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A perspective on Alzheimer’s disease: exploring the potential of terminal/paradoxical lucidity and psychedelics
A perspective on Alzheimer’s disease: exploring the potential of terminal/paradoxical lucidity and psychedelics
DeTure MA, Dickson DW. The neuropathological diagnosis of Alzheimer’s disease. Mol Neurodegener. 2019;14:32.Article  P...
Correction: Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia in a sex-specific manner
Correction: Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia in a sex-specific manner
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
α-Synuclein pathology disrupts mitochondrial function in dopaminergic and cholinergic neurons at-risk in Parkinson’s disease
α-Synuclein pathology disrupts mitochondrial function in dopaminergic and cholinergic neurons at-risk in Parkinson’s disease
Pathological accumulation of aggregated α-synuclein (aSYN) is a common feature of Parkinson’s disease (PD). How...
Clarifying the association of CSF Aβ, tau, BACE1, and neurogranin with AT(N) stages in Alzheimer disease
Clarifying the association of CSF Aβ, tau, BACE1, and neurogranin with AT(N) stages in Alzheimer disease
Current AT(N) stratification for Alzheimer’s disease (AD) accounts for complex combinations of amyloid (A), tau prot...
Heparin-enriched plasma proteome is significantly altered in Alzheimer’s disease
Heparin-enriched plasma proteome is significantly altered in Alzheimer’s disease
Heparin binding proteins (HBPs) with roles in extracellular matrix assembly are strongly correlated to β-amyloid (A&#...
One immune cell to bind them all: platelet contribution to neurodegenerative disease
One immune cell to bind them all: platelet contribution to neurodegenerative disease
Alzheimer’s disease (AD) and related dementias (ADRD) collectively affect a significant portion of the aging populat...
Regional desynchronization of microglial activity is associated with cognitive decline in Alzheimer’s disease
Regional desynchronization of microglial activity is associated with cognitive decline in Alzheimer’s disease
Microglial activation is one hallmark of Alzheimer disease (AD) neuropathology but the impact of the regional interplay of...
Pathological characteristics of axons and alterations of proteomic and lipidomic profiles in midbrain dopaminergic neurodegeneration induced by WDR45-deficiency
Pathological characteristics of axons and alterations of proteomic and lipidomic profiles in midbrain dopaminergic neurodegeneration induced by WDR45-deficiency
Although WD repeat domain 45 (WDR45) mutations have been linked to $$\upbeta$$ -propeller protein-associated neurodegenera...
Identification of a specific APOE transcript and functional elements associated with Alzheimer’s disease
Identification of a specific APOE transcript and functional elements associated with Alzheimer’s disease
The APOE gene is the strongest genetic risk factor for late-onset Alzheimer’s Disease (LOAD). However, the gene regu...
Network proteomics of the Lewy body dementia brain reveals presynaptic signatures distinct from Alzheimer’s disease
Network proteomics of the Lewy body dementia brain reveals presynaptic signatures distinct from Alzheimer’s disease
Lewy body dementia (LBD), a class of disorders comprising Parkinson’s disease dementia (PDD) and dementia with Lewy ...
Astrocytic autophagy plasticity modulates Aβ clearance and cognitive function in Alzheimer’s disease
Astrocytic autophagy plasticity modulates Aβ clearance and cognitive function in Alzheimer’s disease
Astrocytes, one of the most resilient cells in the brain, transform into reactive astrocytes in response to toxic proteins...
Correction: HDGFL2 cryptic proteins report presence of TDP-43 pathology in neurodegenerative diseases
Correction: HDGFL2 cryptic proteins report presence of TDP-43 pathology in neurodegenerative diseases
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Therapeutic potential of APP antisense oligonucleotides for Alzheimer’s disease and down syndrome-related Alzheimer’s disease
Therapeutic potential of APP antisense oligonucleotides for Alzheimer’s disease and down syndrome-related Alzheimer’s disease
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Astrocyte reactivity is associated with tau tangle load and cortical thinning in Alzheimer’s disease
Astrocyte reactivity is associated with tau tangle load and cortical thinning in Alzheimer’s disease
It is not fully established whether plasma β-amyloid(Aβ)42/Aβ40 and phosphorylated Tau181 (p-Tau181) can ef...
Single-cell peripheral immunoprofiling of lewy body and Parkinson’s disease in a multi-site cohort
Single-cell peripheral immunoprofiling of lewy body and Parkinson’s disease in a multi-site cohort
Multiple lines of evidence support peripheral organs in the initiation or progression of Lewy body disease (LBD), a spectr...
