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The Glasgow prognostic score predicts survival in patients with advanced non-small cell lung cancer harboring sensitive EGFR mutations who are treated with EGFR tyrosine kinase inhibitors
The Glasgow prognostic score predicts survival in patients with advanced non-small cell lung cancer harboring sensitive EGFR mutations who are treated with EGFR tyrosine kinase inhibitors
Introduction: Epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) are the standard first-line treatm...
Evaluation of cardiac adverse events with ponatinib using a spontaneous reporting database
Evaluation of cardiac adverse events with ponatinib using a spontaneous reporting database
Introduction: The efficacy of ponatinib was demonstrated in patients resistant or intolerant to prior BCR-ABL tyrosine kin...
Risk factors of capecitabine-induced hand-foot syndrome: a single-institution, retrospective study
Risk factors of capecitabine-induced hand-foot syndrome: a single-institution, retrospective study
Introduction: This retrospective study was conducted to identify risk factors for developing hand-foot syndrome (HFS) and ...
Cardiac Adverse Events Associated with Multiple Myeloma Patients Treated with Proteasome Inhibitors
Cardiac Adverse Events Associated with Multiple Myeloma Patients Treated with Proteasome Inhibitors
<b><i>Background:</i></b> Proteasome inhibitors (PIs) are standard treatments for multiple myeloma...
Role of the prognostic nutritional index in predicting survival in advanced hepatocellular carcinoma treated with atezolizumab plus bevacizumab
Role of the prognostic nutritional index in predicting survival in advanced hepatocellular carcinoma treated with atezolizumab plus bevacizumab
Introduction: The prognostic nutritional index (PNI) is a multiparametric score introduced by Onodera based on the blood l...
Malignant primary and metastatic cardiac tumors – a single-center 27-year case review
Malignant primary and metastatic cardiac tumors – a single-center 27-year case review
Background: Malignant primary cardiac tumors are exceedingly rare, and despite surgical exeresis or chemotherapy, their pr...
Impact of relative dose intensity of docetaxel, cisplatin, and 5-fluorouracil neoadjuvant chemotherapy on survival of esophageal squamous cell cancer patients
Impact of relative dose intensity of docetaxel, cisplatin, and 5-fluorouracil neoadjuvant chemotherapy on survival of esophageal squamous cell cancer patients
Introduction. This study aimed to clarify the impact of the average relative dose intensity (RDI) of neoadjuvant chemothe...
Expression of Karyopherin Alpha 2 and Karyopherin Beta 1 Correlate with Poor Prognosis in Gastric Cancer
Expression of Karyopherin Alpha 2 and Karyopherin Beta 1 Correlate with Poor Prognosis in Gastric Cancer
<b><i>Introduction:</i></b> Karyopherin alpha 2 (KPNA2) and karyopherin beta 1 (KPNB1) constitute ...
Eribulin in patients with Liposarcoma and Leiomyosarcoma - a retrospective single center experience
Eribulin in patients with Liposarcoma and Leiomyosarcoma - a retrospective single center experience
Introduction: Soft tissue sarcomas (STS) are rare and heterogenous malignancies with a poor prognosis in advanced disease ...
Simple predictive markers and clinicopathological features of primary liver cancer following HCV clearance with direct-acting antivirals.
Simple predictive markers and clinicopathological features of primary liver cancer following HCV clearance with direct-acting antivirals.
Introduction: Simple predictive markers enabling even non-specialized medical doctors, and clinicopathological features of...
Clinical Significance of Eligibility Criteria Determined by the SPIRITS Trial in Patients with Advanced Gastric Cancer
Clinical Significance of Eligibility Criteria Determined by the SPIRITS Trial in Patients with Advanced Gastric Cancer
Introduction: This study aimed to assess the clinical significance of eligibility criteria determined by phase III clinica...
Recurrence Pattern Comparing Preoperative Chemoradiotherapy and Preoperative Chemotherapy with Docetaxel plus 5-Fluorouracil and Cisplatin for Advanced Esophageal Cancer
Recurrence Pattern Comparing Preoperative Chemoradiotherapy and Preoperative Chemotherapy with Docetaxel plus 5-Fluorouracil and Cisplatin for Advanced Esophageal Cancer
Background. Preoperative chemoradiation therapy (CRT) or chemotherapy (CT) followed by surgery is currently being administ...
MALDI mass spectrometry imaging - Diagnostic pathways and metabolites for renal tumor entities
MALDI mass spectrometry imaging - Diagnostic pathways and metabolites for renal tumor entities
Background: Correct tumor subtyping of primary renal tumors is essential for treatment decision in daily routine. Most of ...
Cyclin Dependent Kinase 9 Inhibition as a Potential Treatment for Hepatocellular Carcinoma
Cyclin Dependent Kinase 9 Inhibition as a Potential Treatment for Hepatocellular Carcinoma
Introduction: Composite cyclin dependent kinase (CDK) inhibition has shown potential as a treatment for hepatocellular car...
Revisiting the Evidence for Routine Transcervical Thymectomy for the Prevention of Thymic Carcinoid Tumours in MEN-1 Patients
Revisiting the Evidence for Routine Transcervical Thymectomy for the Prevention of Thymic Carcinoid Tumours in MEN-1 Patients
Background: Malignant thymic carcinoids are uncommon tumours among patients with multiple-endocrine-neoplasia type-1 (MEN-...
