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Hyperactive KRAS/MAPK signaling disrupts normal lymphatic vessel architecture and function
Hyperactive KRAS/MAPK signaling disrupts normal lymphatic vessel architecture and function
Complex lymphatic anomalies (CLAs) are sporadically occurring diseases caused by the maldevelopment of lymphatic vessels. ...
Equine maternal aging affects the metabolomic profile of oocytes and follicular cells during different maturation time points
Equine maternal aging affects the metabolomic profile of oocytes and follicular cells during different maturation time points
Introduction: Oocyte quality and fertility decline with advanced maternal age. During maturation within the ovarian follic...
The odontoblastic differentiation of dental mesenchymal stem cells: molecular regulation mechanism and related genetic syndromes
The odontoblastic differentiation of dental mesenchymal stem cells: molecular regulation mechanism and related genetic syndromes
Dental mesenchymal stem cells (DMSCs) are multipotent progenitor cells that can differentiate into multiple lineages inclu...
Platelet factor 4 (PF4) induces cluster of differentiation 40 (CD40) expression in human aortic endothelial cells (HAECs) through the SIRT1/NF-κB/p65 signaling pathway
Platelet factor 4 (PF4) induces cluster of differentiation 40 (CD40) expression in human aortic endothelial cells (HAECs) through the SIRT1/NF-κB/p65 signaling pathway
PF4 is a pro-atherosclerotic molecule. Endothelial CD40, upon binding to its ligand CD40L, induces endothelial cell (EC) a...
Adult tissue-specific stem cell interaction: novel technologies and research advances
Adult tissue-specific stem cell interaction: novel technologies and research advances
Adult tissue-specific stem cells play a dominant role in tissue homeostasis and regeneration. Various in vivo markers of a...
Succinate metabolism: a promising therapeutic target for inflammation, ischemia/reperfusion injury and cancer
Succinate metabolism: a promising therapeutic target for inflammation, ischemia/reperfusion injury and cancer
Succinate serves as an essential circulating metabolite within the tricarboxylic acid (TCA) cycle and functions as a subst...
Characterization of fetal microchimeric immune cells in mouse maternal hearts during physiologic and pathologic pregnancies
Characterization of fetal microchimeric immune cells in mouse maternal hearts during physiologic and pathologic pregnancies
Introduction: During pregnancy, fetal cells can be incorporated into maternal tissues (fetal microchimerism), where they c...
In vitro inhibitory effect of zingerone on TNFα-stimulated fibroblast-like synoviocytes
In vitro inhibitory effect of zingerone on TNFα-stimulated fibroblast-like synoviocytes
Targeting Fibroblast-like synoviocytes (FLSs) is an attractive complementary approach for RA therapy. This study aimed to ...
Knockdown of ZnT4 Induced Apoptosis, Inhibited Proliferation and testosterone synthesis of TM3 cells
Knockdown of ZnT4 Induced Apoptosis, Inhibited Proliferation and testosterone synthesis of TM3 cells
Zinc deficiency has a huge impact on male reproduction. The zinc transporter (ZnT) family is involved in the maintenance o...
Phytochemical analysis and anti-UTI activity of essential oil from meta-topolin-induced micropropagated Artemisia vulgaris L.
Phytochemical analysis and anti-UTI activity of essential oil from meta-topolin-induced micropropagated Artemisia vulgaris L.
Artemisia vulgaris is a medicinally important essential oil–yielding plant belonging to Asteraceae, used as a tradit...
Development of an efficient micropropagation protocol for Nematanthus wettsteinii using leaf and shoot-tip explants
Development of an efficient micropropagation protocol for Nematanthus wettsteinii using leaf and shoot-tip explants
Nematanthus wettsteinii (Fritsch) H. E. Moore is one of the most popular ornamental species in China, and is known for its...
Putting a finger on histidine methylation [Outlook]
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemi...
Advancing therapeutics using antibody-induced dimerization of receptor tyrosine phosphatases [Outlook]
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemi...
Metabolic partitioning in the brain and its hijacking by glioblastoma [Reviews]
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemi...
