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STK16 promoted colorectal cancer progress in a c-MYC signaling-dependent manner
STK16 promoted colorectal cancer progress in a c-MYC signaling-dependent manner
Colorectal cancer standed as a global health challenge, ranking third in cancer incidence and second in cancer-related dea...
The plasma proteome differentiates the multisystem inflammatory syndrome in children (MIS-C) from children with SARS-CoV-2 negative sepsis
The plasma proteome differentiates the multisystem inflammatory syndrome in children (MIS-C) from children with SARS-CoV-2 negative sepsis
The Multi-System Inflammatory Syndrome in Children (MIS-C) can develop several weeks after SARS-CoV-2 infection and requir...
F127-SE-tLAP thermosensitive hydrogel alleviates bleomycin-induced skin fibrosis via TGF-β/Smad pathway
F127-SE-tLAP thermosensitive hydrogel alleviates bleomycin-induced skin fibrosis via TGF-β/Smad pathway
Skin fibrosis affects the normal function of the skin. TGF-β1 is a key cytokine that affects organ fibrosis. The late...
Single-cell characterisation of tissue homing CD4 + and CD8 + T cell clones in immune-mediated refractory arthritis
Single-cell characterisation of tissue homing CD4 + and CD8 + T cell clones in immune-mediated refractory arthritis
Immune-mediated arthritis is a group of autoinflammatory diseases, where the patient’s own immune system attacks and...
Assessment of the FRET-based Teen sensor to monitor ERK activation changes preceding morphological defects in a RASopathy zebrafish model and phenotypic rescue by MEK inhibitor
Assessment of the FRET-based Teen sensor to monitor ERK activation changes preceding morphological defects in a RASopathy zebrafish model and phenotypic rescue by MEK inhibitor
RASopathies are genetic syndromes affecting development and having variable cancer predisposition. These disorders are cli...
SALL4 in gastrointestinal tract cancers: upstream and downstream regulatory mechanisms
SALL4 in gastrointestinal tract cancers: upstream and downstream regulatory mechanisms
Effective therapeutic targets and early diagnosis are major challenges in the treatment of gastrointestinal tract (GIT) ca...
Sirtuins in intervertebral disc degeneration: current understanding
Sirtuins in intervertebral disc degeneration: current understanding
Intervertebral disc degeneration (IVDD) is one of the etiologic factors of degenerative spinal diseases, which can lead to...
Iguratimod, an allosteric inhibitor of macrophage migration inhibitory factor (MIF), prevents mortality and oxidative stress in a murine model of acetaminophen overdose
Iguratimod, an allosteric inhibitor of macrophage migration inhibitory factor (MIF), prevents mortality and oxidative stress in a murine model of acetaminophen overdose
Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that has been implicated in multiple inflammatory a...
Vascular smooth muscle cells in response to cholesterol crystals modulates inflammatory cytokines release and promotes neutrophil extracellular trap formation
Vascular smooth muscle cells in response to cholesterol crystals modulates inflammatory cytokines release and promotes neutrophil extracellular trap formation
The formation and accumulation of cholesterol crystals (CC) at the lesion site is a hallmark of atherosclerosis. Although ...
Omentin-1 inhibits the development of benign prostatic hyperplasia by attenuating local inflammation
Omentin-1 inhibits the development of benign prostatic hyperplasia by attenuating local inflammation
Benign prostatic hyperplasia (BPH) is a prevalent disease affecting elderly men, with chronic inflammation being a critica...
Endoplasmic reticulum stress and therapeutic strategies in metabolic, neurodegenerative diseases and cancer
Endoplasmic reticulum stress and therapeutic strategies in metabolic, neurodegenerative diseases and cancer
The accumulation of unfolded or misfolded proteins within the endoplasmic reticulum (ER), due to genetic determinants and ...
A Journey in Science: Molecular vaccines for global child health in troubled times of anti-science
A Journey in Science: Molecular vaccines for global child health in troubled times of anti-science
My scientific life in translational medicine runs in two parallel, yet often converging paths. The first, is four-decade-l...
Involvement of Fgf2-mediated tau protein phosphorylation in cognitive deficits induced by sevoflurane in aged rats
Involvement of Fgf2-mediated tau protein phosphorylation in cognitive deficits induced by sevoflurane in aged rats
Anesthetics have been linked to cognitive alterations, particularly in the elderly. The current research delineates how Fi...
Downregulation of HMGB1 carried by macrophage-derived extracellular vesicles delays atherosclerotic plaque formation through Caspase-11-dependent macrophage pyroptosis
Downregulation of HMGB1 carried by macrophage-derived extracellular vesicles delays atherosclerotic plaque formation through Caspase-11-dependent macrophage pyroptosis
Macrophage-derived extracellular vesicle (macrophage-EV) is highly studied for its regulatory role in atherosclerosis (AS)...
Artemisinin ameliorates cognitive decline by inhibiting hippocampal neuronal ferroptosis via Nrf2 activation in T2DM mice
Artemisinin ameliorates cognitive decline by inhibiting hippocampal neuronal ferroptosis via Nrf2 activation in T2DM mice
Neuronal ferroptosis plays a critical role in the pathogenesis of cognitive deficits. The present study explored whether a...
