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Zebrafish cobll1a regulates lipid homeostasis via the RA signaling pathway
Zebrafish cobll1a regulates lipid homeostasis via the RA signaling pathway
Background:The COBLL1 gene has been implicated in human central obesity, fasting insulin levels, type 2 diabetes, and bloo...
Cardiac fibroblasts in heart failure and regeneration
Cardiac fibroblasts in heart failure and regeneration
In heart disease patients, myocyte loss or malfunction invariably leads to fibrosis, involving the activation and accumula...
Editorial: Protein kinase inhibitors in neurodegeneration and cancer targeted therapies
Editorial: Protein kinase inhibitors in neurodegeneration and cancer targeted therapies
Protein kinases play roles in diverse cellular functions, with approximately 2% of the human genome dedicated to encoding ...
Editorial: Intervertebral disc degeneration: mechanisms and therapeutics
Editorial: Intervertebral disc degeneration: mechanisms and therapeutics
Low back pain (LBP) is a prevalent musculoskeletal disorder, affecting approximately 70% of individuals at some point in t...
Protein domains of low sequence complexity--dark matter of the proteome [Perspectives]
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemi...
WRN exonuclease imparts high fidelity on translesion synthesis by Y family DNA polymerases [Research Papers]
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemi...
NFATC2IP is a mediator of SUMO-dependent genome integrity [Research Papers]
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemi...
A germline point mutation in the MYC-FBW7 phosphodegron initiates hematopoietic malignancies [Research Papers]
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemi...
Corrigendium: Effects of RAS on the genesis of embryonal rhabdomyosarcoma [Errata]
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemi...
Overexpression of Fgf18 in cranial neural crest cells recapitulates Pierre Robin sequence in mice
Overexpression of Fgf18 in cranial neural crest cells recapitulates Pierre Robin sequence in mice
The pivotal role of FGF18 in the regulation of craniofacial and skeletal development has been well established. Previous s...
The bone marrow of mouse-rat chimeras contains progenitors of multiple pulmonary cell lineages
The bone marrow of mouse-rat chimeras contains progenitors of multiple pulmonary cell lineages
Radiation-induced lung injury (RILI) is a common complication of anti-cancer treatments for thoracic and hematologic malig...
TRIF-dependent signaling and its role in liver diseases
TRIF-dependent signaling and its role in liver diseases
TIR domain-containing adaptor inducing IFN-β (TRIF) is a crucial adaptor molecule downstream of toll-like receptors 3 (TLR...
Chimeric antigen receptor (CAR) modified T Cells in acute myeloid leukemia: limitations and expectations
Chimeric antigen receptor (CAR) modified T Cells in acute myeloid leukemia: limitations and expectations
Acute myeloid leukemia (AML) is an aggressive hematologic malignancy with a poor prognosis despite the advent of novel the...
The hidden messengers: cancer associated fibroblasts—derived exosomal miRNAs as key regulators of cancer malignancy
The hidden messengers: cancer associated fibroblasts—derived exosomal miRNAs as key regulators of cancer malignancy
Cancer-associated fibroblasts (CAFs), a class of stromal cells in the tumor microenvironment (TME), play a key role in con...
Forskolin induces FXR expression and enhances maturation of iPSC-derived hepatocyte-like cells
Forskolin induces FXR expression and enhances maturation of iPSC-derived hepatocyte-like cells
The generation of iPSC-derived hepatocyte-like cells (HLCs) is a powerful tool for studying liver diseases, their therapy ...
Cover image of cell death and resilience in health and disease
Cover image of cell death and resilience in health and disease
Cookies are used by this site. Cookie SettingsAll content on this site: Copyright © 2024 Elsevier B.V., its licensors, an...
JAML inhibits colorectal carcinogenesis by modulating the tumor immune microenvironment
JAML inhibits colorectal carcinogenesis by modulating the tumor immune microenvironment
It is necessary to explore new targets for the treatment of colon adenocarcinoma (COAD) according to the tumor microenviro...
Tumor endothelial cell-derived Sfrp1 supports the maintenance of cancer stem cells via Wnt signaling
Tumor endothelial cell-derived Sfrp1 supports the maintenance of cancer stem cells via Wnt signaling
Cancer stem cells (CSCs), which are critical targets for cancer therapy as they are involved in drug resistance to antican...
Identification and characterization of the Dmrt1B gene in the oriental river prawn, Macrobrachium nipponense
Identification and characterization of the Dmrt1B gene in the oriental river prawn, Macrobrachium nipponense
Dmrt (doublesex and mab-3 related transcription factor) is a protein family of transcription factors implicated in sexual ...
Editorial: Glioma: from genetic to cellular heterogeneity
Editorial: Glioma: from genetic to cellular heterogeneity
Gliomas are primary tumors of the central nervous system that affect individuals of all ages. Staggering 5-year 13 surviva...
Mesenchymal cell migration on one-dimensional micropatterns
Mesenchymal cell migration on one-dimensional micropatterns
Quantitative studies of mesenchymal cell motion are important to elucidate cytoskeleton function and mechanisms of cell mi...
NOX2 and NOX4 expression in monocytes and macrophages-extracellular vesicles in signalling and therapeutics
NOX2 and NOX4 expression in monocytes and macrophages-extracellular vesicles in signalling and therapeutics
Extracellular vesicles (EVs) are a type of cytoplasmic vesicles secreted by a variety of cells. EVs originating from cells...
Mitochondrial stress response and myogenic differentiation
Mitochondrial stress response and myogenic differentiation
Regeneration and repair are prerequisites for maintaining effective function of skeletal muscle under high energy demands,...
Editorial: New trends in cardiovascular development, evolution and disease
Editorial: New trends in cardiovascular development, evolution and disease
The heart represents the main conduit of the circulatory system, with the primary role of pumping the blood through the pu...
Mitochondrial control of lymphocyte homeostasis
Mitochondrial control of lymphocyte homeostasis
Volumes 161–162, September–October 2024, Pages 42-53Author links open overlay panel, , AbstractMitochondria play a multitu...