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Novel RP-HPLC method for simultaneous determination of dapagliflozin and teneligliptin in tablet formulation and identification of degradation products by LC-MS/MS
Novel RP-HPLC method for simultaneous determination of dapagliflozin and teneligliptin in tablet formulation and identification of degradation products by LC-MS/MS
Diabetes mellitus affects millions globally, necessitating effective management strategies. Glenmark Pharmaceutical Limite...
Engineered vildagliptin-loaded polymeric nanoparticles via microfluidic and spray drying for enhanced antidiabetic activity
Engineered vildagliptin-loaded polymeric nanoparticles via microfluidic and spray drying for enhanced antidiabetic activity
Vildagliptin (VLG), an antidiabetic agent, presents a potential solution to this widespread affliction. It exhibits notabl...
Molecular modeling and implications of Biochanin A on ghrelin and IGF-1/myostatin signaling in radiation triggered cachexia
Molecular modeling and implications of Biochanin A on ghrelin and IGF-1/myostatin signaling in radiation triggered cachexia
Cachexia, a loss of appetite and body weight as a result of systemic inflammation, considered one of the unavoidable side ...
Development and optimization of multivesicular gefitinib liposomal transdermal system employing lipoid S100 for breast cancer: pharmacokinetics, bioavailability, and skin irritation studies in Wistar rats
Development and optimization of multivesicular gefitinib liposomal transdermal system employing lipoid S100 for breast cancer: pharmacokinetics, bioavailability, and skin irritation studies in Wistar rats
Conventional therapies in cancer treatment face challenges including drug resistance, lack of specificity, and severe adve...
Metabolic syndrome severity z-score in non-diabetic non-obese Egyptian patients with chronic hepatitis c virus infection
Metabolic syndrome severity z-score in non-diabetic non-obese Egyptian patients with chronic hepatitis c virus infection
The risks of heart disease, resistance of insulin, and diabetes mellitus type II are increased in individuals diagnosed wi...
PEG600 induced krill oil-based nanoemulsion system: ternary phase behaviour and cytotoxicity assessment
PEG600 induced krill oil-based nanoemulsion system: ternary phase behaviour and cytotoxicity assessment
Endogenous substances of krill oil (KO) are lipophilic in nature and have clinical significance viz. DHA/EPA, phospholipid...
Studying the association between single nucleotide polymorphisms of metabolizing enzymes and the therapeutic serum levels of calcineurin inhibitors in Egyptian liver transplant patients
Studying the association between single nucleotide polymorphisms of metabolizing enzymes and the therapeutic serum levels of calcineurin inhibitors in Egyptian liver transplant patients
Many clinical variables might impact the pharmacokinetics of calcineurin inhibitors (CIs). Different alleles of cytochrome...
Drug repurposing in the treatment of chronic inflammatory diseases
Drug repurposing in the treatment of chronic inflammatory diseases
Chronic inflammation is an increasing global healthcare challenge with limited effective treatment options. Developing med...
The potential therapeutic role of Lisinopril in augmenting the striatal neuroplasticity via the striatal ACE2/Ang1-7/MAS receptor axis in 3-nitropropionic acid-induced Huntington’s disease in rats: shifting paradigms in Huntington’s disease treatment
The potential therapeutic role of Lisinopril in augmenting the striatal neuroplasticity via the striatal ACE2/Ang1-7/MAS receptor axis in 3-nitropropionic acid-induced Huntington’s disease in rats: shifting paradigms in Huntington’s disease treatment
The exact pathogenesis of Huntington’s disease (HD) remains unclear. However, mitochondrial dysfunction and oxidativ...
Design, synthesis, and anticancer evaluation of novel N-[5-(1,3,4,5-tetrahydroxycyclohexyl)-1,3,4-thiadiazole-2-yl] benzamide analogues through integrated computational and experimental approaches
Design, synthesis, and anticancer evaluation of novel N-[5-(1,3,4,5-tetrahydroxycyclohexyl)-1,3,4-thiadiazole-2-yl] benzamide analogues through integrated computational and experimental approaches
The main aim of the current study is to develop, synthesize, in silico, in vitro and in vivo potentials of N-[5-(1,3,4,5-t...
