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Characterizing the genomic landscape of colorectal cancer
A study published in Nature elucidates the genomic landscape of colorectal cancer (CRC). Researchers performed whole-genom...
Ammonia-induced stress response in liver disease progression and hepatic encephalopathy
Ammonia-induced stress response in liver disease progression and hepatic encephalopathy
Ammonia levels are orchestrated by a series of complex interrelated pathways in which the urea cycle has a central role. L...
Hepatic immune regulation and sex disparities
Hepatic immune regulation and sex disparities
Chronic liver disease is a major cause of morbidity and mortality worldwide. Epidemiology, clinical phenotype and response...
AI-based tool for scoring MASH histology
In a study published in Nature Medicine, researchers report an artificial intelligence (AI)-based digital pathology tool f...
GLP1 agonists: current and future landscape of clinical trials for patients with metabolic dysfunction
GLP1 agonists: current and future landscape of clinical trials for patients with metabolic dysfunction
Guidelines currently recommend organ-specific management of obesity-related complications. Agents that agonize glucagon-li...
Consequences of bathroom restriction on transgender individuals with gastrointestinal conditions in the United States
Consequences of bathroom restriction on transgender individuals with gastrointestinal conditions in the United States
Bathroom ban legislation is increasing throughout the United States, and little is known about the effect on transgender a...
Intestinal organ chips for disease modelling and personalized medicine
Intestinal organ chips for disease modelling and personalized medicine
Alterations in intestinal structure, mechanics and physiology underlie acute and chronic intestinal conditions, many of wh...
Mapping neuroimmune interactions in the gut
Mapping neuroimmune interactions in the gut
New research has mapped neuroimmune interactions in the mouse gut, revealing that TRPV1-expressing nociceptor neurons (inv...
Liver diseases and hepatocellular carcinoma in the Asia-Pacific region: burden, trends, challenges and future directions
Liver diseases and hepatocellular carcinoma in the Asia-Pacific region: burden, trends, challenges and future directions
Globally, nearly half of deaths from cirrhosis and chronic liver diseases (CLD) and three-quarters of deaths from hepatoce...
EPC 2024
From 26–29 June 2024, Nature Reviews Gastroenterology & Hepatology attended the 56th meeting of the European Pancreati...
Risankizumab versus ustekinumab for Crohn’s disease: a phase IIIb study
A multicenter, open-label, controlled phase IIIb clinical trial (SEQUENCE) published in the New England Journal of Medicin...
EASL Congress 2024
In June 2024, Nature Reviews Gastroenterology & Hepatology attended in person the European Association for the Study o...
Metastatic pancreatic cancer and the liver
A recent study in Nature Medicine describes a multi-parametric profile of a pre-metastatic signature using liver biopsy sa...
Author Correction: A roadmap for clinical trials in MASH-related compensated cirrhosis
Liver Unit, Division of Digestive Diseases, Vall d’Hebron University Hospital, Vall d’Hebron Institute of Research (VHIR),...
Cellular and molecular basis of proximal small intestine disorders
Cellular and molecular basis of proximal small intestine disorders
The proximal part of the small intestine, including duodenum and jejunum, is not only dedicated to nutrient digestion and ...
Mother-to-child transmission of hepatitis B: current status and the road forward
Mother-to-child transmission of hepatitis B virus remains a mode of transmission in high-burden regions where there are ga...
Viral hepatitis elimination — time to act
The countdown to the 2030 viral hepatitis elimination goal continues, but time is running out and progress is not keeping ...
Food inequity and insecurity and MASLD: burden, challenges, and interventions
Food inequity and insecurity and MASLD: burden, challenges, and interventions
Liver disease prevalence, severity, outcomes and hepatic risk factors (for example, unhealthy diet) are heavily affected b...
Shifting targets for eosinophilic oesophagitis
Shifting targets for eosinophilic oesophagitis
Two phase III trials of new drugs for eosinophilic oesophagitis (EoE) have been reported in The New England Journal of Med...
Hepatitis E virus: from innate sensing to adaptive immune responses
Hepatitis E virus: from innate sensing to adaptive immune responses
Hepatitis E virus (HEV) infections are a major cause of acute viral hepatitis in humans worldwide. In immunocompetent indi...
Western lifestyle, metaflammation and the cell of origin of colon cancer
Western lifestyle, metaflammation and the cell of origin of colon cancer
Western lifestyles cause a low-grade but chronic and metabolic inflammation (or metaflammation), which might prime committ...
A bloody disgrace — time to change patient safety culture
A bloody disgrace — time to change patient safety culture
After decades of institutional deceit, deflection, defensiveness and delay, publication of the final report of the Infecte...
Incretin-based therapies for liver disease
Incretin-based therapies for liver disease
The beginning of June saw the publication of four trials assessing the efficacy and safety of incretin-based drugs in stea...
Disability inclusion in research and health care
Globally, one in six people have a disability, and individuals with disabilities often experience a narrow margin of healt...
A roadmap for clinical trials in MASH-related compensated cirrhosis
A roadmap for clinical trials in MASH-related compensated cirrhosis
Although metabolic dysfunction-associated steatohepatitis (MASH) is rapidly becoming a leading cause of cirrhosis worldwid...
Fgfbp1+ cells: upper crypt intestinal epithelial regeneration
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obta...
Neoadjuvant immunotherapy for mismatch repair-deficient colon cancer: a phase II study
A multicentre phase II study (NICHE-2; NCT03026140) conducted by the Netherlands Cancer Institute has investigated the saf...
ETS2 regulates human inflammatory macrophages in IBD
New research has identified ETS2 as a central regulator of human inflammatory macrophages. An intergenic region on chr21q2...
Digestive Disease Week 2024
From 18–21 May 2024, Nature Reviews Gastroenterology & Hepatology was back at Digestive Disease Week (DDW) in Washingt...
Intermittent fasting for NASH and HCC in mice
Intermittent fasting for NASH and HCC in mice
A recent study published in Cell Metabolism has investigated the effect of intermittent fasting on nonalcoholic steatohepa...
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