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Efficacy of sintilimab combined with neoadjuvant chemotherapy and trastuzumab in conversional treatment of locally advanced HER2-positive gastric cancer: case analysis and literature review
Efficacy of sintilimab combined with neoadjuvant chemotherapy and trastuzumab in conversional treatment of locally advanced HER2-positive gastric cancer: case analysis and literature review
Regional lymph nodes that are fixed and fused into clusters or those exhibiting metastases outside the regional lymph node...
Multi-classification of breast cancer pathology images based on a two-stage hybrid network
Multi-classification of breast cancer pathology images based on a two-stage hybrid network
In current clinical medicine, pathological image diagnosis is the gold standard for cancer diagnosis. After pathologists d...
Identification of a novel molecular classification for hepatocellular carcinoma based on disulfideptosis-related genes and its potential prognostic significance
Identification of a novel molecular classification for hepatocellular carcinoma based on disulfideptosis-related genes and its potential prognostic significance
Globally, hepatocellular carcinoma (HCC) is one of the most prevalent and deadly malignant tumors. A recent study proposed...
Natural compounds modulate the mechanism of action of tumour-associated macrophages against colorectal cancer: a review
Natural compounds modulate the mechanism of action of tumour-associated macrophages against colorectal cancer: a review
Colorectal cancer (CRC) exhibits a substantial morbidity and mortality rate, with its aetiology and pathogenesis remain el...
Age differences in the treatment of lung cancer–a cohort study among 42,000 patients from Germany
Age differences in the treatment of lung cancer–a cohort study among 42,000 patients from Germany
We aimed to describe treatment of lung cancer patients in Germany based on health claims data, focusing particularly on di...
Insights into cancer characteristics among SARS-CoV-2 infected hospitalized patients: a comprehensive analysis from the National Clinical Registry for COVID-19
Insights into cancer characteristics among SARS-CoV-2 infected hospitalized patients: a comprehensive analysis from the National Clinical Registry for COVID-19
Cancer outcome is dependent on multiple predetermining factors including cancer, type of cancer and its related factors. T...
CT-defined muscle density as a prognostic factor in multiple myeloma undergoing autologous stem cell therapy: a retrospective single center study
CT-defined muscle density as a prognostic factor in multiple myeloma undergoing autologous stem cell therapy: a retrospective single center study
Skeletal muscle quality assessment can be performed by cross-sectional imaging. Skeletal muscle density (SMD) identified t...
Inhibition of NPC1 suppresses cell proliferation and β-catenin signaling activation of liver cancer
Inhibition of NPC1 suppresses cell proliferation and β-catenin signaling activation of liver cancer
Niemann-Pick Type C1 (NPC1) plays a significant role in the development of liver diseases and liver cancer. Our objective ...
Opportunities and challenges of using circulating tumor DNA to predict lung cancer immunotherapy efficacy
Opportunities and challenges of using circulating tumor DNA to predict lung cancer immunotherapy efficacy
Immune checkpoint inhibitors (ICIs), particularly anti-programmed death 1 (PD-1)/ programmed death ligand 1 (PD-L1) antibo...
The role of gut microbial β-glucuronidases in carcinogenesis and cancer treatment: a scoping review
The role of gut microbial β-glucuronidases in carcinogenesis and cancer treatment: a scoping review
The human gut microbiota influence critical functions including the metabolism of nutrients, xenobiotics, and drugs. Gut m...
Effects of preoperative neoadjuvant chemotherapy on postoperative delirium in patients with gynecological tumor surgery: an observational study
Effects of preoperative neoadjuvant chemotherapy on postoperative delirium in patients with gynecological tumor surgery: an observational study
To investigate whether neoadjuvant chemotherapy (NACT) increases the incidence of postoperative delirium (POD) in patients...
A novel mouse model recapitulating the MMR-defective SCLC subtype uncovers an actionable sensitivity to immune checkpoint blockade
A novel mouse model recapitulating the MMR-defective SCLC subtype uncovers an actionable sensitivity to immune checkpoint blockade
Small cell lung cancer (SCLC) has an extremely poor prognosis. Despite high initial response rates to chemotherapy and mod...
Transformation zone at the vallate papillae: a significant source of papillomavirus infection at the base of the tongue?
Transformation zone at the vallate papillae: a significant source of papillomavirus infection at the base of the tongue?
The aim of this study was to investigate whether the base of the tongue harbours a transformation zone (TZ), i.e., an init...
Prognostic factors in clear cell sarcoma: an analysis of soft tissue sarcoma in 43 cases
Prognostic factors in clear cell sarcoma: an analysis of soft tissue sarcoma in 43 cases
Clear cell sarcoma (CCS) of tendons and aponeuroses and CCS-like malignant gastrointestinal neuroectodermal tumor/sarcoma ...
Bioinformatic and experimental data pertaining to the role of the NLRP3 inflammasome in ovarian cancer
Bioinformatic and experimental data pertaining to the role of the NLRP3 inflammasome in ovarian cancer
The Nod-Like Receptor (NLR) family pyrin domain containing 3 (NLRP3) inflammasome plays a role in regulating inflammatory ...
