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Comparison of cisplatin and mitomycin C/5-FU as radiosensitisers in the treatment of locally advanced vulvar cancer: results of a retrospective, observational, single-institutional cohort study
Comparison of cisplatin and mitomycin C/5-FU as radiosensitisers in the treatment of locally advanced vulvar cancer: results of a retrospective, observational, single-institutional cohort study
We retrospectively investigated the widely used radiosensitisers cisplatin and mitomycin C/5-fluorouracil (5-FU) in patien...
Association between skin immune-related adverse events (irAEs) and multisystem irAEs during PD-1/PD-L1 inhibitor monotherapy
Association between skin immune-related adverse events (irAEs) and multisystem irAEs during PD-1/PD-L1 inhibitor monotherapy
Patients treated with immune checkpoint inhibitors (ICIs) often develop immune-related adverse events (irAEs) in various o...
Impact of metabolic indices of 18F-fluorodeoxyglucose positron emission tomography/computed tomography on post transplantation recurrence of hepatocellular carcinoma
Impact of metabolic indices of 18F-fluorodeoxyglucose positron emission tomography/computed tomography on post transplantation recurrence of hepatocellular carcinoma
Tumor recurrence is the leading cause of death after liver transplantation in patients with hepatocellular carcinoma. Ther...
Top 10 research priorities in colorectal cancer: results from the Colorectal Cancer Priority-Setting Partnership
Top 10 research priorities in colorectal cancer: results from the Colorectal Cancer Priority-Setting Partnership
Colorectal cancer (CRC) is the third most frequent cause of cancer death in the word. Which aspects of research into CRC s...
Pregnancy may have little influence on ground-glass opacities suspected for lung adenocarcinoma
Pregnancy may have little influence on ground-glass opacities suspected for lung adenocarcinoma
Owing to the popularity of low-dose computed tomography in lung cancer screening, young women spotted with ground-glass op...
Serum lactate dehydrogenase as a novel prognostic factor for patients with primary undifferentiated pleomorphic sarcomas
Serum lactate dehydrogenase as a novel prognostic factor for patients with primary undifferentiated pleomorphic sarcomas
Among soft tissue sarcomas, undifferentiated pleomorphic sarcoma (UPS) has relatively higher potential of recurrence and m...
Distribution of gastrointestinal neuroendocrine tumors in Europe: results from a retrospective cross-sectional study
Distribution of gastrointestinal neuroendocrine tumors in Europe: results from a retrospective cross-sectional study
Gastrointestinal (non-pancreatic) neuroendocrine tumors (GI-NETs) represent a rare but increasingly common tumor entity. P...
Efficacy and security of tumor vaccines for hepatocellular carcinoma: a systemic review and meta-analysis of the last 2 decades
Efficacy and security of tumor vaccines for hepatocellular carcinoma: a systemic review and meta-analysis of the last 2 decades
Tumor vaccines for hepatocellular carcinoma (HCC) is an area of intense interest. Tremendous clinical trials have been con...
SDC4-rs1981429, ATM-rs228590 and biomarkers of breast cancer risk
SDC4-rs1981429, ATM-rs228590 and biomarkers of breast cancer risk
This is a correspondence on published article on SDC4-rs1981429, ATM-rs228590 and biomarkers of breast cancer risk. Confou...
Allele frequency and proportion defined by circulating tumor DNA profiling predict tyrosine kinase inhibitors’ therapeutic outcomes for non-small cell lung cancer
Allele frequency and proportion defined by circulating tumor DNA profiling predict tyrosine kinase inhibitors’ therapeutic outcomes for non-small cell lung cancer
Circulating tumor DNA is more and more accessible for patients who cannot undergo biopsy. No consistent conclusion has bee...
Outcome and prognostic factors in patients undergoing salvage therapy for recurrent esophagogastric cancer after multimodal treatment
Outcome and prognostic factors in patients undergoing salvage therapy for recurrent esophagogastric cancer after multimodal treatment
Perioperative systemic treatment has significantly improved the outcome in locally advanced esophagogastric cancer. Howeve...
Efficacy and safety of sintilimab plus docetaxel in patients with previously treated advanced non-small cell lung cancer: a prospective, single-arm, phase II study in China
Efficacy and safety of sintilimab plus docetaxel in patients with previously treated advanced non-small cell lung cancer: a prospective, single-arm, phase II study in China
Although immune checkpoint inhibitor monotherapy has been used as a second-line treatment in advanced non-small cell lung ...
The interplay between telomeric complex members and BCR::ABL1 oncogenic tyrosine kinase in the maintenance of telomere length in chronic myeloid leukemia
The interplay between telomeric complex members and BCR::ABL1 oncogenic tyrosine kinase in the maintenance of telomere length in chronic myeloid leukemia
Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm characterized by recurrent genetic aberration in leukemic ...
Survival outcomes of patients newly diagnosed with diffuse large B-cell lymphoma: real-world evidence from a German claims database
Survival outcomes of patients newly diagnosed with diffuse large B-cell lymphoma: real-world evidence from a German claims database
Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma with increasing incidence. Althou...
TOP-PIC: a new tool to optimize pharmacotherapy and reduce polypharmacy in patients with incurable cancer
TOP-PIC: a new tool to optimize pharmacotherapy and reduce polypharmacy in patients with incurable cancer
Polypharmacy is a significant problem in patients with incurable cancer and a method to optimize pharmacotherapy in this p...
