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Identifying immunohistochemical biomarkers panel for non-small cell lung cancer in optimizing treatment and forecasting efficacy
Identifying immunohistochemical biomarkers panel for non-small cell lung cancer in optimizing treatment and forecasting efficacy
Chemotherapy and immunotherapy for non-small-cell lung cancer (NSCLC) are gaining momentum. However, its long-term efficac...
Clinicopathologic features and treatment efficacy of patients with BRAF V600E-mutated metastatic colorectal cancer: a multi-center real-world propensity score matching study
Clinicopathologic features and treatment efficacy of patients with BRAF V600E-mutated metastatic colorectal cancer: a multi-center real-world propensity score matching study
Patients with BRAF 600E mutated mCRC are associated with specific clinicopathological features and poor prognosis. The rel...
Integrating 18F-FDG PET/CT radiomics and body composition for enhanced prognostic assessment in patients with esophageal cancer
Integrating 18F-FDG PET/CT radiomics and body composition for enhanced prognostic assessment in patients with esophageal cancer
This study aimed to develop a predictive model utilizing radiomics and body composition features derived from 18F-FDG PET/...
Interim analysis of the multinational, post-authorization safety study (NISSO) to assess the long-term safety of sonidegib in patients with locally advanced basal cell carcinoma
Interim analysis of the multinational, post-authorization safety study (NISSO) to assess the long-term safety of sonidegib in patients with locally advanced basal cell carcinoma
Following the pivotal phase II trial BOLT, the Hedgehog (Hh) inhibitor sonidegib was approved in the EU to treat locally a...
A new tumor-treating device OM-100 with low-frequency magnetic fields inhibits proliferation and metastasis in liver cancer
A new tumor-treating device OM-100 with low-frequency magnetic fields inhibits proliferation and metastasis in liver cancer
This study aims to investigate a novel instrument OM-100 with low-frequency magnetic fields (LFMFs) for its potential appl...
Prognostic value of FDX1, the cuprotosis key gene, and its prediction models across imaging modalities and histology
Prognostic value of FDX1, the cuprotosis key gene, and its prediction models across imaging modalities and histology
Cuprotosis has been identified as a novel way of cell death. The key regulator ferredoxin 1 (FDX1) was explored via pan-ca...
Second primary cancers in patients with a pharyngeal index tumour: a register-based cohort study
Second primary cancers in patients with a pharyngeal index tumour: a register-based cohort study
While prior research on the SPC (second primary cancer) risk among pharyngeal carcinoma (PC) patients has been conducted i...
Study protocol of an exercise and nutrition intervention for ovarian cancer patients during and after first-line chemotherapy (BENITA) - a randomized controlled trial
Study protocol of an exercise and nutrition intervention for ovarian cancer patients during and after first-line chemotherapy (BENITA) - a randomized controlled trial
In ovarian cancer frequently reported side effects are muscle wasting and malnutrition, leading to frailty, decreased heal...
Recurrent aphthous stomatitis and neoplasms of the mouth and pharynx: a two-sample Mendelian randomization study
Recurrent aphthous stomatitis and neoplasms of the mouth and pharynx: a two-sample Mendelian randomization study
The association between recurrent aphthous stomatitis (RAS) and neoplasms of the mouth and pharynx (NOMAP) has been report...
DPYD genotype-guided dose personalisation for fluoropyrimidine-based chemotherapy prescribing in solid organ cancer patients in Australia: GeneScreen 5-FU study protocol
DPYD genotype-guided dose personalisation for fluoropyrimidine-based chemotherapy prescribing in solid organ cancer patients in Australia: GeneScreen 5-FU study protocol
Fluoropyrimidine (FP) chemotherapies are commonly prescribed for upper and lower gastrointestinal, breast and head and nec...
Cervical precancer screening using self-sampling, HPV DNA testing, and mobile colposcopy in a hard-to-reach community in Ghana: a pilot study
Cervical precancer screening using self-sampling, HPV DNA testing, and mobile colposcopy in a hard-to-reach community in Ghana: a pilot study
The World Health Organization has set ambitious goals to eliminate cervical cancer, necessitating evidence on increasing c...
Determining optimal clinical target volume margins based on microscopic extracapsular extension of metastatic nodes in patients with non-small-cell lung cancer after chemotherapy or chemotherapy combined with immunotherapy
Determining optimal clinical target volume margins based on microscopic extracapsular extension of metastatic nodes in patients with non-small-cell lung cancer after chemotherapy or chemotherapy combined with immunotherapy
No standard has been established for the clinical target volume (CTV) margins of lymph nodes (LNs) in patients with non-sm...
Neoadjuvant immune checkpoint inhibitor reduced recurrence in operable NSCLC patients with pathological complete response: a retrospective analysis
Neoadjuvant immune checkpoint inhibitor reduced recurrence in operable NSCLC patients with pathological complete response: a retrospective analysis
This study aimed to evaluate if neoadjuvant immune checkpoint inhibitor (ICI) plus chemotherapy (CT) reduced tumor recurre...
Predicting radiation pneumonitis in lung cancer using machine learning and multimodal features: a systematic review and meta-analysis of diagnostic accuracy
Predicting radiation pneumonitis in lung cancer using machine learning and multimodal features: a systematic review and meta-analysis of diagnostic accuracy
To evaluate the diagnostic accuracy of machine learning models incorporating multimodal features for predicting radiation ...
