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Are oligodendrocytes the missing link in Alzheimer’s disease and related dementia research?
Are oligodendrocytes the missing link in Alzheimer’s disease and related dementia research?
Auguste YSS, Ferro A, Kahng JA, Xavier AM, Dixon JR, Vrudhula U, et al. Oligodendrocyte precursor cells engulf synapses du...
Contribution of amyloid deposition from oligodendrocytes in a mouse model of Alzheimer’s disease
Contribution of amyloid deposition from oligodendrocytes in a mouse model of Alzheimer’s disease
The accumulation of β-amyloid (Aβ) peptides into insoluble plaques is an early pathological feature of Alzheimer...
CSF proteins of inflammation, proteolysis and lipid transport define preclinical AD and progression to AD dementia in cognitively unimpaired individuals
CSF proteins of inflammation, proteolysis and lipid transport define preclinical AD and progression to AD dementia in cognitively unimpaired individuals
This preclinical AD CSF proteome study identified a panel of 12-CSF markers detecting amyloid positivity and clinical prog...
Proteomic analysis of APOEε4 carriers implicates lipid metabolism, complement and lymphocyte signaling in cognitive resilience
Proteomic analysis of APOEε4 carriers implicates lipid metabolism, complement and lymphocyte signaling in cognitive resilience
Apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for late onset Alzheimer’s disease (AD)....
Gut-first Parkinson’s disease is encoded by gut dysbiome
Gut-first Parkinson’s disease is encoded by gut dysbiome
In Parkinson's patients, intestinal dysbiosis can occur years before clinical diagnosis, implicating the gut and its m...
Repetitive transcranial magnetic stimulation alleviates motor impairment in Parkinson’s disease: association with peripheral inflammatory regulatory T-cells and SYT6
Repetitive transcranial magnetic stimulation alleviates motor impairment in Parkinson’s disease: association with peripheral inflammatory regulatory T-cells and SYT6
Repetitive transcranial magnetic stimulation (rTMS) has been used to treat various neurological disorders. However, the mo...
HDGFL2 cryptic protein: a portal to detection and diagnosis in neurodegenerative disease
HDGFL2 cryptic protein: a portal to detection and diagnosis in neurodegenerative disease
Neumann M, Sampathu DM, Kwong LK, Truax AC, Micsenyi MC, Chou TT, et al. Ubiquitinated TDP-43 in frontotemporal lobar dege...
Amyloid-β (Aβ) immunotherapy induced microhemorrhages are linked to vascular inflammation and cerebrovascular damage in a mouse model of Alzheimer’s disease
Amyloid-β (Aβ) immunotherapy induced microhemorrhages are linked to vascular inflammation and cerebrovascular damage in a mouse model of Alzheimer’s disease
Anti-amyloid-β (Aβ) immunotherapy trials have revealed amyloid-related imaging abnormalities (ARIA) as the most ...
Increased expression of mesencephalic astrocyte-derived neurotrophic factor (MANF) contributes to synapse loss in Alzheimer’s disease
Increased expression of mesencephalic astrocyte-derived neurotrophic factor (MANF) contributes to synapse loss in Alzheimer’s disease
The activation of endoplasmic reticulum (ER) stress is an early pathological hallmark of Alzheimer’s disease (AD) br...
Comparing anti-tau antibodies under clinical trials and their epitopes on tau pathologies
Comparing anti-tau antibodies under clinical trials and their epitopes on tau pathologies
Yang J, Shen N, Shen J, Yang Y, Li HL. Complicated role of post-translational modification and protease-cleaved fragments ...
A perspective on Alzheimer’s disease: exploring the potential of terminal/paradoxical lucidity and psychedelics
A perspective on Alzheimer’s disease: exploring the potential of terminal/paradoxical lucidity and psychedelics
DeTure MA, Dickson DW. The neuropathological diagnosis of Alzheimer’s disease. Mol Neurodegener. 2019;14:32.Article  P...
Correction: Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia in a sex-specific manner
Correction: Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia in a sex-specific manner
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
α-Synuclein pathology disrupts mitochondrial function in dopaminergic and cholinergic neurons at-risk in Parkinson’s disease
α-Synuclein pathology disrupts mitochondrial function in dopaminergic and cholinergic neurons at-risk in Parkinson’s disease
Pathological accumulation of aggregated α-synuclein (aSYN) is a common feature of Parkinson’s disease (PD). How...
Clarifying the association of CSF Aβ, tau, BACE1, and neurogranin with AT(N) stages in Alzheimer disease
Clarifying the association of CSF Aβ, tau, BACE1, and neurogranin with AT(N) stages in Alzheimer disease
Current AT(N) stratification for Alzheimer’s disease (AD) accounts for complex combinations of amyloid (A), tau prot...
