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Acetyl-CoA synthetase (ACSS2) does not generate butyryl- and crotonyl-CoA
Acetyl-CoA synthetase (ACSS2) does not generate butyryl- and crotonyl-CoA
Available online 16 February 2024, 101903Author links open overlay panel, , , , , , , , Highlights•No decreased histone bu...
Intermittent rapamycin feeding recapitulates some effects of continuous treatment while maintaining lifespan extension
Intermittent rapamycin feeding recapitulates some effects of continuous treatment while maintaining lifespan extension
Available online 13 February 2024, 101902Author links open overlay panel, , , , , Highlights•Intermittent rapamycin treatm...
Loss of mitochondrial pyruvate carrier 1 supports proline-dependent proliferation and collagen biosynthesis in ovarian cancer
Loss of mitochondrial pyruvate carrier 1 supports proline-dependent proliferation and collagen biosynthesis in ovarian cancer
Available online 13 February 2024, 101900Author links open overlay panel, , , , , , , , , , , , , , Highlights•The PYCR3 g...
Insulin at the Intersection of Thermoregulation and Glucose Homeostasis
Insulin at the Intersection of Thermoregulation and Glucose Homeostasis
Available online 13 February 2024, 101901Author links open overlay panel, , , , , , , Highlights•Energy expenditure and in...
The aryl hydrocarbon receptor in β-cells mediates the effects of TCDD on glucose homeostasis in mice
The aryl hydrocarbon receptor in β-cells mediates the effects of TCDD on glucose homeostasis in mice
ObjectiveChronic exposure to persistent organic pollutants (POPs) is associated with increased incidence of type 2 diabete...
The Vagus Nerve Mediates the Physiological but not Pharmacological Effects of PYY3-36 on Food Intake
The Vagus Nerve Mediates the Physiological but not Pharmacological Effects of PYY3-36 on Food Intake
Available online 8 February 2024, 101895Author links open overlay panel, , , , , , , , , , , , , , , , , , Highlights•A qu...
Treatment of Infantile-Onset Pompe Disease in a Rat Model with Muscle-Directed AAV Gene Therapy
Treatment of Infantile-Onset Pompe Disease in a Rat Model with Muscle-Directed AAV Gene Therapy
Available online 10 February 2024, 101899Author links open overlay panel, , , , , , , , , , , , , , , , , , Highlights•PD ...
NR2F6 is essential for brown adipocyte differentiation and systemic metabolic homeostasis
NR2F6 is essential for brown adipocyte differentiation and systemic metabolic homeostasis
ObjectiveBrown adipose tissue (BAT) development and function are essential for maintaining energy balance. However, the ke...
Lactoylglutathione promotes inflammatory signaling in macrophages through histone lactoylation
Lactoylglutathione promotes inflammatory signaling in macrophages through histone lactoylation
Chronic, systemic inflammation is a pathophysiological manifestation of metabolic disorders. Inflammatory signaling leads ...
Dysfunction of Akt/FoxO3a/Atg7 regulatory loop magnifies obesity-regulated muscular mass decline
Dysfunction of Akt/FoxO3a/Atg7 regulatory loop magnifies obesity-regulated muscular mass decline
Available online 6 February 2024, 101892Author links open overlay panel, , , , , , , , , , , , , , , Highlights•Atg7 is a ...
β-cell Jagged1 is sufficient but not necessary for islet Notch activity and insulin secretory defects in obese mice
β-cell Jagged1 is sufficient but not necessary for islet Notch activity and insulin secretory defects in obese mice
Available online 3 February 2024, 101894Author links open overlay panel, , , , , , , , Highlights•Jagged1 expression track...
The aryl hydrocarbon receptor in β-cells mediates the effects of TCDD on glucose homeostasis in mice
The aryl hydrocarbon receptor in β-cells mediates the effects of TCDD on glucose homeostasis in mice
ObjectiveChronic exposure to persistent organic pollutants (POPs) is associated with increased incidence of type 2 diabete...
All–potassium channel CRISPR screening reveals a lysine-specific pathway of insulin secretion
All–potassium channel CRISPR screening reveals a lysine-specific pathway of insulin secretion
Available online 19 January 2024, 101885Author links open overlay panel, , , , , , , Highlights•Genome-scale CRISPR–Cas9 k...
