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Cognitive impairment and neurocognitive profiles among people living with HIV and HIV-negative individuals older over 50 years: a comparison of IHDS, MMSE and MoCA
Cognitive impairment and neurocognitive profiles among people living with HIV and HIV-negative individuals older over 50 years: a comparison of IHDS, MMSE and MoCA
We aimed to examine the l differences in the assessment of neurocognitive impairment (NCI) using cognitive screening tools...
Characterization of HIV variants from paired Cerebrospinal fluid and Plasma samples in primary microglia and CD4+ T-cells
Characterization of HIV variants from paired Cerebrospinal fluid and Plasma samples in primary microglia and CD4+ T-cells
Despite antiretroviral therapy (ART), HIV persistence in the central nervous system (CNS) continues to cause a range of co...
Human endogenous retrovirus W in multiple sclerosis: transcriptional activity is associated with decline in oligodendrocyte proportions in the white matter of the brain
Human endogenous retrovirus W in multiple sclerosis: transcriptional activity is associated with decline in oligodendrocyte proportions in the white matter of the brain
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease. One of the basic mechanisms in this disease is th...
Neurological aspects of HTLV-1 infection: symptoms in apparently asymptomatic carriers
Neurological aspects of HTLV-1 infection: symptoms in apparently asymptomatic carriers
Human T-lymphotropic virus type 1 (HTLV-1) is classically associated with the HTLV-1-associated myelopathy/tropical spasti...
Mapping ACE2 and TMPRSS2 co-expression in human brain tissue: implications for SARS-CoV-2 neurological manifestations
Mapping ACE2 and TMPRSS2 co-expression in human brain tissue: implications for SARS-CoV-2 neurological manifestations
The Coronavirus Disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily ...
Modeling HIV-1 infection and NeuroHIV in hiPSCs-derived cerebral organoid cultures
Modeling HIV-1 infection and NeuroHIV in hiPSCs-derived cerebral organoid cultures
The human immunodeficiency virus (HIV) epidemic is an ongoing global health problem affecting 38 million people w...
Clinical characteristics and outcomes of COVID-19-associated encephalopathy in children
Clinical characteristics and outcomes of COVID-19-associated encephalopathy in children
Apart from the typical respiratory symptoms, coronavirus disease 2019 (COVID-19) also affects the central nervous system, ...
Differences in neuroinflammation in people who started antiretroviral treatment during primary versus chronic HIV infection: an 18kDa Translocator protein (TSPO) positron emission tomography (PET) study
Differences in neuroinflammation in people who started antiretroviral treatment during primary versus chronic HIV infection: an 18kDa Translocator protein (TSPO) positron emission tomography (PET) study
Persistent inflammation is described in people with HIV (PWH) on antiretroviral treatment (ART). Early ART initiation is a...
Implications of vascular depression for successful cognitive aging in HIV Disease
Implications of vascular depression for successful cognitive aging in HIV Disease
Although older adults with HIV are at high risk for mild neurocognitive disorders, a subset experience successful cognitiv...
Progressive multifocal leukoencephalopathy associated with systemic lupus erythematosus: longitudinal observation of lymphocytes, JC virus in cerebrospinal fluid, and brain magnetic resonance imaging
Progressive multifocal leukoencephalopathy associated with systemic lupus erythematosus: longitudinal observation of lymphocytes, JC virus in cerebrospinal fluid, and brain magnetic resonance imaging
Progressive multifocal leukoencephalopathy (PML) rarely occurs in patients with systemic lupus erythematosus (SLE). This r...
Cerebrospinal Fluid Biomarkers of Symptomatic Neurosyphilis in People With HIV Compared with Uninfected Individuals
Cerebrospinal Fluid Biomarkers of Symptomatic Neurosyphilis in People With HIV Compared with Uninfected Individuals
We evaluated the diagnostic clinical performance characteristics (DCPC) of cerebrospinal fluid (CSF) total protein (TP), w...
RNA-Seq time-course analysis of neural precursor cell transcriptome in response to herpes simplex Virus-1 infection
RNA-Seq time-course analysis of neural precursor cell transcriptome in response to herpes simplex Virus-1 infection
The neurogenic niches within the central nervous system serve as essential reservoirs for neural precursor cells (NPCs), p...
Tryptophan-kynurenine metabolic pathway and daytime dysfunction in women with HIV
Tryptophan-kynurenine metabolic pathway and daytime dysfunction in women with HIV
Sleep disturbances are prevalent in women with HIV (WWH). Tryptophan-kynurenine (T-K) pathway metabolites are associated w...
Simian varicella virus infection and reactivation in rhesus macaques trigger cytokine and Aβ40/42 alterations in serum and cerebrospinal fluid
Simian varicella virus infection and reactivation in rhesus macaques trigger cytokine and Aβ40/42 alterations in serum and cerebrospinal fluid
Simian varicella virus (SVV) produces peripheral inflammatory responses during varicella (primary infection) and zoster (r...
