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SOX10
SOX10
The SRY-related HMG-box (SOX) family of transcription factors are important in determining the differentiation of a cell d...
57-year-old woman with purpura fulminans and acute kidney injury
57-year-old woman with purpura fulminans and acute kidney injury
Clinical presentationA 57-year-old woman was admitted to Peking University First Hospital with a fever (temperature 38.5°C...
Through the looking crystal: clarifying the pathogenesis and laboratory work-up of cryocrystalglobulinaemia
Through the looking crystal: clarifying the pathogenesis and laboratory work-up of cryocrystalglobulinaemia
Cryoglobulins are immunoglobulins that precipitate or gel out of serum at temperatures less than 37°C and resolubilise on ...
Cost analysis of archives in the pathology laboratories: from safety to management
Cost analysis of archives in the pathology laboratories: from safety to management
Archives in pathology: a historical rebusThe archives in pathology are crucial, but at the same time, they are the least-o...
New autopsy technique in COVID-19 positive dead bodies: opening the thoracic cavity with an outlook to reduce aerosol spread
New autopsy technique in COVID-19 positive dead bodies: opening the thoracic cavity with an outlook to reduce aerosol spread
WHAT IS ALREADY KNOWN ON THIS TOPICPathological or Medico-legal autopsies have been the cornerstone for the determination ...
Verification and validation of the anti-PD-L1 antibody, Clone 22C3 on a laboratory-developed test
Verification and validation of the anti-PD-L1 antibody, Clone 22C3 on a laboratory-developed test
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Update regarding the role of PD-L1 in oncocytic thyroid lesions on cytological samples
Update regarding the role of PD-L1 in oncocytic thyroid lesions on cytological samples
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Interlaboratory Gleason grading variation affects treatment: a Dutch historic cohort study in 30 509 patients with prostate cancer
Interlaboratory Gleason grading variation affects treatment: a Dutch historic cohort study in 30 509 patients with prostate cancer
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Predicting the likelihood of a BRCA1/2 pathogenic variant being somatic by testing only tumour DNA in non-mucinous high-grade epithelial ovarian cancer
Predicting the likelihood of a BRCA1/2 pathogenic variant being somatic by testing only tumour DNA in non-mucinous high-grade epithelial ovarian cancer
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Automatic CD30 scoring method for whole slide images of primary cutaneous CD30+ lymphoproliferative diseases
Automatic CD30 scoring method for whole slide images of primary cutaneous CD30+ lymphoproliferative diseases
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Idylla EGFR assay on extracted DNA: advantages, limits and place in molecular screening according to the latest guidelines for non-small-cell lung cancer (NSCLC) patients
Idylla EGFR assay on extracted DNA: advantages, limits and place in molecular screening according to the latest guidelines for non-small-cell lung cancer (NSCLC) patients
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Immunohistochemical enumeration of plasma cells: manual or digital?
Immunohistochemical enumeration of plasma cells: manual or digital?
Plasma cell enumeration in bone marrow samples is a critical component in the assessment and diagnosis of plasma cell dysc...
Impact of the transition to digital pathology in a clinical setting on histopathologists in training: experiences and perceived challenges within a UK training region
Impact of the transition to digital pathology in a clinical setting on histopathologists in training: experiences and perceived challenges within a UK training region
WHAT IS ALREADY KNOWN ON THIS TOPICWhile there is an understanding of the need for guidance for histopathologists transiti...
Expression, assessment and significance of Ki67 expression in breast cancer: an update
Expression, assessment and significance of Ki67 expression in breast cancer: an update
Ki67 expression is one of the most important and cost-effective surrogate markers to assess for tumour cell proliferation ...
'Atypical, 'aggressive or 'malignant chondroblastoma? Uncertainty about uncertain malignant potential
'Atypical, 'aggressive or 'malignant chondroblastoma? Uncertainty about uncertain malignant potential
To the editorIn this month’s issue of the Journal, Zhao et al 1 have published a clinicopathological analysis of a group o...
