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Chitinase-3-like-1: a multifaceted player in neuroinflammation and degenerative pathologies with therapeutic implications
Chitinase-3-like-1: a multifaceted player in neuroinflammation and degenerative pathologies with therapeutic implications
Chitinase-3-like-1 (CHI3L1) is an evolutionarily conserved protein involved in key biological processes, including tissue ...
SIRT2 and ALDH1A1 as critical enzymes for astrocytic GABA production in Alzheimer’s disease
SIRT2 and ALDH1A1 as critical enzymes for astrocytic GABA production in Alzheimer’s disease
Alzheimer’s Disease (AD) is a neurodegenerative disease with drastically altered astrocytic metabolism. Astrocytic G...
Upregulated astrocyte HDAC7 induces Alzheimer-like tau pathologies via deacetylating transcription factor-EB and inhibiting lysosome biogenesis
Upregulated astrocyte HDAC7 induces Alzheimer-like tau pathologies via deacetylating transcription factor-EB and inhibiting lysosome biogenesis
Astrocytes, the most abundant glial cell type in the brain, will convert into the reactive state in response to proteotoxi...
RNA-Targeting CRISPR/CasRx system relieves disease symptoms in Huntington’s disease models
RNA-Targeting CRISPR/CasRx system relieves disease symptoms in Huntington’s disease models
HD is a devastating neurodegenerative disorder caused by the expansion of CAG repeats in the HTT. Silencing the expression...
Biophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple Alzheimer’s disease ligands
Biophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple Alzheimer’s disease ligands
TREM2 is a signaling receptor expressed on microglia that has emerged as an important drug target for Alzheimer’s di...
VCP regulates early tau seed amplification via specific cofactors
VCP regulates early tau seed amplification via specific cofactors
Neurodegenerative tauopathies may progress based on seeding by pathological tau assemblies, whereby an aggregate is releas...
Positron emission tomography tracers for synucleinopathies
Positron emission tomography tracers for synucleinopathies
Synucleinopathies, such as Parkinson’s disease, dementia with Lewy bodies, and multiple system atrophy, are characte...
Distinct regulation of Tau Monomer and aggregate uptake and intracellular accumulation in human neurons
Distinct regulation of Tau Monomer and aggregate uptake and intracellular accumulation in human neurons
The prion-like spreading of Tau pathology is the leading cause of disease progression in various tauopathies. A critical s...
Targeted long-read sequencing to quantify methylation of the C9orf72 repeat expansion
Targeted long-read sequencing to quantify methylation of the C9orf72 repeat expansion
The gene C9orf72 harbors a non-coding hexanucleotide repeat expansion known to cause amyotrophic lateral sclerosis and fro...
The UFMylation pathway is impaired in Alzheimer’s disease
The UFMylation pathway is impaired in Alzheimer’s disease
Alzheimer’s disease (AD) is characterized by the presence of neurofibrillary tangles made of hyperphosphorylated tau...
Mystery of gamma wave stimulation in brain disorders
Mystery of gamma wave stimulation in brain disorders
Neuronal oscillations refer to rhythmic and periodic fluctuations of electrical activity in the central nervous system tha...
Microglial CD2AP deficiency exerts protection in an Alzheimer’s disease model of amyloidosis
Microglial CD2AP deficiency exerts protection in an Alzheimer’s disease model of amyloidosis
The CD2-associated protein (CD2AP) was initially identified in peripheral immune cells and regulates cytoskeleton and prot...
Dementia with lewy bodies patients with high tau levels display unique proteome profiles
Dementia with lewy bodies patients with high tau levels display unique proteome profiles
Clinical studies have long observed that neurodegenerative disorders display a range of symptoms and pathological features...
Aging-associated sensory decline and Alzheimer’s disease
Aging-associated sensory decline and Alzheimer’s disease
Multisensory decline is common as people age, and aging is the primary risk of Alzheimer’s Disease (AD). Recent stud...
NOTCH2NLC GGC intermediate repeat with serine induces hypermyelination and early Parkinson’s disease-like phenotypes in mice
NOTCH2NLC GGC intermediate repeat with serine induces hypermyelination and early Parkinson’s disease-like phenotypes in mice
The expansion of GGC repeats (typically exceeding 60 repeats) in the 5’ untranslated region (UTR) of the NOTCH2NLC g...
Seeding activity of skin misfolded tau as a biomarker for tauopathies
Seeding activity of skin misfolded tau as a biomarker for tauopathies
Tauopathies are a group of age-related neurodegenerative diseases characterized by the accumulation of pathologically hype...
