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Hormonal interventions in skin wounds – a mini review
Hormonal interventions in skin wounds – a mini review
The ability to heal from wounds is perhaps the most important biological function that ensures our survival and perpetuati...
Probiotic bacteria-released extracellular vesicles enhance macrophage phagocytosis in polymicrobial sepsis by activating the FPR1/2 pathway
Probiotic bacteria-released extracellular vesicles enhance macrophage phagocytosis in polymicrobial sepsis by activating the FPR1/2 pathway
Sepsis-induced organ failure and high mortality are largely ascribed to the failure of bacterial clearance from the infect...
Tetrandrine induces muscle atrophy involving ROS-mediated inhibition of Akt and FoxO3
Tetrandrine induces muscle atrophy involving ROS-mediated inhibition of Akt and FoxO3
Tetrandrine (Tet), a well-known drug of calcium channel blocker, has been broadly applied for anti-inflammatory and anti-f...
Cytokine modulation in pelvic organ prolapse and urinary incontinence: from molecular insights to therapeutic targets
Cytokine modulation in pelvic organ prolapse and urinary incontinence: from molecular insights to therapeutic targets
Pelvic organ prolapse (POP) and urinary incontinence (UI) are common disorders that significantly impact women’s qua...
FTO suppresses cardiac fibrosis after myocardial infarction via m6A-mediated epigenetic modification of EPRS
FTO suppresses cardiac fibrosis after myocardial infarction via m6A-mediated epigenetic modification of EPRS
Cardiac fibrosis is common in myocardial infarction (MI), leading to progressive cardiac dysfunction. Studies suggested th...
Correction: Occurrence and role of Tph cells in various renal diseases
Correction: Occurrence and role of Tph cells in various renal diseases
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Myc 9aaTAD activation domain binds to mediator of transcription with superior high affinity
Myc 9aaTAD activation domain binds to mediator of transcription with superior high affinity
The overexpression of MYC genes is frequently found in many human cancers, including adult and pediatric malignant brain t...
Machine learning-driven discovery of novel therapeutic targets in diabetic foot ulcers
Machine learning-driven discovery of novel therapeutic targets in diabetic foot ulcers
1. This is the first report identifying SCUBE1 and RNF103-CHMP3 as therapeutic targets for diabetic foot ulcers (DFU). 2. ...
The therapeutic potential of Apigenin in amyotrophic lateral sclerosis through ALDH1A2/Nrf2/ARE signaling
The therapeutic potential of Apigenin in amyotrophic lateral sclerosis through ALDH1A2/Nrf2/ARE signaling
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by motor neuron loss leading ...
Oral administration of butylated hydroxytoluene induces neuroprotection in a streptozotocin-induced rat Alzheimer’s disease model via inhibition of neuronal ferroptosis
Oral administration of butylated hydroxytoluene induces neuroprotection in a streptozotocin-induced rat Alzheimer’s disease model via inhibition of neuronal ferroptosis
Alzheimer’s disease (AD) is the most common human neurodegenerative disorder worldwide. Owing to its chronic nature,...
USP15 regulates radiation-induced DNA damage and intestinal injury through K48-linked deubiquitination and stabilisation of ATM
USP15 regulates radiation-induced DNA damage and intestinal injury through K48-linked deubiquitination and stabilisation of ATM
Radiation-induced intestinal injury (RIII) interrupts the scheduled processes of abdominal and pelvic radiotherapy (RT) an...
Dexmedetomidine alleviates intestinal ischemia/reperfusion injury by modulating intestinal neuron autophagy and mitochondrial homeostasis via Nupr1 regulation
Dexmedetomidine alleviates intestinal ischemia/reperfusion injury by modulating intestinal neuron autophagy and mitochondrial homeostasis via Nupr1 regulation
Intestinal ischemia/reperfusion injury (I/R) is a common yet challenging-to-treat condition, presenting a significant clin...
Single cell RNA-seq reveals cellular and transcriptional heterogeneity in the splenic CD11b+Ly6Chigh monocyte population expanded in sepsis-surviving mice
Single cell RNA-seq reveals cellular and transcriptional heterogeneity in the splenic CD11b+Ly6Chigh monocyte population expanded in sepsis-surviving mice
Sepsis survivors exhibit immune dysregulation that contributes to poor long-term outcomes. Phenotypic and functional alter...
Extracellular vesicles from microglial cells activated by abnormal heparan sulfate oligosaccharides from Sanfilippo patients impair neuronal dendritic arborization
Extracellular vesicles from microglial cells activated by abnormal heparan sulfate oligosaccharides from Sanfilippo patients impair neuronal dendritic arborization
In mucopolysaccharidosis type III (MPS III, also known as Sanfilippo syndrome), a pediatric neurodegenerative disorder, ac...
N6-methyladenosine and its epitranscriptomic effects on hematopoietic stem cell regulation and leukemogenesis
N6-methyladenosine and its epitranscriptomic effects on hematopoietic stem cell regulation and leukemogenesis
N6-methyladenosine (m6A) RNA modification orchestrates cellular epitranscriptome through tuning the homeostasis of transcr...
