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Representative measles virus infection requires appropriate airway epithelia culture conditions
Representative measles virus infection requires appropriate airway epithelia culture conditions
ABSTRACT Despite an effective vaccine, measles virus (MeV) remains a critical health burden worldwide. Many fundamental qu...
Genetic engineering strategy for generating a stable dsRNA virus vector using a virus-like codon-modified transgene
Genetic engineering strategy for generating a stable dsRNA virus vector using a virus-like codon-modified transgene
ABSTRACT Deletion or truncation of transgenes encoded in RNA virus vectors frequently occur. Genetic instability of transg...
Zika virus infection leads to hormone deficiencies of the hypothalamic-pituitary-gonadal axis and diminished fertility in mice
Zika virus infection leads to hormone deficiencies of the hypothalamic-pituitary-gonadal axis and diminished fertility in mice
ABSTRACT Zika virus (ZIKV) infection in pregnant women during the first trimester can cause congenital malformations inclu...
Identification of tanshinone I as cap-dependent endonuclease inhibitor with broad-spectrum antiviral effect
Identification of tanshinone I as cap-dependent endonuclease inhibitor with broad-spectrum antiviral effect
ABSTRACT The cap-snatching mechanism mediated by cap-dependent endonuclease, which is common among the negative-stranded, ...
Genetic signatures associated with the virulence of porcine epidemic diarrhea virus AH2012/12
Genetic signatures associated with the virulence of porcine epidemic diarrhea virus AH2012/12
ABSTRACT Porcine epidemic diarrhea virus (PEDV) is a highly pathogenic swine coronavirus causing severe diarrhea and high ...
Micropterus salmoides rhabdovirus enters cells via clathrin-mediated endocytosis pathway in a pH-, dynamin-, microtubule-, rab5-, and rab7-dependent manner
Micropterus salmoides rhabdovirus enters cells via clathrin-mediated endocytosis pathway in a pH-, dynamin-, microtubule-, rab5-, and rab7-dependent manner
ABSTRACT Micropterus salmoides rhabdovirus (MSRV) is an important fish pathogen that infects largemouth bass. To date, the...
Constitutive proteins of lumpy skin disease virion assessed by next-generation proteomics
Constitutive proteins of lumpy skin disease virion assessed by next-generation proteomics
ABSTRACT Lumpy skin disease (LSD) virus, a ruminant poxvirus of the Capripoxvirus genus, is the etiologic agent of an econ...
Vaccination with prefusion-stabilized respiratory syncytial virus fusion protein elicits antibodies targeting a membrane-proximal epitope
Vaccination with prefusion-stabilized respiratory syncytial virus fusion protein elicits antibodies targeting a membrane-proximal epitope
ABSTRACT Respiratory syncytial virus (RSV) causes tens of millions of acute lower respiratory tract infections and million...
Characterization of integrated Marek’s disease virus genomes supports a model of integration by homology-directed recombination and telomere-loop-driven excision
Characterization of integrated Marek’s disease virus genomes supports a model of integration by homology-directed recombination and telomere-loop-driven excision
ABSTRACT Marek’s disease virus (MDV) is a lymphotropic alphaherpesvirus that readily infects chickens and some other poult...
The D129L protein of African swine fever virus interferes with the binding of transcriptional coactivator p300 and IRF3 to prevent beta interferon induction
The D129L protein of African swine fever virus interferes with the binding of transcriptional coactivator p300 and IRF3 to prevent beta interferon induction
ABSTRACT African swine fever virus (ASFV) is a large and complex DNA virus that causes a highly lethal swine disease, agai...
Determination of the factors responsible for the tropism of SARS-CoV-2-related bat coronaviruses to Rhinolophus bat ACE2
Determination of the factors responsible for the tropism of SARS-CoV-2-related bat coronaviruses to Rhinolophus bat ACE2
ABSTRACT Differences in host angiotensin converting enzyme 2 (ACE2) genes may affect the host range of SARS-CoV-2-related ...
Functional comparisons of the virus sensor RIG-I from humans, the microbat Myotis daubentonii, and the megabat Rousettus aegyptiacus, and their response to SARS-CoV-2 infection
Functional comparisons of the virus sensor RIG-I from humans, the microbat Myotis daubentonii, and the megabat Rousettus aegyptiacus, and their response to SARS-CoV-2 infection
ABSTRACT Bats (order Chiroptera) are a major reservoir for emerging and re-emerging zoonotic viruses. Their tolerance towa...
Effects on exocytosis by two HSV-1 mutants unable to block autophagy
Effects on exocytosis by two HSV-1 mutants unable to block autophagy
ABSTRACT Herpes simplex virus 1 (HSV-1) is a prominent human pathogen that manipulates host responses to support the infec...
Isolation of novel simian adenoviruses from macaques for development of a vector for human gene therapy and vaccines
Isolation of novel simian adenoviruses from macaques for development of a vector for human gene therapy and vaccines
ABSTRACT Both human and non-human simian adenoviruses (HAdVs and SAdVs, respectively) have been used as gene therapy and v...
Direct interaction with the BRD4 carboxyl-terminal motif (CTM) and TopBP1 is required for human papillomavirus 16 E2 association with mitotic chromatin and plasmid segregation function
Direct interaction with the BRD4 carboxyl-terminal motif (CTM) and TopBP1 is required for human papillomavirus 16 E2 association with mitotic chromatin and plasmid segregation function
ABSTRACT During the human papillomavirus 16 (HPV16) life cycle, the E2 protein binds simultaneously to the viral genome an...
