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Quantitative characterization of cell physiological state based on dynamical cell mechanics for drug efficacy indication
Cell mechanics is essential to cell development and function and its dynamics evolution reflects the physiological state o...
PKM2-mediated neuronal hyperglycolysis enhances the risk of Parkinson's disease in diabetic rats
Volume 13, Issue 2, February 2023, Pages 187-200Author links open overlay panel, , , , , , , , Highlights•Increased risk o...
Ultrasensitive quantification of trace amines based on N-phosphorylation labeling chip 2D LC-QQQ/MS
Available online 13 February 2023Author links open overlay panel, , , , , , , Highlights•DIPP derivatization-chip 2D LC-QQ...
Solriamfetol impurities: Synthesis, characterization, and analytical method (UPLC-UV) validation
Available online 1 March 2023Author links open overlay panel, , , , , , Highlights•Synthetic routes for eight process-rela...
Recent progress in aptamer-based microfluidics for the detection of circulating tumor cells and extracellular vesicles
Available online 7 March 2023Author links open overlay panel, , , , , Highlights•Liquid biopsy is important for cancer dia...
Single-cell transcriptome analysis reveals the regulatory effects of artesunate on splenic immune cells in polymicrobial sepsis
Sepsis is characterized by a severe and life-threatening host immune response to polymicrobial infection accompanied by or...
Development of a CLDN18.2-targeting Immuno-PET Probe for Non-invasive Imaging in Gastrointestinal Tumors
Claudin18.2 (CLDN18.2) is a tight junction protein that is overexpressed in a variety of solid tumors such as gastrointest...
High-throughput transcriptional profiling of perturbations by Panax ginseng saponins and Panax notoginseng saponins using TCM-seq
Available online 23 February 2023Author links open overlay panel, , , , , , , , , , Highlights•A low-cost workflow of high...
Temporal dynamics of microglia-astrocyte interaction in neuroprotective glial scar formation after intracerebral hemorrhage
Available online 22 February 2023Author links open overlay panel, , , , , , , , , , , , , Highlights•Sustained microglial ...
3D Raman mapping as an analytical tool for investigating the coatings of coated drug particles
The properties of dry-coated paracetamol particles (fast-dissolving model drug) with carnauba wax particles as the coating...
Ultrasensitive quantification of trace amines based on N-phosphorylation labeling chip 2D LC-QQQ/MS
Available online 13 February 2023Author links open overlay panel, , , , , , , Highlights•DIPP derivatization-chip 2D LC-QQ...
Single-cell analysis of cellular heterogeneity and interactions in the ischemia-reperfusion injured mouse intestine
Nine major cell populations among 46,716 cells were identified in mouse intestinal ischemia‒reperfusion (II/R) injury by s...
Rapid authentication of different herbal medicines by heating online extraction electrospray ionization mass spectrometry
The rapid and accurate authentication of traditional Chinese medicines (TCMs) has always been a key scientific and technic...
The interaction between polyphyllin I and SQLE protein induces hepatotoxicity through SREBP-2/HMGCR/SQLE/LSS pathway
Volume 13, Issue 1, January 2023, Pages 39-54Author links open overlay panelHighlights•PPI and PII could induced significa...
Progress and prediction of multicomponent quantification in complex systems with practical LC-UV methods
Available online 5 December 2022Author links open overlay panelHighlights•Reviewing development progress of SSDMC method i...
Microneedle-based interstitial fluid extraction for drug analysis: Advances, challenges, and prospects
Available online 6 January 2023Author links open overlay panelHighlights•The advances in microneedle-assisted interstitial...
Celastrol targeting Nedd4 reduces Nrf2-mediated oxidative stress in astrocytes after ischemic stroke
Available online 7 January 2023Author links open overlay panelHighlights•Celastrol attenuates oxidative stress after CIRI ...
Neutrophil elastase: From mechanisms to therapeutic potential
Available online 7 January 2023Author links open overlay panelHighlights•NE plays a role in several human diseases.•Sivele...
The interaction between polyphyllin I and SQLE protein induces hepatotoxicity through SREBP2/HMGCR/SQLE/LSS pathway
Available online 19 November 2022Author links open overlay panelHighlights•PPI and PII could induced significant hepatotox...
Progress and prediction in multicomponent quantification of complex systems with practical LC-UV methods
Available online 5 December 2022Author links open overlay panelHighlights●Reviewing development progress of SSDMC method i...