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Cerebral blood flow and arterial responses in migraine: history and future perspectives
Cerebral blood flow and arterial responses in migraine: history and future perspectives
It is largely accepted that migraine with aura (MA) is caused by cortical spreading depression (CSD) and that migraine wit...
Interictal burden in migraine patients at the outset of CGRP monoclonal antibody prevention
Interictal burden in migraine patients at the outset of CGRP monoclonal antibody prevention
The total burden of migraine includes not only the episodes with headache pain but extends throughout the interictal perio...
Pain profiling in migraine: a systematic review of Quantitative Sensory Testing (QST), Conditioned Pain Modulation (CPM), and Corneal Confocal Microscopy (CCM)
Pain profiling in migraine: a systematic review of Quantitative Sensory Testing (QST), Conditioned Pain Modulation (CPM), and Corneal Confocal Microscopy (CCM)
The aim of this systematic review is to identify pain profiling parameters that are reliably different between patients wi...
Migraine and cognitive dysfunction: a narrative review
Migraine and cognitive dysfunction: a narrative review
The association between migraine and cognitive function has been studied during the last decade, however, this relationshi...
Prevalence and risk factors of headache in Chinese with stroke: a cross-sectional study based on CHARLS
Prevalence and risk factors of headache in Chinese with stroke: a cross-sectional study based on CHARLS
Stroke ranks as the second leading cause of death worldwide. Meanwhile, headaches are considered the second leading cause ...
Male-female comparison of vasomotor effects of circulating hormones in human intracranial arteries
Male-female comparison of vasomotor effects of circulating hormones in human intracranial arteries
The purpose of this study was to examine whether there are sex differences in vasomotor responses and receptor localizatio...
Machine learning classification meets migraine: recommendations for study evaluation
Machine learning classification meets migraine: recommendations for study evaluation
The integration of machine learning (ML) classification techniques into migraine research has offered new insights into th...
Combining treatments for migraine prophylaxis: the state-of-the-art
Combining treatments for migraine prophylaxis: the state-of-the-art
Combination treatments for migraine prophylaxis present a promising approach to addressing the diverse and complex mechani...
Elevated plasma CXCL12 leads to pain chronicity via positive feedback upregulation of CXCL12/CXCR4 axis in pain synapses
Elevated plasma CXCL12 leads to pain chronicity via positive feedback upregulation of CXCL12/CXCR4 axis in pain synapses
Chronic pain poses a clinical challenge due to its associated costly disability and treatment needs. Determining how pain ...
Efficacy and safety profile of Onabotulinum toxin-A injection at sphenopalatine ganglion in trigeminal neuralgia: a prospective observational study
Efficacy and safety profile of Onabotulinum toxin-A injection at sphenopalatine ganglion in trigeminal neuralgia: a prospective observational study
The sphenopalatine ganglion (SPG) plays a role in orofacial pain and headaches and is a target for pain modulation. Onabot...
Resistant and refractory migraine – two different entities with different comorbidities? Results from the REFINE study
Resistant and refractory migraine – two different entities with different comorbidities? Results from the REFINE study
Resistant and refractory migraine are commonly encountered in specialized headache centers. Several comorbidities, mostly ...
Cluster headache and galcanezumab: the first real-world Brazilian study and an expert consensus on its use among other treatments
Cluster headache and galcanezumab: the first real-world Brazilian study and an expert consensus on its use among other treatments
To present the first Brazilian real-world results with galcanezumab and provide a consensus expert opinion on the prophyla...
Intrathecal lactate dehydrogenase A inhibitors FX11 and oxamate alleviate chronic constriction injury-induced nociceptive sensitization through neuroinflammation and angiogenesis
Intrathecal lactate dehydrogenase A inhibitors FX11 and oxamate alleviate chronic constriction injury-induced nociceptive sensitization through neuroinflammation and angiogenesis
Neuropathic pain involves neuroinflammation and upregulation of glycolysis in the central nervous system. Unfortunately, f...
Potential hypothalamic mechanisms in trigeminal neuropathic pain: a comparative analysis with migraine and cluster headache
Potential hypothalamic mechanisms in trigeminal neuropathic pain: a comparative analysis with migraine and cluster headache
Trigeminal neuropathic pain (TNP), migraine, and cluster headache (CH) profoundly impact the quality of life and present s...
Impact of migraine on changes in cardiovascular health profile among Hong Kong Chinese women: insights from the MECH-HK cohort study
Impact of migraine on changes in cardiovascular health profile among Hong Kong Chinese women: insights from the MECH-HK cohort study
Previous research has shown an association between migraine and cardiovascular diseases (CVDs). However, limited studies h...