The battle against dental caries: defeating biofilm formed by bacterial isolates using vanillin and plant essential oils: in vitro and ex vivo approaches
The battle against dental caries: defeating biofilm formed by bacterial isolates using vanillin and plant essential oils: in vitro and ex vivo approaches
Infections caused by biofilm-forming bacteria have significantly linked to dental plaque and caries. The aim of this study...
Formulation and characterization of 5-fluorouracil and metformin biodegradable nanospheres for treating colon cancer
Formulation and characterization of 5-fluorouracil and metformin biodegradable nanospheres for treating colon cancer
Cancer and diabetes mellitus are quite common diseases found together worldwide. A considerable amount of evidence is avai...
The potential of xanthotoxin in the treatment of cognitive disorders: current insights and future perspectives
The potential of xanthotoxin in the treatment of cognitive disorders: current insights and future perspectives
The prevalence of cognitive diseases, including Alzheimer’s disease and other forms of dementia, poses a significant...
Cost-effectiveness analysis of denosumab versus alendronate for improving bone mineral density in renal transplant recipients: a comparative study
Cost-effectiveness analysis of denosumab versus alendronate for improving bone mineral density in renal transplant recipients: a comparative study
Denosumab and alendronate had a positive impact on bone mineral density (BMD) preservation after kidney transplantation. H...
Artesunate-driven autophagy: a shield against liver hypoxia/reoxygenation insult in rats via modulation of GLP1R, the chief metabolic kinase AMPK, mTOR, ULK1, P70S6K, cyclin D1, Akt, and GSK3β
Artesunate-driven autophagy: a shield against liver hypoxia/reoxygenation insult in rats via modulation of GLP1R, the chief metabolic kinase AMPK, mTOR, ULK1, P70S6K, cyclin D1, Akt, and GSK3β
Hepatic hypoxia/reoxygenation (H/R) insult is a critical issue in hepatic transplant and surgeries, profoundly influencing...
Simultaneous estimation of nebivolol hydrochloride and amlodipine besylate in human plasma employing an innovative HPLC chromatographic method
Simultaneous estimation of nebivolol hydrochloride and amlodipine besylate in human plasma employing an innovative HPLC chromatographic method
This study developed and validated a simple, robust, and cost-effective RP-HPLC bioanalytical method for the determination...
Effect of crude ethanolic seed extract from Mucuna pruriens on proliferation, apoptosis, and cell cycle arrest in gastric adenocarcinoma (AGS) cells
Effect of crude ethanolic seed extract from Mucuna pruriens on proliferation, apoptosis, and cell cycle arrest in gastric adenocarcinoma (AGS) cells
Gastric cancer is a prevalent form of malignancy among many common carcinoma cases globally. This study was designed to as...
α-Mangostin-phytosomes as a plausible nano-vesicular approach for enhancing cytotoxic activity on SKOV-3 ovarian cancer cells
α-Mangostin-phytosomes as a plausible nano-vesicular approach for enhancing cytotoxic activity on SKOV-3 ovarian cancer cells
α-Mangostin is a major xanthone in Garcinia mangostana L. (Clusiaceae) pericarps. It has promising anti-prol...
Evaluation of the effect of pentoxifylline on the prevention of paclitaxel‑induced peripheral neuropathy in breast cancer patients: a randomized controlled study
Evaluation of the effect of pentoxifylline on the prevention of paclitaxel‑induced peripheral neuropathy in breast cancer patients: a randomized controlled study
Paclitaxel-induced peripheral neuropathy (PIPN) is one of the most common and debilitating toxicity. Up till now, no treat...
