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Harmonization of CSF and imaging biomarkers for Alzheimer's disease: Need and practical applications for genetics studies and preclinical classification
Harmonization of CSF and imaging biomarkers for Alzheimer's disease: Need and practical applications for genetics studies and preclinical classification
In Alzheimer's disease (AD) research, cerebrospinal fluid (CSF) Amyloid beta (Aβ), Tau and pTau are the most accepted and ...
The effects of P2 segment of posterior cerebral artery to thalamus blood supply pattern on gait in cerebral small vessel disease: A 7 T MRI based study
The effects of P2 segment of posterior cerebral artery to thalamus blood supply pattern on gait in cerebral small vessel disease: A 7 T MRI based study
Keywords7 T MRIThalamusCerebral small vessel diseasePosterior cerebral arteryGaitAbbreviationsAAL3automated anatomical lab...
Differential profiles of serum cytokines in Parkinson's disease according to disease duration
Differential profiles of serum cytokines in Parkinson's disease according to disease duration
ObjectiveNeurodegeneration and neuroinflammation are two intertwined mechanisms contributing to the pathophysiology of Par...
PI3K signaling promotes formation of lipid-laden foamy macrophages at the spinal cord injury site
PI3K signaling promotes formation of lipid-laden foamy macrophages at the spinal cord injury site
After spinal cord injury (SCI), infiltrating macrophages undergo excessive phagocytosis of myelin and cellular debris, for...
Predicting neurodegeneration from sleep related biofluid changes
Predicting neurodegeneration from sleep related biofluid changes
Sleep-wake disturbances are common in neurodegenerative diseases and may occur years before the clinical diagnosis, potent...
Antisense oligonucleotide-mediated disruption of HTT caspase-6 cleavage site ameliorates the phenotype of YAC128 Huntington disease mice
Antisense oligonucleotide-mediated disruption of HTT caspase-6 cleavage site ameliorates the phenotype of YAC128 Huntington disease mice
KeywordsHuntington diseaseYAC128 miceAntisense oligonucleotidesCaspase-6RNA splicingRNA sequence analysisMRIAbbreviationsa...
Proteomic analysis of X-linked dystonia parkinsonism disease striatal neurons reveals altered RNA metabolism and splicing
Proteomic analysis of X-linked dystonia parkinsonism disease striatal neurons reveals altered RNA metabolism and splicing
KeywordsNeurodegenerationX-linked dystonia parkinsonism diseaseInduced pluripotent stem cellsMedium spiny neuronsQuantitat...
External segment of the globus pallidus in health and disease: Its interactions with the striatum and subthalamic nucleus
External segment of the globus pallidus in health and disease: Its interactions with the striatum and subthalamic nucleus
KeywordsExternal segment of the globus pallidusStriatumSubthalamic nucleusParkinson's diseaseMovement disordersDeep brain ...
Characterisation and prion transmission study in mice with genetic reduction of sporadic Creutzfeldt-Jakob disease risk gene Stx6
Characterisation and prion transmission study in mice with genetic reduction of sporadic Creutzfeldt-Jakob disease risk gene Stx6
KeywordsPrion diseaseCreutzfeldt-Jakob diseaseSNARESyntaxin-6Incubation periodAbbreviationssCJDsporadic Creutzfeldt-Jakob ...
Ganglioglioma cells potentiate neuronal network synchronicity and elicit burst discharges via released factors
Ganglioglioma cells potentiate neuronal network synchronicity and elicit burst discharges via released factors
Gangliogliomas (GGs) represent the most frequent glioneuronal tumor entity associated with chronic recurrent seizures; rar...
Activin A targets extrasynaptic NMDA receptors to ameliorate neuronal and behavioral deficits in a mouse model of Huntington disease
Activin A targets extrasynaptic NMDA receptors to ameliorate neuronal and behavioral deficits in a mouse model of Huntington disease
Cortical-striatal synaptic dysfunction, including enhanced toxic signaling by extrasynaptic N-methyl-d-aspartate receptors...
Sex-specific developmental alterations in DYRK1A expression in the brain of a down syndrome mouse model
Sex-specific developmental alterations in DYRK1A expression in the brain of a down syndrome mouse model
Aberrant neurodevelopment in Down syndrome (DS)—caused by triplication of human chromosome 21—is commonly attributed to ge...
Cell-type brain-region specific changes in prefrontal cortex of a mouse model of alcohol dependence
Cell-type brain-region specific changes in prefrontal cortex of a mouse model of alcohol dependence
KeywordsAlcohol dependenceChronic intermittent ethanol exposureAlcohol dependence cell-type specific responsesSingle nucle...
Projection-defined median raphe Pet+ subpopulations are diversely implicated in seizure
Projection-defined median raphe Pet+ subpopulations are diversely implicated in seizure
The raphe nuclei, the primary resource of forebrain 5-HT, play an important but heterogeneous role in regulating subcortic...
Polygenic risk scores for Alzheimer's disease in relation to cognitive change: A representative sample from the general population followed over 16 years.
Polygenic risk scores for Alzheimer's disease in relation to cognitive change: A representative sample from the general population followed over 16 years.
BackgroundPolygenic risk scores for Alzheimer's disease (AD-PRSs) have been associated with cognition. However, few studie...
