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Ginsenoside Rk3 modulates gut microbiota and regulates immune response of group 3 innate lymphoid cells to against colorectal tumorigenesis
Ginsenoside Rk3 modulates gut microbiota and regulates immune response of group 3 innate lymphoid cells to against colorectal tumorigenesis
Available online 21 September 2023Author links open overlay panel, , , , , , , Highlights•1. Ginsenoside Rk3 suppresses co...
Tanshinone II ameliorates energy metabolism dysfunction of pulmonary fibrosis using 13C metabolic flux analysis
Tanshinone II ameliorates energy metabolism dysfunction of pulmonary fibrosis using 13C metabolic flux analysis
Evidence indicates that metabolic reprogramming characterized by the changes in cellular metabolic patterns contributes to...
Targeted metabolomics reveals the aberrant energy status in diabetic peripheral neuropathy and the neuroprotective mechanism of traditional Chinese medicine JinMaiTong
Targeted metabolomics reveals the aberrant energy status in diabetic peripheral neuropathy and the neuroprotective mechanism of traditional Chinese medicine JinMaiTong
Diabetic peripheral neuropathy (DPN) is a common and devastating complication of diabetes, for which effective therapies a...
Anti-inflammatory natural products modulate interleukins and their related signaling markers in inflammatory bowel disease: a systematic review
Anti-inflammatory natural products modulate interleukins and their related signaling markers in inflammatory bowel disease: a systematic review
This review aims to identify in vivo studies investigating the potential of plant substances and their natural molecules i...
Push forward LC-MS-based Therapeutic Drug Monitoring and Pharmacometabolomics for Anti-Tuberculosis Precision Dosing and Comprehensive Clinical Management
Push forward LC-MS-based Therapeutic Drug Monitoring and Pharmacometabolomics for Anti-Tuberculosis Precision Dosing and Comprehensive Clinical Management
The spread of tuberculosis (TB), especially multidrug-resistant TB and extensively drug-resistant TB, has strongly motivat...
Hapln1 promotes dedifferentiation and proliferation of iPSC-derived cardiomyocytes via promoting versican-based GDF11 trapping
Hapln1 promotes dedifferentiation and proliferation of iPSC-derived cardiomyocytes via promoting versican-based GDF11 trapping
Hyaluronan and proteoglycan link protein 1 (Hapln1) supports active cardiomyogenesis in zebrafish hearts, but its regulati...
Distinct molecular targets of ProEGCG from EGCG and superior inhibition of angiogenesis signaling pathways for treatment of endometriosis
Distinct molecular targets of ProEGCG from EGCG and superior inhibition of angiogenesis signaling pathways for treatment of endometriosis
Available online 11 September 2023Author links open overlay panel, , , , , , , , , , , , , , Highlights•Prodrug of epigall...
The role of innate immunity in diabetic nephropathy and their therapeutic consequences
The role of innate immunity in diabetic nephropathy and their therapeutic consequences
Available online 9 September 2023Author links open overlay panel, Highlights•Immunological and inflammatory factors play a...
Targeted protein degradation: A promising approach for cancer treatment
Targeted protein degradation: A promising approach for cancer treatment
Available online 9 September 2023Author links open overlay panel, , , , , Highlights•TPD is a powerful approach that can a...
The role of SLC12A family of cation-chloride cotransporters and drug discovery methodologies
The role of SLC12A family of cation-chloride cotransporters and drug discovery methodologies
The solute carrier family 12 (SLC12) of cation-chloride cotransporters (CCCs) comprises potassium chloride cotransporters ...
Epimedin B exhibits pigmentation by increasing tyrosinase family proteins expression, activity, and stability
Epimedin B exhibits pigmentation by increasing tyrosinase family proteins expression, activity, and stability
Epimedin B (EB) is one of the main flavonoid ingredients present in Epimedium brevicornum Maxim., a traditional herb widel...
Biosensors for Waterborne Virus Detection: Challenges and Strategies
Biosensors for Waterborne Virus Detection: Challenges and Strategies
Available online 31 August 2023Author links open overlay panel, , , , , , Highlights•The manuscript overviews the current ...
A proteomic landscape of pharmacologic perturbations for functional relevance
A proteomic landscape of pharmacologic perturbations for functional relevance
Available online 31 August 2023Author links open overlay panel, , , , , , , , , , Highlights•A dynamic proteomic landscape...
Canonical transient receptor potential channel 1 aggravates myocardial ischemia-and-reperfusion injury by upregulating reactive oxygen species
Canonical transient receptor potential channel 1 aggravates myocardial ischemia-and-reperfusion injury by upregulating reactive oxygen species
The canonical transient receptor potential channel (TRPC) proteins form Ca2+-permeable cation channels that are involved i...
Lipid metabolism analysis in esophageal cancer and associated drug discovery
Lipid metabolism analysis in esophageal cancer and associated drug discovery
Available online 1 September 2023Author links open overlay panel, , , , , Highlights•Explore the molecular characteristics...
Shenqi Fuzheng injection alleviates chemotherapy-induced cachexia by restoring glucocorticoid signaling in hypothalamus
Shenqi Fuzheng injection alleviates chemotherapy-induced cachexia by restoring glucocorticoid signaling in hypothalamus
Available online 24 August 2023Author links open overlay panel, , , , , , , , , , , , , , , , , , Highlights•SQ attenuates...
