella phaffii fermentations to enhance recombinant protein production
Avoiding overflow metabolite formation in Komagataella phaffii fermentations to enhance recombinant protein production
Komagataella phaffii (K. phaffii), formerly known as Pichia pastoris, is a widely utilized yeast for recombinant protein p...
Investigation of pH-dependent Paclitaxel delivery mechanism employing Chitosan-Eudragit bioresponsive nanocarriers: a molecular dynamics simulation
Investigation of pH-dependent Paclitaxel delivery mechanism employing Chitosan-Eudragit bioresponsive nanocarriers: a molecular dynamics simulation
Before embarking on any experimental research endeavor, it is advisable to do a mathematical computation and thoroughly ex...
Current advances in Hepatitis C diagnostics
Current advances in Hepatitis C diagnostics
Nearly 60 million people worldwide are infected with Hepatitis C Virus (HCV), a bloodborne pathogen which leads to liver c...
Soil microbiome characterization and its future directions with biosensing
Soil microbiome characterization and its future directions with biosensing
Soil microbiome characterization is typically achieved with next-generation sequencing (NGS) techniques. Metabarcoding is ...
Epithelial cell-cell interactions in an overcrowded environment: jamming or live cell extrusion
Epithelial cell-cell interactions in an overcrowded environment: jamming or live cell extrusion
Epithelial tissues respond strongly to the mechanical stress caused by collective cell migration and are able to regulate ...
Hyperactivation of crosslinked lipases in elastic hydroxyapatite microgel and their properties
Hyperactivation of crosslinked lipases in elastic hydroxyapatite microgel and their properties
Effective enzyme stabilization through immobilization is essential for the functional usage of enzymatic reactions. We pro...
Oxygenator assisted dynamic microphysiological culture elucidates the impact of hypoxia on valvular interstitial cell calcification
Oxygenator assisted dynamic microphysiological culture elucidates the impact of hypoxia on valvular interstitial cell calcification
Microphysiological systems (MPS) offer simulation of (patho)physiological parameters. Investigation includes items which l...
Enhancing bioprocessing of red pigment from immobilized culture of gamma rays mutant of the endophytic fungus Monascus ruber SRZ112
Enhancing bioprocessing of red pigment from immobilized culture of gamma rays mutant of the endophytic fungus Monascus ruber SRZ112
Considerable attention has been paid to exploring the biotechnological applications of several Monascus sp. for pigment pr...
Unraveling pathogenesis, biomarkers and potential therapeutic agents for endometriosis associated with disulfidptosis based on bioinformatics analysis, machine learning and experiment validation
Unraveling pathogenesis, biomarkers and potential therapeutic agents for endometriosis associated with disulfidptosis based on bioinformatics analysis, machine learning and experiment validation
Endometriosis (EMs) is an enigmatic disease of yet-unknown pathogenesis. Disulfidptosis, a novel identified form of progra...
Advances in the application of gas vesicles in medical imaging and disease treatment
Advances in the application of gas vesicles in medical imaging and disease treatment
The gas vesicle (GV) is like a hollow nanoparticle consisting of an internal gas and a protein shell, which mainly consist...
Frontier and hot topics in the application of hydrogel in the biomedical field: a bibliometric analysis based on CiteSpace
Frontier and hot topics in the application of hydrogel in the biomedical field: a bibliometric analysis based on CiteSpace
Hydrogels are formed of crosslinked polymer chains arranged in three-dimensional (3D) networks. These chains have good wat...
Isolation methods and characterization of primary rat neurovascular cells
Isolation methods and characterization of primary rat neurovascular cells
There is significant interest in isolating cells of the blood-brain barrier (BBB) for use in in vitro screening of therape...
Synthesis of metformin-derived fluorescent quantum dots: uptake, cytotoxicity, and inhibition in human breast cancer cells through autophagy pathway
Synthesis of metformin-derived fluorescent quantum dots: uptake, cytotoxicity, and inhibition in human breast cancer cells through autophagy pathway
Breast cancer remains a challenge for physicians. Metformin, an antidiabetic drug, show promising anticancer properties ag...
Hypoxia and re-oxygenation effects on human cardiomyocytes cultured on polycaprolactone and polyurethane nanofibrous mats
Hypoxia and re-oxygenation effects on human cardiomyocytes cultured on polycaprolactone and polyurethane nanofibrous mats
Heart diseases are caused mainly by chronic oxygen insufficiency (hypoxia), leading to damage and apoptosis of cardiomyocy...
Role of mesenchymal stem cell-derived exosomes in the regeneration of different tissues
Role of mesenchymal stem cell-derived exosomes in the regeneration of different tissues
Exosomes are nanovesicles with multiple components used in several applications. Mesenchymal stem cells (MSCs) are well kn...
Nonthermal biocompatible plasma in stimulating osteogenic differentiation by targeting p38/ FOXO1 and PI3K/AKT pathways in hBMSCs
Nonthermal biocompatible plasma in stimulating osteogenic differentiation by targeting p38/ FOXO1 and PI3K/AKT pathways in hBMSCs
Osteoporosis is manifested by decreased bone density and deterioration of bone architecture, increasing the risk of bone f...
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