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Commentary on ‘tools for optimizing pharmacotherapy in psychiatry (therapeutic drug monitoring, molecular brain imaging and pharmacogenetic tests): focus on antidepressants’
*Author for correspondence: Tel.: +859 246 8440; E-mail Address: jdeleon@uky.eduhttps://orcid.org/0000-0002-7756-2314Menta...
Resistance to platinum-based cancer drugs: a special focus on epigenetic mechanisms
Chemoresistance is a significant clinical challenge, limiting the drug response in cancer. Several mechanisms associated w...
Tabula Rasa HealthCare company profile: involvement on pharmacogenomic and personalized medicine research
A Matos, P Dow, JM Bingham, V Michaud, CH Knowlton and J Turgeon are employees and shareholders of TRHC. LJ Lesko is Chair...
Is there a benefit for CYP2C19 genotype-guided antiplatelet treatment in elderly acute coronary syndrome patients?
JM ten Berg reports grants from the Netherlands Organization for Health Research and Development, a Dutch government insti...
The role of SLCO1B1 genotyping in lowering cardiovascular risk
https://orcid.org/0000-0001-6113-5564Section of General Internal Medicine, Veterans Affairs Boston Healthcare System, Bost...
Resolving discordant CYP2D6 genotyping results in Thai subjects: platform limitations and novel haplotypes
Aim: Several CYP2D6 Luminex xTAG genotype calls were identified as inconsistent or suspicious among Thai subjects and furt...
Efficacy and safety of opioid therapy guided by pharmacogenetics: a systematic review
Aim: To perform a systematic review to determine the efficacy/safety of PGx-guided opioid therapy for chronic/postoperativ...
Inaugural Pharmacogenomics Access and Reimbursement Symposium
The Pharmacogenomics Access & Reimbursement Symposium, a landmark event presented by the Golden Helix Foundation and t...
Pharmacogenomics education, research and clinical implementation in the state of Minnesota
Several healthcare organizations across Minnesota have developed formal pharmacogenomic (PGx) clinical programs to increas...
Pharmacogenomic landscape of COVID-19 therapies from Indian population genomes
Aim: Numerous drugs are being widely prescribed for COVID-19 treatment without any direct evidence for the drug safety/eff...
KRAS-targeted therapies in advanced solid cancers: drug the undruggable?
The authors have no relevant affiliations or financial involvement with any organization or entity with a financial intere...
Resolving discordant CYP2D6 genotyping results in Thai: platform limitations and novel haplotypes
Aim: Several CYP2D6 Luminex xTAG genotype calls were identified as inconsistent or suspicious among Thai subjects and furt...
Implementation of a next-generation sequencing-based targeted approach for full-length CYP3A4 gene sequencing
Aim: To evaluate the application of next-generation sequencing-based targeted protocol for full-length CYP3A4 gene sequenc...
Efficacy and safety of opioid therapy guided by pharmacogenetics (PGx): a systematic review
Aim: To perform a systematic review to determine the efficacy/safety of PGx-guided opioid therapy for chronic/postoperativ...
Therapy response prediction in major depressive disorder: current and novel genomic markers influencing pharmacokinetics and pharmacodynamics
Major depressive disorder is connected with high rates of functional disability and mortality. About a third of the patien...
Conference report: inaugural Pharmacogenomics Access and Reimbursement Symposium
The Pharmacogenomics Access & Reimbursement Symposium, a landmark event presented by the Golden Helix Foundation and t...
The need for a refined understanding of CYP2D6 in second-generation antipsychotic outcomes in children and adolescents
Tweetable abstract High-quality studies examining the influence of CYP2D6 on the exposure and tolerability of antipsychoti...
Evolution and functional divergence of the ERBB receptor family
Aim: The ERBB gene family plays an important role in cell proliferation and differentiation, and aberrant activations coul...
Extending the lymphoblastoid cell line model for drug combination pharmacogenomics
Combination drug therapies have become an integral part of precision oncology, and while evidence of clinical effectivenes...
Are there monogenic hereditary forms of bladder cancer or only genetic susceptibilities?
Bladder cancer (BC) is the most common cancer involving the urinary system and the ninth most common cancer worldwide. Tob...
A meta-analysis of effects of CYP2C9 and CYP2C19 polymorphisms on phenytoin pharmacokinetic parameters
Aim: Phenytoin is metabolized through CYP2C9 and CYP2C19. Polymorphisms of CYP2C9 and CYP2C19 may increase plasma concentr...
Genetic variants of PEAR1 and ischemic clinical outcomes in coronary artery disease patients: a systematic review and meta-analysis
Aim: The aim of this study was to assess the association between PEAR1 polymorphisms and ischemic clinical outcomes. Mater...
Gender-dependent association of TYMS-TSER polymorphism with 5-fluorouracil or capecitabine based chemotherapy toxicity
Aim: TYMS gene encodes for TS enzyme involved in 5-fluorouracil (5-FU) and capecitabine (CAP) metabolism. This study asses...
Novel associations between CYP2B6 polymorphisms, perioperative methadone metabolism and clinical outcomes in children
Aim: Methadone exhibits significant variability in clinical response. This study explores the genetic influence of variabl...
Application of the community dialogues method to identify ethical values and priorities related to pharmacogenomics
Given the expansion of genetics in medicine, there is a growing need to develop approaches to engage patients in understan...
Harnessing biomarkers of response to improve therapy selection in esophago-gastric adenocarcinoma
Advanced esophago-gastric (OG) adenocarcinomas have a high mortality rate and new therapeutic options are urgently require...
Efficacy and safety of statins in ethnic differences: a lesson for application in Indigenous Australian patient care
Although statins are effective in treating high cholesterol, adverse effects do occur with their use. Efficacy and tolerab...
Role of the preoperative circulating tumor DNA KRAS mutation in patients with resectable pancreatic cancer
Aim: The prognosis of resectable pancreatic cancer patients with the same stage of disease is highly variable. The purpose...
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