The burden of headache disorders among adults in Peru: national estimates and a health-care needs assessment from a population-based door-to-door survey
The burden of headache disorders among adults in Peru: national estimates and a health-care needs assessment from a population-based door-to-door survey
We have previously found that almost two thirds (64.6%) of adults in Peru have an active headache disorder. Here, using da...
Real-world study of adverse events associated with triptan use in migraine treatment based on the U.S. Food and Drug Administration (FDA) adverse event reporting system (FAERS) database
Real-world study of adverse events associated with triptan use in migraine treatment based on the U.S. Food and Drug Administration (FDA) adverse event reporting system (FAERS) database
Triptans selectively agoniste 5-Hydroxytryptamine(5-HT) receptors and are widely used in the treatment of migraine. Nevert...
Disrupted topologic efficiency of white matter structural connectome in migraine: a graph-based connectomics study
Disrupted topologic efficiency of white matter structural connectome in migraine: a graph-based connectomics study
To delineate the structural connectome alterations in patients with chronic migraine (CM), episodic migraine (EM), and hea...
Distinct expression profile reveals glia involvement in the trigeminal system attributing to post-traumatic headache
Distinct expression profile reveals glia involvement in the trigeminal system attributing to post-traumatic headache
Post-traumatic headache (PTH) is a common comorbid symptom affecting at least one-third of patients with mild traumatic br...
Plasma pQTL and brain eQTL integration identifies PNKP as a therapeutic target and reveals mechanistic insights into migraine pathophysiology
Plasma pQTL and brain eQTL integration identifies PNKP as a therapeutic target and reveals mechanistic insights into migraine pathophysiology
Migraine is a prevalent neurological disorder affecting 14.1% of the global population. Despite advances in genetic resear...
Formoterol dynamically alters endocannabinoid tone in the periaqueductal gray inducing headache
Formoterol dynamically alters endocannabinoid tone in the periaqueductal gray inducing headache
Headache is a pain disorder present in populations world-wide with a higher incidence in females. Specifically, the incide...
The PopHEAD study: a population-based, cross-sectional study on headache burden in Norway: methods and validation of questionnaire-based diagnoses
The PopHEAD study: a population-based, cross-sectional study on headache burden in Norway: methods and validation of questionnaire-based diagnoses
There is a lack of up-to-date information on the prevalence and burden of headache in Norway. Here we describe the methods...
Serum microRNA qPCR profiling and validation indicate upregulation of circulating miR-145-5p and miR-26a-5p in migraineurs
Serum microRNA qPCR profiling and validation indicate upregulation of circulating miR-145-5p and miR-26a-5p in migraineurs
In recent years, miRNAs found in biological fluids have gained interest as biomarkers of numerous conditions, including mi...
Regulatory T cells require peripheral CCL2-CCR2 signaling to facilitate the resolution of medication overuse headache-related behavioral sensitization
Regulatory T cells require peripheral CCL2-CCR2 signaling to facilitate the resolution of medication overuse headache-related behavioral sensitization
Medication overuse headache (MOH) is the most common secondary headache disorder, resulting from chronic and excessive use...
Attentional network deficits in patients with migraine: behavioral and electrophysiological evidence
Attentional network deficits in patients with migraine: behavioral and electrophysiological evidence
Patients with migraine often experience not only headache pain but also cognitive dysfunction, particularly in attention, ...
Immune cells mediate the effects of gut microbiota on neuropathic pain: a Mendelian randomization study
Immune cells mediate the effects of gut microbiota on neuropathic pain: a Mendelian randomization study
The gut microbiota may be involved in neuropathic pain. However, the causal association between gut microbiota and neuropa...
Efficacy of lasmiditan, rimegepant and ubrogepant for acute treatment of migraine in triptan insufficient responders: systematic review and network meta-analysis
Efficacy of lasmiditan, rimegepant and ubrogepant for acute treatment of migraine in triptan insufficient responders: systematic review and network meta-analysis
Novel abortive treatments for migraine, ditans and gepants, have promising implications in triptan-insufficient responders...
Microbiota alterations are related to migraine food triggers and inflammatory markers in chronic migraine patients with medication overuse headache
Microbiota alterations are related to migraine food triggers and inflammatory markers in chronic migraine patients with medication overuse headache
Chronic migraine (CM) patients with medication overuse headache (MOH) were recently shown to be associated with leaky gut ...
Sex differences in expression of CGRP family of receptors and ligands in the rat trigeminal system
Sex differences in expression of CGRP family of receptors and ligands in the rat trigeminal system
Calcitonin gene-related peptide (CGRP) is part of the calcitonin peptide family, which includes calcitonin (CT), amylin (A...
Reduction of neck pain severity in patients with medication-overuse headache
Reduction of neck pain severity in patients with medication-overuse headache
Neck pain and primary headache disorders are highly prevalent in populations and clinical cohorts. Medication-overuse head...
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