The matrix protein of respiratory syncytial virus suppresses interferon signaling via RACK1 association
The matrix protein of respiratory syncytial virus suppresses interferon signaling via RACK1 association
ABSTRACT Respiratory syncytial virus (RSV) is a frequent cause of respiratory illness among pediatric and elderly populati...
HSV-1 miRNAs are post-transcriptionally edited in latently infected human ganglia
HSV-1 miRNAs are post-transcriptionally edited in latently infected human ganglia
ABSTRACT Viruses use miRNAs to enable efficient replication, control host defense mechanisms, and regulate latent infectio...
Shear-reversible clusters of HIV-1 in solution: stabilized by antibodies, dispersed by mucin
Shear-reversible clusters of HIV-1 in solution: stabilized by antibodies, dispersed by mucin
ABSTRACT HIV-1 has eluded vaccine therapy for the past 40 years. The virus mutates rapidly and is protected by a shifting ...
Independent loss events of a functional tetherin gene in galliform birds
Independent loss events of a functional tetherin gene in galliform birds
ABSTRACT The restriction factor tetherin (bone marrow stromal cell antigen 2) is an interferon-inducible protein preventin...
Epstein-Barr virus LMP1 enhances levels of large extracellular vesicle-associated PD-L1
Epstein-Barr virus LMP1 enhances levels of large extracellular vesicle-associated PD-L1
ABSTRACT The circulating nature of extracellular vesicles (EVs) allows for the transfer of cargo to proximal or distant ce...
Structural and antigenic characterization of the avian adeno-associated virus capsid
Structural and antigenic characterization of the avian adeno-associated virus capsid
ABSTRACT All adeno-associated virus (AAV) vectors currently used in clinical trials or approved gene therapy biologics are...
Broad-spectrum vaccine via combined immunization routes triggers potent immunity to SARS-CoV-2 and its variants
Broad-spectrum vaccine via combined immunization routes triggers potent immunity to SARS-CoV-2 and its variants
ABSTRACT Developing broad-spectrum vaccines and optimal vaccination strategies is crucial to controlling the COVID-19 pand...
On a path toward a broad-spectrum anti-viral: inhibition of HIV-1 and coronavirus replication by SR kinase inhibitor harmine
On a path toward a broad-spectrum anti-viral: inhibition of HIV-1 and coronavirus replication by SR kinase inhibitor harmine
ABSTRACT RNA processing plays a key role in gene expression, allowing for increased protein diversity and functional compl...
Alterations in gp120 glycans or the gp41 fusion peptide-proximal region modulate the stability of the human immunodeficiency virus (HIV-1) envelope glycoprotein pretriggered conformation
Alterations in gp120 glycans or the gp41 fusion peptide-proximal region modulate the stability of the human immunodeficiency virus (HIV-1) envelope glycoprotein pretriggered conformation
ABSTRACT The human immunodeficiency virus (HIV-1) envelope glycoprotein (Env) trimer mediates entry into host cells by bin...
Limiting viral replication in hepatocytes alters Rift Valley fever virus disease manifestations
Limiting viral replication in hepatocytes alters Rift Valley fever virus disease manifestations
ABSTRACT Rift Valley fever virus (RVFV) causes mild to severe disease in humans and livestock. Outbreaks of RVFV have been...
Packaging defects in pestiviral NS4A can be compensated by mutations in NS2 and NS3
Packaging defects in pestiviral NS4A can be compensated by mutations in NS2 and NS3
ABSTRACT The non-structural (NS) proteins of the Flaviviridae members play a dual role in genome replication and virion mo...
PARP12 is required to repress the replication of a Mac1 mutant coronavirus in a cell- and tissue-specific manner
PARP12 is required to repress the replication of a Mac1 mutant coronavirus in a cell- and tissue-specific manner
ABSTRACT ADP-ribosyltransferases (ARTs) mediate the transfer of ADP-ribose from NAD+ to protein or nucleic acid substrates...
The human cellular protein NoL12 is a specific partner of the HIV-1 nucleocapsid protein NCp7
The human cellular protein NoL12 is a specific partner of the HIV-1 nucleocapsid protein NCp7
ABSTRACT The human immunodeficiency virus-1 (HIV-1) nucleocapsid protein (NCp7) is a nucleic acid chaperone protein with t...
Epstein-Barr virus-encoded miR-BART11-3p modulates the DUSP6-MAPK axis to promote gastric cancer cell proliferation and metastasis
Epstein-Barr virus-encoded miR-BART11-3p modulates the DUSP6-MAPK axis to promote gastric cancer cell proliferation and metastasis
ABSTRACT Epstein-Barr virus (EBV)-encoded miRNAs within the BamHI-A rightward transcript (BART) region are abundantly expr...
Transcription start site heterogeneity and its role in RNA fate determination distinguish HIV-1 from other retroviruses and are mediated by core promoter elements
Transcription start site heterogeneity and its role in RNA fate determination distinguish HIV-1 from other retroviruses and are mediated by core promoter elements
ABSTRACTHIV-1 uses heterogeneous transcription start sites (TSSs) to generate two RNA 5´ isoforms that adopt radically dif...
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