The significance of spread through air spaces in the prognostic assessment model of stage I lung adenocarcinoma and the exploration of its invasion mechanism
The significance of spread through air spaces in the prognostic assessment model of stage I lung adenocarcinoma and the exploration of its invasion mechanism
Spread through air spaces (STAS) is a crucial invasive mode of lung cancer and has been shown to be associated with early ...
PLVAP protein expression correlated with microbial composition, clinicopathological features, and prognosis of patients with stomach adenocarcinoma
PLVAP protein expression correlated with microbial composition, clinicopathological features, and prognosis of patients with stomach adenocarcinoma
Plasmalemma vesicle-associated protein (PLVAP) is involved in many immune‑related signals; however, its role in stom...
CXC chemokine receptor 4 (CXCR4) blockade in cancer treatment
CXC chemokine receptor 4 (CXCR4) blockade in cancer treatment
CXC chemokine receptor type 4 (CXCR4) is a member of the G protein-coupled receptors (GPCRs) superfamily and is specific f...
Repurposing of triamterene as a histone deacetylase inhibitor to overcome cisplatin resistance in lung cancer treatment
Repurposing of triamterene as a histone deacetylase inhibitor to overcome cisplatin resistance in lung cancer treatment
Cisplatin is the core chemotherapeutic drug used for first-line treatment of advanced non-small cell lung cancer (NSCLC). ...
TIMP-2 as a predictive biomarker in 5-Fu-resistant colorectal cancer
TIMP-2 as a predictive biomarker in 5-Fu-resistant colorectal cancer
This study aims to evaluate the value of tissue inhibitors of MMPs-2 (TIMP-2) to indicate 5-Fluorouracil (5-Fu) resistance...
The evaluation of tumor microenvironment infiltration and the identification of angiogenesis-related subgroups in skin cutaneous melanoma
The evaluation of tumor microenvironment infiltration and the identification of angiogenesis-related subgroups in skin cutaneous melanoma
There are limited studies on the association between angiogenesis-related genes (ARGs) and the predictive risk of melanoma...
Low diffusion capacity predicts poor prognosis in extensive stage small cell lung cancer: a single-center analysis of 10 years
Low diffusion capacity predicts poor prognosis in extensive stage small cell lung cancer: a single-center analysis of 10 years
Poor pulmonary function and chronic obstructive pulmonary disease (COPD) are associated with poorer overall survival (OS) ...
Targeting adipocyte–immune cell crosstalk to control breast cancer progression
Targeting adipocyte–immune cell crosstalk to control breast cancer progression
Adipocytes are crucial components of breast cancer and are involved in regulating the progression, therapeutic efficacy, a...
Neuroendocrine differentiation predicts the therapeutic efficacy of abiraterone and docetaxel as first-line therapy in metastatic castration-resistant prostate cancer
Neuroendocrine differentiation predicts the therapeutic efficacy of abiraterone and docetaxel as first-line therapy in metastatic castration-resistant prostate cancer
We aim to explore the predictive value of neuroendocrine differentiation (NED) in patients with metastatic castration-resi...
Immune checkpoint inhibitor-induced hypophysitis: clinical and biochemical features
Immune checkpoint inhibitor-induced hypophysitis: clinical and biochemical features
Immune checkpoint inhibitors are a very promising novel class of immune response-regulating drugs for cancer treatment. Hy...
Testicular neoplasms: the interrelationships of serum levels of microRNA-371a-3p (M371) and classical tumor markers with histology, clinical staging, and age—a statistical analysis
Testicular neoplasms: the interrelationships of serum levels of microRNA-371a-3p (M371) and classical tumor markers with histology, clinical staging, and age—a statistical analysis
In testicular neoplasms, the interrelationship of elevations of the novel serum tumor marker microRNA-371a-3p (M371) and t...
Heterodimerization of cholecystokinin 1 and cholecystokinin 2 receptors in gallbladder cancer: a new mechanism for carcinogenesis
Heterodimerization of cholecystokinin 1 and cholecystokinin 2 receptors in gallbladder cancer: a new mechanism for carcinogenesis
Cholecystokinin is present in abundance in gallbladder tissue and mediates function through two structurally related recep...
A clinically applicable prediction model for the risk of in-hospital mortality in solid cancer patients admitted to intensive care units with sepsis
A clinically applicable prediction model for the risk of in-hospital mortality in solid cancer patients admitted to intensive care units with sepsis
To develop and validate a user-friendly model to predict the risk of in-hospital mortality in solid cancer patients admitt...
Diagnosis and treatment of MPN in real life: exploratory and retrospective chart review including 960 MPN patients diagnosed with ET or MF in Germany
Diagnosis and treatment of MPN in real life: exploratory and retrospective chart review including 960 MPN patients diagnosed with ET or MF in Germany
The WHO 2016 re-classification of myeloproliferative neoplasms resulted in a separation of essential thrombocythemia (ET) ...
Virtual screening reveals aprepitant to be a potent inhibitor of neutral sphingomyelinase 2: implications in blockade of exosome release in cancer therapy
Virtual screening reveals aprepitant to be a potent inhibitor of neutral sphingomyelinase 2: implications in blockade of exosome release in cancer therapy
Exosomes are membrane-derived nano-vesicles upregulated in pathological conditions like cancer. Therefore, inhibiting thei...
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