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In-Silico Method for Predicting Pathogenic Missense Variants Using Online Tools: AURKA Gene A as a Model
Background: In-silico analysis provides a fast, simple, and cost-free method for identifying potentially pathogenic single...
Silver Nanoparticles as Catalysts of Foeniculum vulgare Callus Formation and Its Content of Vitamins and Some Fatty acids
Background: Plants are a precious resource of a wide range of secondary metabolites that are valuable as flavours, pharmac...
Molecular Cloning of the Extracellular Lipases of Bacillus amyloliquefaciens Isolated from Agrifood Wastes
Background: The lipase enzyme (EC: 3.1.1.3) is one of the most important catalysts in food, dairy, detergent, and textile ...
Increased Expression Level of Human Blood Clotting Factor VIII Using NS0 Cell Line as a Host Cells
Abstract Background: Coagulation factor VIII (FVIII) is applied for spontaneous hemorrhaging inhibition and excessive ble...
Investigation of Common Pathways and Putative Biomarker Candidates of Colorectal Cancer and Insomnia by Using Integrative in-silico Approaches
Background: Colorectal cancer (CRC) is one of the leading causes of cancer-related mortalities across the globe. Accumulat...
Docking-Based Virtual Screening Method to Selection of Natural Compounds with Synergistic Inhibitory Effects Against Cancer Signaling Pathways Using Multi-Target Approach
Background: The complexity of the molecular mechanisms in cancer has led to the ineffectiveness of treatments for many yea...
A meta-analysis of transcriptome data to investigate the effect of soy isoflavones on breast cancer cell
Abstract Background: Breast cancer ranks as the second highest cause of cancer-linked deaths in women, with varying rates ...
DNA Methyltransferase Inhibition by RG108 Improves Stemness and Multipotential Differentiation of Human Adipose Tissue-derived Stem Cells
Background: DNA methylation plays important roles in regulating various biological processes, including self-renewal, diff...
Intein-based fusion proteins: great tags for the soluble production and convenient purification of recombinant proteins
Accumulation in un-folded and inactive inclusion bodies is a major problem in the recombinant protein expression in E. col...
Recent Advances in Development of Biosensors for Monitoring of Airborne Microorganisms
Background: The early detection of infectious microorganisms is crucial for preventing and controlling the transmission of...
Efficient Induction of Apoptosis in Lung Cancer Cells Using Bismuth Sulfide Nanoparticles
Background: The use of nanomaterial-based radiosensitizers to improve the therapeutic ratio has gained attraction inradiot...
Thymoquinone Nanoparticle Induces Apoptosis and Cell Migration Retardation through Modulating of SUMOylation Process Genes in Breast Cancer Cell Line
Background: Due to the heterogeneity of breast cancer, most advanced-stage patients are resistant to therapy. Disruption o...
Network Cluster Analysis of PPI and Phenotype Ontology for Type 1 Diabetes Mellitus
Background: Our knowledge of Type 1 Diabetes Mellitus (T1DM) etiology is incomplete; however, the pathogenesis ofthe disea...
Recombinant Expression and Functional Assessment of Uricase from a Pertinent Origin of the Enzyme, Streptomyces sp. Strain 17-1
Background: Uricase or urate oxidase, as a therapeutic enzyme, is extensively applied to oxidize accumulated uric acidin t...
Antimicrobial Activity of Chitosan Scaffold Loaded with Soluble Factors of Different Probiotic Strains Against Multidrug Resistant Pseudomonas aeruginosa
Background: Bacterial infection remains the most frequent complication of burn injury, which can lead to sepsis, evenif an...
Beauveria Bassiana Amylase-Polygalacturonase Production Using Lignocellulosic Biomass and Application in Juice Processing
Background: The search for sources of industrial biocatalysts, which are non-pathogenic and can utilise cheap nutrientsour...
Growing Conditions and Varietal Ecologies Differently Regulates the Growth-regulating-factor (GRFs) Gene Family in Rice
Background Growth-regulating factors (GRFs) are crucial in rice for controlling plant growth and development. Amongthe ric...
The Effect of Bacillus Cereus on the Ion Homeostasis, Growth Parameters, and the Expression of Some Genes of Artemisinin Biosynthesis Pathway in Artemisia Absinthium Under Salinity Stress
Background: Soil salinity is a major problem in the world that affects the growth and yield of plants. Application of newa...
Controlling Tomato Fusarium Wilt Disease through Bacillus thuringiensis-Mediated Defense Primining
Background: Fusarium wilt caused by the fungus Fusarium oxysporum f. sp. lycopersici (Fol) (Sacc.) W.C. Snyder andH.N. Han...
Time and Cost-Effective Genome Editing Protocol for Simultaneous Caspase 8 Associated Protein 2 Gene Knock in/out in Chinese Hamster Ovary Cells Using CRISPR-Cas9 System
Background: CHO cells are preferred for producing biopharmaceuticals, and genome editing technologies offeropportunities t...
Identification of a New Compound (4-Fluoro-2-Trifluoromethyl Imidazole) Extracted From a New Halophilic Bacillus aquimaris Strain Persiangulf TA2 Isolated From the Northern Persian Gulf With Broad-Spectrum Antimicrobial Effect
Background: The unique ecosystem of the Persian Gulf has made it a rich source of natural antimicrobial compounds produced...
Molecular identification of Juglans regia endophyte LTL-G3, its antifungal potential and bioactive substances
Background: Endophyte is one of the potential biocontrol agents for inhibiting plant pathogens. However, the mechanisms an...
Enhancement of Essential Oil Production and Expression of Some Menthol Biosynthesis-Related Genes in Mentha piperita Using Cyanobacteria
Background: Mentha piperita L. is one of the most important aromatic crops and is cultivated worldwide for essential oils ...
Green Synthesis of Polylactic acid/Fe3O4@β-Cyclodextrin Nanofibrous Nanocomposite Loaded with Ferulago Angulata Extract as a Novel Nano-biosorbent: Evaluation of Diazinon Removal and Antibacterial Activity
Background: Organophosphate pesticides are one of the most extensively applied insecticides in agriculture. These insectic...
Gene Networks Analysis of Salmonella Typhimurium Reveals New Insights on Key Genes Involved in Response to Low Water Activity
Background: When Salmonella enterica serovar Typhimurium, a foodborne bacterium, is exposed to osmotic stress, cellular ad...
Research on Circular RNA Expression Profiles in the Photoaging Mouse Model
Background: Nude mouse has been widely used to study photoaging induced by long-term chronic UV exposure. Circular RNAs (c...
CRISPR/Cas9-Induced Fam83h knock-out Leads to Impaired Wnt/β-Catenin Pathway and Altered Expression of Tooth Mineralization Genes in Mice
Background: Dental enamel formation is a complex process that is regulated by various genes. One such gene, Family With Se...
Introns and their therapeutic applications in biomedical researches: A Review
Context: Although for a long time, it was thought that intervening sequences (introns) were junk DNA without any function,...
A Comprehensive Review of the Key Characteristics of the Genus Mentha, Natural Compounds and Biotechnological Approaches for the Production of Secondary Metabolites
Context: The genus Mentha is one of the most aromatic and well-known members of the Lamiaceae family. A wide range of bioa...
Optimization of Affinity Chromatography Based on Sepharose 4Bchitin for Rapid Purification of Urtica dioica Agglutinin
Background: Today, numerous antimicrobial and anticancer properties have been reported for plant lectins due to theirabili...
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