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Elevated ganglioside GM2 activator (GM2A) in human brain tissue reduces neurite integrity and spontaneous neuronal activity
Elevated ganglioside GM2 activator (GM2A) in human brain tissue reduces neurite integrity and spontaneous neuronal activity
Alzheimer’s Disease (AD) affects millions globally, but therapy development is lagging. New experimental systems tha...
Author response to “post-infection cognitive impairments in a cohort of elderly patients with COVID-19”
Author response to “post-infection cognitive impairments in a cohort of elderly patients with COVID-19”
Liu YH, Wang YR, Wang QH, Chen Y, Chen X, Li Y, et al. Post-infection cognitive impairments in a cohort of elderly patient...
Microglial TYROBP/DAP12 in Alzheimer’s disease: Transduction of physiological and pathological signals across TREM2
Microglial TYROBP/DAP12 in Alzheimer’s disease: Transduction of physiological and pathological signals across TREM2
TYROBP (also known as DAP12 or KARAP) is a transmembrane adaptor protein initially described as a receptor-activating subu...
CD8+ T cells in neurodegeneration: friend or foe?
CD8+ T cells in neurodegeneration: friend or foe?
T cell infiltration is enhanced in disease-associated brain areas in neurodegenerative diseases such as multiple sclerosi...
Trem2 deletion enhances tau dispersion and pathology through microglia exosomes
Trem2 deletion enhances tau dispersion and pathology through microglia exosomes
Alzheimer’s disease (AD) is a neurodegenerative disorder that manifests sequential Aβ and tau brain pathology w...
When the infectious environment meets the AD brain
When the infectious environment meets the AD brain
The Amyloid theory of Alzheimer’s disease (AD) suggests that the deposition of Amyloid β (Aβ) in the brain...
APOE targeting strategy in Alzheimer’s disease: lessons learned from protective variants
APOE targeting strategy in Alzheimer’s disease: lessons learned from protective variants
Yamazaki Y, Zhao N, Caulfield TR, Liu CC, Bu G. Apolipoprotein E and Alzheimer disease: pathobiology and targeting strateg...
Combination therapy using GDNF and cell transplant in Parkinson’s disease
Combination therapy using GDNF and cell transplant in Parkinson’s disease
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whic...
The role of NURR1 in metabolic abnormalities of Parkinson’s disease
The role of NURR1 in metabolic abnormalities of Parkinson’s disease
A constant metabolism and energy supply are crucial to all organs, particularly the brain. Age-dependent neurodegenerative...
CX3CR1 deficiency aggravates amyloid driven neuronal pathology and cognitive decline in Alzheimer’s disease
CX3CR1 deficiency aggravates amyloid driven neuronal pathology and cognitive decline in Alzheimer’s disease
Despite its identification as a key checkpoint regulator of microglial activation in Alzheimer’s disease, the overar...
Calcium-dependent cytosolic phospholipase A2 activation is implicated in neuroinflammation and oxidative stress associated with ApoE4
Calcium-dependent cytosolic phospholipase A2 activation is implicated in neuroinflammation and oxidative stress associated with ApoE4
Apolipoprotein E4 (APOE4) is associated with a greater response to neuroinflammation and the risk of developing late-onset...
Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia
Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia
A consequence of our progressively ageing global population is the increasing prevalence of worldwide age-related cognitiv...
Unraveling protein dynamics to understand the brain – the next molecular frontier
Unraveling protein dynamics to understand the brain – the next molecular frontier
The technological revolution to measure global gene expression at the single-cell level is currently transforming our know...
LILRB2-mediated TREM2 signaling inhibition suppresses microglia functions
LILRB2-mediated TREM2 signaling inhibition suppresses microglia functions
Microglia plays crucial roles in Alzheimer’s disease (AD) development. Triggering receptor expressed on myeloid cell...
Correction: Cerebrospinal fluid tau levels are associated with abnormal neuronal plasticity markers in Alzheimer’s disease
Correction: Cerebrospinal fluid tau levels are associated with abnormal neuronal plasticity markers in Alzheimer’s disease
Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, PO Box 7057 100...
Microglial lactate metabolism as a potential therapeutic target for Alzheimer’s disease
Microglial lactate metabolism as a potential therapeutic target for Alzheimer’s disease
Sierra A, Paolicelli RC, Kettenmann H. Cien Anos de microglia: milestones in a century of microglial research. Trends Neur...
Circadian clocks, cognition, and Alzheimer’s disease: synaptic mechanisms, signaling effectors, and chronotherapeutics
Circadian clocks, cognition, and Alzheimer’s disease: synaptic mechanisms, signaling effectors, and chronotherapeutics
Modulation of basic biochemical and physiological processes by the circadian timing system is now recognized as a fundamen...
BIN1 is a key regulator of proinflammatory and neurodegeneration-related activation in microglia
BIN1 is a key regulator of proinflammatory and neurodegeneration-related activation in microglia
The BIN1 locus contains the second-most significant genetic risk factor for late-onset Alzheimer’s disease. BIN1 und...
Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy
Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy
Genetic variation at the PTK2B locus encoding the protein Pyk2 influences Alzheimer’s disease risk. Neurons express ...
The role of ATP-binding cassette subfamily A in the etiology of Alzheimer’s disease
The role of ATP-binding cassette subfamily A in the etiology of Alzheimer’s disease
Alzheimer’s disease (AD) is the leading cause of dementia, clinically characterized by memory deficits and progressi...
VCP suppresses proteopathic seeding in neurons
VCP suppresses proteopathic seeding in neurons
Neuronal uptake and subsequent spread of proteopathic seeds, such as αS (alpha-synuclein), Tau, and TDP-43, contribut...
Tauopathies: new perspectives and challenges
Tauopathies: new perspectives and challenges
Tauopathies are a class of neurodegenerative disorders characterized by neuronal and/or glial tau-positive inclusions. Cli...
Cerebrospinal fluid tau levels are associated with abnormal neuronal plasticity markers in Alzheimer’s disease
Cerebrospinal fluid tau levels are associated with abnormal neuronal plasticity markers in Alzheimer’s disease
Increased total tau (t-tau) in cerebrospinal fluid (CSF) is a key characteristic of Alzheimer’s disease (AD) and is ...