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Editorial: Special issue SCDB “Cell death and survival”: Cell death and resilience in health and disease
Editorial: Special issue SCDB “Cell death and survival”: Cell death and resilience in health and disease
H. Kalkavan et al.Non-lethal outcomes of engaging regulated cell death pathways in cancerNat. Cancer(2023)N. Popgeorgiev e...
Shedding light on mitochondrial outer-membrane permeabilization and membrane potential: State of the art methods and biosensors
Shedding light on mitochondrial outer-membrane permeabilization and membrane potential: State of the art methods and biosensors
Membrane structural integrity is essential for optimal mitochondrial function. These organelles produce the energy needed ...
Death and survival from executioner caspase activation
Death and survival from executioner caspase activation
Caspases (Cysteine-ASPartic proteASES) are a group of proteases that cleave their substrates after specific short tetrapep...
An emerging role for the endoplasmic reticulum in stress granule biogenesis
An emerging role for the endoplasmic reticulum in stress granule biogenesis
Stress granules (SGs) are a prominently studied member of a family of ribonucleoprotein (RNP) granules evident at many pha...
Composition and function of stress granules and P-bodies in plants
Composition and function of stress granules and P-bodies in plants
Stress Granules (SGs) and Processing-bodies (P-bodies) are biomolecular condensates formed in the cell with the highly con...
The implications of physiological biomolecular condensates in amyotrophic lateral sclerosis
The implications of physiological biomolecular condensates in amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting 1 in 50,000 individuals per year and is...
The vagus nerve in cardiovascular physiology and pathophysiology: From evolutionary insights to clinical medicine
The vagus nerve in cardiovascular physiology and pathophysiology: From evolutionary insights to clinical medicine
The parasympathetic nervous system via the vagus nerve exerts profound influence over the heart. Together with the sympath...
The gut-brain axis and cognitive control: A role for the vagus nerve
The gut-brain axis and cognitive control: A role for the vagus nerve
‘Survival of the fittest’ is driven by a species’ constant adaptation to a changing environment, which requires both aware...
Molecular cell types as functional units of the efferent vagus nerve
Molecular cell types as functional units of the efferent vagus nerve
The vagus nerve, a cranial nerve named for its “wandering” path from brainstem to bowel, is a vital conduit for brain-body...
Vagal pathways for systemic regulation of glucose metabolism
Vagal pathways for systemic regulation of glucose metabolism
Glucose is undoubtedly the primary energy fuel for practically all tissues in mammals. Because both hypo- and hyperglycemi...
Collective mitochondrial dynamics resolve conflicting cellular tensions: From plants to general principles
Collective mitochondrial dynamics resolve conflicting cellular tensions: From plants to general principles
Mitochondria play diverse and essential roles in eukaryotic cells, and plants are no exception. Plant mitochondria have se...
Apoptotic signaling: Beyond cell death
Apoptotic signaling: Beyond cell death
Our bodies are societies where survival of the whole is achieved at the expense of individuals. From the moment we are con...
Immunogenic cell stress and death in the treatment of cancer
Immunogenic cell stress and death in the treatment of cancer
The successful treatment of oncological malignancies which results in long-term disease control or the complete eradicatio...
Development and regeneration of the vagus nerve
Development and regeneration of the vagus nerve
For centuries, the vagus nerve has been revered as an anatomical wonder for its structural complexity. It extends a multit...
Vagal sensory pathway for the gut-brain communication
Vagal sensory pathway for the gut-brain communication
The vagal sensory pathway plays a critical role in conveying internal bodily states to the brain. Vagal sensory neurons re...
Selective induction of programmed cell death using synthetic biology tools
Selective induction of programmed cell death using synthetic biology tools
Available online 17 August 2023Author links open overlay panel, AbstractRegulated cell death (RCD) controls the removal of...
Plasma membrane repair empowers the necrotic survivors as innate immune modulators
Plasma membrane repair empowers the necrotic survivors as innate immune modulators
Since the first cells on Earth about 4 billion years ago, the cell plasma membrane (PM) has served as the essential barrie...
Proteotoxic stress and the ubiquitin proteasome system
Proteotoxic stress and the ubiquitin proteasome system
The ubiquitin proteasome system maintains protein homeostasis by regulating the breakdown of misfolded proteins, thereby p...
Emerging roles of DNA repair factors in the stability of centromeres
Emerging roles of DNA repair factors in the stability of centromeres
Centromeres are chromosomal elements made up of satellite DNA, which are essential for the correct segregation of chromoso...
The implications of satellite DNA instability on cellular function and evolution
The implications of satellite DNA instability on cellular function and evolution
Satellite DNA refers to long arrays of noncoding tandem repeat sequences that are abundant in eukaryotic genomes. Satellit...
DNA strand breaks at centromeres: Friend or foe?
DNA strand breaks at centromeres: Friend or foe?
Centromeres are large structural regions in the genomic DNA, which are essential for accurately transmitting a complete se...
The mechanisms and roles of mitochondrial dynamics in C. elegans
The mechanisms and roles of mitochondrial dynamics in C. elegans
Available online 31 October 2023Author links open overlay panel, Highlights•Mitochondrial fission in C. elegans is mediate...
Dynamic interplay between human alpha-satellite DNA structure and centromere functions
Dynamic interplay between human alpha-satellite DNA structure and centromere functions
Human centromeres consist of repetitive alpha-satellite DNA hierarchically organized in megabase-long arrays called higher...
Persister cell plasticity in tumour drug resistance
Persister cell plasticity in tumour drug resistance
Despite the continued development of effective pharmacological agents for the treatment of cancer, the emergence of therap...
Thrombospondin proteins – Versatile extracellular proteins with multiple biological functions
Thrombospondin proteins – Versatile extracellular proteins with multiple biological functions
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Thrombospondins in the tumor microenvironment
Thrombospondins in the tumor microenvironment
Solid tumors induce a richly vascularized stroma that promotes cellular growth and invasion [1]. In some cancers, such as ...
Molecular evolution of the Thrombospondin superfamily
Molecular evolution of the Thrombospondin superfamily
Volume 155, Part B, 1 March 2024, Pages 12-21Author links open overlay panel, AbstractThrombospondins (TSPs) are multidoma...
Emerging functions of thrombospondin-1 in immunity
Emerging functions of thrombospondin-1 in immunity
Volume 155, Part B, 1 March 2024, Pages 22-31Author links open overlay panel, AbstractThrombospondin-1 is a secreted matri...
Thrombospondin-1 in vascular development, vascular function, and vascular disease
Thrombospondin-1 in vascular development, vascular function, and vascular disease
Thrombospondin-1 (TSP1) is a member of canonical thrombospondins subfamily [1], consisting of five members TSP1–5. TSP1 or...
Thrombospondin-1 in drug activity and tumor response to therapies
Thrombospondin-1 in drug activity and tumor response to therapies
The composition, mechanical properties and biological activities of the TME have a profound impact on different aspects of...
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