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The Vulnerability of the Developing Brain: Analysis of Highly Expressed Genes in Infant C57BL/6 Mouse Hippocampus in Relation to Phenotypic Annotation Derived From Mutational Studies
The Vulnerability of the Developing Brain: Analysis of Highly Expressed Genes in Infant C57BL/6 Mouse Hippocampus in Relation to Phenotypic Annotation Derived From Mutational Studies
The hippocampus has been shown to have a major role in learning and memory, but also to participate in the regulation of e...
Functional Prediction of Biological Profile During Eutrophication in Marine Environment
Functional Prediction of Biological Profile During Eutrophication in Marine Environment
In the marine environment, coastal nutrient pollution and algal blooms are increasing in many coral reefs and surface wate...
Potential Molecular Mechanisms and Remdesivir Treatment for Acute Respiratory Syndrome Corona Virus 2 Infection/COVID 19 Through RNA Sequencing and Bioinformatics Analysis
Potential Molecular Mechanisms and Remdesivir Treatment for Acute Respiratory Syndrome Corona Virus 2 Infection/COVID 19 Through RNA Sequencing and Bioinformatics Analysis
Introduction:Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) infections (COVID 19) is a progressive viral in...
Genetic Variants Assessing Crohn’s Disease Pattern in Pediatric Inflammatory Bowel Disease Patients by a Clinical Exome Survey
Genetic Variants Assessing Crohn’s Disease Pattern in Pediatric Inflammatory Bowel Disease Patients by a Clinical Exome Survey
Background:Inflammatory bowel diseases (IBDs) are complex, multifactorial disorders that comprise Crohn’s disease (CD) and...
In Silico Investigation of Conserved miRNAs and Their Targets From the Expressed Sequence Tags in Neospora Caninum Genome
In Silico Investigation of Conserved miRNAs and Their Targets From the Expressed Sequence Tags in Neospora Caninum Genome
Neospora caninum is a protozoan parasite, the etiologic agent of Neosporosis—a common cause of abortion in cattle worldwid...
Structural and Energetic Insights Into the Interaction of Niacin With the GPR109A Receptor
Structural and Energetic Insights Into the Interaction of Niacin With the GPR109A Receptor
The transmembrane G-protein coupled receptor GPR109A has been previously shown to function as a receptor for niacin in med...
FastMLST: A Multi-core Tool for Multilocus Sequence Typing of Draft Genome Assemblies
FastMLST: A Multi-core Tool for Multilocus Sequence Typing of Draft Genome Assemblies
Multilocus Sequence Typing (MLST) is a precise microbial typing approach at the intra-species level for epidemiologic and ...
Plasma Phospholipids: A Promising Simple Biochemical Parameter to Evaluate COVID-19 Infection Severity
Plasma Phospholipids: A Promising Simple Biochemical Parameter to Evaluate COVID-19 Infection Severity
Background:Coronavirus-19 (COVID-19) pandemic is a worldwide public health problem that has been known in China since Dece...
Prognostic Value Estimation of BRIP1 in Breast Cancer by Exploiting Transcriptomics Data Through Bioinformatics Approaches
Prognostic Value Estimation of BRIP1 in Breast Cancer by Exploiting Transcriptomics Data Through Bioinformatics Approaches
BRIP1 (Breast Cancer 1 Interacting Helicase 1) is a tumor suppressor gene that has vital function in preserving the geneti...
Ligand Docking Methods to Recognize Allosteric Inhibitors for G-Protein-Coupled Receptors
Ligand Docking Methods to Recognize Allosteric Inhibitors for G-Protein-Coupled Receptors
G-protein-coupled receptors (GPCRs) are membrane proteins which play an important role in many cellular processes and are ...
Prediction of the Effects of Variants and Differential Expression of Key Host Genes ACE2, TMPRSS2, and FURIN in SARS-CoV-2 Pathogenesis: An In Silico Approach
Prediction of the Effects of Variants and Differential Expression of Key Host Genes ACE2, TMPRSS2, and FURIN in SARS-CoV-2 Pathogenesis: An In Silico Approach
A new strain of the beta coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is solely responsible ...
Regression Models, Fantastic Beasts, and Where to Find Them: A Simple Tutorial for Ecologists Using R
Regression Models, Fantastic Beasts, and Where to Find Them: A Simple Tutorial for Ecologists Using R
Regression modeling is a workhorse of statistical ecology that allows to find relationships between a response variable an...
Identification of Terpenoids From Abrus precatorius Against Parkinson’s Disease Proteins Using In Silico Approach
Identification of Terpenoids From Abrus precatorius Against Parkinson’s Disease Proteins Using In Silico Approach
Parkinson’s disease (PD) is the second major neuro-degenrative disorder that causes morbidity and mortality among older po...
ProTG4: A Web Server to Approximate the Sequence of a Generic Protein From an in Silico Library of Translatable G-Quadruplex (TG4)-Mapped Peptides
ProTG4: A Web Server to Approximate the Sequence of a Generic Protein From an in Silico Library of Translatable G-Quadruplex (TG4)-Mapped Peptides
An RNA G-quadruplex in the protein coding segment of mRNA is translatable (TG4) and may potentially impact protein transla...
