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Deconstructing organs: From decellularized organs, and stem cells niche to constructed organoids and engineering new organs
The Hox gene cluster is an iconic example of evolutionary conservation between divergent animal lineages, providing eviden...
Strategic use of organoids and organs-on-chip as biomimetic tools
The technology of generation and development of organoids and organs-on-a-chip (OOC) contributes to the in vitro study of ...
Regulatory mechanisms of stem cell differentiation: Biotechnological applications for neurogenesis
In the past decades, research related to the development of neuroprotective drugs has quickly advanced and highlighted sev...
Application of stem cells in engineered vascular graft and vascularized organs
Over the past few decades, research on and the application of stem cells has gradually become a highly attractive topic in...
Microfluidic organoids-on-a-chip: The future of human models
Microfluidics is a technology that allows to manipulate fluids by performing a high control on their flow. In microfluidic...
Retinal organoids from human-induced pluripotent stem cells: From studying retinal dystrophies to early diagnosis of Alzheimer’s and Parkinson’s disease
The fully developed neural retina comprises high-specialized cells that transform light stimuli into electrochemical signa...
From temporal patterning to neuronal connectivity in Drosophila type I neuroblast lineages
During Drosophila neurogenesis, a small pool of neural progenitor cells generates a diverse population of neurons. Initial...
The Drivers of Diversity: Integrated genetic and hormonal cues regulate neural diversity
The major function of the brain is to translate/integrate neuronal functions to produce behaviors, making the complexity o...
Time to see: How temporal identity factors specify the developing mammalian retina
Multicellular organisms develop as 4 dimensional spatiotemporal arrays to ultimately form cohesive organs and tissues with...
Setting the clock of neural progenitor cells during mammalian corticogenesis
One of the biggest challenges in neuroscience is to understand how developmental programs instruct the generation of enorm...
Generating neural diversity through spatial and temporal patterning
There are many ways of defining a cell type. A cell can be unique because of its function, morphology, or molecular charac...
Temporal transitions in the postembryonic nervous system of the nematode Caenorhabditis elegans: Recent insights and open questions
Volume 142, June 2023, Pages 67-80Author links open overlay panel, AbstractAfter the generation, differentiation and integ...
Temporal control of neuronal wiring
Volume 142, June 2023, Pages 81-90Author links open overlay panel, AbstractWiring an animal brain is a complex process inv...
Mitochondria: Key modulators of skeletal muscle remodeling
The objective of this study was to test if resistance training induced muscle hypertrophy leads to greater strength gains....
Impacts of altered exercise volume, intensity, and duration on the activation of AMPK and CaMKII and increases in PGC-1α mRNA
The ability of aerobic exercise training to promote mitochondrial biogenesis – “the making of new components of the mitoch...
Mitochondrial-derived vesicles in skeletal muscle remodeling and adaptation
Skeletal muscle remodeling and regeneration are achieved through the fine regulation of converging pathways that ultimatel...
Implications of mitochondrial fusion and fission in skeletal muscle mass and health
Skeletal muscle, the most extensive body tissue accounting for 40% of our body weight, plays critical roles in eating, bre...
Mitochondrial Apoptotic Signaling Involvement in Remodeling During Myogenesis and Skeletal Muscle Atrophy
Apoptosis is a conserved physiological mechanism responsible for the elimination of dysfunctional, damaged, and/or unneces...
Gastrulation morphogenesis in synthetic systems
The field of developmental biology has been revolutionized by the advent of stem cell-based modeling of embryonic developm...
Mapping and exploring the organoid state space using synthetic biology
Active fluid transport across epithelial monolayers is emerging as a major driving force of tissue morphogenesis in a vari...
Synthetic developmental biology: New tools to deconstruct and rebuild developmental systems
For many biologists, embryogenesis is the greatest show on earth. The rapid development from a single cell to a complex, p...
Self-organized collective cell behaviors as design principles for synthetic developmental biology
Over the past two decades, molecular cell biology has graduated from a mostly analytic science to one with substantial syn...
Force: A messenger of axon outgrowth
Volume 140, 15 May 2023, Pages 3-12Author links open overlay panelAbstractThe axon is a sophisticated macromolecular machi...
Mechanics of axon growth and damage: A systematic review of computational models
Mechanical forces influence the nervous system across both temporal and spatial scales. At longer time scales, mechanical ...
The role of mechanics in axonal stability and development
Neuronal cells have evolved to span long distances within an organism by extending thin tubular protrusions called axons a...
Microtubule remodelling as a driving force of axon guidance and pruning
The nervous system governs vital functions as well as complex behaviours enabling animals to interact with their environme...
Spatial confinement: A spur for axonal growth
Brain tissues and dissociated neurons in culture dishes represent diametrically opposed systems on the complexity scale. B...
Mechanical regulation of synapse formation and plasticity
Volume 140, 15 May 2023, Pages 82-89Author links open overlay panelHighlights•BAR-domain proteins deform the dendritic mem...
Biomechanical models and mechanisms of cellular morphogenesis and cerebral cortical expansion and folding
Volume 140, 15 May 2023, Pages 90-104Author links open overlay panelHighlights•Mechanical tension mediated by the cytoskel...
Synapse pathology in Alzheimer’s disease
Volume 139, April 2023, Pages 13-23Author links open overlay panelHighlights•Loss of synapses and changes in their morphol...
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