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Hyperactive KRAS/MAPK signaling disrupts normal lymphatic vessel architecture and function
Hyperactive KRAS/MAPK signaling disrupts normal lymphatic vessel architecture and function
Complex lymphatic anomalies (CLAs) are sporadically occurring diseases caused by the maldevelopment of lymphatic vessels. ...
Adult tissue-specific stem cell interaction: novel technologies and research advances
Adult tissue-specific stem cell interaction: novel technologies and research advances
Adult tissue-specific stem cells play a dominant role in tissue homeostasis and regeneration. Various in vivo markers of a...
Succinate metabolism: a promising therapeutic target for inflammation, ischemia/reperfusion injury and cancer
Succinate metabolism: a promising therapeutic target for inflammation, ischemia/reperfusion injury and cancer
Succinate serves as an essential circulating metabolite within the tricarboxylic acid (TCA) cycle and functions as a subst...
In vitro inhibitory effect of zingerone on TNFα-stimulated fibroblast-like synoviocytes
In vitro inhibitory effect of zingerone on TNFα-stimulated fibroblast-like synoviocytes
Targeting Fibroblast-like synoviocytes (FLSs) is an attractive complementary approach for RA therapy. This study aimed to ...
Knockdown of ZnT4 Induced Apoptosis, Inhibited Proliferation and testosterone synthesis of TM3 cells
Knockdown of ZnT4 Induced Apoptosis, Inhibited Proliferation and testosterone synthesis of TM3 cells
Zinc deficiency has a huge impact on male reproduction. The zinc transporter (ZnT) family is involved in the maintenance o...
Putting a finger on histidine methylation [Outlook]
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemi...
Advancing therapeutics using antibody-induced dimerization of receptor tyrosine phosphatases [Outlook]
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemi...
Metabolic partitioning in the brain and its hijacking by glioblastoma [Reviews]
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemi...
Transcription factor networks link B-lymphocyte development and malignant transformation in leukemia [Reviews]
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemi...
Histidine N1-position-specific methyltransferase CARNMT1 targets C3H zinc finger proteins and modulates RNA metabolism [Research Papers]
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemi...
Uncovering a mammalian neural-specific poly(A) binding protein with unique properties [Research Papers]
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemi...
Manipulating PTPRD function with ectodomain antibodies [Research Papers]
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemi...
Emerging roles of proximal tubular endocytosis in renal fibrosis
Emerging roles of proximal tubular endocytosis in renal fibrosis
Endocytosis is a crucial component of many pathological conditions. The proximal tubules are responsible for reabsorbing t...
Interferon-β decreases LPS-induced neutrophil recruitment to cardiac fibroblasts
Interferon-β decreases LPS-induced neutrophil recruitment to cardiac fibroblasts
Introduction: Cardiac fibroblasts (CF) are crucial cells in damaged heart tissues, expressing TLR4, IFN-receptor and respo...
Immune-epigenetic crosstalk in haematological malignancies
Immune-epigenetic crosstalk in haematological malignancies
Haematological malignancies comprise a diverse set of lymphoid and myeloid neoplasms which can arise during any stage of h...
Effects of clinical medications on male fertility and prospects for stem cell therapy
Effects of clinical medications on male fertility and prospects for stem cell therapy
An increasing number of men require long-term drug therapy for various diseases. However, the effects of long-term drug th...
Ubiquitination of the protocadherin-γA3 variable cytoplasmic domain modulates cell-cell interaction
Ubiquitination of the protocadherin-γA3 variable cytoplasmic domain modulates cell-cell interaction
The family of ∼60 clustered protocadherins (Pcdhs) are cell adhesion molecules encoded by a genomic locus that regulates e...
The prolyl isomerase Pin1 stabilizes NeuroD during differentiation of mechanoreceptors
The prolyl isomerase Pin1 stabilizes NeuroD during differentiation of mechanoreceptors
The peptidyl prolyl cis-trans isomerase Pin1 plays vital roles in diverse cellular processes and pathological conditions. ...
Calpains, the proteases of two faces controlling the epithelial homeostasis in mammary gland
Calpains, the proteases of two faces controlling the epithelial homeostasis in mammary gland
Calpain-1 and calpain-2 are calcium-dependent Cys-proteases ubiquitously expressed in mammalian tissues with a processive,...
Regulation of phosphoinositide metabolism in Apicomplexan parasites
Regulation of phosphoinositide metabolism in Apicomplexan parasites
Phosphoinositides are a biologically essential class of phospholipids that contribute to organelle membrane identity, modu...