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Application of CRISPR/Cas9 System in the Treatment of Alzheimer’s Disease and Neurodegenerative Diseases
Application of CRISPR/Cas9 System in the Treatment of Alzheimer’s Disease and Neurodegenerative Diseases
Alzheimer’s, Parkinson’s, and Huntington’s are some of the most common neurological disorders, which aff...
Pharmacological Evidence of Eugenia Brasiliensis Leaves in a Reserpine-Induced Fibromyalgia Model: Antinociceptive, Emotional, Anti-Inflammatory, and Neurotrophic Effects
Pharmacological Evidence of Eugenia Brasiliensis Leaves in a Reserpine-Induced Fibromyalgia Model: Antinociceptive, Emotional, Anti-Inflammatory, and Neurotrophic Effects
Fibromyalgia (FM) is a painful chronic condition that significantly impacts the quality of life, posing challenges for cli...
NFATc4 Knockout Promotes Neuroprotection and Retinal Ganglion Cell Regeneration After Optic Nerve Injury
NFATc4 Knockout Promotes Neuroprotection and Retinal Ganglion Cell Regeneration After Optic Nerve Injury
Retinal ganglion cells (RGCs), neurons transmitting visual information via the optic nerve, fail to regenerate their axons...
Dose-Ranging Effects of the Intracerebral Administration of Atsttrin in Experimental Model of Parkinson’s Disease Induced by 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in Mice
Dose-Ranging Effects of the Intracerebral Administration of Atsttrin in Experimental Model of Parkinson’s Disease Induced by 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in Mice
Parkinson’s disease is one of the most common neurodegenerative disorders characterized by a multitude of motor and ...
Bisphenol-F and Bisphenol-S (BPF and BPS) Impair the Stemness of Neural Stem Cells and Neuronal Fate Decision in the Hippocampus Leading to Cognitive Dysfunctions
Bisphenol-F and Bisphenol-S (BPF and BPS) Impair the Stemness of Neural Stem Cells and Neuronal Fate Decision in the Hippocampus Leading to Cognitive Dysfunctions
Neurogenesis occurs throughout life in the hippocampus of the brain, and many environmental toxicants inhibit neural stem ...
Correction to: Possible Role of Raf-1 Kinase in the Development of Cerebral Vasospasm and Early Brain Injury After Experimental Subarachnoid Hemorrhage in Rats
Correction to: Possible Role of Raf-1 Kinase in the Development of Cerebral Vasospasm and Early Brain Injury After Experimental Subarachnoid Hemorrhage in Rats
Cite this articleZhang, J., Xu, X., Zhou, D. et al. Correction to: Possible Role of Raf-1 Kinase in the Development of Cer...
Brain Immune Cell Infiltration and Serum Metabolomic Characteristics Reveal that Lauric Acid Promotes Immune Cell Infiltration in Brain and Streptococcus suis Meningitis in Mice
Brain Immune Cell Infiltration and Serum Metabolomic Characteristics Reveal that Lauric Acid Promotes Immune Cell Infiltration in Brain and Streptococcus suis Meningitis in Mice
Although naturally Streptococcus suis serotype 2 (SS2) causes meningitis resulting in death or sequela of neurological sym...
Transactivator of Transcription (Tat)-Induced Neuroinflammation as a Key Pathway in Neuronal Dysfunction: A Scoping Review
Transactivator of Transcription (Tat)-Induced Neuroinflammation as a Key Pathway in Neuronal Dysfunction: A Scoping Review
The activity of HIV-1 and its viral proteins within the central nervous system (CNS) is responsible for a wide array of ne...
A Multistep In Silico Approach Identifies Potential Glioblastoma Drug Candidates via Inclusive Molecular Targeting of Glioblastoma Stem Cells
A Multistep In Silico Approach Identifies Potential Glioblastoma Drug Candidates via Inclusive Molecular Targeting of Glioblastoma Stem Cells
Glioblastoma (GBM) is the highest grade of glioma for which no effective therapy is currently available. Despite extensive...
