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Identification of a New Compound (4-Fluoro-2-Trifluoromethyl Imidazole) Extracted From a New Halophilic Bacillus aquimaris Strain Persiangulf TA2 Isolated From the Northern Persian Gulf With Broad-Spectrum Antimicrobial Effect
Background: The unique ecosystem of the Persian Gulf has made it a rich source of natural antimicrobial compounds produced...
Molecular identification of Juglans regia endophyte LTL-G3, its antifungal potential and bioactive substances
Background: Endophyte is one of the potential biocontrol agents for inhibiting plant pathogens. However, the mechanisms an...
Enhancement of Essential Oil Production and Expression of Some Menthol Biosynthesis-Related Genes in Mentha piperita Using Cyanobacteria
Background: Mentha piperita L. is one of the most important aromatic crops and is cultivated worldwide for essential oils ...
Green Synthesis of Polylactic acid/Fe3O4@β-Cyclodextrin Nanofibrous Nanocomposite Loaded with Ferulago Angulata Extract as a Novel Nano-biosorbent: Evaluation of Diazinon Removal and Antibacterial Activity
Background: Organophosphate pesticides are one of the most extensively applied insecticides in agriculture. These insectic...
Gene Networks Analysis of Salmonella Typhimurium Reveals New Insights on Key Genes Involved in Response to Low Water Activity
Background: When Salmonella enterica serovar Typhimurium, a foodborne bacterium, is exposed to osmotic stress, cellular ad...
Research on Circular RNA Expression Profiles in the Photoaging Mouse Model
Background: Nude mouse has been widely used to study photoaging induced by long-term chronic UV exposure. Circular RNAs (c...
CRISPR/Cas9-Induced Fam83h knock-out Leads to Impaired Wnt/β-Catenin Pathway and Altered Expression of Tooth Mineralization Genes in Mice
Background: Dental enamel formation is a complex process that is regulated by various genes. One such gene, Family With Se...
Introns and their therapeutic applications in biomedical researches: A Review
Context: Although for a long time, it was thought that intervening sequences (introns) were junk DNA without any function,...
A Comprehensive Review of the Key Characteristics of the Genus Mentha, Natural Compounds and Biotechnological Approaches for the Production of Secondary Metabolites
Context: The genus Mentha is one of the most aromatic and well-known members of the Lamiaceae family. A wide range of bioa...
Optimization of Affinity Chromatography Based on Sepharose 4Bchitin for Rapid Purification of Urtica dioica Agglutinin
Background: Today, numerous antimicrobial and anticancer properties have been reported for plant lectins due to theirabili...
The Effect of Collagen and Fibrin Hydrogels Encapsulated with Adipose Tissue Mesenchymal Stem Cell-Derived Exosomes for Treatment of Spinal Cord Injury in a Rat Model
Background: Mesenchymal stem cell (MSC) derived exosomes (MSC-DE) have been demonstrated to be potential candidates for th...
SOX2 Overlapping Transcript (SOX2-OT) enhances the Lung cancer malignancy through interaction with miR-194-5p/SOX5 axis
Background: Lung cancer is one of the most common types of cancer and a leading cause of cancer-related deaths worldwide. ...
Cloning, Prokaryotic Expression and Functional Characterization of nifH Gene from the Associative Nitrogen-fixing Bacteria Klebsiella variicola DX120E
Background: Biological nitrogen fixation (BNF) is a unique mechanism in which microorganisms utilize the nitrogenase enzym...
MiRNA-145-5p restrains malignant behaviors of breast cancer cells via downregulating H2AFX expression
Background: Breast cancer is a prevalent tumor with high aggressiveness among female populations. MiRNA-145-5p plays an im...
In vitro gluten degradation using recombinant Eurygaster integriceps prolyl endoprotease : Implications for Celiac Disease
Background: Celiac disease (CD) is a gluten-sensitive chronic autoimmune enteropathy. A strict life-long gluten-free diet ...
Data-mining of Barley to identify salt stress hub genes, gene expression analysis, and recombinant plasmid construction
Background: Salinity is one of the major abiotic stresses that limit the production and yields of crops worldwide. Objecti...
PPI Identification of immune-related biomarkers in esophageal cancer on the basis of gene co-expression network
Background: The mortality rate of esophageal cancer is on the continuous increase. Fortunately, with the development of im...
Optimization of Affinity Chromatography Based on Sepharose 4B-chitin for Rapid Purification of Urtica dioica Agglutinin
Background: Today, numerous antimicrobial and anticancer properties have been reported for plant lectins due to their abil...
Anti-inflammatory properties of extract of the hairy root of native Portulaca oleracea L. and its effect on some inflammatory genes expression in rat microglial cells
Background: Most herbs play significant roles in the treatment of various diseases. Because dopamine functions in the anti...
Dexmedetomidine suppresses glutamate-stimulated neuronal injury via microRNA-433/Janus kinase 2/Signal transducer and activator of transcription 3 pathway
Objective: To explore the protective action and mechanism of dexmedetomidine (Dex) on HT22. Materials and Methods: Constru...
The Effect of Collagen and Fibrin Hydrogels Encapsulated with Adipose Tissue Mesenchymal Stem Cell Derived Exosomes for Treatment of Spinal Cord Injury (SCI) In A Rat Animal Model
Background: Mesenchymal Stem Cell (MSC) Derived Exosomes (Mscs-DE) Have Been Demonstrated to Be Potential Candidates for T...
Inhibition of NO Production in LPS-Stimulated Primary Rat Glial Cells by Gnidilatimonoein and Extract of Daphne mucronata
Background: In the CNS, glial cells are involved in neuroinflammation and neuropathic pain. The glial cells are activated ...
Multi-Objective Optimization of Copper Bioleaching: Comparative Study of Pure and Co-Cultured Cultivation
Background: Bioleaching is a practical method to recover metals from low-grade mineral sulfides. The most frequent bacteri...
Response Surface Methodology To Optimize The Expression Efficiency Of Recombinant Reteplase
Background: over expression of Reteplase enzyme has already been studies in the periplasmic space of Escherichia coli (E. ...
Isolation, Identification, and Characterization of the Native Yeast Strains from Homemade Cheese to Assess their Eliminating Impact on the Aflatoxin B1 and M1 of the Simulated Gastrointestinal Fluid
Background: The occurrence of aflatoxins in food products is a silent threat to human health worldwide. A range of strateg...
Preparation and Characterization of Crayfish (Astacus leptodactylus) Chitosan with Different Deacetylation Degrees
Background: In this study, chitosan with various deacetylation degrees was extracted from crayfish (Astacus leptodactylus)...
Efficient CRISPR/Cas9-mediated BAX Gene Ablation In CHO Cells To Impair Apoptosis and Enhance Recombinant Protein Production
Background: Despite recent advances in recombinant biotherapeutics production using CHO cells, their productivity remains ...
Pan-cancer analysis reveals SRC may link lipid metabolism and macrophages
Background: SRC is a member of the membrane-associated non-receptor protein tyrosine kinase superfamily. It has been repor...
Inhibition of NO Production in LPS-Stimulated Primary Rat Glia Cells by Gnidilatimonoein and Extract of Daphne Mucronata
Background: Glia cells in the CNS play key roles in neuro-inflammation and neuropathic pain. They are activated upon vario...
Evaluating and Validating Sunflower Reference Genes for Q-PCR Studies Under High Temperature Condition
Background: Q-PCR is the method of choice for PCR- based transcriptomics and validating microarray-based and RNA-seq resul...
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