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Electroacupuncture for lower urinary tract symptoms in men with benign prostatic hyperplasia: study protocol for a randomised controlled trial
Electroacupuncture for lower urinary tract symptoms in men with benign prostatic hyperplasia: study protocol for a randomised controlled trial
Primary outcomeThe two coprimary outcomes include the proportions of participants with at least 30% reduction in the IPSS ...
Switching from Dose-Intensified intravenous to SubCutaneoUS infliximab in Inflammatory Bowel Disease (DISCUS-IBD): protocol for a multicentre randomised controlled trial
Switching from Dose-Intensified intravenous to SubCutaneoUS infliximab in Inflammatory Bowel Disease (DISCUS-IBD): protocol for a multicentre randomised controlled trial
IntroductionInflammatory bowel disease (IBD) includes ulcerative colitis (UC) and Crohn’s disease (CD), two chronic, immun...
Effectiveness of an institution-based adapted physical activity programme versus a home-based self-management programme for chronic poststroke adults: protocol for a randomised controlled study
Effectiveness of an institution-based adapted physical activity programme versus a home-based self-management programme for chronic poststroke adults: protocol for a randomised controlled study
IntroductionStroke is a major public health concern, not only due to its high annual mortality rate (estimated at 5.5 mill...
Slow walking speed and health-related exit from employment among older workers over 5 years of follow-up: evidence from the Health and Employment After Fifty (HEAF) cohort study
Slow walking speed and health-related exit from employment among older workers over 5 years of follow-up: evidence from the Health and Employment After Fifty (HEAF) cohort study
Strengths and limitations of this studyData come from the Health and Employment After Fifty (HEAF) study, a large prospect...
Mentalisation-based online intervention for psychologically distressed parents: protocol of a non-randomised feasibility trial of the Lighthouse Parenting Programme-Online (LPP-Online)
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Protocol for a systematic review with prospective individual patient data meta-analysis in EGFR-mutant NSCLC with brain metastases to assess the effect of SRS+osimertinib compared to osimertinib alone: the STARLET Collaboration
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Intravenous ketamine for emergency department treatment of suicidal ideation in a paediatric population: protocol for a double-blind, randomised, placebo-controlled, parallel-arm pilot trial (KSI study)
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Guideline-based exercise management for hip and knee osteoarthritis: a cross-sectional comparison of healthcare professional and patient beliefs in Ireland
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Digital therapeutics-based lifestyle intervention for gestational diabetes mellitus prevention of high-risk pregnant women: a study protocol for a non-randomised controlled trial
Digital therapeutics-based lifestyle intervention for gestational diabetes mellitus prevention of high-risk pregnant women: a study protocol for a non-randomised controlled trial
IntroductionGestational diabetes mellitus (GDM) is defined as abnormal glucose metabolism that is first recognised during ...
Impella versus VA-ECMO for the treatment of patients with cardiogenic shock: the Impella Network Project - observational study protocol for cost-effectiveness and budget impact analyses
Impella versus VA-ECMO for the treatment of patients with cardiogenic shock: the Impella Network Project - observational study protocol for cost-effectiveness and budget impact analyses
STRENGTHS AND LIMITATIONS OF THIS STUDYThis is an observational multicentre study that will evaluate the cost-effectivenes...
Implementing Dementia Care Management into routine care: protocol for a cohort study in Siegen-Wittgenstein, Germany (RoutineDeCM)
Implementing Dementia Care Management into routine care: protocol for a cohort study in Siegen-Wittgenstein, Germany (RoutineDeCM)
IntroductionBackground and rationaleThe demographic change is an increasing challenge to industrialised and ageing societi...
Formative qualitative research on the potential for digital solutions to address diabetes care gaps in Tanzania and Sri Lanka
Formative qualitative research on the potential for digital solutions to address diabetes care gaps in Tanzania and Sri Lanka
STRENGTHS AND LIMITATIONS OF THIS STUDYThis study takes a system approach, across the continuum of care and a multidimensi...
Barriers and facilitators to perinatal care of women with disabilities in lower- and middle-income countries: a study protocol for scoping review of qualitative studies
Barriers and facilitators to perinatal care of women with disabilities in lower- and middle-income countries: a study protocol for scoping review of qualitative studies
IntroductionOver 1 billion people constituting more than 15% of the global population experience some form of disability, ...
Utility of an online well-being assessment in targeting employee well-being programmes: a cross-sectional survey study in Finland
Utility of an online well-being assessment in targeting employee well-being programmes: a cross-sectional survey study in Finland
STRENGTHS AND LIMITATIONS OF THIS STUDYThe study examines correlations between subjective evaluations of well-being and ph...
Study protocol on the efficacy of exergames-acceptance and commitment therapy program for the treatment of major depressive disorder: comparison with acceptance and commitment therapy alone and treatment-as-usual in a multicentre randomised controlled trial
Study protocol on the efficacy of exergames-acceptance and commitment therapy program for the treatment of major depressive disorder: comparison with acceptance and commitment therapy alone and treatment-as-usual in a multicentre randomised controlled trial
IntroductionMajor depressive disorder (MDD) is one of the the most common psychiatric illnesses and a leading cause of dis...
Protocol for the development of a core outcome set for clinical trials in primary sclerosing cholangitis
Protocol for the development of a core outcome set for clinical trials in primary sclerosing cholangitis
BackgroundPrimary sclerosing cholangitis (PSC) is a chronic immune-mediated liver disease characterised by multiple strict...
