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Sodium butyrate regulates macrophage polarization by TGR5/β-arrestin2 in vitro
Sodium butyrate regulates macrophage polarization by TGR5/β-arrestin2 in vitro
Macrophages play an important role in the pathogenesis of ulcerative colitis (UC). We will explore the effects of sodium b...
Dioscin pretreatment ameliorates ferroptosis in cardiomyocytes after myocardial infarction via inhibiting endoplasmic reticulum stress
Dioscin pretreatment ameliorates ferroptosis in cardiomyocytes after myocardial infarction via inhibiting endoplasmic reticulum stress
Myocardial infarction (MI) remains a leading cause of mortality globally, often resulting in irreversible damage to cardio...
Tegaserod maleate exerts anti-tumor effects on prostate cancer via repressing sonic hedgehog signaling pathway
Tegaserod maleate exerts anti-tumor effects on prostate cancer via repressing sonic hedgehog signaling pathway
Prostate cancer (PCa) is a highly common type of malignancy and affects millions of men in the world since it is easy to r...
Defective Slc7a7 transport reduces erythropoietin compromising erythropoiesis
Defective Slc7a7 transport reduces erythropoietin compromising erythropoiesis
Lysinuric protein intolerance is a rare autosomal disorder caused by mutations in the Slc7a7 gene that lead to impaired tr...
Myricetin exposure reduces PC differentiation in vitro in primary human B cells
Myricetin exposure reduces PC differentiation in vitro in primary human B cells
The process of B cell activation and plasma cell (PC) formation involves morphological, transcriptional, and metabolic cha...
Nobiletin restores the intestinal barrier of HFD-induced obese mice by promoting MHC-II expression and lipid metabolism
Nobiletin restores the intestinal barrier of HFD-induced obese mice by promoting MHC-II expression and lipid metabolism
The incidence of obesity is increasing annually worldwide. A high-fat diet (HFD) causes intestinal barrier damage, but eff...
Formononetin ameliorates polycystic ovary syndrome through suppressing NLRP3 inflammasome
Formononetin ameliorates polycystic ovary syndrome through suppressing NLRP3 inflammasome
Polycystic ovary syndrome (PCOS) is a common gynecological disease accompanied by multiple clinical features, including an...
Accumulation of advanced oxidative protein products exacerbate satellite glial cells activation and neuropathic pain
Accumulation of advanced oxidative protein products exacerbate satellite glial cells activation and neuropathic pain
Neuropathic pain (NP) is a debilitating condition caused by lesion or dysfunction in the somatosensory nervous system. Acc...
Disrupting of IGF2BP3-stabilized CLDN11 mRNA by TNF-α increases intestinal permeability in obesity-related severe acute pancreatitis
Disrupting of IGF2BP3-stabilized CLDN11 mRNA by TNF-α increases intestinal permeability in obesity-related severe acute pancreatitis
Obesity is a significant risk factor for severe acute pancreatitis (SAP) and is typically associated with increased intest...
Purine-rich element binding protein alpha: a DNA/RNA binding protein with multiple roles in cancers
Purine-rich element binding protein alpha: a DNA/RNA binding protein with multiple roles in cancers
Proteins that bind to DNA/RNA are typically evolutionarily conserved with multiple regulatory functions in transcription i...
Tousled-like kinase loss confers PARP inhibitor resistance in BRCA1-mutated cancers by impeding non-homologous end joining repair
Tousled-like kinase loss confers PARP inhibitor resistance in BRCA1-mutated cancers by impeding non-homologous end joining repair
Double-strand breaks (DSBs) are primarily repaired through non-homologous end joining (NHEJ) and homologous recombination ...
FPR1 affects acute rejection in kidney transplantation by regulating iron metabolism in neutrophils
FPR1 affects acute rejection in kidney transplantation by regulating iron metabolism in neutrophils
Acute rejection (AR) is one of the significant factors contributing to poor prognosis in patients following kidney transpl...
AdipoR1 enhances the radiation resistance via ESR1/CCNB1IP1/cyclin B1 pathway in hepatocellular carcinoma cells
AdipoR1 enhances the radiation resistance via ESR1/CCNB1IP1/cyclin B1 pathway in hepatocellular carcinoma cells
Hepatocellular carcinoma is one of the most common malignant tumors, and radiotherapy plays a pivotal role in its therapeu...
Chronic inflammation in post-acute sequelae of COVID-19 modulates gut microbiome: a review of literature on COVID-19 sequelae and gut dysbiosis
Chronic inflammation in post-acute sequelae of COVID-19 modulates gut microbiome: a review of literature on COVID-19 sequelae and gut dysbiosis
Long COVID or Post-acute sequelae of COVID-19 is an emerging syndrome, recognized in COVID-19 patients who suffer from mil...
Endocrine and metabolic alterations in response to systemic inflammation and sepsis: a review article
Endocrine and metabolic alterations in response to systemic inflammation and sepsis: a review article
Severe sepsis is cognate with life threatening multi-organ dysfunction. There is a disturbance in endocrine functions with...
D-mannose promotes diabetic wound healing through inhibiting advanced glycation end products formation in keratinocytes
D-mannose promotes diabetic wound healing through inhibiting advanced glycation end products formation in keratinocytes
Diabetic chronic foot ulcers pose a significant therapeutic challenge around the world, resulting in adverse effects and c...
