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Antibiotic-perturbed microbiota and the role of probiotics
Antibiotic-perturbed microbiota and the role of probiotics
The disruptive effect of antibiotics on the composition and function of the human microbiota is well established. However,...
Immune-mediated liver injury from checkpoint inhibitors: mechanisms, clinical characteristics and management
Immune-mediated liver injury from checkpoint inhibitors: mechanisms, clinical characteristics and management
Immunotherapy has changed the treatment landscape for patients with cancer in the past decade. Immune checkpoint ...
Precision models in hepatocellular carcinoma
Precision models in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) represents a global health challenge, and ranks among one of the most prevalent and deadlie...
Biologic agents for IBD come of age as host–microbe interactions emerge
Biologic agents for IBD come of age as host–microbe interactions emerge
In 2024, there were major advances in inflammatory bowel disease research. Treatment strategies with biologic agents for i...
Current and emerging strategies for the prevention of hepatocellular carcinoma
Current and emerging strategies for the prevention of hepatocellular carcinoma
Liver cancer is the third leading cause of cancer-related deaths globally, with incident cases expected to rise from 905,7...
The steatotic liver disease burden paradox: unravelling the key role of alcohol
The steatotic liver disease burden paradox: unravelling the key role of alcohol
The classification of steatotic liver disease (SLD) has evolved, incorporating all conditions characterized by hepatic lip...
Moving towards more personalized approaches in locally advanced and metastatic colorectal cancer
Colorectal cancer remains a challenging heterogeneous disease with substantial morbidity and mortality. However, progressi...
Hepatic vagus nerve relays signals to the brain that can alter food intake
Desynchrony of the mammalian circadian clock has known detrimental metabolic effects, but how synchronous and desynchronou...
Non-canonical metastatic colorectal cancer
A new study published in Nature explores the dynamic changes that colorectal cancer (CRC) cells undergo during their trans...
The ins and outs of tumour resistance
New research published in Science Translational Medicine identifies an interplay between tumour-intrinsic and tumour-extri...
The gut–brain axis and pain signalling mechanisms in the gastrointestinal tract
The gut–brain axis and pain signalling mechanisms in the gastrointestinal tract
Visceral pain is a major clinical problem and one of the most common reasons patients with gastrointestinal disorders seek...
High-density lipoprotein lipidome: a neglected source of hepatic lipids
To define the pathophysiology of metabolic dysfunction-associated steatotic liver disease (MASLD) and identify therapeutic...
Unlocking CD8+ T cell potential in chronic hepatitis B virus infection
Unlocking CD8+ T cell potential in chronic hepatitis B virus infection
Advances in 2024 have transformed our understanding of CD8+ T cell dysfunction in chronic hepatitis B virus infection, rev...
Transforming the landscape of liver cancer detection and care
Transforming the landscape of liver cancer detection and care
In 2024, important studies highlighted the ongoing global battle against liver cancer, a deadly yet common cancer. Despite...
A new treatment and updated clinical practice guidelines for MASLD
A new treatment and updated clinical practice guidelines for MASLD
The year 2024 was momentous for metabolic dysfunction-associated steatotic liver disease (MASLD): the approval of the firs...
Metabolic health across the ages: how microbiota members support our well-being
Metabolic health across the ages: how microbiota members support our well-being
The microbiota is critical for metabolic health. Studies published in 2024 have revealed mechanisms by which key bacterial...
Transport functions of intestinal lymphatic vessels
Transport functions of intestinal lymphatic vessels
Lymphatic vessels are crucial for fluid absorption and the transport of peripheral immune cells to lymph nodes. However, i...
Probiotics for preterms: sharing complex decision-making
Probiotics for preterms: sharing complex decision-making
Probiotics might prevent some necrotizing enterocolitis, late-onset sepsis and mortality in preterm infants. However, clin...
Gut microbiome: a biomedical revolution
To mark the twentieth anniversary of Nature Reviews Gastroenterology & Hepatology, we asked three experts to comme...
Health disparities in cirrhosis care and liver transplantation
Health disparities in cirrhosis care and liver transplantation
Morbidity and mortality from cirrhosis are substantial and increasing. Health disparities in cirrhosis and liver transplan...
Bitter taste receptors as sensors of gut luminal contents
Bitter taste receptors as sensors of gut luminal contents
Taste is important in the selection of food and is orchestrated by a group of distinct receptors, the taste G protein-coup...
Intestinal tuft cells can act as injury-resistant stem cells
Subsets of human tuft cells retain their proliferative capacity throughout life and can act as a damage-induced pool of re...
Alcohol-free and low-strength drinks: friend or foe?
Consumption of no and low-alcohol (NoLo) beverages is now commonplace in modern society. However, the debate surrounding t...
UEG Week 2024
From 12–15 October, United European Gastroenterology (UEG) Week was held in person in Vienna, Austria, and online simultan...
Bile acid transport inhibitors in paediatric hepatology: more than just an itch
Apical sodium-dependent bile acid transporter inhibitors have revolutionized care for children with genetic cholestasis. T...
Host–pathobiont interactions in Crohn’s disease
Host–pathobiont interactions in Crohn’s disease
The mammalian intestine is colonized by trillions of microorganisms that are collectively referred to as the gut microbiot...
Celebrating 20 years of Nature Reviews Gastroenterology & Hepatology
Celebrating 20 years of Nature Reviews Gastroenterology & Hepatology
Twenty years since the launch of Nature Reviews Gastroenterology & Hepatology, developments in research and clinic...
Delving the depths of ‘terra incognita’ in the human intestine — the small intestinal microbiota
Delving the depths of ‘terra incognita’ in the human intestine — the small intestinal microbiota
The small intestinal microbiota has a crucial role in gastrointestinal health, affecting digestion, immune function, bile ...
Actions of thyroid hormones and thyromimetics on the liver
Actions of thyroid hormones and thyromimetics on the liver
Thyroid hormones (triiodothyronine and thyroxine) are pivotal for metabolic balance in the liver and entire body. Dysregul...
Author Correction: Classifying compounds as prebiotics — scientific perspectives and recommendations
Authors and AffiliationsUniversity of Nebraska, Lincoln, NE, USARobert HutkinsUniversity College Cork, Cork, IrelandJens W...
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