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Evolving cell states and oncogenic drivers during the progression of IDH-mutant gliomas
Evolving cell states and oncogenic drivers during the progression of IDH-mutant gliomas
Isocitrate dehydrogenase (IDH) mutants define a class of gliomas that are initially slow-growing but inevitably progress t...
Transcription and DNA replication collisions lead to large tandem duplications and expose targetable therapeutic vulnerabilities in cancer
Transcription and DNA replication collisions lead to large tandem duplications and expose targetable therapeutic vulnerabilities in cancer
Despite the abundance of somatic structural variations (SVs) in cancer, the underlying molecular mechanisms of their forma...
Single-cell transcriptomic landscape deciphers olfactory neuroblastoma subtypes and intra-tumoral heterogeneity
Single-cell transcriptomic landscape deciphers olfactory neuroblastoma subtypes and intra-tumoral heterogeneity
Olfactory neuroblastoma (ONB) is a rare malignancy known to originate from the olfactory epithelium. The complex tumor eco...
The pro-oncogenic noncanonical activity of a RAS•GTP:RanGAP1 complex facilitates nuclear protein export
The pro-oncogenic noncanonical activity of a RAS•GTP:RanGAP1 complex facilitates nuclear protein export
Canonical RAS signaling, including PI3K/AKT- and RAF/MEK-dependent activities, results mainly from RAS•GTP interacti...
Modeling adenoma–carcinoma progression from a single MLH1-knockout cell via colon organoids
Modeling adenoma–carcinoma progression from a single MLH1-knockout cell via colon organoids
Starting from a single MLH1-knockout human colon cell, we modeled the transition of daughter cells and resultant organoids...
Recapitulating the adenoma–carcinoma sequence by selection of four spontaneous oncogenic mutations in mismatch-repair-deficient human colon organoids
Recapitulating the adenoma–carcinoma sequence by selection of four spontaneous oncogenic mutations in mismatch-repair-deficient human colon organoids
Carcinogenesis results from the sequential acquisition of oncogenic mutations that convert normal cells into invasive, met...
Defining the transcriptional lineages of breast cancer subtypes
Defining the transcriptional lineages of breast cancer subtypes
In this work, we demonstrate the transcriptional networks that link breast cancer subtypes and their cells of origin, and ...
A 3D genome view of colon cancer initiation
A 3D genome view of colon cancer initiation
The early molecular events driving cancer initiation remain elusive, hampering prognostic accuracy. A comparative analysis...
Global loss of promoter–enhancer connectivity and rebalancing of gene expression during early colorectal cancer carcinogenesis
Global loss of promoter–enhancer connectivity and rebalancing of gene expression during early colorectal cancer carcinogenesis
Although three-dimensional (3D) genome architecture is crucial for gene regulation, its role in disease remains elusive. W...
Multiomic analysis of familial adenomatous polyposis reveals molecular pathways associated with early tumorigenesis
Multiomic analysis of familial adenomatous polyposis reveals molecular pathways associated with early tumorigenesis
Familial adenomatous polyposis (FAP) is a genetic disease causing hundreds of premalignant polyps in affected persons and ...
Differential chromatin accessibility and transcriptional dynamics define breast cancer subtypes and their lineages
Differential chromatin accessibility and transcriptional dynamics define breast cancer subtypes and their lineages
Breast cancer (BC) is defined by distinct molecular subtypes with different cells of origin. The transcriptional networks ...
Selenocysteine tRNA methylation promotes oxidative stress resistance in melanoma metastasis
Selenocysteine tRNA methylation promotes oxidative stress resistance in melanoma metastasis
Selenocysteine-containing proteins play a central role in redox homeostasis. Their translation is a highly regulated proce...
Phase separation rewires chromatin in breast cancer
Phase separation rewires chromatin in breast cancer
Liquid–liquid phase separation has been shown to be involved in tumorigenesis. Phosphorylated HDAC6 is now found to ...
Developmental mosaicism underlying EGFR-mutant lung cancer presenting with multiple primary tumors
Developmental mosaicism underlying EGFR-mutant lung cancer presenting with multiple primary tumors
Although the development of multiple primary tumors in smokers with lung cancer can be attributed to carcinogen-induced fi...
Two distinct epithelial-to-mesenchymal transition programs control invasion and inflammation in segregated tumor cell populations
Two distinct epithelial-to-mesenchymal transition programs control invasion and inflammation in segregated tumor cell populations
Epithelial-to-mesenchymal transition (EMT) triggers cell plasticity in embryonic development, adult injured tissues and ca...
