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p53 at the crossroads of tumor immunity
p53 at the crossroads of tumor immunity
The p53 tumor suppressor protein has a plethora of cell-intrinsic functions and consequences that impact diverse cell type...
Determinants of resistance and response to melanoma therapy
Determinants of resistance and response to melanoma therapy
Metastatic melanoma is among the most enigmatic advanced cancers to clinically manage despite immense progress in the way ...
A deep-learning framework to predict cancer treatment response from histopathology images through imputed transcriptomics
A deep-learning framework to predict cancer treatment response from histopathology images through imputed transcriptomics
Advances in artificial intelligence have paved the way for leveraging hematoxylin and eosin-stained tumor slides for preci...
A first-in-class selective inhibitor of EGFR and PI3K offers a single-molecule approach to targeting adaptive resistance
A first-in-class selective inhibitor of EGFR and PI3K offers a single-molecule approach to targeting adaptive resistance
Despite tremendous progress in precision oncology, adaptive resistance mechanisms limit the long-term effectiveness of mol...
Tumor evolution metrics predict recurrence beyond 10 years in locally advanced prostate cancer
Tumor evolution metrics predict recurrence beyond 10 years in locally advanced prostate cancer
Cancer evolution lays the groundwork for predictive oncology. Testing evolutionary metrics requires quantitative measureme...
Building a translational cancer dependency map for The Cancer Genome Atlas
Building a translational cancer dependency map for The Cancer Genome Atlas
Cancer dependency maps have accelerated the discovery of tumor vulnerabilities that can be exploited as drug targets when ...
Author Correction: Clinical implementation of artificial-intelligence-assisted detection of breast cancer metastases in sentinel lymph nodes: the CONFIDENT-B single-center, non-randomized clinical trial
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Targeting HIF-1 to treat AML
Targeting HIF-1 to treat AML
Acute myeloid leukemia (AML) is an aggressive hematological cancer with limited treatment options. A study now provides co...
Clinical implementation of artificial-intelligence-assisted detection of breast cancer metastases in sentinel lymph nodes: the CONFIDENT-B single-center, non-randomized clinical trial
Clinical implementation of artificial-intelligence-assisted detection of breast cancer metastases in sentinel lymph nodes: the CONFIDENT-B single-center, non-randomized clinical trial
Pathologists’ assessment of sentinel lymph nodes (SNs) for breast cancer (BC) metastases is a treatment-guiding yet ...
Pharmacological targeting of the cancer epigenome
Pharmacological targeting of the cancer epigenome
Epigenetic dysregulation is increasingly appreciated as a hallmark of cancer, including disease initiation, maintenance an...
The proteogenomic landscape of multiple myeloma reveals insights into disease biology and therapeutic opportunities
The proteogenomic landscape of multiple myeloma reveals insights into disease biology and therapeutic opportunities
Multiple myeloma (MM) is a plasma cell malignancy of the bone marrow. Despite therapeutic advances, MM remains incurable, ...
Milestones in tumor vascularization and its therapeutic targeting
Milestones in tumor vascularization and its therapeutic targeting
Research into the mechanisms and manifestations of solid tumor vascularization was launched more than 50 years ago with th...
Multidimensional analysis reveals predictive markers for CAR-T efficacy
Multidimensional analysis reveals predictive markers for CAR-T efficacy
At present, six CAR-T therapies are FDA approved to treat hematological cancers, but not all patients respond. A new study...
Author Correction: Direct and selective pharmacological disruption of the YAP–TEAD interface by IAG933 inhibits Hippo-dependent and RAS–MAPK-altered cancers
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Nucleotide metabolism in cancer cells fuels a UDP-driven macrophage cross-talk, promoting immunosuppression and immunotherapy resistance
Nucleotide metabolism in cancer cells fuels a UDP-driven macrophage cross-talk, promoting immunosuppression and immunotherapy resistance
Many individuals with cancer are resistant to immunotherapies. Here, we identify the gene encoding the pyrimidine salvage ...
