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Emerging role of Jumonji domain-containing protein D3 (JMJD3) in inflammatory diseases
Emerging role of Jumonji domain-containing protein D3 (JMJD3) in inflammatory diseases
Available online 16 April 2024, 100978Author links open overlay panel, , , , , , , , , , , Highlights•JMJD3 is an H3K27me2...
Xianling Lianxia formula improves the efficacy of trastuzumab by enhancing NK cell-mediated ADCC in HER2-positive BC
Xianling Lianxia formula improves the efficacy of trastuzumab by enhancing NK cell-mediated ADCC in HER2-positive BC
Trastuzumab has improved survival rates in human epidermal growth factor receptor 2 (HER2)-positive breast cancer (BC), bu...
Fangchinoline induces antiviral response by suppressing STING degradation
Fangchinoline induces antiviral response by suppressing STING degradation
The stimulator of interferon genes (STING), an integral adaptor protein in the DNA-sensing pathway, plays a pivotal role i...
Pharmacometabolomics and Mass Spectrometry Imaging Approach to Reveal the Neurochemical Mechanisms of Polygala tenuifolia
Pharmacometabolomics and Mass Spectrometry Imaging Approach to Reveal the Neurochemical Mechanisms of Polygala tenuifolia
Polygala tenuifolia, commonly known as Yuanzhi (YZ) in Chinese, has been shown to possess anti-insomnia properties. Howeve...
Advancing drug safety and mitigating health concerns: High-resolution mass spectrometry in the levothyroxine case study
Advancing drug safety and mitigating health concerns: High-resolution mass spectrometry in the levothyroxine case study
Levothyroxine is a drug with a narrow therapeutic index. Changing the drug formulation composition or switching between ph...
Baicalein: a potential GLP-1R agonist improves cognitive disorder of diabetes through mitophagy enhancement
Baicalein: a potential GLP-1R agonist improves cognitive disorder of diabetes through mitophagy enhancement
There is increasing evidence that the activation of glucagon-like peptide-1 receptor (GLP-1R) can be used as a therapeutic...
CA IX-targeted Ag2S Quantum Dots Bioprobe for NIR-II Imaging-guided Hypoxia tumor Chemo-Photothermal Therapy
CA IX-targeted Ag2S Quantum Dots Bioprobe for NIR-II Imaging-guided Hypoxia tumor Chemo-Photothermal Therapy
Hypoxia is the common characteristic of almost all solid tumors, which prevents therapeutic drugs from reaching the tumors...
Establishment of microneurovascular units in alginate hydrogel microspheres to reveal the anti-hypoxic effect of salidroside
Establishment of microneurovascular units in alginate hydrogel microspheres to reveal the anti-hypoxic effect of salidroside
Available online 20 March 2024, 100967Author links open overlay panel, , , , , , , Editor highlights•Microfluidic co-cultu...
Mapping conformational changes on bispecific antigen-binding biotherapeutic by covalent labeling and mass spectrometry
Mapping conformational changes on bispecific antigen-binding biotherapeutic by covalent labeling and mass spectrometry
Biotherapeutic’s higher order structure (HOS) is a critical determinant of its functional properties and conformational re...
Progress and application of intelligent nanomedicine in urinary system tumors
Progress and application of intelligent nanomedicine in urinary system tumors
Urinary system tumors include malignancies of the bladder, kidney, and prostate, and present considerable challenges in di...
Mechanisms and therapeutic targets of ferroptosis: Implications for nanomedicine design
Mechanisms and therapeutic targets of ferroptosis: Implications for nanomedicine design
Available online 8 March 2024Author links open overlay panel, , , , , Highlights•Ferroptosis is different from the well-kn...
Signal interference between drugs and metabolites in LC-ESI-MS quantitative analysis and its evaluation strategy
Signal interference between drugs and metabolites in LC-ESI-MS quantitative analysis and its evaluation strategy
Liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI-MS) is a widely utilized technique for in v...
IR-EcoSpectra: Exploring sustainable ex situ and in situ FTIR applications for green chemical and pharmaceutical analysis
IR-EcoSpectra: Exploring sustainable ex situ and in situ FTIR applications for green chemical and pharmaceutical analysis
In various industries, particularly the chemical and pharmaceutical fields, Fourier transform infrared spectroscopy (FTIR)...
Non-coding RNAs as therapeutic targets in cancer and its clinical application
Non-coding RNAs as therapeutic targets in cancer and its clinical application
Available online 8 February 2024Author links open overlay panel, , , , , , , , , , , Highlights•The classification, synthe...
Automated and integrated ultrahigh throughput industrial strain screening enabled by acoustic-droplet-ejection mass spectrometry
Automated and integrated ultrahigh throughput industrial strain screening enabled by acoustic-droplet-ejection mass spectrometry
Available online 10 February 2024Author links open overlay panel, , , , , , , , , , Highlights•UTPA, with ADE-OPI-MS and s...