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Correction: Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases
Correction: Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Looking for answers far away from the soma—the (un)known axonal functions of TDP-43, and their contribution to early NMJ disruption in ALS
Looking for answers far away from the soma—the (un)known axonal functions of TDP-43, and their contribution to early NMJ disruption in ALS
Axon degeneration and Neuromuscular Junction (NMJ) disruption are key pathologies in the fatal neurodegenerative disease A...
Correction: Synaptic dysfunction of Aldh1a1 neurons in the ventral tegmental area causes impulsive behaviors
Correction: Synaptic dysfunction of Aldh1a1 neurons in the ventral tegmental area causes impulsive behaviors
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whic...
BACE1 regulates expression of Clusterin in astrocytes for enhancing clearance of β-amyloid peptides
BACE1 regulates expression of Clusterin in astrocytes for enhancing clearance of β-amyloid peptides
Abnormal accumulation of amyloid beta peptide (Aβ) in the brain induces a cascade of pathological changes in Alzheime...
Neuropathology of incidental Lewy body & prodromal Parkinson’s disease
Neuropathology of incidental Lewy body & prodromal Parkinson’s disease
Parkinson’s disease (PD) is a progressive neurodegenerative disorder associated with a loss of dopaminergic (DA) neu...
Opinion: more mouse models and more translation needed for ALS
Opinion: more mouse models and more translation needed for ALS
Amyotrophic lateral sclerosis is a complex disorder most of which is ‘sporadic’ of unknown origin but approxim...
Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases
Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases
Autosomal dominant mutations in α-synuclein, TDP-43 and tau are thought to predispose to neurodegeneration by enhanci...
Correction: Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology
Correction: Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whic...
Leveraging the glymphatic and meningeal lymphatic systems as therapeutic strategies in Alzheimer’s disease: an updated overview of nonpharmacological therapies
Leveraging the glymphatic and meningeal lymphatic systems as therapeutic strategies in Alzheimer’s disease: an updated overview of nonpharmacological therapies
Understanding and treating Alzheimer’s disease (AD) has been a remarkable challenge for both scientists and physicia...
Carriers of the p.P522R variant in PLCγ2 have a slightly more responsive immune system
Carriers of the p.P522R variant in PLCγ2 have a slightly more responsive immune system
The rs72824905 single-nucleotide polymorphism in the PLCG2 gene, encoding the p.P522R residue change in Phospholipase C ga...
Proteostasis failure exacerbates neuronal circuit dysfunction and sleep impairments in Alzheimer’s disease
Proteostasis failure exacerbates neuronal circuit dysfunction and sleep impairments in Alzheimer’s disease
Failed proteostasis is a well-documented feature of Alzheimer’s disease, particularly, reduced protein degradation a...
NF-κB is a critical mediator of post-mitotic senescence in oligodendrocytes and subsequent white matter loss
NF-κB is a critical mediator of post-mitotic senescence in oligodendrocytes and subsequent white matter loss
Inflammaging represents an accepted concept where the immune system shifts to a low-grade chronic pro-inflammatory state w...
Targeting a vulnerable septum-hippocampus cholinergic circuit in a critical time window ameliorates tau-impaired memory consolidation
Targeting a vulnerable septum-hippocampus cholinergic circuit in a critical time window ameliorates tau-impaired memory consolidation
Abnormal tau accumulation and cholinergic degeneration are hallmark pathologies in the brains of patients with Alzheimer&#...
Using mass spectrometry to validate mouse models of tauopathy
Using mass spectrometry to validate mouse models of tauopathy
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whic...
Insights from new in vivo models of TREM2 variants
Insights from new in vivo models of TREM2 variants
Guerreiro R, Wojtas A, Bras J, Carrasquillo M, Rogaeva E, Majounie E, et al. TREM2 variants in Alzheimer’s disease. N Engl...
hiPSC-based models to decipher the contribution of human astrocytes to Alzheimer’s disease and potential therapeutics
hiPSC-based models to decipher the contribution of human astrocytes to Alzheimer’s disease and potential therapeutics
Arranz AM, De Strooper B. The role of astroglia in Alzheimer’s disease: pathophysiology and clinical implications. Lancet ...
