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Levomilnacipran Improves Lipopolysaccharide-Induced Dysregulation of Synaptic Plasticity and Depression-Like Behaviors via Activating BDNF/TrkB Mediated PI3K/Akt/mTOR Signaling Pathway
Levomilnacipran Improves Lipopolysaccharide-Induced Dysregulation of Synaptic Plasticity and Depression-Like Behaviors via Activating BDNF/TrkB Mediated PI3K/Akt/mTOR Signaling Pathway
Depression is a common psychological disease with high morbidity and mortality. Recently, the involvement of synaptic plas...
Laminar Distribution of Cannabinoid Receptor 1 in the Prefrontal Cortex of Nonhuman Primates
Laminar Distribution of Cannabinoid Receptor 1 in the Prefrontal Cortex of Nonhuman Primates
Cannabis is an annual herb of the genus Cannabis, with a history of medical use going back thousands of years. However, it...
Understanding Glycogen Synthase Kinase-3: A Novel Avenue for Alzheimer’s Disease
Understanding Glycogen Synthase Kinase-3: A Novel Avenue for Alzheimer’s Disease
Alzheimer’s Disease (AD) is the most prevalent form of age-related dementia. Even though a century has passed since ...
Association of Biochemical Parameters and Screening for Mutations in the MCU Gene in Alzheimer’s Disease Patients
Association of Biochemical Parameters and Screening for Mutations in the MCU Gene in Alzheimer’s Disease Patients
The most prevalent form of dementia, Alzheimer’s disease (AD) is a chronic illness that is on the rise among the ger...
Oligodeoxynucleotide IMT504: Effects on Central Nervous System Repair Following Demyelination
Oligodeoxynucleotide IMT504: Effects on Central Nervous System Repair Following Demyelination
Multiple sclerosis (MS) is an immune-mediated central nervous system (CNS) disease characterized by demyelination resultin...
Nano-Mediated Molecular Targeting in Diagnosis and Mitigation of Wilson Disease
Nano-Mediated Molecular Targeting in Diagnosis and Mitigation of Wilson Disease
Wilson disease, a rare genetic disorder resulting from mutations in the ATP7B gene disrupts copper metabolism, leading to ...
Posttreatment with PaPE-1 Protects from Aβ-Induced Neurodegeneration Through Inhibiting the Expression of Alzheimer’s Disease-Related Genes and Apoptosis Process That Involves Enhanced DNA Methylation of Specific Genes
Posttreatment with PaPE-1 Protects from Aβ-Induced Neurodegeneration Through Inhibiting the Expression of Alzheimer’s Disease-Related Genes and Apoptosis Process That Involves Enhanced DNA Methylation of Specific Genes
Targeting the non-nuclear estrogen receptor (ER) signaling has been postulated as novel therapeutic strategy for central n...
Targeted Therapy of Spinal Cord Injury: Inhibition of Apoptosis Is a Promising Therapeutic Strategy
Targeted Therapy of Spinal Cord Injury: Inhibition of Apoptosis Is a Promising Therapeutic Strategy
Spinal cord injury (SCI) is a serious disabling central nervous system injury that can lead to motor, sensory, and autonom...
Inhibiting Caveolin-1-Related Akt/mTOR Signaling Pathway Protects Against N-methyl-D-Aspartate Receptor Activation-Mediated Dysfunction of Blood–Brain Barrier in vitro
Inhibiting Caveolin-1-Related Akt/mTOR Signaling Pathway Protects Against N-methyl-D-Aspartate Receptor Activation-Mediated Dysfunction of Blood–Brain Barrier in vitro
The aim of this study was to further explore the role of caveolin-1 (Cav-1) related Akt/mTOR signaling pathway in blood br...
Effects of Intestinal M Cells on Intestinal Barrier and Neuropathological Properties in an AD Mouse Model
Effects of Intestinal M Cells on Intestinal Barrier and Neuropathological Properties in an AD Mouse Model
Intestinal microfold cells (M cells) play a critical role in the immune response of the intestinal mucosa by actively taki...
Deferoxamine Ameliorates Cypermethrin-Induced Iron Accumulation and Associated Alterations
Deferoxamine Ameliorates Cypermethrin-Induced Iron Accumulation and Associated Alterations
Iron is widely linked with the onset and development of Parkinson’s disease (PD). Accumulation of iron induces free ...
Integrative Metabolomics and Whole Transcriptome Sequencing Reveal Role for TREM2 in Metabolism Homeostasis in Alzheimer’s Disease
Integrative Metabolomics and Whole Transcriptome Sequencing Reveal Role for TREM2 in Metabolism Homeostasis in Alzheimer’s Disease
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia worldwide...
CircTrim37 Ameliorates Intracerebral Hemorrhage Outcomes by Modulating Microglial Polarization via the miR-30c-5p/SOCS3 Axis
CircTrim37 Ameliorates Intracerebral Hemorrhage Outcomes by Modulating Microglial Polarization via the miR-30c-5p/SOCS3 Axis
Circular RNAs (circRNAs) have been progressively recognized as critical regulators in the pathology and pathophysiology of...
A Synthetic Steroid 5α-Androst-3β, 5, 6β-triol Alleviates Radiation-Induced Brain Injury in Mice via Inhibiting GBP5/NF-κB/NLRP3 Signal Axis
A Synthetic Steroid 5α-Androst-3β, 5, 6β-triol Alleviates Radiation-Induced Brain Injury in Mice via Inhibiting GBP5/NF-κB/NLRP3 Signal Axis
Radiotherapy for head and neck tumors can lead to a severe complication known as radiation-induced brain injury (RIBI). Ho...