Five-year overall survival of early- and late-onset colorectal cancer in Medellín, Colombia: a comparative study
Five-year overall survival of early- and late-onset colorectal cancer in Medellín, Colombia: a comparative study
Early-onset colorectal cancer (CRC) (EOCRC, < 50 years) has distinct clinicopathological features from late-o...
Overall survival of patients with KIT-mutant metastatic GIST in the era of multiple kinase inhibitor availability
Overall survival of patients with KIT-mutant metastatic GIST in the era of multiple kinase inhibitor availability
The prognosis of patients with metastatic GIST and imatinib-sensitive primary mutations has significantly improved. Howeve...
Impact of IL-8 on survival after TARE in HCC: a comprehensive investigation and external validation from the SORAMIC trial
Impact of IL-8 on survival after TARE in HCC: a comprehensive investigation and external validation from the SORAMIC trial
In the treatment of hepatocellular carcinoma (HCC) with transarterial radioembolization (TARE), identifying reliable bioma...
Integration of single-cell and spatial transcriptome sequencing identifies CDKN2A as a senescent biomarker in endothelial cells implicating hepatocellular carcinoma malignancy
Integration of single-cell and spatial transcriptome sequencing identifies CDKN2A as a senescent biomarker in endothelial cells implicating hepatocellular carcinoma malignancy
Highly complex tumor microenvironment makes hepatocellular carcinoma (HCC) as one of the most malignant tumors worldwide. ...
Peptide Receptor Radionuclide Therapy and clinical associations with renal and hematological toxicities and survival in patients with neuroendocrine tumors: an analysis from two U.S. medical centers
Peptide Receptor Radionuclide Therapy and clinical associations with renal and hematological toxicities and survival in patients with neuroendocrine tumors: an analysis from two U.S. medical centers
Renal and hematological toxicity are side effects and dose-limiting factors of Peptide Receptor Radionuclide Therapy (PRRT...
Intratumoral and peritumoral radiomics for preoperative prediction of neoadjuvant chemotherapy effect in breast cancer based on 18F-FDG PET/CT
Intratumoral and peritumoral radiomics for preoperative prediction of neoadjuvant chemotherapy effect in breast cancer based on 18F-FDG PET/CT
To investigate the value of 18F-FDG PET/CT-based intratumoral and peritumoral radiomics in predicting the efficacy of neoa...
Prognostic nomogram model based on quantitative metrics of subregions surrounding residual cavity in glioblastoma patients
Prognostic nomogram model based on quantitative metrics of subregions surrounding residual cavity in glioblastoma patients
The hyperintensity area surrounding the residual cavity on postoperative fluid-attenuated inversion recovery (FLAIR) image...
Explainable 18F-FDG PET/CT radiomics model for predicting EGFR mutation status in lung adenocarcinoma: a two-center study
Explainable 18F-FDG PET/CT radiomics model for predicting EGFR mutation status in lung adenocarcinoma: a two-center study
To establish an explainable 18F-FDG PET/CT-derived prediction model to identify EGFR mutation status and subtypes (EGFR wi...
HMGB1/TREM1 crosstalk between heat-injured hepatocytes and macrophages promotes HCC progression after RFA
HMGB1/TREM1 crosstalk between heat-injured hepatocytes and macrophages promotes HCC progression after RFA
Tumor recurrence after radiofrequency ablation (RFA) affects the survival rate of patients and limits its clinical applica...
Dysregulation of SIGLEC1 in non-small cell lung cancer: prognostic implications and immunomodulatory role-a multicenter cohort study
Dysregulation of SIGLEC1 in non-small cell lung cancer: prognostic implications and immunomodulatory role-a multicenter cohort study
To investigate the clinical significance and functional role of SIGLEC1-positive cells in non-small cell lungcancer (NSCLC...
Challenges in the treatment of soft-tissue plasmacytoma: a retrospective analysis of 120 patients with extramedullary multiple myeloma
Challenges in the treatment of soft-tissue plasmacytoma: a retrospective analysis of 120 patients with extramedullary multiple myeloma
Despite the development of novel drugs and the widespread use of hematopoietic cell transplantation, the prognosis of pati...
Association between antithrombotic agents use and hepatocellular carcinoma risk: a two-sample mendelian randomization analysis
Association between antithrombotic agents use and hepatocellular carcinoma risk: a two-sample mendelian randomization analysis
Hepatocellular carcinoma (HCC) is the most common primary liver cancer worldwide. Multiple observational studies demonstra...
Single-cell omics and machine learning integration to develop a polyamine metabolism-based risk score model in breast cancer patients
Single-cell omics and machine learning integration to develop a polyamine metabolism-based risk score model in breast cancer patients
Breast cancer remains the leading malignant neoplasm among women globally, posing significant challenges in terms of treat...
Epigenetic modulation of autophagy pathway by small molecules in colorectal cancer: a systematic review
Epigenetic modulation of autophagy pathway by small molecules in colorectal cancer: a systematic review
Colorectal cancer (CRC) remains a global health challenge with limited treatment success due to drug resistance. Recent re...
Metabolomic profiling of childhood medulloblastoma: contributions and relevance to diagnosis and molecular subtyping
Metabolomic profiling of childhood medulloblastoma: contributions and relevance to diagnosis and molecular subtyping
The incidence of brain tumors among children is second only to acute lymphoblastic leukemia, but the mortality rate of bra...
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