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Mitovesicles secreted into the extracellular space of brains with mitochondrial dysfunction impair synaptic plasticity
Mitovesicles secreted into the extracellular space of brains with mitochondrial dysfunction impair synaptic plasticity
Hypometabolism tied to mitochondrial dysfunction occurs in the aging brain and in neurodegenerative disorders, including i...
The concept of resilience to Alzheimer’s Disease: current definitions and cellular and molecular mechanisms
The concept of resilience to Alzheimer’s Disease: current definitions and cellular and molecular mechanisms
Some individuals are able to maintain their cognitive abilities despite the presence of significant Alzheimer’s Dise...
Regulatory T cells limit age-associated retinal inflammation and neurodegeneration
Regulatory T cells limit age-associated retinal inflammation and neurodegeneration
Ageing is the principal risk factor for retinal degenerative diseases, which are the commonest cause of blindness in the d...
An adapted protocol to derive microglia from stem cells and its application in the study of CSF1R-related disorders
An adapted protocol to derive microglia from stem cells and its application in the study of CSF1R-related disorders
Induced pluripotent stem cell-derived microglia (iMGL) represent an excellent tool in studying microglial function in heal...
The endotoxin hypothesis of Alzheimer’s disease
The endotoxin hypothesis of Alzheimer’s disease
Lipopolysaccharide (LPS) constitutes much of the surface of Gram-negative bacteria, and if LPS enters the human body or br...
HDGFL2 cryptic proteins report presence of TDP-43 pathology in neurodegenerative diseases
HDGFL2 cryptic proteins report presence of TDP-43 pathology in neurodegenerative diseases
This letter demonstrates the potential of novel cryptic proteins resulting from TAR DNA-binding protein 43 (TDP-43) dysfun...
A partial Drp1 knockout improves autophagy flux independent of mitochondrial function
A partial Drp1 knockout improves autophagy flux independent of mitochondrial function
Dynamin-related protein 1 (Drp1) plays a critical role in mitochondrial dynamics. Partial inhibition of this protein is pr...
Rejuvenating aged microglia by p16ink4a-siRNA-loaded nanoparticles increases amyloid-β clearance in animal models of Alzheimer’s disease
Rejuvenating aged microglia by p16ink4a-siRNA-loaded nanoparticles increases amyloid-β clearance in animal models of Alzheimer’s disease
Age-dependent accumulation of amyloid plaques in patients with sporadic Alzheimer’s disease (AD) is associated with ...
APOE4 genotype and aging impair injury-induced microglial behavior in brain slices, including toward Aβ, through P2RY12
APOE4 genotype and aging impair injury-induced microglial behavior in brain slices, including toward Aβ, through P2RY12
Microglia are highly dynamic cells that play a critical role in tissue homeostasis through the surveillance of brain paren...
Updates on mouse models of Alzheimer’s disease
Updates on mouse models of Alzheimer’s disease
Alzheimer’s disease (AD) is the most common neurodegenerative disease in the United States (US). Animal models, spec...
GBA1 inactivation in oligodendrocytes affects myelination and induces neurodegenerative hallmarks and lipid dyshomeostasis in mice
GBA1 inactivation in oligodendrocytes affects myelination and induces neurodegenerative hallmarks and lipid dyshomeostasis in mice
Mutations in the β-glucocerebrosidase (GBA1) gene do cause the lysosomal storage Gaucher disease (GD) and are among t...
Misfolded protein oligomers: mechanisms of formation, cytotoxic effects, and pharmacological approaches against protein misfolding diseases
Misfolded protein oligomers: mechanisms of formation, cytotoxic effects, and pharmacological approaches against protein misfolding diseases
The conversion of native peptides and proteins into amyloid aggregates is a hallmark of over 50 human disorders, including...
Unraveling the dual nature of brain CD8+ T cells in Alzheimer’s disease
Unraveling the dual nature of brain CD8+ T cells in Alzheimer’s disease
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Correction: Collusion of α-Synuclein and Aβ aggravating co-morbidities in a novel prion-type mouse model
Correction: Collusion of α-Synuclein and Aβ aggravating co-morbidities in a novel prion-type mouse model
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Plasma N-terminal containing tau fragments (NTA-tau): a biomarker of tau deposition in Alzheimer’s Disease
Plasma N-terminal containing tau fragments (NTA-tau): a biomarker of tau deposition in Alzheimer’s Disease
Novel phosphorylated-tau (p-tau) blood biomarkers (e.g., p-tau181, p-tau217 or p-tau231), are highly specific for Alzheime...
Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia in a sex-specific manner
Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia in a sex-specific manner
It has recently become well-established that there is a connection between Alzheimer’s disease pathology and gut mic...
CSF protein ratios with enhanced potential to reflect Alzheimer’s disease pathology and neurodegeneration
CSF protein ratios with enhanced potential to reflect Alzheimer’s disease pathology and neurodegeneration
Amyloid and tau aggregates are considered to cause neurodegeneration and consequently cognitive decline in individuals wit...
Cognitive, functional, and neuropsychiatric correlates of regional tau pathology in autopsy-confirmed chronic traumatic encephalopathy
Cognitive, functional, and neuropsychiatric correlates of regional tau pathology in autopsy-confirmed chronic traumatic encephalopathy
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease characterized by hyperphosphorylated tau (p-tau) acc...
Microglial ferroptotic stress causes non-cell autonomous neuronal death
Microglial ferroptotic stress causes non-cell autonomous neuronal death
Ferroptosis is a form of regulated cell death characterised by lipid peroxidation as the terminal endpoint and a requireme...
NMNAT2 supports vesicular glycolysis via NAD homeostasis to fuel fast axonal transport
NMNAT2 supports vesicular glycolysis via NAD homeostasis to fuel fast axonal transport
Bioenergetic maladaptations and axonopathy are often found in the early stages of neurodegeneration. Nicotinamide adenine ...
Nuclear-import receptors as gatekeepers of pathological phase transitions in ALS/FTD
Nuclear-import receptors as gatekeepers of pathological phase transitions in ALS/FTD
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are fatal neurodegenerative disorders on a disease s...
Fluid biomarkers for amyotrophic lateral sclerosis: a review
Fluid biomarkers for amyotrophic lateral sclerosis: a review
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the loss of upper and lower moto...
Mitochondrial CISD1/Cisd accumulation blocks mitophagy and genetic or pharmacological inhibition rescues neurodegenerative phenotypes in Pink1/parkin models
Mitochondrial CISD1/Cisd accumulation blocks mitophagy and genetic or pharmacological inhibition rescues neurodegenerative phenotypes in Pink1/parkin models
Mitochondrial dysfunction and toxic protein aggregates have been shown to be key features in the pathogenesis of neurodege...
Collagen in the central nervous system: contributions to neurodegeneration and promise as a therapeutic target
Collagen in the central nervous system: contributions to neurodegeneration and promise as a therapeutic target
The extracellular matrix is a richly bioactive composition of substrates that provides biophysical stability, facilitates ...
Unravelling cell type-specific responses to Parkinson’s Disease at single cell resolution
Unravelling cell type-specific responses to Parkinson’s Disease at single cell resolution
Parkinson’s Disease (PD) is the second most common neurodegenerative disorder. The pathological hallmark of PD is lo...
Real-time imaging of mitochondrial redox reveals increased mitochondrial oxidative stress associated with amyloid β aggregates in vivo in a mouse model of Alzheimer’s disease
Real-time imaging of mitochondrial redox reveals increased mitochondrial oxidative stress associated with amyloid β aggregates in vivo in a mouse model of Alzheimer’s disease
Reactive oxidative stress is a critical player in the amyloid beta (Aβ) toxicity that contributes to neurodegeneratio...
Brain clearance of protein aggregates: a close-up on astrocytes
Brain clearance of protein aggregates: a close-up on astrocytes
Protein misfolding and accumulation defines a prevailing feature of many neurodegenerative disorders, finally resulting in...
Neuronal and glial vulnerability of the suprachiasmatic nucleus in tauopathies: evidence from human studies and animal models
Neuronal and glial vulnerability of the suprachiasmatic nucleus in tauopathies: evidence from human studies and animal models
Tauopathies, a group of neurodegenerative diseases that includes Alzheimer’s disease, commonly lead to disturbances ...
Blood platelet factor 4: the elixir of brain rejuvenation
Blood platelet factor 4: the elixir of brain rejuvenation
Aging is invariably associated with some form of cognitive impairment. Three recently published articles in Nature family ...
Comparison of immunoassay- with mass spectrometry-derived p-tau quantification for the detection of Alzheimer’s disease pathology
Comparison of immunoassay- with mass spectrometry-derived p-tau quantification for the detection of Alzheimer’s disease pathology
Antibody-based immunoassays have enabled quantification of very low concentrations of phosphorylated tau (p-tau) protein f...
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