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Publisher Correction: TIGIT and PD-L1 co-blockade promotes clonal expansion of multipotent, non-exhausted antitumor T cells by facilitating co-stimulation
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 ...
Fine-tuning tumor immunogenicity with mitochondrial complex I
Fine-tuning tumor immunogenicity with mitochondrial complex I
Targeting mitochondrial metabolic activity is an active area of cancer research. A study now finds that a selective defici...
Selective deficiency of mitochondrial respiratory complex I subunits Ndufs4/6 causes tumor immunogenicity
Selective deficiency of mitochondrial respiratory complex I subunits Ndufs4/6 causes tumor immunogenicity
Cancer cells frequently rewire their metabolism to support proliferation and evade immune surveillance, but little is know...
First-in-class ultralong-target-residence-time p38α inhibitors as a mitosis-targeted therapy for colorectal cancer
First-in-class ultralong-target-residence-time p38α inhibitors as a mitosis-targeted therapy for colorectal cancer
Colorectal cancer (CRC) constitutes the second leading cause of cancer-related death worldwide and advanced CRCs are resis...
Neoadjuvant atezolizumab in combination with dual HER2 blockade plus epirubicin in women with early HER2-positive breast cancer: the randomized phase 2 ABCSG-52/ATHENE trial
Neoadjuvant atezolizumab in combination with dual HER2 blockade plus epirubicin in women with early HER2-positive breast cancer: the randomized phase 2 ABCSG-52/ATHENE trial
The role of anthracyclines in the treatment of early breast cancer (EBC) is increasingly being challenged, especially in d...
Efficacy and tolerability of neoadjuvant therapy with Talimogene laherparepvec in cutaneous basal cell carcinoma: a phase II trial (NeoBCC trial)
Efficacy and tolerability of neoadjuvant therapy with Talimogene laherparepvec in cutaneous basal cell carcinoma: a phase II trial (NeoBCC trial)
We present a single-arm, phase II, neoadjuvant trial with the oncolytic virus talimogene laherparepvec (T-VEC) in 18 patie...
ETV7 limits the antiviral and antitumor efficacy of CD8+ T cells by diverting their fate toward exhaustion
ETV7 limits the antiviral and antitumor efficacy of CD8+ T cells by diverting their fate toward exhaustion
Terminal exhaustion is a critical barrier to antitumor immunity. By integrating and analyzing single-cell RNA-sequencing a...
ERα dysfunction caused by ESR1 mutations and therapeutic pressure promotes lineage plasticity in ER+ breast cancer
ERα dysfunction caused by ESR1 mutations and therapeutic pressure promotes lineage plasticity in ER+ breast cancer
Multiple next-generation molecules targeting estrogen receptor α (ERα) are being investigated in breast cancer c...
Effects of CDKN2A loss on evolution of esophageal adenocarcinoma depend on context and time
Effects of CDKN2A loss on evolution of esophageal adenocarcinoma depend on context and time
Loss of CDKN2A is known to drive the progression of several cancers, including esophageal adenocarcinoma (EAC). Genetic an...
Metastatic patterns stratify patients with pancreatic cancer
Metastatic patterns stratify patients with pancreatic cancer
Patients with lung-metastatic pancreatic ductal adenocarcinoma survive longer than those with liver metastases. A study no...
Immunogenomic determinants of exceptional response to immune checkpoint inhibition in renal cell carcinoma
Immunogenomic determinants of exceptional response to immune checkpoint inhibition in renal cell carcinoma
Immune checkpoint inhibitors can lead to ‘exceptional’, durable responses in a subset of persons. However, the...
Prospective validation of ORACLE, a clonal expression biomarker associated with survival of patients with lung adenocarcinoma
Prospective validation of ORACLE, a clonal expression biomarker associated with survival of patients with lung adenocarcinoma
Human tumors are diverse in their natural history and response to treatment, which in part results from genetic and transc...
