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Surgical implantation of human adipose derived stem cells attenuates experimentally induced hepatic fibrosis in rats
Surgical implantation of human adipose derived stem cells attenuates experimentally induced hepatic fibrosis in rats
Mesenchymal stem cells (MSCs) are multipotent stromal cells and could exert hepatoprotective effects against acute liver i...
Tetrandrine inhibits RANKL-induced osteoclastogenesis by promoting the degradation of TRAIL
Tetrandrine inhibits RANKL-induced osteoclastogenesis by promoting the degradation of TRAIL
Tetrandrine, a bisbenzylisoquinoline (BBI) alkaloid extracted from Stephania tetrandra (S. Moore), and is widely used in s...
HOXA11-OS participates in lupus nephritis by targeting miR-124-3p mediating Cyr61 to regulate podocyte autophagy
HOXA11-OS participates in lupus nephritis by targeting miR-124-3p mediating Cyr61 to regulate podocyte autophagy
The long chain non-coding RNA HOXA11-OS was recently identified. Increasing studies have shown that HOXA11-OS has regulato...
SIGIRR deficiency contributes to CD4 T cell abnormalities by facilitating the IL1/C/EBPβ/TNF-α signaling axis in rheumatoid arthritis
SIGIRR deficiency contributes to CD4 T cell abnormalities by facilitating the IL1/C/EBPβ/TNF-α signaling axis in rheumatoid arthritis
Rheumatoid arthritis (RA) is a complex autoimmune disease with multiple etiological factors, among which aberrant memory C...
Relevance of the pyroptosis-related inflammasome drug targets in the Chuanxiong to improve diabetic nephropathy
Relevance of the pyroptosis-related inflammasome drug targets in the Chuanxiong to improve diabetic nephropathy
A chronic inflammatory disease caused by disturbances in metabolism, diabetic nephropathy (DN) is a chronic inflammatory d...
CircRNA AFF4 induced by KDM1A promotes osteogenic differentiation through FNDC5/Irisin pathway
CircRNA AFF4 induced by KDM1A promotes osteogenic differentiation through FNDC5/Irisin pathway
Circular RNA (circ) AFF4 was documented to regulate osteogenesis but the underlying mechanism remains to be elucidated. Th...
Pyridostigmine reduces mortality of patients with severe SARS-CoV-2 infection: A phase 2/3 randomized controlled trial
Pyridostigmine reduces mortality of patients with severe SARS-CoV-2 infection: A phase 2/3 randomized controlled trial
Respiratory failure in severe coronavirus disease 2019 (COVID-19) is associated with a severe inflammatory response. Acety...
FADD as a key molecular player in cancer progression
FADD as a key molecular player in cancer progression
Cancer is a leading disease-related cause of death worldwide. Despite advances in therapeutic interventions, cancer remain...
The role of iron metabolism in chronic diseases related to obesity
The role of iron metabolism in chronic diseases related to obesity
Obesity is one of the major public health problems threatening the world, as well as a potential risk factor for chronic m...
Efficacy of the monocarbonyl curcumin analog C66 in the reduction of diabetes-associated cardiovascular and kidney complications
Efficacy of the monocarbonyl curcumin analog C66 in the reduction of diabetes-associated cardiovascular and kidney complications
Curcumin is a polyphenolic compound derived from turmeric that has potential beneficial properties for cardiovascular and ...
MCM2 in human cancer: functions, mechanisms, and clinical significance
MCM2 in human cancer: functions, mechanisms, and clinical significance
Aberrant DNA replication is the main source of genomic instability that leads to tumorigenesis and progression. MCM2, a co...
Inhibition of platelet activation suppresses reactive enteric glia and mitigates intestinal barrier dysfunction during sepsis
Inhibition of platelet activation suppresses reactive enteric glia and mitigates intestinal barrier dysfunction during sepsis
Intestinal barrier dysfunction, which is associated with reactive enteric glia cells (EGCs), is not only a result of early...
AAV-ie-mediated UCP2 overexpression accelerates inner hair cell loss during aging in vivo
AAV-ie-mediated UCP2 overexpression accelerates inner hair cell loss during aging in vivo
Uncoupling protein 2 (UCP2), activated by excessive reactive oxygen species (ROS) in vivo, has the dual effect of reducing...
Elevated vascular transformation blood biomarkers in Long-COVID indicate angiogenesis as a key pathophysiological mechanism
Elevated vascular transformation blood biomarkers in Long-COVID indicate angiogenesis as a key pathophysiological mechanism
Long-COVID is characterized by prolonged, diffuse symptoms months after acute COVID-19. Accurate diagnosis and targeted th...
c-Jun-mediated miR-19b expression induces endothelial barrier dysfunction in an in vitro model of hemorrhagic shock
c-Jun-mediated miR-19b expression induces endothelial barrier dysfunction in an in vitro model of hemorrhagic shock
Our previous data demonstrated that miR-19b expression was increased in human lung microvascular endothelial cells in-vitr...
Targeting miR-21 in spinal cord injuries: a game-changer?
Targeting miR-21 in spinal cord injuries: a game-changer?
Spinal cord injury (SCI) is a devastating neurological state causing physical disability, psychological stress and financi...
Induction of ferroptosis promotes vascular smooth muscle cell phenotypic switching and aggravates neointimal hyperplasia in mice
Induction of ferroptosis promotes vascular smooth muscle cell phenotypic switching and aggravates neointimal hyperplasia in mice
Stent implantation-induced neointima formation is a dominant culprit in coronary artery disease treatment failure after pe...
PACS-2 deficiency in tubular cells aggravates lipid-related kidney injury in diabetic kidney disease
PACS-2 deficiency in tubular cells aggravates lipid-related kidney injury in diabetic kidney disease
Lipid accumulation in tubular cells plays a key role in diabetic kidney disease (DKD). Targeting lipid metabolism disorder...
LncRNA KCNQ1OT1 promotes the metastasis of ovarian cancer by increasing the methylation of EIF2B5 promoter
LncRNA KCNQ1OT1 promotes the metastasis of ovarian cancer by increasing the methylation of EIF2B5 promoter
Long non-coding RNAs (lncRNAs) have emerged as regulators of human malignancies, including ovarian cancer (OC). LncRNA KCN...
Immunoglobulin G N-glycan, inflammation and type 2 diabetes in East Asian and European populations: a Mendelian randomization study
Immunoglobulin G N-glycan, inflammation and type 2 diabetes in East Asian and European populations: a Mendelian randomization study
Immunoglobulin G (IgG) N-glycans have been shown to be associated with the risk of type 2 diabetes (T2D) and its risk fact...
O-GlcNAcylation: an important post-translational modification and a potential therapeutic target for cancer therapy
O-GlcNAcylation: an important post-translational modification and a potential therapeutic target for cancer therapy
O-linked β-d-N-acetylglucosamine (O-GlcNAc) is an important post-translational modification of serine or threonine re...