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Multi-resolution visual Mamba with multi-directional selective mechanism for retinal disease detection
Multi-resolution visual Mamba with multi-directional selective mechanism for retinal disease detection
IntroductionRetinal diseases significantly impact patients’ quality of life and increase social medical costs. Optical coh...
PD-1 inhibitor sintilimab treated patients with metastatic triple-negative breast cancer
PD-1 inhibitor sintilimab treated patients with metastatic triple-negative breast cancer
PurposeTriple-negative breast cancer (TNBC) is a highly challenging subtype due to a unique tumor microenvironment. Severa...
Development of a transformer-based deep learning algorithm for diabetic peripheral neuropathy classification using corneal confocal microscopy images
Development of a transformer-based deep learning algorithm for diabetic peripheral neuropathy classification using corneal confocal microscopy images
BackgroundDiabetic peripheral neuropathy (DPN) is common and can go unnoticed until it is firmly developed. This study aim...
Telocytes of the male reproductive system: dynamic tissue organizers
Telocytes of the male reproductive system: dynamic tissue organizers
Telocytes are CD34+ interstitial cells that have long cytoplasmic projections (called telopodes), and have been detected i...
Modification of Lhx2 activity for ex vivo amplification of human iPSC-derived hematopoietic stem/progenitor cells
Modification of Lhx2 activity for ex vivo amplification of human iPSC-derived hematopoietic stem/progenitor cells
Hematopoietic stem cells (HSCs) obtained from patient-derived human induced pluripotent stem cells (iPSCs) are a promising...
Tensions on the actin cytoskeleton and apical cell junctions in the C. elegans spermatheca are influenced by spermathecal anatomy, ovulation state and activation of myosin
Tensions on the actin cytoskeleton and apical cell junctions in the C. elegans spermatheca are influenced by spermathecal anatomy, ovulation state and activation of myosin
IntroductionCells generate mechanical forces mainly through myosin motor activity on the actin cytoskeleton. In C. elegans...
Corrigendum: A role for TRPC3 in mammalian testis development
Corrigendum: A role for TRPC3 in mammalian testis development
Corrigendum on: Ming, Z., Bagheri-Fam, S., Frost, E. R., Ryan, J. M., & Harley, V. R. (2024). A role for TRPC3 in ...
Micropropagation and reintroduction of the endemic Tripleurospermum ziganaense (Asteraceae) to its natural habitat
Micropropagation and reintroduction of the endemic Tripleurospermum ziganaense (Asteraceae) to its natural habitat
In this study, a rapid and efficient biotechnological method was developed for the critically endangered (CR) endemic spec...
Notch signaling regulates pulmonary fibrosis
Notch signaling regulates pulmonary fibrosis
Pulmonary fibrosis is a progressive interstitial lung disease associated with aging. The pathogenesis of pulmonary fibrosi...
Kaempferol enhances intestinal repair and inhibits the hyperproliferation of aging intestinal stem cells in Drosophila
Kaempferol enhances intestinal repair and inhibits the hyperproliferation of aging intestinal stem cells in Drosophila
IntroductionIntestinal stem cells (ISCs) are crucial for tissue repair and homeostasis because of their ability to self-re...
Adipose-derived cells surpass muscle-derived cells in primary cell isolation efficacy
Adipose-derived cells surpass muscle-derived cells in primary cell isolation efficacy
Anna T, Agnieszka BZ (2021) Adipose-derived stem cells secretome and its potential application in “stem cell-free therapy....
Pre-vascularized porous gelatin-coated β-tricalcium phosphate scaffolds for bone regeneration: an in vivo and in vitro investigation
Pre-vascularized porous gelatin-coated β-tricalcium phosphate scaffolds for bone regeneration: an in vivo and in vitro investigation
Vascularization is vital in bone tissue engineering, supporting development, remodeling, and regeneration. Lack of vascula...
Obesity may impair response to ovarian stimulation. A retrospective observational study on oocyte quality
Obesity may impair response to ovarian stimulation. A retrospective observational study on oocyte quality
BackgroundOvulatory dysfunction is more common in women with obesity. Body fat distribution is also crucial because anovul...
Targeting caspase-8/c-FLIPL heterodimer in complex II promotes DL-mediated cell death
Targeting caspase-8/c-FLIPL heterodimer in complex II promotes DL-mediated cell death
Death receptor (DR) networks are controlled by the assembly of the Death-Inducing Signaling Complex (DISC) and complex II....
