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Carbapenem-resistant Acinetobacter baumannii infections among diabetic and non-diabetic patients and possible effective combination treatments
Carbapenem-resistant Acinetobacter baumannii infections among diabetic and non-diabetic patients and possible effective combination treatments
Carbapenems are one of the most noteworthy choices for treating multidrug-resistant Acinetobacter baumannii (A. baumannii)...
Adenocarcinoma of unknown primary with TP53 gene polymorphism: a rare case report with literature review
Adenocarcinoma of unknown primary with TP53 gene polymorphism: a rare case report with literature review
Cancer of unknown primary (CUP) is an orphan disease generally presented by undifferentiated and aggressive morphological ...
Cyclodextrin inclusion complex and amorphous solid dispersions as formulation approaches for enhancement of curcumin’s solubility and nasal epithelial membrane permeation
Cyclodextrin inclusion complex and amorphous solid dispersions as formulation approaches for enhancement of curcumin’s solubility and nasal epithelial membrane permeation
Curcumin is a compound that occurs in the rhizomes of the turmeric plant (Curcuma longa) and has shown potential for the t...
Expanding telmisartan’s therapeutic horizon: exploring its multifaceted mechanisms beyond cardiovascular disorders
Expanding telmisartan’s therapeutic horizon: exploring its multifaceted mechanisms beyond cardiovascular disorders
Telmisartan, a potent angiotensin II type-1 receptor blocker as well as partial PPAR–gamma agonist, has emerged as a...
Solid self-nanoemulsifying drug delivery systems of nimodipine: development and evaluation
Solid self-nanoemulsifying drug delivery systems of nimodipine: development and evaluation
This study aimed to formulate solid self-nanoemulsifying drug delivery systems (SNEDDS) for nimodipine (NIM). The selectio...
Analytical quality by design (AQbD) based optimization of RP-UPLC method for determination of nivolumab and relatlimab in bulk and pharmaceutical dosage forms
Analytical quality by design (AQbD) based optimization of RP-UPLC method for determination of nivolumab and relatlimab in bulk and pharmaceutical dosage forms
The Analytical Quality by Design (AQbD) methodology extends the application of Quality by Design (QbD) principles to the m...
Design, synthesis and evaluation of new methyl piperazine derivatives as anticancer agents
Design, synthesis and evaluation of new methyl piperazine derivatives as anticancer agents
To overcome the problem of side effects and toxicity, development of new anticancer agents is needed. Recently, piperidine...
Comparative study of UV spectroscopy, RP-HPLC and HPTLC methods for quantification of antiviral drug lamivudine in tablet formulation
Comparative study of UV spectroscopy, RP-HPLC and HPTLC methods for quantification of antiviral drug lamivudine in tablet formulation
In the current study, estimation of lamivudine (LMU) by UV spectroscopy, reverse-phase HPLC (RP-HPLC) and HPTLC methods in...
Hypoglycemic and hepatoprotective activity of Phellinus fastuosus on streptozotocin-induced diabetic rats and carbon tetrachloride-intoxicated rats, respectively
Hypoglycemic and hepatoprotective activity of Phellinus fastuosus on streptozotocin-induced diabetic rats and carbon tetrachloride-intoxicated rats, respectively
Phellinus fastuosus is a wood-eating medicinal fungus from Western Ghats of India. Therefore, we investigated hypoglycemic...
Quantum chemical modelling, molecular docking, synthesis and experimental anti-microbial activity of 1,4-diazepan linked piperidine derivative
Quantum chemical modelling, molecular docking, synthesis and experimental anti-microbial activity of 1,4-diazepan linked piperidine derivative
In this work, we represent synthesis, in silico analysis and biological activity of 1,4 diazepine linked piperidine deriva...
Diverse pharmacological actions of potential carbazole derivatives by influencing various pathways of molecular signaling
Diverse pharmacological actions of potential carbazole derivatives by influencing various pathways of molecular signaling
Carbazoles are an important class of heterocyclic aromatic compounds that contain nitrogen atom in the ring. They have a l...
Targeting small druggable compounds against 3RZE histamine H1 receptor as potential of anti-allergic drug applying molecular modeling approach
Targeting small druggable compounds against 3RZE histamine H1 receptor as potential of anti-allergic drug applying molecular modeling approach
Allergic disorders, prevalent global health concerns, afflict a substantial portion of the world’s population. These...
Green analytical chemistry-based spectrophotometric techniques for ternary component analysis of pain relievers
Green analytical chemistry-based spectrophotometric techniques for ternary component analysis of pain relievers
The management of pain presents a significant challenge in healthcare, particularly in cases where conventional therapies ...
A simple method for the determination of acyclovir concentrations in human plasma using high-performance liquid chromatography
A simple method for the determination of acyclovir concentrations in human plasma using high-performance liquid chromatography
Acyclovir is an anti-viral medication given to treat herpes simplex and herpes zoster infection. In some severe conditions...
Pomegranate extract-loaded surfactant-free zein nanoparticles as a promising green approach for hepatic cancer: optimization and in vitro cytotoxicity
Pomegranate extract-loaded surfactant-free zein nanoparticles as a promising green approach for hepatic cancer: optimization and in vitro cytotoxicity
Hepatic cancer endures a major health scourge as the consequence of a high incidence of > 1 million cases by ...