Molecular Modeling and Bioinformatics Analysis of Drug-Receptor Interactions in the System Formed by Glargine, Its Metabolite M1, the Insulin Receptor, and the IGF1 Receptor
Molecular Modeling and Bioinformatics Analysis of Drug-Receptor Interactions in the System Formed by Glargine, Its Metabolite M1, the Insulin Receptor, and the IGF1 Receptor
Introduction:Insulin and insulin-like growth factor type 1 (IGF1) regulate multiple physiological functions by acting on t...
A Computational Approach to Modeling an Antagonistic Angiogenic VEGFR1-IL2 Fusion Protein for Cancer Therapy
A Computational Approach to Modeling an Antagonistic Angiogenic VEGFR1-IL2 Fusion Protein for Cancer Therapy
In cancer treatment, immunotherapy has great potential for improving the prognosis of patients with hematologic and solid ...
Expression, Interaction, and Role of Pseudogene Adh6-ps1 in Cancer and other Disease Phenotypes
Expression, Interaction, and Role of Pseudogene Adh6-ps1 in Cancer and other Disease Phenotypes
Pseudogenes have been classified as functionless and their annotation is an ongoing problem. The Adh6-ps1—a mouse pseudoge...
Expression, Interaction, and Role of Pseudogene Adh6-ps1 in Cancer Phenotypes
Expression, Interaction, and Role of Pseudogene Adh6-ps1 in Cancer Phenotypes
Pseudogenes have been classified as functionless and their annotation is an ongoing problem. The Adh6-ps1—a mouse pseudoge...
Deep Learning Approach for Quantification of Fluorescently Labeled Blood Cells in Danio rerio (Zebrafish)
Deep Learning Approach for Quantification of Fluorescently Labeled Blood Cells in Danio rerio (Zebrafish)
Neutrophils are a type of white blood cell essential for the function of the innate immune system. To elucidate mechanisms...
Genome Plasticity by Insertion Sequences Learned From a Case of Radiation-Resistant Bacterium Deinococcus geothermalis
Genome Plasticity by Insertion Sequences Learned From a Case of Radiation-Resistant Bacterium Deinococcus geothermalis
The genome of the radiation-resistant bacterium Deinococcus geothermalis contains 19 types of insertion sequences (ISs), i...
Cloud Computing Enabled Big Multi-Omics Data Analytics
Cloud Computing Enabled Big Multi-Omics Data Analytics
High-throughput experiments enable researchers to explore complex multifactorial diseases through large-scale analysis of ...
DEELIG: A Deep Learning Approach to Predict Protein-Ligand Binding Affinity
DEELIG: A Deep Learning Approach to Predict Protein-Ligand Binding Affinity
Protein-ligand binding prediction has extensive biological significance. Binding affinity helps in understanding the degre...
In Silico Integrative Approach Revealed Key MicroRNAs and Associated Target Genes in Cardiorenal Syndrome
In Silico Integrative Approach Revealed Key MicroRNAs and Associated Target Genes in Cardiorenal Syndrome
Cardiorenal syndromes constellate primary dysfunction of either heart or kidney whereby one organ dysfunction leads to the...
In Silico Identification and Functional Characterization of Conserved miRNAs in the Genome of Cryptosporidium parvum
In Silico Identification and Functional Characterization of Conserved miRNAs in the Genome of Cryptosporidium parvum
Cryptosporidium parvum, a predominant causal agent of a fatal zoonotic protozoan diarrhoeal disease called cryptosporidios...
Performance of Regression Models as a Function of Experiment Noise
Performance of Regression Models as a Function of Experiment Noise
Background:A challenge in developing machine learning regression models is that it is difficult to know whether maximal pe...
In Silico Exploration of Phytoconstituents From Phyllanthus emblica and Aegle marmelos as Potential Therapeutics Against SARS-CoV-2 RdRp
In Silico Exploration of Phytoconstituents From Phyllanthus emblica and Aegle marmelos as Potential Therapeutics Against SARS-CoV-2 RdRp
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) worldwide has increased the importance of computational tools...
Reconstructing Draft Genomes Using Genome Resolved Metagenomics Reveal Arsenic Metabolizing Genes and Secondary Metabolites in Fresh Water Lake in Eastern India
Reconstructing Draft Genomes Using Genome Resolved Metagenomics Reveal Arsenic Metabolizing Genes and Secondary Metabolites in Fresh Water Lake in Eastern India
Rabindra Sarovar lake is an artificial freshwater lake in the arsenic infested eastern region of India. In this study, usi...
Structure and Function of Major SARS-CoV-2 and SARS-CoV Proteins
Structure and Function of Major SARS-CoV-2 and SARS-CoV Proteins
SARS-CoV-2 virus, the causative agent of COVID-19 pandemic, has a genomic organization consisting of 16 nonstructural prot...
A Computational-Based Drug Repurposing Method Targeting SARS-CoV-2 and its Neurological Manifestations Genes and Signaling Pathways
A Computational-Based Drug Repurposing Method Targeting SARS-CoV-2 and its Neurological Manifestations Genes and Signaling Pathways
Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as a global...
Comparison of Hyaluronic Acid Biosynthetic Genes From Different Strains of Pasteurella multocida
Comparison of Hyaluronic Acid Biosynthetic Genes From Different Strains of Pasteurella multocida
Pasteurella multocida produces a capsule composed of different polysaccharides according to the capsular serotype (A, B, D...
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