Assessment of IV albumin and ringer lactate on the acute oral toxicity of acetylsalicylic acid in albino rats
Assessment of IV albumin and ringer lactate on the acute oral toxicity of acetylsalicylic acid in albino rats
Despite the frequent inclusion of fluid therapy in the treatment of many conditions, there are limited studies available t...
AQbD-novel strategy for analytical methods
AQbD-novel strategy for analytical methods
Analytical Quality by Design (AQbD) has emerged as a pivotal paradigm in the realm of analytical chemistry, revolutionizin...
Computational quest, synthesis and anticancer profiling of 3-methyl quinoxaline-2-one-based active hits against the tyrosine kinase
Computational quest, synthesis and anticancer profiling of 3-methyl quinoxaline-2-one-based active hits against the tyrosine kinase
Cancer is the predominant cause of mortality and a remarkable obstacle to elevating life anticipation in every nation on g...
Evaluation of treatment-related problems in hemodialysis patients in Egypt: a prospective observational study
Evaluation of treatment-related problems in hemodialysis patients in Egypt: a prospective observational study
Hemodialysis (HD) patients often have multiple comorbidities, leading to care from various prescribers and a complex medic...
Exhaustive computational studies on pyrimidine derivatives as GPR119 agonist for the development of compounds against NIDDM
Exhaustive computational studies on pyrimidine derivatives as GPR119 agonist for the development of compounds against NIDDM
Type-2 Diabetes (T2DM) is a long-term medical disorder characterized by Insulin deficiency and high blood glucose levels. ...
In vitro evaluation of the clinical utility of Apitolisib/Vorinostat combination in Apitolisib-resistant H1975 lung adenocarcinoma cells
In vitro evaluation of the clinical utility of Apitolisib/Vorinostat combination in Apitolisib-resistant H1975 lung adenocarcinoma cells
The PI3K signalling pathway regulates the metabolic activity of cells. Disruption by PI3K inhibitors causes an aerobic/ana...
Assessment of Piper longum L. (Piperaceae) leaves toxicity on the adults of Tribolium castaneum (Herbst, 1797) (Coleoptera: Tenebrionidae)
Assessment of Piper longum L. (Piperaceae) leaves toxicity on the adults of Tribolium castaneum (Herbst, 1797) (Coleoptera: Tenebrionidae)
Numerous insect pests attack stored grains causing both qualitative and quantitative losses. The most damaging pest that i...
Ameliorative activity of standardized Coccoloba uvifera leaves extract against streptozotocin-induced diabetic rats via activation of IRS-1/PI3K/AKT/GLUT2 pathway in liver
Ameliorative activity of standardized Coccoloba uvifera leaves extract against streptozotocin-induced diabetic rats via activation of IRS-1/PI3K/AKT/GLUT2 pathway in liver
Coccoloba uvifera L. (Family: Polygonaceae) known as sea grape is natively distributed in middle and south America. The aq...
In vitro and in vivo evaluation of crosslinked wound dressing loaded with combined rosuvastatin calcium and levofoxacin simultaneously determined by eco-friendly spectrophotometric method
In vitro and in vivo evaluation of crosslinked wound dressing loaded with combined rosuvastatin calcium and levofoxacin simultaneously determined by eco-friendly spectrophotometric method
Wound healing is a natural but complex process that can be delayed by infection. Rosuvastatin calcium (RVS) is an anti-hyp...
Hydroxytyrosol in cancer research: recent and historical insights on discoveries and mechanisms of action
Hydroxytyrosol in cancer research: recent and historical insights on discoveries and mechanisms of action
Cancer is a persistent global health challenge, demanding continuous exploration of innovative therapeutic strategies. Hyd...
Estimation of isoniazid by digital image colorimetry: an integration of green chemistry and smartphone technology
Estimation of isoniazid by digital image colorimetry: an integration of green chemistry and smartphone technology
This study proposes a simple digital image colorimetric method using a smartphone for the quantitative analysis of isoniaz...
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