Chondroblastoma: clinicopathological analyses of 307 cases from a single institution in China and the diagnostic value of the H3F3 K36M mutant antibody
Chondroblastoma: clinicopathological analyses of 307 cases from a single institution in China and the diagnostic value of the H3F3 K36M mutant antibody
IntroductionChondroblastoma (CB) is a rare cartilaginous neoplasm that accounts for fewer than 1% of all bone tumours, and...
Results of histopathological revisions of major salivary gland neoplasms in routine clinical practice
Results of histopathological revisions of major salivary gland neoplasms in routine clinical practice
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Macrophage polarisation in caesarean scar diverticulum
Macrophage polarisation in caesarean scar diverticulum
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Integration of rapid PCR testing as an adjunct to NGS in diagnostic pathology services within the UK: evidence from a case series of non-squamous, non-small cell lung cancer (NSCLC) patients with follow-up
Integration of rapid PCR testing as an adjunct to NGS in diagnostic pathology services within the UK: evidence from a case series of non-squamous, non-small cell lung cancer (NSCLC) patients with follow-up
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Comparison of T-cell immune responses to SARS-CoV-2 spike (S) and nucleocapsid (N) protein using an in-house flow-cytometric assay in laboratory employees with and without previously confirmed COVID-19 in South Africa: nationwide cross-sectional study
Comparison of T-cell immune responses to SARS-CoV-2 spike (S) and nucleocapsid (N) protein using an in-house flow-cytometric assay in laboratory employees with and without previously confirmed COVID-19 in South Africa: nationwide cross-sectional study
IntroductionThe novel coronavirus, SARS-CoV-2, emerged from China in December 2019, and has since spread globally to infec...
Journal of Clinical Pathology: 75 years and counting
Journal of Clinical Pathology: 75 years and counting
The policy of the Association of Clinical Pathology and of the Editorial Board of the new Journal is, therefore, to provid...
Hypertriglyceridaemia: a commentary
Hypertriglyceridaemia: a commentary
The diagnosis and specific management of hypertriglyceridaemia (HTG) is overshadowed and often ignored in favour of low-de...
Genomic landscape of colorectal carcinoma in sub-Saharan Africa
Genomic landscape of colorectal carcinoma in sub-Saharan Africa
Our understanding of the molecular classification of colorectal carcinoma (CRC) has evolved significantly over the past tw...
Defining invasion in breast cancer: the role of basement membrane
Defining invasion in breast cancer: the role of basement membrane
In the normal breast tissue, the duct lobular system comprises two cell types, epithelial and myoepithelial cells (MECs), ...
Thyroid autoantibodies
Thyroid autoantibodies
Thyroid-stimulating hormone (TSH) receptor antibody (TSH-R-Ab or TRAb) testing plays a pivotal role in arriving at the aet...
Clinicopathological significance of neutrophil-rich colorectal carcinoma
Clinicopathological significance of neutrophil-rich colorectal carcinoma
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Microsatellite instability evaluation: which test to use for endometrial cancer?
Microsatellite instability evaluation: which test to use for endometrial cancer?
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Reference standards for gene fusion molecular assays on cytological samples: an international validation study
Reference standards for gene fusion molecular assays on cytological samples: an international validation study
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High-risk human papillomavirus (HPV) detection in formalin-fixed paraffin-embedded cervical tissues: performances of Aptima HPV assay and Beckton Dickinson (BD) Onclarity assay
High-risk human papillomavirus (HPV) detection in formalin-fixed paraffin-embedded cervical tissues: performances of Aptima HPV assay and Beckton Dickinson (BD) Onclarity assay
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Potential pitfalls in multiplex PCR-based next-generation sequencing: a case-based report
Potential pitfalls in multiplex PCR-based next-generation sequencing: a case-based report
Amplicon-based next-generation sequencing (NGS) assays employ highly sensitive, rapid, and cost-effective methods to detec...
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