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Does melatonin administration reduce the incidence of postoperative delirium in adults? Systematic review and meta-analysis
Does melatonin administration reduce the incidence of postoperative delirium in adults? Systematic review and meta-analysis
Strengths and limitations of this studyThis review provides an up-to-date assessment of the efficacy of melatonin for prev...
Efficacy and safety of apalutamide in patients with metastatic castration-resistant prostate cancer (GENESIS): protocol for a multicentre, open-label, single-arm clinical trial
Efficacy and safety of apalutamide in patients with metastatic castration-resistant prostate cancer (GENESIS): protocol for a multicentre, open-label, single-arm clinical trial
IntroductionSince approximately 10 years ago, many new drugs with different mechanisms of action have become available for...
Effects of a computerised diagnostic decision support tool on diagnostic quality in emergency departments: study protocol of the DDx-BRO multicentre cluster randomised cross-over trial
Effects of a computerised diagnostic decision support tool on diagnostic quality in emergency departments: study protocol of the DDx-BRO multicentre cluster randomised cross-over trial
IntroductionDiagnostic error in emergency medicineGetting the right diagnosis in healthcare is key to provide an explanati...
Comparing pharmaceutical company payments in the four UK countries: a cross-sectional and social network analysis
Comparing pharmaceutical company payments in the four UK countries: a cross-sectional and social network analysis
IntroductionSome of the major pharmaceutical companies spend more on marketing than on the development of products.1–3 Ind...
Characteristics of immunisation support programmes in Canada: a scoping review and environmental scan
Characteristics of immunisation support programmes in Canada: a scoping review and environmental scan
IntroductionOne of the most valuable tools in the battle against disease transmission is immunisation.1 The resurgence of ...
Early initiation of breast feeding and associated factors among mother-baby dyads with immediate skin-to-skin contact: cross-sectional study based on the 2016 Ethiopian Demographic and Health Survey data
Early initiation of breast feeding and associated factors among mother-baby dyads with immediate skin-to-skin contact: cross-sectional study based on the 2016 Ethiopian Demographic and Health Survey data
Strengths and limitations of this studyThe study was nationally representative since the data was derived from a national ...
Vaccine coverage for recommended vaccines among splenectomised patients in Apulia, South Italy: a retrospective cohort study
Vaccine coverage for recommended vaccines among splenectomised patients in Apulia, South Italy: a retrospective cohort study
STRENGTHS AND LIMITATIONS OF THIS STUDYLarge sample size (1576 splenectomised patients).Long study period (6 years).The Ed...
Global overview of pharmacy support personnel training programmes: a scoping review protocol
Global overview of pharmacy support personnel training programmes: a scoping review protocol
IntroductionBackgroundPharmacy support personnel is the most crucial cadre that supports pharmacists in the delivery of ph...
Risk factors for cardiovascular events in patients with heterozygous familial hypercholesterolaemia: protocol for a systematic review
Risk factors for cardiovascular events in patients with heterozygous familial hypercholesterolaemia: protocol for a systematic review
IntroductionFamilial hypercholesterolaemia (FH) is a disorder of the metabolism of low-density lipoprotein (LDL) particles...
Preferences about place of end-of-life care and death of patients with life-threatening illnesses and their families: a protocol for an umbrella review
Preferences about place of end-of-life care and death of patients with life-threatening illnesses and their families: a protocol for an umbrella review
IntroductionThe diagnosis of a life-threatening disease brings important changes in the comfort and quality of life of a p...
Women and health professionals perspectives on a conditional cash transfer programme to improve pregnancy follow-up: a qualitative analysis of the NAITRE randomised controlled study
Women and health professionals perspectives on a conditional cash transfer programme to improve pregnancy follow-up: a qualitative analysis of the NAITRE randomised controlled study
Strengths and limitations of this studyThis is the first study to assess the perception of conditional cash transfer (CCT)...
Cognitive and mental fatigue in chronic pain: cognitive functions, emotional aspects, biomarkers and neuronal correlates--protocol for a descriptive cross-sectional study
Cognitive and mental fatigue in chronic pain: cognitive functions, emotional aspects, biomarkers and neuronal correlates--protocol for a descriptive cross-sectional study
IntroductionPain is one of the most frequently presenting conditions in healthcare. When pain has been present for 3 month...
Risk factors associated with cognitive impairment in patients with COVID-19: a protocol of systematic review and meta-analysis
Risk factors associated with cognitive impairment in patients with COVID-19: a protocol of systematic review and meta-analysis
STRENGTHS AND LIMITATIONS OF THIS STUDYThis meta-analysis applies multiple quality assessment tools that ensure the study ...
SPIRIT and CONSORT extensions for early phase dose-finding clinical trials: the DEFINE (DosE-FIndiNg Extensions) study protocol
SPIRIT and CONSORT extensions for early phase dose-finding clinical trials: the DEFINE (DosE-FIndiNg Extensions) study protocol
BackgroundEarly phase dose-finding (EPDF) or dose-escalation trials, also referred to as phase I or phase I/II, are critic...
Associations between older adults physical fitness level and their engagement in different types of physical activity: cross-sectional results from the OUTDOOR ACTIVE study
Associations between older adults physical fitness level and their engagement in different types of physical activity: cross-sectional results from the OUTDOOR ACTIVE study
Strengths and limitations of this studyA strength of this study is the objective assessment using validated methods of all...
