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Stimulating intestinal GIP release reduces food intake and body weight in mice
Stimulating intestinal GIP release reduces food intake and body weight in mice
Available online 21 April 2024, 101945Author links open overlay panel, , , , , , , , , , , , Highlights•Dq-DREADD activati...
Microbial metabolite deoxycholic acid-mediated ferroptosis exacerbates high-fat diet-induced colonic inflammation
Microbial metabolite deoxycholic acid-mediated ferroptosis exacerbates high-fat diet-induced colonic inflammation
Available online 18 April 2024, 101944Author links open overlay panel, , , , , , , , , , , Highlights•HFD increased DCA le...
miR-141/200c contributes to ethanol-mediated hepatic glycogen metabolism
miR-141/200c contributes to ethanol-mediated hepatic glycogen metabolism
Available online 18 April 2024, 101942Author links open overlay panel, , , , Highlights•miR-141/200c deficiency rewires he...
LRP1 in GABAergic neurons is a key link between obesity and memory function
LRP1 in GABAergic neurons is a key link between obesity and memory function
Available online 16 April 2024, 101941Author links open overlay panel, , , , , , , , , , , , , , Highlights•GABAergic LRP1...
Tanycytes release glucose using the glucose-6-phosphatase system during hypoglycemia to control hypothalamic energy balance
Tanycytes release glucose using the glucose-6-phosphatase system during hypoglycemia to control hypothalamic energy balance
Available online 17 April 2024, 101940Author links open overlay panel, , , Highlights•Tanycytes express the G6Pase system....
Crosstalk interactions between transcription factors ERRα and PPARα assist PPARα-mediated gene expression
Crosstalk interactions between transcription factors ERRα and PPARα assist PPARα-mediated gene expression
Keywordsnuclear receptornuclear receptor crosstalkPPARαERRαprotein-protein interactiongene regulationcoregulatorPGC1αmouse...
Neuronal E93 is required for adaptation to adult metabolism and behavior
Neuronal E93 is required for adaptation to adult metabolism and behavior
KeywordsMonogenic factor of obesitySystemic metabolic failureExercise enduranceCircadian rhythmNeuronal regulation of feed...
Corrigendum to “Elevation of hypothalamic ketone bodies induces a decrease in energy expenditures and an increase risk of metabolic disorder” [Mol Metab, 83 (2024) 101926]
Corrigendum to “Elevation of hypothalamic ketone bodies induces a decrease in energy expenditures and an increase risk of metabolic disorder” [Mol Metab, 83 (2024) 101926]
Available online 12 April 2024, 101937Author links open overlay panelLionel Carneiro 1 3, Rocco Bernasconi 1, Adriano Bern...
Corrigendum to “Inter-domain tagging implicates caveolin-1 in insulin receptor trafficking and Erk signaling bias in pancreatic beta-cells” [Mol Metab 2016 May; 5 (5): 366–378]
Corrigendum to “Inter-domain tagging implicates caveolin-1 in insulin receptor trafficking and Erk signaling bias in pancreatic beta-cells” [Mol Metab 2016 May; 5 (5): 366–378]
Available online 8 April 2024, 101935Author links open overlay panelTobias Boothe 1, Gareth E. Lim 1, Haoning Cen 1, Søs S...
Hepatic ketone body regulation of renal gluconeogenesis
Hepatic ketone body regulation of renal gluconeogenesis
Available online 9 April 2024, 101934Author links open overlay panel, , , , , , , , , Highlights•Renal gluconeogenic gene ...
Roles and Therapeutic Targeting of Ceramide Metabolism in Cancer
Roles and Therapeutic Targeting of Ceramide Metabolism in Cancer
Available online 9 April 2024, 101936Author links open overlay panel, , AbstractBackgroundCeramides are sphingolipids that...
Ablation of IFNγ in Myeloid Cells Suppresses Liver Inflammation and Fibrogenesis in Mice with Hepatic Small Heterodimer Partner (SHP) Deletion
Ablation of IFNγ in Myeloid Cells Suppresses Liver Inflammation and Fibrogenesis in Mice with Hepatic Small Heterodimer Partner (SHP) Deletion
Available online 6 April 2024, 101932Author links open overlay panel, , , , , , , , , Highlights•Hepatic SHP is required t...
Mesenchymal-specific Alms1 knockout in mice recapitulates metabolic features of Alström Syndrome
Mesenchymal-specific Alms1 knockout in mice recapitulates metabolic features of Alström Syndrome
Available online 6 April 2024, 101933Author links open overlay panel, , , , , , , , Highlights•We tested whether lipotoxic...
Tumoral acidosis promotes adipose tissue depletion by fostering adipocyte lipolysis
Tumoral acidosis promotes adipose tissue depletion by fostering adipocyte lipolysis
Available online 1 April 2024, 101930Author links open overlay panel, , , , , , , , Highlights•Cancer cells exposed to aci...
Tyrosine-phosphorylated DNER sensitizes insulin signaling in hepatic gluconeogenesis by inducing proteasomal degradation of TRB3
Tyrosine-phosphorylated DNER sensitizes insulin signaling in hepatic gluconeogenesis by inducing proteasomal degradation of TRB3
BackgroundHepatic insulin resistance, which leads to increased hepatic gluconeogenesis, is a major contributor to fasting ...
Elevation of hypothalamic ketone bodies induces a decrease in energy expenditures and an increase risk of metabolic disorder
Elevation of hypothalamic ketone bodies induces a decrease in energy expenditures and an increase risk of metabolic disorder
ObjectiveKetone bodies (such as β-hydroxybutyrate or BHB) have been recently proposed as signals involved in brain regulat...
