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Proline hydroxylase 2 (PHD2) promotes brown adipose thermogenesis by enhancing the hydroxylation of UCP1
Available online 4 June 2023, 101747Author links open overlay panel, , , , , , , , , , , , , , , , , , , …Highlights•PHD2 ...
Maresin 1 activates brown adipose tissue and promotes browning of white adipose tissue in mice
ObjectiveMaresin 1 (MaR1) is a docosahexaenoic acid-derived proresolving lipid mediator with insulin-sensitizing and anti-...
Enhancing de novo ceramide synthesis induced by bisphenol A exposure aggravates metabolic derangement during obesity
ObjectiveExposure to bisphenol A (BPA) has been shown to increase the prevalence of obesity and its related insulin resist...
Rearing mice at 22°C programs increased capacity to respond to chronic exposure to cold but not high fat diet
ObjectiveRodent models raised at environmental temperatures of 21–22 °C are increasingly switched to thermoneutral housing...
Single-cell chromatin accessibility of developing murine pancreas identifies cell state-specific gene regulatory programs
KeywordsPancreatic developmentChromatin accessibilityEndocrine differentiationGene regulatory networksMulti-omic analysisS...
The local GLP-1 system in the olfactory bulb is required for odor-evoked cephalic phase of insulin release in mice
ObjectiveThe olfactory bulb (OB) codes for sensory information and contributes to the control of energy metabolism by regu...
Contribution of the hexosamine biosynthetic pathway in the hyperglycemia-dependent and -independent breakdown of the retinal neurovascular unit
BackgroundDiabetic retinopathy (DR) remains one of the most common complications of diabetes despite great efforts to unco...
Impact of (intestinal) LAL deficiency on lipid metabolism and macrophage infiltration
KeywordsLysosomal acid lipaseLAL-DSmall intestineEnterocytesIntestinal lipid absorptionMacrophagesAbbreviationsLAL KOgloba...
Mechanisms underlying the efficacy of a rodent model of vertical sleeve gastrectomy— a focus on energy expenditure
Background and aimsBariatric surgery remains the only effective and durable treatment option for morbid obesity. Vertical ...
Brain insulin signaling suppresses lipolysis in the absence of peripheral insulin receptors and requires the MAPK pathway
ObjectivesInsulin's ability to counterbalance catecholamine-induced lipolysis defines insulin action in adipose tissue. In...
Semaphorin 4B is an ADAM17-cleaved adipokine that inhibits adipocyte differentiation and thermogenesis
ObjectiveThe metalloprotease ADAM17 (also called TACE) plays fundamental roles in homeostasis by shedding key signaling mo...
Dietary Advanced Glycation End products interacting with the Intestinal Epithelium: what do we really know?
BackgroundAdvanced Glycation End products (AGEs) are a heterogeneous group of stable reaction products formed when amino a...
Interdisciplinary advances reshape the delivery tools for effective NASH treatment
Available online 2 May 2023, 101730Author links open overlay panel, Highlights•Novel membrane antigens specifically mediat...
Diabetes increases mortality in patients with pancreatic and colorectal cancer by promoting cachexia and its associated inflammatory status
ObjectivesCancer is considered an emerging diabetes complication, with higher incidence and worse prognosis in patients wi...
Non-alcoholic Fatty Liver Disease is characterised by a reduced polyunsaturated fatty acid transport via free fatty acids and high-density lipoproteins (HDL)
Background and ObjectivesNon-alcoholic fatty liver disease (NAFLD) develops due to impaired hepatic lipid fluxes and is a ...
Disentangling the effects of obesity and high-fat diet on glucose homeostasis using a photoperiod induced obesity model implicates ectopic fat deposition as a key factor
ObjectiveObesity in laboratory rodents is generally induced by feeding them a high fat diet (HFD). This model does not per...
Twenty-four hour rhythmicity in mitochondrial network connectivity and mitochondrial respiration; a study in human skeletal muscle biopsies of young lean and older individuals with obesity
ObjectiveMitochondrial network dynamics may play role in metabolic homeostasis. Whether mitochondrial network dynamics are...
C/EBPβ-LIP mediated activation of the malate-aspartate shuttle sensitizes cells to glycolysis inhibition
Available online 14 April 2023, 101726Author links open overlay panel, , , , , , , , Highlights•Cellular expression of C/E...
Carboxylesterase 2a deletion provokes hepatic steatosis and insulin resistance in mice involving impaired diacylglycerol and lysophosphatidylcholine catabolism
Available online 12 April 2023, 101725Author links open overlay panel, , , , , , , , , , , , , , , , Highlights•Carboxyles...
Fibroblast Growth Factor-21 is Required for Weight Loss Induced by the Glucagon-like Peptide-1 Receptor Agonist Liraglutide in Male Mice fed High Carbohydrate Diets
KeywordsGlucagon-like peptide-1 receptor agonistsFibroblast Growth Factor-21LiraglutideCarbohydrateFood IntakeWeight LossA...
The GCKR-P446L gene variant predisposes to raised blood cholesterol and lower blood glucose in the P446L mouse-a model for GCKR rs1260326
Available online 7 April 2023, 101722Author links open overlay panel, , , , , , , , , , , Highlights•P446>L substitutio...
An Early, Reversible Cholesterolgenic Etiology of Diet-Induced Insulin Resistance
AktAKT serine/threonine kinaseChIPChromatin immunoprecipitationGFATGlutamine:fructose-6-phosphate amidotransferaseGlcNAcN-...
Aryl Hydrocarbon Receptor Maintains Hepatic Mitochondrial Homeostasis in Mice
Available online 31 March 2023, 101717Author links open overlay panel, , , , , , , , Highlights•AhR has diverse roles in n...
The long-lasting shadow of litter size in rodents: litter size is an underreported variable that strongly determines adult physiology
Background/PurposeLitter size is a biological variable that strongly influences adult physiology in rodents. Despite evide...
Orexin induces the production of an endocannabinoid-derived lysophosphatidic acid eliciting hypothalamic synaptic loss in obesity
Available online 26 March 2023, 101713Author links open overlay panel, , , , , , , , Highlights•Under conditions of chroni...
Neuronal loss of TRPM8 leads to obesity and glucose intolerance in male mice
Available online 24 March 2023, 101714Author links open overlay panel, , , , , , , , , , , , , , Highlights•Chow-fed mice ...
Calponin 2 harnesses metabolic reprogramming to determine kidney fibrosis
Available online 22 March 2023, 101712Author links open overlay panel, , , , , , , , , , , , , , Highlights•Serum CNN2 was...
Ketogenic diets composed of long-chain and medium-chain fatty acids induce cardiac fibrosis in mice
Heart diseases are the leading cause of deaths worldwide. Metabolic interventions via ketogenic diets (KDs) have been used...
The long-lasting shadow of litter size in rodents (Reporting litter size in rodents: A biological variable that strongly determines adult physiology)
Available online 16 March 2023, 101707Author links open overlay panel, , , , , , , , , , , , , Highlights•In rodents, litt...
Inceptor correlates with markers of prostate cancer progression and modulates insulin/IGF1 signaling and cancer cell migration
Available online 15 March 2023, 101706Author links open overlay panel, , , , , , , , , , , Highlights•Inceptor levels corr...
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