SCI时时刷

search
+
The integrated stress response in neurodegenerative diseases
The integrated stress response in neurodegenerative diseases
The integrated stress response (ISR) is a conserved network in eukaryotic cells that mediates adaptive responses to divers...
From mechanisms to future therapy: a synopsis of isolated REM sleep behavior disorder as early synuclein-related disease
From mechanisms to future therapy: a synopsis of isolated REM sleep behavior disorder as early synuclein-related disease
Parkinson disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy are synucleinopathies, characterized b...
The transcription factor combination MEF2 and KLF7 promotes axonal sprouting in the injured spinal cord with functional improvement and regeneration-associated gene expression
The transcription factor combination MEF2 and KLF7 promotes axonal sprouting in the injured spinal cord with functional improvement and regeneration-associated gene expression
Axon regeneration after injury to the central nervous system (CNS) is limited by an inhibitory environment but also becaus...
Cellular senescence induced by cholesterol accumulation is mediated by lysosomal ABCA1 in APOE4 and AD
Cellular senescence induced by cholesterol accumulation is mediated by lysosomal ABCA1 in APOE4 and AD
Cellular senescence, a hallmark of aging, has been implicated in Alzheimer’s disease (AD) pathogenesis. Cholesterol ...
Disparate and shared transcriptomic signatures associated with cortical atrophy in genetic behavioral variant frontotemporal degeneration
Disparate and shared transcriptomic signatures associated with cortical atrophy in genetic behavioral variant frontotemporal degeneration
Cortical atrophy is a common manifestation in behavioral variant frontotemporal degeneration (bvFTD), exhibiting spatial h...
Loss of MEF2C function by enhancer mutation leads to neuronal mitochondria dysfunction and motor deficits in mice
Loss of MEF2C function by enhancer mutation leads to neuronal mitochondria dysfunction and motor deficits in mice
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the loss of both upper and lowe...
Lewy body diseases and the gut
Lewy body diseases and the gut
Gastrointestinal (GI) involvement in Lewy body diseases (LBDs) has been observed since the initial descriptions of patient...
Lipidome disruption in Alzheimer’s disease brain: detection, pathological mechanisms, and therapeutic implications
Lipidome disruption in Alzheimer’s disease brain: detection, pathological mechanisms, and therapeutic implications
Alzheimer’s disease (AD) is among the most devastating neurodegenerative disorders with limited treatment options. E...
Molecular and cellular characteristics of cerebrovascular cell types and their contribution to neurodegenerative diseases
Molecular and cellular characteristics of cerebrovascular cell types and their contribution to neurodegenerative diseases
Many diseases and disorders of the nervous system suffer from a lack of adequate therapeutics to halt or slow disease prog...
Cell-specific transcriptional signatures of vascular cells in Alzheimer’s disease: perspectives, pathways, and therapeutic directions
Cell-specific transcriptional signatures of vascular cells in Alzheimer’s disease: perspectives, pathways, and therapeutic directions
Alzheimer’s disease (AD) is a debilitating neurodegenerative disease that is marked by profound neurovascular dysfun...
Emerging targets of α-synuclein spreading in α-synucleinopathies: a review of mechanistic pathways and interventions
Emerging targets of α-synuclein spreading in α-synucleinopathies: a review of mechanistic pathways and interventions
α-Synucleinopathies constitute a spectrum of neurodegenerative disorders, including Parkinson’s disease (PD), L...
Genetic context modulates aging and degeneration in the murine retina
Genetic context modulates aging and degeneration in the murine retina
Age is the principal risk factor for neurodegeneration in both the retina and brain. The retina and brain share many biolo...
APOE Christchurch enhances a disease-associated microglial response to plaque but suppresses response to tau pathology
APOE Christchurch enhances a disease-associated microglial response to plaque but suppresses response to tau pathology
Apolipoprotein E ε4 (APOE4) is the strongest genetic risk factor for late-onset Alzheimer’s disease (LOAD). A r...
Chitinase-3-like-1: a multifaceted player in neuroinflammation and degenerative pathologies with therapeutic implications
Chitinase-3-like-1: a multifaceted player in neuroinflammation and degenerative pathologies with therapeutic implications
Chitinase-3-like-1 (CHI3L1) is an evolutionarily conserved protein involved in key biological processes, including tissue ...
