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Baicalein: a potential GLP-1R agonist improves cognitive disorder of diabetes through mitophagy enhancement
Baicalein: a potential GLP-1R agonist improves cognitive disorder of diabetes through mitophagy enhancement
There is increasing evidence that the activation of glucagon-like peptide-1 receptor (GLP-1R) can be used as a therapeutic...
CA IX-targeted Ag2S Quantum Dots Bioprobe for NIR-II Imaging-guided Hypoxia tumor Chemo-Photothermal Therapy
CA IX-targeted Ag2S Quantum Dots Bioprobe for NIR-II Imaging-guided Hypoxia tumor Chemo-Photothermal Therapy
Hypoxia is the common characteristic of almost all solid tumors, which prevents therapeutic drugs from reaching the tumors...
Establishment of microneurovascular units in alginate hydrogel microspheres to reveal the anti-hypoxic effect of salidroside
Establishment of microneurovascular units in alginate hydrogel microspheres to reveal the anti-hypoxic effect of salidroside
Available online 20 March 2024, 100967Author links open overlay panel, , , , , , , Editor highlights•Microfluidic co-cultu...
Mapping conformational changes on bispecific antigen-binding biotherapeutic by covalent labeling and mass spectrometry
Mapping conformational changes on bispecific antigen-binding biotherapeutic by covalent labeling and mass spectrometry
Biotherapeutic’s higher order structure (HOS) is a critical determinant of its functional properties and conformational re...
Progress and application of intelligent nanomedicine in urinary system tumors
Progress and application of intelligent nanomedicine in urinary system tumors
Urinary system tumors include malignancies of the bladder, kidney, and prostate, and present considerable challenges in di...
Mechanisms and therapeutic targets of ferroptosis: Implications for nanomedicine design
Mechanisms and therapeutic targets of ferroptosis: Implications for nanomedicine design
Available online 8 March 2024Author links open overlay panel, , , , , Highlights•Ferroptosis is different from the well-kn...
Signal interference between drugs and metabolites in LC-ESI-MS quantitative analysis and its evaluation strategy
Signal interference between drugs and metabolites in LC-ESI-MS quantitative analysis and its evaluation strategy
Liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI-MS) is a widely utilized technique for in v...
IR-EcoSpectra: Exploring sustainable ex situ and in situ FTIR applications for green chemical and pharmaceutical analysis
IR-EcoSpectra: Exploring sustainable ex situ and in situ FTIR applications for green chemical and pharmaceutical analysis
In various industries, particularly the chemical and pharmaceutical fields, Fourier transform infrared spectroscopy (FTIR)...
Non-coding RNAs as therapeutic targets in cancer and its clinical application
Non-coding RNAs as therapeutic targets in cancer and its clinical application
Available online 8 February 2024Author links open overlay panel, , , , , , , , , , , Highlights•The classification, synthe...
Automated and integrated ultrahigh throughput industrial strain screening enabled by acoustic-droplet-ejection mass spectrometry
Automated and integrated ultrahigh throughput industrial strain screening enabled by acoustic-droplet-ejection mass spectrometry
Available online 10 February 2024Author links open overlay panel, , , , , , , , , , Highlights•UTPA, with ADE-OPI-MS and s...
Global hotspots and future directions for drugs to improve the skin flap survival: A bibliometric and visualized review
Global hotspots and future directions for drugs to improve the skin flap survival: A bibliometric and visualized review
Available online 6 February 2024Author links open overlay panel, , , , , , , Highlights•The bibliometric method was used t...
Natural compounds improve diabetic nephropathy by regulating the TLR4 signaling pathway
Natural compounds improve diabetic nephropathy by regulating the TLR4 signaling pathway
Diabetic nephropathy (DN), a severe complication of diabetes, is widely recognized as a primary contributor to end-stage r...
Dual mass spectrometry imaging and spatial metabolomics to investigate the metabolism and nephrotoxicity of nitidine chloride
Dual mass spectrometry imaging and spatial metabolomics to investigate the metabolism and nephrotoxicity of nitidine chloride
Evaluating toxicity and decoding the underlying mechanisms of active compounds are crucial for drug development. In this s...
Paeoniflorin ameliorates chronic colitis via the DR3 signaling pathway in group 3 innate lymphoid cells
Paeoniflorin ameliorates chronic colitis via the DR3 signaling pathway in group 3 innate lymphoid cells
Inhibiting the death receptor 3 (DR3) signaling pathway in group 3 innate lymphoid cells (ILC3s) presents a promising appr...
PEG-PLGA nanoparticles deposited in Pseudomonas aeruginosa and Burkolderia cenocepacia
PEG-PLGA nanoparticles deposited in Pseudomonas aeruginosa and Burkolderia cenocepacia
Available online 26 January 2024Author links open overlay panel, , , , , , Highlights•Tracking deposition of organic nanop...