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Mechanism of external K + sensitivity of KCNQ1 channels
Occupation of the uppermost ion-binding site of the selectivity filter of K+ channels by external K+ promotes channel acti...
A cooperative knock-on mechanism underpins Ca 2+ -selective cation permeation in TRPV channels
TRPV5 and TRPV6 are unique among TRP channels due to their high Ca2+ selectivity, while most other members of this ion cha...
Sensing its own permeant ion: KCNQ1 channel inhibition by external K +
External potassium inhibits KCNQ1 channel through a mechanism involving increased occupancy of the filter S0 site by K+o.
About hysteresis in Shaker: Response to note by Villalba-Galea
Our response points out the deficiencies in the alternative explanation proposed by Villalba-Galea to account for our find...
About hysteresis in Shaker: A note on Cowgill and Chanda
This letter proposes an alternative explanation to the work published by Cowgill and Chanda on the nature of hysteresis in...
BK channels of five different subunit combinations underlie the de novo KCNMA1 G375R channelopathy
A heterozygous BK channelopathy G375R/WT expresses five different types of channels differing in voltage activation and co...
Tweaking the catalytic efficiency of the CFTR ion channel
CFTR, unique among ABC transporters, evolved to function as an ion channel in part by optimizing the stability of the open...
A novel Hv1 inhibitor reveals a new mechanism of inhibition of a voltage-sensing domain
Zhao and colleagues use the Hv1 channel to study drugs that modulate channel activity by binding to the voltage-sensing do...
HIFs: New arginine mimic inhibitors of the Hv1 channel with improved VSD–ligand interactions
Zhao et al. leverage the analysis of local conformational changes in a mutant Hv1 channel to inform the design of new inhi...
L-type channel inactivation balances the increased peak calcium current due to absence of Rad in cardiomyocytes
Ahern et al. show that the absence of Rad increases peak L-type calcium influx independently of β-adrenergic receptor sign...
Loss of crossbridge inhibition drives pathological cardiac hypertrophy in patients harboring the TPM1 E192K mutation
Sewanan et al. studied a mutation to cardiac tropomyosin that causes hypertrophic cardiomyopathy. Computational models, in...
Conformations of voltage-sensing domain III differentially define Na V channel closed- and open-state inactivation
Angsutararux et al. propose that the voltage-sensing domains of repeats III and IV of NaV channels regulate state-dependen...
Evidence that toxin resistance in poison birds and frogs is not rooted in sodium channel mutations and may rely on “toxin sponge” proteins
Some poisonous animals produce toxins that affect Na+ channel function yet avoid autointoxication. Abderemane-Ali et al. s...
Computational study of non-conductive selectivity filter conformations and C-type inactivation in a voltage-dependent potassium channel
Li et al. carry out molecular dynamics simulations of the K+ channels Shaker and KcsA to test whether a structural constri...
State-dependent inhibition of BK channels by the opioid agonist loperamide
Vouga et al. show that the opioid receptor agonist loperamide is an inhibitor of large-conductance Ca2+-activated K+ (BK) ...
Widening the scope of constriction
JGP modeling study suggests that selectivity filter constriction is a plausible mechanism for C-type inactivation of the S...
Norfluoxetine inhibits TREK-2 K2P channels by multiple mechanisms including state-independent effects on the selectivity filter gate
Proks et al. show that the antidepressant norfluoxetine affects the behavior of TREK-2 two-pore domain K+ channels by regu...
Mutation of a conserved glutamine residue does not abolish desensitization of acid-sensing ion channel 1
Rook et al. assess how mutations in acid-sensing ion channel 1 (ASIC1) affect channel desensitization. They establish that...
Cooperative binding ensures the obligatory melibiose/Na + cotransport in MelB
Hariharan and Guan find that binding of either melibiose or Na+ to their transporter, MelB, may favor MelB open states, wh...
Application of fluorescent dextrans to the brain surface under constant pressure reveals AQP4-independent solute uptake
Smith et al. use a novel technique for direct measurement of solute transport from cerebrospinal fluid to brain interstiti...
ENaC and ROMK channels in the connecting tubule regulate renal K + secretion
Yang et al. study changes in the activity of the kidney ENaC and ROMK channels in response to variations in K+ levels in t...
Unraveling the mysteries of the titin–N2A signalosome
The sarcomeric titin springs and accessory proteins modulate muscle force and mechanical signaling at the N2A signalosome.
Cardiac mechanical efficiency is preserved in primary cardiac hypertrophy despite impaired mechanical function
Han et al. study the effect of primary cardiac hypertrophy on cardiac mechano-energetics. Using isolated cardiac tissues, ...
A TREK inhibitor takes multiple tracks
Single-channel recordings reveal that norfluoxetine inhibits the two-pore domain K+ channel TREK-2 by a complex array of m...
Zinc binding alters the conformational dynamics and drives the transport cycle of the cation diffusion facilitator YiiP
Lopez-Redondo et al. use cryo-EM and molecular dynamics to evaluate the effects of Zn2+ binding on the conformation and dy...
Intercalated disk nanoscale structure regulates cardiac conduction
Moise et al. develop a finite element model of the intercalated disk (ID) that takes into account the nanoscale structure....
Cardiac MyBP-C phosphorylation regulates the Frank–Starling relationship in murine hearts
Cardiac myosin-binding protein C (cMyBP-C) is thought to regulate cardiac muscle and heart contraction. Hanft et al. show ...
cMyBPC phosphorylation modulates the effect of omecamtiv mecarbil on myocardial force generation
Mamidi et al. investigate the effect of cardiac myosin-binding protein C (cMyBPC) phosphorylation on the response to omeca...
Novel insights into sarcomere regulatory systems control of cardiac thin filament activation
This review focuses on thin filament regulatory mechanisms with emphasis on cardiac-specific mechanisms in the three-state...
The N2A region of titin has a unique structural configuration
Stronczek et al. analyze the structure of the titin-N2A poly-Ig segment, a key signaling element in the sarcomere. They re...
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