Gray matter structural covariance networks patterns associated with autopsy-confirmed LATE-NC compared to Alzheimer's disease pathology
Gray matter structural covariance networks patterns associated with autopsy-confirmed LATE-NC compared to Alzheimer's disease pathology
KeywordsLATE-NCLimbic TDP-43Alzheimer's diseaseMixed pathologyGray matter structural covarianceAutopsyAbbreviationsLATElim...
Trajectories of CSF and plasma biomarkers across Alzheimer's disease continuum: Disease staging by NF-L, p-tau181, and GFAP
Trajectories of CSF and plasma biomarkers across Alzheimer's disease continuum: Disease staging by NF-L, p-tau181, and GFAP
CSF-to-plasma transition will open new avenues for molecular phenotyping of Alzheimer's disease (AD). Here we evaluated a ...
Hippocampal seizures differentially modulate locus coeruleus activity and result in consistent time-locked release of noradrenaline in rat hippocampus
Hippocampal seizures differentially modulate locus coeruleus activity and result in consistent time-locked release of noradrenaline in rat hippocampus
The locus coeruleus (LC) is a small brainstem nucleus and is the sole source of noradrenaline in the neocortex, hippocampu...
Investigating brain alterations in the Dp1Tyb mouse model of Down syndrome
Investigating brain alterations in the Dp1Tyb mouse model of Down syndrome
Down syndrome (DS) is one of the most common birth defects and the most prevalent genetic form of intellectual disability....
Formation of templated inclusions in a forebrain α-synuclein mouse model is independent of LRRK2
Formation of templated inclusions in a forebrain α-synuclein mouse model is independent of LRRK2
Leucine-rich repeat kinase 2 (LRRK2) and α-synuclein share enigmatic roles in the pathobiology of Parkinson's disease (PD)...
Maternal choline supplementation protects against age-associated cholinergic and GABAergic basal forebrain neuron degeneration in the Ts65Dn mouse model of Down syndrome and Alzheimer's disease
Maternal choline supplementation protects against age-associated cholinergic and GABAergic basal forebrain neuron degeneration in the Ts65Dn mouse model of Down syndrome and Alzheimer's disease
KeywordsDown syndromeAlzheimer's diseaseMaternal choline supplementationBasal forebrain cholinergic neuronsMedial septumPa...
A novel cell-permeable peptide prevents protein SUMOylation and supports the mislocalization and aggregation of TDP-43
A novel cell-permeable peptide prevents protein SUMOylation and supports the mislocalization and aggregation of TDP-43
SUMOylation is a post-translational modification (PTM) that exerts a regulatory role in different cellular processes, incl...
Exploring the heterogeneous transcriptional response of the CNS to systemic LPS and Poly(I:C)
Exploring the heterogeneous transcriptional response of the CNS to systemic LPS and Poly(I:C)
KeywordsNeuroinflammationSingle nucleus RNA sequencing (snRNAseq)Pathogen-associated molecular pattern (PAMP)Interferon si...
RICH2 decreases the mitochondrial number and affects mitochondrial localization in diffuse low-grade glioma-related epilepsy
RICH2 decreases the mitochondrial number and affects mitochondrial localization in diffuse low-grade glioma-related epilepsy
Epilepsy, a common complication of diffuse low-grade gliomas (DLGGs; diffuse oligodendroglioma and astrocytoma collectivel...
Neuronal MeCP2 in the dentate gyrus regulates mossy fiber sprouting of mice with temporal lobe epilepsy
Neuronal MeCP2 in the dentate gyrus regulates mossy fiber sprouting of mice with temporal lobe epilepsy
Sprouting of mossy fibers, one of the most consistent findings in tissue from patients with mesial temporal lobe epilepsy,...
Boolean analysis shows a high proportion of dopamine D2 receptors interacting with adenosine A2A receptors in striatal medium spiny neurons of mouse and non-human primate models of Parkinson's disease
Boolean analysis shows a high proportion of dopamine D2 receptors interacting with adenosine A2A receptors in striatal medium spiny neurons of mouse and non-human primate models of Parkinson's disease
KeywordsGPCRs in heteromersDirect pathwayIndirect pathwayLevodopaReceptor-receptor interactionDyskinesiaMPTPAbbreviationsA...
Laminar organization of neocortical activities during systemic anoxia
Laminar organization of neocortical activities during systemic anoxia
The neocortex is highly susceptible to metabolic dysfunction. When exposed to global ischemia or anoxia, it suffers a slow...
Phenotypic effect of GBA1 variants in individuals with and without Parkinson's disease: The RAPSODI study
Phenotypic effect of GBA1 variants in individuals with and without Parkinson's disease: The RAPSODI study
Anonymised participant level data are reported as supplementary material in the file named “Aparticipant-level data”.All o...
Clearance dysfunction of trans-barrier transport and lymphatic drainage in cerebral small vessel disease: Review and prospect
Clearance dysfunction of trans-barrier transport and lymphatic drainage in cerebral small vessel disease: Review and prospect
KeywordsCerebral small vessel diseaseBlood-brain barrierBlood–cerebrospinal fluid barrierGlymphatic systemMeningeal lympha...
Regulatory T cells: A suppressor arm in post-stroke immune homeostasis
Regulatory T cells: A suppressor arm in post-stroke immune homeostasis
The activation of the immune system and the onset of pro- and anti-inflammatory responses play crucial roles in the pathop...
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