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KRAS degradation averts PDAC chemoresistance
KRAS degradation averts PDAC chemoresistance
Effectively targeting deregulated KRAS signaling remains an unmet clinical need, as current approaches commonly lead to th...
γδ T cells as unconventional targets of checkpoint blockade
γδ T cells as unconventional targets of checkpoint blockade
Identifying which patients will benefit most from immune checkpoint blockade (ICB) is an important clinical challenge. A s...
Trans-Atlantic twists and turns
Trans-Atlantic twists and turns
Johanna Joyce received her PhD from the University of Cambridge, and did postdoctoral research at the University of Califo...
Tissue-specific thresholds of mutation burden associated with anti-PD-1/L1 therapy benefit and prognosis in microsatellite-stable cancers
Tissue-specific thresholds of mutation burden associated with anti-PD-1/L1 therapy benefit and prognosis in microsatellite-stable cancers
Immune checkpoint inhibitors (ICIs) targeting programmed cell death protein 1 or its ligand (PD-1/L1) have expanded the tr...
The pleiotropic functions of reactive oxygen species in cancer
The pleiotropic functions of reactive oxygen species in cancer
Cellular redox homeostasis is an essential, dynamic process that ensures the balance between reducing and oxidizing reacti...
Threonine fuels glioblastoma through YRDC-mediated codon-biased translational reprogramming
Threonine fuels glioblastoma through YRDC-mediated codon-biased translational reprogramming
Cancers commonly reprogram translation and metabolism, but little is known about how these two features coordinate in canc...
Synthetic dual co-stimulation increases the potency of HIT and TCR-targeted cell therapies
Synthetic dual co-stimulation increases the potency of HIT and TCR-targeted cell therapies
Chimeric antigen receptor T cells have dramatically improved the treatment of hematologic malignancies. T cell antigen rec...
Author Correction: Efferocytosis reprograms the tumor microenvironment to promote pancreatic cancer liver metastasis
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Cytidine deaminases APOBEC3C and APOBEC3D promote DNA replication stress resistance in pancreatic cancer cells
Cytidine deaminases APOBEC3C and APOBEC3D promote DNA replication stress resistance in pancreatic cancer cells
Gemcitabine is a potent inhibitor of DNA replication and is a mainstay therapeutic for diverse cancers, particularly pancr...
A deep learning model of tumor cell architecture elucidates response and resistance to CDK4/6 inhibitors
A deep learning model of tumor cell architecture elucidates response and resistance to CDK4/6 inhibitors
Cyclin-dependent kinase 4 and 6 inhibitors (CDK4/6is) have revolutionized breast cancer therapy. However, <50% of p...
Improving long-term outcomes in pediatric low-grade glioma
Improving long-term outcomes in pediatric low-grade glioma
Low-grade glioma is a tumor type that affects the central nervous system, with favorable survival outcomes in children and...
Sarcoma microenvironment cell states and ecosystems are associated with prognosis and predict response to immunotherapy
Sarcoma microenvironment cell states and ecosystems are associated with prognosis and predict response to immunotherapy
Characterization of the diverse malignant and stromal cell states that make up soft tissue sarcomas and their correlation ...
Modeling T cell temporal response to cancer immunotherapy rationalizes development of combinatorial treatment protocols
Modeling T cell temporal response to cancer immunotherapy rationalizes development of combinatorial treatment protocols
Successful immunotherapy relies on triggering complex responses involving T cell dynamics in tumors and the periphery. Cha...
Redistribution of mutation risk in cancer
Redistribution of mutation risk in cancer
A genome-wide study of variation in mutation rates in human cancer reveals robust patterns of change in mutation risk acro...
ATX restricts anti-tumor eosinophil responses
ATX restricts anti-tumor eosinophil responses
Autotaxin (ATX) produces lysophosphatidic acid (LPA), which directly promotes pancreatic ductal adenocarcinoma (PDAC) grow...
