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The effects of thymidylate synthase 3'UTR genotype on methylation of tumor-specific genes promoter in 22 colorectal cancer patients from southern Iran
To investigate the effects of thymidylate synthase (TS) 3'UTR genotype on promotor methylation of tumor-related genes...
Examining the expression of low-density lipoprotein receptor (LDLR) and low-density lipoprotein receptor-related protein 6 (LRP6) genes in breast cancer cell lines
Cholesterol and the Wnt/β-catenin pathway have an effective role in the proliferation, survival, drug resistance, immune e...
The role of miR-133a in silibinin-mediated inhibition of the PI3K/AKT/mTOR pathway in MCF-7 breast carcinoma cells
Breast cancer is particularly severe in women. Research highlights the crucial role of miRNAs in key cellular processes, s...
Association study of the polymorphisms rs2228611 of the DNMT1 gene and rs1569686 of the DNMT3B gene with bladder cancer development in a sample of the Algerian population
Bladder cancer (BC) is a multifactorial disease with a poorly understood main cause. In this study, we aimed to evaluate t...
Phylogenetic position inferred on SSU rDNA sequence gene and description of a new parasitic cnidarian (Endocnidozoa: Myxobolidae) infecting Markiana nigripinnis (Teleostei: Stevardiinae) from a small marginal lake floodplain, Brazil
Herein, a detailed molecular phylogeny analysis was developed to determine the phylogenetic position of a new freshwater h...
Hijacking the epigenetic mechanisms of A. baumannii
Epigenetic mechanisms attribute to the resistance and virulence of Acinetobacter baumannii sparking a renewed area of rese...
Allele and genotype frequencies of β-lactoglobulin gene using PCR-RFLP in Algerian local cattle populations
Milk protein genetic polymorphisms are associated with economically important traits in dairy cattle. The objective of thi...
In-silico structural analysis of Heterocephalus glaber amyloid beta: an anti-Alzheimer's peptide
Heterocephalus glaber, known as the Naked mole-rat, has an extraordinary immunity to Alzheimer's disease. The patholo...
MicroRNAs targeting CDKN2A gene as a potential prognostic marker in head and neck squamous cell carcinoma
Epigenetic factors are known to markedly influence the functions of a gene by modification of transcripts, via methylation...
Evaluation of Beclin1 and mTOR genes and p62 protein expression in breast tumor tissues of Iranian patients
Autophagy is a cellular process that plays a major role in the fate of tumor cells. Understanding the role of autophagy in...
Arginine to glutamine mutation in the substrate binding region impaired the isopentenyl activity of Mycobacterium tuberculosis MiaA
tRNAs act as adaptors during protein synthesis and are chemically modified post-transcriptionally for their structural sta...
The importance of examining the Hardy-Weinberg Equilibrium in genetic association studies
No abstract
A comparison of phylogenetic and distance-based approaches for the distinction of genetically closed species, Draba rimarum (Rech.f.) A.R. Khosravi & A. Eslami-Farouji, and Draba aucheri Boiss. (Brassicaceae) as a case study
Circumscribing species boundries is necessary in systematic plant biology. Even a mistake in delimiting taxa may lead to i...
Human BKV large T genome detection in prostate cancer and benign prostatic hyperplasia tissue samples by nested PCR: A case-control study
Human BK polyomavirus (BKPyV) is a latent infectious agent in the genitourinary tract associated with hemorrhagic cystitis...
Сytotoxic effect of CAR-T cells against modified MCF-7 breast cancer cell line
The most often diagnosed and fatal malignancy in women is breast cancer. The International Agency for Research on Cancer (...
Genetic association between rs1695 in glutathione S-transferase P1 and risk of periodontitis: a pilot study
The present study aims to determine the association between a genetic polymorphism of GSTP1 (rs1695) and the risk of perio...
Evaluating the association of rs6983267 polymorphism of the CCAT2 gene with thyroid cancer susceptibility in the Iranian Azeri population
Thyroid cancer is the most common malignancy of the endocrine system. LncRNAs play critical role in various cellular proce...
Using several pseudo amino acid composition types and different machine learning algorithms to classify and predict archaeal phospholipases
Phospholipases, as important lipolytic enzymes, have diverse industrial applications. Regarding the stability of extremoph...
The effect of RORA (RAR-Related Orphan Receptor Alpha) receptors on litter size in Akkaraman sheep breed
In this study, the relationship between RORA 23bp indel genotype and allele frequency with twin pregnancy, fertility, live...
Structural arrangement of the active back-to-back dimer in N-glycosylated ErbB receptors is regulated by heterodimerization
The human epidermal growth factor receptor (EGFR/ErbB) family consists of four members (ErbB1-4) and belongs to the superf...
Detection of Hepatozoon spp. in dogs in Shiraz, southern Iran and its effects on the hematological alterations
Canine hepatozoonosis is a tick-transmitted apicomplexan infection caused by two species of Hepatozoon, H. canis, and H. a...
The effect of Annexin A5 overexpression on invasiveness and expression of the genes involved in epithelial-mesenchymal transition of HCT 116 cell line
Epithelial-to-mesenchymal transition (EMT) plays a critical role in colorectal cancer (CRC) metastasis. In the present stu...
Molecular mimicry and COVID-19: Potential implications for global fertility
There has been a concerning increase in the incidence of autoimmune diseases following SARS-CoV-2 infection, with molecula...
Genetic alterations in MED12 promote castration-resistant prostate cancer through modulation of GLI3 signaling
Prostate cancer is a disease that depends on androgenic stimulation and is thus commonly treated with androgen deprivation...
Association between CX3CR1 rs3732378 polymorphism and neovascular age-related macular degeneration in a sample of Algerian population
Neovascular age-related macular degeneration (nAMD) is a progressive ocular disease, responsible for central visual loss a...
The genetic polymorphisms at the promoter region of HLA-DQB1 gene, creating responsive elements for NF1/CTF and converting the TFII-D binding site to GR-alpha
Human leukocyte antigen-DQB1 (HLA-DQB1, OMIM: 604305) is the human major histocompatibility complex (MHC) system. HLA gene...
Toxicity and autophagy effects of fluorinated cycloplatinated(II) complex bearing dppm ligand on cancer cells in in-vitro culture and in-silico prediction
Toxicity and autophagy effects of a new complex of platinum II (CPC) were evaluated on HeLa cells cultured on a PCL/gelati...
Design and construction of a chimeric peptide, MeICT/IMe-AGAP, from two anti-cancer toxins of Iranian Mesobuthus eupeus scorpion
Scorpion venom contains various toxin peptides with pharmacological and biological properties. Scorpion toxins specificall...
The molecular characteristics of colorectal cancer: Impact of Ibuprofen and hyperthermia
Despite various treatment options available for colorectal cancer, the survival rates for patients remain low. This study ...
Comparison of five DNA extraction methods in three medicinal plants: Peganum harmala L., Tamarix ramosissima Ledeb., and Potentilla reptans L.
Extracting high-yield, high-quality DNA from plant samples is challenging due to the presence of the cell wall, pigments, ...
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