Fibrotic tumors tune metabolism for immune evasion
Fibrotic tumors tune metabolism for immune evasion
Tumor fibrosis is known to suppress anti-tumor immunity. A new study now highlights the role of tumor-associated macrophag...
LORIS robustly predicts patient outcomes with immune checkpoint blockade therapy using common clinical, pathologic and genomic features
LORIS robustly predicts patient outcomes with immune checkpoint blockade therapy using common clinical, pathologic and genomic features
Despite the revolutionary impact of immune checkpoint blockade (ICB) in cancer treatment, accurately predicting patient re...
Tumor-associated macrophages restrict CD8+ T cell function through collagen deposition and metabolic reprogramming of the breast cancer microenvironment
Tumor-associated macrophages restrict CD8+ T cell function through collagen deposition and metabolic reprogramming of the breast cancer microenvironment
Tumor progression is accompanied by fibrosis, a condition of excessive extracellular matrix accumulation, which is associa...
Constructing co-stimulation to boost TCR therapy
Constructing co-stimulation to boost TCR therapy
T cell receptor (TCR)-engineered T cells offer great promise for targeting tumor antigens in cancer therapy. A synthetic f...
Selective targeting of malignant T cells
Selective targeting of malignant T cells
Targeted therapies that use small-molecule inhibitors for the treatment of T cell blood cancer exist only for certain subt...
Targeting a lineage-specific PI3Kɣ–Akt signaling module in acute myeloid leukemia using a heterobifunctional degrader molecule
Targeting a lineage-specific PI3Kɣ–Akt signaling module in acute myeloid leukemia using a heterobifunctional degrader molecule
Dose-limiting toxicity poses a major limitation to the clinical utility of targeted cancer therapies, often arising from t...
Author Correction: Identification of a clinically efficacious CAR T cell subset in diffuse large B cell lymphoma by dynamic multidimensional single-cell profiling
Department of Chemical and Biomolecular Engineering, University of Houston, Houston, TX, USAAli Rezvan, Gabrielle Romain, ...
APOBEC3 upregulation drives gemcitabine resistance
APOBEC3 upregulation drives gemcitabine resistance
Gemcitabine is a widely used chemotherapy drug that acts by targeting DNA replication. Understanding why many tumors are u...
Author Correction: Targeting LIPA independent of its lipase activity is a therapeutic strategy in solid tumors via induction of endoplasmic reticulum stress
Department of Urology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USAXihui Liu, Shourya Kumar,...
Targeting TAK1 in microglia to treat CAR T cell neurotoxicity
Targeting TAK1 in microglia to treat CAR T cell neurotoxicity
We profiled microglia using single-cell multi-omics techniques in lymphoma-bearing mice and patients who developed neuroto...
Quantum computing for oncology
Quantum computing for oncology
As quantum technology advances, it holds immense potential to accelerate oncology discovery through enhanced molecular mod...
Targeting TGFβ-activated kinase-1 activation in microglia reduces CAR T immune effector cell-associated neurotoxicity syndrome
Targeting TGFβ-activated kinase-1 activation in microglia reduces CAR T immune effector cell-associated neurotoxicity syndrome
Cancer immunotherapy with chimeric antigen receptor (CAR) T cells can cause immune effector cell-associated neurotoxicity ...
Identification of a clinically efficacious CAR T cell subset in diffuse large B cell lymphoma by dynamic multidimensional single-cell profiling
Identification of a clinically efficacious CAR T cell subset in diffuse large B cell lymphoma by dynamic multidimensional single-cell profiling
Chimeric antigen receptor (CAR) T cells used for the treatment of B cell malignancies can identify T cell subsets with sup...
Publisher Correction: Circadian regulation of cancer stem cells and the tumor microenvironment during metastasis
Authors and AffiliationsInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Sin...
Connie Eaves (1944–2024)
Connie Eaves (1944–2024)
Connie was born in Ottawa in May 1944 as one of four children to Israel and Mary Halperin. Her father...
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