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ECHDC2 inhibits the proliferation of gastric cancer cells by binding with NEDD4 to degrade MCCC2 and reduce aerobic glycolysis
ECHDC2 inhibits the proliferation of gastric cancer cells by binding with NEDD4 to degrade MCCC2 and reduce aerobic glycolysis
The Enoyl-CoA hydratase/isomerase family plays a crucial role in the metabolism of tumors, being crucial for maintaining t...
Bortezomib restrains M2 polarization and reduces CXCL16-associated CXCR6+CD4 T cell chemotaxis in bleomycin-induced pulmonary fibrosis
Bortezomib restrains M2 polarization and reduces CXCL16-associated CXCR6+CD4 T cell chemotaxis in bleomycin-induced pulmonary fibrosis
The development of pulmonary fibrosis involves a cascade of events, in which inflammation mediated by immune cells plays a...
Effect of antibody-mediated connective tissue growth factor neutralization on lung edema in ventilator-induced lung injury in rats
Effect of antibody-mediated connective tissue growth factor neutralization on lung edema in ventilator-induced lung injury in rats
Acute respiratory distress syndrome (ARDS) is characterized by alveolar edema that can progress to septal fibrosis. Mechan...
Extracellular matrix marker LAMC2 targets ZEB1 to promote TNBC malignancy via up-regulating CD44/STAT3 signaling pathway
Extracellular matrix marker LAMC2 targets ZEB1 to promote TNBC malignancy via up-regulating CD44/STAT3 signaling pathway
Triple negative breast cancer (TNBC) is a heterogeneous and aggressive disease characterized by a high risk of mortality a...
BRD4 promotes gouty arthritis through MDM2-mediated PPARγ degradation and pyroptosis
BRD4 promotes gouty arthritis through MDM2-mediated PPARγ degradation and pyroptosis
Gouty arthritis (GA) is characterized by monosodium urate (MSU) crystal accumulation that instigates NLRP3-mediated pyropt...
Dickkopf-1 (DKK1) blockade mitigates osteogenesis imperfecta (OI) related bone disease
Dickkopf-1 (DKK1) blockade mitigates osteogenesis imperfecta (OI) related bone disease
The current treatment of osteogenesis imperfecta (OI) is imperfect. Our study thus delves into the potential of using Dick...
IGF2BP3 promotes glutamine metabolism of endometriosis by interacting with UCA1 to enhances the mRNA stability of GLS1
IGF2BP3 promotes glutamine metabolism of endometriosis by interacting with UCA1 to enhances the mRNA stability of GLS1
Insulin like growth factor II mRNA binding protein 3 (IGF2BP3) has been implicated in numerous inflammatory and cancerous ...
Biological relevance of alternative splicing in hematologic malignancies
Biological relevance of alternative splicing in hematologic malignancies
Alternative splicing (AS) is a strictly regulated process that generates multiple mRNA variants from a single gene, thus c...
AMPK activation eliminates senescent cells in diabetic wound by inducing NCOA4 mediated ferritinophagy
AMPK activation eliminates senescent cells in diabetic wound by inducing NCOA4 mediated ferritinophagy
Diabetic wounds are one of the long-term complications of diabetes, with a disordered microenvironment, diabetic wounds ca...
The role of Interleukin-22 in severe acute pancreatitis
The role of Interleukin-22 in severe acute pancreatitis
Severe acute pancreatitis (SAP) begins with premature activation of enzymes, promoted by the immune system, triggering a p...
Bleomycin induces senescence and repression of DNA repair via downregulation of Rad51
Bleomycin induces senescence and repression of DNA repair via downregulation of Rad51
Bleomycin, a potent antitumor agent, is limited in clinical use due to the potential for fatal pulmonary toxicity. The acc...
CHMP5 attenuates osteoarthritis via inhibiting chondrocyte apoptosis and extracellular matrix degradation: involvement of NF-κB pathway
CHMP5 attenuates osteoarthritis via inhibiting chondrocyte apoptosis and extracellular matrix degradation: involvement of NF-κB pathway
Osteoarthritis (OA), the most common joint disease, is linked with chondrocyte apoptosis and extracellular matrix (ECM) de...
STK16 promoted colorectal cancer progress in a c-MYC signaling-dependent manner
STK16 promoted colorectal cancer progress in a c-MYC signaling-dependent manner
Colorectal cancer standed as a global health challenge, ranking third in cancer incidence and second in cancer-related dea...
The plasma proteome differentiates the multisystem inflammatory syndrome in children (MIS-C) from children with SARS-CoV-2 negative sepsis
The plasma proteome differentiates the multisystem inflammatory syndrome in children (MIS-C) from children with SARS-CoV-2 negative sepsis
The Multi-System Inflammatory Syndrome in Children (MIS-C) can develop several weeks after SARS-CoV-2 infection and requir...
F127-SE-tLAP thermosensitive hydrogel alleviates bleomycin-induced skin fibrosis via TGF-β/Smad pathway
F127-SE-tLAP thermosensitive hydrogel alleviates bleomycin-induced skin fibrosis via TGF-β/Smad pathway
Skin fibrosis affects the normal function of the skin. TGF-β1 is a key cytokine that affects organ fibrosis. The late...
Single-cell characterisation of tissue homing CD4 + and CD8 + T cell clones in immune-mediated refractory arthritis
Single-cell characterisation of tissue homing CD4 + and CD8 + T cell clones in immune-mediated refractory arthritis
Immune-mediated arthritis is a group of autoinflammatory diseases, where the patient’s own immune system attacks and...
SALL4 in gastrointestinal tract cancers: upstream and downstream regulatory mechanisms
SALL4 in gastrointestinal tract cancers: upstream and downstream regulatory mechanisms
Effective therapeutic targets and early diagnosis are major challenges in the treatment of gastrointestinal tract (GIT) ca...
Sirtuins in intervertebral disc degeneration: current understanding
Sirtuins in intervertebral disc degeneration: current understanding
Intervertebral disc degeneration (IVDD) is one of the etiologic factors of degenerative spinal diseases, which can lead to...
Omentin-1 inhibits the development of benign prostatic hyperplasia by attenuating local inflammation
Omentin-1 inhibits the development of benign prostatic hyperplasia by attenuating local inflammation
Benign prostatic hyperplasia (BPH) is a prevalent disease affecting elderly men, with chronic inflammation being a critica...
Endoplasmic reticulum stress and therapeutic strategies in metabolic, neurodegenerative diseases and cancer
Endoplasmic reticulum stress and therapeutic strategies in metabolic, neurodegenerative diseases and cancer
The accumulation of unfolded or misfolded proteins within the endoplasmic reticulum (ER), due to genetic determinants and ...
A Journey in Science: Molecular vaccines for global child health in troubled times of anti-science
A Journey in Science: Molecular vaccines for global child health in troubled times of anti-science
My scientific life in translational medicine runs in two parallel, yet often converging paths. The first, is four-decade-l...