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Unveiling geniposide from Paederia foetida as a potential antihypertensive treatment: an integrated approach involving in vivo and computational methods
Unveiling geniposide from Paederia foetida as a potential antihypertensive treatment: an integrated approach involving in vivo and computational methods
Hypertension is one of the burning topics in today’s world. Natural product can open a new window in the treatment a...
Investigation of the antidiabetic and probiotic properties of lactic acid bacteria isolated from some ethnic fermented foods of Darjeeling District
Investigation of the antidiabetic and probiotic properties of lactic acid bacteria isolated from some ethnic fermented foods of Darjeeling District
Indigenous communities residing in the Darjeeling Himalayan region and its adjacent hilly areas have a deeply rooted cultu...
Evaluating the effect of artificial intelligence on pharmaceutical product and drug discovery in China
Evaluating the effect of artificial intelligence on pharmaceutical product and drug discovery in China
The pharmaceutical sector has recently witnessed a transformative improvement and shift toward artificial intelligence (AI...
nCoV-19 therapeutics using cucurbitacin I structural derivatives: an in silico approach
nCoV-19 therapeutics using cucurbitacin I structural derivatives: an in silico approach
Cucurbitacins are present in some common vegetables as secondary metabolites and are used by the plants against harmful mi...
Bioanalytical method development and validation for quantification of amivantamab in rat plasma by LC-MS/MS
Bioanalytical method development and validation for quantification of amivantamab in rat plasma by LC-MS/MS
Amivantamab is a monoclonal bispecific anti-EGFR-MET antibody used to treat non-small cell lung cancer. There were no publ...
Natural product-inspired strategies towards the discovery of novel bioactive molecules
Natural product-inspired strategies towards the discovery of novel bioactive molecules
The intricate molecular frameworks of natural products with biological activity towards human targets offer academic and i...
Development of docetaxel-loaded (Soluplus®–PF108) mixed micelles vacuum foam-dried product for improved stability and melanoma treatment by QbD approach
Development of docetaxel-loaded (Soluplus®–PF108) mixed micelles vacuum foam-dried product for improved stability and melanoma treatment by QbD approach
Docetaxel (DTX) finds extensive use in treating various cancers, but its limited solubility, side effects, and multi-drug ...
Influence of artificial intelligence in modern pharmaceutical formulation and drug development
Influence of artificial intelligence in modern pharmaceutical formulation and drug development
Artificial intelligence (AI) revolutionized the formulation and development of modern pharmaceuticals. With the help of AI...
Design, synthesis, and evaluation of anxiolytic activity of 2-(4-phenylpiperazin-1-yl)-1H-benz[d]imidazole and 2-(4-phenylpiperazin-1-methyl)-1H-benz[d]imidazole derivatives
Design, synthesis, and evaluation of anxiolytic activity of 2-(4-phenylpiperazin-1-yl)-1H-benz[d]imidazole and 2-(4-phenylpiperazin-1-methyl)-1H-benz[d]imidazole derivatives
In contemporary society, anxiety has become a widespread disorder leading to compromised well-being and heightened depress...
Antiproliferative effect of Saraca asoca methanol bark extract on triple negative breast cancer (TNBC)
Antiproliferative effect of Saraca asoca methanol bark extract on triple negative breast cancer (TNBC)
Saraca asoca (Asoka) is reported to possess phytoestrogenic components with anticancer properties. The phytoestrogens are ...
Size-dependent effects of niosomes on the penetration of methotrexate in skin layers
Size-dependent effects of niosomes on the penetration of methotrexate in skin layers
Niosomes hold promise as drug delivery systems for cancer treatment, with niosome size impacting stability, biodistributio...
Chemical composition and antifungal activity of Teucrium Leucocladum Boiss. essential oils growing in Egypt using two different techniques
Chemical composition and antifungal activity of Teucrium Leucocladum Boiss. essential oils growing in Egypt using two different techniques
Teucrium Leucocladum Boiss. (TL) (family Lamiaceae), indigenous to Sinai, Egypt, and Mediterranean region, is considered a...
Phytochemical screening, gas chromatograph/mass spectrometer (GCMS) analysis and molecular toxicological potential of Hunteria umbellata aqueous fruit extract against Staphylococcus aureus in accessory gene regulators (AGRs)
Phytochemical screening, gas chromatograph/mass spectrometer (GCMS) analysis and molecular toxicological potential of Hunteria umbellata aqueous fruit extract against Staphylococcus aureus in accessory gene regulators (AGRs)
Fruits of Hunteria umbellata (HU) have been utilized in folk medicine as potent against Staphylococcus aureus (SA) infecti...
Captopril pretreatment augments diabetogenic response to streptozotocin administration: experimental in vivo rat model
Captopril pretreatment augments diabetogenic response to streptozotocin administration: experimental in vivo rat model
Streptozotocin (STZ) is a glucose analogue commonly used for inducing diabetes in experimental animals. This study is inte...
A DoE-based development and characterization of Nadifloxacin-loaded transethosomal gel for the treatment of Acne vulgaris
A DoE-based development and characterization of Nadifloxacin-loaded transethosomal gel for the treatment of Acne vulgaris
The objective of this current research was to enhance the topical delivery of Nadifloxacin (NDFX) by incorporating it into...