Exploration of different strategies of nanoencapsulation of bioactive compounds and their ensuing approaches
Exploration of different strategies of nanoencapsulation of bioactive compounds and their ensuing approaches
Nanotechnology has gained rapid popularity in many fields, such as food science. The labile bioactive is enclosed in a shi...
Exploring the antimicrobial activity of Origanum majorana L. against the highly virulent multidrug-resistant Acinetobacter baumannii AB5075: UPLC-HRMS profiling with in vitro and in silico studies
Exploring the antimicrobial activity of Origanum majorana L. against the highly virulent multidrug-resistant Acinetobacter baumannii AB5075: UPLC-HRMS profiling with in vitro and in silico studies
The infamous multidrug-resistant (MDR) bacterium Acinetobacter baumannii is becoming a nightmare in intensive care units a...
Phytochemical analysis and evaluation of antibacterial activity of various extracts from leaves, stems and roots of Thalictrum foliolosum
Phytochemical analysis and evaluation of antibacterial activity of various extracts from leaves, stems and roots of Thalictrum foliolosum
Thalictrum foliolosum, a member of the Ranunculus family, is recognized for its therapeutic potential in addressing gastri...
Evaluation of antioxidant activity in different Egyptian barley cultivars: an in vitro and in silico study
Evaluation of antioxidant activity in different Egyptian barley cultivars: an in vitro and in silico study
Cereals have historically played a crucial role in the human diet, serving as a significant natural source of energy and o...
Antibacterial activity of medicinal plants and their role in wound healing
Antibacterial activity of medicinal plants and their role in wound healing
The study of plant-based medications, or phytomedicine, involves a wide spectrum of biological activities. Due to the exis...
Prevention of paclitaxel-induced peripheral neuropathy: literature review of potential pharmacological interventions
Prevention of paclitaxel-induced peripheral neuropathy: literature review of potential pharmacological interventions
Paclitaxel administration is considered a keystone in the management of many types of cancers. However, paclitaxel chemoth...
Preclinical study on camellia sinensis extract-loaded nanophytosomes for enhancement of memory-boosting activity: optimization by central composite design
Preclinical study on camellia sinensis extract-loaded nanophytosomes for enhancement of memory-boosting activity: optimization by central composite design
The purpose of the present study was to enhance the memory-boosting activity of the standardized hydroalcoholic Camellia s...
A preliminary study on the impact of nutrient stress induction on drug cytotoxicity in glioblastoma cells and fibroblasts
A preliminary study on the impact of nutrient stress induction on drug cytotoxicity in glioblastoma cells and fibroblasts
Nutrient stress (NS), one of the hallmarks of the tumour microenvironment, can render cancer cells tolerant to cytotoxicit...
The role of LncRNAs and CircRNAs in osteoporosis: a focus on osteogenesis and osteoclastogenesis signaling pathways
The role of LncRNAs and CircRNAs in osteoporosis: a focus on osteogenesis and osteoclastogenesis signaling pathways
Osteoporosis is a crucial health concern interconnected with physical disabilities as well as financial burdens. It arises...
Hyaluronic acid: comprehensive review of a multifunctional biopolymer
Hyaluronic acid: comprehensive review of a multifunctional biopolymer
Hyaluronic acid (HA) has a broad range of cosmetic and therapeutic applications due to its unique physicochemical properti...
A new gas chromatographic method for quantification of Metformin hydrochloride and Vildagliptin in bulk and pharmaceutical dosage form: development and validation
A new gas chromatographic method for quantification of Metformin hydrochloride and Vildagliptin in bulk and pharmaceutical dosage form: development and validation
Metformin, an antidiabetic drug, assists in reducing the creation of glucose inside the liver. Vildagliptin, a DPP-4 inhib...
Unveiling geniposide from Paederia foetida as a potential antihypertensive treatment: an integrated approach involving in vivo and computational methods
Unveiling geniposide from Paederia foetida as a potential antihypertensive treatment: an integrated approach involving in vivo and computational methods
Hypertension is one of the burning topics in today’s world. Natural product can open a new window in the treatment a...
Investigation of the antidiabetic and probiotic properties of lactic acid bacteria isolated from some ethnic fermented foods of Darjeeling District
Investigation of the antidiabetic and probiotic properties of lactic acid bacteria isolated from some ethnic fermented foods of Darjeeling District
Indigenous communities residing in the Darjeeling Himalayan region and its adjacent hilly areas have a deeply rooted cultu...
Evaluating the effect of artificial intelligence on pharmaceutical product and drug discovery in China
Evaluating the effect of artificial intelligence on pharmaceutical product and drug discovery in China
The pharmaceutical sector has recently witnessed a transformative improvement and shift toward artificial intelligence (AI...
nCoV-19 therapeutics using cucurbitacin I structural derivatives: an in silico approach
nCoV-19 therapeutics using cucurbitacin I structural derivatives: an in silico approach
Cucurbitacins are present in some common vegetables as secondary metabolites and are used by the plants against harmful mi...
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