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Quantitative characterization of cell physiological state based on dynamical cell mechanics for drug efficacy indication
Cell mechanics is essential to cell development and function and its dynamics evolution reflects the physiological state o...
PKM2-mediated neuronal hyperglycolysis enhances the risk of Parkinson's disease in diabetic rats
Volume 13, Issue 2, February 2023, Pages 187-200Author links open overlay panel, , , , , , , , Highlights•Increased risk o...
Ultrasensitive quantification of trace amines based on N-phosphorylation labeling chip 2D LC-QQQ/MS
Available online 13 February 2023Author links open overlay panel, , , , , , , Highlights•DIPP derivatization-chip 2D LC-QQ...
Discovering metabolic vulnerability using spatially resolved metabolomics for antitumor small molecule-drug conjugates development as a precise cancer therapy strategy
Against tumor-dependent metabolic vulnerability is an attractive strategy for tumor-targeted therapy. However, metabolic i...
Solriamfetol impurities: Synthesis, characterization, and analytical method (UPLC-UV) validation
Available online 1 March 2023Author links open overlay panel, , , , , , Highlights•Synthetic routes for eight process-rela...
Recent progress in aptamer-based microfluidics for the detection of circulating tumor cells and extracellular vesicles
Available online 7 March 2023Author links open overlay panel, , , , , Highlights•Liquid biopsy is important for cancer dia...
Single-cell transcriptome analysis reveals the regulatory effects of artesunate on splenic immune cells in polymicrobial sepsis
Sepsis is characterized by a severe and life-threatening host immune response to polymicrobial infection accompanied by or...
Development of a CLDN18.2-targeting Immuno-PET Probe for Non-invasive Imaging in Gastrointestinal Tumors
Claudin18.2 (CLDN18.2) is a tight junction protein that is overexpressed in a variety of solid tumors such as gastrointest...
High-throughput transcriptional profiling of perturbations by Panax ginseng saponins and Panax notoginseng saponins using TCM-seq
Available online 23 February 2023Author links open overlay panel, , , , , , , , , , Highlights•A low-cost workflow of high...
Temporal dynamics of microglia-astrocyte interaction in neuroprotective glial scar formation after intracerebral hemorrhage
Available online 22 February 2023Author links open overlay panel, , , , , , , , , , , , , Highlights•Sustained microglial ...
Breath-by-breath measurement of exhaled ammonia by acetone-modifier positive photoionization ion mobility spectrometry via online dilution and purging sampling
Exhaled ammonia (NH3) is an essential noninvasive biomarker for disease diagnosis. In this study, an acetone-modifier posi...
3D Raman mapping as an analytical tool for investigating the coatings of coated drug particles
The properties of dry-coated paracetamol particles (fast-dissolving model drug) with carnauba wax particles as the coating...
Personal Glucose Meters Coupled with Signal Amplification Technologies for Quantitative Detection of Non-Glucose Targets: Recent Progress and Challenges in Food Safety Hazards Analysis
Available online 16 February 2023Author links open overlay panel, , , , , , , , , Highlights•PGM is an effective tool for ...
Ultrasensitive quantification of trace amines based on N-phosphorylation labeling chip 2D LC-QQQ/MS
Available online 13 February 2023Author links open overlay panel, , , , , , , Highlights•DIPP derivatization-chip 2D LC-QQ...
Overcoming chemoresistance in non-angiogenic colorectal cancer by metformin via inhibiting endothelial apoptosis and vascular immaturity
Available online 9 February 2023Author links open overlay panel, , , , , , , , , , , , Highlights•CRCs with a non-angiogen...
Single-cell analysis of cellular heterogeneity and interactions in the ischemia-reperfusion injured mouse intestine
Nine major cell populations among 46,716 cells were identified in mouse intestinal ischemia‒reperfusion (II/R) injury by s...
Rapid authentication of different herbal medicines by heating online extraction electrospray ionization mass spectrometry
The rapid and accurate authentication of traditional Chinese medicines (TCMs) has always been a key scientific and technic...
Recent applications and chiral separation developments based on stationary phases in open tubular capillary electrochromatography (2019–2022)
Capillary electrochromatography (CEC) plays a significant role in chiral separation via the double separation principle, p...
The interaction between polyphyllin I and SQLE protein induces hepatotoxicity through SREBP-2/HMGCR/SQLE/LSS pathway
Volume 13, Issue 1, January 2023, Pages 39-54Author links open overlay panelHighlights•PPI and PII could induced significa...
Progress and prediction of multicomponent quantification in complex systems with practical LC-UV methods
Available online 5 December 2022Author links open overlay panelHighlights•Reviewing development progress of SSDMC method i...
Fragmentation stability and retention time-shift obtained by LC-MS/MS to distinguish sialylated N-glycan linkage isomers in therapeutic glycoproteins
Sialylated N-glycan isomers with α2-3 or α2-6 linkage(s) have distinctive roles in glycoproteins, but are difficult to dis...
Microneedle-based interstitial fluid extraction for drug analysis: Advances, challenges, and prospects
Available online 6 January 2023Author links open overlay panelHighlights•The advances in microneedle-assisted interstitial...
Celastrol targeting Nedd4 reduces Nrf2-mediated oxidative stress in astrocytes after ischemic stroke
Available online 7 January 2023Author links open overlay panelHighlights•Celastrol attenuates oxidative stress after CIRI ...
Neutrophil elastase: From mechanisms to therapeutic potential
Available online 7 January 2023Author links open overlay panelHighlights•NE plays a role in several human diseases.•Sivele...
Multidisciplinary strategies to enhance therapeutic effects of flavonoids from Epimedii Folium: Integration of herbal medicine, enzyme engineering, and nanotechnology
Available online 30 December 2022Author links open overlay panelHighlights•Icaritin soft capsules have been approved for t...
Identification of potential anti-pneumonia pharmacological components of Glycyrrhizae Radix et Rhizoma after the treatment with Gan An He Ji oral liquid
Volume 12, Issue 6, December 2022, Pages 839-851Author links open overlay panelHighlights•The screening of the pharmacolog...
Discovery of pulmonary fibrosis inhibitor targeting TGF-β RI in Polygonum cuspidatum by high resolution mass spectrometry with in silico strategy
Volume 12, Issue 6, December 2022, Pages 860-868Author links open overlay panelHighlights•The LC-HR MS method allows the i...
Corrigendum to “The potential of miRNA-based therapeutics in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection: A review” [J. Pharma. Anal. 11 (2021) 265–271]
Volume 12, Issue 6, December 2022, Page 937Author links open overlay panelLeonnyDwi RizkitaIndwianiAstutiPersonEnvelopeSho...
The interaction between polyphyllin I and SQLE protein induces hepatotoxicity through SREBP2/HMGCR/SQLE/LSS pathway
Available online 19 November 2022Author links open overlay panelHighlights•PPI and PII could induced significant hepatotox...
Progress and prediction in multicomponent quantification of complex systems with practical LC-UV methods
Available online 5 December 2022Author links open overlay panelHighlights●Reviewing development progress of SSDMC method i...
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