Ongoing replication stress tolerance and clonal T cell responses distinguish liver and lung recurrence and outcomes in pancreatic cancer
Ongoing replication stress tolerance and clonal T cell responses distinguish liver and lung recurrence and outcomes in pancreatic cancer
Patients with metastatic pancreatic ductal adenocarcinoma survive longer if disease spreads to the lung but not the liver....
Challenges and opportunities in training cancer researchers
Training the next generation of cancer researchers is essential for the cancer research enterprise. However, training prog...
The global impact of the COVID-19 pandemic on delays and disruptions in cancer care services: a systematic review and meta-analysis
The global impact of the COVID-19 pandemic on delays and disruptions in cancer care services: a systematic review and meta-analysis
The coronavirus disease 2019 pandemic substantially impacted the delivery of cancer services and programs. Here we reviewe...
Circulating tumor cell plasticity determines breast cancer therapy resistance via neuregulin 1–HER3 signaling
Circulating tumor cell plasticity determines breast cancer therapy resistance via neuregulin 1–HER3 signaling
Circulating tumor cells (CTCs) drive metastasis, the leading cause of death in individuals with breast cancer. Due to thei...
Context-dependent effects of CDKN2A and other 9p21 gene losses during the evolution of esophageal cancer
Context-dependent effects of CDKN2A and other 9p21 gene losses during the evolution of esophageal cancer
CDKN2A is a tumor suppressor located in chromosome 9p21 and frequently lost in Barrett’s esophagus (BE) and esophage...
Immunosuppressive dura-derived macrophages in leptomeningeal metastasis
Immunosuppressive dura-derived macrophages in leptomeningeal metastasis
Leptomeningeal metastases of solid tumors are associated with poor prognosis, limited treatment options and unclear immuno...
Dura immunity configures leptomeningeal metastasis immunosuppression for cerebrospinal fluid barrier invasion
Dura immunity configures leptomeningeal metastasis immunosuppression for cerebrospinal fluid barrier invasion
The cerebrospinal fluid (CSF) border accommodates diverse immune cells that permit peripheral cell immunosurveillance. How...
A cholesterol metabolite against ferroptosis
The non-apoptotic cell death known as ferroptosis has attracted much attention in cancer research during the last decade. ...
Mini colons to study cancer ex vivo
In preclinical cancer research, scientists strive to make discoveries that can be as relevant as possible to the human con...
Foundation models in clinical oncology
Digital pathology has emerged as a valuable tool in clinical oncology. However, the development of computational pathology...
Modeling and fighting immunotherapy-induced toxicity
Although immunotherapies have provided beneficial results for patients in the treatment of various hematological and solid...
Molecular glue-based RAS–MAPK targeting
Dysregulation of RAS–MAPK signaling is a driver of many solid cancers. Hence, targeting major factors of this pathway is a...
Overcoming immunoevasion in MHC class I-deficient cancers
Loss of major histocompatibility complex class I (MHC-I) is frequently observed in cancer and is associated with the escap...
Neoadjuvant immunotherapy marks a new era in oncology
Immune checkpoint blockade (ICB) has revolutionized treatment for many cancer types, including advanced metastatic cancer....
Personalized neoantigen therapy for melanoma immunotherapy
Immune checkpoint inhibitors (ICIs) have revolutionized the management of patients with high-risk early-stage and advanced...
How the bone microenvironment shapes the pre-metastatic niche and metastasis
How the bone microenvironment shapes the pre-metastatic niche and metastasis
The bone is a frequent metastatic site, with changes in the mineralized bone and the bone marrow milieu that can also prim...
Mapping the functional network of human cancer through machine learning and pan-cancer proteogenomics
Mapping the functional network of human cancer through machine learning and pan-cancer proteogenomics
Large-scale omics profiling has uncovered a vast array of somatic mutations and cancer-associated proteins, posing substan...
Anti-metastatic extracellular vesicles carrying DNA
Anti-metastatic extracellular vesicles carrying DNA
Cancer cells often secrete extracellular vesicles (EVs), bubble-like structures thought to elicit pro-metastatic states. N...
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