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Selective Noradrenergic Activation of BDNF Translation by Mirtazapine
Selective Noradrenergic Activation of BDNF Translation by Mirtazapine
Antidepressants are known for their neurotrophic effects, particularly through the regulation of brain-derived neurotrophi...
NF-κB Signaling Pathway in Rheumatoid Arthritis: Mechanisms and Therapeutic Potential
NF-κB Signaling Pathway in Rheumatoid Arthritis: Mechanisms and Therapeutic Potential
Rheumatoid arthritis (RA) is an autoimmune chronic inflammatory disease that imposes a heavy economic burden on patients a...
GIV/Girdin Modulation of Microglial Activation in Ischemic Stroke: Impact of FTO-Mediated m6A Modification
GIV/Girdin Modulation of Microglial Activation in Ischemic Stroke: Impact of FTO-Mediated m6A Modification
Ischemic stroke (IS) is one of the most common causes of death in the world. The lack of effective pharmacological treatme...
NEFL Modulates NRN1-Mediated Mitochondrial Pathway to Promote Diacetylmorphine-Induced Neuronal Apoptosis
NEFL Modulates NRN1-Mediated Mitochondrial Pathway to Promote Diacetylmorphine-Induced Neuronal Apoptosis
Diacetylmorphine abuse is a major social problem that jeopardizes the world, and abuse can cause serious neurological diso...
The Role of Cardiolipin in Brain Bioenergetics, Neuroinflammation, and Neurodegeneration
The Role of Cardiolipin in Brain Bioenergetics, Neuroinflammation, and Neurodegeneration
Cardiolipin (CL) is an essential phospholipid that supports the functions of mitochondrial membrane transporters and oxida...
Identification and Validation of Oxidative Stress-Related Hub Genes in Parkinson’s Disease
Identification and Validation of Oxidative Stress-Related Hub Genes in Parkinson’s Disease
Accumulating evidence suggests that oxidative stress plays a crucial role in the pathogenesis of Parkinson’s disease...
Mechanism of N6-Methyladenosine Modification in the Pathogenesis of Depression
Mechanism of N6-Methyladenosine Modification in the Pathogenesis of Depression
N6-methyladenosine (m6A) is one of the most common post-transcriptional RNA modifications, which plays a critical role in ...
Lactylation and Ischemic Stroke: Research Progress and Potential Relationship
Lactylation and Ischemic Stroke: Research Progress and Potential Relationship
Ischemic stroke is caused by interrupted cerebral blood flow and is a leading cause of mortality and disability worldwide....
Deletion of the Transient Receptor Potential Melastatin 2 Gene Mitigates the 6-Hydroxydopamine-Induced Parkinson’s Disease–Like Pathology
Deletion of the Transient Receptor Potential Melastatin 2 Gene Mitigates the 6-Hydroxydopamine-Induced Parkinson’s Disease–Like Pathology
Pharmacological inhibition of the transient receptor potential melastatin 2 (TRPM2), an oxidative stress–activated c...
Functional Outcome Prediction of Acute Ischemic Stroke Based on the Oral and Gut Microbiota
Functional Outcome Prediction of Acute Ischemic Stroke Based on the Oral and Gut Microbiota
Although several studies have identified a distinct gut microbiota in individuals with acute ischemic stroke (AIS), there ...
Oxidative Stress-mediated Loss of Hippocampal Parvalbumin Interneurons Contributes to Memory Precision Decline After Acute Sleep Deprivation
Oxidative Stress-mediated Loss of Hippocampal Parvalbumin Interneurons Contributes to Memory Precision Decline After Acute Sleep Deprivation
Sleep is pivotal to memory consolidation, and sleep deprivation (SD) after learning can impede this process, leading to me...
Sodium Danshensu Inhibits Macrophage Inflammation in Atherosclerosis via the miR-200a-3p/MEKK3/NF-κB Signaling Pathway
Sodium Danshensu Inhibits Macrophage Inflammation in Atherosclerosis via the miR-200a-3p/MEKK3/NF-κB Signaling Pathway
Macrophages are fundamental cellular components of atherosclerotic plaques, and inhibition of macrophage inflammation can ...
