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Receptor tyrosine kinase C-kit promotes a destructive phenotype of FLS in osteoarthritis via intracellular EMT signaling
Receptor tyrosine kinase C-kit promotes a destructive phenotype of FLS in osteoarthritis via intracellular EMT signaling
Chronic inflammation, mainly derived from fibroblast-like synoviocytes (FLSs), plays a central role in the pathomechanism ...
The promotion action of AURKA on post-ischemic angiogenesis in diabetes-related limb ischemia
The promotion action of AURKA on post-ischemic angiogenesis in diabetes-related limb ischemia
Diabetes-related limb ischemia is a challenge for lower extremity amputation. Aurora Kinase A (AURKA) is an essential seri...
Targeting CLDN6 in germ cell tumors by an antibody-drug-conjugate and studying therapy resistance of yolk-sac tumors to identify and screen specific therapeutic options
Targeting CLDN6 in germ cell tumors by an antibody-drug-conjugate and studying therapy resistance of yolk-sac tumors to identify and screen specific therapeutic options
Being the standard-of-care for four decades, cisplatin-based chemotherapy is highly efficient in treating germ cell tumors...
Single-cell transcriptome reveals Staphylococcus aureus modulating fibroblast differentiation in the bone-implant interface
Single-cell transcriptome reveals Staphylococcus aureus modulating fibroblast differentiation in the bone-implant interface
This study aimed to delineate the cell heterogeneity in the bone-implant interface and investigate the fibroblast response...
Use of machine learning-based integration to develop a monocyte differentiation-related signature for improving prognosis in patients with sepsis
Use of machine learning-based integration to develop a monocyte differentiation-related signature for improving prognosis in patients with sepsis
Although significant advances have been made in intensive care medicine and antibacterial treatment, sepsis is still a com...
Identification of kukoamine a as an anti-osteoporosis drug target using network pharmacology and experiment verification
Identification of kukoamine a as an anti-osteoporosis drug target using network pharmacology and experiment verification
Osteoporosis (OP) is a major and growing public health problem characterized by decreased bone mineral density and destroy...
The role of NEDD4 related HECT-type E3 ubiquitin ligases in defective autophagy in cancer cells: molecular mechanisms and therapeutic perspectives
The role of NEDD4 related HECT-type E3 ubiquitin ligases in defective autophagy in cancer cells: molecular mechanisms and therapeutic perspectives
The homologous to the E6-AP carboxyl terminus (HECT)-type E3 ubiquitin ligases are the selective executers in the protein ...
LncRNA GAS5 suppresses TGF-β1-induced transformation of pulmonary pericytes into myofibroblasts by recruiting KDM5B and promoting H3K4me2/3 demethylation of the PDGFRα/β promoter
LncRNA GAS5 suppresses TGF-β1-induced transformation of pulmonary pericytes into myofibroblasts by recruiting KDM5B and promoting H3K4me2/3 demethylation of the PDGFRα/β promoter
Idiopathic pulmonary fibrosis (IPF) is a condition that may cause persistent pulmonary damage. The transformation of peric...
Organ and cell-specific biomarkers of Long-COVID identified with targeted proteomics and machine learning
Organ and cell-specific biomarkers of Long-COVID identified with targeted proteomics and machine learning
Survivors of acute COVID-19 often suffer prolonged, diffuse symptoms post-infection, referred to as “Long-COVID̶...
Paediatric sepsis-associated encephalopathy (SAE): a comprehensive review
Paediatric sepsis-associated encephalopathy (SAE): a comprehensive review
Sepsis-associated encephalopathy (SAE) is one of the most common types of organ dysfunction without overt central nervous ...
Can endocan serve as a molecular “hepatostat” in liver regeneration?
Can endocan serve as a molecular “hepatostat” in liver regeneration?
Intriguingly, liver regeneration after injury does not induce uncontrolled growth and the underlying mechanisms of such a ...
Oxidative stress and epigenetics in ocular vascular aging: an updated review
Oxidative stress and epigenetics in ocular vascular aging: an updated review
Vascular aging is an inevitable process with advancing age, which plays a crucial role in the pathogenesis of cardiovascul...
BMP7 ameliorates intervertebral disc degeneration in type 1 diabetic rats by inhibiting pyroptosis of nucleus pulposus cells and NLRP3 inflammasome activity
BMP7 ameliorates intervertebral disc degeneration in type 1 diabetic rats by inhibiting pyroptosis of nucleus pulposus cells and NLRP3 inflammasome activity
Accumulating evidence indicates that intervertebral disc degeneration (IDD) is associated with diabetes mellitus (DM), whi...
PINK1 protects against dendritic cell dysfunction during sepsis through the regulation of mitochondrial quality control
PINK1 protects against dendritic cell dysfunction during sepsis through the regulation of mitochondrial quality control
Dendritic cell (DC) dysfunction plays a central role in sepsis-induced immunosuppression. Recent research has indicated th...
An engineered miRNA PS-OMe miR130 inhibits acute lung injury by targeting eCIRP in sepsis
An engineered miRNA PS-OMe miR130 inhibits acute lung injury by targeting eCIRP in sepsis
Sepsis is caused by the dysregulated immune response due to an initial infection and results in significant morbidity and ...
