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Machine learning-driven identification of critical gene programs and key transcription factors in migraine
Machine learning-driven identification of critical gene programs and key transcription factors in migraine
Migraine is a complex neurological disorder characterized by recurrent episodes of severe headaches. Although genetic fact...
Medication underuse in real-life practice: the impact of galcanezumab towards achieving very low frequency episodic migraine in a southeast Asian middle-income nation
Medication underuse in real-life practice: the impact of galcanezumab towards achieving very low frequency episodic migraine in a southeast Asian middle-income nation
Migraine progression, particularly from episodic to chronic migraine (CM), increases disease burden and healthcare costs. ...
Differentially localizing isoforms of the migraine component calcitonin gene-related peptide (CGRP), in the mouse trigeminal ganglion: βCGRP is translated but, unlike αCGRP, not sorted into axons
Differentially localizing isoforms of the migraine component calcitonin gene-related peptide (CGRP), in the mouse trigeminal ganglion: βCGRP is translated but, unlike αCGRP, not sorted into axons
The neuropeptide calcitonin gene-related peptide (CGRP) has been established to be a key signaling molecule in migraine, b...
MRI-based analysis of the microstructure of the thalamus and hypothalamus and functional connectivity between cortical networks in episodic cluster headache
MRI-based analysis of the microstructure of the thalamus and hypothalamus and functional connectivity between cortical networks in episodic cluster headache
Neuroimaging studies have shown that hypothalamic/thalamic nuclei and other distant brain regions belonging to complex cer...
Aura phenomenon: a proposal for an etiology-based clinical classification
Aura phenomenon: a proposal for an etiology-based clinical classification
The term “aura” refers to a well-defined pattern of usually positive, progressive, and reversible neurological...
Consistency between headache diagnoses and ICHD-3 criteria across different levels of care
Consistency between headache diagnoses and ICHD-3 criteria across different levels of care
Diagnosing headache disorders poses significant challenges, particularly in primary and secondary levels of care (PSLC), p...
A robust multimodal brain MRI-based diagnostic model for migraine: validation across different migraine phases and longitudinal follow-up data
A robust multimodal brain MRI-based diagnostic model for migraine: validation across different migraine phases and longitudinal follow-up data
Inter-individual variability in symptoms and the dynamic nature of brain pathophysiology present significant challenges in...
The burden of headache disorders among medical students in Vietnam: estimates from a cross-sectional study with a health-care needs assessment
The burden of headache disorders among medical students in Vietnam: estimates from a cross-sectional study with a health-care needs assessment
In our previous study, we demonstrated that headaches are highly prevalent among medical students in Vietnam. In the prese...
Serial systemic immune inflammation indices: markers of acute migraine events or indicators of persistent inflammatory status?
Serial systemic immune inflammation indices: markers of acute migraine events or indicators of persistent inflammatory status?
Migraine is the most common complex neurological disorder, affecting over a billion people worldwide. Neurogenic inflammat...
Effectiveness and tolerability of rimegepant in the acute treatment of migraine: a real-world, prospective, multicentric study (GAINER study)
Effectiveness and tolerability of rimegepant in the acute treatment of migraine: a real-world, prospective, multicentric study (GAINER study)
Rimegepant, a novel oral calcitonin gene-related peptide receptor antagonist, has been recently approved for the acute mig...
Influence of next-generation artificial intelligence on headache research, diagnosis and treatment: the junior editorial board members’ vision – part 2
Influence of next-generation artificial intelligence on headache research, diagnosis and treatment: the junior editorial board members’ vision – part 2
Part 2 explores the transformative potential of artificial intelligence (AI) in addressing the complexities of headache di...
Reduction of pain and functional disability over time in patients treated with zavegepant: a post-hoc analysis of the BHV3500-301 phase 3 randomized controlled trial
Reduction of pain and functional disability over time in patients treated with zavegepant: a post-hoc analysis of the BHV3500-301 phase 3 randomized controlled trial
Migraine is a disabling disorder that impacts 40 million people in the US. Zavegepant is the first calcitonin gene-related...
Migraine in men
Migraine in men
Migraine is a common primary headache disorder, less frequently affecting men than women, and often regarded as predominan...
The burden of headache disorders in the adult population of Morocco: estimates, and a health-care needs assessment, from a cross-sectional population-based door-to-door survey
The burden of headache disorders in the adult population of Morocco: estimates, and a health-care needs assessment, from a cross-sectional population-based door-to-door survey
We have previously shown headache disorders to be prevalent in in the adult general population of Morocco, especially migr...
Epidemiological, clinical characterization and treatment patterns of migraine patients in a Colombian cohort from 2018 to 2022
Epidemiological, clinical characterization and treatment patterns of migraine patients in a Colombian cohort from 2018 to 2022
To describe the epidemiology and clinical characteristics of migraine and the status of treatment in Colombia. Additionall...
