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SOX2 Overlapping Transcript (SOX2-OT) enhances the Lung cancer malignancy through interaction with miR-194-5p/SOX5 axis
Background: Lung cancer is one of the most common types of cancer and a leading cause of cancer-related deaths worldwide. ...
Cloning, Prokaryotic Expression and Functional Characterization of nifH Gene from the Associative Nitrogen-fixing Bacteria Klebsiella variicola DX120E
Background: Biological nitrogen fixation (BNF) is a unique mechanism in which microorganisms utilize the nitrogenase enzym...
MiRNA-145-5p restrains malignant behaviors of breast cancer cells via downregulating H2AFX expression
Background: Breast cancer is a prevalent tumor with high aggressiveness among female populations. MiRNA-145-5p plays an im...
In vitro gluten degradation using recombinant Eurygaster integriceps prolyl endoprotease : Implications for Celiac Disease
Background: Celiac disease (CD) is a gluten-sensitive chronic autoimmune enteropathy. A strict life-long gluten-free diet ...
Data-mining of Barley to identify salt stress hub genes, gene expression analysis, and recombinant plasmid construction
Background: Salinity is one of the major abiotic stresses that limit the production and yields of crops worldwide. Objecti...
PPI Identification of immune-related biomarkers in esophageal cancer on the basis of gene co-expression network
Background: The mortality rate of esophageal cancer is on the continuous increase. Fortunately, with the development of im...
Optimization of Affinity Chromatography Based on Sepharose 4B-chitin for Rapid Purification of Urtica dioica Agglutinin
Background: Today, numerous antimicrobial and anticancer properties have been reported for plant lectins due to their abil...
Anti-inflammatory properties of extract of the hairy root of native Portulaca oleracea L. and its effect on some inflammatory genes expression in rat microglial cells
Background: Most herbs play significant roles in the treatment of various diseases. Because dopamine functions in the anti...
Dexmedetomidine suppresses glutamate-stimulated neuronal injury via microRNA-433/Janus kinase 2/Signal transducer and activator of transcription 3 pathway
Objective: To explore the protective action and mechanism of dexmedetomidine (Dex) on HT22. Materials and Methods: Constru...
The Effect of Collagen and Fibrin Hydrogels Encapsulated with Adipose Tissue Mesenchymal Stem Cell Derived Exosomes for Treatment of Spinal Cord Injury (SCI) In A Rat Animal Model
Background: Mesenchymal Stem Cell (MSC) Derived Exosomes (Mscs-DE) Have Been Demonstrated to Be Potential Candidates for T...
Inhibition of NO Production in LPS-Stimulated Primary Rat Glial Cells by Gnidilatimonoein and Extract of Daphne mucronata
Background: In the CNS, glial cells are involved in neuroinflammation and neuropathic pain. The glial cells are activated ...
Multi-Objective Optimization of Copper Bioleaching: Comparative Study of Pure and Co-Cultured Cultivation
Background: Bioleaching is a practical method to recover metals from low-grade mineral sulfides. The most frequent bacteri...
Response Surface Methodology To Optimize The Expression Efficiency Of Recombinant Reteplase
Background: over expression of Reteplase enzyme has already been studies in the periplasmic space of Escherichia coli (E. ...
Isolation, Identification, and Characterization of the Native Yeast Strains from Homemade Cheese to Assess their Eliminating Impact on the Aflatoxin B1 and M1 of the Simulated Gastrointestinal Fluid
Background: The occurrence of aflatoxins in food products is a silent threat to human health worldwide. A range of strateg...
Preparation and Characterization of Crayfish (Astacus leptodactylus) Chitosan with Different Deacetylation Degrees
Background: In this study, chitosan with various deacetylation degrees was extracted from crayfish (Astacus leptodactylus)...
Efficient CRISPR/Cas9-mediated BAX Gene Ablation In CHO Cells To Impair Apoptosis and Enhance Recombinant Protein Production
Background: Despite recent advances in recombinant biotherapeutics production using CHO cells, their productivity remains ...
Pan-cancer analysis reveals SRC may link lipid metabolism and macrophages
Background: SRC is a member of the membrane-associated non-receptor protein tyrosine kinase superfamily. It has been repor...
Inhibition of NO Production in LPS-Stimulated Primary Rat Glia Cells by Gnidilatimonoein and Extract of Daphne Mucronata
Background: Glia cells in the CNS play key roles in neuro-inflammation and neuropathic pain. They are activated upon vario...
Evaluating and Validating Sunflower Reference Genes for Q-PCR Studies Under High Temperature Condition
Background: Q-PCR is the method of choice for PCR- based transcriptomics and validating microarray-based and RNA-seq resul...
Multi-Objective Optimization of Copper Bioleaching From Iran's Meydouk Mine: Comparative Study of Pure And Co-Culture Indigenous Bacterial Strains
Background: Bioleaching is a practical method to recover metals from low-grade mineral sulfides. The most frequent bacteri...
Molecular dynamics simulation of antimicrobial peptide CM15 in Staphylococcus aureus and Escherichia coli model bilayer lipid
Background: In animals and plants, antimicrobial peptides (AMPs) are crucial components of defense mechanisms, as they pla...
Construction of an STK11 mutation and immune-related prognostic prediction model in lung adenocarcinoma
STK11 mutation in LUAD affects immune cell infiltration in tumor tissue. This study aims to construct an STK11 mutation an...
Evaluation of Apoptosis, Cell Proliferation and Cell Cycle Progression by Inactivation of the NEAT1 Long Noncoding RNA in a Renal Carcinoma Cell Line Using CRISPR/Cas9
Background: Long noncoding RNAs (lncRNAs) play an important role in cellular mechanisms including transcription, translati...
Department of Stem Cells and Regenerative Medicine, Institute of Medical Biotechnology, National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran
Background: Troponin T1 (TNNT1) is implicated in human carcinogenesis. However, the role of TNNT1 in ovarian cancer (OC) r...
PIWIL2 Regulates the Proliferation, Apoptosis and ColonyFormation of Colorectal Cancer Cell Line
Background: Tumor cells proliferation and apoptosis inhibition are the mechanisms through which the Colorectal Cancer (CRC...
TNF-α Regulates the Glucocorticoid Receptor Alpha Expression in Human Nasal Epithelial Cells Via p65-NF-κb and p38-MAPK Signaling Pathways
Background: Tumor necrosis factor (TNF)-α induces changes in the glucocorticoid receptor (GR) isoforms’ expression in huma...
Molecular and Phenotypic Responses of Rhizobacteria-Treated Tomato Plants to Tomato Mosaic Virus Under Greenhouse Conditions
Background: Tomato mosaic disease, mainly caused by Tomato mosaic virus (ToMV), is one of the devastating viral diseases w...
Phytate-induced dose-response auto-activation of enzyme in commercial recombinant phytase from Escherichia coli
Background: Microbial phytase is one of the most widely used enzymes in food industries like cattle, poultry, and aquacult...
Insights into the effects of amino acid substitutions on the stability of reteplase structure: a molecular dynamics simulation study
Background: Reteplase (recombinant plasminogen activator, r-PA) is a recombinant protein designed to imitate the endogenou...
Evaluation of Apoptosis, Cell Proliferation and Cell Cycle Progression by degradation of the Long Noncoding RNA NEAT1 in an RCC Cell Line Using CRISPR/Cas9
Background: lncRNAs play an important role in cellular mechanisms, including transcription, translation, and apoptosis. NE...
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