Heparin-enriched plasma proteome is significantly altered in Alzheimer’s disease
Heparin-enriched plasma proteome is significantly altered in Alzheimer’s disease
Heparin binding proteins (HBPs) with roles in extracellular matrix assembly are strongly correlated to β-amyloid (A&#...
One immune cell to bind them all: platelet contribution to neurodegenerative disease
One immune cell to bind them all: platelet contribution to neurodegenerative disease
Alzheimer’s disease (AD) and related dementias (ADRD) collectively affect a significant portion of the aging populat...
Regional desynchronization of microglial activity is associated with cognitive decline in Alzheimer’s disease
Regional desynchronization of microglial activity is associated with cognitive decline in Alzheimer’s disease
Microglial activation is one hallmark of Alzheimer disease (AD) neuropathology but the impact of the regional interplay of...
Pathological characteristics of axons and alterations of proteomic and lipidomic profiles in midbrain dopaminergic neurodegeneration induced by WDR45-deficiency
Pathological characteristics of axons and alterations of proteomic and lipidomic profiles in midbrain dopaminergic neurodegeneration induced by WDR45-deficiency
Although WD repeat domain 45 (WDR45) mutations have been linked to $$\upbeta$$ -propeller protein-associated neurodegenera...
Identification of a specific APOE transcript and functional elements associated with Alzheimer’s disease
Identification of a specific APOE transcript and functional elements associated with Alzheimer’s disease
The APOE gene is the strongest genetic risk factor for late-onset Alzheimer’s Disease (LOAD). However, the gene regu...
Network proteomics of the Lewy body dementia brain reveals presynaptic signatures distinct from Alzheimer’s disease
Network proteomics of the Lewy body dementia brain reveals presynaptic signatures distinct from Alzheimer’s disease
Lewy body dementia (LBD), a class of disorders comprising Parkinson’s disease dementia (PDD) and dementia with Lewy ...
Astrocytic autophagy plasticity modulates Aβ clearance and cognitive function in Alzheimer’s disease
Astrocytic autophagy plasticity modulates Aβ clearance and cognitive function in Alzheimer’s disease
Astrocytes, one of the most resilient cells in the brain, transform into reactive astrocytes in response to toxic proteins...
Correction: HDGFL2 cryptic proteins report presence of TDP-43 pathology in neurodegenerative diseases
Correction: HDGFL2 cryptic proteins report presence of TDP-43 pathology in neurodegenerative diseases
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Therapeutic potential of APP antisense oligonucleotides for Alzheimer’s disease and down syndrome-related Alzheimer’s disease
Therapeutic potential of APP antisense oligonucleotides for Alzheimer’s disease and down syndrome-related Alzheimer’s disease
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Astrocyte reactivity is associated with tau tangle load and cortical thinning in Alzheimer’s disease
Astrocyte reactivity is associated with tau tangle load and cortical thinning in Alzheimer’s disease
It is not fully established whether plasma β-amyloid(Aβ)42/Aβ40 and phosphorylated Tau181 (p-Tau181) can ef...
Single-cell peripheral immunoprofiling of lewy body and Parkinson’s disease in a multi-site cohort
Single-cell peripheral immunoprofiling of lewy body and Parkinson’s disease in a multi-site cohort
Multiple lines of evidence support peripheral organs in the initiation or progression of Lewy body disease (LBD), a spectr...
The interplay of inflammation and remyelination: rethinking MS treatment with a focus on oligodendrocyte progenitor cells
The interplay of inflammation and remyelination: rethinking MS treatment with a focus on oligodendrocyte progenitor cells
Multiple sclerosis (MS) therapeutic goals have traditionally been dichotomized into two distinct avenues: immune-modulator...
Anti-acetylated-tau immunotherapy is neuroprotective in tauopathy and brain injury
Anti-acetylated-tau immunotherapy is neuroprotective in tauopathy and brain injury
Tau is aberrantly acetylated in various neurodegenerative conditions, including Alzheimer’s disease, frontotemporal ...
Mis-localization of endogenous TDP-43 leads to ALS-like early-stage metabolic dysfunction and progressive motor deficits
Mis-localization of endogenous TDP-43 leads to ALS-like early-stage metabolic dysfunction and progressive motor deficits
The key pathological signature of ALS/ FTLD is the mis-localization of endogenous TDP-43 from the nucleus to the cytoplasm...
Urolithin A promotes p62-dependent lysophagy to prevent acute retinal neurodegeneration
Urolithin A promotes p62-dependent lysophagy to prevent acute retinal neurodegeneration
Age-related macular degeneration (AMD) is the leading cause of blindness in elderly people in the developed world, and the...
Fate-mapping and functional dissection reveal perilous influence of type I interferon signaling in mouse brain aging
Fate-mapping and functional dissection reveal perilous influence of type I interferon signaling in mouse brain aging
Aging significantly elevates the risk of developing neurodegenerative diseases. Neuroinflammation is a universal hallmark ...
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