Identification of a chromatin-bound ERRα interactome network in mouse liver
Identification of a chromatin-bound ERRα interactome network in mouse liver
ObjectivesEstrogen-related-receptor α (ERRα) plays a critical role in the transcriptional regulation of cellular bioenerge...
Salubrinal promotes phospho-eIF2α-dependent activation of UPR leading to autophagy-mediated attenuation of iron-induced insulin resistance
Salubrinal promotes phospho-eIF2α-dependent activation of UPR leading to autophagy-mediated attenuation of iron-induced insulin resistance
Available online 26 March 2024, 101921Author links open overlay panel, , , , , , Highlights•iron overload induced ER stres...
GLP-1R signaling modulates colonic energy metabolism, goblet cell number and survival in the absence of gut microbiota
GLP-1R signaling modulates colonic energy metabolism, goblet cell number and survival in the absence of gut microbiota
Available online 21 March 2024, 101924Author links open overlay panel, , , , , , , Highlights•Deletion of GLP-1R in germ-f...
Histone lactylation in macrophages is predictive for gene expression changes during ischemia induced-muscle regeneration
Histone lactylation in macrophages is predictive for gene expression changes during ischemia induced-muscle regeneration
Available online 22 March 2024, 101923Author links open overlay panel, , , , Highlights•Macrophages recruited to the injur...
Response to Letter-to-the-editor: “Acetyl-CoA synthetase (ACSS2) does not generate butyryl- and crotonyl-CoA”
Response to Letter-to-the-editor: “Acetyl-CoA synthetase (ACSS2) does not generate butyryl- and crotonyl-CoA”
Cookies are used by this site. Cookie SettingsAll content on this site: Copyright © 2024 Elsevier B.V., its licensors, an...
Letter-to-the-editor on “Acetyl-CoA synthetase (ACSS2) does not generate butyryl- and crotonyl-CoA”
Letter-to-the-editor on “Acetyl-CoA synthetase (ACSS2) does not generate butyryl- and crotonyl-CoA”
Cookies are used by this site. Cookie SettingsAll content on this site: Copyright © 2024 Elsevier B.V., its licensors, an...
A practical and robust method to evaluate metabolic fluxes in primary pancreatic islets
A practical and robust method to evaluate metabolic fluxes in primary pancreatic islets
Keywordsmitochondrial respirationoxidative phosphorylationoxygen consumptionpancreatic isletsAbbreviationsKATPATP-sensitiv...
Corrigendum to “Beta cell specific cannabinoid 1 receptor deletion counteracts progression to hyperglycemia in non-obese diabetic mice” [Mol Metab 82 (2024 April) 101906]
Corrigendum to “Beta cell specific cannabinoid 1 receptor deletion counteracts progression to hyperglycemia in non-obese diabetic mice” [Mol Metab 82 (2024 April) 101906]
Available online 16 March 2024, 101917Author links open overlay panelKanikkai Raja Aseer 1 2, Caio Henrique Mazucanti 1, J...
Intestinal Acyl-CoA Synthetase 5 (ACSL5) Deficiency Potentiates Postprandial GLP-1 & PYY Secretion, Reduces Food Intake, and Protects Against Diet-Induced Obesity
Intestinal Acyl-CoA Synthetase 5 (ACSL5) Deficiency Potentiates Postprandial GLP-1 & PYY Secretion, Reduces Food Intake, and Protects Against Diet-Induced Obesity
ObjectiveIn the small intestine, the products of digestion of dietary triacylglycerol (TAG), fatty acids (FA) and monoacyl...
Scd1 and monounsaturated lipids are required for autophagy and survival of adipocytes
Scd1 and monounsaturated lipids are required for autophagy and survival of adipocytes
Exposure of adipocytes to 'cool' temperatures often found in the periphery of the body induces expression of Stearoyl-CoA ...
Loss of GIPR in LEPR cells impairs glucose control by GIP and GIP:GLP-1 co-agonism without affecting body weight and food intake in mice
Loss of GIPR in LEPR cells impairs glucose control by GIP and GIP:GLP-1 co-agonism without affecting body weight and food intake in mice
Available online 14 March 2024, 101915Author links open overlay panel, , , , , , , , , , , , , , , , , , , …Highlights•Die...
Maternal Exercise Preserves Offspring Cardiovascular Health via Oxidative Regulation of the Ryanodine Receptor
Maternal Exercise Preserves Offspring Cardiovascular Health via Oxidative Regulation of the Ryanodine Receptor
Available online 11 March 2024, 101914Author links open overlay panel, , , , , , , , , , , , , , Highlights•Maternal exerc...
Mustn1 is a smooth muscle cell-secreted microprotein that modulates skeletal muscle extracellular matrix composition
Mustn1 is a smooth muscle cell-secreted microprotein that modulates skeletal muscle extracellular matrix composition
ObjectiveSkeletal muscle plasticity and remodeling are critical for adapting tissue function to use, disuse, and regenerat...
Adipose Tissue Peroxisomal Lipid Synthesis Orchestrates Obesity and Insulin Resistance through LXR-Dependent Lipogenesis
Adipose Tissue Peroxisomal Lipid Synthesis Orchestrates Obesity and Insulin Resistance through LXR-Dependent Lipogenesis
Adipose tissue mass is maintained by a balance between lipolysis and lipid storage. The contribution of adipose lipogenesi...
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