Investigating the role of non-synonymous variant D67N of ADGRE2 in chronic myeloid leukemia
Investigating the role of non-synonymous variant D67N of ADGRE2 in chronic myeloid leukemia
Chronic myeloid leukaemia (CML) is a type of blood cancer that begins in the hematopoietic stem cells. It is primarily cha...
Mesenchymal stem cell-derived exosomes carrying miR-486-5p inhibit glycolysis and cell stemness in colorectal cancer by targeting NEK2
Mesenchymal stem cell-derived exosomes carrying miR-486-5p inhibit glycolysis and cell stemness in colorectal cancer by targeting NEK2
Colorectal cancer (CRC) is a major global concern. Mesenchymal stem cell-derived exosomes (MSC-EXOs) have demonstrated eff...
The optimal timing of breast cancer surgery after COVID-19 infection: an observational study
The optimal timing of breast cancer surgery after COVID-19 infection: an observational study
It is controversial for the optimal time of breast cancer surgery after COVID-19 infection. Purpose was to assess the risk...
Efficacy and toxicity of lurbinectedin in subsequent systemic therapy of extensive-stage small cell lung cancer: a meta-analysis
Efficacy and toxicity of lurbinectedin in subsequent systemic therapy of extensive-stage small cell lung cancer: a meta-analysis
This study aimed to systematically analyze the efficacy and toxicity of lurbinectedin as a second-line or subsequent treat...
Sentinel lymph node biopsy in cT1-2N0 minor salivary gland cancer in oral cavity
Sentinel lymph node biopsy in cT1-2N0 minor salivary gland cancer in oral cavity
To evaluate the efficacy of sentinel lymph node biopsy (SLNB) in cT1/2N0 minor salivary gland cancer (mSGC) located within...
Osteosarcoma cells depend on MCL-1 for survival, and osteosarcoma metastases respond to MCL-1 antagonism plus regorafenib in vivo
Osteosarcoma cells depend on MCL-1 for survival, and osteosarcoma metastases respond to MCL-1 antagonism plus regorafenib in vivo
Osteosarcoma is the most common form of primary bone cancer, which primarily afflicts children and adolescents. Chemothera...
Integrating clinical and image-based parameters for prediction of early post-prostatectomy incontinence recovery: simplified nomogram approach
Integrating clinical and image-based parameters for prediction of early post-prostatectomy incontinence recovery: simplified nomogram approach
This study aimed to develop a novel model that combines both clinical and image-based parameters to predict early recovery...
In-depth analysis and trends of cancer mortality in Kazakhstan: a joinpoint analysis of nationwide healthcare data 2014–2022
In-depth analysis and trends of cancer mortality in Kazakhstan: a joinpoint analysis of nationwide healthcare data 2014–2022
Cancer remains a leading cause of death both globally and in Kazakhstan, making it crucial to track its mortality trends. ...
Integrated bulk and single-cell profiling characterize sphingolipid metabolism in pancreatic cancer
Integrated bulk and single-cell profiling characterize sphingolipid metabolism in pancreatic cancer
Abnormal sphingolipid metabolism (SM) is closely linked to the incidence of cancers. However, the role of SM in pancreatic...
Cancer care treatment attrition in adults: Measurement approaches and inequities in patient dropout rates – a rapid review
Cancer care treatment attrition in adults: Measurement approaches and inequities in patient dropout rates – a rapid review
Cancer treatment attrition refers to the discontinuation of prescribed cancer therapies before completion. It can signific...
Establishment and validation of a population pharmacokinetic model for apatinib in patients with tumors
Establishment and validation of a population pharmacokinetic model for apatinib in patients with tumors
This study aimed to develop a population pharmacokinetic (PPK) model for oral apatinib in Chinese oncology patients and in...
Integration of bioinformatics and cellular experiments unveils the role of SYT12 in gastric cancer
Integration of bioinformatics and cellular experiments unveils the role of SYT12 in gastric cancer
This study employs integrated bioinformatics analysis and in vitro cellular experiments to elucidate the role of Synaptota...
Potential of PSMA for breast cancer in nuclear medicine: digital quantitative immunohistochemical analysis and implications for a theranostic approach
Potential of PSMA for breast cancer in nuclear medicine: digital quantitative immunohistochemical analysis and implications for a theranostic approach
Further research is still needed to fully understand the potential of prostate-specific membrane antigen (PSMA) in breast ...
A narrative review: exploring viral-induced malignancies through the lens of dysregulated cellular metabolism and glucose transporters
A narrative review: exploring viral-induced malignancies through the lens of dysregulated cellular metabolism and glucose transporters
In this narrative review, we unravel the complex interplay between oncogenic viruses, cellular metabolism, and glucose tra...
VASN promotes the aggressive phenotype in ARID1A-deficient lung adenocarcinoma
VASN promotes the aggressive phenotype in ARID1A-deficient lung adenocarcinoma
Loss of ARID1A has been reported to drive the progression of lung adenocarcinoma, yet the underlying mechanism remains elu...
First-line treatment with gefitinib in combination with bevacizumab and chemotherapy in advanced non-squamous NSCLC with EGFR-mutation
First-line treatment with gefitinib in combination with bevacizumab and chemotherapy in advanced non-squamous NSCLC with EGFR-mutation
The safety and efficacy of combination of gefitinib with chemotherapy and bevacizumab in treatment patients with epidermal...
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