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Novel insights toward histone lysine methyltransferases in cancer therapy: from epigenetic regulation to selective drugs
Available online 30 November 2022Author links open overlay panelHighlights•We provide an updated overview of the regulator...
Quantitative estimation of enzymatic released specific oligosaccharides from Hericium erinaceus polysaccharides using CE-LIF
Available online 24 November 2022Author links open overlay panelHighlights•Specific oligosaccharides were released from po...
Neurotoxicity mechanism of aconitine in HT22 cells studied by microfluidic chip-mass spectrometry
Available online 23 November 2022Author links open overlay panelHighlights•Aconitine could induce neurotoxicity through ex...
The interaction of polyphyllin I and SQLE protein induces the hepatotoxicity through SREBP2/HMGCR/SQLE/LSS pathway
Available online 19 November 2022Author links open overlay panelHighlights•PPI and PII could induced significant hepatotox...
PKM2-mediated neuronal hyperglycolysis enhances risk of Parkinson's disease in diabetic rats
Available online 21 November 2022Author links open overlay panelHighlights•Increased risk of diabetic Parkinson's disease ...
Drug Adulteration Analysis Based on complexation with CD and Metal Ions Using Ion Mobility Spectrometry
Available online 9 November 2022Highlights•Alp/Thp and Hyt/Thm isomers were analyzed by ion mobility.•Alp/Hyt were disting...
Advances And Challenges In Using Nirmatrelvir And Its Derivatives Against Sars-Cov-2 Infection
Available online 2 November 2022Highlights•Nirmatrelvir and its metabolites inhibit SARS-CoV-2 replication by binding and ...
Evaluation of immunoprotection against coronavirus disease 2019: Novel variants, vaccine inoculation, and complications
Available online 27 October 2022Highlights•Evaluating immunoprotection status may facilitate the design of pharmaceutical ...
Solid-phase microextraction of endogenous metabolites from intact tissue validated using a Biocrates standard reference method kit
Available online 8 October 2022Highlights•A Proof-of-concept study demonstrating solid phase microextraction (SPME) couple...
Tumor-targeting intravenous lipid emulsion of paclitaxel: Characteristics, stability, toxicity, and toxicokinetics
Available online 6 October 2022Highlights•The colloidal stability of PTX Emul was evaluated by static multiple light scatt...
Boosting ferroptosis and microtubule inhibition for antitumor therapy via a carrier-free supermolecule nanoreactor
Available online 7 October 2022Highlights•A supramolecular nanoreactor ([email protected]3+) based on TA, Fe3+, and DOC is...
Metabolomic and elemental profiling of blood serum in bladder cancer
Bladder cancer (BC) is one of the most frequently diagnosed types of urinary cancer. Despite advances in treatment methods...
A highly efficient protein corona-based proteomic analysis strategy for the discovery of pharmacodynamic biomarkers
Available online 7 August 2022Highlights•A protein corona-based proteomic analysis strategy was developed for serum proteo...