The neuroendocrine transition in prostate cancer is dynamic and dependent on ASCL1
The neuroendocrine transition in prostate cancer is dynamic and dependent on ASCL1
Lineage plasticity is a hallmark of cancer progression that impacts therapy outcomes, yet the mechanisms mediating this pr...
Spatial single-cell protein landscape reveals vimentinhigh macrophages as immune-suppressive in the microenvironment of hepatocellular carcinoma
Spatial single-cell protein landscape reveals vimentinhigh macrophages as immune-suppressive in the microenvironment of hepatocellular carcinoma
Tumor microenvironment heterogeneity in hepatocellular carcinoma (HCC) on a spatial single-cell resolution is unclear. Her...
Co-targeting metabolism and epigenetics in MDS with telaglenastat and azacytidine
Co-targeting metabolism and epigenetics in MDS with telaglenastat and azacytidine
Azacytidine is used as standard treatment for myelodysplastic syndrome (MDS) but, although it induces responses, remission...
Publisher Correction: Integrative proteogenomic profiling of high-risk prostate cancer samples from Chinese patients indicates metabolic vulnerabilities and diagnostic biomarkers
These authors contributed equally: Baijun Dong, Jun-Yu Xu, Yuqi Huang, Jiacheng Guo, Qun Dong, Yanqing Wang.These authors ...
CAR-redirected natural killer T cells demonstrate superior antitumor activity to CAR-T cells through multimodal CD1d-dependent mechanisms
CAR-redirected natural killer T cells demonstrate superior antitumor activity to CAR-T cells through multimodal CD1d-dependent mechanisms
Human natural killer T (NKT) cells have been proposed as a promising cell platform for chimeric antigen receptor (CAR) the...
Leveraging the potential for deintensification in cancer care
Evidence-based reductions in cancer treatment that still preserve outcomes can result in an improved quality of life for p...
Spatial analysis reveals targetable macrophage-mediated mechanisms of immune evasion in hepatocellular carcinoma minimal residual disease
Spatial analysis reveals targetable macrophage-mediated mechanisms of immune evasion in hepatocellular carcinoma minimal residual disease
Hepatocellular carcinoma (HCC) frequently recurs from minimal residual disease (MRD), which persists after therapy. Here, ...
Deciphering the response to BCMA CAR T cell therapy
Deciphering the response to BCMA CAR T cell therapy
Despite the promise of chimeric antigen receptor (CAR) T cell therapy, predicting patient response is challenging. Single-...
Glutaminase inhibition in combination with azacytidine in myelodysplastic syndromes: a phase 1b/2 clinical trial and correlative analyses
Glutaminase inhibition in combination with azacytidine in myelodysplastic syndromes: a phase 1b/2 clinical trial and correlative analyses
Malignancies are reliant on glutamine as an energy source and a facilitator of aberrant DNA methylation. We demonstrate pr...
Targeting therapy-persistent residual disease
Targeting therapy-persistent residual disease
Disease relapse driven by acquired drug resistance limits the effectiveness of most systemic anti-cancer agents. Targeting...
Vascular heterogeneity of tight junction Claudins guides organotropic metastasis
Vascular heterogeneity of tight junction Claudins guides organotropic metastasis
Carcinomas are associated with metastasis to specific organs while sparing others. Breast cancer presents with lung metast...
Neoadjuvant gemcitabine–cisplatin plus tislelizumab in persons with resectable muscle-invasive bladder cancer: a multicenter, single-arm, phase 2 trial
Neoadjuvant gemcitabine–cisplatin plus tislelizumab in persons with resectable muscle-invasive bladder cancer: a multicenter, single-arm, phase 2 trial
Programmed death 1 blockade (tislelizumab) has been approved for metastatic urothelial carcinoma but not as part of neoadj...
Antibody avidity meets multiple myeloma
Antibody avidity meets multiple myeloma
In the ongoing search for innovative treatments to combat refractory and relapsed cancer, new preclinical work in multiple...
MCL1 inhibitor BRD-810 kills cancer cells while minimizing risk of cardiotoxicity
MCL1 inhibitor BRD-810 kills cancer cells while minimizing risk of cardiotoxicity
The anti-apoptotic protein MCL1 is a therapeutic target in cancer, but long-term MCL1 inhibition has been found to increas...
ISB 2001 trispecific T cell engager shows strong tumor cytotoxicity and overcomes immune escape mechanisms of multiple myeloma cells
ISB 2001 trispecific T cell engager shows strong tumor cytotoxicity and overcomes immune escape mechanisms of multiple myeloma cells
Despite recent advances in immunotherapies targeting single tumor-associated antigens, patients with multiple myeloma even...
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