The potential of diallyl trisulfide for cancer prevention and treatment, with mechanism insights
The potential of diallyl trisulfide for cancer prevention and treatment, with mechanism insights
Cancer has become an important public health problem worldwide, and there is currently a lack of effective treatment and p...
Differential abundance of microRNAs in seminal plasma extracellular vesicles (EVs) in Sahiwal cattle bull related to male fertility
Differential abundance of microRNAs in seminal plasma extracellular vesicles (EVs) in Sahiwal cattle bull related to male fertility
Sahiwal cattle, known for their high milk yield, are propagated through artificial insemination (AI) using male germplasm,...
The evolving landscape of ER-LD contact sites
The evolving landscape of ER-LD contact sites
Lipid droplets (LDs) are evolutionarily conserved dynamic organelles that play an important role in cellular physiology. G...
Editorial: Editors’ showcase 2023: insights in cell adhesion and migration
Cell migration involves cytoskeleton remodeling (Blanchoin et al. 2014), molecular motor activity (Vicente-Manzanares et a...
CAR-macrophage: Breaking new ground in cellular immunotherapy
CAR-macrophage: Breaking new ground in cellular immunotherapy
Chimeric Antigen Receptor (CAR) technology has revolutionized cellular immunotherapy, particularly with the success of CAR...
Editorial: Reviews and advances in cutting edge microscopy and imaging techniques in membrane trafficking and organellar dynamics
Membrane trafficking pathways play key roles in essential cellular processes including signal transduction, organelle tran...
Morphological, electrophysiological, and molecular alterations in foetal noncompacted cardiomyopathy induced by disruption of ROCK signalling
Morphological, electrophysiological, and molecular alterations in foetal noncompacted cardiomyopathy induced by disruption of ROCK signalling
Left ventricular noncompaction cardiomyopathy is associated with heart failure, arrhythmia, and sudden cardiac death. The ...
Mitochondrial non-energetic function and embryonic cardiac development
Mitochondrial non-energetic function and embryonic cardiac development
The initial contraction of the heart during the embryonic stage necessitates a substantial energy supply, predominantly de...
Editorial: Understanding the mesenchymal to epithelial transition: a much needed angle for epithelial mesenchymal plasticity
In this collection, we aimed to enhance our understanding of epithelial-mesenchymal plasticity (EMP), primarily through th...
EMF treatment delays mesenchymal stem cells senescence during long-term in vitro expansion by modulating autophagy
EMF treatment delays mesenchymal stem cells senescence during long-term in vitro expansion by modulating autophagy
IntroductionBone marrow mesenchymal stem cells (BMSCs) are widely used in tissue engineering and regenerative medicine as ...
Emerging roles of cancer-associated histone mutations in genomic instabilities
Emerging roles of cancer-associated histone mutations in genomic instabilities
Epigenetic mechanisms often fuel the quick evolution of cancer cells from normal cells. Mutations or aberrant expressions ...
IMPC-based screening revealed that ROBO1 can regulate osteoporosis by inhibiting osteogenic differentiation
IMPC-based screening revealed that ROBO1 can regulate osteoporosis by inhibiting osteogenic differentiation
IntroductionThe utilization of denosumab in treating osteoporosis highlights promising prospects for osteoporosis interven...
Asymmetric dimethylarginine induces maladaptive function of the blood-brain barrier
Asymmetric dimethylarginine induces maladaptive function of the blood-brain barrier
Growing body of evidence suggests that cardiovascular risk factor, asymmetric dimethylarginine (ADMA), can be implicated i...
Vitamin E supplementation prevents obesogenic diet-induced developmental abnormalities in SR-B1 deficient embryos
Vitamin E supplementation prevents obesogenic diet-induced developmental abnormalities in SR-B1 deficient embryos
IntroductionGenetic and environmental factors influence the risk of neural tube defects (NTD), congenital malformations ch...
Radiation-induced skin reactions: oxidative damage mechanism and antioxidant protection
Radiation-induced skin reactions: oxidative damage mechanism and antioxidant protection
According to official statistics, cancer remains the main reason of death and over 50% of patients with cancer receive rad...
Advances in different adult stem cell-derived exosomal non-coding RNAs for the treatment of neurological disorders: a narrative review
Advances in different adult stem cell-derived exosomal non-coding RNAs for the treatment of neurological disorders: a narrative review
Neurological disorders are being increasingly recognized as major causes of death and disability around the world. Neurolo...
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