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CRLF2 expression associated with poor outcome in Philadelphia-negative acute lymphoblastic leukemia
CRLF2 expression associated with poor outcome in Philadelphia-negative acute lymphoblastic leukemia
Adult Philadelphia (Ph)-negative B‑acute lymphoblastic leukemia (Ph-ALL) patients often exhibit elevated levels of C...
Evolving treatment paradigms after CDK4/6 inhibitors in advanced breast cancer
Evolving treatment paradigms after CDK4/6 inhibitors in advanced breast cancer
Cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) have transformed the treatment of hormone-receptor-positive, human epider...
Rare case of human epidermal growth factor receptor 2-positive gastric remnant cancer after bariatric surgery—case report
Rare case of human epidermal growth factor receptor 2-positive gastric remnant cancer after bariatric surgery—case report
Parallel to the increasing number of patients with obesity and metabolic syndrome, the number of bariatric procedures is r...
JAK2 mutations in polycythemia vera: from molecular origins to inflammatory pathways and clinical implications
JAK2 mutations in polycythemia vera: from molecular origins to inflammatory pathways and clinical implications
Polycythemia vera (PV) is a myeloproliferative neoplasm primarily driven by mutations in the JAK2 gene, most notably the V...
Unraveling (K)RAS in pancreatic ductal adenocarcinoma
Unraveling (K)RAS in pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy with a poor 5‑year survival ...
Impact of the WHO-5 classification of haematolymphoid tumours on clinical practice
Impact of the WHO-5 classification of haematolymphoid tumours on clinical practice
The long-awaited 2022 World Health Organization Classification of Haematolymphoid Tumours (WHO-5-HAEM) has finally been pu...
State-of-the-art therapy and innovative treatment strategies in esophageal squamous cell cancer
State-of-the-art therapy and innovative treatment strategies in esophageal squamous cell cancer
Recent advances in the development of new therapeutic agents and the execution of numerous randomized controlled trials ha...
Implantable catheter chambers: a 14-year descriptive study
Implantable catheter chambers: a 14-year descriptive study
Implantable catheter chambers are widely used devices during the treatment of cancer whether for taking blood samples or f...
BACE (Bendamustine, Cytarabine, Cyclophosphamide and Etoposide) conditioning regime for patients with lymphoma undergoing autologous stem cell transplant
BACE (Bendamustine, Cytarabine, Cyclophosphamide and Etoposide) conditioning regime for patients with lymphoma undergoing autologous stem cell transplant
Autologous stem cell transplant (ASCT) is a curative treatment for lymphomas. BEAM conditioning (Carmustine, Etoposide, Cy...
Treatment sequencing in gastroenteropancreatic neuroendocrine tumors
Treatment sequencing in gastroenteropancreatic neuroendocrine tumors
The oncological treatment of neuroendocrine tumors (NET) has improved significantly in the last few years. Several informa...
Unclassifiable acute leukemia with blastic plasmacytoid dendritic cell neoplasm: deciding on the appropriate therapy
Unclassifiable acute leukemia with blastic plasmacytoid dendritic cell neoplasm: deciding on the appropriate therapy
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare, clinically aggressive tumor derived from the precursors of...
Importance of genetic clarification in cytopenia syndromes (childhood myelodysplastic syndrome forms)
Importance of genetic clarification in cytopenia syndromes (childhood myelodysplastic syndrome forms)
Childhood myelodysplastic syndrome (cMDS) is a rare clonal hematopoietic disorder characterized by peripheral cytopenia, w...
KRAS (Kirsten rat sarcoma) in modern oncology—The molecular pathological point of view
KRAS (Kirsten rat sarcoma) in modern oncology—The molecular pathological point of view
The Rat sarcoma protein (RAS) was the first proto-oncogene to be discovered and is one of the best researched tumor driver...
Importance of allogeneic stem cell transplantation in myelofibrosis
Importance of allogeneic stem cell transplantation in myelofibrosis
Allogeneic stem cell transplantation (alloSCT) is the only curative treatment option for patients with high-risk myelofibr...
Novel mutated Dubin–Johnson syndrome diagnosed during acute promyelocytic leukemia treatment
Novel mutated Dubin–Johnson syndrome diagnosed during acute promyelocytic leukemia treatment
Coexistence of acute promyelocytic leukemia and Dubin–Johnson syndrome (DJS) has not been previously reported in the...
