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New latency-promoting agents for a block-and-lock functional cure strategy
New latency-promoting agents for a block-and-lock functional cure strategy
Purpose of review Currently, HIV-infected patients are treated with antiretroviral therapy. Howev
“Block and lock” viral integration sites in persons with drug-free control of HIV-1 infection
“Block and lock” viral integration sites in persons with drug-free control of HIV-1 infection
Purpose of review Elite controllers (ECs) and Posttreatment controllers (PTCs) represent a small
Harnessing natural killer cells to target HIV-1 persistence
Harnessing natural killer cells to target HIV-1 persistence
Purpose of review The purpose of this article is to review recent advances in the role of natural
Strategies to target the central nervous system HIV reservoir
Strategies to target the central nervous system HIV reservoir
Purpose of the review The central nervous system (CNS) is an hotspot for HIV persistence and may
What's in a cure: designing a broad-spectrum HIV gene therapy
What's in a cure: designing a broad-spectrum HIV gene therapy
Purpose of review The leading gene editing strategy for a human immunodeficiency virus type 1 (HI
The multifaceted nature of HIV tissue reservoirs
The multifaceted nature of HIV tissue reservoirs
Purpose of review To underline the complexity and the heterogeneity of the HIV reservoir. Recen
The sounds of silencing: dynamic epigenetic control of HIV latency
The sounds of silencing: dynamic epigenetic control of HIV latency
Purpose of review This review highlights advances in understanding the epigenetic control mechani
Persistent HIV-1 transcription during ART: time to reassess its significance?
Persistent HIV-1 transcription during ART: time to reassess its significance?
Purpose of review Despite suppressive antiretroviral therapy (ART), HIV-1 reservoirs persist and
Humanized mice for studying HIV latency and potentially its eradication
Humanized mice for studying HIV latency and potentially its eradication
Purpose of the review The quest for an HIV cure faces a formidable challenge: the persistent pres
EDITORIAL: Putting HIV in the big sleep with the block-and-lock strategy
EDITORIAL: Putting HIV in the big sleep with the block-and-lock strategy
Molecular Virology and Gene Therapy, KU Leuven, Leuven, Flanders, Belgium Correspondence to Zeger Debyser, KU...
HIV-1 subtypes and latent reservoirs
HIV-1 subtypes and latent reservoirs
Purpose of review We explore the current status of research on HIV-1 subtype-specific variations
Targeting noncoding RNAs to reactivate or eliminate latent HIV reservoirs
Targeting noncoding RNAs to reactivate or eliminate latent HIV reservoirs
Purpose of review Expression of noncoding RNAs (ncRNAs) is more tissue and cell type-specific tha
Pharmacological approaches to promote cell death of latent HIV reservoirs
Pharmacological approaches to promote cell death of latent HIV reservoirs
Purpose of review HIV requires lifelong antiviral treatment due to the persistence of a reservoir
Harnessing immune cells to eliminate HIV reservoirs
Harnessing immune cells to eliminate HIV reservoirs
Purpose of review Despite decades of insights about how CD8+ T cells and natural killer (NK) cell
Targeting HIV persistence in the tissue
Targeting HIV persistence in the tissue
Purpose of review The complex nature and distribution of the HIV reservoir in tissue of people wi
Age at ART initiation and proviral reservoir size in perinatal HIV-1 infection: considerations for ART-free remission
Age at ART initiation and proviral reservoir size in perinatal HIV-1 infection: considerations for ART-free remission
Purpose of review Achieving ART-free remission without the need for lifelong antiretroviral treat
Towards an HIV cure: one cell at a time
Towards an HIV cure: one cell at a time
Department of Microbiology, Tropical Medicine, and Immunology, School of Medicine and Health Sciences, The George W...
Obesity among women with HIV
Obesity among women with HIV
Purpose of review With the introduction of novel and more potent antiretroviral therapies (ART),
Epidemiology of obesity among people with HIV
Epidemiology of obesity among people with HIV
Purpose of review People with HIV (PWH) on antiretroviral therapy (ART) globally are disproportio
Intersections between HIV and obesity in emerging economies
Intersections between HIV and obesity in emerging economies
Purpose of review HIV epidemics are increasing in many emerging economy countries, whilst the ver
The pathogenesis of obesity in people living with HIV
The pathogenesis of obesity in people living with HIV
Purpose of review The public health challenge of overweight and obesity increasingly affects peop
Recent data on the role of antiretroviral therapy in weight gain and obesity in persons living with HIV
Recent data on the role of antiretroviral therapy in weight gain and obesity in persons living with HIV
Purpose of review Antiretroviral therapy (ART) has long been implicated in fat alterations and we
Clinical consequences of weight gain during treatment for HIV infection
Clinical consequences of weight gain during treatment for HIV infection
Purpose of review The introduction of dolutegravir, an oral integrase inhibitor, within public he
Anticipating HIV viral escape – resistance to active and passive immunization
Anticipating HIV viral escape – resistance to active and passive immunization
Purpose Active and passive immunization strategies are challenged by the extraordinary diversity
‘Immunization during ART and ATI for HIV-1 vaccine discovery/development’
‘Immunization during ART and ATI for HIV-1 vaccine discovery/development’
Purpose of review Explore whether immunization with germline-targeting Env immunogens during ART,
Accelerating HIV vaccine development through meaningful engagement of local scientists and communities
Accelerating HIV vaccine development through meaningful engagement of local scientists and communities
Purpose of review There is a need to conduct multiple experimental medicine trials in regions wit
Guiding HIV-1 vaccine development with preclinical nonhuman primate research
Guiding HIV-1 vaccine development with preclinical nonhuman primate research
Purpose of the review Nonhuman primates (NHPs) are seen as the closest animal model to humans in
Control groups for HIV prevention efficacy trials: what does the future hold?
Control groups for HIV prevention efficacy trials: what does the future hold?
Purpose of review Ending the HIV epidemic will require the development of additional effective im
Discovery medicine – the HVTN's iterative approach to developing an HIV-1 broadly neutralizing vaccine
Discovery medicine – the HVTN's iterative approach to developing an HIV-1 broadly neutralizing vaccine
Purpose of review In the past two decades, there has been an explosion in the discovery of HIV-1
Targeting enhanced neutralizing antibody responses via increased germinal center activity: early-phase vaccine trials with novel clinical designs
Targeting enhanced neutralizing antibody responses via increased germinal center activity: early-phase vaccine trials with novel clinical designs
Purpose of review Recent advances in the understanding of the difficult immunologic requirements
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