Integration of Single-Cell and Spatial Transcriptomic Data Reveals Spatial Architecture and Potential Biomarkers in Alzheimer’s Disease
Integration of Single-Cell and Spatial Transcriptomic Data Reveals Spatial Architecture and Potential Biomarkers in Alzheimer’s Disease
Alzheimer’s disease (AD) is a complex neurodegenerative disorder characterized by the gradual loss of neurons and th...
Serum Mature and Precursor Brain-Derived Neurotrophic Factors and Their Association with Neurocognitive Function in ART-Naïve Adults Living with HIV in Sub-Saharan Africa
Serum Mature and Precursor Brain-Derived Neurotrophic Factors and Their Association with Neurocognitive Function in ART-Naïve Adults Living with HIV in Sub-Saharan Africa
This study investigates the association between serum mature brain-derived neurotrophic factor (mBDNF), its precursor proB...
The Impact of the Histone Deacetylase Inhibitor—Sodium Butyrate on Complement-Mediated Synapse Loss in a Rat Model of Neonatal Hypoxia–Ischemia
The Impact of the Histone Deacetylase Inhibitor—Sodium Butyrate on Complement-Mediated Synapse Loss in a Rat Model of Neonatal Hypoxia–Ischemia
Perinatal asphyxia is one of the most important causes of morbidity and mortality in newborns. One of the key pathogenic f...
Alpha‑Asarone Ameliorates Neuronal Injury After Ischemic Stroke and Hemorrhagic Transformation by Attenuating Blood–Brain Barrier Destruction, Promoting Neurogenesis, and Inhibiting Neuroinflammation
Alpha‑Asarone Ameliorates Neuronal Injury After Ischemic Stroke and Hemorrhagic Transformation by Attenuating Blood–Brain Barrier Destruction, Promoting Neurogenesis, and Inhibiting Neuroinflammation
Recombinant tissue-type plasminogen activator (rt-PA), the primary drug for acute ischemic stroke (IS), has a narrow thera...
Parkinson's Disease and the Microbiota-Gut-Brain Axis: Metabolites, Mechanisms, and Innovative Therapeutic Strategies Targeting the Gut Microbiota
Parkinson's Disease and the Microbiota-Gut-Brain Axis: Metabolites, Mechanisms, and Innovative Therapeutic Strategies Targeting the Gut Microbiota
The human gut microbiota is diverse and abundant and plays important roles in regulating health by participating in metabo...
Upregulation of C1QC as a Mediator of Blood–Brain Barrier Damage in Type 2 Diabetes Mellitus
Upregulation of C1QC as a Mediator of Blood–Brain Barrier Damage in Type 2 Diabetes Mellitus
The blood–brain barrier (BBB) is a neurovascular structure that safeguards the brain by inhibiting the passage of ha...
Microglia Sing the Prelude of Neuroinflammation-Associated Depression
Microglia Sing the Prelude of Neuroinflammation-Associated Depression
Major depressive disorder (MDD) is a psychiatric condition characterized by sadness and anhedonia and is closely linked to...
Early-Life Stress Influences the Transcriptional Activation of Alpha-2A Adrenergic Receptor and Associated Protein Kinase A Signaling Molecules in the Frontal Cortex of Rats
Early-Life Stress Influences the Transcriptional Activation of Alpha-2A Adrenergic Receptor and Associated Protein Kinase A Signaling Molecules in the Frontal Cortex of Rats
Early life is a highly sensitive period associated with profound changes in brain structure and function. Adverse experien...
Copper Mitigates Atrazine-Induced Neurotoxicity in Parkinson’s Disease Models
Copper Mitigates Atrazine-Induced Neurotoxicity in Parkinson’s Disease Models
Atrazine (ATR), one of the most prevalent herbicides used worldwide, has been associated with various environmental health...
