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Efficacy and safety of intranasal agents for the acute treatment of migraine: a systematic review and network meta-analysis
Efficacy and safety of intranasal agents for the acute treatment of migraine: a systematic review and network meta-analysis
Intranasal agents may be ideal for the treatment of migraine patients. Many new acute intranasal-specific therapies have b...
Quality of life in children suffering from headaches: a systematic literature review
Quality of life in children suffering from headaches: a systematic literature review
Headaches are the most common complaints among pediatric populations. Determining the cause and appropriate treatment for ...
Global, regional, and national epidemiology of migraine and tension-type headache in youths and young adults aged 15–39 years from 1990 to 2019: findings from the global burden of disease study 2019
Global, regional, and national epidemiology of migraine and tension-type headache in youths and young adults aged 15–39 years from 1990 to 2019: findings from the global burden of disease study 2019
In recent years, headache disorders have garnered significant attention as a pressing global health issue. This concern is...
Serum tau protein elevation in migraine: a cross-sectional case–control study
Serum tau protein elevation in migraine: a cross-sectional case–control study
Migraine is a disorder associated with neuropeptide release, pain and inflammation. Tau protein has recently been linked t...
European Headache Federation (EHF) critical re-appraisal and meta-analysis of oral drugs in migraine prevention—part 2: flunarizine
European Headache Federation (EHF) critical re-appraisal and meta-analysis of oral drugs in migraine prevention—part 2: flunarizine
Novel disease-specific and mechanism-based treatments sharing good evidence of efficacy for migraine have been recently ma...
Mode and site of action of therapies targeting CGRP signaling
Mode and site of action of therapies targeting CGRP signaling
Targeting CGRP has proved to be efficacious, tolerable, and safe to treat migraine; however, many patients with migraine d...
Investigating the relationship between sleep and migraine in a global sample: a Bayesian cross-sectional approach
Investigating the relationship between sleep and migraine in a global sample: a Bayesian cross-sectional approach
There is a bidirectional link between sleep and migraine, however causality is difficult to determine. This study aimed to...
Calcitonin gene-related peptide causes migraine aura
Calcitonin gene-related peptide causes migraine aura
Although the involvement of calcitonin gene-related peptide (CGRP) in migraines is well-established, its specific role in ...
Proteomics profiling reveals mitochondrial damage in the thalamus in a mouse model of chronic migraine
Proteomics profiling reveals mitochondrial damage in the thalamus in a mouse model of chronic migraine
Migraine, a complex brain disorder, is regarded as a possible clinical manifestation of brain energy dysfunction. The trig...
Current treatment options for cluster headache: limitations and the unmet need for better and specific treatments—a consensus article
Current treatment options for cluster headache: limitations and the unmet need for better and specific treatments—a consensus article
Treatment for cluster headache is currently based on a trial-and-error approach. The available preventive treatment is uns...
Who cares about migraine? Pathways and hurdles in the European region - access to care III
Who cares about migraine? Pathways and hurdles in the European region - access to care III
Migraine is a highly prevalent primary headache disorder and a leading cause of disability. Difficulties in access to care...
Status of diagnosis and preventative treatment for primary headache disorders: real-world data of unmet needs in China
Status of diagnosis and preventative treatment for primary headache disorders: real-world data of unmet needs in China
Headache disorders are widely prevalent and pose a considerable economic burden on individuals and society. Globally, misd...
Cutaneous allodynia as predictor for treatment response in chronic migraine: a cohort study
Cutaneous allodynia as predictor for treatment response in chronic migraine: a cohort study
Central sensitisation is an important mechanism in migraine chronification. It is presumed to occur in second and third or...
Relationship between alcohol and primary headaches: a systematic review and meta-analysis
Relationship between alcohol and primary headaches: a systematic review and meta-analysis
Headache is one of the most common neurological symptoms. Many previous studies have indicated a relationship between prim...
Impact of headache frequency and preventive medication failure on quality of life, functioning, and costs among individuals with migraine across several European countries: need for effective preventive treatment
Impact of headache frequency and preventive medication failure on quality of life, functioning, and costs among individuals with migraine across several European countries: need for effective preventive treatment
Data are limited regarding the combined impact of headache frequency and failure of preventive medication (efficacy and/or...