Microbially produced imidazole propionate impairs prostate cancer progression through PDZK1
Microbially produced imidazole propionate impairs prostate cancer progression through PDZK1
A close relationship exists between castration-resistant prostate cancer (CRPC) and histidine metabolism by gut microbes. ...
Nootkatone inhibits the progression of glioblastoma by activating the ATF4-CHOP-CHAC1 pathway
Nootkatone inhibits the progression of glioblastoma by activating the ATF4-CHOP-CHAC1 pathway
Glioblastoma multiforme (GBM) represents a primary brain tumor that is widely prevalent, and clinical drugs available for ...
The systemic evolutionary theory of the origin of cancer (SETOC): an update
The systemic evolutionary theory of the origin of cancer (SETOC): an update
The Systemic Evolutionary Theory of the Origin of Cancer (SETOC) is a recently proposed theory founded on two primary prin...
The role and mechanism of HMGB1-mediated Notch1/Hes-1 pathway in anxiety and depression-like behaviors in mice with chronic rhinosinusitis
The role and mechanism of HMGB1-mediated Notch1/Hes-1 pathway in anxiety and depression-like behaviors in mice with chronic rhinosinusitis
Chronic rhinosinusitis (CRS) is a global health issue, with some patients experiencing anxiety and depression-like symptom...
An eCIRP inhibitor attenuates fibrosis and ferroptosis in ischemia and reperfusion induced chronic kidney disease
An eCIRP inhibitor attenuates fibrosis and ferroptosis in ischemia and reperfusion induced chronic kidney disease
Chronic kidney disease (CKD) is a leading cause of death in the United States, and renal fibrosis represents a pathologic ...
AM1241 inhibits chondrocyte inflammation and ECM degradation through the Nrf2/HO-1 and NF-κB pathways and alleviates osteoarthritis in mice
AM1241 inhibits chondrocyte inflammation and ECM degradation through the Nrf2/HO-1 and NF-κB pathways and alleviates osteoarthritis in mice
This study aimed to investigate the impact of AM1241 on lipopolysaccharide (LPS)-induced chondrocyte inflammation in mice ...
Decreased expression of LEF1 caused defective decidualization by inhibiting IL-11 expression in patients with adenomyosis
Decreased expression of LEF1 caused defective decidualization by inhibiting IL-11 expression in patients with adenomyosis
Reduced lymphoid enhancer-binding factor 1 (LEF1) expression in patients with adenomyosis during the mid-secretory phase l...
Ubiquitin specific peptidase 11 knockdown slows Huntington’s disease progression via regulating mitochondrial dysfunction and neuronal damage depending on PTEN-mediated AKT pathway
Ubiquitin specific peptidase 11 knockdown slows Huntington’s disease progression via regulating mitochondrial dysfunction and neuronal damage depending on PTEN-mediated AKT pathway
Mitochondrial dysfunction and neuronal damage are major sign of cytopathology in Huntington’s disease (HD), a neurod...
Multi‑omics identification of a novel signature for serous ovarian carcinoma in the context of 3P medicine and based on twelve programmed cell death patterns: a multi-cohort machine learning study
Multi‑omics identification of a novel signature for serous ovarian carcinoma in the context of 3P medicine and based on twelve programmed cell death patterns: a multi-cohort machine learning study
Predictive, preventive, and personalized medicine (PPPM/3PM) is a strategy aimed at improving the prognosis of cancer, and...
NEK8 promotes the progression of gastric cancer by reprogramming asparagine metabolism
NEK8 promotes the progression of gastric cancer by reprogramming asparagine metabolism
Several members of the NIMA-related kinase (NEK) family have been implicated in tumor progression; however, the role and u...
Differential expression of plasma proteins and pathway enrichments in pediatric diabetic ketoacidosis
Differential expression of plasma proteins and pathway enrichments in pediatric diabetic ketoacidosis
In children with type 1 diabetes (T1D), diabetic ketoacidosis (DKA) triggers a significant inflammatory response; however,...
Advancing therapeutic strategies for graft-versus-host disease by targeting gut microbiome dynamics in allogeneic hematopoietic stem cell transplantation: current evidence and future directions
Advancing therapeutic strategies for graft-versus-host disease by targeting gut microbiome dynamics in allogeneic hematopoietic stem cell transplantation: current evidence and future directions
Hematopoietic stem cell transplantation (HSCT) is a highly effective therapy for malignant blood illnesses that pose a hig...
Hyperoxia-activated Nrf2 regulates ferroptosis in intestinal epithelial cells and intervenes in inflammatory reaction through COX-2/PGE2/EP2 pathway
Hyperoxia-activated Nrf2 regulates ferroptosis in intestinal epithelial cells and intervenes in inflammatory reaction through COX-2/PGE2/EP2 pathway
The lack of knowledge about the mechanism of hyperoxia-induced intestinal injury has attracted considerable attention, due...
Thioredoxin-interacting protein (TXNIP) inhibition promotes retinal ganglion cell survival and facilitates M1-like microglial transformation via the PI3K/Akt pathway in glaucoma
Thioredoxin-interacting protein (TXNIP) inhibition promotes retinal ganglion cell survival and facilitates M1-like microglial transformation via the PI3K/Akt pathway in glaucoma
Glaucoma is a group of heterogeneous neurodegenerative diseases with abnormal energy metabolism and imbalanced neuroinflam...
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