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The road ahead: a brief guide to navigating the 2022 WHO classification of endocrine and neuroendocrine tumours
The road ahead: a brief guide to navigating the 2022 WHO classification of endocrine and neuroendocrine tumours
IntroductionEndocrine pathology is an evolving field, in which morphological assessment integrated with immunohistochemica...
Whole slide imaging of tumour microenvironment in classical Hodgkins lymphoma: development of a clinical prediction model based on programmed death-ligand 1 and tumorous Reed-Sternberg cells
Whole slide imaging of tumour microenvironment in classical Hodgkins lymphoma: development of a clinical prediction model based on programmed death-ligand 1 and tumorous Reed-Sternberg cells
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Impact of consensus molecular subtypes on survival with and without adjuvant chemotherapy in muscle-invasive urothelial bladder cancer
Impact of consensus molecular subtypes on survival with and without adjuvant chemotherapy in muscle-invasive urothelial bladder cancer
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Lymphoma triage from H&E using AI for improved clinical management
Lymphoma triage from H&E using AI for improved clinical management
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c-Met immunohistochemistry as reflex test at diagnosis for non-small cell lung cancer: a real-world experience from a monocentric case series
c-Met immunohistochemistry as reflex test at diagnosis for non-small cell lung cancer: a real-world experience from a monocentric case series
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Histological features of liver disease development in the Atp7b-/- mouse: a model of Wilsons disease
Histological features of liver disease development in the Atp7b-/- mouse: a model of Wilsons disease
WHAT IS ALREADY KNOWN ON THIS TOPICWHAT THIS STUDY ADDSHerein are reported the progressive stages of liver injury due to c...
Molecular subtypes, predictive markers and prognosis in small-cell lung carcinoma
Molecular subtypes, predictive markers and prognosis in small-cell lung carcinoma
WHAT IS ALREADY KNOWN ON THIS TOPICAlthough small-cell lung carcinoma (SCLC) molecular subtype classification was observed...
Primary desmoplastic small round cell tumour of the prostate
Primary desmoplastic small round cell tumour of the prostate
BackgroundDesmoplastic small round cell tumour (DSRCT) is a highly aggressive soft-tissue sarcoma that primarily affects c...
Genetic variations of type 2 and type 3 von Willebrand diseases in Thailand
Genetic variations of type 2 and type 3 von Willebrand diseases in Thailand
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Severe antigen excess confounding the detection of Plasmodium falciparum via rapid antigen assay
Severe antigen excess confounding the detection of Plasmodium falciparum via rapid antigen assay
Rapid antigen tests, such as the BinaxNOW Malaria assay (Abbott Diagnostics, Scarborough, Maine, USA), provide an excellen...
Evaluating ChatGPT in pathology: towards multimodal AI in medical imaging
Evaluating ChatGPT in pathology: towards multimodal AI in medical imaging
I read with great interest the manuscript by Laohawetwanit et al, which evaluates the performance of Chat Generative Pre-t...
Molecular and haematological characterisation of haemolytic anaemia associated with biallelic KLF1 mutations: a case series
Molecular and haematological characterisation of haemolytic anaemia associated with biallelic KLF1 mutations: a case series
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Streamlining pathology orders in a time-crunched medical world: much ado about requisitions
Streamlining pathology orders in a time-crunched medical world: much ado about requisitions
I read with fascination the paper by Neil Shepherd and the letter to the editor by Pai.1–3 Both pieces address critical is...
Enteroblastic gastric cancer subtype holds therapeutic clues
Enteroblastic gastric cancer subtype holds therapeutic clues
In this issue of the Journal of Clinical Pathology, Pu and colleagues from the Nanjing University Medical School, China, r...
