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Gene of the month: the uroplakins
Gene of the month: the uroplakins
Uroplakins are a family of membrane-spanning proteins highly specific to the urothelium. There are four uroplakin proteins...
Sudden unexpected death in a middle-aged woman
Sudden unexpected death in a middle-aged woman
Clinical presentationThe patient was a woman in her 50s with a history of migraine and Raynaud’s disease. She had episodes...
Commentary on sudden unexpected death in a middle-aged woman: spontaneous coronary artery dissection (SCAD), myocardial infarction and cardiac biomarkers
Commentary on sudden unexpected death in a middle-aged woman: spontaneous coronary artery dissection (SCAD), myocardial infarction and cardiac biomarkers
Spontaneous coronary artery dissection (SCAD) is an uncommon cause of myocardial infarction (MI). It presents clinically e...
Invited commentary on: sudden cardiac death
Invited commentary on: sudden cardiac death
Postmortem examination holds a pivotal role in our society. The implications of this procedure are vast, ranging from medi...
Investigating the relative frequencies of unascertained causes of death and advanced decomposition at autopsy
Investigating the relative frequencies of unascertained causes of death and advanced decomposition at autopsy
IntroductionAn established dogma of autopsy pathology is that it is not possible to ascertain a cause of death in about 2–...
Reducing workload in malignant melanoma sentinel node examination: a national study of pathology reports from 507 melanoma patients
Reducing workload in malignant melanoma sentinel node examination: a national study of pathology reports from 507 melanoma patients
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Cystic neutrophilic granulomatous mastitis: sensitivity and specificity of 16s rRNA and Sanger sequencing for Corynebacterium spp
Cystic neutrophilic granulomatous mastitis: sensitivity and specificity of 16s rRNA and Sanger sequencing for Corynebacterium spp
WHAT IS ALREADY KNOWN ON THIS TOPICHOW THIS STUDY MIGHT AFFECT RESEARCH, PRACTICE OR POLICYNo optimal testing modality cur...
Primary salivary duct carcinoma of the lung: clinicopathological features, diagnosis and practical challenges
Primary salivary duct carcinoma of the lung: clinicopathological features, diagnosis and practical challenges
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From Castleman disease histopathological features to idiopathic multicentric Castleman disease: a multiparametric approach to exclude potential iMCD histopathological mimickers
From Castleman disease histopathological features to idiopathic multicentric Castleman disease: a multiparametric approach to exclude potential iMCD histopathological mimickers
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Correlation of immediate prevalence of cervical precancers and cancers with HPV genotype and age in women with ASC-US/hrHPV+: a retrospective analysis of 2292 cases
Correlation of immediate prevalence of cervical precancers and cancers with HPV genotype and age in women with ASC-US/hrHPV+: a retrospective analysis of 2292 cases
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Lipid droplets functional protein caveolin-2 is associated with lipid metabolism-related molecule FABP5 and EMT marker E-cadherin in oral epithelial dysplasia
Lipid droplets functional protein caveolin-2 is associated with lipid metabolism-related molecule FABP5 and EMT marker E-cadherin in oral epithelial dysplasia
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Dematiaceous fungal infections: clinical and pathologic conundrums
Dematiaceous fungal infections: clinical and pathologic conundrums
Dematiaceous fungi are defined by pigment within their cell walls. They are increasingly recognised human pathogens, causi...
Circulating IL-6 is associated with disease progression in BRAFwt metastatic melanoma patients receiving anti-PD-1 therapy
Circulating IL-6 is associated with disease progression in BRAFwt metastatic melanoma patients receiving anti-PD-1 therapy
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Rare myxoid pleomorphic liposarcoma: a case report and literature review
Rare myxoid pleomorphic liposarcoma: a case report and literature review
We report a case of a middle-aged woman with a rapidly growing abdominal mass that was diagnosed as myxoid pleomorphic lip...
Gene of the month: DDIT3
Gene of the month: DDIT3
DNA damage-inducible transcript 3 (DDIT3) gene, mapped to the human chromosome 12q13.3, encodes a protein that belongs to ...
