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Immunosuppressive dura-derived macrophages in leptomeningeal metastasis
Immunosuppressive dura-derived macrophages in leptomeningeal metastasis
Leptomeningeal metastases of solid tumors are associated with poor prognosis, limited treatment options and unclear immuno...
Dura immunity configures leptomeningeal metastasis immunosuppression for cerebrospinal fluid barrier invasion
Dura immunity configures leptomeningeal metastasis immunosuppression for cerebrospinal fluid barrier invasion
The cerebrospinal fluid (CSF) border accommodates diverse immune cells that permit peripheral cell immunosurveillance. How...
A cholesterol metabolite against ferroptosis
The non-apoptotic cell death known as ferroptosis has attracted much attention in cancer research during the last decade. ...
Mini colons to study cancer ex vivo
In preclinical cancer research, scientists strive to make discoveries that can be as relevant as possible to the human con...
Foundation models in clinical oncology
Digital pathology has emerged as a valuable tool in clinical oncology. However, the development of computational pathology...
Modeling and fighting immunotherapy-induced toxicity
Although immunotherapies have provided beneficial results for patients in the treatment of various hematological and solid...
Molecular glue-based RAS–MAPK targeting
Dysregulation of RAS–MAPK signaling is a driver of many solid cancers. Hence, targeting major factors of this pathway is a...
Overcoming immunoevasion in MHC class I-deficient cancers
Loss of major histocompatibility complex class I (MHC-I) is frequently observed in cancer and is associated with the escap...
Neoadjuvant immunotherapy marks a new era in oncology
Immune checkpoint blockade (ICB) has revolutionized treatment for many cancer types, including advanced metastatic cancer....
Personalized neoantigen therapy for melanoma immunotherapy
Immune checkpoint inhibitors (ICIs) have revolutionized the management of patients with high-risk early-stage and advanced...
How the bone microenvironment shapes the pre-metastatic niche and metastasis
How the bone microenvironment shapes the pre-metastatic niche and metastasis
The bone is a frequent metastatic site, with changes in the mineralized bone and the bone marrow milieu that can also prim...
Mapping the functional network of human cancer through machine learning and pan-cancer proteogenomics
Mapping the functional network of human cancer through machine learning and pan-cancer proteogenomics
Large-scale omics profiling has uncovered a vast array of somatic mutations and cancer-associated proteins, posing substan...
Anti-metastatic extracellular vesicles carrying DNA
Anti-metastatic extracellular vesicles carrying DNA
Cancer cells often secrete extracellular vesicles (EVs), bubble-like structures thought to elicit pro-metastatic states. N...
Unique structural configuration of EV-DNA primes Kupffer cell-mediated antitumor immunity to prevent metastatic progression
Unique structural configuration of EV-DNA primes Kupffer cell-mediated antitumor immunity to prevent metastatic progression
Extracellular vesicles (EVs) transport biomolecules that mediate intercellular communication. We previously showed that EV...
Bone marrow progenitor-like cells against leukemia cure
Bone marrow progenitor-like cells against leukemia cure
Relapse in T cell acute lymphoblastic leukemia (T-ALL) constitutes a challenge. A subclonal population of bone marrow prog...
A multiomic atlas identifies a treatment-resistant, bone marrow progenitor-like cell population in T cell acute lymphoblastic leukemia
A multiomic atlas identifies a treatment-resistant, bone marrow progenitor-like cell population in T cell acute lymphoblastic leukemia
Refractoriness to initial chemotherapy and relapse after remission are the main obstacles to curing T cell acute lymphobla...
Evolving cell states and oncogenic drivers during the progression of IDH-mutant gliomas
Evolving cell states and oncogenic drivers during the progression of IDH-mutant gliomas
Isocitrate dehydrogenase (IDH) mutants define a class of gliomas that are initially slow-growing but inevitably progress t...