Integrated Profiling Identifies Long-Term Molecular Consequences of Prenatal Dexamethasone Treatment in the Rat Brain—Potential Triggers of Depressive Phenotype and Cognitive Impairment
Integrated Profiling Identifies Long-Term Molecular Consequences of Prenatal Dexamethasone Treatment in the Rat Brain—Potential Triggers of Depressive Phenotype and Cognitive Impairment
Prenatal excess of glucocorticoids (GCs) is considered to be one of the highly impacting factors contributing to depressio...
Caffeic Acid Attenuates Neuronal Apoptosis, Oxidative Stress, and Memory Deficits via Antioxidant Properties in Aging Rats Induced by D-Galactose
Caffeic Acid Attenuates Neuronal Apoptosis, Oxidative Stress, and Memory Deficits via Antioxidant Properties in Aging Rats Induced by D-Galactose
Aging is a main factor related to cognitive deficits. D-Galactose (D-gal), a monosaccharide, increases oxidative stress le...
Molecular and Behavioral Neuroprotective Effects of Clavulanic Acid and Crocin in Haloperidol-Induced Tardive Dyskinesia in Rats
Molecular and Behavioral Neuroprotective Effects of Clavulanic Acid and Crocin in Haloperidol-Induced Tardive Dyskinesia in Rats
Clavulanic acid (ClvA), a beta-lactamase inhibitor, is being explored for its significant neuroprotective potential. The e...
Multi-Omics Approach Reveals Genes and Pathways Affected in Miller-Dieker Syndrome
Multi-Omics Approach Reveals Genes and Pathways Affected in Miller-Dieker Syndrome
Miller-Dieker syndrome (MDS) is a rare neurogenetic disorder resulting from a heterozygous deletion of 26 genes in the MDS...
Inter-alpha Inhibitor Proteins Modulate Microvascular Endothelial Components and Cytokines After Exposure to Hypoxia–Ischemia in Neonatal Rats
Inter-alpha Inhibitor Proteins Modulate Microvascular Endothelial Components and Cytokines After Exposure to Hypoxia–Ischemia in Neonatal Rats
Inter-alpha inhibitor proteins (IAIPs) are neuroprotective and attenuate lipopolysaccharide (LPS)-mediated blood–bra...
Ginger Extract Improves Cognitive Dysfunction via Modulation of Gut Microbiota-Derived Short-Chain Fatty Acids in D-Galactose/Ovariectomy-Induced Alzheimer-Like Disease
Ginger Extract Improves Cognitive Dysfunction via Modulation of Gut Microbiota-Derived Short-Chain Fatty Acids in D-Galactose/Ovariectomy-Induced Alzheimer-Like Disease
Alzheimer’s disease (AD) is the most common form of dementia with complex causes and limited treatment options. Rece...
Effect of L-Carnitine Level on the Risk of Neuromyelitis Optica Spectrum Disorders: A Two-Sample Mendelian Randomization Study
Effect of L-Carnitine Level on the Risk of Neuromyelitis Optica Spectrum Disorders: A Two-Sample Mendelian Randomization Study
Previous research has often focused on studying the CNS damage in neuromyelitis optica spectrum disorders (NMOSD), while t...
Alzheimer’s Disease-Derived Outer Membrane Vesicles Exacerbate Cognitive Dysfunction, Modulate the Gut Microbiome, and Increase Neuroinflammation and Amyloid-β Production
Alzheimer’s Disease-Derived Outer Membrane Vesicles Exacerbate Cognitive Dysfunction, Modulate the Gut Microbiome, and Increase Neuroinflammation and Amyloid-β Production
Although our understanding of the molecular biology of Alzheimer’s disease (AD) continues to improve, the etiology o...
Mutation Screening of ATXN1, ATXN2, and ATXN3 in Amyotrophic Lateral Sclerosis
Mutation Screening of ATXN1, ATXN2, and ATXN3 in Amyotrophic Lateral Sclerosis
Emerging evidence suggests potential disease modifying roles of ATXN1, ATXN2, and ATXN3 in amyotrophic lateral sclerosis (...
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