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Single-cell transcriptomic insights into chemotherapy-induced remodeling of the osteosarcoma tumor microenvironment
Single-cell transcriptomic insights into chemotherapy-induced remodeling of the osteosarcoma tumor microenvironment
Neoadjuvant chemotherapy serves as an effective strategy for treating osteosarcoma (OS) not only by targeting cancerous ce...
Promising microRNAs in pre-diagnostic serum associated with lung cancer up to eight years before diagnosis: a HUNT study
Promising microRNAs in pre-diagnostic serum associated with lung cancer up to eight years before diagnosis: a HUNT study
Blood biomarkers for early detection of lung cancer (LC) are in demand. There are few studies of the full microRNome in se...
Does autoimmune disease impair the survival of hepatocellular carcinoma patients undergoing liver resection? A multi-institutional observational study
Does autoimmune disease impair the survival of hepatocellular carcinoma patients undergoing liver resection? A multi-institutional observational study
Patients with autoimmune diseases (AD) generally carry an increased risk of developing cancer. However, the effect of AD i...
UBQLN4 promotes the proliferation and invasion of non-small cell lung cancer cell by regulating PI3K/AKT pathway
UBQLN4 promotes the proliferation and invasion of non-small cell lung cancer cell by regulating PI3K/AKT pathway
Ubiquilin-4 (UBQLN4), a member of the ubiquilin family, has received limited attention in cancer research to date. Here, w...
Nasopharyngeal amyloidoma: report of three cases and review of the literature
Nasopharyngeal amyloidoma: report of three cases and review of the literature
Nasopharyngeal amyloidoma is a rare, locally aggressive tumor that has been reported in the English literature in only 38 ...
Homoharringtonine may help improve the outcomes of venetoclax and azacitidine in AML1-ETO positive acute myeloid leukemia
Homoharringtonine may help improve the outcomes of venetoclax and azacitidine in AML1-ETO positive acute myeloid leukemia
T(8;21)(q22;q22.1)/AML1-ETO positive acute myeloid leukemia (AE-AML) is sensitive to conventional chemotherapy with a favo...
Similar genetic profile in early and late stage urothelial tract cancer
Similar genetic profile in early and late stage urothelial tract cancer
Urothelial tract cancer (UTC) ranks as the tenth most prevalent cancer and holds the seventh position in terms of mortalit...
Effects of the subtypes of apolipoprotein E on immune inhibition and prognosis in patients with Hepatocellular Carcinoma
Effects of the subtypes of apolipoprotein E on immune inhibition and prognosis in patients with Hepatocellular Carcinoma
To investigate whether prognosis of patients with hepatocellular carcinoma (HCC) is affected by the abundance and subgroup...
FERMT1 suppression induces anti-tumor effects and reduces stemness in glioma cancer cells
FERMT1 suppression induces anti-tumor effects and reduces stemness in glioma cancer cells
Glioma is a leading cause of mortality worldwide, its recurrence poses a major challenge in achieving effective treatment ...
Efficacy and safety of apatinib plus immune checkpoint inhibitors and transarterial chemoembolization for the treatment of advanced hepatocellular carcinoma
Efficacy and safety of apatinib plus immune checkpoint inhibitors and transarterial chemoembolization for the treatment of advanced hepatocellular carcinoma
The evidence of apatinib plus immune checkpoint inhibitors (ICIs) and transarterial chemoembolization (TACE) for treating ...
Developing a deep learning model for predicting ovarian cancer in Ovarian-Adnexal Reporting and Data System Ultrasound (O-RADS US) Category 4 lesions: A multicenter study
Developing a deep learning model for predicting ovarian cancer in Ovarian-Adnexal Reporting and Data System Ultrasound (O-RADS US) Category 4 lesions: A multicenter study
To develop a deep learning (DL) model for differentiating between benign and malignant ovarian tumors of Ovarian-Adnexal R...
Surgical outcomes of major vascular resection for retroperitoneal liposarcoma from a high‑volume sarcoma center: a propensity score matching analysis
Surgical outcomes of major vascular resection for retroperitoneal liposarcoma from a high‑volume sarcoma center: a propensity score matching analysis
Radical resection of retroperitoneal liposarcoma (RLPS) may necessitate vascular resection and reconstruction. The study w...
ZBTB7A regulates LncRNA HOTAIR-mediated ELAVL1/SOX17 axis to inhibit malignancy and angiogenesis in endometrial carcinoma
ZBTB7A regulates LncRNA HOTAIR-mediated ELAVL1/SOX17 axis to inhibit malignancy and angiogenesis in endometrial carcinoma
Endometrial cancer (EC) is the sixth most frequent cancer in women worldwide and has higher fatality rates. The pathophysi...
Targeting the PI3K/AKT/mTOR pathway offer a promising therapeutic strategy for cholangiocarcinoma patients with high doublecortin-like kinase 1 expression
Targeting the PI3K/AKT/mTOR pathway offer a promising therapeutic strategy for cholangiocarcinoma patients with high doublecortin-like kinase 1 expression
Cholangiocarcinoma (CCA), characterized by high heterogeneity and extreme malignancy, has a poor prognosis. Doublecortin-l...
Complete pathological response to pembrolizumab in pretreated pancreatic acinar cell carcinoma
Complete pathological response to pembrolizumab in pretreated pancreatic acinar cell carcinoma
Therapeutic approach used for pancreatic ductal adenocarcinoma is usually translated also for the rarer acinar counterpart...
