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Loss of PTPN21 disrupted mitochondrial metabolic homeostasis and aggravated experimental pulmonary fibrosis
Loss of PTPN21 disrupted mitochondrial metabolic homeostasis and aggravated experimental pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a high-mortality lung disease with unclear pathogenesis. Convincing evidence sugges...
Silencing SMAD4 inhibits inflammation and ferroptosis in asthma by blocking the IL-17A signaling pathway
Silencing SMAD4 inhibits inflammation and ferroptosis in asthma by blocking the IL-17A signaling pathway
The TGF-β/SMAD signaling pathway is crucial in the pathogenesis of asthma. However, SMAD family member 4 (SMAD4), a k...
T follicular helper cell is essential for M2 macrophage polarization and pulmonary vascular remodeling in hypoxia-induced pulmonary hypertension
T follicular helper cell is essential for M2 macrophage polarization and pulmonary vascular remodeling in hypoxia-induced pulmonary hypertension
Hypoxia-induced pulmonary hypertension (HPH) is a subgroup of type 3 pulmonary hypertension that may cause early right ven...
IL-33-experienced group 2 innate lymphoid cells in the lung are poised to enhance type 2 inflammation selectively in adult female mice
IL-33-experienced group 2 innate lymphoid cells in the lung are poised to enhance type 2 inflammation selectively in adult female mice
While Th2 adaptive immunity has long been considered to orchestrate type 2 inflammation in the allergic lung, group 2 inna...
Human adenovirus type 7 (HAdV-7) infection induces pulmonary vascular endothelial injury through the activation of endothelial autophagy
Human adenovirus type 7 (HAdV-7) infection induces pulmonary vascular endothelial injury through the activation of endothelial autophagy
HAdV-7 is a prevalent pathogen that can cause severe pneumonia in children. Previous studies have shown a significant incr...
Association between humidity and respiratory health: the 2016–2018 Korea National Health and Nutrition Examination Survey
Association between humidity and respiratory health: the 2016–2018 Korea National Health and Nutrition Examination Survey
Ambient humidity has a significant impact on respiratory health and influences disease and symptoms. However, large-scale ...
Palmitoleic acid inhibits Pseudomonas aeruginosa quorum sensing activation and protects lungs from infectious injury
Palmitoleic acid inhibits Pseudomonas aeruginosa quorum sensing activation and protects lungs from infectious injury
Unsaturated fatty acids targeting quorum sensing (QS) system have shown potential application in reducing bacterial virule...
Toll-like receptor activation induces airway obstruction and hyperresponsiveness in guinea pigs
Toll-like receptor activation induces airway obstruction and hyperresponsiveness in guinea pigs
Microbial infections, particularly those caused by rhinovirus (RV) and respiratory syncytial virus (RSV), are major trigge...
Association between alcohol consumption and risk of developing tuberculosis in patients with diabetes: a nationwide retrospective cohort study
Association between alcohol consumption and risk of developing tuberculosis in patients with diabetes: a nationwide retrospective cohort study
Diabetes mellitus (DM) and alcohol consumption are risk factors for tuberculosis (TB). We investigated the association bet...
An optimized QIAzol-based protocol for simultaneous miRNA, RNA, and protein isolation from precision-cut lung slices (PCLS)
An optimized QIAzol-based protocol for simultaneous miRNA, RNA, and protein isolation from precision-cut lung slices (PCLS)
Precision-cut lung slices (PCLS) are ex vivo models with preserved lung cell populations and maintained tissue architectur...
Inhibition of IRE1α/XBP1 axis alleviates LPS-induced acute lung injury by suppressing TXNIP/NLRP3 inflammasome activation and ERK/p65 signaling pathway
Inhibition of IRE1α/XBP1 axis alleviates LPS-induced acute lung injury by suppressing TXNIP/NLRP3 inflammasome activation and ERK/p65 signaling pathway
Acute lung injury or acute respiratory distress syndrome (ALI/ARDS) is a devastating clinical syndrome with high incidence...
Intestinal IFNα4 promotes 15-HETE diet-induced pulmonary hypertension
Intestinal IFNα4 promotes 15-HETE diet-induced pulmonary hypertension
Pulmonary arterial hypertension (PAH) is characterized by the remodeling of the pulmonary vascular bed leading to elevatio...
Serum proteome profiling reveals HGFA as a candidate biomarker for pulmonary arterial hypertension
Serum proteome profiling reveals HGFA as a candidate biomarker for pulmonary arterial hypertension
Identification and validation of potential biomarkers could facilitate the identification of pulmonary arterial hypertensi...
Pulmonary lymphangiomatosis: insights into an ultra-rare disease
Pulmonary lymphangiomatosis: insights into an ultra-rare disease
Pulmonary lymphangiomatosis (PL) is an ultrarare disease characterized by diffuse infiltration of the lung, pleura and/or ...
Acute exacerbation of progressive pulmonary fibrosis: incidence and outcomes
Acute exacerbation of progressive pulmonary fibrosis: incidence and outcomes
Few data are available on acute exacerbation (AE) in patients with progressive pulmonary fibrosis (PPF) besides idiopathic...