Optimizing organically nano-fabricated Ni metal complexes for enhanced antioxidant and anticancer activity using response surface methodology
Optimizing organically nano-fabricated Ni metal complexes for enhanced antioxidant and anticancer activity using response surface methodology
Researchers, prompted by the toxicity and side effects associated with cisplatin, are exploring alternative approaches for...
Design of experiments and white analytical chemistry-driven green and sensitive spectrofluorimetric estimation of pregabalin in its pharmaceutical dosage forms and spiked human plasma
Design of experiments and white analytical chemistry-driven green and sensitive spectrofluorimetric estimation of pregabalin in its pharmaceutical dosage forms and spiked human plasma
Pregabalin (PGB) is a medication with anticonvulsant, analgesic and anxiolytic properties, employed in the treatment of ep...
Design, synthesis, 2D-QSAR, molecular dynamic simulation, and biological evaluation of topiramate–phenolic acid conjugates as PPARγ inhibitors
Design, synthesis, 2D-QSAR, molecular dynamic simulation, and biological evaluation of topiramate–phenolic acid conjugates as PPARγ inhibitors
Obesity is a precursor for many co-morbid diseases. One of the main triggering factors for obesity is the abnormal expansi...
Formulation and evaluation of nanobiotherapeutics of Terminalia arjuna through plant tissue culture for atherosclerosis
Formulation and evaluation of nanobiotherapeutics of Terminalia arjuna through plant tissue culture for atherosclerosis
The study seeks to investigate the therapeutic potential of Terminalia arjuna callus in addressing atherosclerosis. In ord...
Chemical characterization, safety profile and antileiomyoma effects of Tetrapleura tetraptera Taubert (Fabaceae) fruit ethanol extract in Sprague Dawley rats
Chemical characterization, safety profile and antileiomyoma effects of Tetrapleura tetraptera Taubert (Fabaceae) fruit ethanol extract in Sprague Dawley rats
Tetrapleura tetraptera Taubert (Fabaceae) fruits are employed by herbal practitioners in the management of uterine leiomyo...
Characterization of biochemical and optical properties of Nile tilapia (Oreochromis niloticus) corneal collagen
Characterization of biochemical and optical properties of Nile tilapia (Oreochromis niloticus) corneal collagen
Collagen extracted from fish body parts is a promising biological material. It has an important role in many pharmaceutica...
Genotype–phenotype correlation of fecal Streptococcus regulator (fsr) locus with gelatinase activity and biofilm formation intensity in clinical E. faecalis isolates
Genotype–phenotype correlation of fecal Streptococcus regulator (fsr) locus with gelatinase activity and biofilm formation intensity in clinical E. faecalis isolates
Enterococci, known for their disturbing involvement in nosocomial infections, possess a diverse set of virulence factors, ...
Dual drug-loaded cubosome nanoparticles for hepatocellular carcinoma: a design of experiment approach for optimization and in vitro evaluation
Dual drug-loaded cubosome nanoparticles for hepatocellular carcinoma: a design of experiment approach for optimization and in vitro evaluation
Liver cancer, a formidable and complex disease, poses a significant global health threat, stemming from various causes, in...
Assessing physicians’ knowledge, attitude, and practice on anticoagulant therapy in non-valvular atrial fibrillation: Syrian insights
Assessing physicians’ knowledge, attitude, and practice on anticoagulant therapy in non-valvular atrial fibrillation: Syrian insights
Atrial fibrillation (AF) is the most prevalent cardiac condition linked to increased mortality due to complications such a...
Enhanced therapeutic approach for diabetic foot ulcers: comparative study and characterisation of mupirocin-loaded nanosponge gel with marketed formulation for accelerating wound healing and in vivo evaluation
Enhanced therapeutic approach for diabetic foot ulcers: comparative study and characterisation of mupirocin-loaded nanosponge gel with marketed formulation for accelerating wound healing and in vivo evaluation
The current investigation aimed to develop, optimise, and assess a mupirocin-loaded nanosponge-based topical delivery syst...
Prognostic values and immune infiltration of KLF15, AQP7, AGPAT9 in glioma and glioblastoma
Prognostic values and immune infiltration of KLF15, AQP7, AGPAT9 in glioma and glioblastoma
The overall survival of patients with lower-grade gliomas and glioblastoma varies greatly. No reliable or existing procedu...
A comprehensive review comparing conventional versus traditional remedies in the treatment of endometriosis with futuristic insights
A comprehensive review comparing conventional versus traditional remedies in the treatment of endometriosis with futuristic insights
A common condition known as endometriosis typically takes place in females in their reproductive age and develops generall...
Evaluating the prediction power and accuracy of two smart response surface experimental designs after revisiting repaglinide floating tablets
Evaluating the prediction power and accuracy of two smart response surface experimental designs after revisiting repaglinide floating tablets
There is a soar in the figure of companies aiming to achieve efficiency in undergoing experimental processes. Therefore, i...
Optimization of simvastatin transdermal patch for hyperlipidemia treatment in rat model
Optimization of simvastatin transdermal patch for hyperlipidemia treatment in rat model
Biopharmaceutics Classification System says that simvastatin (SMV) is a Class II drug with low bioavailability (5%). This ...
Multi-epitope-based vaccine designing against Junín virus glycoprotein: immunoinformatics approach
Multi-epitope-based vaccine designing against Junín virus glycoprotein: immunoinformatics approach
The Junín virus (JUNV) is well known for causing argentine haemorrhagic fever (AHF), a severe endemic disease in farm...
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