Increased levels of versican and insulin-like growth factor 1 in peritumoral mammary adipose tissue are related to aggressiveness in estrogen receptor-positive breast cancer
Increased levels of versican and insulin-like growth factor 1 in peritumoral mammary adipose tissue are related to aggressiveness in estrogen receptor-positive breast cancer
The adipose tissue (AT) surrounding breast cancer (BC) plays a pivotal role in cancer progression and represents an optima...
MGST1 facilitates novel KRASG12D inhibitor resistance in KRASG12D-mutated pancreatic ductal adenocarcinoma by inhibiting ferroptosis
MGST1 facilitates novel KRASG12D inhibitor resistance in KRASG12D-mutated pancreatic ductal adenocarcinoma by inhibiting ferroptosis
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer with a low 5-year survival rate. Treatment options for P...
Deciphering the role of host-gut microbiota crosstalk via diverse sources of extracellular vesicles in colorectal cancer
Deciphering the role of host-gut microbiota crosstalk via diverse sources of extracellular vesicles in colorectal cancer
Colorectal cancer is the most common type of cancer in the digestive system and poses a major threat to human health. The ...
Dihydroberberine alleviates Th17/Treg imbalance in premature ovarian insufficiency mice via inhibiting Rheb/mTOR signaling
Dihydroberberine alleviates Th17/Treg imbalance in premature ovarian insufficiency mice via inhibiting Rheb/mTOR signaling
Premature ovarian insufficiency (POI) is an immune-related condition. Dihydroberberine (dhBBR) plays a regulatory role in ...
Endometriosis development in relation to hypoxia: a murine model study
Endometriosis development in relation to hypoxia: a murine model study
Endometriosis, due to its ambiguous symptoms, still remains one of the most difficult female diseases to treat, with an av...
Wnt/β-catenin signaling pathway: proteins' roles in osteoporosis and cancer diseases and the regulatory effects of natural compounds on osteoporosis
Wnt/β-catenin signaling pathway: proteins' roles in osteoporosis and cancer diseases and the regulatory effects of natural compounds on osteoporosis
Osteoblasts are mainly derived from mesenchymal stem cells in the bone marrow. These stem cells can differentiate into ost...
Deciphering STAT3’s negative regulation of LHPP in ESCC progression through single-cell transcriptomics analysis
Deciphering STAT3’s negative regulation of LHPP in ESCC progression through single-cell transcriptomics analysis
Esophageal Squamous Cell Carcinoma (ESCC) remains a predominant health concern in the world, characterized by high prevale...
MECOM and the PRDM gene family in uterine endometrial cancer: bioinformatics and experimental insights into pathogenesis and therapeutic potentials
MECOM and the PRDM gene family in uterine endometrial cancer: bioinformatics and experimental insights into pathogenesis and therapeutic potentials
To elucidate the expression profiles, methylation states, and clinicopathological significance of the PRDM gene family, fo...
Skeletal myotubes expressing ALS mutant SOD1 induce pathogenic changes, impair mitochondrial axonal transport, and trigger motoneuron death
Skeletal myotubes expressing ALS mutant SOD1 induce pathogenic changes, impair mitochondrial axonal transport, and trigger motoneuron death
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the loss of motoneurons (MNs), a...
Assessing personalized molecular portraits underlying endothelial-to-mesenchymal transition within pulmonary arterial hypertension
Assessing personalized molecular portraits underlying endothelial-to-mesenchymal transition within pulmonary arterial hypertension
Pulmonary arterial hypertension (PAH) is a progressive and rapidly fatal disease with an intricate etiology. Identifying b...
CHRDL1 inhibits OSCC metastasis via MAPK signaling-mediated inhibition of MED29
CHRDL1 inhibits OSCC metastasis via MAPK signaling-mediated inhibition of MED29
CHRDL1 belongs to a novel class of mRNA molecules. Nonetheless, the specific biological functions and underlying mechanism...
Mechanistic role of mesencephalic astrocyte-derived neurotrophic factor in myocardial ischemia/reperfusion injury
Mechanistic role of mesencephalic astrocyte-derived neurotrophic factor in myocardial ischemia/reperfusion injury
Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a protein crucial for cellular stress response and survival,...
Exosomes derived from apical papilla stem cells improve NASH by regulating fatty acid metabolism and reducing inflammation
Exosomes derived from apical papilla stem cells improve NASH by regulating fatty acid metabolism and reducing inflammation
Apical papilla stem cells (SCAPs) exhibit significant potential for tissue repair, characterized by their anti-inflammator...
Oral supplementation of choline attenuates the development of alcohol-related liver disease (ALD)
Oral supplementation of choline attenuates the development of alcohol-related liver disease (ALD)
Chronic alcohol intake is associated with alterations of choline metabolism in various tissues. Here, we assessed if an or...
Prostate cancer cell-derived exosomes ZNF667-AS1 reduces TGFBR1 mRNA stability to inhibit Treg expansion and DTX resistance by binding to U2AF1
Prostate cancer cell-derived exosomes ZNF667-AS1 reduces TGFBR1 mRNA stability to inhibit Treg expansion and DTX resistance by binding to U2AF1
Docetaxel (DTX) resistance attenuates anti-tumor effects of DTX on prostate cancer (mCRPC) and drug resistance was related...
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