SIRT2 and ALDH1A1 as critical enzymes for astrocytic GABA production in Alzheimer’s disease
SIRT2 and ALDH1A1 as critical enzymes for astrocytic GABA production in Alzheimer’s disease
Alzheimer’s Disease (AD) is a neurodegenerative disease with drastically altered astrocytic metabolism. Astrocytic G...
Upregulated astrocyte HDAC7 induces Alzheimer-like tau pathologies via deacetylating transcription factor-EB and inhibiting lysosome biogenesis
Upregulated astrocyte HDAC7 induces Alzheimer-like tau pathologies via deacetylating transcription factor-EB and inhibiting lysosome biogenesis
Astrocytes, the most abundant glial cell type in the brain, will convert into the reactive state in response to proteotoxi...
RNA-Targeting CRISPR/CasRx system relieves disease symptoms in Huntington’s disease models
RNA-Targeting CRISPR/CasRx system relieves disease symptoms in Huntington’s disease models
HD is a devastating neurodegenerative disorder caused by the expansion of CAG repeats in the HTT. Silencing the expression...
Biophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple Alzheimer’s disease ligands
Biophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple Alzheimer’s disease ligands
TREM2 is a signaling receptor expressed on microglia that has emerged as an important drug target for Alzheimer’s di...
VCP regulates early tau seed amplification via specific cofactors
VCP regulates early tau seed amplification via specific cofactors
Neurodegenerative tauopathies may progress based on seeding by pathological tau assemblies, whereby an aggregate is releas...
Positron emission tomography tracers for synucleinopathies
Positron emission tomography tracers for synucleinopathies
Synucleinopathies, such as Parkinson’s disease, dementia with Lewy bodies, and multiple system atrophy, are characte...
Distinct regulation of Tau Monomer and aggregate uptake and intracellular accumulation in human neurons
Distinct regulation of Tau Monomer and aggregate uptake and intracellular accumulation in human neurons
The prion-like spreading of Tau pathology is the leading cause of disease progression in various tauopathies. A critical s...
Targeted long-read sequencing to quantify methylation of the C9orf72 repeat expansion
Targeted long-read sequencing to quantify methylation of the C9orf72 repeat expansion
The gene C9orf72 harbors a non-coding hexanucleotide repeat expansion known to cause amyotrophic lateral sclerosis and fro...
The UFMylation pathway is impaired in Alzheimer’s disease
The UFMylation pathway is impaired in Alzheimer’s disease
Alzheimer’s disease (AD) is characterized by the presence of neurofibrillary tangles made of hyperphosphorylated tau...
Mystery of gamma wave stimulation in brain disorders
Mystery of gamma wave stimulation in brain disorders
Neuronal oscillations refer to rhythmic and periodic fluctuations of electrical activity in the central nervous system tha...
Microglial CD2AP deficiency exerts protection in an Alzheimer’s disease model of amyloidosis
Microglial CD2AP deficiency exerts protection in an Alzheimer’s disease model of amyloidosis
The CD2-associated protein (CD2AP) was initially identified in peripheral immune cells and regulates cytoskeleton and prot...
Dementia with lewy bodies patients with high tau levels display unique proteome profiles
Dementia with lewy bodies patients with high tau levels display unique proteome profiles
Clinical studies have long observed that neurodegenerative disorders display a range of symptoms and pathological features...
Aging-associated sensory decline and Alzheimer’s disease
Aging-associated sensory decline and Alzheimer’s disease
Multisensory decline is common as people age, and aging is the primary risk of Alzheimer’s Disease (AD). Recent stud...
NOTCH2NLC GGC intermediate repeat with serine induces hypermyelination and early Parkinson’s disease-like phenotypes in mice
NOTCH2NLC GGC intermediate repeat with serine induces hypermyelination and early Parkinson’s disease-like phenotypes in mice
The expansion of GGC repeats (typically exceeding 60 repeats) in the 5’ untranslated region (UTR) of the NOTCH2NLC g...
Seeding activity of skin misfolded tau as a biomarker for tauopathies
Seeding activity of skin misfolded tau as a biomarker for tauopathies
Tauopathies are a group of age-related neurodegenerative diseases characterized by the accumulation of pathologically hype...
Human VCP mutant ALS/FTD microglia display immune and lysosomal phenotypes independently of GPNMB
Human VCP mutant ALS/FTD microglia display immune and lysosomal phenotypes independently of GPNMB
Microglia play crucial roles in maintaining neuronal homeostasis but have been implicated in contributing to amyotrophic l...
阅读更多
format_indent_increase