Deep learning model based on endoscopic images predicting treatment response in locally advanced rectal cancer undergo neoadjuvant chemoradiotherapy: a multicenter study
Deep learning model based on endoscopic images predicting treatment response in locally advanced rectal cancer undergo neoadjuvant chemoradiotherapy: a multicenter study
Neoadjuvant chemoradiotherapy has been the standard practice for patients with locally advanced rectal cancer. However, th...
LncRNA ZFAS1 regulates ATIC transcription and promotes the proliferation and migration of hepatocellular carcinoma through the PI3K/AKT signaling pathway
LncRNA ZFAS1 regulates ATIC transcription and promotes the proliferation and migration of hepatocellular carcinoma through the PI3K/AKT signaling pathway
Long noncoding RNAs (lncRNAs) exert a significant influence on various cancer-related processes through their intricate in...
Rare tumours of the pancreas: monocentric study
Rare tumours of the pancreas: monocentric study
The biology of rare pancreatic tumours, which differs from that of ductal pancreatic cancer, requires increased attention....
Targeting CD73 limits tumor progression and enhances anti-tumor activity of anti-PD-1 therapy in intrahepatic cholangiocarcinoma
Targeting CD73 limits tumor progression and enhances anti-tumor activity of anti-PD-1 therapy in intrahepatic cholangiocarcinoma
Patients with intrahepatic cholangiocarcinoma (iCCA) respond poorly to immune checkpoint blockades (ICBs). In this study, ...
TRF1 and TRF2: pioneering targets in telomere-based cancer therapy
TRF1 and TRF2: pioneering targets in telomere-based cancer therapy
This article presents an in-depth exploration of the roles of Telomere Repeat-binding Factors 1 and 2 (TRF1 and TRF2), and...
Can blood-based markers predict RECIST progression in non-small cell lung cancer treated with immunotherapy?
Can blood-based markers predict RECIST progression in non-small cell lung cancer treated with immunotherapy?
In this study, we aimed to evaluate the potential of routine blood markers, serum tumour markers and their combination in ...
Liver cancer from the perspective of single-cell sequencing: a review combined with bibliometric analysis
Liver cancer from the perspective of single-cell sequencing: a review combined with bibliometric analysis
Liver cancer (LC) is a prevalent malignancy and a leading cause of cancer-related mortality worldwide. Extensive research ...
LINC00525 enhances ZNF460-regulated CD24 expression through the sponge miR-125a-5p to promote malignant progression of breast cancer
LINC00525 enhances ZNF460-regulated CD24 expression through the sponge miR-125a-5p to promote malignant progression of breast cancer
CD24 is a highly glycosylated glycosylphosphatidylinositol anchored membrane protein that plays an important role in tumor...
Identified γ-glutamyl cyclotransferase (GGCT) as a novel regulator in the progression and immunotherapy of pancreatic ductal adenocarcinoma through multi-omics analysis and experiments
Identified γ-glutamyl cyclotransferase (GGCT) as a novel regulator in the progression and immunotherapy of pancreatic ductal adenocarcinoma through multi-omics analysis and experiments
Pancreatic ductal adenocarcinoma (PDAC) is renowned for its formidable and lethal nature, earning it a notorious reputatio...
New uracil analog as inhibitor/modulator of ABC transporters or/and NF-κB in taxol-resistant MCF-7/Tx cell line
New uracil analog as inhibitor/modulator of ABC transporters or/and NF-κB in taxol-resistant MCF-7/Tx cell line
The global increase in breast cancer cases necessitates ongoing exploration of advanced therapies. Taxol (Tx), an initial ...
TREM1+ tumor-associated macrophages secrete CCL7 to promote hepatocellular carcinoma metastasis
TREM1+ tumor-associated macrophages secrete CCL7 to promote hepatocellular carcinoma metastasis
Tumor-associated macrophages (TAMs) play a critical role in hepatocellular carcinoma (HCC) progression and metastasis. Sys...
MEX3A promotes colorectal cancer migration, invasion and EMT via regulating the Wnt/β-catenin signaling pathway
MEX3A promotes colorectal cancer migration, invasion and EMT via regulating the Wnt/β-catenin signaling pathway
Mex-3 RNA binding family members are well-established to be important in cancer development and progression. However, the ...
Circular RNA circLIFR suppresses papillary thyroid cancer progression by modulating the miR-429/TIMP2 axis
Circular RNA circLIFR suppresses papillary thyroid cancer progression by modulating the miR-429/TIMP2 axis
Circular RNAs (circRNAs) are increasingly recognized for their important roles in various cancers, including papillary thy...
Nab-paclitaxel plus platinum versus paclitaxel plus platinum as first-line therapy in patients with metastatic or recurrent cervical cancer
Nab-paclitaxel plus platinum versus paclitaxel plus platinum as first-line therapy in patients with metastatic or recurrent cervical cancer
This study aimed to assess the efficacy and safety of nanoparticle albumin-bound paclitaxel (nab-paclitaxel) plus platinum...
Enhancing hepatocellular carcinoma management: prognostic value of integrated CCL17, CCR4, CD73, and HHLA2 expression analysis
Enhancing hepatocellular carcinoma management: prognostic value of integrated CCL17, CCR4, CD73, and HHLA2 expression analysis
Hepatocellular carcinoma (HCC) is a critical global health concern, with existing treatments benefiting only a minority of...
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