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ISG15–LFA1 interactions in latent HIV clearance: mechanistic implications in designing antiviral therapies
1 IntroductionViruses, including the human immunodeficiency virus (HIV)-1, often seem to find ways to overcome the host an...
A new therapy for microcystic lymphatic malformations: the combination of intralesional laser thermolysis and percutaneous sclerotherapy
IntroductionLymphatic malformations (LMs) are congenital lymphatic diseases often associated with somatic PIK3CA mutations...
Effects of advanced glycation end products on stem cell
1 IntroductionStem cells (SCs) possess unique self-renewal capacity and multidirectional differentiation potential. They c...
Liquid–liquid phase separation in hepatocellular carcinoma
IntroductionLLPS is a common form of density transition that many macromolecules can undergo, where a homogeneous solution...
Diverse perspectives on proteomic posttranslational modifications to address EGFR-TKI resistance in non-small cell lung cancer
1 IntroductionLung cancer is a malignant tumor with the highest morbidity and mortality of all cancers worldwide (Sung et ...
Maxing Yigan formula promotes cartilage regeneration by regulating chondrocyte autophagy in osteoarthritis
Maxing Yigan formula promotes cartilage regeneration by regulating chondrocyte autophagy in osteoarthritis
Maxing Yigan formula (MYF) is a traditional Chinese medicine (TCM) prescription used for the treatment of OA for decades i...
Zebrafish as a model system for studying reproductive diseases
1 IntroductionIn recent years, zebrafish (Danio rerio) have become a valuable model organism in diverse research fields, i...
The impact of ferroptosis and ferroptosis-related non-coding RNAs on breast cancer progression
1 IntroductionBreast cancer (BC) represents a significant global health threat to women (Makhoul et al., 2018). Recent can...
Efficacy of natural NF-κB inhibitors in the treatment of fibrosarcoma: an in vitro model study
1 IntroductionCancer is currently a significant public health issue, ranking among the leading causes of death worldwide. ...
PLK1 inhibition impairs erythroid differentiation
IntroductionPolo-like kinase 1 (PLK1), highly expressed in various primary tumor tissues including glioblastomas, thyroid ...
VRAC channel inhibition as a novel strategy for the treatment of ischemia-reperfusion injury
1 IntroductionIschemia-reperfusion injury (IRI) is an important clinical problem that occurs in multiple organs including ...
Efficacy and safety of pegylated liposomal doxorubicin and epirubicin as neoadjuvant chemotherapy for breast cancer
IntroductionBreast cancer is one of the most common types of malignancies in the world (Siegel et al., 2022). During the p...
Citri reticulate pericranium-derived extracellular vesicles exert antioxidant and anti-inflammatory properties and enhance the bioactivity of nobiletin by forming EVs-nob nanoparticles
1 IntroductionExtracellular vesicles (EVs) are a diverse set of nanoscale vesicles (varying in diame-ter from 30 to 1,000 ...
Retinal glia in myopia: current understanding and future directions
1 IntroductionThe prevalence of myopia continues to increase, such that it is expected to affect nearly half the global po...
Extracellular vesicles derived from dental follicle stem cells regulate tooth eruption by inhibiting osteoclast differentiation
1 IntroductionTooth eruption refers to the movement of a tooth from its developmental position through the bone and overly...
Recent advancement in the spatial immuno-oncology
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Transcriptomics as a predictor of biopharmaceutically favourable glycan profiles
IntroductionCell line development (CLD) is a pivotal step in biopharmaceutical manufacturing, focused on developing and id...
Ferroptosis and its role in osteoarthritis: mechanisms, biomarkers, and therapeutic perspectives
Ferroptosis and its role in osteoarthritis: mechanisms, biomarkers, and therapeutic perspectives
1 IntroductionOsteoarthritis (OA) is a highly prevalent and destructive degenerative joint disease, affecting approximatel...
Differentiation ability of hematopoietic stem cells and mesenchymal stem cells isolated from human peripheral blood
IntroductionHematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs) are the major stem cells of the bone marrow ...
Understanding the impact of ER stress on lung physiology
1 IntroductionThe process of aging is intricate, involving the gradual decline of tissues and organs throughout the body, ...
FTO in health and disease
FTO in health and disease
1 Discovering FTO and its functionIn 1999, Fto was identified as one of the several genes deleted in mice with the Ft (Fus...
Chlorogenic acid suppresses the expression of matrix metalloproteinase-7 and cell invasiveness to almost the same extent as isofraxidin in human colorectal cancer cells
Chlorogenic acid suppresses the expression of matrix metalloproteinase-7 and cell invasiveness to almost the same extent as isofraxidin in human colorectal cancer cells
The expression of matrix metalloproteinase (MMP)-7 is reported to be correlated with invasion and metastasis of colorectal...
Flow-cytometry reveals mitochondrial DNA accumulation in Saccharomyces cerevisiae cells during cell cycle arrest
IntroductionMitochondrial DNA (mtDNA) is a semi-autonomous genome present in almost all eukaryotic species (Roger et al., ...
Advancements in pseudouridine modifying enzyme and cancer
1 IntroductionPseudouridine (Ψ) is a post-transcriptional modification of RNA that plays a role in epigenetics. Epigenetic...
Collective sperm movement in mammalian reproductive tracts
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NCF-1 plays a pivotal role in the survival of adenocarcinoma cells of pancreatic and gastric origins
NCF-1 plays a pivotal role in the survival of adenocarcinoma cells of pancreatic and gastric origins
Reactive oxygen species (ROS) play a pivotal biological role in cells, with ROS function differing depending on cellular c...
Development and characterization of polyvinyl alcohol/gelatin/chitosan hydrogel for tissue engineering and wound healing applications using a fish cell line model
Development and characterization of polyvinyl alcohol/gelatin/chitosan hydrogel for tissue engineering and wound healing applications using a fish cell line model
Chitosan-based hydrogels have gained considerable attention in biomedical research due to their inherent biocompatibility,...
Retraction: Designing of SiO2 mesoporous nanoparticles loaded with mometasone furoate for potential nasal drug delivery: Ex vivo evaluation and determination of pro-inflammatory interferon and interleukin mRNA expression
Retraction: Designing of SiO2 Mesoporous Nanoparticles Loaded with Mometasone Furoate for Potential Nasal Drug Delivery: E...
Hydrogel systems for spatiotemporal controlled delivery of immunomodulators: engineering the tumor immune microenvironment for enhanced cancer immunotherapy
1 IntroductionIn recent years, the incidence and mortality of cancer have been rising all over the world. According to glo...
Corrigendum: Single nucleotide polymorphisms of porcine lncMGPF regulate meat production traits by affecting RNA stability
A Corrigendum onSingle Nucleotide Polymorphisms of Porcine lncMGPF Regulate Meat Production Traits by Affecting RNA Stabil...
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