Adiponectin receptor 1-mediated stimulation of Cav3.2 channels in trigeminal ganglion neurons induces nociceptive behaviors in mice
Adiponectin receptor 1-mediated stimulation of Cav3.2 channels in trigeminal ganglion neurons induces nociceptive behaviors in mice
Adipokines, including adiponectin, are implicated in nociceptive pain; however, the underlying cellular and molecular mech...
Patients with cluster headache show signs of insomnia and sleep related stress: results from an actigraphy and self-assessed sleep study
Patients with cluster headache show signs of insomnia and sleep related stress: results from an actigraphy and self-assessed sleep study
Cluster headache (CH) is a primary headache disorder which is characterized by circadian timing of headache attacks, usual...
Advanced brain MRI may help understand the link between migraine and multiple sclerosis
Advanced brain MRI may help understand the link between migraine and multiple sclerosis
There is a clinical association between migraine and multiple sclerosis. Migraine and MS patients share similar demographi...
Headache disorders and relevant sex and socioeconomic patterns in adolescents and young adults across 204 countries and territories: an updated global analysis
Headache disorders and relevant sex and socioeconomic patterns in adolescents and young adults across 204 countries and territories: an updated global analysis
Primary headache disorders are a group of highly prevalent and disabling neurological diseases that mainly consist of migr...
Lipids, lipid-modifying drug target genes and migraine: a Mendelian randomization study
Lipids, lipid-modifying drug target genes and migraine: a Mendelian randomization study
Migraine, a prevalent headache disorder with unclear mechanisms and limited treatments, may be influenced by dyslipidemia ...
Trajectory of blood pressure after initiating anti-calcitonin gene-related peptide treatment of migraine: a target trial emulation from the veterans health administration
Trajectory of blood pressure after initiating anti-calcitonin gene-related peptide treatment of migraine: a target trial emulation from the veterans health administration
Calcitonin gene-related peptide (CGRP) is involved in migraine pathophysiology and blood pressure regulation. Although cli...
Phenotype of new daily persistent headache: subtypes and comparison to transformed chronic daily headache
Phenotype of new daily persistent headache: subtypes and comparison to transformed chronic daily headache
It is unknown whether new daily persistent headache (NDPH) is a single disorder or heterogenous group of disorders, and wh...
Identifying causal genes for migraine by integrating the proteome and transcriptome
Identifying causal genes for migraine by integrating the proteome and transcriptome
While previous genome-wide association studies (GWAS) have identified multiple risk variants for migraine, there is a lack...
Correction: Changes of migraine aura with advancing age of patients
Correction: Changes of migraine aura with advancing age of patients
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Neuroimaging in the pre-ictal or premonitory phase of migraine: a narrative review
Neuroimaging in the pre-ictal or premonitory phase of migraine: a narrative review
The premonitory phase, or prodrome, of migraine, provides valuable opportunities to study attack initiation and for treati...
Exploring sensory sensitivity, cortical excitability, and habituation in episodic migraine, as a function of age and disease severity, using the pattern-reversal task
Exploring sensory sensitivity, cortical excitability, and habituation in episodic migraine, as a function of age and disease severity, using the pattern-reversal task
Migraine is a cyclic, neurosensory disorder characterized by recurrent headaches and altered sensory processing. The latte...
Mechanisms of initiation of cortical spreading depression
Mechanisms of initiation of cortical spreading depression
There is increasing evidence from human and animal studies that cortical spreading depression (CSD) is the neurophysiologi...
Galcanezumab in patients with episodic migraine: results from the open-label period of the phase 3 PERSIST study
Galcanezumab in patients with episodic migraine: results from the open-label period of the phase 3 PERSIST study
The phase 3 randomized PERSIST study demonstrated the efficacy and tolerability of galcanezumab, a humanized anti-calciton...
Real-world effectiveness, satisfaction, and optimization of ubrogepant for the acute treatment of migraine in combination with onabotulinumtoxinA: results from the COURAGE Study
Real-world effectiveness, satisfaction, and optimization of ubrogepant for the acute treatment of migraine in combination with onabotulinumtoxinA: results from the COURAGE Study
Individuals using onabotulinumtoxinA as a preventive migraine treatment often use acute treatments for breakthrough attack...
Changes of migraine aura with advancing age of patients
Changes of migraine aura with advancing age of patients
Given the similar presentation of migraine aura and acute ischemic stroke, advancing patient age might change the characte...
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