Application of microfluidic technology based on surface-enhanced Raman scattering in cancer biomarker detection: A review
Application of microfluidic technology based on surface-enhanced Raman scattering in cancer biomarker detection: A review
With the continuous discovery and research of predictive cancer-related biomarkers, liquid biopsy shows great potential in...
Recent advancements in single-cell metabolic analysis for pharmacological research
Recent advancements in single-cell metabolic analysis for pharmacological research
Available online 23 August 2023Author links open overlay panel, , Highlights•Single-cell metabolic analysis for pharmacolo...
Ginsenoside Rc: A potential intervention agent for metabolic syndrome
Ginsenoside Rc: A potential intervention agent for metabolic syndrome
Available online 21 August 2023Author links open overlay panel, , , , , Highlights•Ginsenoside Rc extracted from ginseng h...
Oridonin restores hepatic lipid homeostasis in an LXRα−ATGL/EPT1 axis−dependent manner
Oridonin restores hepatic lipid homeostasis in an LXRα−ATGL/EPT1 axis−dependent manner
Available online 21 August 2023Author links open overlay panel, , , , , , , , , Highlights•Oridonin played an antisteatosi...
Metformin: A promising clinical therapeutical approach for BPH treatment via inhibiting dysregulated steroid hormones-induced prostatic epithelial cells proliferation
Metformin: A promising clinical therapeutical approach for BPH treatment via inhibiting dysregulated steroid hormones-induced prostatic epithelial cells proliferation
The occurrence of benign prostate hyperplasia (BPH) was related to disrupted sex steroid hormones, and metformin (Met) had...
CLDN18.2-targeted molecular imaging and precision therapy of gastrointestinal tumors
CLDN18.2-targeted molecular imaging and precision therapy of gastrointestinal tumors
Available online 18 August 2023Author links open overlay panelYan Chen a b, Zhi Yang a, Xueyun Gao b, Hua Zhu a bShow more...
Integrating UHPLC-MS/MS quantitative analysis and exogenous purine supplementation to elucidate the antidepressant mechanism of Chaigui granules by regulating purine metabolism
Integrating UHPLC-MS/MS quantitative analysis and exogenous purine supplementation to elucidate the antidepressant mechanism of Chaigui granules by regulating purine metabolism
Chaigui granules (CG) are a compound composed of six herbal medicines with significant antidepressant effects. However, th...
Integrated mass spectrometry imaging reveals spatial-metabolic alteration in diabetic cardiomyopathy and the intervention effects of ferulic acid
Integrated mass spectrometry imaging reveals spatial-metabolic alteration in diabetic cardiomyopathy and the intervention effects of ferulic acid
Diabetes cardiomyopathy (DCM) is a metabolic disease and a leading cause of heart failure among people with diabetes. Mass...
Optimization of Nucleic Acid Extraction Methods for Rapid Detection In Pandemic Situations Or Diseases With High Prevalence
Optimization of Nucleic Acid Extraction Methods for Rapid Detection In Pandemic Situations Or Diseases With High Prevalence
Available online 12 August 2023Author links open overlay panel, , , , , , , , Highlights•Heat-based Nucleic Acid Extractio...
27-Hydroxycholesterol/ Liver X Receptor /Apolipoprotein E mediates Zearalenone-induced Intestinal Immunosuppression: A Key Target Potentially Linking Zearalenone and Cancer
27-Hydroxycholesterol/ Liver X Receptor /Apolipoprotein E mediates Zearalenone-induced Intestinal Immunosuppression: A Key Target Potentially Linking Zearalenone and Cancer
Zearalenone (ZEN) is a mycotoxin that extensively contaminates food and feed, posing a significant threat to public health...
Gut-microbiome based thiamine metabolism contributes to the protective effect of one acidic polysaccharide from Selaginella uncinata (Desv.) Spring against inflammatory bowel disease
Gut-microbiome based thiamine metabolism contributes to the protective effect of one acidic polysaccharide from Selaginella uncinata (Desv.) Spring against inflammatory bowel disease
Inflammatory bowel disease (IBD) is a serious disorder, and exploration of active compounds to treat it is necessary. An a...
Hydralazine represses Fpn ubiquitination to rescue injured neurons via competitive binding to UBA52
Hydralazine represses Fpn ubiquitination to rescue injured neurons via competitive binding to UBA52
Available online 11 August 2023Author links open overlay panel, , , , , , , , , , , , , , Highlights•ROS induces neuronal ...
Mapping the metabolic responses to oxaliplatin-based chemotherapy with in vivo spatiotemporal metabolomics
Mapping the metabolic responses to oxaliplatin-based chemotherapy with in vivo spatiotemporal metabolomics
Adjuvant chemotherapy improves the survival outlook for patients undergoing operations for lung metastases caused by color...
Glutaredoxin-1 alleviates acetaminophen-induced liver injury by decreasing its toxic metabolites
Glutaredoxin-1 alleviates acetaminophen-induced liver injury by decreasing its toxic metabolites
Available online 9 August 2023Author links open overlay panel, , , , , , , , , , , , Highlights•Glrx-1 deficiency increase...
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