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Disruption of Mitochondrial Quality Control in Inherited Metabolic Disorders
Disruption of Mitochondrial Quality Control in Inherited Metabolic Disorders
Inherited metabolic disorders (IMDs) are genetic disorders often characterized by the accumulation of toxic metabolites in...
Exploring the Mechanisms and Therapeutic Approaches of Mitochondrial Dysfunction in Alzheimer’s Disease: An Educational Literature Review
Exploring the Mechanisms and Therapeutic Approaches of Mitochondrial Dysfunction in Alzheimer’s Disease: An Educational Literature Review
Alzheimer’s disease (AD) presents a significant challenge to global health. It is characterized by progressive cogni...
Activation of P2X7R Inhibits Proliferation and Promotes the Migration and Differentiation of Schwann Cells
Activation of P2X7R Inhibits Proliferation and Promotes the Migration and Differentiation of Schwann Cells
In the vertebrate nervous system, myelination of nerve fibers is crucial for the rapid propagation of action potentials th...
Curculigoside Regulates Apoptosis and Oxidative Stress Against Spinal Cord Injury by Modulating the Nrf-2/NQO-1 Signaling Pathway In Vitro and In Vivo
Curculigoside Regulates Apoptosis and Oxidative Stress Against Spinal Cord Injury by Modulating the Nrf-2/NQO-1 Signaling Pathway In Vitro and In Vivo
Spinal cord injury (SCI) is a severe neurological disorder that can lead to paralysis or death. Oxidative stress during SC...
TUBB4A Inhibits Glioma Development by Regulating ROS-PINK1/Parkin-Mitophagy Pathway
TUBB4A Inhibits Glioma Development by Regulating ROS-PINK1/Parkin-Mitophagy Pathway
Glioma is a refractory malignant tumor with a powerful capacity for invasiveness and a poor prognosis. This study aims to ...
The Use of Identified Hypoxia-related Genes to Generate Models for Predicting the Prognosis of Cerebral Ischemia‒reperfusion Injury and Developing Treatment Strategies
The Use of Identified Hypoxia-related Genes to Generate Models for Predicting the Prognosis of Cerebral Ischemia‒reperfusion Injury and Developing Treatment Strategies
Cerebral ischemia‒reperfusion injury (CIRI) is a type of secondary brain damage caused by reperfusion after ischemic...
The Potential of Mitochondrial Therapeutics in the Treatment of Oxidative Stress and Inflammation in Aging
The Potential of Mitochondrial Therapeutics in the Treatment of Oxidative Stress and Inflammation in Aging
Mitochondria are central to cellular energy production, and their dysfunction is a major contributor to oxidative stress a...
Mild Blast Exposure Dysregulates Metabolic Pathways and Correlation Networking as Evident from LC–MS-Based Plasma Profiling
Mild Blast Exposure Dysregulates Metabolic Pathways and Correlation Networking as Evident from LC–MS-Based Plasma Profiling
Blast-induced trauma is emerging as a serious threat due to its wide pathophysiology where not only the brain but also a s...
Monosome Stalls the Translation Process Mediated by IGF2BP in Arcuate Nucleus for Puberty Onset Delay
Monosome Stalls the Translation Process Mediated by IGF2BP in Arcuate Nucleus for Puberty Onset Delay
Puberty onset through hypothalamic-pituitary-gonad (HPG) axis as an important reproductive event in postnatal development ...
Causal Relationships Between Retinal Diseases and Psychiatric Disorders Have Implications for Precision Psychiatry
Causal Relationships Between Retinal Diseases and Psychiatric Disorders Have Implications for Precision Psychiatry
Observational studies and clinical trials have reported potential associations between retinal diseases and psychiatric di...
Insulin-Like Growth Factor Signaling in Alzheimer’s Disease: Pathophysiology and Therapeutic Strategies
Insulin-Like Growth Factor Signaling in Alzheimer’s Disease: Pathophysiology and Therapeutic Strategies
Alzheimer’s disease (AD) is the leading cause of dementia among the elderly population, posing a significant public ...
A Novel m.1636A > G Variant in Mitochondrial TV Gene Might Cause New Phenotype of Mitochondrial Disease in a 2-Year Old Chinese Boy
A Novel m.1636A > G Variant in Mitochondrial TV Gene Might Cause New Phenotype of Mitochondrial Disease in a 2-Year Old Chinese Boy
Pathogenic variants of mitochondrial DNA (mtDNA) are associated with a large number of heterogeneous diseases involving mu...
Identification of Immune-Related Biomarkers of Schizophrenia in the Central Nervous System Using Bioinformatic Methods and Machine Learning Algorithms
Identification of Immune-Related Biomarkers of Schizophrenia in the Central Nervous System Using Bioinformatic Methods and Machine Learning Algorithms
Schizophrenia is a disastrous mental disorder. Identification of diagnostic biomarkers and therapeutic targets is of signi...
17β-Trenbolone Exposure Enhances Muscle Activity and Exacerbates Parkinson’s Disease Progression in Male Mice
17β-Trenbolone Exposure Enhances Muscle Activity and Exacerbates Parkinson’s Disease Progression in Male Mice
Parkinson’s disease (PD) ranks as the second most prevalent neurodegenerative disorder, and while the neuroprotectiv...
Investigation of Spinocerebellar Ataxia (SCA) Disease in Iranian Patients and Accurate Trinucleotide Repeat Detection in the SCA3 by TP-PCR Method
Investigation of Spinocerebellar Ataxia (SCA) Disease in Iranian Patients and Accurate Trinucleotide Repeat Detection in the SCA3 by TP-PCR Method
SCA (spinocerebellar ataxia) which is autosomal dominantly transferred is a subset of inherited cerebellar ataxia. These p...
