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Regulation of VWF (Von Willebrand Factor) in Inflammatory Thrombosis
Increasing evidence indicates that inflammation promotes thrombosis via a VWF (von Willebrand factor)-mediated mechanism. ...
Angiopoietin-1 Is Required for Vortex Vein and Choriocapillaris Development in Mice
BACKGROUND: The choroidal vasculature, including the choriocapillaris and vortex veins, is essential for providing nutrien...
Lipoproteins and Calcific Aortic Valve Disease: Hardening Evidence?
Kevin D. O’Brien Correspondence to: Kevin D. O’Brien, MD, Division of Cardiology, Box 356422, University of Washington, 19...
Regulated Necrosis in Atherosclerosis
During atherosclerosis, lipid-rich plaques are formed in large- and medium-sized arteries, which can reduce blood flow to ...
PLCβ2 Promotes VEGF-Induced Vascular Permeability
PLCβ2 Promotes VEGF-Induced Vascular Permeability
Background: Regulation of vascular permeability is critical to maintaining tissue metabolic homeostasis. VEGF (vascular en...
Aspirin for the Primary Prevention of Cardiovascular Disease: Time for a Platelet-Guided Approach
Aspirin protects against atherothrombosis while increasing the risk of major bleeding. Although it is widely used to preve...
An Aspirin a Day…
James D. McFadyen Correspondence to: James D. McFadyen, Atherothrombosis and Vascular Biology Program, Baker Heart and Dia...
Variants in the GPR146 Gene Are Associated With a Favorable Cardiometabolic Risk Profile
BACKGROUND: In mice, GPR146 (G-protein–coupled receptor 146) deficiency reduces plasma lipids and protects against atheros...
Ceramide Metabolism in Cardiovascular Disease: A Network With High Therapeutic Potential
Growing evidence suggests that ceramides play an important role in the development of atherosclerotic and valvular heart d...
Molecular Magnetic Resonance Imaging for the Detection of Vulnerable Plaques
Recent advances in molecular resonance imaging of atherosclerosis enable to visualize atherosclerotic plaques in vivo usin...
Limited Effect of Y Chromosome Variation on Coronary Artery Disease and Mortality in UK Biobank—Brief Report
Limited Effect of Y Chromosome Variation on Coronary Artery Disease and Mortality in UK Biobank—Brief Report
Background: The effect of genetic variation in the male-specific region of the Y chromosome (MSY) on coronary artery disea...
Expression of CD70 Modulates Nitric Oxide and Redox Status in Endothelial Cells
Expression of CD70 Modulates Nitric Oxide and Redox Status in Endothelial Cells
Background: Endothelial dysfunction is a critical component in the pathogenesis of cardiovascular diseases and is closely ...
Expression of CD70 Modulates NO and Redox Status in Endothelial Cells
Background: Endothelial dysfunction is a critical component in the pathogenesis of cardiovascular diseases and is closely ...
Conductance Artery Wall Layers and Their Respective Roles in the Clearance Functions
Evolutionary organization of the arterial wall into layers occurred concomitantly with the emergence of a highly musculari...
ILRUNing to Atherosclerosis
"ILRUNing to Atherosclerosis." Arteriosclerosis, Thrombosis, and Vascular Biology, , pp. –FootnotesThe opinions expressed ...
Fostering New Scientific Networks in the COVID Era and Beyond
Over the last 2 years, the COVID-19 pandemic has stimulated the scientific community by starting a race to develop new vac...
PLC (Phospholipase C) β2 Promotes VEGF (Vascular Endothelial Growth Factor)–Induced Vascular Permeability
Background: Regulation of vascular permeability is critical to maintaining tissue metabolic homeostasis. VEGF (vascular en...
ILRUN Promotes Atherosclerosis Through Lipid-Dependent and Lipid-Independent Factors
BACKGROUND: Common genetic variation in close proximity to the ILRUN gene are significantly associated with coronary arter...
Limited Effect of Y Chromosome Variation on Coronary Artery Disease and Mortality in UK Biobank
Background: The effect of genetic variation in the male-specific region of the Y chromosome (MSY) on coronary artery disea...
Thromboinflammation: From Atherosclerosis to COVID-19
The activating interplay of thrombosis and inflammation (thromboinflammation) has been established as a major underlying p...
Microcalcification and Thoracic Aortopathy: A Window Into Disease Severity
BACKGROUND: Patients with thoracic aortopathy are at increased risk of catastrophic aortic dissection, carrying with it su...