Trehalose Promotes Clearance of Proteotoxic Aggregation of Neurodegenerative Disease-Associated Aberrant Proteins
Trehalose Promotes Clearance of Proteotoxic Aggregation of Neurodegenerative Disease-Associated Aberrant Proteins
Accumulation of misfolded proteins compromises overall cellular health and fitness. The failure to remove misfolded protei...
Role of Maternal Immune Factors in Neuroimmunology of Brain Development
Role of Maternal Immune Factors in Neuroimmunology of Brain Development
Inflammation during pregnancy may occur due to various factors. This condition, in which maternal immune system activation...
Advanced Immunolabeling Method for Optical Volumetric Imaging Reveals Dystrophic Neurites of Dopaminergic Neurons in Alzheimer’s Disease Mouse Brain
Advanced Immunolabeling Method for Optical Volumetric Imaging Reveals Dystrophic Neurites of Dopaminergic Neurons in Alzheimer’s Disease Mouse Brain
Optical brain clearing combined with immunolabeling is valuable for analyzing molecular tissue structures, including compl...
Microglia as a Game Changer in Epilepsy Comorbid Depression
Microglia as a Game Changer in Epilepsy Comorbid Depression
As one of the most common neurological diseases, epilepsy is often accompanied by psychiatric disorders. Depression is the...
Gestational Fisetin Exerts Neuroprotection by Regulating Mitochondria-Directed Canonical Wnt Signaling, BBB Integrity, and Apoptosis in Prenatal VPA-Induced Rodent Model of Autism
Gestational Fisetin Exerts Neuroprotection by Regulating Mitochondria-Directed Canonical Wnt Signaling, BBB Integrity, and Apoptosis in Prenatal VPA-Induced Rodent Model of Autism
Embryonic valproic acid (VPA) has been considered a potential risk factor for autism. Majority of studies indicated that t...
Association Study Between Kynurenine 3-Monooxygenase (KMO) Gene and Parkinson’s Disease Patients
Association Study Between Kynurenine 3-Monooxygenase (KMO) Gene and Parkinson’s Disease Patients
The influence of various risk factors such as aging, intricate cellular molecular processes, and lifestyle factors like sm...
The Role of Necroptosis in Cerebral Ischemic Stroke
The Role of Necroptosis in Cerebral Ischemic Stroke
Cerebral ischemia, also known as ischemic stroke, accounts for nearly 85% of all strokes and is the leading cause of disab...
Hemorrhagic Shock and Resuscitation Causes Excessive Dopaminergic Signaling in the mPFC and Cognitive Dysfunction
Hemorrhagic Shock and Resuscitation Causes Excessive Dopaminergic Signaling in the mPFC and Cognitive Dysfunction
Peri-operative hemorrhagic shock and resuscitation (HSR), a severe traumatic stress, is closely associated with post-opera...
Recent Advances and Therapeutic Implications of 2-Oxoglutarate-Dependent Dioxygenases in Ischemic Stroke
Recent Advances and Therapeutic Implications of 2-Oxoglutarate-Dependent Dioxygenases in Ischemic Stroke
Ischemic stroke is a common disease with a high disability rate and mortality, which brings heavy pressure on families and...
N6-Methyladenosine Methylation of mRNA in Cell Apoptosis
N6-Methyladenosine Methylation of mRNA in Cell Apoptosis
Apoptosis, a highly controlled homeostatic mechanism that eliminates single cells without destroying tissue function, occu...
CNS-Active p38α MAPK Inhibitors for the Management of Neuroinflammatory Diseases: Medicinal Chemical Properties and Therapeutic Capabilities
CNS-Active p38α MAPK Inhibitors for the Management of Neuroinflammatory Diseases: Medicinal Chemical Properties and Therapeutic Capabilities
During the last two decades, many p38α mitogen-activated protein kinase (p38α MAPK) inhibitors have been develop...
Correction: The States of Different 5-HT Receptors Located in the Dorsal Raphe Nucleus Are Crucial for Regulating the Awakening During General Anesthesia
Correction: The States of Different 5-HT Receptors Located in the Dorsal Raphe Nucleus Are Crucial for Regulating the Awakening During General Anesthesia
Department of Anesthesiology, The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, 310006, Hangzho...
Exercise Reshapes the Brain: Molecular, Cellular, and Structural Changes Associated with Cognitive Improvements
Exercise Reshapes the Brain: Molecular, Cellular, and Structural Changes Associated with Cognitive Improvements
Physical exercise is well known as a non-pharmacological and holistic therapy believed to prevent and mitigate numerous ne...
The States of Different 5-HT Receptors Located in the Dorsal Raphe Nucleus Are Crucial for Regulating the Awakening During General Anesthesia
The States of Different 5-HT Receptors Located in the Dorsal Raphe Nucleus Are Crucial for Regulating the Awakening During General Anesthesia
General anesthesia is widely used in various clinical practices due to its ability to cause loss of consciousness. However...
Reduced Expression of the Htr2a, Grin1, and Bdnf Genes and Cognitive Inflexibility in a Model of High Compulsive Rats
Reduced Expression of the Htr2a, Grin1, and Bdnf Genes and Cognitive Inflexibility in a Model of High Compulsive Rats
Compulsivity is a core symptom in different psychopathological disorders, characterized by excessive behaviors and behavio...
Amplifying the Heat Shock Response Ameliorates ALS and FTD Pathology in Mouse and Human Models
Amplifying the Heat Shock Response Ameliorates ALS and FTD Pathology in Mouse and Human Models
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are now known as parts of a disease spectrum with co...
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