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RNA editing regulates glutamatergic synapses in the frontal cortex of a molecular subtype of Amyotrophic Lateral Sclerosis
RNA editing regulates glutamatergic synapses in the frontal cortex of a molecular subtype of Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis (ALS) is a highly heterogenous neurodegenerative disorder that primarily affects upper and l...
The dual role of FSP1 in programmed cell death: resisting ferroptosis in the cell membrane and promoting necroptosis in the nucleus of THP-1 cells
The dual role of FSP1 in programmed cell death: resisting ferroptosis in the cell membrane and promoting necroptosis in the nucleus of THP-1 cells
Acute monocytic leukemia-M5 (AML-M5) remains a challenging disease due to its high morbidity and poor prognosis. In additi...
L-theanine alleviates myocardial ischemia/reperfusion injury by suppressing oxidative stress and apoptosis through activation of the JAK2/STAT3 pathway in mice
L-theanine alleviates myocardial ischemia/reperfusion injury by suppressing oxidative stress and apoptosis through activation of the JAK2/STAT3 pathway in mice
L-theanine is a unique non-protein amino acid in tea that is widely used as a safe food additive. We investigated the card...
USP38 exacerbates pressure overload-induced left ventricular electrical remodeling
USP38 exacerbates pressure overload-induced left ventricular electrical remodeling
Ubiquitin-specific protease 38 (USP38), belonging to the USP family, is recognized for its role in controlling protein deg...
Regulation of macrophage polarization by targeted metabolic reprogramming for the treatment of lupus nephritis
Regulation of macrophage polarization by targeted metabolic reprogramming for the treatment of lupus nephritis
Lupus nephritis (LN) is a severe and common manifestation of systemic lupus erythematosus (SLE) that is frequently identif...
β-hydroxybutyrate resensitizes colorectal cancer cells to oxaliplatin by suppressing H3K79 methylation in vitro and in vivo
β-hydroxybutyrate resensitizes colorectal cancer cells to oxaliplatin by suppressing H3K79 methylation in vitro and in vivo
Ketone β-hydroxybutyrate (BHB) has been reported to prevent tumor cell proliferation and improve drug resistance. How...
Wnt5a-mediated autophagy contributes to the epithelial-mesenchymal transition of human bronchial epithelial cells during asthma
Wnt5a-mediated autophagy contributes to the epithelial-mesenchymal transition of human bronchial epithelial cells during asthma
The epithelial-mesenchymal transition (EMT) of human bronchial epithelial cells (HBECs) is essential for airway remodeling...
Potential mechanisms of cancer prevention and treatment by sulforaphane, a natural small molecule compound of plant-derived
Potential mechanisms of cancer prevention and treatment by sulforaphane, a natural small molecule compound of plant-derived
Despite recent advances in tumor diagnosis and treatment technologies, the number of cancer cases and deaths worldwide con...
Pathogenic mechanisms of cardiovascular damage in COVID-19
Pathogenic mechanisms of cardiovascular damage in COVID-19
COVID-19 is a new infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS CoV-2). Since the...
Unveiling the therapeutic potential of IHMT-337 in glioma treatment: targeting the EZH2-SLC12A5 axis
Unveiling the therapeutic potential of IHMT-337 in glioma treatment: targeting the EZH2-SLC12A5 axis
Glioma is the most common malignant tumor of the central nervous system, with EZH2 playing a crucial regulatory role. This...
Iron deficiency affects oxygen transport and activates HIF1 signaling pathway to regulate phenotypic transformation of VSMC in aortic dissection
Iron deficiency affects oxygen transport and activates HIF1 signaling pathway to regulate phenotypic transformation of VSMC in aortic dissection
Aortic dissection (AD) is a macrovascular disease which is pathologically characterized by aortic media degeneration.This ...
S100A6 Regulates nucleus pulposus cell apoptosis via Wnt/β-catenin signaling pathway: an in vitro and in vivo study
S100A6 Regulates nucleus pulposus cell apoptosis via Wnt/β-catenin signaling pathway: an in vitro and in vivo study
Intervertebral disc degeneration (IDD) is a common musculoskeletal degenerative disease, which often leads to low back pai...
The implication of serum HLA-G in angiogenesis of multiple myeloma
The implication of serum HLA-G in angiogenesis of multiple myeloma
Despite the advances of therapies, multiple myeloma (MM) remains an incurable hematological cancer that most patients expe...
Inhibition of tartrate-resistant acid phosphatase 5 can prevent cardiac fibrosis after myocardial infarction
Inhibition of tartrate-resistant acid phosphatase 5 can prevent cardiac fibrosis after myocardial infarction
Myocardial infarction (MI) leads to enhanced activity of cardiac fibroblasts (CFs) and abnormal deposition of extracellula...
Modulation of anti-cardiac fibrosis immune responses by changing M2 macrophages into M1 macrophages
Modulation of anti-cardiac fibrosis immune responses by changing M2 macrophages into M1 macrophages
Macrophages play a crucial role in the development of cardiac fibrosis (CF). Although our previous studies have shown that...
ERRFI1 exacerbates hepatic ischemia reperfusion injury by promoting hepatocyte apoptosis and ferroptosis in a GRB2-dependent manner
ERRFI1 exacerbates hepatic ischemia reperfusion injury by promoting hepatocyte apoptosis and ferroptosis in a GRB2-dependent manner
Programmed cell death is an important mechanism for the development of hepatic ischemia and reperfusion (IR) injury, and m...
