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High-density lipoprotein lipidome: a neglected source of hepatic lipids
To define the pathophysiology of metabolic dysfunction-associated steatotic liver disease (MASLD) and identify therapeutic...
Unlocking CD8+ T cell potential in chronic hepatitis B virus infection
Unlocking CD8+ T cell potential in chronic hepatitis B virus infection
Advances in 2024 have transformed our understanding of CD8+ T cell dysfunction in chronic hepatitis B virus infection, rev...
Transforming the landscape of liver cancer detection and care
Transforming the landscape of liver cancer detection and care
In 2024, important studies highlighted the ongoing global battle against liver cancer, a deadly yet common cancer. Despite...
A new treatment and updated clinical practice guidelines for MASLD
A new treatment and updated clinical practice guidelines for MASLD
The year 2024 was momentous for metabolic dysfunction-associated steatotic liver disease (MASLD): the approval of the firs...
Metabolic health across the ages: how microbiota members support our well-being
Metabolic health across the ages: how microbiota members support our well-being
The microbiota is critical for metabolic health. Studies published in 2024 have revealed mechanisms by which key bacterial...
Transport functions of intestinal lymphatic vessels
Transport functions of intestinal lymphatic vessels
Lymphatic vessels are crucial for fluid absorption and the transport of peripheral immune cells to lymph nodes. However, i...
Probiotics for preterms: sharing complex decision-making
Probiotics for preterms: sharing complex decision-making
Probiotics might prevent some necrotizing enterocolitis, late-onset sepsis and mortality in preterm infants. However, clin...
Gut microbiome: a biomedical revolution
To mark the twentieth anniversary of Nature Reviews Gastroenterology & Hepatology, we asked three experts to comme...
Health disparities in cirrhosis care and liver transplantation
Health disparities in cirrhosis care and liver transplantation
Morbidity and mortality from cirrhosis are substantial and increasing. Health disparities in cirrhosis and liver transplan...
Bitter taste receptors as sensors of gut luminal contents
Bitter taste receptors as sensors of gut luminal contents
Taste is important in the selection of food and is orchestrated by a group of distinct receptors, the taste G protein-coup...
Intestinal tuft cells can act as injury-resistant stem cells
Subsets of human tuft cells retain their proliferative capacity throughout life and can act as a damage-induced pool of re...
Alcohol-free and low-strength drinks: friend or foe?
Consumption of no and low-alcohol (NoLo) beverages is now commonplace in modern society. However, the debate surrounding t...
UEG Week 2024
From 12–15 October, United European Gastroenterology (UEG) Week was held in person in Vienna, Austria, and online simultan...
Bile acid transport inhibitors in paediatric hepatology: more than just an itch
Apical sodium-dependent bile acid transporter inhibitors have revolutionized care for children with genetic cholestasis. T...
Host–pathobiont interactions in Crohn’s disease
Host–pathobiont interactions in Crohn’s disease
The mammalian intestine is colonized by trillions of microorganisms that are collectively referred to as the gut microbiot...
Celebrating 20 years of Nature Reviews Gastroenterology & Hepatology
Celebrating 20 years of Nature Reviews Gastroenterology & Hepatology
Twenty years since the launch of Nature Reviews Gastroenterology & Hepatology, developments in research and clinic...
Delving the depths of ‘terra incognita’ in the human intestine — the small intestinal microbiota
Delving the depths of ‘terra incognita’ in the human intestine — the small intestinal microbiota
The small intestinal microbiota has a crucial role in gastrointestinal health, affecting digestion, immune function, bile ...
Actions of thyroid hormones and thyromimetics on the liver
Actions of thyroid hormones and thyromimetics on the liver
Thyroid hormones (triiodothyronine and thyroxine) are pivotal for metabolic balance in the liver and entire body. Dysregul...
Author Correction: Classifying compounds as prebiotics — scientific perspectives and recommendations
Authors and AffiliationsUniversity of Nebraska, Lincoln, NE, USARobert HutkinsUniversity College Cork, Cork, IrelandJens W...
An expert panel Consensus Statement on ALD without experts by experience
We fully support the consensus statement on designing clinical trials to address alcohol use in peopl...
Liraglutide treatment in children with obesity
A phase IIIa trial tested the safety and efficacy of liraglutide, a glucagon-like peptide 1 receptor agonist, in 82 childr...
Liver transplantation plus chemotherapy improved survival in patients with colorectal liver metastasis
A multicentre, open-label, prospective, randomized controlled trial (TransMet) assessed liver transplantation plus chemoth...
Anticoagulants in cirrhosis: main concerns
Management of anticoagulation in cirrhosis is challenging because of the concomitant risk of both thromboembolism and blee...
Interpreting modern randomized controlled trials of medical therapy in inflammatory bowel disease
Interpreting modern randomized controlled trials of medical therapy in inflammatory bowel disease
Treatment options for the medical management of inflammatory bowel disease (IBD) have expanded substantially over the past...
Digital twins are integral to personalizing medicine and improving public health
Digital twins are integral to personalizing medicine and improving public health
Digital twins provide a framework to advance the field of personalized medicine by generating clinically actionable strate...
Author Correction: Hepatic immune regulation and sex disparities
These authors contributed equally: Patrizia Burra, Alberto Zanetto.Gastroenterology and Multivisceral Transplant Unit, Dep...
Therapy affects tumour microenvironment in pancreatic cancer
New research published in Nature Genetics shows how neoadjuvant chemotherapy and radiotherapy affect the tumour microenvir...
MASLD: a disease in flux
To coincide with the 20th anniversary of Nature Reviews Gastroenterology & Hepatology, we asked three experts to r...
Dietary and metabolic effects on intestinal stem cells in health and disease
Dietary and metabolic effects on intestinal stem cells in health and disease
Diet and nutritional metabolites exhibit wide-ranging effects on health and disease partly by altering tissue composition ...