Transcription factor networks link B-lymphocyte development and malignant transformation in leukemia [Reviews]
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemi...
Histidine N1-position-specific methyltransferase CARNMT1 targets C3H zinc finger proteins and modulates RNA metabolism [Research Papers]
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemi...
Uncovering a mammalian neural-specific poly(A) binding protein with unique properties [Research Papers]
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemi...
Manipulating PTPRD function with ectodomain antibodies [Research Papers]
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemi...
Emerging roles of proximal tubular endocytosis in renal fibrosis
Emerging roles of proximal tubular endocytosis in renal fibrosis
Endocytosis is a crucial component of many pathological conditions. The proximal tubules are responsible for reabsorbing t...
Transcriptome analyses reveal new insights on key determinants of perineural invasion in high-grade serous ovarian cancer
Transcriptome analyses reveal new insights on key determinants of perineural invasion in high-grade serous ovarian cancer
Perineural invasion (PNI) is a pathological feature of many cancers associated with poor outcomes, metastases, and recurre...
Interferon-β decreases LPS-induced neutrophil recruitment to cardiac fibroblasts
Interferon-β decreases LPS-induced neutrophil recruitment to cardiac fibroblasts
Introduction: Cardiac fibroblasts (CF) are crucial cells in damaged heart tissues, expressing TLR4, IFN-receptor and respo...
Immune-epigenetic crosstalk in haematological malignancies
Immune-epigenetic crosstalk in haematological malignancies
Haematological malignancies comprise a diverse set of lymphoid and myeloid neoplasms which can arise during any stage of h...
Effects of clinical medications on male fertility and prospects for stem cell therapy
Effects of clinical medications on male fertility and prospects for stem cell therapy
An increasing number of men require long-term drug therapy for various diseases. However, the effects of long-term drug th...
Ubiquitination of the protocadherin-γA3 variable cytoplasmic domain modulates cell-cell interaction
Ubiquitination of the protocadherin-γA3 variable cytoplasmic domain modulates cell-cell interaction
The family of ∼60 clustered protocadherins (Pcdhs) are cell adhesion molecules encoded by a genomic locus that regulates e...
Cell-specific secretory granule sorting mechanisms: the role of MAGEL2 and retromer in hypothalamic regulated secretion
Cell-specific secretory granule sorting mechanisms: the role of MAGEL2 and retromer in hypothalamic regulated secretion
Intracellular protein trafficking and sorting are extremely arduous in endocrine and neuroendocrine cells, which synthesiz...
Advances in the regulation of adipogenesis and lipid metabolism by exosomal ncRNAs and their role in related metabolic diseases
Advances in the regulation of adipogenesis and lipid metabolism by exosomal ncRNAs and their role in related metabolic diseases
Exosomes are membrane-bound extracellular vesicles released following the fusion of multivesicular bodies (MVBs) with the ...
The prolyl isomerase Pin1 stabilizes NeuroD during differentiation of mechanoreceptors
The prolyl isomerase Pin1 stabilizes NeuroD during differentiation of mechanoreceptors
The peptidyl prolyl cis-trans isomerase Pin1 plays vital roles in diverse cellular processes and pathological conditions. ...
Calpains, the proteases of two faces controlling the epithelial homeostasis in mammary gland
Calpains, the proteases of two faces controlling the epithelial homeostasis in mammary gland
Calpain-1 and calpain-2 are calcium-dependent Cys-proteases ubiquitously expressed in mammalian tissues with a processive,...
Self-assembled adipose-derived mesenchymal stem cells as an extracellular matrix component- and growth factor-enriched filler
Self-assembled adipose-derived mesenchymal stem cells as an extracellular matrix component- and growth factor-enriched filler
The clinical application of mesenchymal stem cells (MSCs) is attracting attention due to their excellent safety, convenien...
Regulation of phosphoinositide metabolism in Apicomplexan parasites
Regulation of phosphoinositide metabolism in Apicomplexan parasites
Phosphoinositides are a biologically essential class of phospholipids that contribute to organelle membrane identity, modu...
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