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The complex role of inflammation and gliotransmitters in Parkinson's disease
Our understanding of the role of innate and adaptive immune cell function in brain health and how it goes awry during agin...
Plasma neurofilament light chain in memory clinic practice: Evidence from a real-life study
ObjectiveTo explore the accuracy of plasma neurofilament light chain (NfL) as a biomarker for diagnosis and staging of cog...
Structural and functional abnormalities in thalamic neurons following neocortical focal status epilepticus
Status epilepticus (SE) is a life-threatening emergency that can result in de novo development or worsening of epilepsy. W...
Selective activation of striatal indirect pathway suppresses levodopa induced-dyskinesias
Levodopa (L-DOPA) administration remains the gold standard therapy for Parkinson's disease (PD). Despite several pharmacol...
Activation of Swell1 in microglia suppresses neuroinflammation and reduces brain damage in ischemic stroke
Cl− movement and Cl−-sensitive signal pathways contributes to the survival and switch of inflammatory phenotype of microgl...
Longitudinal spatial mapping of lipid metabolites reveals pre-symptomatic changes in the hippocampi of Huntington's disease transgenic mice
In Huntington's disease (HD), a key pathological feature includes the development of inclusion-bodies of fragments of the ...
Translatomic response of retinal Müller glia to acute and chronic stress
Analysis of retina cell type-specific epigenetic and transcriptomic signatures is crucial to understanding the pathophysio...
Delta oscillation coupled propagating fast ripples precede epileptiform discharges in patients with focal epilepsy
Volume 175, December 2022, 105928Author links open overlay panelHighlights•FR are most probable on or within +/− 400 ms of...
C9orf72 repeat length might influence clinical sub-phenotypes in dementia patients
BackgroundC9orf72 repeat expansions have been observed in a wide variety of neurodegenerative disorders. The cut-off betwe...
Deficiency of astrocyte CysLT1R ameliorates depression-like behaviors in mice by modulating glutamate synaptic transmission
Our previous study suggests that hippocampal cysteinyl leukotriene receptor 1 (CysLT1R) could be involved in depression. H...
Genetic risk for insomnia is associated with objective sleep measures in young and healthy good sleepers
Insomnia disorder (ID) is the second most common neuropsychiatric disorder. Its socioeconomic burden is enormous while dia...
Molecular heterogeneity in the substantia nigra: A roadmap for understanding PD motor pathophysiology
As the ability to capture single-cell expression profiles has grown in recent years, neuroscientists studying a wide gamut...
Thioredoxin deficiency increases oxidative stress and causes bilateral symmetrical degeneration in rat midbrain
Thioredoxin (TXN), encoded by Txn1, acts as a critical antioxidant in the defense against oxidative stress by regulating t...
Blood brain barrier and inflammation in depression
The blood brain barrier (BBB) is a vital structure to protect the brain, tightly filtering the passage of nutrients and mo...
Genuine high-order interactions in brain networks and neurodegeneration
Brain functional networks have been traditionally studied considering only interactions between pairs of regions, neglecti...
Cathepsin D: Analysis of its potential role as an amyloid beta degrading protease
Proteolysis catalyzed by the major lysosomal aspartyl protease cathepsin-D (CTSD) appears to be of pivotal importance for ...
Chemotherapy promotes astrocytic response to Aβ deposition, but not Aβ levels, in a mouse model of amyloid and APOE
Many cancer survivors experience cancer-related cognitive impairment (CRCI), which is characterized by problems of attenti...
LRRK2 protects immune cells against erastin-induced Ferroptosis
Ferroptosis is an iron-dependent regulated cell death pathway characterized by excessive lipid peroxidation. It is implica...
Introduction to the special issue on neurological disorders across the female life span
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Deep brain stimulation in animal models of dystonia
During the last decades deep brain stimulation (DBS) has become an important treatment option for a variety of neurologica...
Genetic analysis of and clinical characteristics associated with ANXA11 variants in a Chinese cohort with amyotrophic lateral sclerosis
BackgroundVariants in the annexin A11 gene (ANXA11) have been reported to be associated with amyotrophic lateral sclerosis...
Rethinking the cilia hypothesis of hydrocephalus
Dysfunction of motile cilia in ependymal cells has been proposed to be a pathogenic cause of cerebrospinal fluid (CSF) ove...
The contribution of spinal dorsal horn astrocytes in neuropathic pain at the early stage of EAE
Reactive astrocytes play a complex role in multiple sclerosis, and the astrocytes reactivity is an important factor in the...
Cerebellar deep brain stimulation for movement disorders
Deep brain stimulation (DBS) conventionally target at basal ganglia or thalamic structures, modulating nodal points in the...