Cerebrospinal fluid lipoproteins inhibit α-synuclein aggregation by interacting with oligomeric species in seed amplification assays
Cerebrospinal fluid lipoproteins inhibit α-synuclein aggregation by interacting with oligomeric species in seed amplification assays
Aggregation of α-synuclein (α-syn) is a prominent feature of Parkinson’s disease (PD) and other synucleino...
Plasma phospho-tau in Alzheimer’s disease: towards diagnostic and therapeutic trial applications
Plasma phospho-tau in Alzheimer’s disease: towards diagnostic and therapeutic trial applications
As the leading cause of dementia, Alzheimer's disease (AD) is a major burden on affected individuals, their families a...
Astrocytic APOE4 removal confers cerebrovascular protection despite increased cerebral amyloid angiopathy
Astrocytic APOE4 removal confers cerebrovascular protection despite increased cerebral amyloid angiopathy
Alzheimer Disease (AD) and cerebral amyloid angiopathy (CAA) are both characterized by amyloid-β (Aβ) accumulati...
The era of cryptic exons: implications for ALS-FTD
The era of cryptic exons: implications for ALS-FTD
TDP-43 is an RNA-binding protein with a crucial nuclear role in splicing, and mislocalises from the nucleus to the cytopla...
Deficits in mitochondrial TCA cycle and OXPHOS precede rod photoreceptor degeneration during chronic HIF activation
Deficits in mitochondrial TCA cycle and OXPHOS precede rod photoreceptor degeneration during chronic HIF activation
Major retinal degenerative diseases, including age-related macular degeneration, diabetic retinopathy and retinal detachme...
Correction: Anti-malaria drug artesunate prevents development of amyloid-β pathology in mice by upregulating PICALM at the blood-brain barrier
Correction: Anti-malaria drug artesunate prevents development of amyloid-β pathology in mice by upregulating PICALM at the blood-brain barrier
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whic...
A Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaques
A Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaques
The TREM2 R47H variant is one of the strongest genetic risk factors for late-onset Alzheimer’s Disease (AD). Unfortu...
The Alzheimer’s disease-linked protease BACE1 modulates neuronal IL-6 signaling through shedding of the receptor gp130
The Alzheimer’s disease-linked protease BACE1 modulates neuronal IL-6 signaling through shedding of the receptor gp130
The protease BACE1 is a major drug target for Alzheimer’s disease, but chronic BACE1 inhibition is associated with n...
Translational molecular imaging and drug development in Parkinson’s disease
Translational molecular imaging and drug development in Parkinson’s disease
Parkinson’s disease (PD) is a progressive neurodegenerative disorder that primarily affects elderly people and const...
The gut microbiome in Alzheimer’s disease: what we know and what remains to be explored
The gut microbiome in Alzheimer’s disease: what we know and what remains to be explored
Alzheimer’s disease (AD), the most common cause of dementia, results in a sustained decline in cognition. There are ...
Common mouse models of tauopathy reflect early but not late human disease
Common mouse models of tauopathy reflect early but not late human disease
Mouse models that overexpress human mutant Tau (P301S and P301L) are commonly used in preclinical studies of AlzheimerR...
Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology
Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology
The rare p.H157Y variant of TREM2 (Triggering Receptor Expressed on Myeloid Cells 2) was found to increase Alzheimer’...
In memoriam of Huaxi Xu, PhD, 1964–2022
In memoriam of Huaxi Xu, PhD, 1964–2022
Molecu...
Anti-malaria drug artesunate prevents development of amyloid-β pathology in mice by upregulating PICALM at the blood-brain barrier
Anti-malaria drug artesunate prevents development of amyloid-β pathology in mice by upregulating PICALM at the blood-brain barrier
PICALM is one of the most significant susceptibility factors for Alzheimer’s disease (AD). In humans and mice, PICAL...
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