Migraine in the multiple sclerosis prodrome: a prospective nationwide cohort study in pregnant women
Migraine in the multiple sclerosis prodrome: a prospective nationwide cohort study in pregnant women
People with multiple sclerosis (MS) have an increased risk of migraine. However, little is known about migraine and other ...
Cerebral blood flow and arterial responses in migraine: history and future perspectives
Cerebral blood flow and arterial responses in migraine: history and future perspectives
It is largely accepted that migraine with aura (MA) is caused by cortical spreading depression (CSD) and that migraine wit...
Interictal burden in migraine patients at the outset of CGRP monoclonal antibody prevention
Interictal burden in migraine patients at the outset of CGRP monoclonal antibody prevention
The total burden of migraine includes not only the episodes with headache pain but extends throughout the interictal perio...
Pain profiling in migraine: a systematic review of Quantitative Sensory Testing (QST), Conditioned Pain Modulation (CPM), and Corneal Confocal Microscopy (CCM)
Pain profiling in migraine: a systematic review of Quantitative Sensory Testing (QST), Conditioned Pain Modulation (CPM), and Corneal Confocal Microscopy (CCM)
The aim of this systematic review is to identify pain profiling parameters that are reliably different between patients wi...
Migraine and cognitive dysfunction: a narrative review
Migraine and cognitive dysfunction: a narrative review
The association between migraine and cognitive function has been studied during the last decade, however, this relationshi...
Prevalence and risk factors of headache in Chinese with stroke: a cross-sectional study based on CHARLS
Prevalence and risk factors of headache in Chinese with stroke: a cross-sectional study based on CHARLS
Stroke ranks as the second leading cause of death worldwide. Meanwhile, headaches are considered the second leading cause ...
Male-female comparison of vasomotor effects of circulating hormones in human intracranial arteries
Male-female comparison of vasomotor effects of circulating hormones in human intracranial arteries
The purpose of this study was to examine whether there are sex differences in vasomotor responses and receptor localizatio...
Machine learning classification meets migraine: recommendations for study evaluation
Machine learning classification meets migraine: recommendations for study evaluation
The integration of machine learning (ML) classification techniques into migraine research has offered new insights into th...
Combining treatments for migraine prophylaxis: the state-of-the-art
Combining treatments for migraine prophylaxis: the state-of-the-art
Combination treatments for migraine prophylaxis present a promising approach to addressing the diverse and complex mechani...
Elevated plasma CXCL12 leads to pain chronicity via positive feedback upregulation of CXCL12/CXCR4 axis in pain synapses
Elevated plasma CXCL12 leads to pain chronicity via positive feedback upregulation of CXCL12/CXCR4 axis in pain synapses
Chronic pain poses a clinical challenge due to its associated costly disability and treatment needs. Determining how pain ...
Efficacy and safety profile of Onabotulinum toxin-A injection at sphenopalatine ganglion in trigeminal neuralgia: a prospective observational study
Efficacy and safety profile of Onabotulinum toxin-A injection at sphenopalatine ganglion in trigeminal neuralgia: a prospective observational study
The sphenopalatine ganglion (SPG) plays a role in orofacial pain and headaches and is a target for pain modulation. Onabot...
Resistant and refractory migraine – two different entities with different comorbidities? Results from the REFINE study
Resistant and refractory migraine – two different entities with different comorbidities? Results from the REFINE study
Resistant and refractory migraine are commonly encountered in specialized headache centers. Several comorbidities, mostly ...
Cluster headache and galcanezumab: the first real-world Brazilian study and an expert consensus on its use among other treatments
Cluster headache and galcanezumab: the first real-world Brazilian study and an expert consensus on its use among other treatments
To present the first Brazilian real-world results with galcanezumab and provide a consensus expert opinion on the prophyla...
Intrathecal lactate dehydrogenase A inhibitors FX11 and oxamate alleviate chronic constriction injury-induced nociceptive sensitization through neuroinflammation and angiogenesis
Intrathecal lactate dehydrogenase A inhibitors FX11 and oxamate alleviate chronic constriction injury-induced nociceptive sensitization through neuroinflammation and angiogenesis
Neuropathic pain involves neuroinflammation and upregulation of glycolysis in the central nervous system. Unfortunately, f...
Potential hypothalamic mechanisms in trigeminal neuropathic pain: a comparative analysis with migraine and cluster headache
Potential hypothalamic mechanisms in trigeminal neuropathic pain: a comparative analysis with migraine and cluster headache
Trigeminal neuropathic pain (TNP), migraine, and cluster headache (CH) profoundly impact the quality of life and present s...
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