Downregulation of Fidgetin-Like 2 Increases Microglial Function: The Relationship Between Microtubules, Morphology, and Activity
Downregulation of Fidgetin-Like 2 Increases Microglial Function: The Relationship Between Microtubules, Morphology, and Activity
The microtubule cytoskeleton regulates microglial morphology, motility, and effector functions. The microtubule-severing e...
Microglia Promote Lymphangiogenesis Around the Spinal Cord Through VEGF-C/VEGFR3-Dependent Autophagy and Polarization After Acute Spinal Cord Injury
Microglia Promote Lymphangiogenesis Around the Spinal Cord Through VEGF-C/VEGFR3-Dependent Autophagy and Polarization After Acute Spinal Cord Injury
Reducing secondary injury is a key focus in the field of spinal cord injury (SCI). Recent studies have revealed the role o...
Dose-Dependent Attenuation of the Efficacy of Clitoria ternatea by Cobalt Oxide Nanoparticles Against Diabetes-Induced Cognitive Impairment
Dose-Dependent Attenuation of the Efficacy of Clitoria ternatea by Cobalt Oxide Nanoparticles Against Diabetes-Induced Cognitive Impairment
Diabetes mellitus is a metabolic disorder caused by insulin deficiency, insulin resistance, genetic alterations, and oxida...
Single-Cell Cortical Transcriptomics Reveals Common and Distinct Changes in Cell-Cell Communication in Alzheimer’s and Parkinson’s Disease
Single-Cell Cortical Transcriptomics Reveals Common and Distinct Changes in Cell-Cell Communication in Alzheimer’s and Parkinson’s Disease
Alzheimer's disease (AD) and Parkinson's disease (PD) cause significant neuronal loss and severely impair daily li...
Identification of Autophagy-Related Genes in Patients with Acute Spinal Cord Injury and Analysis of Potential Therapeutic Targets
Identification of Autophagy-Related Genes in Patients with Acute Spinal Cord Injury and Analysis of Potential Therapeutic Targets
Autophagy has been implicated in the pathogenesis and progression of spinal cord injury (SCI); however, its specific mecha...
Comparative Neuroprotective Potential of Nanoformulated and Free Resveratrol Against Cuprizone-Induced Demyelination in Rats
Comparative Neuroprotective Potential of Nanoformulated and Free Resveratrol Against Cuprizone-Induced Demyelination in Rats
Demyelination is a frequent yet crippling neurological disease associated with multiple sclerosis (MS). The cuprizone (CZ)...
Single-Nucleus Landscape of Glial Cells and Neurons in Alzheimer’s Disease
Single-Nucleus Landscape of Glial Cells and Neurons in Alzheimer’s Disease
Alzheimer’s disease (AD) is a neurodegenerative disease with a projected significant increase in incidence. Therefor...
Effect of Long-Term Tai Chi Therapy on the Immune-Inflammatory Pathway in Patients with Schizophrenia with Antipsychotic-Stabilized
Effect of Long-Term Tai Chi Therapy on the Immune-Inflammatory Pathway in Patients with Schizophrenia with Antipsychotic-Stabilized
The primary objective of this study was to explore the influence of prolonged (24 weeks) supplementary Tai Chi th...
Comprehensive Analysis and In Vitro Verification of Endothelial-Mesenchymal Transition-Related Genes in Moyamoya Disease
Comprehensive Analysis and In Vitro Verification of Endothelial-Mesenchymal Transition-Related Genes in Moyamoya Disease
Moyamoya disease (MMD) is a rare, chronic, and progressive cerebrovascular disorder with unclear underlying causes and mec...
A Disease Hidden in Plain Sight: Pathways and Mechanisms of Neurological Complications of Post-acute Sequelae of COVID-19 (NC-PASC)
A Disease Hidden in Plain Sight: Pathways and Mechanisms of Neurological Complications of Post-acute Sequelae of COVID-19 (NC-PASC)
The global impact of coronavirus disease 2019 (COVID-19) marked by numerous pandemic peaks is attributed to its high varia...
Gut Microbiota-Induced Modulation of the Central Nervous System Function in Parkinson’s Disease Through the Gut-Brain Axis and Short-Chain Fatty Acids
Gut Microbiota-Induced Modulation of the Central Nervous System Function in Parkinson’s Disease Through the Gut-Brain Axis and Short-Chain Fatty Acids
Recent insights into Parkinson’s disease (PD), a progressive neurodegenerative disorder, suggest a significant influ...
Dihydroergotamine and Bromocriptine: Potential Drugs for the Treatment of Major Depressive Disorder and Alzheimer’s Disease Comorbidity
Dihydroergotamine and Bromocriptine: Potential Drugs for the Treatment of Major Depressive Disorder and Alzheimer’s Disease Comorbidity
Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease that is characterized by memory loss and co...
The Voltage-Gated Calcium Channel α2δ Subunit in Neuropathic Pain
The Voltage-Gated Calcium Channel α2δ Subunit in Neuropathic Pain
Neuropathic pain (NP) is a chronic pain caused by injury or disease of the somatosensory nervous system, or it can be dire...
Selegiline Improves Cognitive Impairment in the Rat Model of Alzheimer’s Disease
Selegiline Improves Cognitive Impairment in the Rat Model of Alzheimer’s Disease
Alzheimer’s disease (AD) is a progressive neurological disorder characterized by cognitive decline. This study was u...
Neurons Specialize in Presynaptic Autophagy: A Perspective to Ameliorate Neurodegeneration
Neurons Specialize in Presynaptic Autophagy: A Perspective to Ameliorate Neurodegeneration
The efficient and prolonged neurotransmission is reliant on the coordinated action of numerous synaptic proteins in the pr...
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