Human VCP mutant ALS/FTD microglia display immune and lysosomal phenotypes independently of GPNMB
Human VCP mutant ALS/FTD microglia display immune and lysosomal phenotypes independently of GPNMB
Microglia play crucial roles in maintaining neuronal homeostasis but have been implicated in contributing to amyotrophic l...
A novel AAV Vector for gene therapy of RPE-related retinal degenerative diseases via intravitreal delivery
A novel AAV Vector for gene therapy of RPE-related retinal degenerative diseases via intravitreal delivery
This study was supported by the Key Research and Development Program of the Ministry of Science and Technology (2022YFF120...
The Parkinson’s disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons
The Parkinson’s disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons
Variants in the CTSB gene encoding the lysosomal hydrolase cathepsin B (catB) are associated with increased risk of Parkin...
Nuclear pore and nucleocytoplasmic transport impairment in oxidative stress-induced neurodegeneration: relevance to molecular mechanisms in Pathogenesis of Parkinson’s and other related neurodegenerative diseases
Nuclear pore and nucleocytoplasmic transport impairment in oxidative stress-induced neurodegeneration: relevance to molecular mechanisms in Pathogenesis of Parkinson’s and other related neurodegenerative diseases
Nuclear pore complexes (NPCs) are embedded in the nuclear envelope and facilitate the exchange of macromolecules between t...
Stearoyl-CoA desaturase-1: a potential therapeutic target for neurological disorders
Stearoyl-CoA desaturase-1: a potential therapeutic target for neurological disorders
Disturbances in the fatty acid lipidome are increasingly recognized as key drivers in the progression of various brain dis...
Regulation of disease-associated microglia in the optic nerve by lipoxin B4 and ocular hypertension
Regulation of disease-associated microglia in the optic nerve by lipoxin B4 and ocular hypertension
The resident astrocyte-retinal ganglion cell (RGC) lipoxin circuit is impaired during retinal stress, which includes ocula...
Are oligodendrocytes the missing link in Alzheimer’s disease and related dementia research?
Are oligodendrocytes the missing link in Alzheimer’s disease and related dementia research?
Auguste YSS, Ferro A, Kahng JA, Xavier AM, Dixon JR, Vrudhula U, et al. Oligodendrocyte precursor cells engulf synapses du...
Contribution of amyloid deposition from oligodendrocytes in a mouse model of Alzheimer’s disease
Contribution of amyloid deposition from oligodendrocytes in a mouse model of Alzheimer’s disease
The accumulation of β-amyloid (Aβ) peptides into insoluble plaques is an early pathological feature of Alzheimer...
CSF proteins of inflammation, proteolysis and lipid transport define preclinical AD and progression to AD dementia in cognitively unimpaired individuals
CSF proteins of inflammation, proteolysis and lipid transport define preclinical AD and progression to AD dementia in cognitively unimpaired individuals
This preclinical AD CSF proteome study identified a panel of 12-CSF markers detecting amyloid positivity and clinical prog...
Proteomic analysis of APOEε4 carriers implicates lipid metabolism, complement and lymphocyte signaling in cognitive resilience
Proteomic analysis of APOEε4 carriers implicates lipid metabolism, complement and lymphocyte signaling in cognitive resilience
Apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for late onset Alzheimer’s disease (AD)....
Gut-first Parkinson’s disease is encoded by gut dysbiome
Gut-first Parkinson’s disease is encoded by gut dysbiome
In Parkinson's patients, intestinal dysbiosis can occur years before clinical diagnosis, implicating the gut and its m...
Repetitive transcranial magnetic stimulation alleviates motor impairment in Parkinson’s disease: association with peripheral inflammatory regulatory T-cells and SYT6
Repetitive transcranial magnetic stimulation alleviates motor impairment in Parkinson’s disease: association with peripheral inflammatory regulatory T-cells and SYT6
Repetitive transcranial magnetic stimulation (rTMS) has been used to treat various neurological disorders. However, the mo...
HDGFL2 cryptic protein: a portal to detection and diagnosis in neurodegenerative disease
HDGFL2 cryptic protein: a portal to detection and diagnosis in neurodegenerative disease
Neumann M, Sampathu DM, Kwong LK, Truax AC, Micsenyi MC, Chou TT, et al. Ubiquitinated TDP-43 in frontotemporal lobar dege...
Amyloid-β (Aβ) immunotherapy induced microhemorrhages are linked to vascular inflammation and cerebrovascular damage in a mouse model of Alzheimer’s disease
Amyloid-β (Aβ) immunotherapy induced microhemorrhages are linked to vascular inflammation and cerebrovascular damage in a mouse model of Alzheimer’s disease
Anti-amyloid-β (Aβ) immunotherapy trials have revealed amyloid-related imaging abnormalities (ARIA) as the most ...
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