Intrinsic ecto-5'-Nucleotidase/A1R Coupling may Confer Neuroprotection to the Cerebellum in Experimental Autoimmune Encephalomyelitis
Intrinsic ecto-5'-Nucleotidase/A1R Coupling may Confer Neuroprotection to the Cerebellum in Experimental Autoimmune Encephalomyelitis
Experimental autoimmune encephalomyelitis (EAE) is widely used animal model of multiple sclerosis (MS). The disease is cha...
Correction: Desmoglein-2 Affects Vascular Function in Moyamoya Disease by Interacting with MMP-9 and Influencing PI3K Signaling
Correction: Desmoglein-2 Affects Vascular Function in Moyamoya Disease by Interacting with MMP-9 and Influencing PI3K Signaling
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Imaging Findings and Toxicological Mechanisms of Nervous System Injury Caused by Diquat
Imaging Findings and Toxicological Mechanisms of Nervous System Injury Caused by Diquat
Diquat (DQ) is a nonselective bipyridine herbicide with a structure resembling paraquat (PQ). In recent years, the utiliza...
The Impact of Prevotella on Neurobiology in Aging: Deciphering Dendritic Cell Activity and Inflammatory Dynamics
The Impact of Prevotella on Neurobiology in Aging: Deciphering Dendritic Cell Activity and Inflammatory Dynamics
Prevotella species, notably Prevotella copri, significantly populate the human gut. In particular, P. copri is prevalent a...
Blood vessel organoids generated by base editing and harboring single nucleotide variation in Notch3 effectively recapitulate CADASIL-related pathogenesis
Blood vessel organoids generated by base editing and harboring single nucleotide variation in Notch3 effectively recapitulate CADASIL-related pathogenesis
Human blood vessel organoids (hBVOs) offer a promising platform for investigating vascular diseases and identifying therap...
Based on Virtual Screening and Simulation Exploring the Mechanism of Plant-Derived Compounds with PINK1 to Postherpetic Neuralgia
Based on Virtual Screening and Simulation Exploring the Mechanism of Plant-Derived Compounds with PINK1 to Postherpetic Neuralgia
Accumulating evidence strongly supports that PINK1 mutation can mediate mitochondrial autophagy dysfunction in dopaminergi...
Mirror-Image Pain Update: Complex Interactions Between Central and Peripheral Mechanisms
Mirror-Image Pain Update: Complex Interactions Between Central and Peripheral Mechanisms
The appearance of contralateral effects after unilateral injury has been shown in various experimental pain models, as wel...
Investigating the Effects of Perampanel on Autophagy-mediated Regulation of GluA2 and PSD95 in Epilepsy
Investigating the Effects of Perampanel on Autophagy-mediated Regulation of GluA2 and PSD95 in Epilepsy
Epilepsy is a chronic neurological disorder characterized by recurrent seizures. Despite various treatment approaches, a s...
Mesenchymal Stem Cell-Derived Extracellular Vesicles Alleviate Brain Damage Following Subarachnoid Hemorrhage via the Interaction of miR-140-5p and HDAC7
Mesenchymal Stem Cell-Derived Extracellular Vesicles Alleviate Brain Damage Following Subarachnoid Hemorrhage via the Interaction of miR-140-5p and HDAC7
Subarachnoid hemorrhage (SAH) triggers severe neuroinflammation and cognitive impairment, where microglial M1 polarization...
Limb-Clasping Response in NMDA Receptor Palmitoylation-Deficient Mice
Limb-Clasping Response in NMDA Receptor Palmitoylation-Deficient Mice
Proper regulation of N-methyl-d-aspartate-type glutamate receptor (NMDA receptor) expression is responsible for excitatory...
Correction to: Protective Effect of GM1 Attenuates Hippocampus and Cortex Apoptosis After Ketamine Exposure in Neonatal Rat via PI3K/AKT/GSK3β Pathway
Correction to: Protective Effect of GM1 Attenuates Hippocampus and Cortex Apoptosis After Ketamine Exposure in Neonatal Rat via PI3K/AKT/GSK3β Pathway
Correction to: Mol Neurobiol (2021) 58: 3471-3483Recently, we found there was technic...
