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Evolving therapeutic landscape of advanced hepatocellular carcinoma
Evolving therapeutic landscape of advanced hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is one of the most common solid malignancies worldwide. A large proportion of patients with...
Artificial intelligence and automation in endoscopy and surgery
Artificial intelligence and automation in endoscopy and surgery
Modern endoscopy relies on digital technology, from high-resolution imaging sensors and displays to electronics connecting...
The microbiota and the gut–liver axis in primary sclerosing cholangitis
The microbiota and the gut–liver axis in primary sclerosing cholangitis
Primary sclerosing cholangitis (PSC) offers unique opportunities to explore the gut–liver axis owing to the close as...
Current developments in gastric cancer: from molecular profiling to treatment strategy
Current developments in gastric cancer: from molecular profiling to treatment strategy
Gastric cancer and gastro-oesophageal junction cancer represent a global health-care challenge. Despite the efficacy of im...
Follow-up of SER-109 for recurrent C. difficile
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Colonoscopy screening and risk of CRC
In a trial to assess the effects of population-based colonoscopy screening on risks of colorectal cancer (CRC), participan...
Investigating two versus three doses of mRNA vaccine in patients with cirrhosis
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Integrated systems approach to identify environmental factors in intestinal inflammation
Environmental factors have an effect on the onset and progression of inflammatory bowel disease (IBD). A new study publish...
Stopped clock promotes fibrosis in chronic pancreatitis
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Mechanisms of pruritus in cholestasis: understanding and treating the itch
Mechanisms of pruritus in cholestasis: understanding and treating the itch
Pruritus in cholestatic liver diseases can be a major burden and dramatically impair the quality of life of those affected...
Colonization of the inflamed intestine by an oral bacterium
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Mechanisms and clinical management of eosinophilic oesophagitis: an overview
Mechanisms and clinical management of eosinophilic oesophagitis: an overview
Since the first description of eosinophilic oesophagitis (EoE) less than three decades ago, we have observed a striking in...
Antibiotics in the pathogenesis of diabetes and inflammatory diseases of the gastrointestinal tract
Antibiotics in the pathogenesis of diabetes and inflammatory diseases of the gastrointestinal tract
Antibiotic use is increasing worldwide. However, the use of antibiotics is clearly associated with changes in gut microbio...
Global epidemiology of alcohol-associated cirrhosis and HCC: trends, projections and risk factors
Global epidemiology of alcohol-associated cirrhosis and HCC: trends, projections and risk factors
Heavy alcohol consumption is a major cause of morbidity and mortality. Globally, alcohol per-capita consumption rose from ...
Gut microbiota in COVID-19: key microbial changes, potential mechanisms and clinical applications
Gut microbiota in COVID-19: key microbial changes, potential mechanisms and clinical applications
The gastrointestinal tract is involved in coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome ...
Enteric neurons and gut homeostasis
Enteric neurons and gut homeostasis
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Nomenclature of HBV core protein-targeting antivirals
Nomenclature of HBV core protein-targeting antivirals
Hepatitis B virus (HBV) core protein-targeting compounds are in or entering clinical development without a standardized no...
Women in endoscopy: leading the way
Women in endoscopy: leading the way
Despite the paucity of women in endoscopy holding leadership roles, inroads are being made as more female endoscopists are...
Elucidating the nutrient preferences of mouse gut bacteria
In a new study published in Cell, researchers have quantified the nutrient preferences of specific gut bacteria in mice. “...
Ultra-processed diet increases CRC risk
A study comprising three USA prospective cohorts (men = 46,341; women = 159,907) examined the association between ultra-pr...
Risk loci in intrahepatic cholestasis of pregnancy
A genome-wide association study and meta-analysis for intrahepatic cholestasis of pregnancy (ICP) that included 1,138 pati...
Robotic surgery for middle and low rectal cancer
A multicentre, randomized, controlled superiority trial (REAL) assessed patients (n = 1,171) with middle and low rectal ca...
Gut–brain axis key to fat preference
Gut–brain axis key to fat preference
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Human duodenal cells contribute to liver regeneration
Analysis of human duodenal submucosal glands (dSGs) isolated from organ donors (n = 32) revealed cells phenotypically dist...
Targeting the endocannabinoid system for the treatment of abdominal pain in irritable bowel syndrome
Targeting the endocannabinoid system for the treatment of abdominal pain in irritable bowel syndrome
The management of visceral pain in patients with disorders of gut–brain interaction, notably irritable bowel syndrom...
Equitable partnerships and the path to inclusive, innovative and impactful human microbiome research
Equitable partnerships and the path to inclusive, innovative and impactful human microbiome research
Practical recommendations on achieving equitability in biomedical research can advance essential efforts to balance resear...
Medical therapy of paediatric inflammatory bowel disease
Antibodies targeting tumour necrosis factor have substantially advanced the treatment of paediatric inflammatory bowel dis...
Nerves in gastrointestinal cancer: from mechanism to modulations
Nerves in gastrointestinal cancer: from mechanism to modulations
Maintenance of gastrointestinal health is challenging as it requires balancing multifaceted processes within the highly co...
Tango of B cells with T cells in the making of secretory antibodies to gut bacteria
Tango of B cells with T cells in the making of secretory antibodies to gut bacteria
Polymeric IgA and IgM are transported across the epithelial barrier from plasma cells in the lamina propria to exert a fun...
Showing a sensitive side
In science as in life, the language we choose to use is of great importance and power. This is particularly true in discus...