The synergistic effect of insomnia and depression on risk of herpes zoster
The synergistic effect of insomnia and depression on risk of herpes zoster
Sleep problems was associated with increased risk for herpes zoster (HZ). This study examined subjects with insomnia or a ...
HIV-1 mRNA knockdown with CRISPR/CAS9 enhances neurocognitive function
HIV-1 mRNA knockdown with CRISPR/CAS9 enhances neurocognitive function
Mixed glia are infiltrated with HIV-1 virus early in the course of infection leading to the development of a persistent vi...
Drug-Induced Progressive Multifocal Leukoencephalopathy (PML): A Systematic Review and Meta-Analysis
Drug-Induced Progressive Multifocal Leukoencephalopathy (PML): A Systematic Review and Meta-Analysis
Progressive multifocal leukoencephalopathy (PML) was first described among patients affected by hematological or solid tum...
Fentanyl dysregulates neuroinflammation and disrupts blood-brain barrier integrity in HIV-1 Tat transgenic mice
Fentanyl dysregulates neuroinflammation and disrupts blood-brain barrier integrity in HIV-1 Tat transgenic mice
Opioid overdose deaths have dramatically increased by 781% from 1999 to 2021. In the setting of HIV, opioid drug abuse exa...
Understanding the link between neurotropic viruses, BBB permeability, and MS pathogenesis
Understanding the link between neurotropic viruses, BBB permeability, and MS pathogenesis
Neurotropic viruses can infiltrate the CNS by crossing the blood–brain barrier (BBB) through various mechanisms incl...
SARS-CoV and SARS-CoV-2 display limited neuronal infection and lack the ability to transmit within synaptically connected axons in stem cell–derived human neurons
SARS-CoV and SARS-CoV-2 display limited neuronal infection and lack the ability to transmit within synaptically connected axons in stem cell–derived human neurons
Sarbecoviruses such as SARS and SARS-CoV-2 have been responsible for two major outbreaks in humans, the latter resulting i...
Correction: GP120 and tenofovir alafenamide alter cannabinoid receptor 1 expression in hippocampus of mice
Correction: GP120 and tenofovir alafenamide alter cannabinoid receptor 1 expression in hippocampus of mice
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Meta-analysis of the serum/plasma proteome identifies significant associations between COVID-19 with Alzheimer’s/Parkinson’s diseases
Meta-analysis of the serum/plasma proteome identifies significant associations between COVID-19 with Alzheimer’s/Parkinson’s diseases
In recent years, we have seen the widespread devastations and serious health complications manifested by COVID-19 globally...
Disease Causing Microbes
Disease Causing Microbes
This book provides knowledge on the diversity of disease-causing microbes including bacteria, viruses, fungi and protozoans
Reactivation of varicella zoster virus following trigeminal schwannoma resection
Reactivation of varicella zoster virus following trigeminal schwannoma resection
Varicella zoster is found exclusively in humans. Infected people with this virus result in chickenpox followed by dormant ...
Correction: Performance of the national institute of infectious diseases disability scale in HTLV-1-associated myelopathy/tropical spastic paraparesis
Correction: Performance of the national institute of infectious diseases disability scale in HTLV-1-associated myelopathy/tropical spastic paraparesis
Department of Neurology, Pedro Ernesto University Hospital, the University of the State of Rio de Janeiro, Rio de Janeiro,...
Pembrolizumab for the treatment of progressive multifocal leukoencephalopathy in China
Pembrolizumab for the treatment of progressive multifocal leukoencephalopathy in China
The aim of this study is to analyze the clinical characteristics and outcomes of Chinese patients with progressive multifo...
Genetic polymorphisms in innate immunity genes influence predisposition to tick-borne encephalitis
Genetic polymorphisms in innate immunity genes influence predisposition to tick-borne encephalitis
Tick-borne encephalitis (TBE) is a neuroviral disease that ranges in severity from a mild febrile illness to a severe and ...
Disruption of blood–brain barrier: effects of HIV Tat on brain microvascular endothelial cells and tight junction proteins
Disruption of blood–brain barrier: effects of HIV Tat on brain microvascular endothelial cells and tight junction proteins
Although the widespread use of antiretroviral therapy (ART) has prolonged the life span of people living with HIV (PLWH), ...
Characterizing Epstein-Barr virus infection of the central nervous system in Zambian adults living with HIV
Characterizing Epstein-Barr virus infection of the central nervous system in Zambian adults living with HIV
The significance of Epstein-Barr virus (EBV) detection in the cerebrospinal spinal fluid (CSF) in people living with HIV (...
Changes in Cerebrospinal Fluid, Liver and Intima-media-thickness Biomarkers in Patients with HIV-associated Neurocognitive Disorders Randomized to a Less Neurotoxic Treatment Regimen
Changes in Cerebrospinal Fluid, Liver and Intima-media-thickness Biomarkers in Patients with HIV-associated Neurocognitive Disorders Randomized to a Less Neurotoxic Treatment Regimen
The prevalence of neurocognitive impairment in people living with HIV is estimated between 30 and 50%. The pathogenesis of...
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