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VRK1 variants at the cross road of Cajal body neuropathogenic mechanisms in distal neuropathies and motor neuron diseases
KeywordsVRK1Distal neuropathiesSMNSMAALSCharcot-Marie-ToothHereditary spastic paraplegiaAbbreviationsVRK1Vaccinia-related ...
Social and non-social working memory in neurodegeneration
KeywordsWorking memorysocial processingsocial working memorybehavioral-variant frontotemporal dementiaAlzheimer’s diseaseP...
Pain sensitivity related to gamma oscillation of parvalbumin interneuron in primary somatosensory cortex in Dync1i1−/− mice
Cytoplasmic dynein is an important intracellular motor protein that plays an important role in neuronal growth, axonal pol...
PDZD8-mediated endoplasmic reticulum–mitochondria associations regulate sympathetic drive and blood pressure through the intervention of neuronal mitochondrial homeostasis in stress-induced hypertension
KeywordsEndoplasmic reticulum–mitochondria associationsMitochondrial dysfunctionPDZD8Rostral ventrolateral medullaStress-i...
Liquid − liquid phase separation of tau: Driving forces, regulation, and biological implications
KeywordsPhase transitionProtein aggregationTauopathiesNeurodegenerative diseaseBiomolecular condensateAbbreviationsPTMspos...
Detection of subclinical epileptiform discharges in Alzheimer's disease using long-term outpatient EEG monitoring
BackgroundIn patients with Alzheimer's disease (AD) without clinical seizures, up to half have epileptiform discharges on ...
Sex differences in anxiety and threat avoidance in GAD65 knock-out mice
Anxiety disorders have been linked to a disbalance of excitation and inhibition in a network of brain structures comprisin...
Glutamatergic and GABAergic neurons in the vLGN mediate the nociceptive effects of green and red light on neuropathic pain
Phototherapy is an emerging non-pharmacological treatment for depression, circadian rhythm disruptions, and neurodegenerat...
The cerebellum's understated role and influences in the epilepsies
Approximately 1 in 26 people will develop epilepsy in their lifetime, but current treatment options leave as many as half ...
A mitochondrial-targeted antioxidant (MitoQ) improves motor coordination and reduces Purkinje cell death in a mouse model of ARSACS
KeywordsAtaxiaAutosomal-recessive spastic ataxia of the Charlevoix-SaguenayARSACSMitoQMitochondriaPurkinje cellCerebellumC...
Natural killer cells in aging and age-related diseases
Aging leads to escalated systemic inflammation. As the sentinel of immune system, natural killer (NK) cells are early resp...
Mechanisms of cerebrospinal fluid and brain interstitial fluid production
Fluid homeostasis is fundamental for brain function with cerebral edema and hydrocephalus both being major neurological co...
Super-resolution imaging pinpoints the periodic ultrastructure at the human node of Ranvier and its disruption in patients with polyneuropathy
KeywordsSuper resolution microscopydSTORMDeep learningNerve biopsiesPolyneuropathyNode of RanvierAxoglial complexCaspr-1Ne...
Contribution of activating lateral hypothalamus-lateral habenula circuit to nerve trauma-induced neuropathic pain in mice
Neuropathic pain, a severe clinical symptom, significantly affects the quality of life in the patients. The molecular mech...
Uncovering a neurological protein signature for severe COVID-19
KeywordsSevere COVID-19Neurological complicationsOlink proteomicsProtein signatureAbbreviationsACVRL1Activin A Receptor Li...
mTOR pathway: Insights into an established pathway for brain mosaicism in epilepsy
The mechanistic target of rapamycin (mTOR) signaling pathway is an essential regulator of numerous cellular activities suc...
Pallidal activities during sleep and sleep decoding in dystonia, Huntington's, and Parkinson's disease
KeywordsDeep brain stimulationMovement disordersSleep disordersBasal ganglia, local field potentialAbbreviationsDBSdeep br...
Impaired motor unit recovery and maintenance in a knock-in mouse model of ALS-associated Kif5a variant
Kinesin family member 5A (KIF5A) is an essential, neuron-specific microtubule-associated motor protein responsible for the...
Using stable isotope tracing to unravel the metabolic components of neurodegeneration: Focus on neuron-glia metabolic interactions
KeywordsBrain energy metabolismAstrocytesMass spectrometryNeurodegenerative disordersAlzheimer's diseaseParkinson's diseas...
Most dystrophic neurites in the common 5xFAD Alzheimer mouse model originate from axon terminals
How dystrophic neurites form around amyloid plaques is a key aspect of understanding the early pathophysiology of Alzheime...
Early-onset brain alterations during postnatal development in a mouse model of CDKL5 deficiency disorder
Mutations in the CDKL5 gene are the cause of CDKL5 deficiency disorder (CDD), a rare and severe neurodevelopmental conditi...
YIPF5 (p.W218R) mutation induced primary microcephaly in rabbits
Primary microcephaly (PMCPH) is a rare autosomal recessive neurodevelopmental disorder with a global prevalence of PMCPH r...
Alterations to parvalbumin-expressing interneuron function and associated network oscillations in the hippocampal – medial prefrontal cortex circuit during natural sleep in AppNL-G-F/NL-G-F mice
In the early stages of Alzheimer's disease (AD), the accumulation of the peptide amyloid-β (Aβ) damages synapses and disru...
BACE cleavage of APP does not drive the diabetic phenotype of PLB4 mice
BackgroundAlzheimer's Disease (AD) and Type 2 Diabetes Mellitus (T2DM), two prevalent diseases related to ageing, often sh...
Ellagic acid and its metabolites urolithins A/B ameliorate most common disease phenotypes in cellular and mouse models for lysosomal storage disorders by enhancing extracellular vesicle secretion
KeywordsExtracellular vesiclesPolyphenolsLysosomal storage disordersNiemann pickBrainAbbreviationsASMkoacid sphingomyelina...
Protective Alzheimer's disease-associated APP A673T variant predominantly decreases sAPPβ levels in cerebrospinal fluid and 2D/3D cell culture models
The rare A673T variant was the first variant found within the amyloid precursor protein (APP) gene conferring protection a...
FTD-associated behavioural and transcriptomic abnormalities in ‘humanized’ progranulin-deficient mice: A novel model for progranulin-associated FTD
KeywordsProgranulinFrontotemporal dementiaHumanized micePreclinical model, RNAseqAbbreviationsBACBacterial artificial chro...
FMRP phosphorylation and interactions with Cdh1 regulate association with dendritic RNA granules and MEF2-triggered synapse elimination
Fragile X Messenger Ribonucleoprotein (FMRP) is necessary for experience-dependent, developmental synapse elimination and ...
From phenomenological to biophysical models of seizures
Epilepsy is a complex disease that requires various approaches for its study. This short review discusses the contribution...
Short-term plasticity of the motor cortex compensates for bradykinesia in Parkinson’s disease
Patients with Parkinson's disease (PD) show impaired short-term potentiation (STP) mechanisms in the primary motor cortex ...
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