Overexpression of α-Klotho isoforms promotes distinct Effects on BDNF-Induced Alterations in Dendritic Morphology
Overexpression of α-Klotho isoforms promotes distinct Effects on BDNF-Induced Alterations in Dendritic Morphology
α-Klotho (α-Kl) is a modulator of aging, neuroprotection, and cognition. Transcription of the Klotho gene produc...
HAT and HDAC: Enzyme with Contradictory Action in Neurodegenerative Diseases
HAT and HDAC: Enzyme with Contradictory Action in Neurodegenerative Diseases
In view of the increasing risk of neurodegenerative diseases, epigenetics plays a fundamental role in the field of neurosc...
The Interaction Between Nutraceuticals and Gut Microbiota: a Novel Therapeutic Approach to Prevent and Treatment Parkinson’s Disease
The Interaction Between Nutraceuticals and Gut Microbiota: a Novel Therapeutic Approach to Prevent and Treatment Parkinson’s Disease
Parkinson’s disease (PD) is a complex neurodegenerative disorder characterized by the progressive loss of dopaminerg...
Vilazodone Alleviates Neurogenesis-Induced Anxiety in the Chronic Unpredictable Mild Stress Female Rat Model: Role of Wnt/β-Catenin Signaling
Vilazodone Alleviates Neurogenesis-Induced Anxiety in the Chronic Unpredictable Mild Stress Female Rat Model: Role of Wnt/β-Catenin Signaling
Defective β-catenin signaling is accompanied with compensatory neurogenesis process that may pave to anxiety. β-...
Unraveling Dysregulated Cell Signaling Pathways, Genetic and Epigenetic Mysteries of Parkinson’s Disease
Unraveling Dysregulated Cell Signaling Pathways, Genetic and Epigenetic Mysteries of Parkinson’s Disease
Parkinson's disease (PD) is a prevalent and burdensome neurodegenerative disorder that has been extensively researched...
Astaxanthin and DHA Supplementation Modulates the Maternal Undernutrition-induced Impairment of Cognitive Behavior and Synaptic Plasticity in Adult Life of Offspring’s -Exploring the Molecular Mechanism
Astaxanthin and DHA Supplementation Modulates the Maternal Undernutrition-induced Impairment of Cognitive Behavior and Synaptic Plasticity in Adult Life of Offspring’s -Exploring the Molecular Mechanism
Maternal nutrition was recognized as a significant part of brain growth and maturation in most mammalian species. Timely i...
Transcriptomics of Human Brain Tissue in Parkinson’s Disease: a Comparison of Bulk and Single-cell RNA Sequencing
Transcriptomics of Human Brain Tissue in Parkinson’s Disease: a Comparison of Bulk and Single-cell RNA Sequencing
Parkinson’s disease (PD) is a chronic and progressive neurodegenerative disease leading to motor dysfunction and, in...
Are Advanced Oxidation Protein Products (AOPPs) Levels Altered in Neuropsychiatric Disorders? An Integrative Review
Are Advanced Oxidation Protein Products (AOPPs) Levels Altered in Neuropsychiatric Disorders? An Integrative Review
Neuropsychiatric disorders such as major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SZ) are cons...
MST2 Acts via AKT Activity to Promote Neurite Outgrowth and Functional Recovery after Spinal Cord Injury in Mice
MST2 Acts via AKT Activity to Promote Neurite Outgrowth and Functional Recovery after Spinal Cord Injury in Mice
Spinal cord injury (SCI) constitutes a significant clinical challenge, and there is extensive research focused on identify...
Mitophagy Upregulation Occurs Early in the Neurodegenerative Process Mediated by α-Synuclein
Mitophagy Upregulation Occurs Early in the Neurodegenerative Process Mediated by α-Synuclein
Parkinson’s disease (PD) is a progressive neurogenerative movement disorder characterized by dopaminergic cell death...
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