Transcription and DNA replication collisions lead to large tandem duplications and expose targetable therapeutic vulnerabilities in cancer
Transcription and DNA replication collisions lead to large tandem duplications and expose targetable therapeutic vulnerabilities in cancer
Despite the abundance of somatic structural variations (SVs) in cancer, the underlying molecular mechanisms of their forma...
Single-cell transcriptomic landscape deciphers olfactory neuroblastoma subtypes and intra-tumoral heterogeneity
Single-cell transcriptomic landscape deciphers olfactory neuroblastoma subtypes and intra-tumoral heterogeneity
Olfactory neuroblastoma (ONB) is a rare malignancy known to originate from the olfactory epithelium. The complex tumor eco...
The pro-oncogenic noncanonical activity of a RAS•GTP:RanGAP1 complex facilitates nuclear protein export
The pro-oncogenic noncanonical activity of a RAS•GTP:RanGAP1 complex facilitates nuclear protein export
Canonical RAS signaling, including PI3K/AKT- and RAF/MEK-dependent activities, results mainly from RAS•GTP interacti...
Modeling adenoma–carcinoma progression from a single MLH1-knockout cell via colon organoids
Modeling adenoma–carcinoma progression from a single MLH1-knockout cell via colon organoids
Starting from a single MLH1-knockout human colon cell, we modeled the transition of daughter cells and resultant organoids...
Recapitulating the adenoma–carcinoma sequence by selection of four spontaneous oncogenic mutations in mismatch-repair-deficient human colon organoids
Recapitulating the adenoma–carcinoma sequence by selection of four spontaneous oncogenic mutations in mismatch-repair-deficient human colon organoids
Carcinogenesis results from the sequential acquisition of oncogenic mutations that convert normal cells into invasive, met...
Defining the transcriptional lineages of breast cancer subtypes
Defining the transcriptional lineages of breast cancer subtypes
In this work, we demonstrate the transcriptional networks that link breast cancer subtypes and their cells of origin, and ...
A 3D genome view of colon cancer initiation
A 3D genome view of colon cancer initiation
The early molecular events driving cancer initiation remain elusive, hampering prognostic accuracy. A comparative analysis...
Global loss of promoter–enhancer connectivity and rebalancing of gene expression during early colorectal cancer carcinogenesis
Global loss of promoter–enhancer connectivity and rebalancing of gene expression during early colorectal cancer carcinogenesis
Although three-dimensional (3D) genome architecture is crucial for gene regulation, its role in disease remains elusive. W...
Multiomic analysis of familial adenomatous polyposis reveals molecular pathways associated with early tumorigenesis
Multiomic analysis of familial adenomatous polyposis reveals molecular pathways associated with early tumorigenesis
Familial adenomatous polyposis (FAP) is a genetic disease causing hundreds of premalignant polyps in affected persons and ...
Differential chromatin accessibility and transcriptional dynamics define breast cancer subtypes and their lineages
Differential chromatin accessibility and transcriptional dynamics define breast cancer subtypes and their lineages
Breast cancer (BC) is defined by distinct molecular subtypes with different cells of origin. The transcriptional networks ...
Selenocysteine tRNA methylation promotes oxidative stress resistance in melanoma metastasis
Selenocysteine tRNA methylation promotes oxidative stress resistance in melanoma metastasis
Selenocysteine-containing proteins play a central role in redox homeostasis. Their translation is a highly regulated proce...
Phase separation rewires chromatin in breast cancer
Phase separation rewires chromatin in breast cancer
Liquid–liquid phase separation has been shown to be involved in tumorigenesis. Phosphorylated HDAC6 is now found to ...
Developmental mosaicism underlying EGFR-mutant lung cancer presenting with multiple primary tumors
Developmental mosaicism underlying EGFR-mutant lung cancer presenting with multiple primary tumors
Although the development of multiple primary tumors in smokers with lung cancer can be attributed to carcinogen-induced fi...
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