Association between metabolic syndrome and chronic obstructive pulmonary disease development in young individuals: a nationwide cohort study
Association between metabolic syndrome and chronic obstructive pulmonary disease development in young individuals: a nationwide cohort study
The association between metabolic syndrome (MetS) and chronic obstructive pulmonary disease (COPD) has not been studied we...
Therapeutic effects of melatonin on the lungs of rats exposed to passive smoking
Therapeutic effects of melatonin on the lungs of rats exposed to passive smoking
Passive smoke has a significant impact on lung function and constitutes a critical public health issue, as smoking generat...
Association of asthma and bronchiectasis: Mendelian randomization analyses and observational study
Association of asthma and bronchiectasis: Mendelian randomization analyses and observational study
Previous studies have demonstrated that asthma is closely associated with bronchiectasis, however, the causal relationship...
Knockdown of the long noncoding RNA VSIG2-1:1 promotes the angiogenic ability of human pulmonary microvascular endothelial cells by activating the VEGF/PI3K/AKT pathway
Knockdown of the long noncoding RNA VSIG2-1:1 promotes the angiogenic ability of human pulmonary microvascular endothelial cells by activating the VEGF/PI3K/AKT pathway
Abnormal pulmonary vascular development poses significant clinical challenges for infants with bronchopulmonary dysplasia ...
Prognostic risk prediction model for patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD): a systematic review and meta-analysis
Prognostic risk prediction model for patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD): a systematic review and meta-analysis
Chronic obstructive pulmonary disease (COPD) is a prevalent respiratory condition and a leading cause of mortality, with a...
Mortality after treatment of malignant pleural effusions with indwelling pleural catheters versus chemical pleurodesis: a population-based study
Mortality after treatment of malignant pleural effusions with indwelling pleural catheters versus chemical pleurodesis: a population-based study
Little is known about patient outcomes following treatment of malignant pleural effusions (MPE) in the real-world setting....
Euphorbium compositum SN improves the innate defenses of the airway mucosal barrier network during rhinovirus infection
Euphorbium compositum SN improves the innate defenses of the airway mucosal barrier network during rhinovirus infection
Rhinoviruses (RV) are the major cause of common colds in healthy individuals and are associated with acute exacerbations i...
Lactate activates ER stress to promote alveolar epithelial cells apoptosis in pulmonary fibrosis
Lactate activates ER stress to promote alveolar epithelial cells apoptosis in pulmonary fibrosis
Pulmonary fibrosis (PF) is a chronic, progressive lung disease characterized by fibroblast proliferation, extensive extrac...
Computed tomography morphological assessments of central airways in interstitial lung abnormalities and idiopathic pulmonary fibrosis
Computed tomography morphological assessments of central airways in interstitial lung abnormalities and idiopathic pulmonary fibrosis
Little is known about whether central airway morphological changes beyond traction bronchiectasis develop and affect clini...
Atomized inhalation of indocyanine green in thoracoscopic surgery for intralobar pulmonary sequestration: a multicenter study
Atomized inhalation of indocyanine green in thoracoscopic surgery for intralobar pulmonary sequestration: a multicenter study
Investigate the safety and efficacy of preoperative atomization inhalation of indocyanine green (ICG) solution in precise ...
Repeated inhalation of GM-CSF by nonhuman primates induces bronchus-associated lymphoid tissue along the lower respiratory tract
Repeated inhalation of GM-CSF by nonhuman primates induces bronchus-associated lymphoid tissue along the lower respiratory tract
Repeated inhalation of granulocyte-macrophage colony-stimulating factor (GM-CSF) was recently approved in Japan as a treat...
Serum soluble isoform of receptor for advanced glycation end product is a predictive biomarker for acute exacerbation of idiopathic pulmonary fibrosis: a German and Japanese cohort study
Serum soluble isoform of receptor for advanced glycation end product is a predictive biomarker for acute exacerbation of idiopathic pulmonary fibrosis: a German and Japanese cohort study
The receptor for advanced glycation end product (RAGE) is a transmembrane receptor accelerating a pro-inflammatory signal....
Clinical and biologic profiles of patients with acute respiratory distress syndrome by prevalence of chronic obstructive pulmonary disease or emphysema; a cohort study
Clinical and biologic profiles of patients with acute respiratory distress syndrome by prevalence of chronic obstructive pulmonary disease or emphysema; a cohort study
Acute respiratory distress syndrome (ARDS) is characterized by diffuse lung injury. The impact of pre-existing chronic obs...
Activation of LXR signaling ameliorates apoptosis of alveolar epithelial cells in Bronchopulmonary dysplasia
Activation of LXR signaling ameliorates apoptosis of alveolar epithelial cells in Bronchopulmonary dysplasia
Liver X receptors (LXRs) are specialized nuclear receptors essential for maintaining cholesterol homeostasis, modulating L...
Research progress of mitochondrial dysfunction induced pyroptosis in acute lung injury
Research progress of mitochondrial dysfunction induced pyroptosis in acute lung injury
Acute lung injury (ALI) is a common critical respiratory disease in clinical practice, especially in the ICU, with a high ...
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