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PGC-1β modulates catabolism and fiber atrophy in the fasting-response of specific skeletal muscle beds
ObjectiveSkeletal muscle is a pivotal organ for the coordination of systemic metabolism, constituting one of the largest s...
Insulin and IGF-1 elicit robust transcriptional regulation to modulate autophagy in astrocytes
ObjectiveInsulin is a principal metabolic hormone. It regulates a plethora of metabolic pathways in peripheral tissues. Th...
T3 and glucose increase expression of phosphoenolpyruvate carboxykinase (PCK1) leading to increased β-cell proliferation
ObjectivesThyroid hormone (T3) and high glucose concentrations are critical components of β-cell maturation and function. ...
Repression of the iron exporter ferroportin may contribute to hepatocyte iron overload in individuals with type 2 diabetes
ObjectiveHyperferremia and hyperferritinemia are observed in patients and disease models of type 2 diabetes mellitus (T2DM...
Discovery of a potent GIPR peptide antagonist that is effective in rodent and human systems
ObjectiveGlucose-dependent insulinotropic polypeptide (GIP) is one of the two major incretin factors that regulate metabol...
Exercise-induced specialized proresolving mediators stimulate AMPK phosphorylation to promote mitochondrial respiration in macrophages
ObjectivePhysical activity has been shown to reduce the risk of CVD mortality in large-cohort longitudinal studies; howeve...
The conversion of β-carotene to vitamin A in adipocytes drives the anti-obesogenic effects of β-carotene in mice
ObjectiveThe β-carotene oxygenase 1 (BCO1) is the enzyme responsible for the cleavage of β-carotene to retinal, the first ...
Glucagon receptor antagonism impairs and glucagon receptor agonism enhances triglycerides metabolism in mice
Volume 66, December 2022, 101639Author links open overlay panelHighlights•Glucagon receptor antagonism impairs and agonism...
Hypothalamic TTF-1 orchestrates the sensitivity of leptin
ObjectiveThyroid transcription factor-1 (TTF-1), a homeodomain-containing transcription factor, is predominantly expressed...
BI 456906: Discovery and preclinical pharmacology of a novel GCGR/GLP-1R dual agonist with robust anti-obesity efficacy
ObjectiveObesity and its associated comorbidities represent a global health challenge with a need for well-tolerated, effe...
A Cre-driver rat model for anatomical and functional analysis of glucagon (Gcg)-expressing cells in the brain and periphery
ObjectiveThe glucagon gene (Gcg) encodes preproglucagon, which is cleaved to form glucagon-like peptide 1 (GLP1) and other...
Single-agent FOXO1 inhibition normalizes glycemia and induces gut β-like cells in streptozotocin-diabetic mice
ObjectivesInsulin treatment remains the sole effective intervention for Type 1 Diabetes. Here, we investigated the therape...
NIK/MAP3K14 in hepatocytes orchestrates NASH to hepatocellular carcinoma progression via JAK2/STAT5 inhibition
ObjectiveNonalcoholic fatty liver disease (NAFLD) ranges from steatosis to nonalcoholic steatohepatitis (NASH), which ofte...
The human batokine EPDR1 regulates β-cell metabolism and function
ObjectiveEpendymin-Related Protein 1 (EPDR1) was recently identified as a secreted human batokine regulating mitochondrial...
ATF5 is a regulator of exercise-induced mitochondrial quality control in skeletal muscle
ObjectivesThe Mitochondrial Unfolded Protein Response (UPRmt) is a compartment-specific mitochondrial quality control (MQC...
Zinc transporter 8 haploinsufficiency protects against beta cell dysfunction in type 1 diabetes by increasing mitochondrial respiration
ObjectiveZinc transporter 8 (ZnT8) is a major humoral target in human type 1 diabetes (T1D). Polymorphic variants of Slc30...
Chemical induction of gut β-like-cells by combined FoxO1/Notch inhibition as a glucose-lowering treatment for diabetes
ObjectiveLifelong insulin replacement remains the mainstay of type 1 diabetes treatment. Genetic FoxO1 ablation promotes e...
Loss of hypothalamic Furin affects POMC to proACTH cleavage and feeding behavior in high-fat diet-fed mice
ObjectiveThe hypothalamus regulates feeding and glucose homeostasis through the balanced action of different neuropeptides...
Elucidating the role of Rgs2 expression in the PVN for metabolic homeostasis in mice
ObjectiveRGS2 is a GTPase activating protein that modulates GPCR-Gα signaling and mice lacking RGS2 globally exhibit metab...
Zmiz1 is required for mature β-cell function and mass expansion upon high fat feeding
ObjectiveIdentifying the transcripts which mediate genetic association signals for type 2 diabetes (T2D) is critical to un...
ROCK1 regulates insulin secretion from β-cells
ObjectiveThe endocrine pancreatic β-cells play a pivotal role in maintaining whole-body glucose homeostasis and its dysreg...
Genetic and environmental circadian disruption induce weight gain through changes in the gut microbiome
Available online 2 November 2022, 101628Highlights•Genetic and environmental circadian disruption desynchronizes intestina...
Chronic cAMP activation induces adipocyte browning through discordant biphasic remodeling of transcriptome and chromatin accessibility
ObjectiveAdipose tissue thermogenesis has been suggested as a new therapeutic target to promote energy metabolism for obes...
Effects of SGLT2 inhibitor dapagliflozin in patients with type 2 diabetes on skeletal muscle cellular metabolism
Volume 66, December 2022, 101620Highlights•Dapagliflozin treatment for 5 weeks increases intramyocellular lipid content in...