Multi-omics analysis uncovered systemic lupus erythematosus and COVID-19 crosstalk
Multi-omics analysis uncovered systemic lupus erythematosus and COVID-19 crosstalk
Studies have highlighted a possible crosstalk between the pathogeneses of COVID-19 and systemic lupus erythematosus (SLE);...
Aerobic exercise-induced HIF-1α upregulation in heart failure: exploring potential impacts on MCT1 and MPC1 regulation
Aerobic exercise-induced HIF-1α upregulation in heart failure: exploring potential impacts on MCT1 and MPC1 regulation
The terminal stage of ischemic heart disease develops into heart failure (HF), which is characterized by hypoxia and metab...
HOXD9 regulated mitophagy to promote endothelial progenitor cells angiogenesis and deep vein thrombosis recanalization and resolution
HOXD9 regulated mitophagy to promote endothelial progenitor cells angiogenesis and deep vein thrombosis recanalization and resolution
Deep vein thrombosis (DVT) is a common vascular surgical disease caused by the coagulation of blood in the deep veins, and...
The analysis of the skeletal muscle metabolism is crucial for designing optimal exercise paradigms in type 2 diabetes mellitus
The analysis of the skeletal muscle metabolism is crucial for designing optimal exercise paradigms in type 2 diabetes mellitus
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease that commonly results from a high-calorie diet and sedentar...
Wogonin upregulates SOCS3 to alleviate the injury in Diabetic Nephropathy by inhibiting TLR4-mediated JAK/STAT/AIM2 signaling pathway
Wogonin upregulates SOCS3 to alleviate the injury in Diabetic Nephropathy by inhibiting TLR4-mediated JAK/STAT/AIM2 signaling pathway
Diabetic nephropathy (DN) is a life-threatening renal disease and needs urgent therapies. Wogonin is renoprotective in DN....
CYP2E1 deficit mediates cholic acid-induced malignant growth in hepatocellular carcinoma cells
CYP2E1 deficit mediates cholic acid-induced malignant growth in hepatocellular carcinoma cells
Increased level of serum cholic acid (CA) is often accompanied with decreased CYP2E1 expression in hepatocellular carcinom...
Icariin improves oxidative stress injury during ischemic stroke via inhibiting mPTP opening
Icariin improves oxidative stress injury during ischemic stroke via inhibiting mPTP opening
Ischemic stroke presents a significant threat to human health due to its high disability rate and mortality. Currently, th...
Advanced glycation end product-modified low-density lipoprotein promotes pro-osteogenic reprogramming via RAGE/NF-κB pathway and exaggerates aortic valve calcification in hamsters
Advanced glycation end product-modified low-density lipoprotein promotes pro-osteogenic reprogramming via RAGE/NF-κB pathway and exaggerates aortic valve calcification in hamsters
Advanced glycation end product-modified low-density lipoprotein (AGE-LDL) is related to inflammation and the development o...
Inhibition of CC chemokine receptor 1 ameliorates osteoarthritis in mouse by activating PPAR-γ
Inhibition of CC chemokine receptor 1 ameliorates osteoarthritis in mouse by activating PPAR-γ
Osteoarthritis (OA) is a degenerative joint disease characterized by cartilage destruction and inflammation. CC chemokine ...
Rab3B enhances the stabilization of DDX6 to promote lung adenocarcinoma aggressiveness
Rab3B enhances the stabilization of DDX6 to promote lung adenocarcinoma aggressiveness
Liver kinase B1 (LKB1) is frequently mutated in lung adenocarcinoma, and its loss contributes to tumor progression. To ide...
FK228 suppress the growth of human malignant pleural mesothelioma tumor independent to epithelioid or non-epithelioid histology
FK228 suppress the growth of human malignant pleural mesothelioma tumor independent to epithelioid or non-epithelioid histology
Human malignant pleural mesothelioma (hMPM) is an aggressive, rare disease with a poor prognosis. Histologically, MPM is c...
Inhibition of OGG1 ameliorates pulmonary fibrosis via preventing M2 macrophage polarization and activating PINK1-mediated mitophagy
Inhibition of OGG1 ameliorates pulmonary fibrosis via preventing M2 macrophage polarization and activating PINK1-mediated mitophagy
8-Oxoguanine DNA glycosylase (OGG1), a well-known DNA repair enzyme, has been demonstrated to promote lung fibrosis, while...
An update on chronic complications of diabetes mellitus: from molecular mechanisms to therapeutic strategies with a focus on metabolic memory
An update on chronic complications of diabetes mellitus: from molecular mechanisms to therapeutic strategies with a focus on metabolic memory
Diabetes mellitus, a chronic metabolic disease, often leads to numerous chronic complications, significantly contributing ...
ECHDC2 inhibits the proliferation of gastric cancer cells by binding with NEDD4 to degrade MCCC2 and reduce aerobic glycolysis
ECHDC2 inhibits the proliferation of gastric cancer cells by binding with NEDD4 to degrade MCCC2 and reduce aerobic glycolysis
The Enoyl-CoA hydratase/isomerase family plays a crucial role in the metabolism of tumors, being crucial for maintaining t...
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