Targeting PRMT9-mediated arginine methylation suppresses cancer stem cell maintenance and elicits cGAS-mediated anticancer immunity
Targeting PRMT9-mediated arginine methylation suppresses cancer stem cell maintenance and elicits cGAS-mediated anticancer immunity
Current anticancer therapies cannot eliminate all cancer cells, which hijack normal arginine methylation as a means to pro...
Clearance of dead cells by efferocytosis promotes liver metastasis in pancreatic cancer
Clearance of dead cells by efferocytosis promotes liver metastasis in pancreatic cancer
Pancreatic cancer liver metastases show high levels of immunosuppressive macrophages, which promote tumor growth. We found...
Targeting LGR4–Wnt activates ferroptosis and reverses drug resistance in colorectal cancer
Targeting LGR4–Wnt activates ferroptosis and reverses drug resistance in colorectal cancer
Our study reveals that the LGR4–Wnt signaling pathway dictates both ferroptosis and stemness traits to confer drug r...
Entinostat, nivolumab and ipilimumab for women with advanced HER2-negative breast cancer: a phase Ib trial
Entinostat, nivolumab and ipilimumab for women with advanced HER2-negative breast cancer: a phase Ib trial
We report the results of 24 women, 50% (N = 12) with hormone receptor-positive breast cancer and 50% (N ...
Efferocytosis reprograms the tumor microenvironment to promote pancreatic cancer liver metastasis
Efferocytosis reprograms the tumor microenvironment to promote pancreatic cancer liver metastasis
Pancreatic ductal adenocarcinoma is a highly metastatic disease and macrophages support liver metastases. Efferocytosis, o...
Clinical and translational attributes of immune-related adverse events
Clinical and translational attributes of immune-related adverse events
With immune checkpoint inhibitors (ICIs) becoming the mainstay of treatment for many cancers, managing their immune-relate...
Melanoma leverages local cues to promote liver-specific metastasis
Melanoma leverages local cues to promote liver-specific metastasis
Using CRISPR–Cas9 screens, we found that cancer-cell-intrinsic loss of Pip4k2c conferred liver-metastatic organotrop...
Integrated multiomic profiling of breast cancer in the Chinese population reveals patient stratification and therapeutic vulnerabilities
Integrated multiomic profiling of breast cancer in the Chinese population reveals patient stratification and therapeutic vulnerabilities
Molecular profiling guides precision treatment of breast cancer; however, Asian patients are underrepresented in publicly ...
Repurposing the dopamine transporter antagonist vanoxerine to treat colorectal cancer
Repurposing the dopamine transporter antagonist vanoxerine to treat colorectal cancer
Self-renewing cancer stem cells drive tumor initiation and progression and represent a major target for therapeutic develo...
The dopamine transporter antagonist vanoxerine inhibits G9a and suppresses cancer stem cell functions in colon tumors
The dopamine transporter antagonist vanoxerine inhibits G9a and suppresses cancer stem cell functions in colon tumors
Cancer stem cells (CSCs), functionally characterized by self-renewal and tumor-initiating activity, contribute to decrease...
Mitochondrial DNA mutation enhances sensitivity to immunotherapy in melanoma
Mitochondrial DNA mutation enhances sensitivity to immunotherapy in melanoma
Mitochondrial DNA mutations are present in over 50% of all cancers, and truncating mutations in several genes encoding com...
PD-L2 expression in senescent cancer cells limits tumor clearance after chemotherapy
PD-L2 expression in senescent cancer cells limits tumor clearance after chemotherapy
Senescent cancer cells, which are characteristically present in tumors after genotoxic therapies, upregulate the immune ch...
Roadmap for a European cancer data management and precision medicine infrastructure
Roadmap for a European cancer data management and precision medicine infrastructure
Gold-standard cancer data management is pivotal to enable precision medicine for European citizens. Achieving this goal re...