Norepinephrine weaning guided by the Hypotension Prediction Index in vasoplegic shock after cardiac surgery: protocol for a single-centre, open-label randomised controlled trial - the NORAHPI study
Norepinephrine weaning guided by the Hypotension Prediction Index in vasoplegic shock after cardiac surgery: protocol for a single-centre, open-label randomised controlled trial - the NORAHPI study
Study designThis is a monocentric, prospective, open-label, randomised study.Study populationThe inclusion criteria will b...
Comparing the effectiveness and cost-effectiveness of text-message reminders and telephone patient navigation to improve the uptake of faecal immunochemical test screening among non-responders in London: a randomised controlled trial protocol
Comparing the effectiveness and cost-effectiveness of text-message reminders and telephone patient navigation to improve the uptake of faecal immunochemical test screening among non-responders in London: a randomised controlled trial protocol
IntroductionColorectal cancer (CRC, also known as ‘bowel cancer’) is a leading cause of cancer-related mortality in Europe...
Improving diagnostic of cervical dysplasia among postmenopausal women aged >=50 years using local vaginal oestrogen treatment prior to colposcopy: study protocol for a multicentre randomised controlled trial (the IDEAL study)
Improving diagnostic of cervical dysplasia among postmenopausal women aged >=50 years using local vaginal oestrogen treatment prior to colposcopy: study protocol for a multicentre randomised controlled trial (the IDEAL study)
IntroductionCervical cancer incidence and mortality is relatively higher among older women compared with younger women. In...
Knowledge, attitude and practice towards insomnia and sleep hygiene among patients with chronic insomnia in Northwest China in 2023: a cross-sectional survey
Knowledge, attitude and practice towards insomnia and sleep hygiene among patients with chronic insomnia in Northwest China in 2023: a cross-sectional survey
STRENGTHS AND LIMITATIONS OF THIS STUDYA structured questionnaire was developed by the authors specifically to collect kno...
Feasibility and acceptability of general practitioners using sit-stand desks: a feasibility trial
Feasibility and acceptability of general practitioners using sit-stand desks: a feasibility trial
STRENGTHS AND LIMITATIONS OF THIS STUDYFirst study to investigate a sit–stand desk intervention among general practitioner...
PERI-operative biologic DMARD management: Stoppage or COntinuation during orthoPaEdic operations (the PERISCOPE trial) - a study protocol for a pragmatic, UK multicentre, superiority randomised controlled trial with an internal pilot, economic evaluation and nested qualitative study
PERI-operative biologic DMARD management: Stoppage or COntinuation during orthoPaEdic operations (the PERISCOPE trial) - a study protocol for a pragmatic, UK multicentre, superiority randomised controlled trial with an internal pilot, economic evaluation and nested qualitative study
Participants, interventions and outcomesThe PERISCOPE trial will be set within National Health Service (NHS) secondary car...
Phase II study in children and adults under 40 years with newly diagnosed Langerhans cell histiocytosis: protocol for an LCH-19-MSMFB clinical trial in Japan
Phase II study in children and adults under 40 years with newly diagnosed Langerhans cell histiocytosis: protocol for an LCH-19-MSMFB clinical trial in Japan
STRENGTHS AND LIMITATIONS OF THIS STUDYIn this clinical trial, we intensify treatment with the addition of intrathecal che...
PRECISE trial (Pain RElief Combination Intervention StratEgies): protocol for the clinical trial of a pregabalin-melatonin combination for fibromyalgia
PRECISE trial (Pain RElief Combination Intervention StratEgies): protocol for the clinical trial of a pregabalin-melatonin combination for fibromyalgia
IntroductionBackground and rationaleThis trial will evaluate the benefit of combining the anticonvulsant, pregabalin (PGB)...
Scoping review protocol on the perception and attitude of women on methods for collecting cervicovaginal samples for human papillomavirus testing in sub-Saharan Africa
Scoping review protocol on the perception and attitude of women on methods for collecting cervicovaginal samples for human papillomavirus testing in sub-Saharan Africa
STRENGTHS AND LIMITATIONS OF THIS STUDYThe review will involve a rigorous search and screening process aimed at maximising...
When medical assistance in dying is not a last resort option: survey of the Canadian public
When medical assistance in dying is not a last resort option: survey of the Canadian public
IntroductionGiven that medical assistance in dying (MAID) is a controversial issue involving conflicting values, public at...
Defining the Black population in Canadian health research: a scoping review protocol
Defining the Black population in Canadian health research: a scoping review protocol
IntroductionDiversity is a hallmark of Canada’s identity, culture and social fabric. The country is established on the anc...
Antibiotic dispensing practices among informal healthcare providers in low-income and middle-income countries: a scoping review protocol
Antibiotic dispensing practices among informal healthcare providers in low-income and middle-income countries: a scoping review protocol
IntroductionAntibiotics, that is, antimicrobials targeting bacteria, represent one of the most significant medical breakth...
Adolescent health and well-being check-up programme in three African cities (Y-Check): protocol for a multimethod, prospective, hybrid implementation-effectiveness study
Adolescent health and well-being check-up programme in three African cities (Y-Check): protocol for a multimethod, prospective, hybrid implementation-effectiveness study
BackgroundTo unlock human potential and accelerate progress towards achieving the Sustainable Development Goals, it is ess...
Reducing intersectional stigma among transgender women in Brazil to promote uptake of HIV testing and PrEP: study protocol for a randomised controlled trial of Manas por Manas
Reducing intersectional stigma among transgender women in Brazil to promote uptake of HIV testing and PrEP: study protocol for a randomised controlled trial of Manas por Manas
Background and rationaleTransgender (‘trans’) women in Brazil experience multiple stigmas that complicate their access to ...
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