Brown Adipose Vanin-1 is Required for the Maintenance of Mitochondrial Homeostasis and Prevents Diet-Induced Metabolic Dysfunction
Brown Adipose Vanin-1 is Required for the Maintenance of Mitochondrial Homeostasis and Prevents Diet-Induced Metabolic Dysfunction
Obesity, a chronic disease, is associated with a disruption of the exquisite balance between energy intake and energy expe...
Identification of AgRP cells in the murine hindbrain that drive feeding
Identification of AgRP cells in the murine hindbrain that drive feeding
Available online 19 January 2024, 101886Author links open overlay panel, , , , , , , , , , , , Highlights•AgRP is expresse...
Hepatic Regulator of G protein Signaling 14 Ameliorates NAFLD through Activating cAMP-AMPK Signaling by Targeting Giα1/3
Hepatic Regulator of G protein Signaling 14 Ameliorates NAFLD through Activating cAMP-AMPK Signaling by Targeting Giα1/3
Available online 17 January 2024, 101882Author links open overlay panel, , , , , , , Highlights•Hepatocyte RGS14 protects ...
Permanent Neonatal diabetes-causing Insulin mutations have dominant negative effects on beta cell identity
Permanent Neonatal diabetes-causing Insulin mutations have dominant negative effects on beta cell identity
Available online 16 January 2024, 101879Author links open overlay panel, , , , , , , , , , , Highlights•A stem cell model ...
TAAR1 Agonists Improve Glycemic Control, Reduce Body Weight and Modulate Neurocircuits Governing Energy Balance and Feeding
TAAR1 Agonists Improve Glycemic Control, Reduce Body Weight and Modulate Neurocircuits Governing Energy Balance and Feeding
ObjectiveMetabolic Syndrome, which can be induced or exacerbated by current antipsychotic drugs (APDs), is highly prevalen...
NF1 deficiency drives metabolic reprogramming in ER+ breast cancer
NF1 deficiency drives metabolic reprogramming in ER+ breast cancer
MCF7 RNAseq data is available at Gene Expression Omnibus (GEO) GSE251692, and rat fibroblast, mammary fat pad, and tumor R...
RIPK3 promotes islet amyloid-induced β-cell loss and glucose intolerance in a humanized mouse model of type 2 diabetes
RIPK3 promotes islet amyloid-induced β-cell loss and glucose intolerance in a humanized mouse model of type 2 diabetes
Available online 11 January 2024, 101877Author links open overlay panel, , , , , , , , Highlights•A novel technique was de...
Long non-coding RNA LncCplx2 regulates glucose homeostasis and pancreatic β cell function
Long non-coding RNA LncCplx2 regulates glucose homeostasis and pancreatic β cell function
Available online 11 January 2024, 101878Author links open overlay panel, , , , , , , , , Highlights•LncCplx2 is a rhythmic...
Programming of cardiac metabolism by miR-15b-5p, a miRNA released in cardiac extracellular vesicles following ischemia-reperfusion injury
Programming of cardiac metabolism by miR-15b-5p, a miRNA released in cardiac extracellular vesicles following ischemia-reperfusion injury
ObjectiveWe investigated the potential involvement of miRNAs in the developmental programming of cardiovascular disease CV...
Antibody Blockade of Activin Type II Receptors Preserves Skeletal Muscle Mass and Enhances Fat Loss During GLP-1 Receptor Agonism
Antibody Blockade of Activin Type II Receptors Preserves Skeletal Muscle Mass and Enhances Fat Loss During GLP-1 Receptor Agonism
ObjectiveGlucagon-like peptide 1 (GLP-1) receptor agonists reduce food intake, producing remarkable weight loss in overwei...
Conditional hepatocyte ablation of PDIA1 uncovers indispensable roles in both APOB and MTTP folding to support VLDL secretion
Conditional hepatocyte ablation of PDIA1 uncovers indispensable roles in both APOB and MTTP folding to support VLDL secretion
KeywordsFatty liver diseaseProtein disulfide isomerase A1Microsomal triglyceride transfer proteinProtein foldingUnfolded p...
Two-step regulation by Matrix Gla protein in brown adipose cell differentiation
Two-step regulation by Matrix Gla protein in brown adipose cell differentiation
Bone morphogenetic protein (BMP) signaling is intricately involved in adipose tissue development. BMP7 together with BMP4 ...