The Glasgow Prognostic Score Predicts Outcomes of Pembrolizumab or Atezolizumab Monotherapy in Patients with Pretreated Non-small Cell Lung Cancer
The Glasgow Prognostic Score Predicts Outcomes of Pembrolizumab or Atezolizumab Monotherapy in Patients with Pretreated Non-small Cell Lung Cancer
Introduction: Predictors of the effectiveness of immune checkpoint inhibitor (ICI) monotherapy in previously treated patie...
The impact of lenvatinib on tumor blood vessel shrinkage of hepatocellular carcinoma during treatment: an imaging-based analysis
The impact of lenvatinib on tumor blood vessel shrinkage of hepatocellular carcinoma during treatment: an imaging-based analysis
Introduction: When lenvatinib is administered to people with hepatocellular carcinoma (HCC), tumor blood flow is reduced d...
Clinical predictor of urinary protein as adverse event associated with atezolizumab plus bevacizumab treatment for unresectable hepatocellular carcinoma
Clinical predictor of urinary protein as adverse event associated with atezolizumab plus bevacizumab treatment for unresectable hepatocellular carcinoma
Background/Aim: Adverse events (AEs) of urinary protein from monoclonal antibodies against vascular endothelial growth fac...
Decision-making among experts in advanced Hodgkin Lymphoma
Decision-making among experts in advanced Hodgkin Lymphoma
Background: In the treatment of advanced Hodgkin Lymphoma (aHL), based on guidelines a multitude of treatment options are ...
PROX1 was associated with LGR5 and Wnt signaling and contributed to poor prognosis in gastric cancer
PROX1 was associated with LGR5 and Wnt signaling and contributed to poor prognosis in gastric cancer
Introduction: We investigated prospero homeobox protein-1 (PROX1) expression in gastric cancer (GC) as a prognostic marker...
Factors, including clinical trial eligibility, associated with induction of third-line treatment for advanced gastric cancer
Factors, including clinical trial eligibility, associated with induction of third-line treatment for advanced gastric cancer
Introduction: Third-line chemotherapy has been suggested to improve survival in patients with gastric cancer. This study a...
SARS CoV-2 virus in cancer patients: a new unknown in an unsolved equation
SARS CoV-2 virus in cancer patients: a new unknown in an unsolved equation
Introduction: Cancer patients are more susceptible to infections and infection can be more severe than in patients withou...
Formin like 2 is a potential biomarker of poor prognosis in nasopharyngeal carcinoma
Formin like 2 is a potential biomarker of poor prognosis in nasopharyngeal carcinoma
Introduction: Nasopharyngeal carcinoma (NPC) is the most common malignant tumor in southern China and Southeast Asia. Alth...
Effect of Germline MEFV polymorphisms on the prognosis of Japanese children with cancer: A regional analysis
Effect of Germline MEFV polymorphisms on the prognosis of Japanese children with cancer: A regional analysis
Introduction: MEFV is the gene responsible for familial Mediterranean fever (FMF). It encodes pyrin, which controls inflam...
Risk factors for nab-paclitaxel and gemcitabine induced peripheral neuropathy in patients with pancreatic cancer
Risk factors for nab-paclitaxel and gemcitabine induced peripheral neuropathy in patients with pancreatic cancer
Background: Chemotherapy induced peripheral neuropathy (CIPN) is one of the most frequently adverse events observed with t...
Comprehensive analysis of ixazomib-induced adverse events using the Japanese pharmacovigilance database
Comprehensive analysis of ixazomib-induced adverse events using the Japanese pharmacovigilance database
Background: Ixazomib is an orally available proteasome inhibitor for multiple myeloma with adverse effects such as gastroi...
Poor Treatment Outcomes with Second-Line Chemotherapy in Advanced Synovial Sarcoma
Poor Treatment Outcomes with Second-Line Chemotherapy in Advanced Synovial Sarcoma
Introduction: Synovial sarcoma predominantly affects adolescents and young adults. Doxorubicin with or without ifosfamide ...
The Impact of Multidisciplinary Weight Management on Body Weight and Body Mass Composition in Women with Breast Cancer Post-Adjuvant Chemotherapy: A Retrospective Chart Review
The Impact of Multidisciplinary Weight Management on Body Weight and Body Mass Composition in Women with Breast Cancer Post-Adjuvant Chemotherapy: A Retrospective Chart Review
Introduction: Weight gain during chemotherapy for breast cancer is a well-documented adverse effect. The purpose of this s...
Dose Modification of Etoposide plus Platinum in Elderly Patients with Extensive-Disease Small-Cell Lung Cancer
Dose Modification of Etoposide plus Platinum in Elderly Patients with Extensive-Disease Small-Cell Lung Cancer
Background: Elderly patients with extensive-disease small-cell lung cancer (ED-SCLC) have a high risk of chemotherapy toxi...
Pretreatment Positron Emission Tomography with 18F-Fluorodeoxyglucose May Be a Useful New Predictor of Early Progressive Disease following Atezolizumab plus Bevacizumab in Patients with Unresectable Hepatocellular Carcinoma
Pretreatment Positron Emission Tomography with 18F-Fluorodeoxyglucose May Be a Useful New Predictor of Early Progressive Disease following Atezolizumab plus Bevacizumab in Patients with Unresectable Hepatocellular Carcinoma
<b><i>Background and Aims:</i></b> The aim of this study was to identify the utility of 18F-fluoro...
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