The interplay of inflammation and remyelination: rethinking MS treatment with a focus on oligodendrocyte progenitor cells
The interplay of inflammation and remyelination: rethinking MS treatment with a focus on oligodendrocyte progenitor cells
Multiple sclerosis (MS) therapeutic goals have traditionally been dichotomized into two distinct avenues: immune-modulator...
Anti-acetylated-tau immunotherapy is neuroprotective in tauopathy and brain injury
Anti-acetylated-tau immunotherapy is neuroprotective in tauopathy and brain injury
Tau is aberrantly acetylated in various neurodegenerative conditions, including Alzheimer’s disease, frontotemporal ...
Mis-localization of endogenous TDP-43 leads to ALS-like early-stage metabolic dysfunction and progressive motor deficits
Mis-localization of endogenous TDP-43 leads to ALS-like early-stage metabolic dysfunction and progressive motor deficits
The key pathological signature of ALS/ FTLD is the mis-localization of endogenous TDP-43 from the nucleus to the cytoplasm...
Urolithin A promotes p62-dependent lysophagy to prevent acute retinal neurodegeneration
Urolithin A promotes p62-dependent lysophagy to prevent acute retinal neurodegeneration
Age-related macular degeneration (AMD) is the leading cause of blindness in elderly people in the developed world, and the...
Fate-mapping and functional dissection reveal perilous influence of type I interferon signaling in mouse brain aging
Fate-mapping and functional dissection reveal perilous influence of type I interferon signaling in mouse brain aging
Aging significantly elevates the risk of developing neurodegenerative diseases. Neuroinflammation is a universal hallmark ...
Frontotemporal dementia-like disease progression elicited by seeded aggregation and spread of FUS
Frontotemporal dementia-like disease progression elicited by seeded aggregation and spread of FUS
RNA binding proteins have emerged as central players in the mechanisms of many neurodegenerative diseases. In particular, ...
Elevated nuclear TDP-43 induces constitutive exon skipping
Elevated nuclear TDP-43 induces constitutive exon skipping
Cytoplasmic inclusions and loss of nuclear TDP-43 are key pathological features found in several neurodegenerative disorde...
Single molecule array measures of LRRK2 kinase activity in serum link Parkinson’s disease severity to peripheral inflammation
Single molecule array measures of LRRK2 kinase activity in serum link Parkinson’s disease severity to peripheral inflammation
LRRK2-targeting therapeutics that inhibit LRRK2 kinase activity have advanced to clinical trials in idiopathic Parkinson&#...
Single-domain antibody-based protein degrader for synucleinopathies
Single-domain antibody-based protein degrader for synucleinopathies
Synucleinopathies are a group of neurodegenerative diseases characterized by the accumulation of α-synuclein (α-...
Unraveling the complex role of MAPT-containing H1 and H2 haplotypes in neurodegenerative diseases
Unraveling the complex role of MAPT-containing H1 and H2 haplotypes in neurodegenerative diseases
A ~ 1 Mb inversion polymorphism exists within the 17q21.31 locus of the human genome as direct (H1) a...
Alzheimer’s disease associated isoforms of human CD33 distinctively modulate microglial cell responses in 5XFAD mice
Alzheimer’s disease associated isoforms of human CD33 distinctively modulate microglial cell responses in 5XFAD mice
Microglia play diverse pathophysiological roles in Alzheimer’s disease (AD), with genetic susceptibility factors ske...
Variants in the MS4A cluster interact with soluble TREM2 expression on biomarkers of neuropathology
Variants in the MS4A cluster interact with soluble TREM2 expression on biomarkers of neuropathology
Recent evidence suggests that Alzheimer’s disease (AD) genetic risk variants (rs1582763 and rs6591561) of the MS4A l...
Alzheimer blood biomarkers: practical guidelines for study design, sample collection, processing, biobanking, measurement and result reporting
Alzheimer blood biomarkers: practical guidelines for study design, sample collection, processing, biobanking, measurement and result reporting
Alzheimer’s disease (AD), the most common form of dementia, remains challenging to understand and treat des...
Correction: Synaptic and memory dysfunction induced by tau oligomers is rescued by up-regulation of the nitric oxide cascade
Correction: Synaptic and memory dysfunction induced by tau oligomers is rescued by up-regulation of the nitric oxide cascade
Erica Acquarone, Elentina K. Argyrousi and Manon van den Berg contributed equally to this work.Institute for Research on A...
Adaptive immune changes associate with clinical progression of Alzheimer’s disease
Adaptive immune changes associate with clinical progression of Alzheimer’s disease
Alzheimer’s disease (AD) is the most frequent cause of dementia. Recent evidence suggests the involvement of periphe...
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