AAV-glycine receptor α3 alleviates CFA-induced inflammatory pain by downregulating ERK phosphorylation and proinflammatory cytokine expression in SD rats
AAV-glycine receptor α3 alleviates CFA-induced inflammatory pain by downregulating ERK phosphorylation and proinflammatory cytokine expression in SD rats
Glycine receptors (GlyRs) play key roles in the processing of inflammatory pain. The use of adeno-associated virus (AAV) v...
Role and mechanism of CD90+ fibroblasts in inflammatory diseases and malignant tumors
Role and mechanism of CD90+ fibroblasts in inflammatory diseases and malignant tumors
Fibroblasts are highly heterogeneous mesenchymal stromal cells, and different fibroblast subpopulations play different rol...
Methyltransferase-like 3 aggravates endoplasmic reticulum stress in preeclampsia by targeting TMBIM6 in YTHDF2-dependent manner
Methyltransferase-like 3 aggravates endoplasmic reticulum stress in preeclampsia by targeting TMBIM6 in YTHDF2-dependent manner
With the increasing morbidity and mortality of preeclampsia (PE), it has posed a huge challenge to public health. Previous...
Alteration in branching morphogenesis via YAP/TAZ in fibroblasts of fetal lungs in an LPS-induced inflammation model
Alteration in branching morphogenesis via YAP/TAZ in fibroblasts of fetal lungs in an LPS-induced inflammation model
Chorioamnionitis is a common cause of preterm birth and leads to serious complications in newborns. The objective of this ...
2-Hydroxy-3-methylanthraquinone inhibits homologous recombination repair in osteosarcoma through the MYC-CHK1-RAD51 axis
2-Hydroxy-3-methylanthraquinone inhibits homologous recombination repair in osteosarcoma through the MYC-CHK1-RAD51 axis
Osteosarcoma is a malignant bone tumor that usually affects adolescents aged 15–19 y. The DNA damage response (DDR) ...
Evaluation of inherited germline mutations in cancer susceptibility genes among pancreatic cancer patients: a single-center study
Evaluation of inherited germline mutations in cancer susceptibility genes among pancreatic cancer patients: a single-center study
Germline mutations in cancer susceptibility genes were identified in pancreatic cancer (PanC) patients with a sporadic dis...
Newly discovered roles of triosephosphate isomerase including functions within the nucleus
Newly discovered roles of triosephosphate isomerase including functions within the nucleus
Triosephosphate isomerase (TPI) is best known as a glycolytic enzyme that interconverts the 3-carbon sugars dihydroxyaceto...
Indole-3-propionic acid alleviates chondrocytes inflammation and osteoarthritis via the AhR/NF-κB axis
Indole-3-propionic acid alleviates chondrocytes inflammation and osteoarthritis via the AhR/NF-κB axis
Osteoarthritis (OA) is a common chronic disease characterized by chronic inflammation and extracellular matrix degradation...
Gene targeting in amyotrophic lateral sclerosis using causality-based feature selection and machine learning
Gene targeting in amyotrophic lateral sclerosis using causality-based feature selection and machine learning
Amyotrophic lateral sclerosis (ALS) is a rare progressive neurodegenerative disease that affects upper and lower motor neu...
Exploring the mechanism by which aqueous Gynura divaricata inhibits diabetic foot based on network pharmacology, molecular docking and experimental verification
Exploring the mechanism by which aqueous Gynura divaricata inhibits diabetic foot based on network pharmacology, molecular docking and experimental verification
To predict and validate the potential mechanism by which Gynura divaricata (GD) functions in the treatment of diabetic foo...
Long noncoding RNA uc007nnj.1 mediates neuronal death induced by retinal ischemia/reperfusion in mice via the miR-155-5p/Tle4 axis
Long noncoding RNA uc007nnj.1 mediates neuronal death induced by retinal ischemia/reperfusion in mice via the miR-155-5p/Tle4 axis
Retinal ganglion cells (RGCs) apoptosis is a vital manifestation of retinal ischemia/reperfusion (I/R) injury, yet the und...
Transient Receptor Potential Ankyrin-1-expressing vagus nerve fibers mediate IL-1β induced hypothermia and reflex anti-inflammatory responses
Transient Receptor Potential Ankyrin-1-expressing vagus nerve fibers mediate IL-1β induced hypothermia and reflex anti-inflammatory responses
Inflammation, the physiological response to infection and injury, is coordinated by the immune and nervous systems. Interl...
A novel Mcl-1 inhibitor synergizes with venetoclax to induce apoptosis in cancer cells
A novel Mcl-1 inhibitor synergizes with venetoclax to induce apoptosis in cancer cells
Evading apoptosis by overexpression of anti-apoptotic Bcl-2 family proteins is a hallmark of cancer cells and the Bcl-2 se...
Placental DNA methylation profile as predicting marker for autism spectrum disorder (ASD)
Placental DNA methylation profile as predicting marker for autism spectrum disorder (ASD)
Autism spectrum disorder (ASD) is a neurodevelopmental disorder that impairs normal brain development and socio-cognitive ...
Improvement of ACK1-targeted therapy efficacy in lung adenocarcinoma using chloroquine or bafilomycin A1
Improvement of ACK1-targeted therapy efficacy in lung adenocarcinoma using chloroquine or bafilomycin A1
Activated Cdc42-associated kinase 1 (ACK1) is a promising druggable target for cancer, but its inhibitors only showed mode...
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