Epidemiology of hospitalisations due to chickenpox and quality of life lost in community and hospital settings: protocol for a prospective cohort study across two countries
Epidemiology of hospitalisations due to chickenpox and quality of life lost in community and hospital settings: protocol for a prospective cohort study across two countries
CommunityUK: protocol V.1We will approach potential childcare environments with pre-study information to inform parents of...
Study protocol for economic evaluation of probiotic intervention for prevention of neonatal sepsis in 0-2-month old low-birth weight infants in India: the ProSPoNS trial
Study protocol for economic evaluation of probiotic intervention for prevention of neonatal sepsis in 0-2-month old low-birth weight infants in India: the ProSPoNS trial
IntroductionThere is progress towards attaining the third Sustainable Development Goal (SDG) of under-five (U5) mortality ...
ACTIVE STRIDES-CP: protocol for a randomised trial of intensive rehabilitation (combined intensive gait and cycling training) for children with moderate-to-severe bilateral cerebral palsy
ACTIVE STRIDES-CP: protocol for a randomised trial of intensive rehabilitation (combined intensive gait and cycling training) for children with moderate-to-severe bilateral cerebral palsy
Strengths and limitations of this studyThis randomised controlled trial of Active Strides-CP in children with bilateral ce...
Virtual reality-assisted cognitive behavioural therapy for outpatients with alcohol use disorder (CRAVR): a protocol for a randomised controlled trial
Virtual reality-assisted cognitive behavioural therapy for outpatients with alcohol use disorder (CRAVR): a protocol for a randomised controlled trial
IntroductionAlcohol use disorder (AUD) is a chronic brain disorder linked to more than 200 health conditions and attribute...
Nutritional and dietary diversity status of under-5 children and adolescent girls among forcibly displaced Myanmar nationals living in Bhasan Char relocation camp, Bangladesh: a cross-sectional survey
Nutritional and dietary diversity status of under-5 children and adolescent girls among forcibly displaced Myanmar nationals living in Bhasan Char relocation camp, Bangladesh: a cross-sectional survey
STRENGTHS AND LIMITATIONS OF THIS STUDYThe study used validated methods to document the dietary diversity and nutritional ...
Differences in birth weight between immigrants and natives children in Europe and Australia: a LifeCycle comparative observational cohort study
Differences in birth weight between immigrants and natives children in Europe and Australia: a LifeCycle comparative observational cohort study
STRENGTHS AND LIMITATIONS OF THIS STUDYThis study includes data from nine cohorts in six countries, allowing for a compari...
Effect of digital health, biomarker feedback and nurse or midwife-led counselling interventions to assist pregnant smokers quit: a systematic review and meta-analysis
Effect of digital health, biomarker feedback and nurse or midwife-led counselling interventions to assist pregnant smokers quit: a systematic review and meta-analysis
IntroductionTobacco smoking in pregnancy has been associated with multiple adverse health outcomes for both the mother and...
Scoping review protocol to map evidence on South-South learning exchange in family planning
Scoping review protocol to map evidence on South-South learning exchange in family planning
STRENGTHS AND LIMITATIONS OF THIS STUDYThis will be the first scoping review to identify effective approaches, barriers, f...
MEDEA randomised intervention study protocol in Cyprus, Greece and Israel for mitigation of desert dust health effects in adults with atrial fibrillation
MEDEA randomised intervention study protocol in Cyprus, Greece and Israel for mitigation of desert dust health effects in adults with atrial fibrillation
STRENGTHS AND LIMITATIONS OF THIS STUDYThroughout the study, personal monitoring through wearable sensors assesses the com...
Evaluation of the impact of a smartphone application on adherence to home exercise program for people with chronic low back pain: research protocol for a pilot randomised controlled trial
Evaluation of the impact of a smartphone application on adherence to home exercise program for people with chronic low back pain: research protocol for a pilot randomised controlled trial
IntroductionLow back pain (LBP) is a major health problem and the most common cause of disability.1 LBP is defined as a pa...
Vestibular syndromes, diagnosis and diagnostic errors in patients with dizziness presenting to the emergency department: a cross-sectional study
Vestibular syndromes, diagnosis and diagnostic errors in patients with dizziness presenting to the emergency department: a cross-sectional study
BackgroundPatients with dizziness presenting in the emergency department (ED) often suffer from accompanying symptoms such...
Prevalence of self-medication in Ghana: a systematic review and meta-analysis
Prevalence of self-medication in Ghana: a systematic review and meta-analysis
IntroductionThe practice of self-medication has received considerable attention as a major public health challenge in low-...
Modified cue exposure for adolescents with binge eating behaviour: study protocol of a randomised pilot trial called EXI(ea)T
Modified cue exposure for adolescents with binge eating behaviour: study protocol of a randomised pilot trial called EXI(ea)T
IntroductionBinge eating in adolescentsBinge eating (BE) behaviour refers to recurrent episodes of impulsive overeating ac...
Older peoples experience of the partial lockdown during the COVID-19 pandemic in Switzerland: a cross-sectional study
Older peoples experience of the partial lockdown during the COVID-19 pandemic in Switzerland: a cross-sectional study
IntroductionIn Switzerland, the Federal Council ordered a partial lockdown period lasting from 16 March to 11 May 2020 to ...
Diagnostic accuracy of heart auscultation for detecting valve disease: a systematic review
Diagnostic accuracy of heart auscultation for detecting valve disease: a systematic review
STRENGTHS AND LIMITATIONS OF THIS STUDYStrengths of this systematic review include a broad search, explicit eligibility cr...
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