Phaeochromocytoma and paraganglioma
Phaeochromocytoma and paraganglioma
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Comparing the diagnostic efficacy of optical coherence tomography and frozen section for margin assessment in breast-conserving surgery: a meta-analysis
Comparing the diagnostic efficacy of optical coherence tomography and frozen section for margin assessment in breast-conserving surgery: a meta-analysis
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Does an electronic pathology ordering system change the volume and pattern of routine testing in hospital? An interrupted time series analysis
Does an electronic pathology ordering system change the volume and pattern of routine testing in hospital? An interrupted time series analysis
IntroductionWith increasing healthcare costs and an ageing population, identifying and resolving causes of low-value care ...
Altered cytokeratin 5 expression in breast lobular myoepithelial cells
Altered cytokeratin 5 expression in breast lobular myoepithelial cells
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Intraoperative evaluation of sentinel lymph nodes in patients with breast cancer treated with systemic neoadjuvant therapy
Intraoperative evaluation of sentinel lymph nodes in patients with breast cancer treated with systemic neoadjuvant therapy
WHAT IS ALREADY KNOWN ON THIS TOPICTouch preparation (TP) is an easy and rapid method to detect metastasis during intraope...
The Impact of potential 'confounders on the diagnostic sensitivity of circulating free DNA in management of FIT+ patients: a pilot study
The Impact of potential 'confounders on the diagnostic sensitivity of circulating free DNA in management of FIT+ patients: a pilot study
IntroductionMetastatic colorectal cancer (mCRC) is still one of the leading causes of death worldwide.1 Despite improvemen...
Light chain only variant of proliferative glomerulonephritis with monoclonal immunoglobulin deposits: a clinicopathological study of three cases
Light chain only variant of proliferative glomerulonephritis with monoclonal immunoglobulin deposits: a clinicopathological study of three cases
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Sample suitability and stability in different blood collection tubes for methanol, ethanol, isopropanol, acetone and glycols analysis
Sample suitability and stability in different blood collection tubes for methanol, ethanol, isopropanol, acetone and glycols analysis
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Performances of the Idylla GeneFusion Assay: contribution to a rapid diagnosis of targetable gene fusions in tumour samples
Performances of the Idylla GeneFusion Assay: contribution to a rapid diagnosis of targetable gene fusions in tumour samples
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Stability of porphyrins and porphyrin precursors in urine and plasma samples: implications for sample handling and storage
Stability of porphyrins and porphyrin precursors in urine and plasma samples: implications for sample handling and storage
The porphyrias are rare disorders of haem biosynthesis. Diagnosis requires demonstrating increased porphyrins or porphyrin...
Gene of the month: the uroplakins
Gene of the month: the uroplakins
Uroplakins are a family of membrane-spanning proteins highly specific to the urothelium. There are four uroplakin proteins...
Sudden unexpected death in a middle-aged woman
Sudden unexpected death in a middle-aged woman
Clinical presentationThe patient was a woman in her 50s with a history of migraine and Raynaud’s disease. She had episodes...
Commentary on sudden unexpected death in a middle-aged woman: spontaneous coronary artery dissection (SCAD), myocardial infarction and cardiac biomarkers
Commentary on sudden unexpected death in a middle-aged woman: spontaneous coronary artery dissection (SCAD), myocardial infarction and cardiac biomarkers
Spontaneous coronary artery dissection (SCAD) is an uncommon cause of myocardial infarction (MI). It presents clinically e...
Invited commentary on: sudden cardiac death
Invited commentary on: sudden cardiac death
Postmortem examination holds a pivotal role in our society. The implications of this procedure are vast, ranging from medi...
Investigating the relative frequencies of unascertained causes of death and advanced decomposition at autopsy
Investigating the relative frequencies of unascertained causes of death and advanced decomposition at autopsy
IntroductionAn established dogma of autopsy pathology is that it is not possible to ascertain a cause of death in about 2–...
Reducing workload in malignant melanoma sentinel node examination: a national study of pathology reports from 507 melanoma patients
Reducing workload in malignant melanoma sentinel node examination: a national study of pathology reports from 507 melanoma patients
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