Gender distribution in pathology journal editorial boards: a call to action
Gender distribution in pathology journal editorial boards: a call to action
The article by Nguyen et al reveals that Pathology, like other medical specialties, has an underrepresentation of women au...
Gender distribution in surgical pathology journal publications and editorial boards
Gender distribution in surgical pathology journal publications and editorial boards
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Risk assessment in pT1 colorectal cancer
Risk assessment in pT1 colorectal cancer
IntroductionColorectal cancer (CRC) is one of the most common malignancies, resulting in 16 800 deaths in the UK annually....
Expression and correlation of PD-L1 and HER2 in oesophageal squamous cell carcinoma
Expression and correlation of PD-L1 and HER2 in oesophageal squamous cell carcinoma
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Impact of cellular morphology and three-tiered nuclear grade on progression of conventional renal cell carcinoma
Impact of cellular morphology and three-tiered nuclear grade on progression of conventional renal cell carcinoma
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Comparison of assessment of programmed death-ligand 1 (PD-L1) status in triple-negative breast cancer biopsies and surgical specimens
Comparison of assessment of programmed death-ligand 1 (PD-L1) status in triple-negative breast cancer biopsies and surgical specimens
WHAT IS ALREADY KNOWN ON THIS TOPICHOW THIS STUDY MIGHT AFFECT RESEARCH, PRACTICE OR POLICYIntroductionTriple-negative bre...
Tumour-to-tumour metastasis of breast cancer (donor) and clear cell renal cell carcinoma (recipient): a case report
Tumour-to-tumour metastasis of breast cancer (donor) and clear cell renal cell carcinoma (recipient): a case report
A woman in her late 70s was referred to urology clinic to consider intervention for a biopsy-proven 24 mm WHO/Internationa...
Kinase expression in angiomatoid fibrous histiocytoma: panTRK is commonly expressed in the absence of NTRK rearrangement
Kinase expression in angiomatoid fibrous histiocytoma: panTRK is commonly expressed in the absence of NTRK rearrangement
Angiomatoid fibrous histiocytoma (AFH) is a soft tissue tumour of intermediate (rarely metastasising) malignant potential,...
Efficacy of postmortem CT and tissue sampling in establishing the cause of death in clinical practice: a prospective observational study
Efficacy of postmortem CT and tissue sampling in establishing the cause of death in clinical practice: a prospective observational study
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Non-deletional haemoglobin H (Hb H) disease morphologically masquerading as congenital dyserythropoietic anaemia type II: a diagnostic pitfall
Non-deletional haemoglobin H (Hb H) disease morphologically masquerading as congenital dyserythropoietic anaemia type II: a diagnostic pitfall
Haemoglobin H (Hb H) disease is a form of alpha (α)-thalassaemia where three of the four α-globin gene alleles are deleted...
Implementation of an ISO15189 accredited next-generation sequencing service with the fully automated Ion Torrent Genexus: the experience of a clinical diagnostic laboratory
Implementation of an ISO15189 accredited next-generation sequencing service with the fully automated Ion Torrent Genexus: the experience of a clinical diagnostic laboratory
WHAT IS ALREADY KNOWN ON THIS TOPICThis is a new concept, the implementation of an ISO15189 accredited next-generation seq...
Successful demand management in diagnostic immunology testing
Successful demand management in diagnostic immunology testing
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Modes of assay interference and the effectiveness of serum pretreatment approaches in detection of anti-HLA antibodies
Modes of assay interference and the effectiveness of serum pretreatment approaches in detection of anti-HLA antibodies
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Gene of the month: cancer testis antigen gene 1b (NY-ESO-1)
Gene of the month: cancer testis antigen gene 1b (NY-ESO-1)
IntroductionThe cancer testis antigen gene 1B (CTAG1B) was first described in 1997, with subsequent gene product, New York...
Granulomas in bone marrow biopsies: clinicopathological significance and new perspectives
Granulomas in bone marrow biopsies: clinicopathological significance and new perspectives
Bone marrow granulomas in trephine biopsies are a rare and usually incidental finding. Possible causes include infectious ...
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