GATA2 deficiency: a mystery myelodysplasia
GATA2 deficiency: a mystery myelodysplasia
GATA2 deficiency, arising from mutations in the GATA2 gene, is a rare genetic disorder with profound implications...
Liquid profiling for patients with advanced cancer is ready for clinical integration
Liquid profiling for patients with advanced cancer is ready for clinical integration
Molecular profiling of circulating tumor DNA (ctDNA) to guide treatment decisions has found its way into routine managemen...
Antibody–drug conjugates in the treatment of lymphoid neoplasms
Antibody–drug conjugates in the treatment of lymphoid neoplasms
Antibody-drug conjugates (ADCs) are a new class of monoclonal antibodies with the characteritic to specifically target tum...
NEC versus NET G3—is there a grey zone? Case report of pancreatic NET G3 with rapid disease progression
NEC versus NET G3—is there a grey zone? Case report of pancreatic NET G3 with rapid disease progression
Patients with well-differentiated neuroendocrine tumors of grade 3 (NET G3) exhibit a significa...
Alternating chemotherapy with VDC-IE as effective first-line treatment in a patient with SMARCA4-deficient undifferentiated tumor
Alternating chemotherapy with VDC-IE as effective first-line treatment in a patient with SMARCA4-deficient undifferentiated tumor
SMARCA4-deficient undifferentiated tumor (SMARCA4-UTs) is an extremely rare and aggressive entity where no consensus on sy...
American Society of Hematology (ASH) update 2023—chronic lymphocytic leukemia
American Society of Hematology (ASH) update 2023—chronic lymphocytic leukemia
In recent years, there has been massive advances in the treatment of chronic lymphocytic leukemia (CLL) from chemoimmunoth...
Prediction of epidermal growth factor receptor mutation status by textural features in stage IV lung adenocarcinoma
Prediction of epidermal growth factor receptor mutation status by textural features in stage IV lung adenocarcinoma
The purpose of this study was to assess the correlation between textural features from 18fluorodeoxyglucose positron emiss...
Seminal vesicle metastasis from transverse colon adenocarcinoma: a unique case report
Seminal vesicle metastasis from transverse colon adenocarcinoma: a unique case report
Seminal vesicle metastasis from colon adenocarcinoma is very rare, with only two case reports in the literature. Also, pos...
β-adrenergic modulation of IL-6/gp130 and SOCS-1 in multiple myeloma: therapeutic strategy for stress induced-inflammatory response
β-adrenergic modulation of IL-6/gp130 and SOCS-1 in multiple myeloma: therapeutic strategy for stress induced-inflammatory response
Multiple Myeloma (MM) is considered an incurable, biologically heterogeneous disease of the plasma cells. The clinical dat...
Innovative therapeutic concepts for biliary tumors
Innovative therapeutic concepts for biliary tumors
In recent years there have been significant changes in the treatment of bile duct carcinoma. Immunotherapy has been includ...
Acute myeloid leukemia patient with active disseminated tuberculosis bridged to transplant with reduced 14-day venetoclax and azacitidine schedule
Acute myeloid leukemia patient with active disseminated tuberculosis bridged to transplant with reduced 14-day venetoclax and azacitidine schedule
A 59-year-old female patient was diagnosed with acute myeloid leukemia and tuberculosis. As a further co...
(Neo)adjuvant approaches in lung cancer—paving the road to a cure
(Neo)adjuvant approaches in lung cancer—paving the road to a cure
Immune checkpoint inhibitors (ICI) have revolutionized the treatment landscape of metastatic non-small-cell lung cancer (N...
Evidence and emerging trends in local therapy for metastatic hormone-sensitive prostate cancer: a narrative review
Evidence and emerging trends in local therapy for metastatic hormone-sensitive prostate cancer: a narrative review
Metastatic hormone-sensitive prostate cancer (mHSPC) displays both simultaneous and sequential patterns of metastasis, emp...
Total neoadjuvant therapy for each locally advanced rectal cancer?
Total neoadjuvant therapy for each locally advanced rectal cancer?
The treatment paradigm for locally advanced rectal cancer has changed in recent years. Neoadjuvant radiochemotherapy follo...
Pulmonary puzzles: salivary gland-type tumors of the lung and their metastatic equivalents
Pulmonary puzzles: salivary gland-type tumors of the lung and their metastatic equivalents
In the last decade, the understanding of lung neoplasms, particularly rare salivary gland-type tumors (SGT), has deepened ...
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