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Extracellular vesicles key in liver metastasis
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Combination treatment further extends survival
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A sampling pill to swallow
Ingestible sampling devices have enabled profiling of the intestinal environment and the metabolome at multiple locations ...
AI predicts pancreatic cancer risk
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Antifibrotic therapy in nonalcoholic steatohepatitis: time for a human-centric approach
Antifibrotic therapy in nonalcoholic steatohepatitis: time for a human-centric approach
Nonalcoholic steatohepatitis (NASH) might soon become the leading cause of end-stage liver disease and indication for live...
Irritable bowel syndrome and mental health comorbidity — approach to multidisciplinary management
Irritable bowel syndrome and mental health comorbidity — approach to multidisciplinary management
Irritable bowel syndrome (IBS) affects 5–10% of the global population. Up to one-third of people with IBS also exper...
A Roadmap for the Human Gut Cell Atlas
A Roadmap for the Human Gut Cell Atlas
The number of studies investigating the human gastrointestinal tract using various single-cell profiling methods has incre...
ChatGPT and large language models in gastroenterology
ChatGPT and large language models in gastroenterology
In gastroenterology, ChatGPT and large language models (LLMs) can assist clinicians in various tasks but also have several...
Fetal liver development and implications for liver disease pathogenesis
Fetal liver development and implications for liver disease pathogenesis
The metabolic, digestive and homeostatic roles of the liver are dependent on proper crosstalk and organization of hepatic ...
Nanoparticles in NAFLD therapeutics
Nanoparticles in NAFLD therapeutics
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Etrasimod for ulcerative colitis: evaluating phase III results
Recent clinical trials have demonstrated efficacy and safety of etrasimod, a new sphingosine-1-phosphate receptor modulato...
Elucidating the link between clonal haematopoiesis and chronic liver disease
A new study published in Nature has linked clonal haematopoiesis with an increased risk of chronic liver disease (CLD). Th...
Microbial cues stimulate linear growth in undernourished mice
A new study has found that a strain of the gut bacterium Lactiplantibacillus plantarum activates a NOD2–type I inter...
Gastrointestinal health and the environment: a bidirectional relationship
The health-care sector produces significant amounts of waste and greenhouse gas emissions. In turn, environmental damage c...
Current status of colon capsule endoscopy in clinical practice
Colon capsule endoscopy (CCE) is used for restricted indications only. Growing demand for out-of-hospital treatment combin...
Paracellular permeability and tight junction regulation in gut health and disease
Paracellular permeability and tight junction regulation in gut health and disease
Epithelial tight junctions define the paracellular permeability of the intestinal barrier. Molecules can cross the tight j...
The appendix and ulcerative colitis — an unsolved connection
The appendix and ulcerative colitis — an unsolved connection
The appendix is thought to have a role in the pathogenesis of ulcerative colitis, but the nature and basis of this associa...
NAFLD incidence is increasing
A systematic review and meta-analysis of cohort studies from Mainland China, Hong Kong, South Korea, Japan, Sri Lanka and ...
Zolbetuximab treatment in metastatic gastric cancer
In a placebo-controlled, double-blind, phase III trial, 565 patients with CLDN18.2+HER2– locally advanced unresectable or ...
Combination therapy with methotrexate in paediatric Crohn’s disease
Paediatric patients with Crohn’s disease (n = 297, initiating infliximab or adalimumab, mean age 13.9 years) were randomly...
Air pollution and oesophageal cancer risk
A prospective study of Chinese individuals (n = 510,125) showed that long-term exposure to fine particulate matter (PM2.5)...
Gut–liver axis: barriers and functional circuits
Gut–liver axis: barriers and functional circuits
The gut and the liver are characterized by mutual interactions between both organs, the microbiome, diet and other environ...
Liver fibrosis with methotrexate — an overestimated risk?
Liver fibrosis with methotrexate — an overestimated risk?
A prospective study suggests that the risk of liver fibrosis with methotrexate treatment has been overestimated. The findi...
IL-12 and IL-23 pathway inhibition in inflammatory bowel disease
IL-12 and IL-23 pathway inhibition in inflammatory bowel disease
Interleukin-12 (IL-12) and interleukin-23 (IL-23), which belong to the IL-12 family of cytokines, have a key role in intes...
Macrophages in intestinal homeostasis and inflammatory bowel disease
Macrophages in intestinal homeostasis and inflammatory bowel disease
Macrophages are essential for the maintenance of intestinal homeostasis, yet appear to be drivers of inflammation in the c...
Screening for Barrett oesophagus — a call for collaboration between gastroenterology and primary care
Screening for Barrett oesophagus — a call for collaboration between gastroenterology and primary care
Barrett oesophagus is not detected before its progression to oesophageal adenocarcinoma in over one-half of patients, and ...
Elucidating the transmission landscape of the human microbiome
Elucidating the transmission landscape of the human microbiome
In a study published in Nature, new data have highlighted the bacterial strain-level sharing rates of mother–offspri...
Global burden of hepatitis B virus: current status, missed opportunities and a call for action
Global burden of hepatitis B virus: current status, missed opportunities and a call for action
Chronic hepatitis B virus (HBV) infection affects about 296 million people worldwide and is the leading aetiology of cirrh...
Mutations linked to chemotherapy resistance in colorectal cancer
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Rifaximin-α for ALD: phase II results
In a randomized, double-blind, single-centre, phase II trial, investigators assessed the safety and efficacy of oral rifax...
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