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New insights into the interplay between autophagy and cartilage degeneration in osteoarthritis
New insights into the interplay between autophagy and cartilage degeneration in osteoarthritis
Autophagy is an intracellular degradation system that maintains the stable state of cell energy metabolism. Some recent fi...
A review of current evidence about lncRNA MEG3: A tumor suppressor in multiple cancers
A review of current evidence about lncRNA MEG3: A tumor suppressor in multiple cancers
Long non-coding RNA (lncRNA) maternally expressed gene 3 (MEG3) is a lncRNA located at the DLK1-MEG3 site of human chromos...
Aptamer nucleotide analog drug conjugates in the targeting therapy of cancers
Aptamer nucleotide analog drug conjugates in the targeting therapy of cancers
Aptamers are short single-strand oligonucleotides that can form secondary and tertiary structures, fitting targets with hi...
Mechanochemical subcellular-element model of crawling cells
Mechanochemical subcellular-element model of crawling cells
Constructing physical models of living cells and tissues is an extremely challenging task because of the high complexities...
Resolving the gene expression maps of human first-trimester chorionic villi with spatial transcriptome
Resolving the gene expression maps of human first-trimester chorionic villi with spatial transcriptome
The placenta is important for fetal development in mammals, and spatial transcriptomic profiling of placenta helps to reso...
Perspectives on mitochondrial relevance in cardiac ischemia/reperfusion injury
Perspectives on mitochondrial relevance in cardiac ischemia/reperfusion injury
Cardiovascular disease is the most common cause of death worldwide and in particular, ischemic heart disease holds the mos...
Ciliary control of adipocyte progenitor cell fate regulates energy storage
Ciliary control of adipocyte progenitor cell fate regulates energy storage
The primary cilium is a cellular sensory organelle found in most cells in our body. This includes adipocyte progenitor cel...
Targets of histone H3 lysine 9 methyltransferases
Targets of histone H3 lysine 9 methyltransferases
Histone H3 lysine 9 di- and trimethylation are well-established marks of constitutively silenced heterochromatin domains f...
A region-dependent allele-biased expression of Dopa decarboxylase in mouse brain
A region-dependent allele-biased expression of Dopa decarboxylase in mouse brain
Genomic imprinting is an epigenetic event in which genes are expressed only from either the paternal or maternal allele. D...
Craniofacial and cardiac defects in chd7 zebrafish mutants mimic CHARGE syndrome
Craniofacial and cardiac defects in chd7 zebrafish mutants mimic CHARGE syndrome
Congenital heart defects occur in almost 80% of patients with CHARGE syndrome, a sporadically occurring disease causing cr...
JDB, Vol. 10, Pages 51: The Role of Primary Cilia-Associated Phosphoinositide Signaling in Development
JDB, Vol. 10, Pages 51: The Role of Primary Cilia-Associated Phosphoinositide Signaling in Development
Primary cilia are microtube-based organelles that extend from the cell surface and function as biochemical and mechanical ...
Cerebellar mutism syndrome: From pathophysiology to rehabilitation
Cerebellar mutism syndrome: From pathophysiology to rehabilitation
Cerebellar mutism syndrome (CMS) is a common complication following surgical resection of childhood tumors arising in the ...
Obesity and sudden cardiac death: Prevalence, pathogenesis, prevention and intervention
Obesity and sudden cardiac death: Prevalence, pathogenesis, prevention and intervention
Obesity and sudden cardiac death (SCD) share common risk factors. Obesity, in and of itself, can result in the development...
The role of retinal Müller cells in diabetic retinopathy and related therapeutic advances
The role of retinal Müller cells in diabetic retinopathy and related therapeutic advances
Diabetic retinopathy (DR) is a significant complication of diabetes. During the pathogenesis of retinal microangiopathy an...
1D micro-nanopatterned integrin ligand surfaces for directed cell movement
1D micro-nanopatterned integrin ligand surfaces for directed cell movement
Cell-extracellular matrix (ECM) adhesion mediated by integrins is a highly regulated process involved in many vital cellul...
Azoxystrobin exposure impairs meiotic maturation by disturbing spindle formation in mouse oocytes
Azoxystrobin exposure impairs meiotic maturation by disturbing spindle formation in mouse oocytes
Fungicides are a type of pesticide used to protect plants and crops from pathogenic fungi. Azoxystrobin (AZO), a natural m...