Huntingtin HTT1a is generated in a CAG repeat-length-dependent manner in human tissues
Huntingtin HTT1a is generated in a CAG repeat-length-dependent manner in human tissues
The disease-causing mutation in Huntington disease (HD) is a CAG trinucleotide expansion in the huntingtin (HTT) gene. The...
Hypothalamic POMC neuron-specific knockout of MC4R affects insulin sensitivity by regulating Kir2.1
Hypothalamic POMC neuron-specific knockout of MC4R affects insulin sensitivity by regulating Kir2.1
Imbalance in energy regulation is a major cause of insulin resistance and diabetes. Melanocortin-4 receptor (MC4R) signali...
USF1 transcriptionally activates USP14 to drive atherosclerosis by promoting EndMT through NLRC5/Smad2/3 axis
USF1 transcriptionally activates USP14 to drive atherosclerosis by promoting EndMT through NLRC5/Smad2/3 axis
Endothelial-to-Mesenchymal Transformation (EndMT) plays key roles in endothelial dysfunction during the pathological progr...
Serotonin as a biomarker of toxin-induced Parkinsonism
Serotonin as a biomarker of toxin-induced Parkinsonism
Loss of dopaminergic neurons underlies the motor symptoms of Parkinson’s disease (PD). However stereotypical PD symp...
WSB1, as an E3 ligase, restrains myocardial ischemia–reperfusion injury by activating β-catenin signaling via promoting GSK3β ubiquitination
WSB1, as an E3 ligase, restrains myocardial ischemia–reperfusion injury by activating β-catenin signaling via promoting GSK3β ubiquitination
Reperfusion is the most effective strategy for myocardial infarct, but induces additional injury. WD repeat and SOCS box c...
Understanding blaNDM-1 gene regulation in CRKP infections: toward novel antimicrobial strategies for hospital-acquired pneumonia
Understanding blaNDM-1 gene regulation in CRKP infections: toward novel antimicrobial strategies for hospital-acquired pneumonia
The escalating challenge of Carbapenem-resistant Klebsiella pneumoniae (CRKP) in hospital-acquired pneumonia (HAP) is clos...
Role of ATF3 triggering M2 macrophage polarization to protect against the inflammatory injury of sepsis through ILF3/NEAT1 axis
Role of ATF3 triggering M2 macrophage polarization to protect against the inflammatory injury of sepsis through ILF3/NEAT1 axis
Sepsis is a systemic inflammatory response which is frequently associated with acute lung injury (ALI). Activating transcr...
G protein-coupled estrogen receptor activates PI3K/AKT/mTOR signaling to suppress ferroptosis via SREBP1/SCD1-mediated lipogenesis
G protein-coupled estrogen receptor activates PI3K/AKT/mTOR signaling to suppress ferroptosis via SREBP1/SCD1-mediated lipogenesis
Lung cancer is the leading cause of cancer-related death worldwide. The sex differences in the occurrence and fatality rat...
Exploring the therapeutic potential of isoorientin in the treatment of osteoporosis: a study using network pharmacology and experimental validation
Exploring the therapeutic potential of isoorientin in the treatment of osteoporosis: a study using network pharmacology and experimental validation
Isoorientin (ISO) is a glycosylated flavonoid with antitumor, anti-inflammatory, and antioxidant properties. However, its ...
Hypothesis of a CD137/Eomes activating axis for effector T cells in HPV oropharyngeal cancers
Hypothesis of a CD137/Eomes activating axis for effector T cells in HPV oropharyngeal cancers
Chronic Human Papilloma Virus (HPV) infection is supplanting alcohol and tobacco intoxications as the leading cause of oro...
Scleral remodeling during myopia development in mice eyes: a potential role of thrombospondin-1
Scleral remodeling during myopia development in mice eyes: a potential role of thrombospondin-1
Scleral extracellular matrix (ECM) remodeling plays a crucial role in the development of myopia, particularly in ocular ax...
Fluvoxamine inhibits Th1 and Th17 polarization and function by repressing glycolysis to attenuate autoimmune progression in type 1 diabetes
Fluvoxamine inhibits Th1 and Th17 polarization and function by repressing glycolysis to attenuate autoimmune progression in type 1 diabetes
Fluvoxamine is one of the selective serotonin reuptake inhibitors (SSRIs) that are regarded as the first-line drugs to man...
M1 cholinergic signaling in the brain modulates cytokine levels and splenic cell sub-phenotypes following cecal ligation and puncture
M1 cholinergic signaling in the brain modulates cytokine levels and splenic cell sub-phenotypes following cecal ligation and puncture
The contribution of the central nervous system to sepsis pathobiology is incompletely understood. In previous studies, adm...
Platelet-derived growth factor signaling in pericytes promotes hypothalamic inflammation and obesity
Platelet-derived growth factor signaling in pericytes promotes hypothalamic inflammation and obesity
Pericytes are a vital component of the blood–brain barrier, and their involvement in acute inflammation was recently...
Porous Se@SiO2 nanospheres alleviate diabetic retinopathy by inhibiting excess lipid peroxidation and inflammation
Porous Se@SiO2 nanospheres alleviate diabetic retinopathy by inhibiting excess lipid peroxidation and inflammation
Lipid peroxidation is a characteristic metabolic manifestation of diabetic retinopathy (DR) that causes inflammation, even...
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